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1. The First JWST Spectrum of a GRB Afterglow: No Bright Supernova in Observations of the Brightest GRB of all Time, GRB 221009A

Author: A. J. Levan, G. P. Lamb, B. Schneider, J. Hjorth, T. Zafar, A. de Ugarte Postigo, B. Sargent, S. E. Mullally, L. Izzo, P. D’Avanzo, E. Burns, J. F. Agüí Fernández, T. Barclay, M. G. Bernardini, K. Bhirombhakdi, M. Bremer, R. Brivio, S. Campana, A. A. Chrimes, V. D’Elia, M. Della Valle, M. De Pasquale, M. Ferro, W. Fong, A. S. Fruchter, J. P. U. Fynbo, N. Gaspari, B. P. Gompertz, D. H. Hartmann, C. L. Hedges, K. E. Heintz, K. Hotokezaka, P. Jakobsson, D. A. Kann, J. A. Kennea, T. Laskar, E. Le Floc’h, D. B. Malesani, A. Melandri, B. D. Metzger, S. R. Oates, E. Pian, S. Piranomonte, G. Pugliese, J. L. Racusin, J. C. Rastinejad, M. E. Ravasio, A. Rossi, A. Saccardi, R. Salvaterra, B. Sbarufatti, R. L. C. Starling, N. R. Tanvir, C. C. Thöne, A. J. van der Horst, S. D. Vergani, D. Watson, K. Wiersema, R. A. M. J. Wijers, and Dong Xu
Subjects: Gamma-ray bursts, Astrophysics, QB460-466
Abstract: We present James Webb Space Telescope (JWST) and Hubble Space Telescope (HST) observations of the afterglow of GRB 221009A, the brightest gamma-ray burst (GRB) ever observed. This includes the first mid-IR spectra of any GRB, obtained with JWST/Near Infrared Spectrograph (0.6–5.5 micron) and Mid-Infrared Instrument (5–12 micron), 12 days after the burst. Assuming that the intrinsic spectral slope is a single power law, with F _ν ∝ ν ^− ^β , we obtain β ≈ 0.35, modified by substantial dust extinction with A _V = 4.9. This suggests extinction above the notional Galactic value, possibly due to patchy extinction within the Milky Way or dust in the GRB host galaxy. It further implies that the X-ray and optical/IR regimes are not on the same segment of the synchrotron spectrum of the afterglow. If the cooling break lies between the X-ray and optical/IR, then the temporal decay rates would only match a post-jet-break model, with electron index p < 2, and with the jet expanding into a uniform ISM medium. The shape of the JWST spectrum is near-identical in the optical/near-IR to X-SHOOTER spectroscopy obtained at 0.5 days and to later time observations with HST. The lack of spectral evolution suggests that any accompanying supernova (SN) is either substantially fainter or bluer than SN 1998bw, the proto-type GRB-SN. Our HST observations also reveal a disk-like host galaxy, viewed close to edge-on, that further complicates the isolation of any SN component. The host galaxy appears rather typical among long-GRB hosts and suggests that the extreme properties of GRB 221009A are not directly tied to its galaxy-scale environment.
Published: 2023
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2. GRB 221009A: Discovery of an Exceptionally Rare Nearby and Energetic Gamma-Ray Burst

Author: Maia A. Williams, Jamie A. Kennea, S. Dichiara, Kohei Kobayashi, Wataru B. Iwakiri, Andrew P. Beardmore, P. A. Evans, Sebastian Heinz, Amy Lien, S. R. Oates, Hitoshi Negoro, S. Bradley Cenko, Douglas J. K. Buisson, Dieter H. Hartmann, Gaurava K. Jaisawal, N. P. M. Kuin, Stephen Lesage, Kim L. Page, Tyler Parsotan, Dheeraj R. Pasham, B. Sbarufatti, Michael H. Siegel, Satoshi Sugita, George Younes, Elena Ambrosi, Zaven Arzoumanian, M. G. Bernardini, S. Campana, Milvia Capalbi, Regina Caputo, Antonino D’Aì, P. D’Avanzo, V. D’Elia, Massimiliano De Pasquale, R. A. J. Eyles-Ferris, Elizabeth Ferrara, Keith C. Gendreau, Jeffrey D. Gropp, Nobuyuki Kawai, Noel Klingler, Sibasish Laha, A. Melandri, Tatehiro Mihara, Michael Moss, Paul O’Brien, Julian P. Osborne, David M. Palmer, Matteo Perri, Motoko Serino, E. Sonbas, Michael Stamatikos, Rhaana Starling, G. Tagliaferri, Aaron Tohuvavohu, Silvia Zane, and Houri Ziaeepour
Subjects: Gamma-ray bursts, Astrophysics, QB460-466
Abstract: We report the discovery of the unusually bright long-duration gamma-ray burst (GRB), GRB 221009A, as observed by the Neil Gehrels Swift Observatory (Swift), Monitor of All-sky X-ray Image, and Neutron Star Interior Composition Explorer Mission. This energetic GRB was located relatively nearby ( z = 0.151), allowing for sustained observations of the afterglow. The large X-ray luminosity and low Galactic latitude ( b = 4.°3) make GRB 221009A a powerful probe of dust in the Milky Way. Using echo tomography, we map the line-of-sight dust distribution and find evidence for significant column densities at large distances (≳10 kpc). We present analysis of the light curves and spectra at X-ray and UV–optical wavelengths, and find that the X-ray afterglow of GRB 221009A is more than an order of magnitude brighter at T _0 + 4.5 ks than that from any previous GRB observed by Swift. In its rest frame, GRB 221009A is at the high end of the afterglow luminosity distribution, but not uniquely so. In a simulation of randomly generated bursts, only 1 in 10 ^4 long GRBs were as energetic as GRB 221009A; such a large E _γ _,iso implies a narrow jet structure, but the afterglow light curve is inconsistent with simple top-hat jet models. Using the sample of Swift GRBs with redshifts, we estimate that GRBs as energetic and nearby as GRB 221009A occur at a rate of ≲1 per 1000 yr—making this a truly remarkable opportunity unlikely to be repeated in our lifetime.
Published: 2023
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3. Multimessenger Characterization of Markarian 501 during Historically Low X-Ray and γ-Ray Activity

Author: H. Abe, S. Abe, V. A. Acciari, I. Agudo, T. Aniello, S. Ansoldi, L. A. Antonelli, A. Arbet-Engels, C. Arcaro, M. Artero, K. Asano, D. Baack, A. Babić, A. Baquero, U. Barres de Almeida, J. A. Barrio, I. Batković, J. Baxter, J. Becerra González, W. Bednarek, E. Bernardini, M. Bernardos, A. Berti, J. Besenrieder, W. Bhattacharyya, C. Bigongiari, A. Biland, O. Blanch, G. Bonnoli, Ž. Bošnjak, I. Burelli, G. Busetto, R. Carosi, M. Carretero-Castrillo, A. J. Castro-Tirado, G. Ceribella, Y. Chai, A. Chilingarian, S. Cikota, E. Colombo, J. L. Contreras, J. Cortina, S. Covino, G. D’Amico, V. D’Elia, P. Da Vela, F. Dazzi, A. De Angelis, B. De Lotto, A. Del Popolo, M. Delfino, J. Delgado, C. Delgado Mendez, D. Depaoli, F. Di Pierro, L. Di Venere, E. Do Souto Espiñeira, D. Dominis Prester, A. Donini, D. Dorner, M. Doro, D. Elsaesser, G. Emery, J. Escudero, V. Fallah Ramazani, L. Fariña, A. Fattorini, L. Foffano, L. Font, C. Fruck, S. Fukami, Y. Fukazawa, R. J. García López, M. Garczarczyk, S. Gasparyan, M. Gaug, J. G. Giesbrecht Paiva, N. Giglietto, F. Giordano, P. Gliwny, N. Godinović, R. Grau, D. Green, J. G. Green, D. Hadasch, A. Hahn, T. Hassan, L. Heckmann, J. Herrera, D. Hrupec, M. Hütten, R. Imazawa, T. Inada, R. Iotov, K. Ishio, I. Jiménez Martínez, J. Jormanainen, D. Kerszberg, Y. Kobayashi, H. Kubo, J. Kushida, A. Lamastra, D. Lelas, F. Leone, E. Lindfors, L. Linhoff, S. Lombardi, F. Longo, R. López-Coto, M. López-Moya, A. López-Oramas, S. Loporchio, A. Lorini, E. Lyard, B. Machado de Oliveira Fraga, P. Majumdar, M. Makariev, G. Maneva, N. Mang, M. Manganaro, S. Mangano, K. Mannheim, M. Mariotti, M. Martínez, A. Mas-Aguilar, D. Mazin, S. Menchiari, S. Mender, S. Mićanović, D. Miceli, T. Miener, J. M. Miranda, R. Mirzoyan, E. Molina, H. A. Mondal, A. Moralejo, D. Morcuende, V. Moreno, T. Nakamori, C. Nanci, L. Nava, V. Neustroev, M. Nievas Rosillo, C. Nigro, K. Nilsson, K. Nishijima, T. Njoh Ekoume, K. Noda, S. Nozaki, Y. Ohtani, T. Oka, A. Okumura, J. Otero-Santos, S. Paiano, M. Palatiello, D. Paneque, R. Paoletti, J. M. Paredes, L. Pavletić, M. Persic, M. Pihet, G. Pirola, F. Podobnik, P. G. Prada Moroni, E. Prandini, G. Principe, C. Priyadarshi, W. Rhode, M. Ribó, J. Rico, C. Righi, A. Rugliancich, N. Sahakyan, T. Saito, S. Sakurai, K. Satalecka, F. G. Saturni, B. Schleicher, K. Schmidt, F. Schmuckermaier, J. L. Schubert, T. Schweizer, J. Sitarek, V. Sliusar, D. Sobczynska, A. Spolon, A. Stamerra, J. Strišković, D. Strom, M. Strzys, Y. Suda, T. Surić, H. Tajima, M. Takahashi, R. Takeishi, F. Tavecchio, P. Temnikov, K. Terauchi, T. Terzić, M. Teshima, L. Tosti, S. Truzzi, A. Tutone, S. Ubach, J. van Scherpenberg, M. Vazquez Acosta, S. Ventura, V. Verguilov, I. Viale, C. F. Vigorito, V. Vitale, I. Vovk, R. Walter, M. Will, C. Wunderlich, T. Yamamoto, D. Zarić, The MAGIC Collaboration, M. Cerruti, J. A. Acosta-Pulido, G. Apolonio, R. Bachev, M. Baloković, E. Benítez, I. Björklund, V. Bozhilov, L. F. Brown, A. Bugg, W. Carbonell, M. I. Carnerero, D. Carosati, C. Casadio, W. Chamani, W. P. Chen, R. A. Chigladze, G. Damljanovic, K. Epps, A. Erkenov, M. Feige, J. Finke, A. Fuentes, K. Gazeas, M. Giroletti, T. S. Grishina, A. C. Gupta, M. A. Gurwell,, E. Heidemann, D. Hiriart, W. J. Hou, T. Hovatta, S. Ibryamov, M. D. Joner, S. G. Jorstad, J. Kania, S. Kiehlmann, G. N. Kimeridze, E. N. Kopatskaya, M. Kopp, M. Korte, B. Kotas, S. Koyama, J. A. Kramer, L. Kunkel, S. O. Kurtanidze, O. M. Kurtanidze, A. Lähteenmäki, J. M. López, V. M. Larionov, E. G. Larionova, L. V. Larionova, C. Leto, C. Lorey, R. Mújica, G. M. Madejski, N. Marchili, A. P. Marscher, M. Minev, A. Modaressi, D. A. Morozova, T. Mufakharov, I. Myserlis, A. A. Nikiforova, M. G. Nikolashvili, E. Ovcharov, M. Perri, C. M. Raiteri, A. C. S. Readhead, A. Reimer, D. Reinhart, S. Righini, K. Rosenlehner, A. C. Sadun, S. S. Savchenko, A. Scherbantin, L. Schneider, K. Schoch, D. Seifert, E. Semkov, L. A. Sigua, C. Singh, P. Sola, Y. Sotnikova, M. Spencer, R. Steineke, M. Stojanovic, A. Strigachev, M. Tornikoski, E. Traianou, A. Tramacere, Yu. V. Troitskaya, I. S. Troitskiy, J. B. Trump, A. Tsai, A. Valcheva, A. A. Vasilyev, F. Verrecchia, M. Villata, O. Vince, K. Vrontaki, Z. R. Weaver, E. Zaharieva, and N. Zottmann
Subjects: Active galaxies, BL Lacertae objects, Markarian galaxies, Active galactic nuclei, Blazars, Astrophysics, QB460-466
Abstract: We study the broadband emission of Mrk 501 using multiwavelength observations from 2017 to 2020 performed with a multitude of instruments, involving, among others, MAGIC, Fermi's Large Area Telescope (LAT), NuSTAR, Swift, GASP-WEBT, and the Owens Valley Radio Observatory. Mrk 501 showed an extremely low broadband activity, which may help to unravel its baseline emission. Nonetheless, significant flux variations are detected at all wave bands, with the highest occurring at X-rays and very-high-energy (VHE) γ -rays. A significant correlation (>3 σ ) between X-rays and VHE γ -rays is measured, supporting leptonic scenarios to explain the variable parts of the emission, also during low activity. This is further supported when we extend our data from 2008 to 2020, and identify, for the first time, significant correlations between the Swift X-Ray Telescope and Fermi-LAT. We additionally find correlations between high-energy γ -rays and radio, with the radio lagging by more than 100 days, placing the γ -ray emission zone upstream of the radio-bright regions in the jet. Furthermore, Mrk 501 showed a historically low activity in X-rays and VHE γ -rays from mid-2017 to mid-2019 with a stable VHE flux (>0.2 TeV) of 5% the emission of the Crab Nebula. The broadband spectral energy distribution (SED) of this 2 yr long low state, the potential baseline emission of Mrk 501, can be characterized with one-zone leptonic models, and with (lepto)-hadronic models fulfilling neutrino flux constraints from IceCube. We explore the time evolution of the SED toward the low state, revealing that the stable baseline emission may be ascribed to a standing shock, and the variable emission to an additional expanding or traveling shock.
Published: 2023
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4. Multiwavelength study of the gravitationally lensed blazar QSO B0218+357 between 2016 and 2020

Author: V A Acciari, S Ansoldi, L A Antonelli, A Arbet Engels, M Artero, K Asano, D Baack, A Babić, A Baquero, U Barres de Almeida, J A Barrio, I Batković, J Becerra González, W Bednarek, L Bellizzi, E Bernardini, M Bernardos, A Berti, J Besenrieder, W Bhattacharyya, C Bigongiari, A Biland, O Blanch, G Bonnoli, Ž Bošnjak, G Busetto, R Carosi, G Ceribella, M Cerruti, Y Chai, A Chilingarian, S Cikota, S M Colak, E Colombo, J L Contreras, J Cortina, S Covino, G D’Amico, V D’Elia, P Da Vela, F Dazzi, A De Angelis, B De Lotto, M Delfino, J Delgado, C Delgado Mendez, D Depaoli, F Di Pierro, L Di Venere, E Do Souto Espiñeira, D Dominis Prester, A Donini, D Dorner, M Doro, D Elsaesser, V Fallah Ramazani, A Fattorini, G Ferrara, M V Fonseca, L Font, C Fruck, S Fukami, R J García López, M Garczarczyk, S Gasparyan, M Gaug, N Giglietto, F Giordano, P Gliwny, N Godinović, J G Green, D Green, D Hadasch, A Hahn, L Heckmann, J Herrera, J Hoang, D Hrupec, M Hütten, T Inada, S Inoue, K Ishio, Y Iwamura, I Jiménez, J Jormanainen, L Jouvin, Y Kajiwara, M Karjalainen, D Kerszberg, Y Kobayashi, H Kubo, J Kushida, A Lamastra, D Lelas, F Leone, E Lindfors, S Lombardi, F Longo, R López-Coto, M López-Moya, A López-Oramas, S Loporchio, B Machado de Oliveira Fraga, C Maggio, P Majumdar, M Makariev, M Mallamaci, G Maneva, M Manganaro, K Mannheim, L Maraschi, M Mariotti, M Martínez, D Mazin, S Menchiari, S Mender, S Mićanović, D Miceli, T Miener, M Minev, J M Miranda, R Mirzoyan, E Molina, A Moralejo, D Morcuende, V Moreno, E Moretti, V Neustroev, C Nigro, K Nilsson, K Nishijima, K Noda, S Nozaki, Y Ohtani, T Oka, J Otero-Santos, S Paiano, M Palatiello, D Paneque, R Paoletti, J M Paredes, L Pavletić, P Peñil, C Perennes, M Persic, P G Prada Moroni, E Prandini, C Priyadarshi, I Puljak, W Rhode, M Ribó, J Rico, C Righi, A Rugliancich, L Saha, N Sahakyan, T Saito, S Sakurai, K Satalecka, F G Saturni, B Schleicher, K Schmidt, T Schweizer, J Sitarek, I Šnidarić, D Sobczynska, A Spolon, A Stamerra, D Strom, M Strzys, Y Suda, T Surić, M Takahashi, F Tavecchio, P Temnikov, T Terzić, M Teshima, L Tosti, S Truzzi, A Tutone, S Ubach, J van Scherpenberg, G Vanzo, M Vazquez Acosta, S Ventura, V Verguilov, C F Vigorito, V Vitale, I Vovk, M Will, C Wunderlich, D Zarić, F de Palma, F D’Ammando, A Barnacka, D K Sahu, M Hodges, T Hovatta, S Kiehlmann, W Max-Moerbeck, A C S Readhead, R Reeves, T J Pearson, A Lähteenmäki, I Björklund, M Tornikoski, J Tammi, S Suutarinen, K Hada, and K Niinuma
Published: 2021
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5. Swift/UVOT follow-up of gravitational wave alerts in the O3 era

Author: S R Oates, F E Marshall, A A Breeveld, N P M Kuin, P J Brown, M De Pasquale, P A Evans, A J Fenney, C Gronwall, J A Kennea, N J Klingler, M J Page, M H Siegel, A Tohuvavohu, E Ambrosi, S D Barthelmy, A P Beardmore, M G Bernardini, S Campana, R Caputo, S B Cenko, G Cusumano, A D’Aì, P D’Avanzo, V D’Elia, P Giommi, D H Hartmann, H A Krimm, S Laha, D B Malesani, A Melandri, J A Nousek, P T O’Brien, J P Osborne, C Pagani, K L Page, D M Palmer, M Perri, J L Racusin, T Sakamoto, B Sbarufatti, J E Schlieder, G Tagliaferri, and E Troja
Published: 2021
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6. CD200R deletion promotes a neutrophil niche for Francisella tularensis and increases infectious burden and mortality

Author: J. Casulli, M. E. Fife, S. A. Houston, S. Rossi, J. Dow, E. D. Williamson, G. C Clark, T. Hussell, R. V. D’Elia, and M. A Travis
Subjects: Science
Abstract: The authors show that the CD200 receptor (CD200R) promotes effective clearance of pulmonary Francisella tularensis infection in knock out mice. This result is unexpected as CD200R is known to dampen pulmonary immune responses, and these data suggest that the beneficial effect against F. tularensis is due to depletion of a neutrophil niche for the bacterium.
Published: 2019
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7. Group 2 Innate Lymphoid Cells Are Detrimental to the Control of Infection withFrancisella tularensis

Author: Joshua Dow, Urszula M. Cytlak, Joshua Casulli, Craig P. McEntee, Catherine Smedley, Suzanne H. Hodge, Riccardo V. D’Elia, Matthew R. Hepworth, and Mark A. Travis
Subjects: Immunology, Immunology and Allergy
Abstract: Innate lymphoid cells (ILCs) are capable of rapid response to a wide variety of immune challenges, including various respiratory pathogens. Despite this, their role in the immune response against the lethal intracellular bacterium Francisella tularensis is not yet known. In this study, we demonstrate that infection of the airways with F. tularensis results in a significant reduction in lung type 2 ILCs (ILC2s) in mice. Conversely, the expansion of ILC2s via treatment with the cytokine IL-33, or by adoptive transfer of ILC2s, resulted in significantly enhanced bacterial burdens in the lung, liver, and spleen, suggesting that ILC2s may favor severe infection. Indeed, specific reduction of ILC2s in a transgenic mouse model results in a reduction in lung bacterial burden. Using an in vitro culture system, we show that IFN-γ from the live vaccine strain–infected lung reduces ILC2 numbers, suggesting that this cytokine in the lung environment is mechanistically important in reducing ILC2 numbers during infection. Finally, we show Ab-mediated blockade of IL-5, of which ILC2s are a major innate source, reduces bacterial burden postinfection, suggesting that IL-5 production by ILC2s may play a role in limiting protective immunity. Thus, overall, we highlight a negative role for ILC2s in the control of infection with F. tularensis. Our work therefore highlights the role of ILC2s in determining the severity of potentially fatal airway infections and raises the possibility of interventions targeting innate immunity during infection with F. tularensis to benefit the host.
Published: 2023

8. Missense NR2F1 variant in monozygotic twins affected with the Bosch–Boonstra–Schaaf optic atrophy syndrome

Author: Catia Mio, Federico Fogolari, Laura Pezzoli, Angela V. D’Elia, Maria Iascone, and Giuseppe Damante
Subjects: BBSOAS, monozygotic twins, NR2F1, whole exome sequencing, Genetics, QH426-470
Abstract: Abstract Background The Bosch‐Boonstra‐Schaaf optic atrophy syndrome (BBSOAS) is an autosomal‐dominant disorder (OMIM615722) mostly characterized by optic atrophy and/or hypoplasia, mild intellectual disability, hypotonia, seizures/infantile epilepsy. This disorder is caused by loss‐of‐function alterations of NR2F1 (i.e., either whole gene deletions or single nucleotide variants) and, to date, 40 patients have been identified with deletions or mutations in this gene. Here we describe two monozygotic twins harboring a de novo missense variant in the DNA‐binding domain of NR2F1 (c.313G>A, p.Gly105Ser), with well‐characterized features associated to BBSOAS. Methods Patients’ DNA was analyzed by exome sequencing identifying the missense variant c.313G>A in NR2F1 (NM_005654.4). Furthermore, molecular modeling was performed to evaluate putative differences in DNA binding between wild‐type and mutated NR2F1. Results The missense variant is predicted to be likely pathogenetic following the ACMG (American College of Medical Genetics and Genomics)/AMP (Association for Molecular Pathology) guidelines. Indeed, dynamic simulation experiments highlighted that the Gly105Ser substitution let the formation of a hydrogen bond between the S105 side chain and R142 and a base (G5) of the DNA sequence, allowing us to hypothesize that the G105 residue might be evolutionary conserved due to the absence of a side chain, besides glycine conformational features. Therefore, the G105S variation seems to cause a stiffening and a possible deformation in the protein‐DNA complex due to the interaction of residues R142‐S105 and G5 on the DNA, compared to the wild‐type. Conclusion In summary, we described two monozygotic twins harboring a novel Gly105Ser mutation in NR2F1 DNA binding domain, displaying the classical phenotype of BBSOAS‐affected patients. Our computational data suggest a dominant negative effect of this newly characterized missense variant. To date, this is the first genetic report analyzing in silico structural consequences of NR2F1 Gly105Ser substitution.
Published: 2020
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9. The fraction of ionizing radiation from massive stars that escapes to the intergalactic medium

Author: N R Tanvir, J P U Fynbo, A de Ugarte Postigo, J Japelj, K Wiersema, D Malesani, D A Perley, A J Levan, J Selsing, S B Cenko, D A Kann, B Milvang-Jensen, E Berger, Z Cano, R Chornock, S Covino, A Cucchiara, V D’Elia, A Gargiulo, P Goldoni, A Gomboc, K E Heintz, J Hjorth, L Izzo, P Jakobsson, L Kaper, T Krühler, T Laskar, M Myers, S Piranomonte, G Pugliese, A Rossi, R Sánchez-Ramírez, S Schulze, M Sparre, E R Stanway, G Tagliaferri, C C Thöne, S Vergani, P M Vreeswijk, R A M J Wijers, D Watson, and D Xu
Published: 2018
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10. Swift Multiwavelength Follow-up of LVC S200224ca and the Implications for Binary Black Hole Mergers

Author: N J Klinger, A Lien, S R Oates, J A Kennea, P A Evans, A Tohuvavohu, B Zhang, K L Page, S B Cenko, S D Barthelmy, A P Beardmore, M G Bernardini, A A Breeveld, P J Brown, D N Burrows, S Campana, G Cusumano, A D'Ai, P D'Avanzo, V D'Elia, M de Pasquale, S W K Emery, J Garcia, P Giommi, C Gronwall, D H Hartmann, H A Krimm, N P M Kuin, D B Malesani, F E Marshall, A Melandri, J A Nousek, P T O'Brien, J P Osborne, D M Palmer, M J Page, M Perri, J L Racusin, T Sakamoto, B Sbarufatti, J E Schlieder, M H Siegel, G Tagliaferri, and E Troja
Subjects: Astronomy
Abstract: On 2020 February 24, during their third observing run (“O3”), the Laser Interferometer Gravitational-wave Observatory and Virgo Collaboration detected S200224ca: a candidate gravitational wave (GW) event produced by a binary black hole (BBH) merger. This event was one of the best-localized compact binary coalescences detected in O3 (with 50%/90% error regions of 13/72 deg2), and so the Neil Gehrels Swift Observatory performed rapid near-UV/X-ray follow-up observations. Swift-XRT and UVOT covered approximately 79.2% and 62.4% (respectively) of the GW error region, making S200224ca the BBH event most thoroughly followed-up in near-UV (u-band) and X-ray to date. No likely EM counterparts to the GW event were found by the Swift BAT, XRT, or UVOT, nor by other observatories. Here, we report on the results of our searches for an EM counterpart, both in the BAT data near the time of the merger, and in follow-up UVOT/XRT observations. We also discuss the upper limits we can place on EM radiation from S200224ca, as well as the implications these limits have on the physics of BBH mergers. Namely, we place a shallow upper limit on the dimensionless BH charge, qˆ < 1.4 x 10-4, and an upper limit on the isotropic-equivalent energy of a blast wave E<4.1×1051 erg (assuming typical GRB parameters).
Published: 2021
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11. Multiwavelength Variability and Correlation Studies of Mrk 421 During Historically Low X-ray and Y-ray Activity in 2015–2016

Author: Janeth Valverde Quispe, V. A. Acciari, S. Ansoldi, L. A. Antonelli, K. Asano, A. Babic, B. Banerjee, A. Baquero, U.BarresdeAlmeida, J. A. Barrio, J. Becerra Gonzalez, W. Bednarek, L. Bellizzi, E. Bernardini, M. Bernardos, A. Berti, J. Besenrieder, W. Bhattacharyya, C. Bigongiari, O. Blanch, G. Bonnoli, Z. Bosnjak, G. Busetto, R. Carosi, G. Ceribella, M. Cerruti, Y. Chai, A. Chilingarian, S. Cikota, S. M. Colak, E. Colombo, J. L. Contreras, J. Cortina, S. Covino, G. D’Amico, V. D’Elia, P. Da Vela, F. Dazzi, A. De Angelis, B. De Lotto, M. Delfino, J. Delgado, C. Delgado Mendez, D. Depaoli, T. Di Girolamo, F. Di Pierro, L. Di Venere, E. Do Souto Espineira, D. Dominis Prester, A. Donini, M. Doro, V. Fallah Ramazani, A. Fattorini, G. Ferrara, L. Foffano, M. V. Fonseca, L. Font, C. Fruck, S. Fukami, R. J. Garcıa Lopez, M. Garczarczyk, S. Gasparyan, M. Gaug, N. Giglietto, F. Giordano, P. Gliwny, N. Godinovic, J. G. Green, D. Green, D. Hadasch, A. Hahn, L. Heckmann, J. Herrera, J. Hoang, D. Hrupec, M. Hutten, T. Inada, S. Inoue, K. Ishio, Y. Iwamura, J. Jormanainen, L. Jouvin, Y. Kajiwara, M. Karjalainen, D. Kerszberg, Y. Kobayashi, H. Kubo, J. Kushida, A. Lamastra, D. Lelas, F. Leone, E. Lindfors, S. Lombardi, F. Longo, M. Lopez, R. Lopez-Coto, A. Lopez-Oramas, S. Loporchio, B. Machado de Oliveira Fraga, C. Maggio, P. Majumdar, M. Makariev, M. Mallamaci, G. Maneva, M. Manganaro, L. Maraschi, M. Mariotti, M. Martınez, D. Mazin, S. Mender, S. Micanovic, D. Miceli, T. Miener, M. Minev, J. M. Miranda, R. Mirzoyan, E. Molina, A. Moralejo, D. Morcuende, V. Moreno, E. Moretti, P. Munar-Adrover, V. Neustroev, C. Nigro, K. Nilsson, D. Ninci, K. Nishijima, K. Noda, S. Nozaki, Y. Ohtani, T. Oka, J. Otero-Santos, M. Palatiello, D. Paneque, R. Paoletti, J. M. Paredes, L. Pavletic, P. P enil, C. Perennes, M. Persic, P. G . Prada Moroni, E. Prandini, C. Priyadarshi, I. Puljak, W. Rhode, M. Ribo, J. Rico, C. Righi, A. Rugliancich, L. Saha, N. Sahakyan, T. Saito, S. Sakurai, K. Satalecka, B. Schleicher, K. Schmidt, T. Schweizer, J. Sitarek, I. Snidaric, D. Sobczynska, A. Spolon, A. Stamerra, D. Strom, M. Strzys, Y. Suda, T. Suric, M. Takahashi, F. Tavecchio, P. Temnikov, T. Terzic, M. Teshima, N. Torres-Alba, L. Tosti, S. Truzzi, J. van Scherpenberg, G. Vanzo, M. Vazquez Acosta, S. Ventura, V. Verguilov, C. F. Vigorito, V. Vitale, I. Vovk, M. Will, D. Zaric, A. Arbet-Engels, D. Baack, M. Balbo, M. Beck, N. Biederbeck, A. Biland, T. Bretz, K. Bruegge, J. Buss, D. Dorner, D. Elsaesser, D. Hildebrand, R. Iotov, M. Klinger, K. Mannheim, D. Neise, A. Neronov, M. Noethe, A. Paravac, V. Sliusar, F. Theissen, R. Walter, J. Valverde, D. Horan, M. Giroletti, M. Perri, F. Verrecchia, C. Leto, A. C. Sadun, J. W. Moody, M. Joner, A. P. Marscher, S. G. Jorstad, A. Lahteenmaki, M. Tornikoski, V. Ramakrishnan, E. Jarvela, R. J. C. Vera, S. Righini, and A.Y.Lien
Subjects: Astronomy
Abstract: We report a characterization of the multiband flux variability and correlations of the nearby (z=0.031) blazar Markarian 421(Mrk 421) using data from Mets ̈ahovi, Swift, Fermi-LAT, MAGIC, FACT, and other collaborations and instruments from 2014November till 2016 June. Mrk 421 did not show any prominent flaring activity, but exhibited periods of historically low activity above 1 TeV (F>1TeV<1.7×10−12ph cm−2s−1) and in the 2–10 keV (X-ray) band (F2−10 keV<3.6×10−11erg cm−2s−1),during which the Swift-BAT data suggest an additional spectral component beyond the regular synchrotron emission. The highest flux variability occurs in X-rays and very high-energy (E>0.1 TeV)γ-rays, which, despite the low activity, show a significant positive correlation with no time lag. The HRkeV and HRTeV show the harder-when-brighter trend observed in many blazars, but the trend flattens at the highest fluxes, which suggests a change in the processes dominating the blazar variability. Enlarging our dataset with data from years 2007 to 2014, we measured a positive correlation between the optical and the GeV emission over a range of about 60 d centred at time lag zero, and a positive correlation between the optical/GeV and the radio emission over a range of about 60 d centred at a time lag of 43+9−6d. This observation is consistent with the radio-bright zone being located about 0.2 parsec downstream from the optical/GeV emission regions of the jet. The flux distributions are better described with a lognormal function in most of the energy bands probed, indicating that the variability in Mrk 421 is likely produced by a multiplicative process.
Published: 2020
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12. Assessment of CD200R Activation in Combination with Doxycycline in a Model of Melioidosis

Author: R. E. Thom, E. D. Williamson, J. Casulli, W. A. Butcher, G. Burgess, T. R. Laws, P. Huxley, R. Ashfield, M. A. Travis, and R. V. D’Elia
Subjects: Microbiology (medical), Infectious Diseases, General Immunology and Microbiology, Ecology, Physiology, Genetics, Cell Biology
Abstract: Traditional treatments for infectious disease have focused on the use of antimicrobial compounds (e.g. antibiotics) that target the infecting organism. However, timely diagnosis and administration of antibiotics remain crucial to ensure efficacy of these treatments especially for the highly virulent biothreat organisms.
Published: 2023

13. Fermi and Swift Observations of GRB 190114C: Tracing the Evolution of High-energy Emission from Prompt to Afterglow

Author: M. Ajello, M. Arimoto, M. Axelsson, L. Baldini, G. Barbiellini, D. Bastieri, R. Bellazzini, A. Berretta, E. Bissaldi, R. D. Blandford, R. Bonino, E. Bottacini, J. Bregeon, P. Bruel, R. Buehler, E. Burns, S. Buson, R. A. Cameron, R. Caputo, P. A. Caraveo, E. Cavazzuti, S. Chen, G. Chiaro, S. Ciprini, J. Cohen-Tanugi, D. Costantin, S. Cutini, F.D’Ammando, M. DeKlotz, P. de la Torre Luque, F. de Palma, A. Desai, N. Di Lalla, L. Di Venere, F. Fana Dirirsa, S. J. Fegan, A. Franckowiak, Y. Fukazawa, S. Funk, P. Fusco, F. Gargano, D. Gasparrini, N. Giglietto, R. Gill, F. Giordano, M. Giroletti, J. Granot, D. Green, I. A. Grenier, M.-H. Grondin, S. Guiriec, E. Hays, D. Horan, G. Jóhannesson, D. Kocevski, M. Kovac’evic’, M. Kuss, S. Larsson, L. Latronico, M. Lemoine-Goumard, J.Li, I. Liodakis, F. Longo, F. Loparco, M. N. Lovellette, P. Lubrano, S. Maldera, D. Malyshev, A. Manfreda, G. Martí-Devesa, M. N. Mazziotta, J. E. McEnery, I. Mereu, M. Meyer, P. F. Michelson, W. Mitthumsiri, T. Mizuno, M. E. Monzani, E. Moretti, A. Morselli, I. V. Moskalenko, M. Negro, E. Nuss, N. Omodei, M. Orienti, E. Orlando, M. Palatiello, V. S. Paliya, D. Paneque, Z. Pei, M. Persic, M. Pesce-Rollins, V. Petrosian, F. Piron, H. Poon, T. A. Porter, G. Principe, J. L. Racusin, S. Rainò, R. Rando, B. Rani, M. Razzano, S. Razzaque, A. Reimer, O. Reimer, F. Ryde, P. M. Saz Parkinson, D. Serini, C. Sgrò, E. J. Siskind, G. Spandre, P. Spinelli, H. Tajima, K. Takagi, M. N. Takahashi, D. Tak, J. B. Thayer, D. J. Thompson, D. F. Torres, E. Troja, J. Valverde, B. Van Klaveren, K. Wood, M. Yassine, G. Zaharijas, B. Mailyan, P. N. Bhat, M. S. Briggs, W. Cleveland, M. Giles, A. Goldstein, M. Hui, Christian Malacaria, R. Preece, O. J. Roberts, P. Veres, C. Wilson-Hodge, A. von Kienlin, S. B. Cenko, P. O’Brien, A. P. Beardmore, A. Lien, J. P. Osborne, A. Tohuvavohu, V. D’Elia, A.D’Aì, M. Perri, J. Gropp, N. Klingler, M. Capalbi, G. Tagliaferri, M. Stamatikos, and M. De Pasquale
Subjects: Astronomy
Abstract: We report on the observations of gamma-ray burst (GRB) 190114C by the Fermi Gamma-ray Space Telescope and the Neil Gehrels Swift Observatory. The prompt gamma-ray emission was detected by the Fermi GRB Monitor (GBM), the Fermi Large Area Telescope (LAT), and the Swift Burst Alert Telescope (BAT) and the long-lived afterglow emission was subsequently observed by the GBM, LAT, Swift X-ray Telescope (XRT), and Swift UV Optical Telescope. The early-time observations reveal multiple emission components that evolve independently, with a delayed power-law component that exhibits significant spectral attenuation above 40 MeV in the first few seconds of the burst. This power-law component transitions to a harder spectrum that is consistent with the afterglow emission observed by the XRT at later times. This afterglow component is clearly identifiable in the GBM and BAT light curves as a slowly fading emission component on which the rest of the prompt emission is superimposed. As a result, we are able to observe the transition from internal-shock- to external-shock-dominated emission. We find that the temporal and spectral evolution of the broadband afterglow emission can be well modeled as synchrotron emission from a forward shock propagating into a wind-like circumstellar environment. We estimate the initial bulk Lorentz factor using the observed high-energy spectral cutoff. Considering the onset of the afterglow component, we constrain the deceleration radius at which this forward shock begins to radiate in order to estimate the maximum synchrotron energy as a function of time. We find that even in the LAT energy range, there exist high-energy photons that are in tension with the theoretical maximum energy that can be achieved through synchrotron emission from a shock. These violations of the maximum synchrotron energy are further compounded by the detection of very high-energy (VHE) emission above 300 GeV by MAGIC concurrent with our observations. We conclude that the observations of VHE photons from GRB 190114C necessitates either an additional emission mechanism at very high energies that is hidden in the synchrotron component in the LAT energy range, an acceleration mechanism that imparts energy to the particles at a rate that is faster than the electron synchrotron energy-loss rate, or revisions of the fundamental assumptions used in estimating the maximum photon energy attainable through the synchrotron process.
Published: 2020
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14. Corrigendum to 'Accurate mapping of Brazil nut trees (Bertholletia excelsa) in Amazonian forests using WorldView-3 satellite images and convolutional neural networks'.

Author: Matheus Pinheiro Ferreira, Rodolfo Georjute Lotte, Francisco V. D'Elia, Christos Stamatopoulos, Do-Hyung Kim, Maria Beatriz Nogueira Ribeiro, and Adam R. Benjamin
Published: 2021
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15. Accurate mapping of Brazil nut trees (Bertholletia excelsa) in Amazonian forests using WorldView-3 satellite images and convolutional neural networks.

Author: Matheus Pinheiro Ferreira, Rodolfo Georjute Lotte, Francisco V. D'Elia, Christos Stamatopoulos, Do-Hyung Kim, and Adam R. Benjamin
Published: 2021
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16. Observation of inverse Compton emission from a long γ-ray burst

Author: P. Veres, P. N. Bhat, M. S. Briggs, W. H. Cleveland, R. Hamburg, C. M. Hui, B. Mailyan, R. D. Preece, O. J. Roberts, A. von Kienlin, C. A. Wilson-Hodge, D. Kocevski, M. Arimoto, D. Tak, K. Asano, M. Axelsson, G. Barbiellini, E. Bissaldi, F.Fana Dirirsa, R. Gill, J. Granot, J. McEnery, N. Omodei, S. Razzaque, F. Piron, J. L. Racusin, D. J. Thompson, S. Campana, M. G. Bernardini, N. P. M. Kuin, M. H. Siegel, S. B. Cenko, P. O’Brien, M. Capalbi, A. Daì, M. De Pasquale, J. Gropp, N. Klingler, J. P. Osborne, M. Perri, R. L. C. Starling, G. Tagliaferri, A. Tohuvavohu, A. Ursi, M.Tavani, M. Cardillo, C. Casentini, G. Piano, Y. Evangelista, F. Verrecchia, C. Pittori, F. Lucarelli, A. Bulgarelli, N. Parmiggiani, G. E. Anderson, J. P. Anderson, G. Bernardi, J. Bolmer, M. D. Caballero-García, I. M. Carrasco, A. Castellón, N. Castro Segura, A. J. Castro-Tirado, S. V. Cherukuri, A. M. Cockeram, P. D’Avanzo, A. Di Dato, R. Diretse, R. P. Fender, E. Fernández-García, J. P. U. Fynbo, A. S.Fruchter, J. Greiner, M. Gromadzki, K. E. Heintz, I. Heywood, A. J. van der Horst, Y.-D. Hu, C. Inserra, L. Izzo, V. Jaiswal, P. Jakobsson, J. Japelj, E. Kankare, D. A.Kann, C. Kouveliotou, S. Klose, A. J. Levan, X. Y. Li, S. Lotti, K. Maguire, D. B. Malesani, I. Manulis, M. Marongiu, S. Martin, A. Melandri, M. J.Michałowski, J. C. A. Miller-Jones, K. Misra, A. Moin, K. P. Mooley, S. Nasri, M. Nicholl, A. Noschese, G. Novara, S. B. Pandey, E. Peretti, C. J. Pérez del Pulgar, M. A. Pérez-Torres, D. A. Perley, L. Piro, F. Ragosta, L. Resmi, R. Ricci, A. Rossi, R. Sánchez-Ramírez, J. Selsing, S. Schulze, S. J. Smartt, I. A. Smith, V. V. Sokolov, J. Stevens, N. R. Tanvir, C. C. Thöne, A. Tiengo, E. Tremou, E. Troja, A. de Ugarte Postigo, A. F. Valeev, S. D. Vergani, M. Wieringa, P. A. Woudt, D. Xu, O. Yaron, D. R. Young, V. A. Acciari, S. Ansoldi, L. A. Antonelli, A. Arbet Engels, D. Baack, A. Babić, B. Banerjee, U. Barres de Almeida, J. A. Barrio, J. Becerra González, W. Bednarek, L. Bellizzi, E. Bernardini, A. Berti, J. Besenrieder, W. Bhattacharyya, C. Bigongiari, A. Biland, O. Blanch, G. Bonnoli, Ž. Bošnjak, G. Busetto, R. Carosi, G. Ceribella, Y. Chai, A. Chilingaryan, S. Cikota, S. M. Colak, U. Colin, E. Colombo, J. L. Contreras, J. Cortina, S. Covino, V. D’Elia, P. Da Vela, F. Dazzi, A. De Angelis, B. De Lotto, M. Delfino, J. Delgado, D. Depaoli, F. Di Pierro, L. Di Venere, E. Do Souto Espiñeira, D. Dominis Prester, A. Donini, D. Dorner, M. Doro, D. Elsaesser, V. Fallah Ramazani, A. Fattorini, G. Ferrara, D. Fidalgo, L. Foffano, M. V. Fonseca, L. Font, C. Fruck, S. Fukami, R. J. García López, M. Garczarczyk, S.Gasparyan, M. Gaug, N. Giglietto, F. Giordano, N. Godinović, D. Green, D. Guberman, D. Hadasch, A. Hahn, J. Herrera, J. Hoang, D. Hrupec, M. Hütten, T. Inada, S. Inoue, K. Ishio, Y. Iwamura, L. Jouvin, D. Kerszberg, H. Kubo, J. Kushida, A. Lamastra, D. Lelas, F. Leone, E. Lindfors, S. Lombardi, F. Longo, M. López, R. López-Coto, A. López-Oramas, S. Loporchio, B. Machado de Oliveira Fraga, C. Maggio, P. Majumdar, M. Makariev, M. Mallamaci, G. Maneva, M. Manganaro, K. Mannheim, L. Maraschi, M. Mariotti, M. Martínez, D. Mazin, S. Mićanović, D. Miceli, M. Minev, J. M. Miranda, R. Mirzoyan, E. Molina, A. Moralejo, D. Morcuende, V. Moreno, E. Moretti, P. Munar-Adrover, V. Neustroev, C. Nigro, K. Nilsson, D. Ninci, K. Nishijima, K. Noda, L. Nogués, S. Nozaki, S. Paiano, M. Palatiello, D. Paneque, R. Paoletti, J. M. Paredes, P. Peñil, M. Peresano, M. Persic, P. G. Prada Moroni, E. Prandini, I. Puljak, W. Rhode, M. Ribó, J. Rico, C. Righi, A. Rugliancich, L. Saha, N. Sahakyan, T. Saito, S. Sakurai, K. Satalecka, K. Schmidt, T. Schweizer, J. Sitarek, I. Šnidarić, D. Sobczynska, A. Somero, A. Stamerra, D. Strom, M. Strzys, Y. Suda, T. Surić, M. Takahashi, F. Tavecchio, P. Temnikov, T. Terzić, M. Teshima, N. Torres-Albà, L. Tosti, V. Vagelli, J. van Scherpenberg, G. Vanzo, M. Vazquez Acosta, C. F. Vigorito, V. Vitale, I. Vovk, M. Will, D. Zarić, and L. Nava
Subjects: Space Sciences (General)
Abstract: Long-duration γ-ray bursts (GRBs) originate from ultra-relativistic jets launched from the collapsing cores of dying massive stars. They are characterized by an initial phase of bright and highly variable radiation in the kiloelectronvolt-to-megaelectronvolt band, which is probably produced within the jet and lasts from milliseconds to minutes, known as the prompt emission. Subsequently, the interaction of the jet with the surrounding medium generates shock waves that are responsible for the afterglow emission, which lasts from days to months and occurs over a broad energy range from the radio to the gigaelectronvolt bands. The afterglow emission is generally well explained as synchrotron radiation emitted by electrons accelerated by the external shock. Recently, intense long-lasting emission between 0.2 and 1 teraelectronvolts was observed from GRB 190114C. Here we report multifrequency observations of GRB 190114C, and study the evolution in time of the GRB emission across 17 orders of magnitude in energy, from 5 × 10^(−6) to 10^(12) electronvolts. We find that the broadband spectral energy distribution is double-peaked, with the teraelectronvolt emission constituting a distinct spectral component with power comparable to the synchrotron component. This component is associated with the afterglow and is satisfactorily explained by inverse Compton up-scattering of synchrotron photons by high-energy electrons. We find that the conditions required to account for the observed teraelectronvolt component are typical for GRBs, supporting the possibility that inverse Compton emission is commonly produced in GRBs.
Published: 2019
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17. Swift-XRT Follow-up of Gravitational-wave Triggers in the Second Advanced LIGO/Virgo Observing Run

Author: N. J. Klingler, J. A. Kennea, P. A. Evans, A. Tohuvavohu, S. B. Cenko, S. D. Barthelmy, A. P. Beardmore, A. A. Breeveld, P. J. Brown, D. N. Burrows, S. Campana, G. Cusumano, A. D'Aì, P. D’Avanzo, V. D’Elia, M. de Pasquale, S. W. K. Emery, J. Garcia, P. Giommi, C. Gronwall, D. H. Hartmann, H. A. Krimm, N. P. M. Kuin, A. Lien, D. B. Malesani, F. E. Marshall, A. Melandri, J. A. Nousek, S. R. Oates, P. T. O’Brien, J. P. Osborne, K. L. Page, D. M. Palmer, M. Perri, J. L. Racusin, M. H. Siegel, T. Sakamoto, B. Sbarufatti, Gianpiero Tagliaferri, and E. Troja
Subjects: Astrophysics, Astronomy
Abstract: The Neil Gehrels Swift Observatory carried out prompt searches for gravitational-wave (GW) events detected by the LIGO/Virgo Collaboration (LVC) during the second observing run ("O2"). Swift performed extensive tiling of eight LVC triggers, two of which had very low false-alarm rates (GW170814 and the epochal GW170817), indicating a high confidence of being astrophysical in origin; the latter was the first GW event to have an electromagnetic counterpart detected. In this paper we describe the follow-up performed during O2 and the results of our searches. No GW electromagnetic counterparts were detected; this result is expected, as GW170817 remained the only astrophysical event containing at least one neutron star after LVC's later retraction of some events. A number of X-ray sources were detected, with the majority of identified sources being active galactic nuclei. We discuss the detection rate of transient X-ray sources and their implications in the O2 tiling searches. Finally, we describe the lessons learned during O2 and how these are being used to improve the Swift follow-up of GW events. In particular, we simulate a population of gamma-ray burst afterglows to evaluate our source ranking system's ability to differentiate them from unrelated and uncataloged X-ray sources. We find that ≈60%–70% of afterglows whose jets are oriented toward Earth will be given high rank (i.e., "interesting" designation) by the completion of our second follow-up phase (assuming that their location in the sky was observed), but that this fraction can be increased to nearly 100% by performing a third follow-up observation of sources exhibiting fading behavior.
Published: 2019
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18. Immune profiling of the progression of a BALB/c mouse aerosol infection by Burkholderia pseudomallei and the therapeutic implications of targeting HMGB1

Author: Thomas R. Laws, Graeme C. Clark, and Riccardo V. D’Elia
Subjects: Mice, Burkholderia pseudomallei, HMGB1, Cytokines, Infection, Infectious and parasitic diseases, RC109-216
Abstract: Introduction: The role of damage-associated molecular pattern HMGB1 signalling in a murine BALB/c model of severe respiratory melioidosis (Burkholderia pseudomallei infection) was explored in this study. Methods: Time course experiments were performed. Results: It was established that HMGB1 was released in concert with increasing weight of organs and increasing concentration of liver enzymes in the blood a short time after cytokine release. Differences in the cytokine response between organs were observed, where the lungs contained higher concentrations of chemokines and interleukin 17, while the spleen produced more interferon-gamma, which is essential in the host defence against B. pseudomallei. This is evidence as to why the disease is seemingly more severe in the respiratory form. The effect of depleting HMGB1 using an antibody was also evaluated. It was found that this treatment significantly reduced bacterial load in the liver, spleen, and, to a greater degree, in the lungs. Cytokine quantification indicated that this reduction in bacterial load is likely due to the treatment reducing the release of a variety of pro-inflammatory cytokines. Conclusion: It is concluded that anti-HMGB1 treatment would be effective alongside other therapeutics, where it would reduce the characteristic over-inflammation associated with late stage infection.
Published: 2015
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19. Spectropolarimetry and photometry of the early afterglow of the gamma-ray burst GRB 191221B

Author: D A H Buckley, S Bagnulo, R J Britto, J Mao, D A Kann, J Cooper, V Lipunov, D M Hewitt, S Razzaque, N P M Kuin, I M Monageng, S Covino, P Jakobsson, A J van der Horst, K Wiersema, M Böttcher, S Campana, V D’Elia, E S Gorbovskoy, I Gorbunov, D N Groenewald, D H Hartmann, V G Kornilov, C G Mundell, R Podesta, J K Thomas, N Tyurina, D Vlasenko, B van Soelen, D Xu, National Research Foundation (South Africa), Russian Foundation for Basic Research, European Commission, Ministerio de Economía y Competitividad (España), and Ministerio de Ciencia e Innovación (España)
Subjects: High Energy Astrophysical Phenomena (astro-ph.HE), Space and Planetary Science, Magnetic fields, Polarimetry, Jets, FOS: Physical sciences, Astronomy and Astrophysics, Gamma-ray bursts, Astrophysics - High Energy Astrophysical Phenomena, High energy astrophysics, Shocks, QC, QB
Abstract: Full list of authors: Buckley, D. A. H.; Bagnulo, S.; Britto, R. J.; Mao, J.; Kann, D. A.; Cooper, J.; Lipunov, V.; Hewitt, D. M.; Razzaque, S.; Kuin, N. P. M.; Monageng, I. M.; Covino, S.; Jakobsson, P.; van der Horst, A. J.; Wiersema, K.; Böttcher, M.; Campana, S.; D'Elia, V.; Gorbovskoy, E. S.; Gorbunov, I.; Groenewald, D. N.; Hartmann, D. H.; Kornilov, V. G.; Mundell, C. G.; Podesta, R.; Thomas, J. K.; Tyurina, N.; Vlasenko, D.; van Soelen, B.; Xu, D., We report on results of spectropolarimetry of the afterglow of the long gamma-ray burst GRB 191221B, obtained with SALT/RSS and VLT/FORS2, as well as photometry from two telescopes in the MASTER Global Robotic Network, at the MASTER-SAAO (South Africa) and MASTER-OAFA (Argentina) stations. Prompt optical emission was detected by MASTER-SAAO 38 s after the alert, which dimmed from a magnitude (white-light) of ∼10-16.2 mag over a period of ∼10 ks, followed by a plateau phase lasting ∼10 ks and then a decline to ∼18 mag after 80 ks. The light curve shows complex structure, with four or five distinct breaks in the power-law decline rate. SALT/RSS linear spectropolarimetry of the afterglow began ∼2.9 h after the burst, during the early part of the plateau phase of the light curve. Absorption lines seen at ∼6010 and 5490 Å are identified with the Mg ii 2799 Å line from the host galaxy at z = 1.15 and an intervening system located at z = 0.96. The mean linear polarization measured over 3400-8000 Å was ∼1.5 per cent and the mean equatorial position angle (θ) was ∼65°. VLT/FORS2 spectropolarimetry was obtained ∼10 h post-burst, during a period of slow decline (α = -0.44), and the polarization was measured to be p = 1.2 per cent and θ = 60°. Two observations with the MeerKAT radio telescope, taken 30 and 444 d after the GRB trigger, detected radio emission from the host galaxy only. We interpret the light curve and polarization of this long GRB in terms of a slow-cooling forward shock. © 2021 The Author(s) Published by Oxford University Press on behalf of Royal Astronomical Society., Some of the observations presented here were obtained with SALT under programme 2018-2-LSP-001 (PI: DAHB), which is supported by Poland under grant no. MNiSW DIR/WK/2016/07. Based on observations collected at the European Southern Observatory under ESO programme 0104.D-0600(C). DAHB and JT acknowledge support through the National Research Foundation (NRF) of South Africa. MB is supported by the South African Research Chairs Initiative (grant no. 64789) of the Department of Science and Innovation and the NRF.5 DMH acknowledges financial support from the NRF and the SAAO. SR is partially supported by NRF with grant no. 111749 (CPRR) and by a University of Johannesburg Research Council grant. DAK acknowledges support from Spanish National Research Project RTI2018-098104-J-I00 (GRBPhot). NPMK acknowledges support by the UK Space Agency. MASTER (equipment) is supported by Lomonosov Moscow State University Development Program. VL and DV are supported by RFBR grant 19-29-11011. CGM acknowledges financial support from Hiroko and Jim Sherwin. We thank the Director and staff of SARAO for supporting our MeerKAT DDT observation. The MeerKAT telescope is operated by the South African Radio Astronomy Observatory (SARAO), which is a facility of the National Research Foundation, an agency of the Department of Science and Innovation. Based on observations made with the SALT and the MeerKAT radio telescope array., With funding from the Spanish government through the Severo Ochoa Centre of Excellence accreditation SEV-2017-0709.
Published: 2021

20. Metrological assessment of DC current comparator resistance bridges

Author: M. Marzano, P.P. Capra, C. Cassiago, V. D’Elia, E. Gasparotto, and L. Callegaro
Subjects: Applied Mathematics, Electrical and Electronic Engineering, Condensed Matter Physics, Instrumentation
Published: 2023

21. A blast from the infant Universe: the very high-z GRB 210905A

Author: A. Rossi, D. D. Frederiks, D. A. Kann, M. De Pasquale, E. Pian, G. Lamb, P. D’Avanzo, L. Izzo, A. J. Levan, D. B. Malesani, A. Melandri, A. Nicuesa Guelbenzu, S. Schulze, R. Strausbaugh, N. R. Tanvir, L. Amati, S. Campana, A. Cucchiara, G. Ghirlanda, M. Della Valle, S. Klose, R. Salvaterra, R. L. C. Starling, G. Stratta, A. E. Tsvetkova, S. D. Vergani, A. D’Aì, D. Burgarella, S. Covino, V. D’Elia, A. de Ugarte Postigo, H. Fausey, J. P. U. Fynbo, F. Frontera, C. Guidorzi, K. E. Heintz, N. Masetti, E. Maiorano, C. G. Mundell, S. R. Oates, M. J. Page, E. Palazzi, J. Palmerio, G. Pugliese, A. Rau, A. Saccardi, B. Sbarufatti, D. S. Svinkin, G. Tagliaferri, A. J. van der Horst, D. J. Watson, M. V. Ulanov, K. Wiersema, D. Xu, J. Zhang, Galaxies, Etoiles, Physique, Instrumentation (GEPI), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut d'Astrophysique de Paris (IAP), Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Astrophysique Relativiste Théories Expériences Métrologie Instrumentation Signaux (ARTEMIS), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Ministerio de Ciencia e Innovación (España), European Commission, and European Research Council
Subjects: Astronomy, Astrophysics::High Energy Astrophysical Phenomena, gamma-ray burst: general, FOS: Physical sciences, gamma-ray burst: general, gamma-ray burst: individual: GRB 210915A, GRB HOST GALAXIES, Astrophysics::Cosmology and Extragalactic Astrophysics, general [gamma-ray burst], very high redshift, NO, GAMMA-RAY BURST, individual: GRB210905A [gamma-ray burst], STAR-FORMATION CLUES, PROMPT EMISSION, Astrophysics::Galaxy Astrophysics, SWIFT/BAT6 COMPLETE SAMPLE, High Energy Astrophysical Phenomena (astro-ph.HE), gamma-ray burst: individual: GRB210905A, very high redshift, Astronomy and Astrophysics, OPTICAL FLASH, JET OPENING ANGLE, AFTERGLOW LIGHT CURVES, Space and Planetary Science, X-RAY, gamma-ray burst: individual: GRB210905A, gamma-ray burst: individual: GRB 210915A, POPULATION III, Gamma-Ray Burst: Individual: GRB 210905A, Astrophysics - High Energy Astrophysical Phenomena, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract: Full list of authors: Rossi, A.; Frederiks, D. D.; Kann, D. A.; De Pasquale, M.; Pian, E.; Lamb, G.; D'Avanzo, P.; Izzo, L.; Levan, A. J.; Malesani, D. B.; Melandri, A.; Guelbenzu, A. Nicuesa; Schulze, S.; Strausbaugh, R.; Tanvir, N. R.; Amati, L.; Campana, S.; Cucchiara, A.; Ghirlanda, G.; Della Valle, M.; Klose, S.; Salvaterra, R.; Starling, R. L. C.; Stratta, G.; Tsvetkova, A. E.; Vergani, S. D.; D'Ai, A.; Burgarella, D.; Covino, S.; D'Elia, V; Postigo, A. de Ugarte; Fausey, H.; Fynbo, J. P. U.; Frontera, F.; Guidorzi, C.; Heintz, K. E.; Masetti, N.; Maiorano, F.; Mundell, C. G.; Oates, S. R.; Page, M. J.; Palazzi, E.; Palmerio, J.; Pugliese, G.; Rau, A.; Saccardi, A.; Sbarufatti, B.; Svinkin, D. S.; Tagliaferri, G.; van der Horst, A. J.; Watson, D. J.; Ulanov, M., V; Wiersema, K.; Xu, D.; Zhang, J.--This is an Open Access article, published by EDP Sciences, under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited., We present a detailed follow-up of the very energetic GRB 210905A at a high redshift of z = 6.312 and its luminous X-ray and optical afterglow. Following the detection by Swift and Konus-Wind, we obtained a photometric and spectroscopic follow-up in the optical and near-infrared (NIR), covering both the prompt and afterglow emission from a few minutes up to 20 Ms after burst. With an isotropic gamma-ray energy release of Eiso = 1.27−0.19+0.20 × 1054 erg, GRB 210905A lies in the top ∼7% of gamma-ray bursts (GRBs) in the Konus-Wind catalogue in terms of energy released. Its afterglow is among the most luminous ever observed, and, in particular, it is one of the most luminous in the optical at t ≳ 0.5 d in the rest frame. The afterglow starts with a shallow evolution that can be explained by energy injection, and it is followed by a steeper decay, while the spectral energy distribution is in agreement with slow cooling in a constant-density environment within the standard fireball theory. A jet break at ∼46.2 ± 16.3 d (6.3 ± 2.2 d rest-frame) has been observed in the X-ray light curve; however, it is hidden in the H band due to a constant contribution from the host galaxy and potentially from a foreground intervening galaxy. In particular, the host galaxy is only the fourth GRB host at z > 6 known to date. By assuming a number density n = 1 cm−3 and an efficiency η = 0.2, we derived a half-opening angle of 8.4 ° ±1.0°, which is the highest ever measured for a z ≳ 6 burst, but within the range covered by closer events. The resulting collimation-corrected gamma-ray energy release of ≃1 × 1052 erg is also among the highest ever measured. The moderately large half-opening angle argues against recent claims of an inverse dependence of the half-opening angle on the redshift. The total jet energy is likely too large to be sustained by a standard magnetar, and it suggests that the central engine of this burst was a newly formed black hole. Despite the outstanding energetics and luminosity of both GRB 210905A and its afterglow, we demonstrate that they are consistent within 2σ with those of less distant bursts, indicating that the powering mechanisms and progenitors do not evolve significantly with redshift. © A. Rossi et al. 2022., A. Rossi acknowledges support from the INAF project Premiale Supporto Arizona & Italia. D.D.F. and A.E.T. acknowledge support from RSF grant 21-12-00250. D.A.K. acknowledges support from Spanish National Research Project RTI2018-098104-J-I00 (GRBPhot). A.R., E.Pal., P.D.A., L.A., E.Pi., G.S., S.C., V.D.E., M.D.V., and A.M. acknowledge support from PRIN-MIUR 2017 (grant 20179ZF5KS). P.D.A., A.M. acknowledge support from the Italian Space Agency, contract ASI/INAF n. I/004/11/5. L.I. was supported by grants from VILLUM FONDEN (project number 16599 and 25501). D.B.M. and A.J.L. acknowledge the European Research Council (ERC) under the European Union’s Seventh Framework programme (FP7-2007-2013) (grant agreement No. 725246). The Cosmic Dawn Center (DAWN) is funded by the Danish National Research Foundation under grant No. 140. K.E.H. acknowledges support by a Postdoctoral Fellowship Grant (217690–051) from The Icelandic Research Fund. C.G.M. acknowledges financial support from Hiroko and Jim Sherwin. Part of the funding for GROND (both hardware as well as personnel) was generously granted from the Leibniz-Prize to Prof. G. Hasinger (DFG grant HA 1850/28-1). This work made use of data supplied by the UK Swift Science Data Centre at the University of Leicester., With funding from the Spanish government through the Severo Ochoa Centre of Excellence accreditation SEV-2017-0709.
Published: 2022

22. Dissecting the interstellar medium of a z=6.3 galaxy: X-shooter spectroscopy and HST imaging of the afterglow and environment of the Swift GRB 210905A

Author: A. Saccardi, S. D. Vergani, A. De Cia, V. D’Elia, K. E. Heintz, L. Izzo, J. T. Palmerio, P. Petitjean, A. Rossi, A. de Ugarte Postigo, L. Christensen, C. Konstantopoulou, A. J. Levan, D. B. Malesani, P. Møller, T. Ramburuth-Hurt, R. Salvaterra, N. R. Tanvir, C. C. Thöne, S. Vejlgaard, J. P. U. Fynbo, D. A. Kann, P. Schady, D. J. Watson, K. Wiersema, S. Campana, S. Covino, M. De Pasquale, H. Fausey, D. H. Hartmann, A. J. van der Horst, P. Jakobsson, E. Palazzi, G. Pugliese, S. Savaglio, R. L. C. Starling, G. Stratta, T. Zafar, HEP, INSPIRE, Ministerio de Ciencia e Innovación (España), and European Research Council
Subjects: High Energy Astrophysical Phenomena (astro-ph.HE), Galaxies: abundances, Galaxies: high-redshift, Gamma-ray burst: general, FOS: Physical sciences, Astronomy and Astrophysics, Dust, Extinction, Astrophysics - Astrophysics of Galaxies, Galaxies: ISM, Gamma-ray burst: individual: GRB 210905A, Space and Planetary Science, Astrophysics of Galaxies (astro-ph.GA), Astrophysics - High Energy Astrophysical Phenomena, [PHYS.ASTR] Physics [physics]/Astrophysics [astro-ph]
Abstract: Full list of authors: Saccardi, A.; Vergani, S. D.; De Cia, A.; D'Elia, V.; Heintz, K. E.; Izzo, L.; Palmerio, J. T.; Petitjean, P.; Rossi, A.; Postigo, A. de Ugarte; Christensen, L.; Konstantopoulou, C.; Levan, A. J.; Malesani, D. B.; Moller, P.; Ramburuth-Hurt, T.; Salvaterra, R.; Tanvir, N. R.; Thone, C. C.; Vejlgaard, S.; Fynbo, J. P. U.; Kann, D. A.; Schady, P.; Watson, D. J.; Wiersema, K.; Campana, S.; Covino, S.; De Pasquale, M.; Fausey, H.; Hartmann, D. H.; van der Horst, A. J.; Jakobsson, P.; Palazzi, E.; Pugliese, G.; Savaglio, S.; Starling, R. L. C.; Stratta, G.; Zafar, T.-- This is an Open Access article, published by EDP Sciences, under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited., The study of the properties of galaxies in the first billion years after the Big Bang is one of the major topics of current astrophysics. Optical and near-infrared spectroscopy of the afterglows of long gamma-ray bursts (GRBs) provides a powerful diagnostic tool to probe the interstellar medium (ISM) of their host galaxies and foreground absorbers, even up to the highest redshifts. We analyze the VLT/X-shooter afterglow spectrum of GRB 210905A, triggered by the Neil Gehrels Swift Observatory, and detect neutral hydrogen, low-ionization, high-ionization, and fine-structure absorption lines from a complex system at z = 6.3118, which we associate with the GRB host galaxy. We use them to study the ISM properties of the host system, revealing the metallicity, kinematics, and chemical abundance pattern of its gas along the GRB line of sight. We also detect absorption lines from at least two foreground absorbers at z = 5.7390 and z = 2.8296. The total metallicity of the z ∼ 6.3 system is [M/H]tot = −1.72 ± 0.13, after correcting for dust depletion and taking α-element enhancement into account, as suggested by our analysis. This is consistent with the values found for the other two GRBs at z ∼ 6 with spectroscopic data showing metal absorption lines (GRB 050904 and GRB 130606A), and it is at the higher end of the metallicity distribution of quasar damped Lyman-α systems (QSO-DLAs) extrapolated to such a high redshift. In addition, we determine the overall amount of dust and dust-to-metal mass ratio (DTM) ([Zn/Fe]fit = 0.33 ± 0.09 and DTM = 0.18 ± 0.03). We find indications of nucleosynthesis due to massive stars and, for some of the components of the gas clouds, we find evidence of peculiar nucleosynthesis, with an overabundance of aluminum (as also found for GRB 130606A). From the analysis of fine-structure lines, we determine distances of several kiloparsecs for the low-ionization gas clouds closest to the GRB. Those are farther distances than usually found for GRB host absorption systems, possibly due to the very high number of ionizing photons produced by the GRB that could ionize the line of sight up to several hundreds of parsecs. Using the HST/F140W image of the GRB field, we show the GRB host galaxy (with a possible afterglow contamination) as well as multiple objects within 2″ from the GRB position. We discuss the galaxy structure and kinematics that could explain our observations, also taking into account a tentative detection of Lyman-α emission at z = 6.3449 (∼1200 km s−1 from the GRB redshift in velocity space), and the observational properties of Lyman-α emitters at very high redshift. This study shows the amazing potential of GRBs to access detailed information on the properties (metal enrichment, gas kinematic, dust content, nucleosynthesis...) of very high-redshift galaxies, independently of the galaxy luminosity. Deep spectroscopic observations with VLT/MUSE and JWST will offer the unique possibility of combining the information presented in this paper with the properties of the ionized gas, with the goal of better understanding how galaxies in the reionization era form and evolve. © The Authors 2023., This work was supported by CNES. A.S. and S.D.V. acknowledge support from DIM-ACAV+. D.A.K. acknowledges support from Spanish National Research Project RTI2018-098104-J-I00 (GRBPhot). A.J.L. and D.B.M. are supported by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No. 725246). The Cosmic Dawn Center is funded by the Danish National Research Foundation under grant No. 140. NRT is supported by STFC consolidated grant ST/W000857/1. A.R., E.P., G.S. and S.S. acknowledge support from PRIN-MIUR 2017 (grant 20179ZF5KS). G.S. acknowledges the support by the State of Hesse within the Research Cluster ELEMENTS (Project ID 500/10.006)., With funding from the Spanish government through the "Severo Ochoa Centre of Excellence" accreditation (CEX2021-001131-S).
Published: 2022
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23. The supernova of the MAGIC gamma-ray burst GRB190114C

Author: A. Melandri, L. Izzo, E. Pian, D. B. Malesani, M. Della Valle, A. Rossi, P. D’Avanzo, D. Guetta, P. A. Mazzali, S. Benetti, N. Masetti, E. Palazzi, S. Savaglio, L. Amati, L. A. Antonelli, C. Ashall, M. G. Bernardini, S. Campana, R. Carini, S. Covino, V. D’Elia, A. de Ugarte Postigo, M. De Pasquale, A. V. Filippenko, A. S. Fruchter, J. P. U. Fynbo, A. Giunta, D. H. Hartmann, P. Jakobsson, J. Japelj, P. G. Jonker, D. A. Kann, G. P. Lamb, A. J. Levan, A. Martin-Carrillo, P. Møller, S. Piranomonte, G. Pugliese, R. Salvaterra, S. Schulze, R. L. C. Starling, L. Stella, G. Tagliaferri, N. Tanvir, D. Watson, European Commission, Ministerio de Ciencia e Innovación (España), Agenzia Spaziale Italiana, Villum Fonden, and Independent Research Fund Denmark
Subjects: astro-ph.HE, SPECTRUM, TELESCOPE, STAR, Astrophysics::High Energy Astrophysical Phenomena, Astronomy, DIVERSITY, Astronomy and Astrophysics, GRB, Astrophysics::Cosmology and Extragalactic Astrophysics, individual: GRB 190114C [Gamma-ray burst], FERMI, gamma-ray burst: individual: GRB 190114C, supernovae: individual: SN 2019jrj, LIGHT, Space and Planetary Science, JET, Supernovae: individual: SN 2019jrj, Astrophysics::Solar and Stellar Astrophysics, individual: SN 2019jrj [Supernovae], Gamma-ray burst: individual: GRB 190114C, Astrophysics::Galaxy Astrophysics
Abstract: Full list of authors: Melandri, A.; Izzo, L. ; Pian, E.; Malesani, D. B.; Della Valle, M.; Rossi, A.; D'Avanzo, P.; Guetta, D.; Mazzali, P. A.; Benetti, S.; Masetti, N.; Palazzi, E.; Savaglio, S.; Amati, L.; Antonelli, L. A.; Ashall, C.; Bernardini, M. G.; Campana, S.; Carini, R.; Covino, S.; D'Elia, V.; de Ugarte Postigo, A.; De Pasquale, M.; Filippenko, A. V.; Fruchter, A. S.; Fynbo, J. P. U.; Giunta, A.; Hartmann, D. H.; Jakobsson, P.; Japelj, J.; Jonker, P. G.; Kann, D. A.; Lamb, G. P.; Levan, A. J.; Martin-Carrillo, A.; Møller, P.; Piranomonte, S.; Pugliese, G.; Salvaterra, R.; Schulze, S.; Starling, R. L. C.; Stella, L.; Tagliaferri, G.; Tanvir, N.; Watson, D., We observed GRB 190114C (redshift z = 0.4245), the first gamma-ray burst (GRB) ever detected at TeV energies, at optical and near-infrared wavelengths with several ground-based telescopes and the Hubble Space Telescope, with the primary goal of studying its underlying supernova, SN 2019jrj. The monitoring spanned the time interval between 1.3 and 370 days after the burst, in the observer frame. We find that the afterglow emission can be modelled with a forward shock propagating in a uniform medium modified by time-variable extinction along the line of sight. A jet break could be present after 7 rest-frame days, and accordingly the maximum luminosity of the underlying supernova (SN) ranges between that of stripped-envelope core-collapse SNe of intermediate luminosity and that of the luminous GRB-associated SN 2013dx. The observed spectral absorption lines of SN 2019jrj are not as broad as in classical GRB SNe and are instead more similar to those of less-luminous core-collapse SNe. Taking the broad-lined stripped-envelope core-collapse SN 2004aw as an analogue, we tentatively derive the basic physical properties of SN 2019jrj. We discuss the possibility that a fraction of the TeV emission of this source might have had a hadronic origin and estimate the expected high-energy neutrino detection level with IceCube. © ESO 2022., A. M., M. G. B., P. D. A., S. C., and G. T. acknowledge support from ASI grant I/004/11/5. P. D. A., M. D. V., E. Pa., S. Sa., and S. P. acknowledge support from PRIN-MIUR 2017 (grant 20179ZF5KS). L. I. was supported by the VILLUM FONDEN (project numbers 16599 and 25501). D. B. M. acknowledges support from research grant 19054 from VILLUM FONDEN. A. V. F.'s research is supported by the Christopher R. Redlich Fund, the Miller Institute for Basic Research in Science (in which he is a Senior Miller Fellow), and many individual donors. D. A. K. acknowledges support from Spanish National Research Project RTI2018-098104-JI00 (GRBPhot). D. W. is supported by Independent Research Fund Denmark grant DFF-7014-00017. The Cosmic Dawn Center is supported by the Danish National Research Foundation under grant 140. A. R. acknowledges support from the project Supporto Arizona and Italia. The LBT is an international collaboration among institutions in the United States, Italy, and Germany. LBT Corporation partners are The University of Arizona on behalf of the Arizona Board of Regents; Istituto Nazionale di Astrofisica, Italy; LBT Beteiligungsgesellschaft, Germany, representing the Max-Planck Society, The Leibniz Institute for Astrophysics Potsdam, and Heidelberg University; The Ohio State University, representing OSU, University of Notre Dame, University of Minnesota, and University of Virginia. This work made use of data supplied by the UK Swift Science Data Centre at the University of Leicester., With funding from the Spanish government through the Severo Ochoa Centre of Excellence accreditation SEV-2017-0709.
Published: 2022

24. IoT technologies for wine supply chain traceability: Potential application in the Southern Apulia Region (Italy)

Author: G.P. Agnusdei, B. Coluccia, V. Elia, P.P. Miglietta, Agnusdei, G. P., Coluccia, B., Elia, V., and Miglietta, P. P.
Subjects: General Earth and Planetary Sciences, blockchain, counterfeiting, grape growers, NFC, RFID tags, winemakers, General Environmental Science
Abstract: The high value and volume of Italian wine production determines a strong stimulus for counterfeiting, which generates negative consequences for grape growers, winemakers and consumers. In this context, IoT technologies and the blockchain can serve as tools to ensure traceability, transparency and efficiency along the whole wine supply chain. Using primary data collected through interviews to the main grape growers and wineries involved in the wine supply chain in the Southern Apulia Region and secondary data, acquired from previous scientific literature, the study proposes a framework for the traceability and efficiency of the wine supply chain based on a combination of blockchain, Radio-Frequency Identification (RFID) and Near Field Communication (NFC) tags, Serial Shipping Container Codes (SSCC) and Quick Response (QR) codes. The developed framework allows for the systematic storage of information about commodities and processes throughout the supply chain, from grape growers to wine consumption and packaging disposal and/or reuse (forward and reverse flows). In addition, it ensures the transparency, safety, and security of all processes involved within the wine supply chain, serving as a quality information management tool. The information collected along the wine supply chain is entered into the management system by farmers, winemakers and bottlers and is accessible to all of them, while the distributors, consumers and the bottle reverse logistics operators, can only consult all of the information stored on the blockchain in order to know the origin, the quality, the processing and the authenticity of wines, without being able to enter data and/or modify the existent information.
Published: 2022

25. O uso adjuvante da imunoglobulina endovenosa no tratamento da sepse neonatal: uma revisão sistemática com metanálise

Author: Andréia C. B. F. Franco, Ariel C. Torrico, Fábio T. Moreira, Fernando P. Sá, Helena V. D'Elia, and Wanderley M. Bernardo
Subjects: Imunoglobulina endovenosa, sepse neonatal, choque séptico, sepse, infecção, recém-nascido, Pediatrics, RJ1-570
Abstract: OBJETIVO: Avaliar se a imunoglobulina endovenosa reduz a mortalidade e o tempo de internação no tratamento da sepse neonatal. FONTES DOS DADOS: A base de dados utilizada foi a MEDLINE. Os descritores, procurados por meio da ferramenta Medical Subject Headings, foram combinados na seguinte estratégia de busca: [(sepsis OR shock, septic OR infection) AND immunoglobulins, intravenous] AND infant, newborn. Apenas ensaios clínicos randomizados de boa qualidade e que avaliaram o efeito da imunoglobulina endovenosa adjuvante no tratamento da sepse neonatal foram selecionados. SÍNTESE DOS DADOS: Foram selecionados sete estudos para análise. Todos os estudos avaliaram a taxa de mortalidade, totalizando 3.756 pacientes. O efeito global desse desfecho revela que não há diferenças significativas entre os grupos avaliados. Apenas cinco estudos avaliaram o tempo médio de internação, contabilizando 3.672 pacientes. Embora o resultado final apresente uma redução estatisticamente significativa de 1,24 dias no tempo de internação no grupo da imunoglobulina endovenosa, essa diferença é clinicamente desprezível, e o alto custo não justifica o seu uso rotineiro na prática médica. Esses dados contradizem a revisão de Ohlsson et al., atualizada em 2010, que demonstrou diferença estatisticamente significativa entre os grupos, tanto no desfecho de mortalidade quanto no tempo médio de internação. CONCLUSÕES: Este estudo conclui que não há diferença significativa na taxa de mortalidade no uso adjuvante da imunoglobulina endovenosa no tratamento da sepse neonatal e que a diferença no tempo de internação é clinicamente desprezível.
Published: 2012
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26. Investigation of the correlation patterns and the Compton dominance variability of Mrk 421 in 2017

Author: Katsuaki Asano, I. Jiménez, A. Fuentes, C. M. Raiteri, D. Dominis Prester, E. Molina, E. Colombo, Y. V. Troitskaya, Nikola Godinovic, Sidika Merve Colak, Jenni Jormanainen, Yuki Iwamura, Alessandra Lamastra, Lab Saha, Antoniya Valcheva, Sunay Ibryamov, Elena G. Larionova, B. De Lotto, Evgeni Ovcharov, D. Zarić, Kazuma Ishio, David A. Green, M. Villata, D. Horan, Givi N. Kimeridze, Alexander Hahn, S. Nozaki, M. Perri, Michael D. Joner, D. Neise, S. Loporchio, R. J. García López, Marcello Giroletti, Victor A. Acciari, V. Fallah Ramazani, Tomohiko Oka, Daniela Dorner, Narek Sahakyan, J. Kushida, M. Kopp, Lorenzo Bellizzi, Noah Biederbeck, Joseph Moody, M. Gaug, L. Schneider, A. López-Oramas, Daniel Morcuende, N. Rizzi, Jose Luis Contreras, G. Vanzo, Rodolfo Carosi, L. Maraschi, Andrés Baquero, M. I. Carnerero, R. Iotov, Mosè Mariotti, A. Paravac, John Hoang, Ashwani Pandey, Z. R. Weaver, Francesco Longo, F. D'Ammando, S. Paiano, Elina Lindfors, Moritz Hütten, J. Herrera, Koji Noda, Abelardo Moralejo, Laura Eisenberger, E. Moretti, Julian Sitarek, Marcos López-Moya, Wlodek Bednarek, L. Di Venere, Ashot Chilingarian, U. Barres de Almeida, Elisa Bernardini, I. Agudo, M. Feige, R. Z. Ivanidze, O. A. Merkulova, D. Depaoli, M. Spencer, Massimo Persic, J. van Scherpenberg, Pratik Majumdar, L. Kunkel, K. Nishijima, Stefano Ansoldi, Juan Cortina, Kai Phillip Schmidt, A. Berti, Riccardo Paoletti, Saverio Lombardi, Daniel Mazin, M. V. Fonseca, Damir Lelas, R. J. C. Vera, Sanae Inoue, Giacomo D'Amico, Dominik Baack, C. Perennes, A. A. Nikiforova, Yating Chai, Stefan Cikota, G. M. Madejski, A. Arbet Engels, Daniel Kerszberg, Manuel Artero, E. Do Souto Espiñeira, Tomislav Terzić, J. Becerra González, Martin Makariev, R. Mirzoyan, Yoshiki Ohtani, G. A. Borman, Pawel Gliwny, Jose Miguel Miranda, A. De Angelis, Vitaly Neustroev, Wara Chamani, Oscar Blanch, T. S. Grishina, Martin Will, M. Vazquez Acosta, Nicola Giglietto, L. V. Larionova, Lea Heckmann, Francesco Gabriele Saturni, Jorge Otero-Santos, R. A. Chigladze, M. Balbo, N. Marchili, D. Hadasch, P. G. Prada Moroni, A. A. Vasilyev, M. G. Nikolashvili, Jordi Delgado, V. Ramakrishnan, Christian Fruck, G. Busetto, Victoria Moreno, Luca Tosti, A. Rugliancich, C. Nigro, Marina Manganaro, Valeri M. Larionov, M. Balokovic, Manuel Delfino, A. Strigachev, J. M. Paredes, Manash R. Samal, Stefano Covino, I. Vovk, H. C. Lin, Ž. Bošnjak, Stefano Menchiari, Rumen Bachev, Marc Ribó, Dorota Sobczyńska, Carolin Wunderlich, Bernd Schleicher, M. Minev, Antonio Stamerra, Maria-Isabel Bernardos, I. S. Troitskiy, Merja Tornikoski, E. N. Kopatskaya, Shunsuke Sakurai, Camilla Maggio, Chiara Righi, F. Verrecchia, P. Temnikov, S. G. Jorstad, T. Schweizer, Hidetoshi Kubo, Lluis Font, A. Y. Lien, Toshiaki Inada, A. Scherbantin, Lorand A. Sigua, G. Maneva, Stefano Truzzi, B. Machado de Oliveira Fraga, V. Bozhilov, M. Palatiello, Alessandro Marchini, Chaitanya Priyadarshi, Alessia Spolon, Léa Jouvin, Konstancja Satalecka, Tomoki Saito, Giovanni Ceribella, Michele Doro, S. O. Kurtanidze, Carlo Vigorito, Pablo Peñil, D. Strom, Giacomo Bonnoli, Adrian Biland, Ana Babić, Alicia Fattorini, D. Hildebrand, Satoshi Fukami, G. Ferrara, Y. Kajiwara, Matteo Cerruti, P. Da Vela, Vassil Verguilov, Lovro Pavletić, C. Delgado Mendez, Emilia Järvelä, S. Mićanović, Sergey S. Savchenko, Ivica Puljak, M. Noethe, Simone Mender, Francesco Dazzi, V. Vitale, Manuela Mallamaci, Ivana Batković, F. Leone, M. I. Martínez, J. Rico, Alan P. Marscher, C. Lorey, S. Ventura, Tjark Miener, Anne Lähteenmäki, David Paneque, Masahiro Teshima, Jarred Gershon Green, Wrijupan Bhattacharyya, Kari Nilsson, R. Walter, M. Strzys, D. Reinhart, E. Zaharieva, Wen Ping Chen, Vitalii Sliusar, Jürgen Besenrieder, Francesco Giordano, Antonio Tutone, Thomas Bretz, J. Buss, Alok C. Gupta, Simona Righini, O. M. Kurtanidze, Ciro Bigongiari, O. Vince, D. Elsaesser, C. Leto, M. Garczarczyk, Sargis Gasparyan, J. Kania, Dario Hrupec, R. López-Coto, Wolfgang Rhode, I. Snidaric, D. A. Morozova, Vladimir A. Hagen-Thorn, Mitsunari Takahashi, J. A. Acosta-Pulido, E. Prandini, Marie Karjalainen, D. Miceli, Goran Damljanović, Evgeni Semkov, Alice Donini, L. A. Antonelli, J. A. Barrio, Y. Suda, D. Carosati, V. D'Elia, Fabrizio Tavecchio, A. C. Sadun, Tihomir Surić, C. Casadio, Karl Mannheim, Santiago Ubach, Y. Kobayashi, F. Di Pierro, European Commission, European Research Council, Ministerio de Ciencia e Innovación (España), Generalitat de Catalunya, Federal Ministry of Education and Research (Germany), German Research Foundation, Swiss National Science Foundation, Croatian Science Foundation, Ministry of Education, Science and Technological Development (Serbia), Bulgarian National Science Fund, National Aeronautics and Space Administration (US), Acciari, V. A., Ansoldi, S., Antonelli, L. A., Arbet Engels, A., Artero, M., Asano, K., Babi??, A., Baquero, A., Barres de Almeida, U., Barrio, J. A., Batkovi??, I., Becerra Gonz??lez, J., Bednarek, W., Bellizzi, L., Bernardini, E., Bernardos, M., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Blanch, O., Bo??njak, ??., Busetto, G., Carosi, R., Ceribella, G., Cerruti, M., Chai, Y., Chilingarian, A., Cikota, S., Colak, S. M., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D???amico, G., D???elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Delfino, M., Delgado, J., Delgado Mendez, C., Depaoli, D., Di Pierro, F., Di Venere, L., Do Souto Espi??eira, E., Dominis Prester, D., Donini, A., Doro, M., Fallah Ramazani, V., Fattorini, A., Ferrara, G., Fonseca, M. V., Font, L., Fruck, C., Fukami, S., Garc??a L??pez, R. J., Garczarczyk, M., Gasparyan, S., Gaug, M., Giglietto, N., Giordano, F., Gliwny, P., Godinovi??, N., Green, J. G., Green, D., Hadasch, D., Hahn, A., Heckmann, L., Herrera, J., Hoang, J., Hrupec, D., H??tten, M., Inada, T., Inoue, S., Ishio, K., Iwamura, Y., Jim??nez, I., Jormanainen, J., Jouvin, L., Kajiwara, Y., Karjalainen, M., Kerszberg, D., Kobayashi, Y., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Lombardi, S., Longo, F., L??pez-Coto, R., L??pez-Moya, M., L??pez-Oramas, A., Loporchio, S., Machado de Oliveira Fraga, B., Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Maraschi, L., Mariotti, M., Mart??nez, M., Mazin, D., Menchiari, S., Mender, S., Mi??anovi??, S., Miceli, D., Miener, T., Minev, M., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Morcuende, D., Moreno, V., Moretti, E., Neustroev, V., Nigro, C., Nilsson, K., Nishijima, K., Noda, K., Nozaki, S., Ohtani, Y., Oka, T., Otero-Santos, J., Paiano, S., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Pavleti??, L., Pe??il, P., Perennes, C., Persic, M., Prada Moroni, P. G., Prandini, E., Priyadarshi, C., Puljak, I., Rib??, M., Rico, J., Righi, C., Rugliancich, A., Saha, L., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Saturni, F. G., Schmidt, K., Schweizer, T., Sitarek, J., nidari??, I., Sobczynska, D., Spolon, A., Stamerra, A., Strom, D., Strzys, M., Suda, Y., Suri??, T., Takahashi, M., Tavecchio, F., Temnikov, P., Terzi??, T., Teshima, M., Tosti, L., Truzzi, S., Tutone, A., Ubach, S., van Scherpenberg, J., Vanzo, G., Vazquez Acosta, M., Ventura, S., Verguilov, V., Vigorito, C. F., Vitale, V., Vovk, I., Will, M., Wunderlich, C., Zari??, D., Baack, D., Balbo, M., Biederbeck, N., Biland, A., Bretz, T., Buss, J., Dorner, D., Eisenberger, L., Elsaesser, D., Hildebrand, D., Iotov, R., Mannheim, K., Neise, D., Noethe, M., Paravac, A., Rhode, W., Schleicher, B., Sliusar, V., Walter, R., D???ammando, F., Horan, D., Lien, A. Y., Balokovi??, M., Madejski, G. M., Perri, M., Verrecchia, F., Leto, C., L??hteenm??ki, A., Tornikoski, M., Ramakrishnan, V., J??rvel??, E., Vera, R. J. C., Chamani, W., Villata, M., Raiteri, C. M., Gupta, A. C., Pandey, A., Fuentes, A., Agudo, I., Casadio, C., Semkov, E., Ibryamov, S., Marchini, A., Bachev, R., Strigachev, A., Ovcharov, E., Bozhilov, V., Valcheva, A., Zaharieva, E., Damljanovic, G., Vince, O., Larionov, V. M., Borman, G. A., Grishina, T. S., Hagen-Thorn, V. A., Kopatskaya, E. N., Larionova, E. G., Larionova, L. V., Morozova, D. A., Nikiforova, A. A., Savchenko, S. S., Troitskiy, I. S., Troitskaya, Y. V., Vasilyev, A. A., Merkulova, O. A., Chen, W. P., Samal, M., Lin, H. C., Moody, J. W., Sadun, A. C., Jorstad, S. G., Marscher, A. P., Weaver, Z. R., Feige, M., Kania, J., Kopp, M., Kunkel, L., Reinhart, D., Scherbantin, A., Schneider, L., Lorey, C., Acosta-Pulido, J. A., Carnerero, M. I., Carosati, D., Kurtanidze, S. O., Kurtanidze, O. M., Nikolashvili, M. G., Chigladze, R. A., Ivanidze, R. Z., Kimeridze, G. N., Sigua, L. A., Joner, M. D., Spencer, M., Giroletti, M., Marchili, N., Righini, S., Rizzi, N., Bonnoli, G., Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), MAGIC, FACT, Department of Electronics and Nanoengineering, Aalto-yliopisto, and Aalto University
Subjects: electron, PARTICLE-ACCELERATION, ELECTRON ACCELERATION, Radiation mechanisms: non-thermal, RAY, VHE [gamma ray], galaxies: active, BL Lacertae objects: individual: Mrk 421, radiation mechanisms: non-thermal, Electron, Astrophysics, GeV, 01 natural sciences, 7. Clean energy, LARGE-AREA TELESCOPE, law.invention, OBSERVATIONS, law, ultraviolet, optical, MAGIC (telescope), correlation [flux], 010303 astronomy & astrophysics, X-ray: flux, model: leptonic, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), BL-LACERTAE, individual: Mrk 421 [BL Lacertae objects], flux [X-ray], Gamma ray, flux: correlation, Galaxies: active, non-thermal [radiation mechanisms], Synchrotron, SWIFT OBSERVATIONS, active [galaxies], Spectral energy distribution, Física nuclear, Astrophysics - High Energy Astrophysical Phenomena, Lorentz, Flare, LOG-PARABOLIC SPECTRA, ACTIVE GALACTIC NUCLEI, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, radiation, mechanisms: non-thermal, LIGHT CURVES, X-RAY, MULTIWAVELENGTH, GLAST, leptonic [model], blazar, 0103 physical sciences, TeV, Blazar, 010308 nuclear & particles physics, Astronomy and Astrophysics, MAGIC, gamma ray: VHE, Space and Planetary Science, ddc:520, spectral, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Fermi Gamma-ray Space Telescope
Abstract: Full list of authors: Acciari, V. A.; Ansoldi, S.; Antonelli, L. A.; Arbet Engels, A.; Artero, M.; Asano, K.; Babić, A.; Baquero, A.; Barres de Almeida, U.; Barrio, J. A.; Batković, I.; Becerra González, J.; Bednarek, W.; Bellizzi, L.; Bernardini, E.; Bernardos, M.; Berti, A.; Besenrieder, J.; Bhattacharyya, W.; Bigongiari, C.; Blanch, O.; Bošnjak, Ž.; Busetto, G.; Carosi, R.; Ceribella, G.; Cerruti, M.; Chai, Y.; Chilingarian, A.; Cikota, S.; Colak, S. M.; Colombo, E.; Contreras, J. L.; Cortina, J.; Covino, S.; D'Amico, G.; D'Elia, V.; da Vela, P.; Dazzi, F.; de Angelis, A.; de Lotto, B.; Delfino, M.; Delgado, J.; Delgado Mendez, C.; Depaoli, D.; di Pierro, F.; di Venere, L.; Do Souto Espiñeira, E.; Dominis Prester, D.; Donini, A.; Doro, M.; Fallah Ramazani, V.; Fattorini, A.; Ferrara, G.; Fonseca, M. V.; Font, L.; Fruck, C.; Fukami, S.; García López, R. J.; Garczarczyk, M.; Gasparyan, S.; Gaug, M.; Giglietto, N.; Giordano, F.; Gliwny, P.; Godinović, N.; Green, J. G.; Green, D.; Hadasch, D.; Hahn, A.; Heckmann, L.; Herrera, J.; Hoang, J.; Hrupec, D.; Hütten, M.; Inada, T.; Inoue, S.; Ishio, K.; Iwamura, Y.; Jiménez, I.; Jormanainen, J.; Jouvin, L.; Kajiwara, Y.; Karjalainen, M.; Kerszberg, D.; Kobayashi, Y.; Kubo, H.; Kushida, J.; Lamastra, A.; Lelas, D.; Leone, F.; Lindfors, E.; Lombardi, S.; Longo, F.; López-Coto, R.; López-Moya, M.; López-Oramas, A.; Loporchio, S.; Machado de Oliveira Fraga, B.; Maggio, C.; Majumdar, P.; Makariev, M.; Mallamaci, M.; Maneva, G.; Manganaro, M.; Maraschi, L.; Mariotti, M.; Martínez, M.; Mazin, D.; Menchiari, S.; Mender, S.; Mićanović, S.; Miceli, D.; Miener, T.; Minev, M.; Miranda, J. M.; Mirzoyan, R.; Molina, E.; Moralejo, A.; Morcuende, D.; Moreno, V.; Moretti, E.; Neustroev, V.; Nigro, C.; Nilsson, K.; Nishijima, K.; Noda, K.; Nozaki, S.; Ohtani, Y.; Oka, T.; Otero-Santos, J.; Paiano, S.; Palatiello, M.; Paneque, D.; Paoletti, R.; Paredes, J. M.; Pavletić, L.; Peñil, P.; Perennes, C.; Persic, M.; Prada Moroni, P. G.; Prandini, E.; Priyadarshi, C.; Puljak, I.; Ribó, M.; Rico, J.; Righi, C.; Rugliancich, A.; Saha, L.; Sahakyan, N.; Saito, T.; Sakurai, S.; Satalecka, K.; Saturni, F. G.; Schmidt, K.; Schweizer, T.; Sitarek, J.; Šnidarić, I.; Sobczynska, D.; Spolon, A.; Stamerra, A.; Strom, D.; Strzys, M.; Suda, Y.; Surić, T.; Takahashi, M.; Tavecchio, F.; Temnikov, P.; Terzić, T.; Teshima, M.; Tosti, L.; Truzzi, S.; Tutone, A.; Ubach, S.; van Scherpenberg, J.; Vanzo, G.; Vazquez Acosta, M.; Ventura, S.; Verguilov, V.; Vigorito, C. F.; Vitale, V.; Vovk, I.; Will, M.; Wunderlich, C.; Zarić, D.; Baack, D.; Balbo, M.; Biederbeck, N.; Biland, A.; Bretz, T.; Buss, J.; Dorner, D.; Eisenberger, L.; Elsaesser, D.; Hildebrand, D.; Iotov, R.; Mannheim, K.; Neise, D.; Noethe, M.; Paravac, A.; Rhode, W.; Schleicher, B.; Sliusar, V.; Walter, R.; D'Ammando, F.; Horan, D.; Lien, A. Y.; Baloković, M.; Madejski, G. M.; Perri, M.; Verrecchia, F.; Leto, C.; Lähteenmäki, A.; Tornikoski, M.; Ramakrishnan, V.; Järvelä, E.; Vera, R. J. C.; Chamani, W.; Villata, M.; Raiteri, C. M.; Gupta, A. C.; Pandey, A.; Fuentes, A.; Agudo, I.; Casadio, C.; Semkov, E.; Ibryamov, S.; Marchini, A.; Bachev, R.; Strigachev, A.; Ovcharov, E.; Bozhilov, V.; Valcheva, A.; Zaharieva, E.; Damljanovic, G.; Vince, O.; Larionov, V. M.; Borman, G. A.; Grishina, T. S.; Hagen-Thorn, V. A.; Kopatskaya, E. N.; Larionova, E. G.; Larionova, L. V.; Morozova, D. A.; Nikiforova, A. A.; Savchenko, S. S.; Troitskiy, I. S.; Troitskaya, Y. V.; Vasilyev, A. A.; Merkulova, O. A.; Chen, W. P; Samal, M.; Lin, H. C.; Moody, J. W.; Sadun, A. C.; Jorstad, S. G.; Marscher, A. P.; Weaver, Z. R.; Feige, M.; Kania, J.; Kopp, M.; Kunkel, L.; Reinhart, D.; Scherbantin, A.; Schneider, L.; Lorey, C.; Acosta-Pulido, J. A.; Carnerero, M. I.; Carosati, D.; Kurtanidze, S. O.; Kurtanidze, O. M.; Nikolashvili, M. G.; Chigladze, R. A.; Ivanidze, R. Z.; Kimeridze, G. N.; Sigua, L. A.; Joner, M. D.; Spencer, M.; Giroletti, M.; Marchili, N.; Righini, S.; Rizzi, N.; Bonnoli, G.; MAGIC Collaboration; Fact Collaboration.-- This is an Open Access article, published by EDP Sciences, under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited., Aims. We present a detailed characterisation and theoretical interpretation of the broadband emission of the paradigmatic TeV blazar Mrk 421, with a special focus on the multi-band flux correlations. Methods. The dataset has been collected through an extensive multi-wavelength campaign organised between 2016 December and 2017 June. The instruments involved are MAGIC, FACT, Fermi-LAT, Swift, GASP-WEBT, OVRO, Medicina, and Metsahovi. Additionally, four deep exposures (several hours long) with simultaneous MAGIC and NuSTAR observations allowed a precise measurement of the falling segments of the two spectral components. Results. The very-high-energy (VHE; E 100 GeV) gamma rays and X-rays are positively correlated at zero time lag, but the strength and characteristics of the correlation change substantially across the various energy bands probed. The VHE versus X-ray fluxes follow dierent patterns, partly due to substantial changes in the Compton dominance for a few days without a simultaneous increase in the X-ray flux (i.e., orphan gamma-ray activity). Studying the broadband spectral energy distribution (SED) during the days including NuSTAR observations, we show that these changes can be explained within a one-zone leptonic model with a blob that increases its size over time. The peak frequency of the synchrotron bump varies by two orders of magnitude throughout the campaign. Our multi-band correlation study also hints at an anti-correlation between UV-optical and X-ray at a significance higher than 3. A VHE flare observed on MJD 57788 (2017 February 4) shows gamma-ray variability on multi-hour timescales, with a factor ten increase in the TeV flux but only a moderate increase in the keV flux. The related broadband SED is better described by a two-zone leptonic scenario rather than by a one-zone scenario.We find that the flare can be produced by the appearance of a compact second blob populated by high energetic electrons spanning a narrow range of Lorentz factors, from 0 min = 2104 to 0 max = 6105. © 2021 Georg Thieme Verlag. All rights reserved., The MAGIC Collaboration would like to thank the Instituto de Astrofísica de Canarias for the excellent working conditions at the Observatorio del Roque de los Muchachos in La Palma. The financial support of the German BMBF, MPG and HGF; the Italian INFN and INAF; the Swiss National Fund SNF; the ERDF under the Spanish Ministerio de Ciencia e Innovación (MICINN) (FPA2017-87859-P, FPA2017-85668-P, FPA2017-82729-C6-5-R, FPA2017-90566-REDC, PID2019-104114RB-C31, PID2019-104114RB-C32, PID2019-105510GB-C31,PID2019-107847RB-C41, PID2019-107847RB-C42, PID2019-107847RB-C44, PID2019-107988GB-C22); the Indian Department of Atomic Energy; the Japanese ICRR, the University of Tokyo, JSPS, and MEXT; the Bulgarian Ministry of Education and Science, National RI Roadmap Project DO1-268/16.12.2019 and the Academy of Finland grant nr. 320045 is gratefully acknowledged. This work was also supported by the Spanish Centro de Excelencia “Severo Ochoa” SEV-2016-0588, SEV-2017-0709 and CEX2019-000920-S, and “María de Maeztu” CEX2019-000918-M, the Unidad de Excelencia “María de Maeztu” MDM-2015-0509-18-2 and the “la Caixa” Foundation (fellowship LCF/BQ/PI18/11630012) and by the CERCA program of the Generalitat de Catalunya; by the Croatian Science Foundation (HrZZ) Project IP-2016-06-9782 and the University of Rijeka Project 13.12.1.3.02; by the DFG Collaborative Research Centers SFB823/C4 and SFB876/C3; the Polish National Research Centre grant UMO-2016/22/M/ST9/00382; and by the Brazilian MCTIC, CNPq and FAPERJ. The important contributions from ETH Zurich grants ETH-10.08-2 and ETH-27.12-1 as well as the funding by the Swiss SNF and the German BMBF (Verbundforschung Astro- und Astroteilchenphysik) and HAP (Helmoltz Alliance for Astroparticle Physics) are gratefully acknowledged. Part of this work is supported by Deutsche Forschungsgemeinschaft (DFG) within the Collaborative Research Center SFB 876 “Providing Information by Resource-Constrained Analysis”, project C3. We are thankful for the very valuable contributions from E. Lorenz, D. Renker and G. Viertel during the early phase of the project. We thank the Instituto de Astrofísica de Canarias for allowing us to operate the telescope at the Observatorio del Roque de los Muchachos in La Palma, the Max-Planck-Institut für Physik for providing us with the mount of the former HEGRA CT3 telescope, and the MAGIC collaboration for their support. The Fermi LAT Collaboration acknowledges generous ongoing support from a number of agencies and institutes that have supported both the development and the operation of the LAT as well as scientific data analysis. These include the National Aeronautics and Space Administration and the Department of Energy in the United States, the Commissariat à l’Energie Atomique and the Centre National de la Recherche Scientifique/Institut National de Physique Nucléaire et de Physique des Particules in France, the Agenzia Spaziale Italiana and the Istituto Nazionale di Fisica Nucleare in Italy, the Ministry of Education, Culture, Sports, Science and Technology (MEXT), High Energy Accelerator Research Organization (KEK) and Japan Aerospace Exploration Agency (JAXA) in Japan, and the K. A. Wallenberg Foundation, the Swedish Research Council and the Swedish National Space Board in Sweden. Additional support for science analysis during the operations phase is gratefully acknowledged from the Istituto Nazionale di Astrofisica in Italy and the Centre National d’Études Spatiales in France. This work performed in part under DOE Contract DE-AC02-76SF00515. This work made use of data from the NuSTAR mission, a project led by the California Institute of Technology, managed by the Jet Propulsion Laboratory, and funded by the National Aeronautics and Space Administration. We thank the NuSTAR Operations, Software, and Calibration teams for support with the execution and analysis of these observations. This research has made use of the NuSTAR Data Analysis Software (NuSTARDAS) jointly developed by the ASI Science Data Center (ASDC; Italy) and the California Institute of Technology (USA). This research has also made use of the XRT Data Analysis Software (XRTDAS) developed under the responsibility of the ASI Science Data Center (ASDC), Italy. A.A.E and D.P acknowledge support from the Deutsche Forschungs gemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy – EXC-2094 – 390783311. M. B. acknowledges support from the YCAA Prize Postdoctoral Fellowship and from the Black Hole Initiative at Harvard University, which is funded in part by the Gordon and Betty Moore Foundation (grant GBMF8273) and in part by the John Templeton Foundation. This publication makes use of data obtained at the Metsähovi Radio Observatory, operated by Aalto University in Finland. This research has made use of data from the OVRO 40-m monitoring program (Richards et al. 2011) which is supported in part by NASA grants NNX08AW31G, NNX11A043G, and NNX14AQ89G and NSF grants AST-0808050 and AST-1109911. I.A. acknowledges financial support from the Spanish “Ministerio de Ciencia e Innovación” (MCINN) through the “Center of Excellence Severo Ochoa” award for the Instituto de Astrofísica de Andalucía-CSIC (SEV-2017-0709). Acquisition and reduction of the MAPCAT data was supported in part by MICINN through grants AYA2016-80889-P and PID2019-107847RB-C44. The MAPCAT observations were carried out at the German-Spanish Calar Alto Observatory, which is jointly operated by Junta de Andalucía and Consejo Superior de Investigaciones Científicas. C.C. acknowledges support from the European Research Council (ERC) under the European Union Horizon 2020 research and innovation program under the grant agreement No 771282. This research was partially supported by the Bulgarian National Science Fund of the Ministry of Education and Science under grants KP-06-H28/3 (2018), KP-06-H38/4 (2019) and KP-06-KITAJ/2 (2020). We acknowledge support by Bulgarian National Science Fund under grant DN18-10/2017 and National RI Roadmap Projects DO1-277/16.12.2019 and DO1-268/16.12.2019 of the Ministry of Education and Science of the Republic of Bulgaria. This research was supported by the Ministry of Education, Science and Technological Development of the Republic of Serbia (contract No 451-03-68/2020-14/200002). G.D. acknowledges observing grant support from the Institute of Astronomy and Rozhen NAO BAS through the bilateral joint research project “Gaia Celestial Reference Frame (CRF) and fast variable astronomical objects” (2020–2022, head – G. Damljanovic). The BU group was supported in part by NASA Fermi guest investigator program grants 80NSSC19K1505 and 80NSSC20K1566. This study was based in part on observations conducted using the 1.8 m Perkins Telescope Observatory (PTO) in Arizona, which is owned and operated by Boston University. This article is partly based on observations made with the LCOGT Telescopes, one of whose nodes is located at the Observatorios de Canarias del IAC on the island of Tenerife in the Observatorio del Teide. This article is also based partly on data obtained with the STELLA robotic telescopes in Tenerife, an AIP facility jointly operated by AIP and IAC. The Abastumani team acknowledges financial support by the Shota Rustaveli National Science Foundation under contract FR-19-6174. Based on observations with the Medicina telescope operated by INAF – Istituto di Radioastronomia.
Published: 2021

27. First detection of VHE gamma-ray emission from TXS 1515-273, study of its X-ray variability and spectral energy distribution

Author: M. I. Martínez, V. Neustroev, Francesco Longo, Maria-Isabel Bernardos, Alessandro Marchini, Alicia Fattorini, Tomohiko Oka, Katsuaki Asano, U. Barres de Almeida, Damir Lelas, Adrian Biland, D. Hadasch, D. Miceli, Sanae Inoue, Giacomo D'Amico, Yating Chai, Stefan Cikota, Pawel Gliwny, I. Vovk, David A. Green, R. J. García López, Narek Sahakyan, Stefano Covino, Lea Heckmann, Francesco Gabriele Saturni, J. Becerra González, Armin Nabizadeh, F. D'Ammando, J. Rico, M. Vazquez Acosta, Nicola Giglietto, Alexander Hahn, Nikola Godinovic, Dorota Sobczyńska, G. Ferrara, G. Busetto, E. Molina, Satoshi Fukami, Shunsuke Sakurai, Jarred Gershon Green, Elisabetta Bissaldi, C. Perennes, D. Strom, Yusuke Suda, E. Colombo, Lab Saha, Alice Donini, Kazuma Ishio, Massimo Persic, L. A. Antonelli, Martin Makariev, Dominik Baack, P. G. Prada Moroni, J. Kushida, Ivica Puljak, Victor Moreno, Oscar Blanch, S. Ventura, C. Nigro, Carlo Vigorito, F. Leone, D. Dominis Prester, Alessandra Lamastra, J. A. Barrio, John Hoang, V. Verguilov, Tomoki Saito, J. M. Paredes, Antonio Stamerra, Giovanni Ceribella, Rodolfo Carosi, I. Jiménez, V. D'Elia, Pratik Majumdar, M. V. Fonseca, Daniel Morcuende, Jose Luis Contreras, Jenni Jormanainen, Vincenzo Vitale, T. Schweizer, A. Arbet Engels, S. Loporchio, A. Rugliancich, Marina Manganaro, A. De Angelis, M. Karjalainen, Sargis Gasparyan, Stefano Menchiari, Y. Kajiwara, Fabrizio Tavecchio, M. Palatiello, Manuela Mallamaci, Masahiro Teshima, S. Paiano, Luca Tosti, I. Snidaric, Mosè Mariotti, Martin Will, M. Orienti, S. Mićanović, Ashot Chilingarian, Wolfgang Rhode, Lluis Font, B. Machado de Oliveira Fraga, Tihomir Surić, Manuel Artero, Juan Cortina, Toshiaki Inada, Yuki Iwamura, Stefano Truzzi, D. Zarić, Saverio Lombardi, Francesco Dazzi, Simone Mender, E. Do Souto Espiñeira, Tomislav Terzić, Dario Hrupec, Pablo Peñil, Konstancja Satalecka, L. Maraschi, Giacomo Bonnoli, Sidika Merve Colak, Elina Lindfors, Marcos López-Moya, G. Maneva, Karl Mannheim, Wlodek Bednarek, L. Di Venere, Mitsunari Takahashi, Michele Doro, J. van Scherpenberg, Stefano Ansoldi, Daniel Mazin, Riccardo Paoletti, Christian Fruck, Ivana Batković, E. Prandini, Wrijupan Bhattacharyya, Julian Sitarek, Santiago Ubach, Y. Kobayashi, F. Di Pierro, Jürgen Besenrieder, Lorenzo Bellizzi, Francesco Giordano, Antonio Tutone, J. Otero-Santos, K. Nishijima, Jose Miguel Miranda, Kai Phillip Schmidt, A. Berti, Yoshiki Ohtani, Tjark Miener, David Paneque, D. Elsaesser, Jordi Delgado, Ž. Bošnjak, Matteo Cerruti, Chiara Righi, V. Fallah Ramazani, V. A. Acciari, P. Temnikov, P. Da Vela, Manuel Delfino, Lovro Pavletić, Moritz Hütten, Chaitanya Priyadarshi, Carolin Wunderlich, Ana Babić, C. Delgado Mendez, M. Strzys, Kari Nilsson, Camilla Maggio, Daniela Dorner, Gaia Vanzo, M. Gaug, J. Herrera, Koji Noda, Elisa Bernardini, Alessia Spolon, Léa Jouvin, A. López-Oramas, S. Cutini, Daniel Kerszberg, Marc Ribó, B. De Lotto, S. Nozaki, Andrés Baquero, Hidetoshi Kubo, Abelardo Moralejo, E. Moretti, D. Depaoli, Bernd Schleicher, M. Minev, R. Mirzoyan, Ciro Bigongiari, M. Garczarczyk, R. López-Coto, German Research Foundation, Swiss National Science Foundation, Ministerio de Ciencia, Innovación y Universidades (España), Department of Atomic Energy (India), Institute for Cosmic Ray Research (Japan), University of Tokyo, Japan Society for the Promotion of Science, Ministry of Education, Culture, Sports, Science and Technology (Japan), Ministry of Education and Research (Romania), Academy of Finland, La Caixa, Croatian Science Foundation, University of Rijeka, Polish National Agency for Academic Exchange, European Commission, Ministerio de Economía y Competitividad (España), Istituto Nazionale di Astrofisica, Acciari, Va, Ansoldi, S, Antonelli, La, Engels, Aa, Artero, M, Asano, K, Baack, D, Babic, A, Baquero, A, de Almeida, Ub, Barrio, Ja, Batkovic, I, Gonzalez, Jb, Bednarek, W, Bellizzi, L, Bernardini, E, Bernardos, M, Berti, A, Besenrieder, J, Bhattacharyya, W, Bigongiari, C, Biland, A, Blanch, O, Bosnjak, Z, Busetto, G, Carosi, R, Ceribell, G, Cerruti, M, Chai, Y, Chilingarian, A, Cikota, S, Colak, Sm, Colombo, E, Contreras, Jl, Cortina, J, Covino, S, D'Amico, G, D'Elia, V, Da Vela, P, Dazzi, F, De Angelis, A, De Lotto, B, Delfino, M, Delgado, J, Mendez, Cd, Depaoli, D, Di Pierro, F, Di Venere, L, Espineira, Ed, Prester, Dd, Donini, A, Dorner, D, Doro, M, Elsaesser, D, Ramazani, Vf, Fattorini, A, Ferrara, G, Fonseca, Mv, Font, L, Fruck, C, Fukami, S, Lopez, Rjg, Garczarczyk, M, Gasparyan, S, Gaug, M, Giglietto, N, Giordano, F, Gliwny, P, Godinovic, N, Green, Jg, Green, D, Hadasch, D, Hahn, A, Heckmann, L, Herrera, J, Hoang, J, Hrupec, D, Hutten, M, Inada, T, Inoue, S, Ishio, K, Iwamura, Y, Jimenez, I, Jormanainen, J, Jouvin, L, Kajiwara, Y, Karjalainen, M, Kerszberg, D, Kobayashi, Y, Kubo, H, Kushida, J, Lamastra, A, Lelas, D, Leone, F, Lindfors, E, Lombardi, S, Longo, F, Lopez-Coto, R, Lopez-Moya, M, Lopez-Oramas, A, Loporchio, S, Fraga, Bmd, Maggio, C, Majumdar, P, Makariev, M, Mallamaci, M, Maneva, G, Manganaro, M, Mannheim, K, Maraschi, L, Mariotti, M, Martinez, M, Mazin, D, Menchiari, S, Mender, S, Micanovic, S, Miceli, D, Miener, T, Minev, M, Miranda, Jm, Mirzoyan, R, Molina, E, Moralejo, A, Morcuende, D, Moreno, V, Moretti, E, Neustroev, V, Nigro, C, Nilsson, K, Nishijima, K, Noda, K, Nozaki, S, Ohtani, Y, Oka, T, Otero-Santos, J, Paiano, S, Palatiello, M, Paneque, D, Paoletti, R, Paredes, Jm, Pavletic, L, Penil, P, Perennes, C, Moroni, Pgp, Prandini, E, Priyadarshi, C, Puljak, I, Rhode, W, Ribo, M, Rico, J, Righi, C, Rugliancich, A, Saha, L, Sahakyan, N, Saito, T, Sakurai, S, Satalecka, K, Saturni, Fg, Schleicher, B, Schmidt, K, Schweizer, T, Sitarek, J, Snidaric, I, Sobczynska, D, Spolon, A, Stamerra, A, Strom, D, Strzys, M, Suda, Y, Suric, T, Takahashi, M, Tavecchio, F, Temnikov, P, Terzic, T, Teshima, M, Tosti, L, Truzzi, S, Tutone, A, Ubach, S, Vanscherpenberg, J, Vanzo, G, Acosta, Mv, Ventura, S, Verguilov, V, Vigorito, Cf, Vitale, V, Vovk, I, Will, M, Wunderlich, C, Zaric, D, Bissaldi, E, Bonnoli, G, Cutini, S, D'Ammando, F, Nabizadeh, A, Marchini, A, and Orienti, M
Subjects: Photon, 010504 meteorology & atmospheric sciences, active [Galaxies], Radiation mechanisms: non-thermal, Astrophysics::High Energy Astrophysical Phenomena, galaxies: active, Objects: individual: TXS 1515–273, FOS: Physical sciences, Flux, Astrophysics, 01 natural sciences, 7. Clean energy, law.invention, law, objects: individual: TXS 1515-273, 0103 physical sciences, individual: TXS 1515-273 [Objects], MAGIC (telescope), Blazar, 010303 astronomy & astrophysics, 0105 earth and related environmental sciences, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, non-thermal [Radiation mechanisms], individual: TXS 1515–273 [objects], Gamma ray, Astronomy and Astrophysics, Synchrotron, Crab Nebula, Space and Planetary Science, ddc:520, Spectral energy distribution, Física nuclear, objects: individual: TXS 1515–273, Astrophysics - High Energy Astrophysical Phenomena
Abstract: Full list of authors: Acciari, V. A.; Ansoldi, S.; Antonelli, L. A.; Arbet Engels, A. ; Artero, M.; Asano, K.; Baack, D.; Babić, A.; Baquero, A.; Barres de Almeida, U.; Barrio, J. A.; Batković, I.; Becerra González, J.; Bednarek, W.; Bellizzi, L.; Bernardini, E.; Bernardos, M.; Berti, A.; Besenrieder, J.; Bhattacharyya, W.; Bigongiari, C.; Biland, A.; Blanch, O.; Bošnjak, Ž.; Busetto, G.; Carosi, R.; Ceribella, G.; Cerruti, M.; Chai, Y.; Chilingarian, A.; Cikota, S.; Colak, S. M.; Colombo, E.; Contreras, J. L.; Cortina, J.; Covino, S.; D'Amico, G.; D'Elia, V.; da Vela, P.; Dazzi, F.; de Angelis, A.; de Lotto, B.; Delfino, M.; Delgado, J.; Delgado Mendez, C.; Depaoli, D.; Pierro, F. Di; Venere, L. Di; Do Souto Espiñeira, E.; Dominis Prester, D.; Donini, A.; Dorner, D.; Doro, M.; Elsaesser, D.; Fallah Ramazani, V.; Fattorini, A.; Ferrara, G.; Fonseca, M. V.; Font, L.; Fruck, C.; Fukami, S.; García López, R. J.; Garczarczyk, M.; Gasparyan, S.; Gaug, M.; Giglietto, N.; Giordano, F.; Gliwny, P.; Godinović, N.; Green, J. G.; Green, D.; Hadasch, D.; Hahn, A.; Heckmann, L.; Herrera, J.; Hoang, J.; Hrupec, D.; Hütten, M.; Inada, T.; Inoue, S.; Ishio, K.; Iwamura, Y.; Jiménez, I.; Jormanainen, J.; Jouvin, L.; Kajiwara, Y.; Karjalainen, M.; Kerszberg, D.; Kobayashi, Y.; Kubo, H.; Kushida, J.; Lamastra, A.; Lelas, D.; Leone, F.; Lindfors, E.; Lombardi, S.; Longo, F.; López-Coto, R.; López-Moya, M.; López-Oramas, A.; Loporchio, S.; Machado de Oliveira Fraga, B.; Maggio, C.; Majumdar, P.; Makariev, M.; Mallamaci, M.; Maneva, G.; Manganaro, M.; Mannheim, K.; Maraschi, L.; Mariotti, M.; Martínez, M.; Mazin, D.; Menchiari, S.; Mender, S.; Mićanović, S.; Miceli, D.; Miener, T.; Minev, M.; Miranda, J. M.; Mirzoyan, R.; Molina, E.; Moralejo, A.; Morcuende, D.; Moreno, V.; Moretti, E.; Neustroev, V.; Nigro, C.; Nilsson, K.; Nishijima, K.; Noda, K.; Nozaki, S.; Ohtani, Y.; Oka, T.; Otero-Santos, J.; Paiano, S.; Palatiello, M.; Paneque, D.; Paoletti, R.; Paredes, J. M.; Pavletić, L.; Peñil, P.; Perennes, C.; Persic, M.; Prada Moroni, P. G.; Prandini, E.; Priyadarshi, C.; Puljak, I.; Rhode, W.; Ribó, M.; Rico, J.; Righi, C.; Rugliancich, A.; Saha, L.; Sahakyan, N.; Saito, T.; Sakurai, S.; Satalecka, K.; Saturni, F. G.; Schleicher, B.; Schmidt, K.; Schweizer, T.; Sitarek, J.; Šnidarić, I.; Sobczynska, D.; Spolon, A.; Stamerra, A.; Strom, D.; Strzys, M.; Suda, Y.; Surić, T.; Takahashi, M.; Tavecchio, F.; Temnikov, P.; Terzić, T.; Teshima, M.; Tosti, L.; Truzzi, S.; Tutone, A.; Ubach, S.; van Scherpenberg, J.; Vanzo, G.; Vazquez Acosta, M.; Ventura, S.; Verguilov, V.; Vigorito, C. F.; Vitale, V.; Vovk, I.; Will, M.; Wunderlich, C.; Zarić, D.; Bissaldi, E.; Bonnoli, G.; Cutini, S.; D'Ammando, F.; Nabizadeh, A.; Marchini, A.; Orienti, M.; MAGIC Collaboration., We report here on the first multiwavelength (MWL) campaign on the blazar TXS 1515-273, undertaken in 2019 and extending from radio to very-high-energy gamma-rays (VHE). Up until now, this blazar had not been the subject of any detailed MWL observations. It has a rather hard photon index at GeV energies and was considered a candidate extreme high-synchrotron-peaked source. MAGIC observations resulted in the first-time detection of the source in VHE with a statistical significance of 7.6σ. The average integral VHE flux of the source is 6 ± 1 per cent of the Crab nebula flux above 400 GeV. X-ray coverage was provided by Swift-XRT, XMM-Newton, and NuSTAR. The long continuous X-ray observations were separated by ∼9 h, both showing clear hour scale flares. In the XMM-Newton data, both the rise and decay time-scales are longer in the soft X-ray than in the hard X-ray band, indicating the presence of a particle cooling regime. The X-ray variability time-scales were used to constrain the size of the emission region and the strength of the magnetic field. The data allowed us to determine the synchrotron peak frequency and classify the source as a flaring high, but not extreme synchrotron-peaked object. Considering the constraints and variability patterns from the X-ray data, we model the broad-band spectral energy distribution. We applied a simple one-zone model, which could not reproduce the radio emission and the shape of the optical emission, and a two-component leptonic model with two interacting components, enabling us to reproduce the emission from radio to VHE band. © 2021 The Author(s) Published by Oxford University Press on behalf of Royal Astronomical Society., The financial support of the German BMBF, MPG, and HGF; the Italian INFN and INAF; the Swiss National Fund SNF; the ERDF under the Spanish Ministerio de Ciencia e Innovacion (MICINN) (FPA201787859-P, FPA2017-85668-P, FPA2017-82729-C6-5-R, FPA201790566-REDC, PID2019-104114RB-C31, PID2019-104114RB-C32, PID2019-105510GB-C31, PID2019-107847RB-C41, PID2019107847RB-C42, PID2019-107847RB-C44, PID2019-107988GBC22); the Indian Department of Atomic Energy; the Japanese ICRR, the University of Tokyo, JSPS, and MEXT; the Bulgarian Ministry of Education and Science, National RI Roadmap Project DO1268/16.12.2019 and the Academy of Finland grant nr. 317637 and 320045 are gratefully acknowledged. This work was also supported by the Spanish Centro de Excelencia `Severo Ochoa' SEV-20160588, SEV-2017-0709 and CEX2019-000920-S, and `Maria de Maeztu' CEX2019-000918-M, the Unidad de Excelencia `Maria de Maeztu' MDM-2015-0509-18-2 and the `la Caixa' Foundation (fellowshipLCF/BQ/PI18/11630012), by the Croatian Science Foundation (HrZZ) Project IP-2016-06-9782 and the University of Rijeka Project 13.12.1.3.02, by the DFG Collaborative Research Centers SFB823/C4 and SFB876/C3, the Polish National Research Centre grant UMO-2016/22/M/ST9/00382 and by the Brazilian MCTIC, CNPq, and FAPERJ. The Fermi-LAT Collaboration acknowledges generous ongoing support from a number of agencies and institutes that have supported both the development and the operation of the LAT as well as scientific data analysis. These include the National Aeronautics and Space Administration and the Department of Energy in the United States, theCommissariat à l'Energie Atomique and the Centre National de la Recherche Scientifique/Institut National de Physique Nucleaire et de Physique des Particules in France, the Agenzia Spaziale Italiana and the Istituto Nazionale di Fisica Nucleare in Italy, the Ministry of Education, Culture, Sports, Science and Technology (MEXT), High Energy Accelerator Research Organization (KEK) and Japan Aerospace Exploration Agency (JAXA) in Japan, and the K. A. Wallenberg Foundation, the Swedish Research Council and the Swedish National Space Board in Sweden. Additional support for science analysis during the operations phase from the following agencies is also gratefully acknowledged: the Istituto Nazionale di Astrofisica in Italy and the Centre National d'Etudes Spatiales in France.
Published: 2021

28. Swift follow-up of gravitational wave triggers: results from the first aLIGO run and optimization for the future

Author: P. A. Evans, J. A. Kennea, D. M. Palmer, M. Bilicki, J. P. Osborne, P. T. O'Brien, N. R. Tanvir, A. Y. Lien, S. D. Barthelmy, D. N. Burrows, S. Campana, S. B. Cenko, V. D'Elia, N. Gehrels, F. E. Marshall, K. L. Page, M. Perri, B. Sbarufatti, M. H. Siegel, G. Tagliaferri, and E. Troja
Subjects: Astronomy
Abstract: During its first observing run, in late 2015, the advanced Laser Interferometer Gravitational-wave Observatory facility announced three gravitational wave (GW) triggers to electromagnetic follow-up partners. Two of these have since been confirmed as being of astrophysical origin: both are binary black hole mergers at ∼500 Mpc; the other trigger was later found not to be astrophysical. In this paper, we report on the Swift follow-up observations of the second and third triggers, including details of 21 X-ray sources detected; none of which can be associated with the GW event. We also consider the challenges that the next GW observing run will bring as the sensitivity and hence typical distance of GW events will increase. We discuss how to effectively use galaxy catalogues to prioritize areas for follow-up, especially in the presence of distance estimates from the GW data. We also consider two galaxy catalogues and suggest that the high completeness at larger distances of the 2MASS Photometric Redshift catalogue makes it very well suited to optimize Swift follow-up observations.
Published: 2016
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29. Exploitation of the bilosome platform technology to formulate antibiotics and enhance efficacy of melioidosis treatments

Author: Yvonne Perrie, Craig W. Roberts, Swapnil Khadke, Wendy Butcher, Stuart Woods, Jonathan McGahon, E. Diane Williamson, and Riccardo V. D'Elia
Subjects: RM, Burkholderia pseudomallei, Melioidosis, medicine.drug_class, Antibiotics, Administration, Oral, Pharmaceutical Science, Levofloxacin, 02 engineering and technology, Microbiology, Bile Acids and Salts, Mice, 03 medical and health sciences, Drug Delivery Systems, medicine, Animals, Microbiome, Adverse effect, 030304 developmental biology, Doxycycline, Mice, Inbred BALB C, 0303 health sciences, biology, business.industry, 021001 nanoscience & nanotechnology, Antimicrobial, biology.organism_classification, medicine.disease, Anti-Bacterial Agents, bacteria, Female, 0210 nano-technology, business, medicine.drug
Abstract: Burkholderia pseudomallei is a Gram-negative intracellular bacterium which is recalcitrant to antibiotic therapy. There also is currently no licensed vaccine for this potentially fatal pathogen, further highlighting the requirement for better therapeutics to treat the disease melioidosis. Here we use an oral delivery platform, the bilosome to entrap already- licensed antibiotics. Bilosome-entrapped antibiotics were used to treat mice infected via the aerosol route with B. pseudomallei. When treatment was started by the oral route at 6 h post-infection and continued for 7 days, bilosome levofloxacin and bilosome doxycycline formulations were significantly more efficacious than free antibiotics in terms of survival rates. Additionally, bilosome formulated levofloxacin protected mice from antibiotic and infection induced weight loss following B. pseudomallei infection. The microbiomes of mice treated with levofloxacin were depleted of all phyla with the exception of Firmicutes, but doxycycline treatment had minimal effect on the microbiome. Encapsulation of either drug in bilosomes had no deleterious or clear advantageous effect on microbiome. This indicates that the ability of bilosomes to ameliorate antibiotic induced weight loss is not due to microbiome effects. The bilosome platform not only has potential to reduce adverse effects of orally delivered antimicrobials, but has potential for other therapeutics which may cause detrimental side-effects or require enhanced delivery.
Published: 2019

30. A STUDY ON THE CHANGES IN PHYSICAL PROPERTIES OF DEMINERALIZED WATER PUT IN CONTACT WITH POROUS HYDROPHILIC MATERIALS: EXPERIMENTAL EVIDENCES ON METABRICK MATERIAL

Author: Roberto Germano, E. Napoli, V. Elia, Giovanna Vessia, and Patrizio Signanini
Subjects: Materials science, Mechanics of Materials, Capillary action, Electrical resistivity and conductivity, Mechanical Engineering, Modeling and Simulation, Biomedical Engineering, General Materials Science, Composite material, Condensed Matter Physics, Porosity
Published: 2019

31. Author Correction: Proton acceleration in thermonuclear nova explosions revealed by gamma rays

Author: V. A. Acciari, S. Ansoldi, L. A. Antonelli, A. Arbet Engels, M. Artero, K. Asano, D. Baack, A. Babić, A. Baquero, U. Barres de Almeida, J. A. Barrio, I. Batković, J. Becerra González, W. Bednarek, L. Bellizzi, E. Bernardini, M. Bernardos, A. Berti, J. Besenrieder, W. Bhattacharyya, C. Bigongiari, A. Biland, O. Blanch, H. Bökenkamp, G. Bonnoli, Ž. Bošnjak, G. Busetto, R. Carosi, G. Ceribella, M. Cerruti, Y. Chai, A. Chilingarian, S. Cikota, S. M. Colak, E. Colombo, J. L. Contreras, J. Cortina, S. Covino, G. D’Amico, V. D’Elia, P. Da Vela, F. Dazzi, A. De Angelis, B. De Lotto, A. Del Popolo, M. Delfino, J. Delgado, C. Delgado Mendez, D. Depaoli, F. Di Pierro, L. Di Venere, E. Do Souto Espiñeira, D. Dominis Prester, A. Donini, D. Dorner, M. Doro, D. Elsaesser, V. Fallah Ramazani, L. Fariña Alonso, A. Fattorini, M. V. Fonseca, L. Font, C. Fruck, S. Fukami, Y. Fukazawa, R. J. García López, M. Garczarczyk, S. Gasparyan, M. Gaug, N. Giglietto, F. Giordano, P. Gliwny, N. Godinović, J. G. Green, D. Green, D. Hadasch, A. Hahn, T. Hassan, L. Heckmann, J. Herrera, J. Hoang, D. Hrupec, M. Hütten, T. Inada, K. Ishio, Y. Iwamura, I. Jiménez Martínez, J. Jormanainen, L. Jouvin, D. Kerszberg, Y. Kobayashi, H. Kubo, J. Kushida, A. Lamastra, D. Lelas, F. Leone, E. Lindfors, L. Linhoff, S. Lombardi, F. Longo, R. López-Coto, M. López-Moya, A. López-Oramas, S. Loporchio, B. Machado de Oliveira Fraga, C. Maggio, P. Majumdar, M. Makariev, M. Mallamaci, G. Maneva, M. Manganaro, K. Mannheim, L. Maraschi, M. Mariotti, M. Martínez, A. Mas Aguilar, D. Mazin, S. Menchiari, S. Mender, S. Mićanović, D. Miceli, T. Miener, J. M. Miranda, R. Mirzoyan, E. Molina, A. Moralejo, D. Morcuende, V. Moreno, E. Moretti, T. Nakamori, L. Nava, V. Neustroev, M. Nievas Rosillo, C. Nigro, K. Nilsson, K. Nishijima, K. Noda, S. Nozaki, Y. Ohtani, T. Oka, J. Otero-Santos, S. Paiano, M. Palatiello, D. Paneque, R. Paoletti, J. M. Paredes, L. Pavletić, P. Peñil, M. Persic, M. Pihet, P. G. Prada Moroni, E. Prandini, C. Priyadarshi, I. Puljak, W. Rhode, M. Ribó, J. Rico, C. Righi, A. Rugliancich, N. Sahakyan, T. Saito, S. Sakurai, K. Satalecka, F. G. Saturni, B. Schleicher, K. Schmidt, T. Schweizer, J. Sitarek, I. Šnidarić, D. Sobczynska, A. Spolon, A. Stamerra, J. Strišković, D. Strom, M. Strzys, Y. Suda, T. Surić, M. Takahashi, R. Takeishi, F. Tavecchio, P. Temnikov, T. Terzić, M. Teshima, L. Tosti, S. Truzzi, A. Tutone, S. Ubach, J. van Scherpenberg, G. Vanzo, M. Vazquez Acosta, S. Ventura, V. Verguilov, C. F. Vigorito, V. Vitale, I. Vovk, M. Will, C. Wunderlich, T. Yamamoto, D. Zarić, F. Ambrosino, M. Cecconi, G. Catanzaro, C. Ferrara, A. Frasca, M. Munari, L. Giustolisi, J. Alonso-Santiago, M. Giarrusso, U. Munari, and P. Valisa
Subjects: Astronomy and Astrophysics
Published: 2022

32. Protection against Experimental Melioidosis following Immunisation with a Lipopolysaccharide-Protein Conjugate

Author: Andrew E. Scott, Sarah A. Ngugi, Thomas R. Laws, David Corser, Claire L. Lonsdale, Riccardo V. D’Elia, Richard W. Titball, E. Diane Williamson, Timothy P. Atkins, and Joann L. Prior
Subjects: Immunologic diseases. Allergy, RC581-607
Abstract: Melioidosis is a severe infectious disease caused by Burkholderia pseudomallei. It is refractory to antibiotic treatment and there is currently no licensed vaccine. In this report we detail the construction and protective efficacy of a polysaccharide-protein conjugate composed of B. pseudomallei lipopolysaccharide and the Hc fragment of tetanus toxin. Immunisation of mice with the lipopolysaccharide-conjugate led to significantly reduced bacterial burdens in the spleen 48 hours after challenge and afforded significant protection against a lethal challenge with B. pseudomallei. The conjugate generated significantly higher levels of antigen-specific IgG1 and IgG2a than in lipopolysaccharide-immunised mice. Immunisation with the conjugate also demonstrated a bias towards Th1 type responses, evidenced by high levels of IgG2a. In contrast, immunisation with unconjugated lipopolysaccharide evoked almost no IgG2a demonstrating a bias towards Th2 type responses. This study demonstrates the effectiveness of this approach in the development of an efficacious and protective vaccine against melioidosis.
Published: 2014
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33. The peculiar short-duration GRB 200826A and its supernova

Author: A. Rossi, B. Rothberg, E. Palazzi, D. A. Kann, P. D’Avanzo, L. Amati, S. Klose, A. Perego, E. Pian, C. Guidorzi, A. S. Pozanenko, S. Savaglio, G. Stratta, G. Agapito, S. Covino, F. Cusano, V. D’Elia, M. De Pasquale, M. Della Valle, O. Kuhn, L. Izzo, E. Loffredo, N. Masetti, A. Melandri, P. Y. Minaev, A. Nicuesa Guelbenzu, D. Paris, S. Paiano, C. Plantet, F. Rossi, R. Salvaterra, S. Schulze, C. Veillet, A. A. Volnova, Ministerio de Ciencia e Innovación (España), European Commission, Agenzia Spaziale Italiana, and German Research Foundation
Subjects: LIGHT CURVES, High Energy Astrophysical Phenomena (astro-ph.HE), PRE-SWIFT, KILONOVA, FOS: Physical sciences, Astronomy and Astrophysics, NEUTRON-STAR MERGERS, I, GAMMA-RAY BURST, HOST GALAXIES, LONG, Supernovae, MG II ABSORBERS, Space and Planetary Science, Core-collapse supernovae, Gamma-ray bursts, COMPLETE SAMPLE, Astrophysics - High Energy Astrophysical Phenomena
Abstract: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited., Gamma-ray bursts (GRBs) are classified into long and short events. Long GRBs (LGRBs) are associated with the end states of very massive stars, while short GRBs (SGRBs) are linked to the merger of compact objects. GRB 200826A was a peculiar event, because by definition it was an SGRB, with a rest-frame duration of ∼0.5 s. However, this event was energetic and soft, which is consistent with LGRBs. The relatively low redshift (z = 0.7486) motivated a comprehensive, multiwavelength follow-up campaign to characterize its host, search for a possible associated supernova (SN), and thus understand the origin of this burst. To this aim we obtained a combination of deep near-infrared (NIR) and optical imaging together with spectroscopy. Our analysis reveals an optical and NIR bump in the light curve whose luminosity and evolution are in agreement with several SNe associated to LGRBs. Analysis of the prompt GRB shows that this event follows the Ep,i–Eiso relation found for LGRBs. The host galaxy is a low-mass star-forming galaxy, typical of LGRBs, but with one of the highest star formation rates, especially with respect to its mass ($\mathrm{log}{M}_{* }/{M}_{\odot }=8.6$, SFR ∼ 4.0 M⊙ yr−1). We conclude that GRB 200826A is a typical collapsar event in the low tail of the duration distribution of LGRBs. These findings support theoretical predictions that events produced by collapsars can be as short as 0.5 s in the host frame and further confirm that duration alone is not an efficient discriminator for the progenitor class of a GRB. © 2022. The Author(s). Published by the American Astronomical Society., A.R. acknowledges support from the INAF project Premiale Supporto Arizona & Italia. B.R. would like to acknowledge the assistance and support of R. T. Gatto. D.A.K. acknowledges support from Spanish National Research Project RTI2018-098104-J-I00 (GRBPhot). P.D'A. acknowledges funding from the Italian Space Agency, contract ASI/INAF No. I/004/11/4. L.I. was supported by two grants from VILLUM FONDEN (project No. 16599 and 25501). A.N.G. and S.K. acknowledge financial support from grants DFG Kl 766/16-3, DFG Kl 766/18-1, and DFG RA 2484/1-3. A.N.G. acknowledges support from Thüringer Landessternwarte Tautenburg. A.S.P., P.Y.M., and A.A.V. acknowledge support from RSF grant 18-12-00378. S.S. acknowledges support from the G.R.E.A.T. research environment, funded by Vetenskapsrådet, the Swedish Research Council, project No. 2016-06012. A.R., E.Pi., P.D'A., L.A., A.P., E.Pa., S.S., G.S., S.C., V.D'E., M.D.V., and A.M. acknowledge support from PRIN-MIUR 2017 (grant 20179ZF5KS). The LBT is an international collaboration among institutions in the United States, Italy, and Germany. The LBT Corporation partners are the University of Arizona on behalf of the Arizona Board of Regents; Istituto Nazionale di Astrofisica, Italy; LBT Beteiligungsgesellschaft, Germany, representing the Max-Planck Society, the Leibniz Institute for Astrophysics Potsdam, and Heidelberg University; and the Ohio State University, representing OSU, University of Notre Dame, University of Minnesota, and University of Virginia. This work made use of data supplied by the UK Swift Science Data Centre at the University of Leicester., With funding from the Spanish government through the Severo Ochoa Centre of Excellence accreditation SEV-2017-0709.
Published: 2021
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34. H.e.s.s. And magic observations of a sudden cessation of a very-high-energy γ -ray flare in PKS 1510-089 in May 2016

Author: A. Yusafzai, J. van Scherpenberg, M. Büchele, B. Boccardi, S. Caroff, S. J. Fegan, Daniela Dorner, T. Schweizer, Mosè Mariotti, Gaia Vanzo, Tom Armstrong, Nu. Komin, Pratik Majumdar, M. V. Fonseca, Matteo Cerruti, A. Lemiere, F. Eichhorn, J. Devin, C. Trichard, Michael Punch, Stefano Gabici, M. Palatiello, V. A. Acciari, F. Schüssler, Sylvia Zhu, P. J. Meintjes, Werner Hofmann, Samuel Timothy Spencer, Y. Kajiwara, J. Zorn, D. Dominis Prester, S. Bonnefoy, Constantin Steppa, G. Maurin, Adrian Biland, J. M. Paredes, Antonio Stamerra, U. Barres de Almeida, Tadayuki Takahashi, Damir Lelas, Victor Doroshenko, Davide Depaoli, Dmitriy Kostunin, R. Mirzoyan, T. Surić, D. Gottschall, M. Füßling, Moritz Hütten, Lea Heckmann, M. Gaug, J. Herrera, Ullrich Schwanke, C. Arcaro, H. Abdalla, Lorenzo Bellizzi, Thomas P. Krichbaum, Francesco Dazzi, John Hoang, Martin Will, Dominik Baack, L. Maraschi, Elina Lindfors, M. A. Kastendieck, R. Rauth, V. Baghmanyan, D. Ninci, Koji Noda, Michael Backes, S. Raab, Sanae Inoue, Giacomo D'Amico, Manuel Meyer, Q. Remy, L. Olivera-Nieto, Dorota Sobczyńska, Elisa Bernardini, M. Filipovic, Riaan Steenkamp, Davit Zargaryan, Hambeleleni Ndiyavala, Stefan Klepser, G. Vasileiadis, G. Lamanna, S. G. Jorstad, Daniel Mazin, Jacek Niemiec, Kirsty Feijen, Alessandro Montanari, Tim Holch, Seiya Nozaki, Anna Barnacka, M. Hörbe, Giacomo Bonnoli, D. Strom, T. Tavernier, Takeshi Oka, Axel Donath, J. Rico, A. W. Chen, J. Dyks, T. Chand, Jim Hinton, F. Niederwanger, Olaf Reimer, Daniel Kerszberg, Manuel Delfino, Krzysztof Katarzynski, Ivica Puljak, S. Sailer, Dmitry Khangulyan, Christian Fruck, Gavin Rowell, D. A. Sanchez, Maria Haupt, Julian Sitarek, Alan P. Marscher, Stefano Truzzi, Pablo Peñil, E. O. Angüner, Catherine Boisson, S. Ventura, Dieter Horns, M. Bryan, V. Barbosa Martins, L. Sun, Rachel Simoni, Gerard Fontaine, Jacco Vink, P. Reichherzer, Jim Davies, G. Hermann, Regis Terrier, Clemens Hoischen, A. A. Zdziarski, G. Ferrara, Francois Brun, G. Emery, M. de Bony de Lavergne, P. Vincent, Kyoshi Nishijima, Alessandra Lamastra, G. Fichet de Clairfontaine, E. de Oña Wilhelmi, P. Munar-Adrover, Yoshiki Ohtani, Carlo Romoli, Jordi Delgado, Wrijupan Bhattacharyya, L. Di Venere, D. Zarić, Zorawar Wadiasingh, F. Di Pierro, Ž. Bošnjak, Hester Schutte, Isak Delberth Davids, Roberta Zanin, Karl Mannheim, M. Strzys, Łukasz Stawarz, R. J. Tuffs, V. Fallah Ramazani, B. Bi, Marc Ribó, Sabrina Casanova, H. Prokoph, A. Carosi, Stefano Covino, D. J. van der Walt, Thomas Murach, Yating Chai, Saša Mićanović, Jae-Young Kim, V. Vitale, Francesco Longo, R. Konno, Alicia Fattorini, Narek Sahakyan, Y. A. Gallant, R. J. García López, Junko Kushida, Jürgen Besenrieder, Dario Hrupec, P. Da Vela, S. Steinmassl, P. G. Prada Moroni, Jonathan Mackey, Rafal Moderski, Stefan Cikota, Hidetoshi Kubo, Armelle Jardin-Blicq, Monica Barnard, J. Otero-Santos, Mischa Breuhaus, J. Becerra González, Yu. W. Wong, V. Joshi, Samuel Zouari, N. Shafi, Natalia Żywucka, E. Prandini, M. A. Lopez, Gianluca Giavitto, Katsuaki Asano, Mitsunari Takahashi, T. Vuillaume, M. Curyło, P. Morris, K. Egberts, Stefano Ansoldi, M. de Naurois, Pawel Gliwny, L. Pavletić, C. Moore, Alessia Spolon, M. Vazquez Acosta, D. Elsaesser, Tomoki Saito, Giovanni Ceribella, Riccardo Paoletti, Celine Armand, Jhilik Majumdar, Stefan Ohm, G. Busetto, Léa Jouvin, Ana Babić, Frank M. Rieger, A. Dmytriiev, Dorit Glawion, Z. R. Weaver, Włodek Kluźniak, S. Chandra, V. Marandon, A. Djannati-Ataï, E. Moulin, Tomasz Bulik, Alessio Berti, M. Seglar-Arroyo, H. Odaka, Christian Stegmann, Stefan Wagner, C. Perennes, Pierre Brun, Yasunobu Uchiyama, A. Fiasson, U. Colin, David A. Green, Kazuma Ishio, A. Arbet Engels, A. De Angelis, Wlodek Bednarek, Nikola Godinovic, F. Ait Benkhali, Vassil Verguilov, Camilla Maggio, L. Mohrmann, Jean-Pierre Ernenwein, M. Spir-Jacob, M. Karjalainen, Vitaly Neustroev, P. deWilt, M. Scalici, Victoria Moreno, A. Priyana Noel, A. López-Oramas, M. Lemoine-Goumard, N. Torres-Albà, Martin Makariev, C. van Rensburg, Oscar Blanch, S. Pita, Alexander Hahn, V. Sahakian, Yusuke Suda, S. Schwemmer, Thomas Lohse, Misao Sasaki, Daniel Morcuende, Johannes Veh, D. Jankowsky, Michael Kreter, D. Berge, Luca Tosti, R. Marx, F. Werner, V. Poireau, Andrea Santangelo, C. Nigro, Andreas Quirrenbach, Jose Luis Contreras, E. Ruiz-Velasco, Thomas Bylund, M. Tluczykont, V. D'Elia, A. S. Seyffert, Jose Miguel Miranda, Massimo Persic, L. Dirson, Efthalia Traianou, Carlo Vigorito, Sargis Gasparyan, Y. Kobayashi, Jacques Muller, Jeffrey A. Hodgson, Marek Jamrozy, Christoph Deil, I. Jung-Richardt, Joachim Hahn, Mohanraj Senniappan, A. Rugliancich, Marina Manganaro, K. Nakashima, Kleopas Shiningayamwe, Alice Donini, Michelle Tsirou, Yuki Iwamura, G. Maneva, L. A. Antonelli, Juan Cortina, Markus Holler, Michal Ostrowski, Wolfgang Rhode, L. Rinchiuso, Felix Jankowsky, Sebastian Panny, M. I. Martínez, Michael Zacharias, Ferdinando Giordano, Felix Aharonian, Lluis Font, J.-P. Lenain, Merja Tornikoski, B. Machado de Oliveira Fraga, M.-H. Grondin, Lenka Tomankova, Markus Böttcher, Alison Mitchell, Chiara Righi, E. Do Souto Espiñeira, Tomislav Terzić, Alexandre Marcowith, P. Temnikov, Helene Sol, Sabrina Einecke, Iryna Lypova, Toshiaki Inada, Rodolfo Carosi, R. D. Parsons, Yvonne Becherini, Shunsuke Sakurai, L. Giunti, A. Nayerhoda, Arnaud Mares, Chaitanya Priyadarshi, Satoshi Fukami, Konstancja Satalecka, Stefan Funk, Johan Bregeon, Sidika Merve Colak, Alicja Wierzcholska, R. J. White, F. Leone, Michele Doro, D. Huber, Carolina Casadio, Anne Lähteenmäki, Masahiro Teshima, Domenico Tiziani, D. Malyshev, M. Panter, U. Katz, Heinrich J. Völk, G. Martí-Devesa, C. Levy, M. Renaud, J. A. Barrio, Kai Phillip Schmidt, L. Oakes, N. Giglietto, Simone Mender, Paolo Marchegiani, Ashot Chilingarian, Tjark Miener, James E. M. Watson, David Paneque, J. Bolmont, Manuela Mallamaci, Halim Ashkar, A. Sinha, Fabrizio Tavecchio, Kari Nilsson, B. van Soelen, B. Rudak, R. Adam, D. Miceli, M. Mohamed, Saverio Lombardi, E. Molina, P. T. O'Brien, E. Colombo, Lab Saha, Luca Foffano, C. van Eldik, G. Peron, Garret Cotter, D. Hadasch, D. A. Prokhorov, K. Kosack, Konrad Bernlöhr, B. Peyaud, I. Vovk, G. Pühlhofer, A. Reimer, J. F. Glicenstein, Bruno Khelifi, Serena Loporchio, I. Snidaric, Abelardo Moralejo, Andreas Specovius, E. Moretti, Bernd Schleicher, M. Minev, B. De Lotto, Andrés Baquero, A.M. Taylor, J. Damascene Mbarubucyeye, Christo Venter, Ciro Bigongiari, A. Zech, M. Garczarczyk, R. López-Coto, Q. Piel, Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire Univers et Théories (LUTH (UMR_8102)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Laboratoire Univers et Particules de Montpellier (LUPM), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), H.E.S.S., MAGIC, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), German Research Foundation, Istituto Nazionale di Fisica Nucleare, Istituto Nazionale di Astrofisica, Swiss National Science Foundation, Ministerio de Economía y Competitividad (España), Department of Atomic Energy (India), Academy of Finland, University of Tokyo, La Caixa, Croatian Science Foundation, University of Rijeka, Polish National Agency for Academic Exchange, Abdalla, H., Adam, R., Aharonian, F., Ait Benkhali, F., Ang??ner, E. O., Arcaro, C., Armand, C., Armstrong, T., Ashkar, H., Backes, M., Baghmanyan, V., Barbosa Martins, V., Barnacka, A., Barnard, M., Becherini, Y., Berge, D., Bernl??hr, K., Bi, B., B??ttcher, M., Boisson, C., Bolmont, J., Bonnefoy, S., de Bony de Lavergne, M., Bregeon, J., Breuhaus, M., Brun, F., Brun, P., Bryan, M., B??chele, M., Bulik, T., Bylund, T., Caroff, S., Carosi, A., Casanova, S., Chand, T., Chandra, S., Chen, A., Cotter, G., Cury??o, M., Damascene Mbarubucyeye, J., Davids, I. D., Davies, J., Deil, C., Devin, J., Dewilt, P., Dirson, L., Djannati-Ata??, A., Dmytriiev, A., Donath, A., Doroshenko, V., Dyks, J., Egberts, K., Eichhorn, F., Einecke, S., Emery, G., Ernenwein, J. -P., Feijen, K., Fegan, S., Fiasson, A., Fichet de Clairfontaine, G., Filipovic, M., Fontaine, G., Funk, S., F????ling, M., Gabici, S., Gallant, Y. A., Giavitto, G., Giunti, L., Glawion, D., Glicenstein, J. F., Gottschall, D., Grondin, M. -H., Hahn, J., Haupt, M., Hermann, G., Hinton, J. A., Hofmann, W., Hoischen, C., Holch, T. L., Holler, M., H??rbe, M., Horns, D., Huber, D., Jamrozy, M., Jankowsky, D., Jankowsky, F., Jardin-Blicq, A., Joshi, V., Jung-Richardt, I., Kastendieck, M. A., Katarzy??ski, K., Katz, U., Khangulyan, D., Kh??lifi, B., Klepser, S., Klu??niak, W., Komin, Nu., Konno, R., Kosack, K., Kostunin, D., Kreter, M., Lamanna, G., Lemi??re, A., Lemoine-Goumard, M., Lenain, J. -P., Levy, C., Lohse, T., Lypova, I., Mackey, J., Majumdar, J., Malyshev, D., Marandon, V., Marchegiani, P., Marcowith, A., Mares, A., Mart??-Devesa, G., Marx, R., Maurin, G., Meintjes, P. J., Meyer, M., Mitchell, A. M. W., Moderski, R., Mohamed, M., Mohrmann, L., Montanari, A., Moore, C., Morris, P., Moulin, E., Muller, J., Murach, T., Nakashima, K., Nayerhoda, A., de Naurois, M., Ndiyavala, H., Niederwanger, F., Niemiec, J., Oakes, L., O???brien, P., Odaka, H., Ohm, S., Olivera-Nieto, L., de Ona Wilhelmi, E., Ostrowski, M., Panter, M., Panny, S., Parsons, R. D., Peron, G., Peyaud, B., Piel, Q., Pita, S., Poireau, V., Priyana Noel, A., Prokhorov, D. A., Prokoph, H., P??hlhofer, G., Punch, M., Quirrenbach, A., Raab, S., Rauth, R., Reichherzer, P., Reimer, A., Reimer, O., Remy, Q., Renaud, M., Rieger, F., Rinchiuso, L., Romoli, C., Rowell, G., Rudak, B., Ruiz-Velasco, E., Sahakian, V., Sailer, S., Sanchez, D. A., Santangelo, A., Sasaki, M., Scalici, M., Sch??ssler, F., Schutte, H. M., Schwanke, U., Schwemmer, S., Seglar-Arroyo, M., Senniappan, M., Seyffert, A. S., Shafi, N., Shiningayamwe, K., Simoni, R., Sinha, A., Sol, H., Specovius, A., Spencer, S., Spir-Jacob, M., Stawarz, ??., Sun, L., Steenkamp, R., Stegmann, C., Steinmassl, S., Steppa, C., Takahashi, T., Tavernier, T., Taylor, A. M., Terrier, R., Tiziani, D., Tluczykont, M., Tomankova, L., Trichard, C., Tsirou, M., Tuffs, R., Uchiyama, Y., van der Walt, D. J., van Eldik, C., van Rensburg, C., van Soelen, B., Vasileiadis, G., Veh, J., Venter, C., Vincent, P., Vink, J., V??lk, H. 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P., Boccardi, B., Casadio, C., Hodgson, J., Kim, J. -Y., Krichbaum, T. P., L??hteenm??ki, A., Tornikoski, M., Traianou, E., Weaver, Z. R., Gravitation and Astroparticle Physics Amsterdam, High Energy Astrophys. & Astropart. Phys (API, FNWI), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Montpellier 2 - Sciences et Techniques (UM2), Department of Electronics and Nanoengineering, Aalto-yliopisto, and Aalto University
Subjects: non-thermal, quasars: individual: PKS 1510−089, galaxies: active, relativistic processes, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Astrophysics of Galaxies [radiation mechanisms], Photon, individual: PKS 1510−089 [quasars], Astrophysics::High Energy Astrophysical Phenomena, Flux, radiation mechanisms: non-thermal / quasars: individual: PKS 1510−089 / galaxies: active / relativistic processes, radiation mechanisms: non-thermal, quasars: individual: PKS 1510-089, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, law.invention, law, 0103 physical sciences, Galaxies: Active, Quasars: Individual: Pks 1510-089, Radiation mechanisms: Non-thermal, Relativistic processes, individual: PKS 1510-089 [quasars], MAGIC (telescope), 010303 astronomy & astrophysics, Physics, [PHYS]Physics [physics], 010308 nuclear & particles physics, Astronomy and Astrophysics, Quasar, Light curve, non-thermal [radiation mechanisms], relativistic processes [radiation mechanisms], Extragalactic background light, Space and Planetary Science, active [galaxies], ddc:520, Física nuclear, quasars: individual: PKS 1510��089, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Fermi Gamma-ray Space Telescope, Flare
Abstract: The flat spectrum radio quasar (FSRQ) PKS 1510−089 is known for its complex multiwavelength behaviour and it is one of only a few FSRQs detected in very-high-energy (VHE, E > 100 GeV) γ rays. The VHE γ-ray observations with H.E.S.S. and MAGIC in late May and early June 2016 resulted in the detection of an unprecedented flare, which revealed, for the first time, VHE γ-ray intranight variability for this source. While a common variability timescale of 1.5 h has been found, there is a significant deviation near the end of the flare, with a timescale of ∼20 min marking the cessation of the event. The peak flux is nearly two orders of magnitude above the low-level emission. For the first time, a curvature was detected in the VHE γ-ray spectrum of PKS 1510–089, which can be fully explained by the absorption on the part of the extragalactic background light. Optical R-band observations with ATOM revealed a counterpart of the γ-ray flare, even though the detailed flux evolution differs from the VHE γ-ray light curve. Interestingly, a steep flux decrease was observed at the same time as the cessation of the VHE γ-ray flare. In the high-energy (HE, E > 100 MeV) γ-ray band, only a moderate flux increase was observed with Fermi-LAT, while the HE γ-ray spectrum significantly hardens up to a photon index of 1.6. A search for broad-line region (BLR) absorption features in the γ-ray spectrum indicates that the emission region is located outside of the BLR. Radio very-long-baseline interferometry observations reveal a fast-moving knot interacting with a standing jet feature around the time of the flare. As the standing feature is located ∼50 pc from the black hole, the emission region of the flare may have been located at a significant distance from the black hole. If this is indeed a true correlation, the VHE γ rays must have been produced far down in the jet, where turbulent plasma crosses a standing shock., Astronomy & Astrophysics, 648, ISSN:0004-6361, ISSN:1432-0746
Published: 2021

35. Broadband Multi-wavelength Properties of M87 during the 2017 Event Horizon Telescope Campaign

Author: Masanori Nakamura, R. Shang, Abelardo Moralejo, A. Rugliancich, Marina Manganaro, Jun Liu, Monika Moscibrodzka, Andreas Specovius, V. Ramakrishnan, S. O'Brien, Michal Ostrowski, Luis C. Ho, Sera Markoff, D. Depaoli, I. Jung-Richardt, Manel Errando, Chiara Righi, S. Panny, Toshiaki Inada, Alexandra J. Tetarenko, Daniela Dorner, Norbert Wex, Nimesh A. Patel, Olivier Hervet, C. Arcaro, Alasdair E. Gent, Yu Wun Wong, Gaia Vanzo, Pierre Brun, Konstancja Satalecka, Stefan Funk, Lorenzo Bellizzi, Michael Lindqvist, Michele Doro, Felix Jankowsky, P. Kaaret, Nicholas R. MacDonald, Lang Cui, P. Temnikov, S. Patel, Sabrina Einecke, Manuel Artero, E. Moretti, Hope Boyce, M. Gaug, Charles F. Gammie, Iryna Lypova, Gisela N. Ortiz-León, Felix Aharonian, Colin J. Lonsdale, Buell T. Jannuzi, Gavin Rowell, M. Bryan, Yvonne Becherini, Aleksandar Popstefanija, M. Pohl, A. Marcowith, Jean-Pierre Ernenwein, H. Alyson Ford, Wystan Benbow, Karen E. Williamson, Daryl Haggard, Hambeleleni Ndiyavala, Tod R. Lauer, Arnaud Mares, Chaitanya Priyadarshi, Michael Punch, Helge Rottmann, J. Zorn, D. Dominis Prester, Bernd Schleicher, M. Minev, Hector Olivares, Ciriaco Goddi, S. Pita, J. Herrera, Alessia Spolon, Léa Jouvin, Na Wang, G. Martí-Devesa, Tomohiko Oka, Kirsty Feijen, E. Do Souto Espiñeira, Ralph Eatough, Johannes Veh, Stefano Gabici, Tomislav Terzić, D. Glawion, Gilles Fontaine, Bradford Benson, C. B. Rulten, Jenni Jormanainen, Jason SooHoo, Michael Titus, Jose Miguel Delgado, Marcos López-Moya, Freek Roelofs, Wlodek Bednarek, M. Lundy, Richard Anantua, Alessandra Lamastra, P. T. Reynolds, Vassil Verguilov, M. Lemoine-Goumard, G. Fichet de Clairfontaine, L. Di Venere, Michael Kreter, Jose Miguel Miranda, Alan L. Roy, Yating Chai, A. López-Oramas, M. Tluczykont, Jacek Niemiec, R. Konno, Tyler Trent, Olaf Reimer, Heino Falcke, Amanpreet Kaur, M. Panter, Narek Sahakyan, Kasper B. Schmidt, A. Carosi, K. Egberts, L. Maraschi, Stefan Cikota, V. Joshi, Koji Noda, Elisa Bernardini, Ye-Fei Yuan, Garrett K. Keating, Fumie Tazaki, Pawel Gliwny, M. Vazquez Acosta, Nicola Giglietto, M. Capasso, Vincent Piétu, Satoshi Fukami, Roman Gold, Elina Lindfors, Satoki Matsushita, A. Lemiere, F. Eichhorn, U. Katz, Yoshinori Yonekura, N. Shafi, Natalia Żywucka, Michael Kramer, M. Palatiello, Daniel Mazin, Samuel Timothy Spencer, Victoria Moreno, Oliver Porth, Julian Sitarek, Kazi L.J. Rygl, Wen Ping Lo, Geoffrey C. Bower, Ilje Cho, S. Fegan, Samuel Zouari, J. M. Paredes, V. Fallah Ramazani, Thomas Murach, Jim Hinton, R. J. White, F. Leone, S. Loporchio, M. de Naurois, Ed Fomalont, Bart Ripperda, Dominique Broguiere, J. Becerra González, Joseph R. Farah, Q. Feng, Andreas Quirrenbach, Taehyun Jung, C. Trichard, Masahiro Teshima, Domenico Tiziani, D. Malyshev, Richard Plambeck, Lynn D. Matthews, Avery E. Broderick, S. Kumar, T. J. Williamson, M. K. Daniel, Sylvia Zhu, P. J. Meintjes, Tjark Miener, Jodi Christiansen, Roger Brissenden, S. Sailer, Dmitry Khangulyan, David Paneque, Thomas P. Krichbaum, Sergey S. Savchenko, Angelo Ricarte, Riaan Steenkamp, T. Chand, J. Dyks, Francesco Dazzi, V. Baghmanyan, Zorawar Wadiasingh, Kazunori Akiyama, Stefan Ohm, C. Levy, Giovanna Ferrara, Makoto Inoue, Jhilik Majumdar, Nobuyuki Sakai, Dieter Horns, Jorge A. Preciado-López, Cornelia Müller, G. Hermann, Regis Terrier, A. J. Chromey, Dominic W. Pesce, Felix M. Pötzl, Mark Gurwell, Alejandro Cruz-Osorio, Ivan Marti-Vidal, Ben Prather, Tom Armstrong, Jongho Park, Matteo Cerruti, Ziri Younsi, Amy Furniss, Chih-Wei Locutus Huang, Lijing Shao, A. Djannati-Ataï, Shoko Koyama, D. Gottschall, P. Vincent, A. Brill, Kenji Toma, Antonios Nathanail, M. Nievas-Rosillo, M. Seglar-Arroyo, C. Delgado Mendez, Mahito Sasada, G. Busetto, Maciek Wielgus, Marcos Santander, Doosoo Yoon, D. A. Sanchez, Hiroki Okino, Christo Venter, Christiaan D. Brinkerink, James Ryan, S. Mićanović, Raquel Fraga-Encinas, Mark G. Rawlings, G. H. Sembroski, G. Principe, Xiang Liu, Karl Friedrich Schuster, Ronald Hesper, L. Sun, Ciro Bigongiari, Ramesh Narayan, M. Strzys, L. Mohrmann, Daniel R. van Rossum, Y. Ohtani, Wu Jiang, Luciano Rezzolla, Nu. Komin, V. A. Acciari, Katherine L. Bouman, Jürgen Besenrieder, Clemens Hoischen, A. A. Zdziarski, Antonio Tutone, Hung Yi Pu, A. Arbet Engels, J.-P. Lenain, A. De Angelis, Tomoya Hirota, R. J. García López, Carlo Romoli, Werner Hofmann, Tuomas Savolainen, Neil M. Nagar, Minfeng Gu, M. Karjalainen, Vitaly Neustroev, A. N. Otte, John F. C. Wardle, Tomoaki Oyama, Jongsoo Kim, Monica Barnard, J. Otero-Santos, R. D. Parsons, Pierre Christian, A. Priyana Noel, A. S. Seyffert, Shami Chatterjee, E. O. Angüner, David A. Green, Ramesh Karuppusamy, Zhiyuan Li, J. Devin, Dominik Elsaesser, F. Giordano, Santiago Ubach, Michael A. Nowak, Y. Kobayashi, F. Di Pierro, Iniyan Natarajan, A. Zech, M. Garczarczyk, Dmitriy Kostunin, Michael Janssen, Giacomo Bonnoli, Mariafelicia De Laurentis, Kuo Liu, G. Emery, Yutaro Kofuji, Antxon Alberdi, Marco Toliman Lucchini, R. A. Ong, Catherine Boisson, Daniel C. M. Palumbo, Stefan Klepser, Stefano Covino, Motoki Kino, Daniel Kerszberg, C. Armand, Maria Haupt, D. Zarić, K. Pfrang, R. López-Coto, M. Zacharias, Jae-Young Kim, Sheperd S. Doeleman, U. Barres de Almeida, Pratik Majumdar, M. V. Fonseca, Mosè Mariotti, G. Lamanna, Alexander Hahn, Sidika Merve Colak, R. J. Tuffs, B. Bi, Juan-Carlos Algaba, L. Oakes, D. Jankowsky, Y. Kajiwara, R. Marx, Bošnjak, John E. Barrett, Kotaro Niinuma, F. D'Ammando, Qingwen Wu, A. Yusafzai, Christian M. Fromm, Chi-kwan Chan, B. De Lotto, M. Kertzman, Manuela Mallamaci, H. Prokoph, Tadayuki Takahashi, Damir Lelas, Victor Doroshenko, E. Kasai, Lea Heckmann, Bong Won Sohn, Francesco Gabriele Saturni, Shiro Ikeda, T. Vuillaume, Laurent Loinard, G. Maurin, M. Füßling, Martin Will, Yi Chen, Gianluca Giavitto, Remo P. J. Tilanus, M. Spir-Jacob, Alessandro Montanari, Thomas Lohse, Tihomir Surić, J. van Scherpenberg, Per Friberg, He Sun, Luca Tosti, Kiyoaki Wajima, E. Ruiz-Velasco, Thomas Bylund, M. Balokovic, Feng Yuan, S. Nozaki, Mischa Breuhaus, Peter Galison, Y. A. Gallant, L. Olivera-Nieto, Dorota Sobczyńska, Maria-Isabel Bernardos, R. Rauth, Izumi Mizuno, Vincent L. Fish, S. G. Jorstad, Tomoki Saito, Giovanni Ceribella, Jacques Muller, J. P. Finley, Stefano Ansoldi, Boris Georgiev, Marcello Giroletti, Arturo I. Gómez-Ruiz, Karl M. Menten, Aristeidis Noutsos, P. deWilt, Junhan Kim, Alejandro Mus Mejías, Q. Remy, Dong-Jin Kim, P. G. Prada Moroni, Robert Wharton, Riccardo Paoletti, R. R. Prado, Zhi-Qiang Shen, S. Paiano, S. Chandra, Andrés Baquero, Anna Barnacka, Lucy Fortson, Wrijupan Bhattacharyya, Marc Ribó, E. de Ona Wilhelmi, Paul T. P. Ho, Yan-Rong Li, Derek Ward-Thompson, M. Scalici, G. Maneva, Constantin Steppa, Dimitrios Psaltis, A.M. Taylor, J. Damascene Mbarubucyeye, Daniel P. Marrone, Karl Mannheim, W. Boland, P. Morris, D. A. Prokhorov, M. Mohamed, Katsuaki Asano, Gernot Maier, Kotaro Moriyama, H. Odaka, M. Büchele, E. Pueschel, Kazuyoshi Nishijima, Christopher J. Duffy, H. M. Schutte, Camilla Maggio, Mark Kettenis, V. D'Elia, Saverio Lombardi, Ramprasad Rao, Ivica Puljak, R. Mirzoyan, V. Sahakian, Guang Yao Zhao, Adrian Biland, F. Werner, Rafal Moderski, Olivier Gentaz, Ullrich Schwanke, James M. Moran, S. Komossa, Yuzhu Cui, A. Jiménez-Rosales, Arash Roshanineshat, S. Ventura, Lindy Blackburn, David J. James, G. Hughes, Hidetoshi Kubo, Mansour Karami, José L. Gómez, P. Reichherzer, Davit Zargaryan, Paul Tiede, Koushik Chatterjee, Chunchong Ni, Roger Deane, Axel Donath, J. Rico, A. W. Chen, A. Fiasson, Jun Yi Koay, T. B. Humensky, Satoko Sawada-Satoh, Isak Delberth Davids, Alan P. Marscher, Alan E. E. Rogers, Rebecca Azulay, Kazuma Ishio, Paul M. Chesler, D. 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Nakashima, Alice Donini, David H. Hughes, Heinrich J. Völk, Mohanraj Senniappan, K. A. Farrell, M. Renaud, J. A. Barrio, Miriam Lucio Martinez, Rachel Simoni, P. T. O'Brien, E. Colombo, V. Barbosa Martins, M. Orienti, Efthalia Traianou, Lluis Font, B. Machado de Oliveira Fraga, Y. Suda, J. Neilsen, John Conway, Eduardo Ros, Gibwa Musoke, Tarek M. Hassan, J. Bolmont, A. Sinha, Halim Ashkar, M.-H. Grondin, Daniel Nieto, Lab Saha, Fabrizio Tavecchio, Hyunwook Ro, Michael H. Hecht, Markus Böttcher, Antonio Fuentes, Simone Mender, Moritz Hütten, Ue-Li Pen, Yosuke Mizuno, Gopal Narayanan, Lei Huang, H. Abdalla, M. A. Kastendieck, Nicola Marchili, I. Snidaric, S. Sánchez, G. Vasileiadis, Kari Nilsson, Alexander W. Raymond, Greg Lindahl, Gregory Desvignes, Sascha Trippe, Sanae Inoue, Giacomo D'Amico, W. Jin, B. van Soelen, Andrew Chael, Anne Kathrin Baczko, Shunsuke Sakurai, L. Giunti, A. Nayerhoda, Walter Alef, Jamie Holder, Stefano Truzzi, Pablo Peñil, M. J. Lang, Francois Brun, Frank M. Rieger, V. Vitale, George N. Wong, Jirong Mao, S. Caroff, J. Kushida, André Young, Ru-Sen Lu, Daniel Morcuende, Jose Luis Contreras, Kazuhiro Hada, Juan Cortina, C. van Eldik, Pablo Torne, Raymond Blundell, Jarred Gershon Green, C. B. Adams, James M. Cordes, Jonathan Weintroub, Q. Piel, A. Berti, James E. M. Watson, G. Peron, Ken Young, Garret Cotter, Dario Hrupec, Jonathan Mackey, K. Ragan, John E. Carlstrom, Michael Backes, Tim Holch, D. Hadasch, Stawarz, F. Niederwanger, Feryal Özel, Lia Medeiros, A. Weinstein, Mitsunari Takahashi, Manuel Delfino, C. Y. Kuo, Aviad Levis, Francesco Longo, K. Kosack, Konrad Bernlöhr, Jacco Vink, C. Moore, Michael Bremer, Jim Davies, Jadyn Anczarski, Patrick M. Koch, Sabrina Casanova, Ming-Tang Chen, B. Peyaud, Christian Stegmann, Stefan Wagner, C. Perennes, Yasunobu Uchiyama, David Kieda, Chet Ruszczyk, Hiroshi Nagai, M. Curyło, Andrei Lobanov, Ana Babić, E. Moulin, Tomasz Bulik, Britton Jeter, I. Vovk, Martin Makariev, C. van Rensburg, Oscar Blanch, Rocco Lico, Silke Britzen, Misao Sasaki, A. Reimer, V. Poireau, R. Adam, David Ball, Mark Reynolds, D. Miceli, John L. Quinn, Roberto Garcia, J. F. Glicenstein, D. Ribeiro, A. Wierzcholska, Geoffrey B. Crew, Bruno Khelifi, David Sánchez-Arguelles, Ilse van Bemmel, Michael D. Johnson, J. Anton Zensus, Dominik Baack, Manuel Meyer, E. V. Kravchenko, I. Jiménez, Thomas Bronzwaer, Reshmi Mukherjee, D. Berge, C. Giuri, Kleopas Shiningayamwe, Shan Shan Zhao, Yuki Iwamura, A. D. Falcone, Lenka Tomankova, Carsten Kramer, Jan Wagner, Christian Fruck, B. Rudak, Jordy Davelaar, V. Marandon, K. Katarzyński, Roberto Neri, The EHT MWL Science Working Group, Institut de RadioAstronomie Millimétrique (IRAM), Centre National de la Recherche Scientifique (CNRS), Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics (LESIA), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Instituto de RadioAstronomía Milimétrica (IRAM), Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire Univers et Théories (LUTH (UMR_8102)), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire Univers et Particules de Montpellier (LUPM), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Groupe de Physique des Solides (GPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL), Event Horizon Telescope, Fermi-LAT, H.E.S.S., MAGIC, VERITAS, EAVN, High Energy Astrophys. & Astropart. Phys (API, FNWI), API Other Research (FNWI), Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA (UMR_8109)), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Algaba, Jc, Anczarski, J, Asada, K, Balokovic, M, Chandra, S, Cui, Yz, Falcone, Ad, Giroletti, M, Goddi, C, Hada, K, Haggard, D, Jorstad, S, Kaur, A, Kawashima, T, Keating, G, Kim, Jy, Kino, M, Komossa, S, Kravchenko, Ev, Krichbaum, Tp, Lee, S, Lu, R, Lucchini, M, Markoff, S, Neilsen, J, Nowak, Ma, Park, J, Principe, G, Ramakrishnan, V, Reynolds, Mt, Sasada, M, Savchenko, S, Williamson, Ke, Longo, F, Et, Al., University of Michigan, Department of Electronics and Nanoengineering, Aalto-yliopisto, Aalto University, Algaba, J. C., Anczarski, J., Asada, K., Balokovic, M., Chandra, S., Cui, Y. -Z., Falcone, A. D., Giroletti, M., Goddi, C., Hada, K., Haggard, D., Jorstad, S., Kaur, A., Kawashima, T., Keating, G., Kim, J. -Y., Kino, M., Komossa, S., Kravchenko, E. V., Krichbaum, T. P., Lee, S. -S., Lu, R. -S., Lucchini, M., Markoff, S., Neilsen, J., Nowak, M. A., Park, J., Principe, G., Ramakrishnan, V., Reynolds, M. T., Sasada, M., Savchenko, S. S., Williamson, K. E., Akiyama, K., Alberdi, A., Alef, W., Anantua, R., Azulay, R., Baczko, A. -K., Ball, D., Barrett, J., Bintley, D., Benson, B. A., Blackburn, L., Blundell, R., Boland, W., Bouman, K. L., Bower, G. C., Boyce, H., Bremer, M., Brinkerink, C. D., Brissenden, R., Britzen, S., Broderick, A. E., Broguiere, D., Bronzwaer, T., Byun, D. -Y., Carlstrom, J. E., Chael, A., Chan, C. -K., Chatterjee, S., Chatterjee, K., Chen, M. -T., Chen, Y., Chesler, P. M., Cho, I., Christian, P., Conway, J. E., Cordes, J. M., Crawford, T. M., Crew, G. B., Cruz-Osorio, A., Davelaar, J., De Laurentis, M., Deane, R., Dempsey, J., Desvignes, G., Dexter, J., Doeleman, S. S., Eatough, R. P., Falcke, H., Farah, J., Fish, V. L., Fomalont, E., Ford, H. A., Fraga-Encinas, R., Friberg, P., Fromm, C. M., Fuentes, A., Galison, P., Gammie, C. F., Garcia, R., Gentaz, O., Georgiev, B., Gold, R., Gomez, J. L., Gomez-Ruiz, A. I., Gu, M., Gurwell, M., Hecht, M. H., Hesper, R., Ho, L. C., Ho, P., Honma, M., Huang, C. -W. L., Huang, L., Hughes, D. H., Ikeda, S., Inoue, M., Issaoun, S., James, D. J., Jannuzi, B. T., Janssen, M., Jeter, B., Jiang, W., Jimenez-Rosales, A., Johnson, M. D., Jung, T., Karami, M., Karuppusamy, R., Kettenis, M., Kim, D. -J., Kim, J., Koay, J. Y., Kofuji, Y., Koch, P. M., Koyama, S., Kramer, M., Kramer, C., Kuo, C. -Y., Lauer, T. R., Levis, A., Li, Y. -R., Li, Z., Lindqvist, M., Lico, R., Lindahl, G., Liu, J., Liu, K., Liuzzo, E., Lo, W. -P., Lobanov, A. P., Loinard, L., Lonsdale, C., Macdonald, N. R., Mao, J., Marchili, N., Marrone, D. P., Marscher, A. P., Marti-Vidal, I., Matsushita, S., Matthews, L. D., Medeiros, L., Menten, K. M., Mizuno, I., Mizuno, Y., Moran, J. M., Moriyama, K., Moscibrodzka, M., Muller, C., Musoke, G., Mejias, A. M., Nagai, H., Nagar, N. M., Nakamura, M., Narayan, R., Narayanan, G., Natarajan, I., Nathanail, A., Neri, R., Ni, C., Noutsos, A., Okino, H., Olivares, H., Ortiz-Leon, G. N., Oyama, T., Ozel, F., Palumbo, D. C. M., Patel, N., Pen, U. -L., Pesce, D. W., Pietu, V., Plambeck, R., Popstefanija, A., Porth, O., Potzl, F. M., Prather, B., Preciado-Lopez, J. A., Psaltis, D., Pu, H. -Y., Rao, R., Rawlings, M. G., Raymond, A. W., Rezzolla, L., Ricarte, A., Ripperda, B., Roelofs, F., Rogers, A., Ros, E., Rose, M., Roshanineshat, A., Rottmann, H., Roy, A. L., Ruszczyk, C., Rygl, K. L. J., Sanchez, S., Sanchez-Arguelles, D., Savolainen, T., Schloerb, F. P., Schuster, K. -F., Shao, L., Shen, Z., Small, D., Sohn, B. W., Soohoo, J., Sun, H., Tazaki, F., Tetarenko, A. J., Tiede, P., Tilanus, R. P. J., Titus, M., Toma, K., Torne, P., Trent, T., Traianou, E., Trippe, S., Van Bemmel, I., Van Langevelde, H. J., Van Rossum, D. R., Wagner, J., Ward-Thompson, D., Wardle, J., Weintroub, J., Wex, N., Wharton, R., Wielgus, M., Wong, G. N., Wu, Q., Yoon, D., Young, A., Young, K., Younsi, Z., Yuan, F., Yuan, Y. -F., Zensus, J. A., Zhao, G. -Y., Zhao, S. -S., D'Ammando, F., Orienti, M., Abdalla, H., Adam, R., Aharonian, F., Benkhali, F. A., Anguner, E. O., Arcaro, C., Armand, C., Armstrong, T., Ashkar, H., Backes, M., Baghmanyan, V., Barbosa Martins, V., Barnacka, A., Barnard, M., Becherini, Y., Berge, D., Bernlohr, K., Bi, B., Bottcher, M., Boisson, C., Bolmont, J., De Bony De Lavergne, M., Breuhaus, M., Brun, F., Brun, P., Bryan, M., Buchele, M., Bulik, T., Bylund, T., Caroff, S., Carosi, A., Casanova, S., Chand, T., Chen, A., Cotter, G., Curylo, M., Damascene Mbarubucyeye, J., Davids, I. D., Davies, J., Deil, C., Devin, J., Dewilt, P., Dirson, L., Djannati-Atai, A., Dmytriiev, A., Donath, A., Doroshenko, V., Duffy, C., Dyks, J., Egberts, K., Eichhorn, F., Einecke, S., Emery, G., Ernenwein, J. -P., Feijen, K., Fegan, S., Fiasson, A., De Clairfontaine, G. F., Fontaine, G., Funk, S., Fussling, M., Gabici, S., Gallant, Y. A., Giavitto, G., Giunti, L., Glawion, D., Glicenstein, J. F., Gottschall, D., Grondin, M. -H., Hahn, J., Haupt, M., Hermann, G., Hinton, J. A., Hofmann, W., Hoischen, C., Holch, T. L., Holler, M., Horbe, M., Horns, D., Huber, D., Jamrozy, M., Jankowsky, D., Jankowsky, F., Jardin-Blicq, A., Joshi, V., Jung-Richardt, I., Kasai, E., Kastendieck, M. A., Katarzynski, K., Katz, U., Khangulyan, D., Khelifi, B., Klepser, S., Kluzniak, W., Komin, N., Konno, R., Kosack, K., Kostunin, D., Kreter, M., Lamanna, G., Lemiere, A., Lemoine-Goumard, M., Lenain, J. -P., Levy, C., Lohse, T., Lypova, I., Mackey, J., Majumdar, J., Malyshev, D., Marandon, V., Marchegiani, P., Marcowith, A., Mares, A., Marti-Devesa, G., Marx, R., Maurin, G., Meintjes, P. J., Meyer, M., Moderski, R., Mohamed, M., Mohrmann, L., Montanari, A., Moore, C., Morris, P., Moulin, E., Muller, J., Murach, T., Nakashima, K., Nayerhoda, A., De Naurois, M., Ndiyavala, H., Niederwanger, F., Niemiec, J., Oakes, L., O'Brien, P., Odaka, H., Ohm, S., Olivera-Nieto, L., De Ona Wilhelmi, E., Ostrowski, M., Panter, M., Panny, S., Parsons, R. D., Peron, G., Peyaud, B., Piel, Q., Pita, S., Poireau, V., Noel, A. P., Prokhorov, D. A., Prokoph, H., Puhlhofer, G., Punch, M., Quirrenbach, A., Rauth, R., Reichherzer, P., Reimer, A., Reimer, O., Remy, Q., Renaud, M., Rieger, F., Rinchiuso, L., Romoli, C., Rowell, G., Rudak, B., Ruiz-Velasco, E., Sahakian, V., Sailer, S., Sanchez, D. A., Santangelo, A., Sasaki, M., Scalici, M., Schutte, H. M., Schwanke, U., Schwemmer, S., Seglar-Arroyo, M., Senniappan, M., Seyffert, A. S., Shafi, N., Shiningayamwe, K., Simoni, R., Sinha, A., Sol, H., Specovius, A., Spencer, S., Spir-Jacob, M., Stawarz, L., Sun, L., Steenkamp, R., Stegmann, C., Steinmassl, S., Steppa, C., Takahashi, T., Tavernier, T., Taylor, A. M., Terrier, R., Tiziani, D., Tluczykont, M., Tomankova, L., Trichard, C., Tsirou, M., Tuffs, R., Uchiyama, Y., Van Der Walt, D. J., Van Eldik, C., Van Rensburg, C., Van Soelen, B., Vasileiadis, G., Veh, J., Venter, C., Vincent, P., Vink, J., Volk, H. J., Vuillaume, T., Wadiasingh, Z., Wagner, S. J., Watson, J., Werner, F., White, R., Wierzcholska, A., Wong, Y. W., Yusafzai, A., Zacharias, M., Zanin, R., Zargaryan, D., Zdziarski, A. A., Zech, A., Zhu, S. J., Zorn, J., Zouari, S., Zywucka, N., Acciari, V. A., Ansoldi, S., Antonelli, L. A., Engels, A. A., Artero, M., Asano, K., Baack, D., Babic, A., Baquero, A., De Almeida, U. B., Barrio, J. A., Becerra Gonzalez, J., Bednarek, W., Bellizzi, L., Bernardini, E., Bernardos, M., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bonnoli, G., Bosnjak, Z., Busetto, G., Carosi, R., Ceribella, G., Cerruti, M., Chai, Y., Chilingarian, A., Cikota, S., Colak, S. M., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D'Amico, G., D'Elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Delfino, M., Delgado, J., Delgado Mendez, C., Depaoli, D., Di Pierro, F., Di Venere, L., Do Souto Espineira, E., Dominis Prester, D., Donini, A., Dorner, D., Doro, M., Elsaesser, D., Fallah Ramazani, V., Fattorini, A., Ferrara, G., Fonseca, M. V., Font, L., Fruck, C., Fukami, S., Garcia Lopez, R. J., Garczarczyk, M., Gasparyan, S., Gaug, M., Giglietto, N., Giordano, F., Gliwny, P., Godinovic, N., Green, J. G., Green, D., Hadasch, D., Hahn, A., Heckmann, L., Herrera, J., Hoang, J., Hrupec, D., Hutten, M., Inada, T., Inoue, S., Ishio, K., Iwamura, Y., Jimenez, I., Jormanainen, J., Jouvin, L., Kajiwara, Y., Karjalainen, M., Kerszberg, D., Kobayashi, Y., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Lombardi, S., Longo, F., Lopez-Coto, R., Lopez-Moya, M., Lopez-Oramas, A., Loporchio, S., Machado De Oliveira Fraga, B., Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martinez, M., Mazin, D., Menchiari, S., Mender, S., Micanovic, S., Miceli, D., Miener, T., Minev, M., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Morcuende, D., Moreno, V., Moretti, E., Neustroev, V., Nigro, C., Nilsson, K., Nishijima, K., Noda, K., Nozaki, S., Ohtani, Y., Oka, T., Otero-Santos, J., Paiano, S., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Pavletic, L., Penil, P., Perennes, C., Persic, M., Moroni, P. G. P., Prandini, E., Priyadarshi, C., Puljak, I., Rhode, W., Ribo, M., Rico, J., Righi, C., Rugliancich, A., Saha, L., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Saturni, F. G., Schleicher, B., Schmidt, K., Schweizer, T., Sitarek, J., Snidaric, I., Sobczynska, D., Spolon, A., Stamerra, A., Strom, D., Strzys, M., Suda, Y., Suric, T., Takahashi, M., Tavecchio, F., Temnikov, P., Terzic, T., Teshima, M., Tosti, L., Truzzi, S., Tutone, A., Ubach, S., Van Scherpenberg, J., Vanzo, G., Vazquez Acosta, M., Ventura, S., Verguilov, V., Vigorito, C. F., Vitale, V., Vovk, I., Will, M., Wunderlich, C., Zaric, D., Adams, C. B., Benbow, W., Brill, A., Capasso, M., Christiansen, J. L., Chromey, A. J., Daniel, M. K., Errando, M., Farrell, K. A., Feng, Q., Finley, J. P., Fortson, L., Furniss, A., Gent, A., Giuri, C., Hassan, T., Hervet, O., Holder, J., Hughes, G., Humensky, T. B., Jin, W., Kaaret, P., Kertzman, M., Kieda, D., Kumar, S., Lang, M. J., Lundy, M., Maier, G., Moriarty, P., Mukherjee, R., Nieto, D., Nievas-Rosillo, M., O'Brien, S., Ong, R. A., Otte, A. N., Patel, S., Pfrang, K., Pohl, M., Prado, R. R., Pueschel, E., Quinn, J., Ragan, K., Reynolds, P. T., Ribeiro, D., Richards, G. T., Roache, E., Rulten, C., Ryan, J. L., Santander, M., Sembroski, G. H., Shang, R., Weinstein, A., Williams, D. A., Williamson, T. J., Hirota, T., Cui, L., Niinuma, K., Ro, H., Sakai, N., Sawada-Satoh, S., Wajima, K., Wang, N., Liu, X., Yonekura, Y., German Research Foundation, Istituto Nazionale di Fisica Nucleare, Swiss National Science Foundation, Ministerio de Ciencia, Innovación y Universidades (España), Department of Atomic Energy (India), University of Tokyo, Japan Society for the Promotion of Science, Ministry of Education and Scientific Research (Romania), Academy of Finland, La Caixa, Croatian Science Foundation, Generalitat de Catalunya, Polish National Agency for Academic Exchange, University of Rijeka, Department of Energy (US), Smithsonian Institution, Astronomy, and Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Montpellier 2 - Sciences et Techniques (UM2)
Subjects: Accretion, 010504 meteorology & atmospheric sciences, Astronomy, Flux, Astrophysics, 7. Clean energy, 01 natural sciences, Active galactic nuclei, Radio cores, Low-luminosity active galactic nuclei, High energy astrophysics, Astrophysical black holes, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Astrophysics of Galaxies, 010303 astronomy & astrophysics, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, astro-ph.HE, Radio core, Accretion (meteorology), 520 Astronomie und zugeordnete Wissenschaften, Low-luminosity, active galactic nuclei, Astrophysical black hole, astro-ph.CO, Cosmology and Nongalactic Astrophysics (astro-ph.CO), Active galactic nucleus, High-energy astronomy, astro-ph.GA, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, F500, Astrophysics::Cosmology and Extragalactic Astrophysics, High energy astrophysic, 0103 physical sciences, Very-long-baseline interferometry, ddc:530, Astrophysics::Galaxy Astrophysics, 0105 earth and related environmental sciences, Event Horizon Telescope, Supermassive black hole, Astronomy and Astrophysics, 530 Physik, Galaxy, Space and Planetary Science, Astrophysics of Galaxies (astro-ph.GA), ddc:520, HESS - Abteilung Hinton, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract: Full list of authors: EHT MWL Science Working Group; Algaba, J. C.; Anczarski, J.; Asada, K.; Baloković, M.; Chandra, S.; Cui, Y. -Z.; Falcone, A. D.; Giroletti, M.; Goddi, C.; Hada, K.; Haggard, D.; Jorstad, S.; Kaur, A.; Kawashima, T.; Keating, G.; Kim, J. -Y.; Kino, M.; Komossa, S.; Kravchenko, E. V.; Krichbaum, T. P.; Lee, S. -S.; Lu, R. -S.; Lucchini, M.; Markoff, S.; Neilsen, J.; Nowak, M. A.; Park, J.; Principe, G.; Ramakrishnan, V.; Reynolds, M. T.; Sasada, M.; Savchenko, S. S.; Williamson, K. E.; Event Horizon Telescope Collaboration; Akiyama, Kazunori; Alberdi, Antxon; Alef, Walter; Anantua, Richard; Azulay, Rebecca; Baczko, Anne-Kathrin; Ball, David; Barrett, John; Bintley, Dan; Benson, Bradford A.; Blackburn, Lindy; Blundell, Raymond; Boland, Wilfred; Bouman, Katherine L.; Bower, Geoffrey C.; Boyce, Hope; Bremer, Michael; Brinkerink, Christiaan D.; Brissenden, Roger; Britzen, Silke; Broderick, Avery E.; Broguiere, Dominique; Bronzwaer, Thomas; Byun, Do-Young; Carlstrom, John E.; Chael, Andrew; Chan, Chi-Kwan; Chatterjee, Shami; Chatterjee, Koushik; Chen, Ming-Tang; Chen, Yongjun; Chesler, Paul M.; Cho, Ilje; Christian, Pierre; Conway, John E.; Cordes, James M.; Crawford, Thomas M.; Crew, Geoffrey B.; Cruz-Osorio, Alejandro; Davelaar, Jordy; de Laurentis, Mariafelicia; Deane, Roger; Dempsey, Jessica; Desvignes, Gregory; Dexter, Jason; Doeleman, Sheperd S.; Eatough, Ralph P.; Falcke, Heino; Farah, Joseph; Fish, Vincent L.; Fomalont, Ed; Ford, H. Alyson; Fraga-Encinas, Raquel; Friberg, Per; Fromm, Christian M.; Fuentes, Antonio; Galison, Peter; Gammie, Charles F.; García, Roberto; Gentaz, Olivier; Georgiev, Boris; Gold, Roman; Gómez, José L.; Gómez-Ruiz, Arturo I.; Gu, Minfeng; Gurwell, Mark; Hecht, Michael H.; Hesper, Ronald; Ho, Luis C.; Ho, Paul; Honma, Mareki; Huang, Chih-Wei L.; Huang, Lei; Hughes, David H.; Ikeda, Shiro; Inoue, Makoto; Issaoun, Sara; James, David J.; Jannuzi, Buell T.; Janssen, Michael; Jeter, Britton; Jiang, Wu; Jiménez-Rosales, Alejandra; Johnson, Michael D.; Jung, Taehyun; Karami, Mansour; Karuppusamy, Ramesh; Kettenis, Mark; Kim, Dong-Jin; Kim, Jongsoo; Kim, Junhan; Koay, Jun Yi; Kofuji, Yutaro; Koch, Patrick M.; Koyama, Shoko; Kramer, Michael; Kramer, Carsten; Kuo, Cheng-Yu; Lauer, Tod R.; Levis, Aviad; Li, Yan-Rong; Li, Zhiyuan; Lindqvist, Michael; Lico, Rocco; Lindahl, Greg; Liu, Jun; Liu, Kuo; Liuzzo, Elisabetta; Lo, Wen-Ping; Lobanov, Andrei P.; Loinard, Laurent; Lonsdale, Colin; MacDonald, Nicholas R.; Mao, Jirong; Marchili, Nicola; Marrone, Daniel P.; Marscher, Alan P.; Martí-Vidal, Iván; Matsushita, Satoki; Matthews, Lynn D.; Medeiros, Lia; Menten, Karl M.; Mizuno, Izumi; Mizuno, Yosuke; Moran, James M.; Moriyama, Kotaro; Moscibrodzka, Monika; Müller, Cornelia; Musoke, Gibwa; Mejías, Alejandro Mus; Nagai, Hiroshi; Nagar, Neil M.; Nakamura, Masanori; Narayan, Ramesh; Narayanan, Gopal; Natarajan, Iniyan; Nathanail, Antonios; Neri, Roberto; Ni, Chunchong; Noutsos, Aristeidis; Okino, Hiroki; Olivares, Héctor; Ortiz-León, Gisela N.; Oyama, Tomoaki; Özel, Feryal; Palumbo, Daniel C. M.; Patel, Nimesh; Pen, Ue-Li; Pesce, Dominic W.; Piétu, Vincent; Plambeck, Richard; Popstefanija, Aleksandar; Porth, Oliver; Pötzl, Felix M.; Prather, Ben; Preciado-López, Jorge A.; Psaltis, Dimitrios; Pu, Hung-Yi; Rao, Ramprasad; Rawlings, Mark G.; Raymond, Alexander W.; Rezzolla, Luciano; Ricarte, Angelo; Ripperda, Bart; Roelofs, Freek; Rogers, Alan; Ros, Eduardo; Rose, Mel; Roshanineshat, Arash; Rottmann, Helge; Roy, Alan L.; Ruszczyk, Chet; Rygl, Kazi L. J.; Sánchez, Salvador; Sánchez-Arguelles, David; Savolainen, Tuomas; Schloerb, F. Peter; Schuster, Karl-Friedrich; Shao, Lijing; Shen, Zhiqiang; Small, Des; Sohn, Bong Won; Soohoo, Jason; Sun, He; Tazaki, Fumie; Tetarenko, Alexandra J.; Tiede, Paul; Tilanus, Remo P. J.; Titus, Michael; Toma, Kenji; Torne, Pablo; Trent, Tyler; Traianou, Efthalia; Trippe, Sascha; van Bemmel, Ilse; van Langevelde, Huib Jan; van Rossum, Daniel R.; Wagner, Jan; Ward-Thompson, Derek; Wardle, John; Weintroub, Jonathan; Wex, Norbert; Wharton, Robert; Wielgus, Maciek; Wong, George N.; Wu, Qingwen; Yoon, Doosoo; Young, André; Young, Ken; Younsi, Ziri; Yuan, Feng; Yuan, Ye-Fei; Zensus, J. Anton; Zhao, Guang-Yao; Zhao, Shan-Shan; Fermi Large Area Telescope Collaboration; Principe, G.; Giroletti, M.; D'Ammando, F.; Orienti, M.; H. E. S. S. Collaboration; Abdalla, H.; Adam, R.; Aharonian, F.; Benkhali, F. Ait; Angüner, E. O.; Arcaro, C.; Armand, C.; Armstrong, T.; Ashkar, H.; Backes, M.; Baghmanyan, V.; Barbosa Martins, V.; Barnacka, A.; Barnard, M.; Becherini, Y.; Berge, D.; Bernlöhr, K.; Bi, B.; Böttcher, M.; Boisson, C.; Bolmont, J.; de Lavergne, M. De Bony; Breuhaus, M.; Brun, F.; Brun, P.; Bryan, M.; Büchele, M.; Bulik, T.; Bylund, T.; Caroff, S.; Carosi, A.; Casanova, S.; Chand, T.; Chen, A.; Cotter, G.; Curyło, M.; Damascene Mbarubucyeye, J.; Davids, I. D.; Davies, J.; Deil, C.; Devin, J.; Dewilt, P.; Dirson, L.; Djannati-Ataï, A.; Dmytriiev, A.; Donath, A.; Doroshenko, V.; Duffy, C.; Dyks, J.; Egberts, K.; Eichhorn, F.; Einecke, S.; Emery, G.; Ernenwein, J. -P.; Feijen, K.; Fegan, S.; Fiasson, A.; de Clairfontaine, G. Fichet; Fontaine, G.; Funk, S.; Füßling, M.; Gabici, S.; Gallant, Y. A.; Giavitto, G.; Giunti, L.; Glawion, D.; Glicenstein, J. F.; Gottschall, D.; Grondin, M. -H.; Hahn, J.; Haupt, M.; Hermann, G.; Hinton, J. A.; Hofmann, W.; Hoischen, C.; Holch, T. L.; Holler, M.; Hörbe, M.; Horns, D.; Huber, D.; Jamrozy, M.; Jankowsky, D.; Jankowsky, F.; Jardin-Blicq, A.; Joshi, V.; Jung-Richardt, I.; Kasai, E.; Kastendieck, M. A.; Katarzyński, K.; Katz, U.; Khangulyan, D.; Khélifi, B.; Klepser, S.; Kluźniak, W.; Komin, Nu.; Konno, R.; Kosack, K.; Kostunin, D.; Kreter, M.; Lamanna, G.; Lemière, A.; Lemoine-Goumard, M.; Lenain, J. -P.; Levy, C.; Lohse, T.; Lypova, I.; Mackey, J.; Majumdar, J.; Malyshev, D.; Malyshev, D.; Marandon, V.; Marchegiani, P.; Marcowith, A.; Mares, A.; Martí-Devesa, G.; Marx, R.; Maurin, G.; Meintjes, P. J.; Meyer, M.; Moderski, R.; Mohamed, M.; Mohrmann, L.; Montanari, A.; Moore, C.; Morris, P.; Moulin, E.; Muller, J.; Murach, T.; Nakashima, K.; Nayerhoda, A.; de Naurois, M.; Ndiyavala, H.; Niederwanger, F.; Niemiec, J.; Oakes, L.; O'Brien, P.; Odaka, H.; Ohm, S.; Olivera-Nieto, L.; de Ona Wilhelmi, E.; Ostrowski, M.; Panter, M.; Panny, S.; Parsons, R. D.; Peron, G.; Peyaud, B.; Piel, Q.; Pita, S.; Poireau, V.; Noel, A. Priyana; Prokhorov, D. A.; Prokoph, H.; Pühlhofer, G.; Punch, M.; Quirrenbach, A.; Rauth, R.; Reichherzer, P.; Reimer, A.; Reimer, O.; Remy, Q.; Renaud, M.; Rieger, F.; Rinchiuso, L.; Romoli, C.; Rowell, G.; Rudak, B.; Ruiz-Velasco, E.; Sahakian, V.; Sailer, S.; Sanchez, D. A.; Santangelo, A.; Sasaki, M.; Scalici, M.; Schutte, H. M.; Schwanke, U.; Schwemmer, S.; Seglar-Arroyo, M.; Senniappan, M.; Seyffert, A. S.; Shafi, N.; Shiningayamwe, K.; Simoni, R.; Sinha, A.; Sol, H.; Specovius, A.; Spencer, S.; Spir-Jacob, M.; Stawarz, Ł.; Sun, L.; Steenkamp, R.; Stegmann, C.; Steinmassl, S.; Steppa, C.; Takahashi, T.; Tavernier, T.; Taylor, A. M.; Terrier, R.; Tiziani, D.; Tluczykont, M.; Tomankova, L.; Trichard, C.; Tsirou, M.; Tuffs, R.; Uchiyama, Y.; van der Walt, D. J.; van Eldik, C.; van Rensburg, C.; van Soelen, B.; Vasileiadis, G.; Veh, J.; Venter, C.; Vincent, P.; Vink, J.; Völk, H. J.; Vuillaume, T.; Wadiasingh, Z.; Wagner, S. J.; Watson, J.; Werner, F.; White, R.; Wierzcholska, A.; Wong, Yu Wun; Yusafzai, A.; Zacharias, M.; Zanin, R.; Zargaryan, D.; Zdziarski, A. A.; Zech, A.; Zhu, S. J.; Zorn, J.; Zouari, S.; Żywucka, N.; MAGIC Collaboration; Acciari, V. A.; Ansoldi, S.; Antonelli, L. A.; Engels, A. Arbet; Artero, M.; Asano, K.; Baack, D.; Babić, A.; Baquero, A.; de Almeida, U. Barres; Barrio, J. A.; Becerra González, J.; Bednarek, W.; Bellizzi, L.; Bernardini, E.; Bernardos, M.; Berti, A.; Besenrieder, J.; Bhattacharyya, W.; Bigongiari, C.; Biland, A.; Blanch, O.; Bonnoli, G.; Bošnjak, Ž.; Busetto, G.; Carosi, R.; Ceribella, G.; Cerruti, M.; Chai, Y.; Chilingarian, A.; Cikota, S.; Colak, S. M.; Colombo, E.; Contreras, J. L.; Cortina, J.; Covino, S.; D'Amico, G.; D'Elia, V.; da Vela, P.; Dazzi, F.; de Angelis, A.; de Lotto, B.; Delfino, M.; Delgado, J.; Delgado Mendez, C.; Depaoli, D.; di Pierro, F.; di Venere, L.; Do Souto Espiñeira, E.; Dominis Prester, D.; Donini, A.; Dorner, D.; Doro, M.; Elsaesser, D.; Ramazani, V. Fallah; Fattorini, A.; Ferrara, G.; Fonseca, M. V.; Font, L.; Fruck, C.; Fukami, S.; García López, R. J.; Garczarczyk, M.; Gasparyan, S.; Gaug, M.; Giglietto, N.; Giordano, F.; Gliwny, P.; Godinović, N.; Green, J. G.; Green, D.; Hadasch, D.; Hahn, A.; Heckmann, L.; Herrera, J.; Hoang, J.; Hrupec, D.; Hütten, M.; Inada, T.; Inoue, S.; Ishio, K.; Iwamura, Y.; Jiménez, I.; Jormanainen, J.; Jouvin, L.; Kajiwara, Y.; Karjalainen, M.; Kerszberg, D.; Kobayashi, Y.; Kubo, H.; Kushida, J.; Lamastra, A.; Lelas, D.; Leone, F.; Lindfors, E.; Lombardi, S.; Longo, F.; López-Coto, R.; López-Moya, M.; López-Oramas, A.; Loporchio, S.; Machado de Oliveira Fraga, B.; Maggio, C.; Majumdar, P.; Makariev, M.; Mallamaci, M.; Maneva, G.; Manganaro, M.; Mannheim, K.; Maraschi, L.; Mariotti, M.; Martínez, M.; Mazin, D.; Menchiari, S.; Mender, S.; Mićanović, S.; Miceli, D.; Miener, T.; Minev, M.; Miranda, J. M.; Mirzoyan, R.; Molina, E.; Moralejo, A.; Morcuende, D.; Moreno, V.; Moretti, E.; Neustroev, V.; Nigro, C.; Nilsson, K.; Nishijima, K.; Noda, K.; Nozaki, S.; Ohtani, Y.; Oka, T.; Otero-Santos, J.; Paiano, S.; Palatiello, M.; Paneque, D.; Paoletti, R.; Paredes, J. M.; Pavletić, L.; Peñil, P.; Perennes, C.; Persic, M.; Moroni, P. G. Prada; Prandini, E.; Priyadarshi, C.; Puljak, I.; Rhode, W.; Ribó, M.; Rico, J.; Righi, C.; Rugliancich, A.; Saha, L.; Sahakyan, N.; Saito, T.; Sakurai, S.; Satalecka, K.; Saturni, F. G.; Schleicher, B.; Schmidt, K.; Schweizer, T.; Sitarek, J.; Šnidarić, I.; Sobczynska, D.; Spolon, A.; Stamerra, A.; Strom, D.; Strzys, M.; Suda, Y.; Surić, T.; Takahashi, M.; Tavecchio, F.; Temnikov, P.; Terzić, T.; Teshima, M.; Tosti, L.; Truzzi, S.; Tutone, A.; Ubach, S.; van Scherpenberg, J.; Vanzo, G.; Vazquez Acosta, M.; Ventura, S.; Verguilov, V.; Vigorito, C. F.; Vitale, V.; Vovk, I.; Will, M.; Wunderlich, C.; Zarić, D.; VERITAS Collaboration; Adams, C. B.; Benbow, W.; Brill, A.; Capasso, M.; Christiansen, J. L.; Chromey, A. J.; Daniel, M. K.; Errando, M.; Farrell, K. A.; Feng, Q.; Finley, J. P.; Fortson, L.; Furniss, A.; Gent, A.; Giuri, C.; Hassan, T.; Hervet, O.; Holder, J.; Hughes, G.; Humensky, T. B.; Jin, W.; Kaaret, P.; Kertzman, M.; Kieda, D.; Kumar, S.; Lang, M. J.; Lundy, M.; Maier, G.; Moriarty, P.; Mukherjee, R.; Nieto, D.; Nievas-Rosillo, M.; O'Brien, S.; Ong, R. A.; Otte, A. N.; Patel, S.; Pfrang, K.; Pohl, M.; Prado, R. R.; Pueschel, E.; Quinn, J.; Ragan, K.; Reynolds, P. T.; Ribeiro, D.; Richards, G. T.; Roache, E.; Rulten, C.; Ryan, J. L.; Santander, M.; Sembroski, G. H.; Shang, R.; Weinstein, A.; Williams, D. A.; Williamson, T. J.; Eavn Collaboration; Hirota, Tomoya; Cui, Lang; Niinuma, Kotaro; Ro, Hyunwook; Sakai, Nobuyuki; Sawada-Satoh, Satoko; Wajima, Kiyoaki; Wang, Na; Liu, Xiang; Yonekura, Yoshinori, In 2017, the Event Horizon Telescope (EHT) Collaboration succeeded in capturing the first direct image of the center of the M87 galaxy. The asymmetric ring morphology and size are consistent with theoretical expectations for a weakly accreting supermassive black hole of mass ∼6.5 × 109 M o˙. The EHTC also partnered with several international facilities in space and on the ground, to arrange an extensive, quasi-simultaneous multi-wavelength campaign. This Letter presents the results and analysis of this campaign, as well as the multi-wavelength data as a legacy data repository. We captured M87 in a historically low state, and the core flux dominates over HST-1 at high energies, making it possible to combine core flux constraints with the more spatially precise very long baseline interferometry data. We present the most complete simultaneous multi-wavelength spectrum of the active nucleus to date, and discuss the complexity and caveats of combining data from different spatial scales into one broadband spectrum. We apply two heuristic, isotropic leptonic single-zone models to provide insight into the basic source properties, but conclude that a structured jet is necessary to explain M87's spectrum. We can exclude that the simultaneous γ-ray emission is produced via inverse Compton emission in the same region producing the EHT mm-band emission, and further conclude that the γ-rays can only be produced in the inner jets (inward of HST-1) if there are strongly particle-dominated regions. Direct synchrotron emission from accelerated protons and secondaries cannot yet be excluded., The financial support of the German BMBF, MPG and HGF; the Italian INFN and INAF; the Swiss National Fund SNF; the ERDF under the Spanish Ministerio de Ciencia e Innovacion (MICINN) (FPA2017-87859-P, FPA2017-85668-P, FPA2017- 82729-C6-5-R, FPA2017-90566-REDC, PID2019-104114RBC31, PID2019-104114RB-C32, PID2019-105510GB-C31,PID 2019-107847RB-C41, PID2019-107847RB-C42, PID2019- 107988GB-C22); the Indian Department of Atomic Energy; the Japanese ICRR, the University of Tokyo, JSPS, and MEXT; the Bulgarian Ministry of Education and Science, National RI Roadmap Project DO1-268/16.12.2019 and the Academy of Finland grant No. 320045 is gratefully acknowledged. This work was also supported by the Spanish Centro de Excelencia “Severo Ochoa” SEV-2016-0588 and CEX2019- 000920-S, and “Maria de Maeztu” CEX2019-000918-M, the Unidad de Excelencia “Maria de Maeztu” MDM-2015-0509- 18-2 and the “la Caixa” Foundation (fellowship LCF/BQ/ PI18/11630012) and by the CERCA program of the Generalitat de Catalunya; by the Croatian Science Foundation (HrZZ) Project IP-2016-06-9782 and the University of Rijeka Project 13.12.1.3.02; by the DFG Collaborative Research Centers SFB823/C4 and SFB876/C3; the Polish National Research Centre grant UMO-2016/22/M/ST9/00382; and by the Brazilian MCTIC, CNPq, and FAPERJ. This research is supported by grants from the U.S. Department of Energy Office of Science, the U.S. National Science Foundation and the Smithsonian Institution, by NSERC in Canada, and by the Helmholtz Association in Germany. This research used resources provided by the Open Science Grid, which is supported by the National Science Foundation and the U.S. Department of Energy’s Office of Science, and resources of the National Energy Research Scientific Computing Center (NERSC), a U.S. Department of Energy Office of Science User Facility operated under Contract No. DE-AC02-05CH11231. We acknowledge the excellent work of the technical support staff at the Fred Lawrence Whipple Observatory and at the collaborating institutions in the construction and operation of the instrument.
Published: 2021

36. Gold Coated Nanoparticles Functionalized by Photochemical Immobilization Technique for Immunosensing

Author: Raffaele Campanile, Raffaele Velotta, A. Forente, Martina Cimafonte, Emanuela Scardapane, Antonio Minopoli, B. Della Ventura, V. Elia, Chiara Schiattarella, Della Ventura, B., Campanile, R., Cimafonte, M., Elia, V., Forente, A., Minopoli, A., Scardapane, E., Schiattarella, C., and Velotta, R.
Subjects: Localised surface plasmon resonance, Materials science, Colorimetric, 010401 analytical chemistry, Nanoparticle, 02 engineering and technology, 021001 nanoscience & nanotechnology, Photochemistry, 01 natural sciences, 0104 chemical sciences, Photochemical immobilization technique, Colloidal gold, Optical transducers, Magnetic nanoparticles, Surface modification, Gold surface, Core-shell nanoparticle, 0210 nano-technology, Biosensor, Plasmon
Abstract: Gold nanoparticles (AuNP)s play a fundamental role in biosensing in view of their various applications, each of them exploiting one or more properties of such a system. In any case, to make AuNPs effective as biosensing tools, it is necessary to provide them with high specificity by means of processes able to achieve an efficient gold surface functionalization with antibodies. This issue can be easily addressed by the so-called Photochemical Immobilization Technique (PIT). Herein, we report PIT-functionalized AuNPs applied as ballast for improving the sensitivity of quartz-crystal microbalances, but also as optical transducers (colorimetric biosensor) in which the key role is played by the plasmonic properties of nanostructured gold. Eventually, the role of gold is highlighted in its combination with magnetic nanoparticles, a physical system in which the magnetic behaviour of the core is joined to the optical properties of the surface.
Published: 2021

37. VLT/X-SHOOTER ABSORPTION SPECTROSCOPY OF THE GRB 120327A AFTERGLOW

Author: V. D’Elia
Published: 2020

38. Observational constraints on the optical and near-infrared emission from the neutron star-black hole binary merger S190814bv

Author: F. D'Ammando, Mattia Bulla, A. Fiore, P. T. O'Brien, Patricia Schady, T. Heikkilä, Matt Nicholl, Giorgos Leloudas, K. C. Chambers, Luciano Nicastro, Riccardo Ciolfi, Michela Mapelli, Armin Rest, R. Cutter, Tassilo Schweyer, J. Gillanders, G. De Cesare, Lorenzo Amati, L. Nuttal, Lána Salmon, Nancy Elias-Rosa, O. McBrien, A. Grado, David Alexander Kann, Ruben Salvaterra, P. D'Avanzo, M. T. Botticella, Johan P. U. Fynbo, M. G. Bernardini, Francesco Longo, Danny Steeghs, S. X. Yi, Peter G. Jonker, Eliana Palazzi, Y. D. Hu, Zhi-Ping Jin, Seppo Mattila, A. Gomboc, G. Ghirlanda, Alexis Coleiro, Sylvain Chaty, S. Yang, Elizabeth R. Stanway, D. R. Young, Rubina Kotak, Luca Izzo, Franz E. Bauer, Massimo Turatto, Christa Gall, A. Melandri, Eric Thrane, S. R. Oates, Francesca Onori, S. Srivastav, M. Branchesi, Michael S. Smith, Christopher W. Stubbs, Vincenzo Testa, Anders Jerkstrand, J. Japelj, Carlos González-Fernández, Elena Pian, Lluís Galbany, Luca Sbordone, Enrico Cappellaro, A. Possenti, Paul J. Groot, S. Rosetti, L. Denneau, Mark Kennedy, Jesper Sollerman, Klaas Wiersema, Chris M. Copperwheat, Cosimo Inserra, Kasper E. Heintz, E. C. Kool, M. de Pasquale, G. Greco, Krzysztof Ulaczyk, Daniel A. Perley, Om Sharan Salafia, Eugene A. Magnier, T. M. Reynolds, Andrew J. Levan, A. J. van der Horst, G. Stratta, B. Milvang-Jensen, Erkki Kankare, Darach Watson, B. Patricelli, N. B. Sabha, T. W. Chen, Kendall Ackley, Maria Letizia Pumo, Nial R. Tanvir, P. A. Evans, Michał J. Michałowski, S. Klose, R. L. C. Starling, A. J. Castro-Tirado, Sandra Savaglio, J. Quirola-Vásquez, Martin J. Dyer, Pietro Schipani, K. W. Smith, Lukasz Wyrzykowski, M. Della Valle, G. Pignata, S. D. Vergani, Jens Hjorth, A. S. B. Schultz, Mariusz Gromadzki, Saran Poshyachinda, Santiago González-Gaitán, Eugenio Maiorano, D. K. Galloway, Cesare Barbieri, V. D'Elia, Andrea Rossi, G. Ramsay, Seung-Lee Kim, Kornpob Bhirombhakdi, V. S. Dhillon, Enzo Brocato, Ilya Mandel, S. Benetti, J. D. Lyman, Sergio Campana, Fedor Getman, A. Sagués Carracedo, Kate Maguire, Arne Rau, A. S. Fruchter, John L. Tonry, B. P. Gompertz, Hanindyo Kuncarayakti, Kaj Wiik, Morgan Fraser, N. A. Walton, Stephan Rosswog, M. A.P. Torres, Claudia P. Gutiérrez, F. Ragosta, S. Piranomonte, A. Nicuesa Guelbenzu, S. H. Bruun, T. B. Lowe, M. E. Huber, S. J. Smartt, Gavin P. Lamb, S. Moran, Albino Perego, R. Eyles-Ferris, Stefano Covino, Istituto Nazionale di Fisica Nucleare, Sezione di Perugia (INFN, Sezione di Perugia), Istituto Nazionale di Fisica Nucleare (INFN), INAF - Osservatorio Astronomico di Brera (OAB), Istituto Nazionale di Astrofisica (INAF), Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Departamento de Astronomía y Astrofísica [Santiago], Pontificia Universidad Católica de Chile (UC), Instituto de Astrofísica de Andalucía (IAA), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Astrophysique Interprétation Modélisation (AIM (UMR7158 / UMR_E_9005 / UM_112)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Universitá degli Studi dell’Insubria = University of Insubria [Varese] (Uninsubria), Ecole Polytechnique Fédérale de Lausanne (EPFL), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, University of Sheffield [Sheffield], COBRA Research Institute, Eindhoven University of Technology, Aberystwyth University, AUTRES, Dark Cosmology Centre (DARK), Niels Bohr Institute [Copenhagen] (NBI), Faculty of Science [Copenhagen], University of Copenhagen = Københavns Universitet (UCPH)-University of Copenhagen = Københavns Universitet (UCPH)-Faculty of Science [Copenhagen], University of Copenhagen = Københavns Universitet (UCPH)-University of Copenhagen = Københavns Universitet (UCPH), Department of Physics [Pittsburgh], Carnegie Mellon University [Pittsburgh] (CMU), United States Geological Survey [Reston] (USGS), Faculty of Mathematics and Physics [Ljubljana] (FMF), University of Ljubljana, Department of Physics [Denver], University of Colorado [Denver], Laboratoire d'Acoustique de l'Université du Mans (LAUM), Le Mans Université (UM)-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), Oskar Klein Centre [Stockholm], Stockholm University, SRON Netherlands Institute for Space Research (SRON), Astrophysics Research Centre [Belfast] (ARC), Queen's University [Belfast] (QUB), Finnish Centre for Astronomy with ESO (FINCA), University of Turku, Institut Lavoisier de Versailles (ILV), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Scottish Universities Physics Alliance, Institute for Astronomy (SUPA), University of Edinburgh, Department of Agricultural and Environmental Sciences – Production, Landscape, Agroenergy, Università degli Studi di Milano = University of Milan (UNIMI), Universidad Nacional de Entre Ríos [Argentine] (UNER), Istituto di Astrofisica Spaziale e Fisica Cosmica - Milano (IASF-MI), INAF - Osservatorio Astronomico di Roma (OAR), INAF - Osservatorio Astronomico di Cagliari (OAC), Max-Planck-Institut für Extraterrestrische Physik (MPE), Bioénergétique fondamentale et appliquée, Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Università degli Studi di Milano-Bicocca = University of Milano-Bicocca (UNIMIB), University College Dublin [Dublin] (UCD), INAF-IASF Milano, Università della Calabria [Arcavacata di Rende] (Unical), INAF - Osservatorio Astronomico di Capodimonte (OAC), Woods Hole Oceanographic Institution (WHOI), National Institute of Water and Atmospheric Research [Wellington] (NIWA), Centre d'étude spatiale des rayonnements (CESR), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), University of Minnesota System, INAF - Osservatorio Astronomico di Padova (OAPD), Astronomical Observatory [Warsaw], Faculty of Physics [Warsaw] (FUW), University of Warsaw (UW)-University of Warsaw (UW), Astronomical Institute Anton Pannekoek (AI PANNEKOEK), University of Amsterdam [Amsterdam] (UvA), Galaxies, Etoiles, Physique, Instrumentation (GEPI), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Institute of Astronomy [Cambridge], University of Cambridge [UK] (CAM), Department of Physics and Astronomy [Leicester], University of Leicester, UniVersity, Nano Science and Technology Program, Department of Chemistry, The Hong Kong UniVersity of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, Hong Kong University of Science and Technology (HKUST), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Centre National d'Études Spatiales [Toulouse] (CNES), Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Universitá degli Studi dell’Insubria, University of Copenhagen = Københavns Universitet (KU)-University of Copenhagen = Københavns Universitet (KU)-Faculty of Science [Copenhagen], University of Copenhagen = Københavns Universitet (KU)-University of Copenhagen = Københavns Universitet (KU), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], University of Milan, Università degli Studi di Milano-Bicocca [Milano] (UNIMIB), Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Université Fédérale Toulouse Midi-Pyrénées-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées, Ackley, K., Amati, L., Barbieri, C., Bauer, F. E., Benetti, S., Bernardini, M. G., Bhirombhakdi, K., Botticella, M. T., Branchesi, M., Brocato, E., Bruun, S. H., Bulla, M., Campana, S., Cappellaro, E., Castro-Tirado, A. J., Chambers, K. C., Chaty, S., Chen, T. -W., Ciolfi, R., Coleiro, A., Copperwheat, C. M., Covino, S., Cutter, R., D'Ammando, F., D'Avanzo, P., De Cesare, G., D'Elia, V., Della Valle, M., Denneau, L., De Pasquale, M., Dhillon, V. S., Dyer, M. J., Elias-Rosa, N., Evans, P. A., Eyles-Ferris, R. A. J., Fiore, A., Fraser, M., Fruchter, A. S., Fynbo, J. P. U., Galbany, L., Gall, C., Galloway, D. K., Getman, F. I., Ghirlanda, G., Gillanders, J. H., Gomboc, A., Gompertz, B. P., Gonzalez-Fernandez, C., Gonzalez-Gaitan, S., Grado, A., Greco, G., Gromadzki, M., Groot, P. J., Gutierrez, C. P., Heikkila, T., Heintz, K. E., Hjorth, J., Hu, Y. -D., Huber, M. E., Inserra, C., Izzo, L., Japelj, J., Jerkstrand, A., Jin, Z. P., Jonker, P. G., Kankare, E., Kann, D. A., Kennedy, M., Kim, S., Klose, S., Kool, E. C., Kotak, R., Kuncarayakti, H., Lamb, G. P., Leloudas, G., Levan, A. J., Longo, F., Lowe, T. B., Lyman, J. D., Magnier, E., Maguire, K., Maiorano, E., Mandel, I., Mapelli, M., Mattila, S., Mcbrien, O. R., Melandri, A., Michalowski, M. J., Milvang-Jensen, B., Moran, S., Nicastro, L., Nicholl, M., Nicuesa Guelbenzu, A., Nuttal, L., Oates, S. R., O'Brien, P. T., Onori, F., Palazzi, E., Patricelli, B., Perego, A., Torres, M. A. P., Perley, D. A., Pian, E., Pignata, G., Piranomonte, S., Poshyachinda, S., Possenti, A., Pumo, M. L., Quirola-Vasquez, J., Ragosta, F., Ramsay, G., Rau, A., Rest, A., Reynolds, T. M., Rosetti, S. S., Rossi, A., Rosswog, S., Sabha, N. B., Sagues Carracedo, A., Salafia, O. S., Salmon, L., Salvaterra, R., Savaglio, S., Sbordone, L., Schady, P., Schipani, P., Schultz, A. S. B., Schweyer, T., Smartt, S. J., Smith, K. W., Smith, M., Sollerman, J., Srivastav, S., Stanway, E. R., Starling, R. L. C., Steeghs, D., Stratta, G., Stubbs, C. W., Tanvir, N. R., Testa, V., Thrane, E., Tonry, J. L., Turatto, M., Ulaczyk, K., Van Der Horst, A. J., Vergani, S. D., Walton, N. A., Watson, D., Wiersema, K., Wiik, K., Wyrzykowski, L., Yang, S., Yi, S. -X., Young, D. R., National Aeronautics and Space Administration (US), University of Hawaii, Queen's University Belfast, Space Telescope Science Institute (US), National Research Foundation (South Africa), National Astronomical Research Institute of Thailand, University of Portsmouth, Instituto de Astrofísica de Canarias, Science and Technology Facilities Council (UK), Ministerio de Economía, Fomento y Turismo (Chile), Comisión Nacional de Investigación Científica y Tecnológica (Chile), Ministerio de Ciencia, Innovación y Universidades (España), European Commission, Danish National Research Foundation, Alexander von Humboldt Foundation, Villum Fonden, Fundação para a Ciência e a Tecnologia (Portugal), Polish National Agency for Academic Exchange, Centre National de la Recherche Scientifique (CNRS)-Le Mans Université (UM), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Low Energy Astrophysics (API, FNWI), and API Other Research (FNWI)
Subjects: Astronomy, ELECTROMAGNETIC COUNTERPARTS, Supernovae: general, general [Supernovae], Binary number, Astrophysics, 7. Clean energy, 01 natural sciences, GW170817, neutron, Supernovae: general [Gravitational waves, Stars], 010303 astronomy & astrophysics, QC, QB, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, astro-ph.HE, [PHYS]Physics [physics], HAWK-I, [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], [SDU.ASTR.HE]Sciences of the Universe [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], EJECTA, Astrophysics - Solar and Stellar Astrophysics, GRAVITATIONAL-WAVE SOURCE, ST/P000495/1, Space Science, Astrophysics - High Energy Astrophysical Phenomena, Gravitational wave, astro-ph.SR, astro-ph.GA, FOS: Physical sciences, Context (language use), MASS, NO, GAMMA-RAY BURST, Gravitational waves, 0103 physical sciences, ST/T007184/1, Solar and Stellar Astrophysics (astro-ph.SR), STFC, 010308 nuclear & particles physics, Near-infrared spectroscopy, KILONOVA, RCUK, Stars: neutron, Astronomy and Astrophysics, neutron [Stars], R-PROCESS NUCLEOSYNTHESIS, Astrophysics - Astrophysics of Galaxies, EVOLUTION, Black hole, Neutron star, Space and Planetary Science, [SDU]Sciences of the Universe [physics], Astrophysics of Galaxies (astro-ph.GA), ST/P000312/1, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Gravitational waves, Stars: neutron, Supernovae: general
Abstract: Open Access article, published by EDP Sciences, under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.--Full list of authors: Ackley, K.; Amati, L.; Barbieri, C.; Bauer, F. E.; Benetti, S.; Bernardini, M. G.; Bhirombhakdi, K.; Botticella, M. T.; Branchesi, M.; Brocato, E.; Bruun, S. H.; Bulla, M.; Campana, S.; Cappellaro, E.; Castro-Tirado, A. J.; Chambers, K. C.; Chaty, S.; Chen, T. -W.; Ciolfi, R.; Coleiro, A.; Copperwheat, C. M.; Covino, S.; Cutter, R.; D'Ammando, F.; D'Avanzo, P.; De Cesare, G.; D'Elia, V.; Della Valle, M.; Denneau, L.; De Pasquale, M.; Dhillon, V. S.; Dyer, M. J.; Elias-Rosa, N.; Evans, P. A.; Eyles-Ferris, R. A. J.; Fiore, A.; Fraser, M.; Fruchter, A. S.; Fynbo, J. P. U.; Galbany, L.; Gall, C.; Galloway, D. K.; Getman, F. I.; Ghirlanda, G.; Gillanders, J. H.; Gomboc, A.; Gompertz, B. P.; González-Fernández, C.; González-Gaitán, S.; Grado, A.; Greco, G.; Gromadzki, M.; Groot, P. J.; Gutiérrez, C. P.; Heikkilä, T.; Heintz, K. E.; Hjorth, J.; Hu, Y. -D.; Huber, M. E.; Inserra, C.; Izzo, L.; Japelj, J.; Jerkstrand, A.; Jin, Z. P.; Jonker, P. G.; Kankare, E.; Kann, D. A.; Kennedy, M.; Kim, S.; Klose, S.; Kool, E. C.; Kotak, R.; Kuncarayakti, H.; Lamb, G. P.; Leloudas, G.; Levan, A. J.; Longo, F.; Lowe, T. B.; Lyman, J. D.; Magnier, E.; Maguire, K.; Maiorano, E.; Mandel, I.; Mapelli, M.; Mattila, S.; McBrien, O. R.; Melandri, A.; Michałowski, M. J.; Milvang-Jensen, B.; Moran, S.; Nicastro, L.; Nicholl, M.; Nicuesa Guelbenzu, A.; Nuttal, L.; Oates, S. R.; O'Brien, P. T.; Onori, F.; Palazzi, E.; Patricelli, B.; Perego, A.; Torres, M. A. P.; Perley, D. A.; Pian, E.; Pignata, G.; Piranomonte, S.; Poshyachinda, S.; Possenti, A.; Pumo, M. L.; Quirola-Vásquez, J.; Ragosta, F.; Ramsay, G.; Rau, A.; Rest, A.; Reynolds, T. M.; Rosetti, S. S.; Rossi, A.; Rosswog, S.; Sabha, N. B.; Sagués Carracedo, A.; Salafia, O. S.; Salmon, L.; Salvaterra, R.; Savaglio, S.; Sbordone, L.; Schady, P.; Schipani, P.; Schultz, A. S. B.; Schweyer, T.; Smartt, S. J.; Smith, K. W.; Smith, M.; Sollerman, J.; Srivastav, S.; Stanway, E. R.; Starling, R. L. C.; Steeghs, D.; Stratta, G.; Stubbs, C. W.; Tanvir, N. R.; Testa, V.; Thrane, E.; Tonry, J. L.; Turatto, M.; Ulaczyk, K.; van der Horst, A. J.; Vergani, S. D.; Walton, N. A.; Watson, D.; Wiersema, K.; Wiik, K.; Wyrzykowski, Ł.; Yang, S.; Yi, S. -X.; Young, D. R., Context. Gravitational wave (GW) astronomy has rapidly reached maturity, becoming a fundamental observing window for modern astrophysics. The coalescences of a few tens of black hole (BH) binaries have been detected, while the number of events possibly including a neutron star (NS) is still limited to a few. On 2019 August 14, the LIGO and Virgo interferometers detected a high-significance event labelled S190814bv. A preliminary analysis of the GW data suggests that the event was likely due to the merger of a compact binary system formed by a BH and a NS. Aims. In this paper, we present our extensive search campaign aimed at uncovering the potential optical and near infrared electromagnetic counterpart of S190814bv. We found no convincing electromagnetic counterpart in our data. We therefore use our non-detection to place limits on the properties of the putative outflows that could have been produced by the binary during and after the merger. Methods. Thanks to the three-detector observation of S190814bv, and given the characteristics of the signal, the LIGO and Virgo Collaborations delivered a relatively narrow localisation in low latency - a 50% (90%) credible area of 5 deg2 (23 deg2) - despite the relatively large distance of 267 ± 52 Mpc. ElectromagNetic counterparts of GRAvitational wave sources at the VEry Large Telescope collaboration members carried out an intensive multi-epoch, multi-instrument observational campaign to identify the possible optical and near infrared counterpart of the event. In addition, the ATLAS, GOTO, GRAWITA-VST, Pan-STARRS, and VINROUGE projects also carried out a search on this event. In this paper, we describe the combined observational campaign of these groups. Results. Our observations allow us to place limits on the presence of any counterpart and discuss the implications for the kilonova (KN), which was possibly generated by this NS-BH merger, and for the strategy of future searches. The typical depth of our wide-field observations, which cover most of the projected sky localisation probability (up to 99.8%, depending on the night and filter considered), is r ∼ 22 (resp. K ∼ 21) in the optical (resp. near infrared). We reach deeper limits in a subset of our galaxy-targeted observations, which cover a total ∼50% of the galaxy-mass-weighted localisation probability. Altogether, our observations allow us to exclude a KN with large ejecta mass M 0.1 M- to a high (> 90%) confidence, and we can exclude much smaller masses in a sub-sample of our observations. This disfavours the tidal disruption of the neutron star during the merger. Conclusions. Despite the sensitive instruments involved in the campaign, given the distance of S190814bv, we could not reach sufficiently deep limits to constrain a KN comparable in luminosity to AT 2017gfo on a large fraction of the localisation probability. This suggests that future (likely common) events at a few hundred megaparsecs will be detected only by large facilities with both a high sensitivity and large field of view. Galaxy-targeted observations can reach the needed depth over a relevant portion of the localisation probability with a smaller investment of resources, but the number of galaxies to be targeted in order to get a fairly complete coverage is large, even in the case of a localisation as good as that of this event. © K. Ackley et al. 2020., Based on observations collected at the European Southern Observatory under ESO programmes 1102.D-0353(E), 1102.D0353(F), 1102.D-0353(Q), 1102.D-0353(G), 0103.D-0070(A), 0103.D-0070(B), 0103.D-0703(A), 0103.D-0722(A), 0103.A-9099(A), 198.D-2010(D) and 60.A9285(A). ATLAS is primarily funded through NEO NASA grants NN12AR55G, 80NSSC18K0284, and 80NSSC18K1575. The ATLAS science products have been made possible through the contributions of the University of Hawaii IfA, the Queen's University Belfast, the Space Telescope Science Institute, and the South African Astronomical Observatory. PanSTARRS is primarily funded through NEO NASA grants NASA Grants NNX08AR22G, NNX14AM74G. The PanSTARRS science products for LIGO-Virgo follow-up are made possible through the contributions of the University of Hawaii IfA and the Queen's University Belfast. The Gravitational-wave Optical Transient Observer (GOTO) project acknowledges the support of the Monash-Warwick Alliance; Warwick University; Monash University; She ffield University; Leicester University; Armagh Observatory & Planetarium; the National Astronomical Research Institute of Thailand (NARIT); University of Portsmouth; Turku University and the Instituto de Astrofisica de Canarias (IAC). Part of the funding for GROND was generously granted from the Leibniz-Prize to Prof. G. Hasinger (DFG grant HA 1850/28-1). The Liverpool Telescope is operated on the island of La Palma by Liverpool John Moores University in the Spanish Observatorio del Roque de los Muchachos of the Instituto de Astrofisica de Canarias with financial support from the UK Science and Technology Facilities Council. The WHT and its override programme are operated on the island of La Palma by the Isaac Newton Group of Telescopes in the Spanish Observatorio del Roque de los Muchachos of the Instituto de Astrofisica de Canarias; part of these data were taken under program (19A)N3. FEB thanks CONICYT Basal AFB-170002 and Chile's Ministry of Economy fund IC120009. MGB, PDA and AM acknowledge support from ASI grant I/004/11/3. MBr, EC, AP and SPi acknowledge support from MIUR (PRIN 2017 grant 20179ZF5KS). EB, EM and MT acknowledge funding from GRAWITA. SHB is indebted to the Danish National Research Foundation (DNRF132) for support. SCa acknowledges support from grant MAE0065741. EC acknowledges the support of the H2020 OPTICON programme 730890. TWC acknowledges the Humboldt Foundation and Marie Sklodowska-Curie grant 842471. MDP thanks Istanbul University for support. PAE acknowledges UKSA support. RAJEF is supported by an STFC studentship. MF is supported by a Royal Society -SFI University Research Fellowship. LG was funded by the EU H2020 programme under MSCA grant no. 839090. CG, JH and LI were supported by a research grant from VILLUM FONDEN (project 16599). CG and LI were supported by a research grant from VILLUM FONDEN (25501). GGh acknowledges the PRIN MIUR "Figaro" for financial support. AGo acknowledges financial support from the Slovenian Research Agency (grants P1-0031, I0-0033, and J1-8136). BPG, AJL and JDL acknowledge support from ERC grant 725246 (TEDE, PI Levan). SGG acknowledges support by FCT Fundacao para a Ciencia e Tecnologia and by Project PTDC/FIS-AST-31546. GGr acknowledges the ESCAPE H2020 project no. 824064. MG is supported by the Polish NCN MAESTRO grant 2014/14/A/ST9/00121. PJG acknowledges support from NOVA and from the South African NRF SARChI grant 111692. CPG and MS acknowledge support from EU/FP7-ERC grant no. 615929. KEH acknowledges support by a Project Grant from The Icelandic Research Fund. YDH acknowledges support from the China Scholarships Council. JJ acknowledges support from NOVA and NWO-FAPESP grant for instrumentation. AJ acknowledges funding from the European Research Council (ERC). ZPJ was supported by the Foundation for Distinguished Young Scholars of Jiangsu Province (no. BK20180050). PGJ acknowledges funding from the ERC under Consolidator Grant agreement no. 647208. DAK acknowledges Spanish research project RTI2018-098104-J-I00 (GRBPhot). SKl acknowledges support by DFG grant Kl 766/16-3. ECK acknowledges support from the GREAT research environment. GPL acknowledges support from STFC via grant ST/N000757/1. GL was supported by a research grant (19054) from VILLUM FONDEN. KM acknowledges support from the ERC (grant no. 758638). IM is partially supported by OzGrav (ARC project CE17010000). MMacknowledges support from ERC through ERC-2017-CoG no. 770017. MJM acknowledges the National Science Centre, Poland, grant 2018/30/E/ST9/00208. BMJ and DW are supported by Independent Research Fund Denmark grant DFF-7014-00017. MN is supported by a Royal Astronomical Society Research Fellowship. ANG acknowledges support by grant DFG Kl 766/16-3. PTOB acknowledges funding from STFC. SRO gratefully acknowledges the support of the Leverhulme Trust. FO acknowledges the support of the H2020 Hemera program, grant no. 730970. MAPT was supported by grants RYC-2015-17854 and AYA201783216-P. EP aknowledges financial support from INAF. GP is supported by the Millennium Science Initiative through grant IC120009. MLP is partially supported by a "Linea 2" project of the Catania University. JQV acknowledges support from CONICYT folio 21180886. TMR acknowledges the support of the Vilho, Yrjo and Kalle Vaisala Foundation. ARo acknowledges support from Premiale LBT 2013. SR is supported by VR grants 2016-03657_3 and the research environment grant GREAT, Dnr. 2016-06012, and the Swedish National Space board, Dnr. 107/16. OSS acknowledges the Italian Ministry of Research (MIUR) grant 1.05.06.13. LSa acknowledges the Irish Research Council Scholarship no. GOIPG/2017/1525. SJS acknowledges support from STFC Grant ST/P000312/1. ERS and DS acknowledge funding from UK STFC CG ST/P000495/1. RLCS acknowledges funding from STFC. DS acknowledges support from STFC via grant ST/T007184/1. SDV acknowledges the support of the CNES. LWsupported by Polish NCN DAINA 2017/27/L/ST9/03221. The Cosmic DAWN center is funded by the Danish National Research Foundation.
Published: 2020

39. Exploitation of bacterial N-linked glycosylation to develop a novel recombinant glycoconjugate vaccine against Francisella tularensis

Author: Jon Cuccui, Rebecca M. Thomas, Madeleine G. Moule, Riccardo V. D'Elia, Thomas R. Laws, Dominic C. Mills, Diane Williamson, Timothy P. Atkins, Joann L. Prior, and Brendan W. Wren
Subjects: francisella tularensis, vaccine, glycoconjugate, protein glycan coupling technology, Biology (General), QH301-705.5
Abstract: Glycoconjugate-based vaccines have proved to be effective at producing long-lasting protection against numerous pathogens. Here, we describe the application of bacterial protein glycan coupling technology (PGCT) to generate a novel recombinant glycoconjugate vaccine. We demonstrate the conjugation of the Francisella tularensis O-antigen to the Pseudomonas aeruginosa carrier protein exotoxin A using the Campylobacter jejuni PglB oligosaccharyltransferase. The resultant recombinant F. tularensis glycoconjugate vaccine is expressed in Escherichia coli where yields of 3 mg l−1 of culture were routinely produced in a single-step purification process. Vaccination of BALB/c mice with the purified glycoconjugate boosted IgG levels and significantly increased the time to death upon subsequent challenge with F. tularensis subsp. holarctica. PGCT allows different polysaccharide and protein combinations to be produced recombinantly and could be easily applicable for the production of diverse glycoconjugate vaccines.
Published: 2013
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40. Glucosamine-NISV delivers antibody across the blood-brain barrier: Optimization for treatment of encephalitic viruses

Author: Wendy Butcher, Lyn M. O'Brien, F. Javier Salguero, E. Diane Williamson, Francesca Modino, Stuart Woods, Ana R. Georgian, Craig W. Roberts, Jane E. Preston, N. Joan Abbott, and Riccardo V. D'Elia
Subjects: Endosome, Pharmaceutical Science, 02 engineering and technology, Blood–brain barrier, Clathrin, RS, Encephalitis Virus, Venezuelan Equine, 03 medical and health sciences, Mice, Surface-Active Agents, medicine, Animals, Horses, 030304 developmental biology, Dynamin, 0303 health sciences, Glucosamine, biology, Chemistry, Vesicle, 021001 nanoscience & nanotechnology, Cell biology, medicine.anatomical_structure, Transcytosis, Blood-Brain Barrier, Drug delivery, biology.protein, Sorting endosome, 0210 nano-technology
Abstract: The field of brain drug delivery faces many challenges that hinder development and testing of novel therapies for clinically important central nervous system disorders. Chief among them is how to deliver large biologics across the highly restrictive blood-brain barrier. Non-ionic surfactant vesicles (NISV) have long been used as a drug delivery platform for cutaneous applications and have benefits over comparable liposomes in terms of greater stability, lower cost and suitability for large scale production. Here we describe a glucosamine-coated NISV, for blood-brain barrier GLUT1 targeting, capable of traversing the barrier and delivering active antibody to cells within the brain. In vitro, we show glucosamine vesicle transcytosis across the blood-brain barrier with intact cargo, which is partially dynamin-dependent, but is clathrin-independent and does not associate with sorting endosome marker EEA1. Uptake of vesicles into astrocytes follows a more classical pathway involving dynamin, clathrin, sorting endosomes and Golgi trafficking where the cargo is released intracellularly. In vivo, glucosamine-coated vesicles are superior to uncoated or transferrin-coated vesicles for delivering cargo to the mouse brain. Finally, mice infected with Venezuelan equine encephalitis virus (VEEV) were successfully treated with anti-VEEV monoclonal antibody Hu1A3B-7 delivered in glucosamine-coated vesicles and had improved survival and reduced brain tissue virus levels. An additional benefit was that the treatment also reduced viral load in peripheral tissues. The data generated highlights the huge potential of glucosamine-decorated NISV as a drug delivery platform with wider potential applications.
Published: 2020

41. Open Universe survey of Swift-XRT GRB fields: Flux-limited sample of HBL blazars

Author: J. Del Rio Vera, Y. L. Chang, Carlos Brandt, N. Ricard, S. Di Pippo, Narek Sahakyan, Remo Ruffini, M. Perri, Theo Glauch, M. Capalbi, P. Giommi, M. De Angelis, A. M. T. Pollock, F. Arneodo, S. Puccetti, A. V. Penacchioni, R. Middei, O. Civitarese, S. Turriziani, U. Barres de Almeida, A. Di Giovanni, V. D'Elia, F. Verrecchia, Paolo Padovani, C. Leto, ITA, GBR, DEU, ARG, ARM, AUT, BRA, TWN, ARE, and RUS
Subjects: Swift, Physics, Open universe, 010504 meteorology & atmospheric sciences, Astrophysics::High Energy Astrophysical Phenomena, Flux, Astronomy and Astrophysics, Astrophysics, 01 natural sciences, Sample (graphics), Space and Planetary Science, 0103 physical sciences, Blazar, Gamma-ray burst, 010303 astronomy & astrophysics, computer, 0105 earth and related environmental sciences, computer.programming_language
Abstract: Aims. The sample of serendipitous sources detected in all Swift-XRT images pointing at gamma ray bursts (GRBs) constitutes the largest existing medium-deep survey of the X-ray sky. To build such dataset we analysed all Swift X-ray images centred on GRBs and observed over a period of 15 years using automatic tools that do not require any expertise in X-ray astronomy. Besides presenting a new large X-ray survey and a complete sample of blazars, this work aims to be a step in the direction of achieving the ultimate goal of the Open Universe Initiative, which is to enable non-expert people to benefit fully from space science data, possibly extending the potential for scientific discovery, which is currently confined within a small number of highly specialised teams, to a much larger population. Methods. We used the Swift_deepsky Docker container encapsulated pipeline to build the largest existing flux-limited and unbiased sample of serendipitous X-ray sources. Swift_deepsky runs on any laptop or desktop computer with a modern operating system. The tool automatically downloads the data and the calibration files from the archives, runs the official Swift analysis software, and produces a number of results including images, the list of detected sources, X-ray fluxes, spectral energy distribution data, and spectral slope estimations. Results. We used our source list to build the LogN-LogS of extra-galactic sources, which perfectly matches that estimated by other satellites. Combining our survey with multi-frequency data, we selected a complete radio-flux-density-limited sample of high energy peaked blazars (HBL). The LogN-LogS built with this data set confirms that previous samples are incomplete below ∼20 mJy.
Published: 2020

42. A comparison between short GRB afterglows and kilonova AT2017gfo: Shedding light on kilonovae properties

Author: A. Grado, Vincenzo Testa, J. B. Stephen, Albino Perego, Elena Pian, Stefano Covino, Andrea Rossi, M. Dadina, Ruben Salvaterra, Enzo Brocato, Lorenzo Amati, D. Vergani, A. Melandri, G. Stratta, Luca Izzo, A. Gardini, N. Masetti, S. Piranomonte, L. Tomasella, Elisabetta Maiorano, Riccardo Ciolfi, Sheng Yang, Jonatan Selsing, Eliana Palazzi, Luciano Nicastro, V. D'Elia, S. Benetti, D. Spighi, M. Branchesi, ITA, FRA, and Istituto Nazionale di Astrofisica
Subjects: Physics, High Energy Astrophysical Phenomena (astro-ph.HE), Neutron star mergers, stars: magnetars, Gamma-ray burst: general, Astronomy, FOS: Physical sciences, Astronomy and Astrophysics, Kilonova, general, Gamma-ray bursts, Gravitational waves, Stars: magnetars [Gamma-ray burst], Gravitational-wave astronomy, general [Gamma-ray burst], magnetars [Stars], Space and Planetary Science, Astrophysics - High Energy Astrophysical Phenomena, Gamma-ray burst
Abstract: Multimessenger astronomy received a great boost following the discovery of kilonova (KN) AT2017gfo, the optical counterpart of the gravitational wave source GW170817 associated with the short gamma-ray burst GRB 170817A. AT2017gfo was the first KN that could be extensively monitored in time using both photometry and spectroscopy. Previously, only few candidates have been observed against the glare of short GRB afterglows. In this work, we aim to search the fingerprints of AT2017gfo-like KN emissions in the optical/NIR light curves of 39 short GRBs with known redshift. For the first time, our results allow us to study separately the range of luminosity of the blue and red components of AT2017gfo-like kilonovae in short GRBs. In particular, the red component is similar in luminosity to AT2017gfo, while the blue KN can be more than 10 times brighter. Finally, we exclude a KN as luminous as AT2017gfo in GRBs 050509B and 061201.C 2020 The Author(s) Published by Oxford University Press on behalf of the Royal Astronomical Society, The authors thank the anonymous referee for a very constructive report. We thankD. Radice for useful discussion about theKNmodels, and G. Raimondo for valuable suggestions. AR acknowledges support from INAF project 'Premiale LBT 2013'. We acknowledge support from INAF for the PRIN INAF 2016 project 'Toward the SKA and CTA era: discovery, localization, and physics of transient sources' (P.I. M. Giroletti). We also acknowledge INAF financial support of the project 'Gravitational Wave Astronomy with the first detections of adLIGO and adVIRGO experiments'. This work made use of the Weizmann interactive supernova data repository -http://wiserep.weizmann.ac.il.This research has made use of the NASA/IPAC Infrared Science Archive, which is operated by the Jet Propulsion Laboratory, California Institute of Technology, under contract with the National Aeronautics and Space Administration.
Published: 2020

43. GRB 190114C in the nuclear region of an interacting galaxy: A detailed host analysis using ALMA, the HST, and the VLT

Author: A. J. van der Horst, S. D. Vergani, Nial R. Tanvir, Steve Schulze, B. Sbarufatti, A. M. Rossi, D. A. Perley, D. A. Kann, Ruben Salvaterra, M. de Pasquale, R. Sanchez-Ramirez, Luca Izzo, Dan M. Watson, J. T. Palmerio, A. J. Levan, Sergio Martín, A. S. Fruchter, J. P. U. Fynbo, Pall Jakobsson, D. H. Hartmann, Stefano Covino, Kasper E. Heintz, Michał J. Michałowski, C. C. Thöne, J. Japelj, A. de Ugarte Postigo, Da Xu, K. Bensch, Jonatan Selsing, V. D'Elia, Kenny C. Y. Ng, Galaxies, Etoiles, Physique, Instrumentation (GEPI), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Centre National de la Recherche Scientifique (CNRS), Institut d'Astrophysique de Paris (IAP), Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Ministerio de Economía y Competitividad (España), European Commission, Ministerio de Ciencia, Innovación y Universidades (España), National Science Centre (Poland), Carlsberg Foundation, Icelandic Research Fund, Independent Research Fund Denmark, Danish National Research Foundation, and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Infrared, Astronomy, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, DUST, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, STAR-FORMATION, CORE-COLLAPSE SUPERNOVAE, 0103 physical sciences, SPECTRA, Spectroscopy, individual: 190114C [gamma-ray burst], 010303 astronomy & astrophysics, molecules [ISM], QC, Astrophysics::Galaxy Astrophysics, QB, High Energy Astrophysical Phenomena (astro-ph.HE), GAMMA-RAY BURSTS, LEGACY SURVEY, CALIBRATION, Physics, [PHYS]Physics [physics], gamma-ray burst: individual: 190114C, ISM [galaxies], 010308 nuclear & particles physics, Astronomy and Astrophysics, Astrophysics - Astrophysics of Galaxies, MOLECULAR GAS, Redshift, Galaxy, ISM: molecules, Delta-v (physics), ENERGY AFTERGLOW EMISSION, 13. Climate action, Space and Planetary Science, Astrophysics of Galaxies (astro-ph.GA), galaxies: star formation, Astrophysics::Earth and Planetary Astrophysics, star formation [galaxies], SKY SURVEY, Gamma-ray burst, Astrophysics - High Energy Astrophysical Phenomena, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Host (network), Event (particle physics), galaxies: ISM
Abstract: Context. For the first time, very high energy emission up to the TeV range has been reported for a gamma-ray burst (GRB). It is still unclear whether the environmental properties of GRB 190114C might have contributed to the production of these very high energy photons, or if it is solely related to the released GRB emission. Aims. The relatively low redshift of the GRB (z = 0.425) allows us to study the host galaxy of this event in detail, and to potentially identify idiosyncrasies that could point to progenitor characteristics or environmental properties that might be responsible for this unique event. Methods. We used ultraviolet, optical, infrared, and submillimetre imaging and spectroscopy obtained with the HST, the VLT, and ALMA to obtain an extensive dataset on which the analysis of the host galaxy is based. Results. The host system is composed of a close pair of interacting galaxies (Δv = 50 km s-1), both of which are well detected by ALMA in CO(3-2). The GRB occurred within the nuclear region (∼170 pc from the centre) of the less massive but more star-forming galaxy of the pair. The host is more massive (log(M/M⊙ ) = 9.3) than average GRB hosts at this redshift, and the location of the GRB is rather unique. The higher star formation rate was probably triggered by tidal interactions between the two galaxies. Our ALMA observations indicate that both host galaxy and companion have a high molecular gas fraction, as has been observed before in interacting galaxy pairs. Conclusions. The location of the GRB within the core of an interacting galaxy with an extinguished line of sight is indicative of a denser environment than typically observed for GRBs and could have been crucial for the generation of the very high energy photons that were observed. © ESO 2020., This paper makes use of the following ALMA data: ADS/JAO.ALMA#2018.A.00020.T. ALMA is a partnership of ESO (representing its member states), NSF (USA) and NINS (Japan), together with NRC (Canada), MOST and ASIAA (Taiwan), and KASI (Republic of Korea), in cooperation with the Republic of Chile. The Joint ALMA Observatory is operated by ESO, AUI/NRAO and NAOJ. CT, AdUP, DAK, MB, and LI acknowledge support from the Spanish research project AYA2017-89384-P. CT and AdUP acknowledge support from funding associated to Ramon y Cajal fellowships (RyC-2012-09984 and RyC-2012-09975). DAK acknowledges support from the Spanish research project RTI2018-098104-J-I00. M.J.M. acknowledges the support of the National Science Centre, Poland through the SONATA BIS grant 2018/30/E/ST9/00208. JPUF thanks the Carlsberg Foundation for support. KEH and PJ acknowledge support by a Project Grant (162948-051) from The Icelandic Research Fund. JS and DW are supported in part by Independent Research Fund Denmark grant DFF-7014-00017. The Cosmic Dawn Center is supported by the Danish National Research Foundation under grant No. 140.
Published: 2020

44. New Hard-TeV Extreme Blazars Detected with the MAGIC Telescopes*

Author: D. Fidalgo, K. Nishijima, R. Mirzoyan, B. Machado de Oliveira Fraga, P. Majumdar, P. Temnikov, L. Bellizzi, H. Kubo, M. Vazquez Acosta, M. I. Martínez, B. De Lotto, D. Dominis Prester, S. Paiano, I. Šnidarić, C. Nigro, Y. Iwamura, A. Carosi, Stefano Covino, M. Makariev, Alice Donini, A. Rugliancich, P. Munar-Adrover, G. Vanzo, Satoshi Fukami, John Hoang, Massimo Persic, J. Becerra González, Kazuma Ishio, T. Saito, S. Ansoldi, M. Palatiello, V. Fallah Ramazani, Jordi Delgado, C. Maggio, M. Delfino, S. Gasparyan, Elisa Prandini, Francesco Dazzi, Saverio Lombardi, A. Lamastra, Saša Mićanović, A. Berti, V. Vitale, J. Kushida, Kari Nilsson, Dario Hrupec, D. Lelas, A. Arbet Engels, M. Mallamaci, L. Maraschi, Elisa Bernardini, Fabrizio Tavecchio, P. Peñil, Vitaly Neustroev, Elina Lindfors, Ll. Font, M. Peresano, K. Noda, U. Colin, N. Godinović, Mitsunari Takahashi, E. Molina, David Paneque, A. Biland, W. Bednarek, W. Bhattacharyya, A. Fattorini, Ž. Bošnjak, M. Will, Anne M. Lohfink, A. Somero, Luca Tosti, Antonio Stamerra, P. Da Vela, C. Fruck, F. D'Ammando, D. Guberman, Katsuaki Asano, K. Mannheim, R. Carosi, M. Minev, Francesco Longo, Jose Luis Contreras, M. Teshima, A. Hahn, R. J. García López, G. Maneva, L. Nogués, Susumu Inoue, I. Puljak, M. V. Fonseca, Abelardo Moralejo, Nicola Giglietto, J. van Scherpenberg, Juan Cortina, Ferdinando Giordano, Kevin Schmidt, E. Moretti, D. Miceli, U. Barres de Almeida, Victoria Moreno, Valerio Vagelli, B. Banerjee, Shunsuke Sakurai, A. Babić, F. Di Pierro, D. Hadasch, M. Ribó, Oscar Blanch, T. Schweizer, Serena Loporchio, Marina Manganaro, A. De Angelis, A. Chilingaryan, Dominik Baack, M. Strzys, S. Cikota, Daniel Kerszberg, P. G. Prada Moroni, Chiara Righi, V. D'Elia, Wolfgang Rhode, G. Ceribella, M. López, Konstancja Satalecka, D. Mazin, Michele Doro, C. Arcaro, G. Busetto, Ciro Bigongiari, D. Zarić, Matteo Cerruti, R. López-Coto, Tomohiro Inada, J. Herrera, Léa Jouvin, F. Leone, Julian Sitarek, G. Ferrara, D. Dorner, Louis Antonelli, E. Colombo, D. Morcuende, N. Torres-Albà, M. Garczarczyk, I. Vovk, Dorota Sobczyńska, Victor A. Acciari, Y. Chai, Moritz Hütten, D. Strom, J. Rico, R. Paoletti, J. Besenrieder, David H. Green, T. Surić, M. Gaug, L. Di Venere, G. Bonnoli, D. Elsaesser, D. Ninci, Jose Miguel Miranda, E. Do Souto Espiñeira, Tomislav Terzić, S. M. Colak, Juan Abel Barrio, Narek Sahakyan, A. López-Oramas, Yusuke Suda, Carlo Vigorito, L. Saha, J. M. Paredes, Francesco Tombesi, Seiya Nozaki, Davide Depaoli, L. Foffano, M. Mariotti, Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), MAGIC, Acciari, V. A., Ansoldi, S., Antonelli, L. A., Engels, A. A., Asano, K., Baack, D., Babic, A., Banerjee, B., De Almeida, U. B., Barrio, J. A., Gonzalez, J. B., Bednarek, W., Bellizzi, L., Bernardini, E., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bonnoli, G., Bosnjak, Z., Busetto, G., Carosi, R., Ceribella, G., Cerruti, M., Chai, Y., Chilingaryan, A., Cikota, S., Colak, S. M., Colin, U., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D'Elia, V., Vela, P. D., Dazzi, F., Angelis, A. D., Lotto, B. D., Delfino, M., Delgado, J., Depaoli, D., Pierro, F. D., Venere, L. D., Souto Espieira, E. D., Prester, D. D., Donini, A., Dorner, D., Doro, M., Elsaesser, D., Ramazani, V. F., Fattorini, A., Ferrara, G., Fidalgo, D., Foffano, L., Fonseca, M. V., Font, L., Fruck, C., Fukami, S., Lopez, R. J. G., Garczarczyk, M., Gasparyan, S., Gaug, M., Giglietto, N., Giordano, F., Godinovic, N., Green, D., Guberman, D., Hadasch, D., Hahn, A., Herrera, J., Hoang, J., Hrupec, D., Hutten, M., Inada, T., Inoue, S., Ishio, K., Iwamura, Y., Jouvin, L., Kerszberg, D., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Lombardi, S., Longo, F., Lopez, M., Lopez-Coto, R., Lopez-Oramas, A., Loporchio, S., De Oliveira Fraga, B. M., Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martinez, M., Mazin, D., Micanovic, S., Miceli, D., Minev, M., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Morcuende, D., Moreno, V., Moretti, E., Munar-Adrover, P., Neustroev, V., Nigro, C., Nilsson, K., Ninci, D., Nishijima, K., Noda, K., Nogues, L., Nozaki, S., Paiano, S., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Peil, P., Peresano, M., Persic, M., Moroni, P. G. P., Prandini, E., Puljak, I., Rhode, W., Ribo, M., Rico, J., Righi, C., Rugliancich, A., Saha, L., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Schmidt, K., Schweizer, T., Sitarek, J., Snidaric, I., Sobczynska, D., Somero, A., Stamerra, A., Strom, D., Strzys, M., Suda, Y., Suric, T., Takahashi, M., Tavecchio, F., Temnikov, P., Terzic, T., Teshima, M., Torres-Alb, N., Tosti, L., Vagelli, V., Scherpenberg, J. V., Vanzo, G., Acosta, M. V., Vigorito, C. F., Vitale, V., Vovk, I., Will, M., Zaric, D., Arcaro, C., Carosi, A., D'Ammando, F., Tombesi, F., Lohfink, A., 30588766 - Arcaro, Cornelia, Laboratoire d'Annecy de Physique des Particules (LAPP), German Research Foundation, Istituto Nazionale di Fisica Nucleare, Swiss National Science Foundation, Ministerio de Economía y Competitividad (España), Department of Atomic Energy (India), Japan Society for the Promotion of Science, Ministry of Education, Culture, Sports, Science and Technology (Japan), Academy of Finland, Croatian Science Foundation, University of Rijeka, Polish National Agency for Academic Exchange, and European Commission
Subjects: Non-thermal radiation sources, VHE [gamma ray], Non-thermal radiation source, Astrophysics, 01 natural sciences, Relativistic jet, MAGIC (telescope), 010303 astronomy & astrophysics, model: leptonic, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, astro-ph.HE, education.field_of_study, Gamma ray, gamma ray: emission, quality, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Astrophysics of Galaxies, BL Lacertae objects, Física nuclear, Catalog, Astrophysics and Astronomy, astro-ph.GA, Astrophysics::High Energy Astrophysical Phenomena, Population, energy spectrum, FOS: Physical sciences, Proton Synchrotron, magnetization, BL Lacertae object, leptonic [model], blazar, X-ray, Settore FIS/05 - Astronomia e Astrofisica, emission [gamma ray], 0103 physical sciences, synchrotron, education, Blazar, Active galactic nuclei, Gamma-ray sources, X-ray active galactic nuclei, 010308 nuclear & particles physics, Spectral density, Astronomy and Astrophysics, Catalogues, proton synchrotron, MAGIC, Synchrotron emission, Blazars, Relativistic jets, Catalogs, Automatic Keywords, gamma ray: VHE, Space and Planetary Science, Astrophysics of Galaxies (astro-ph.GA), ddc:520, spectral, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract: Extreme high-frequency-peaked BL Lac objects (EHBLs) are blazars that exhibit extremely energetic synchrotron emission. They also feature nonthermal gamma-ray emission whose peak lies in the very high-energy (VHE, E > 100 GeV) range, and in some sources exceeds 1 TeV: this is the case for hard-TeV EHBLs such as 1ES 0229+200. With the aim of increasing the EHBL population, 10 targets were observed with the MAGIC telescopes from 2010 to 2017, for a total of 265 hr of good-quality data. The data were complemented by coordinated Swift observations. The X-ray data analysis confirms that all but two sources are EHBLs. The sources show only a modest variability and a harder-when-brighter behavior, typical for this class of objects. At VHE gamma-rays, three new sources were detected and a hint of a signal was found for another new source. In each case, the intrinsic spectrum is compatible with the hypothesis of a hard-TeV nature of these EHBLs. The broadband spectral energy distributions (SEDs) of all sources are built and modeled in the framework of a single-zone, purely leptonic model. The VHE gamma-ray-detected sources were also interpreted with a spine-layer model and a proton synchrotron model. The three models provide a good description of the SEDs. However, the resulting parameters differ substantially in the three scenarios, in particular the magnetization parameter. This work presents the first mini catalog of VHE gamma-ray and multiwavelength observations of EHBLs., We would like to thank the Instituto de Astrofísica de Canarias for the excellent working conditions at the Observatorio del Roque de los Muchachos in La Palma. The financial support of the German BMBF and MPG, the Italian INFN and INAF, the Swiss National Fund SNF, the ERDF under the Spanish MINECO (FPA2015-69818-P, FPA2012-36668, FPA 2015-68378-P, FPA2017-82729-C6-2-R, FPA2015-69210-C6- 4-R, FPA2015-69210-C6-6-R, AYA2015-71042-P, AYA2016- 76012-C3-1-P, ESP2015-71662-C2-2-P, FPA2017-90566-RE DC), the Indian Department of Atomic Energy, the Japanese JSPS and MEXT, the Bulgarian Ministry of Education and Science, National RI Roadmap Project DO1-153/28.08.2018, and the Academy of Finland grant nr. 320045 is gratefully acknowledged. This work was also supported by the Spanish Centro de Excelencia “Severo Ochoa” SEV-2016-0588 and SEV-2015-0548, and Unidad de Excelencia “María de Maeztu” MDM-2014-0369, by the Croatian Science Foundation (HrZZ) Project IP-2016-06-9782 and the University of Rijeka Project 13.12.1.3.02, by the DFG Collaborative Research Centers SFB823/C4 and SFB876/C3, the Polish National Research Centre grant UMO-2016/22/M/ST9/00382, and by the Brazilian MCTIC, CNPq and FAPERJ. E.P. has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska–Curie grant agreement No. 664931. M.C. has received financial support through the Postdoctoral Junior Leader Fellowship Programme from la Caixa Banking Foundation, grant No. LCF/BQ/LI18/11630012.
Published: 2020

45. MAGIC observations of the diffuse γ -ray emission in the vicinity of the Galactic center

Author: U. Barres de Almeida, L. Nogués, Damir Lelas, Dorota Sobczyńska, Daniel Kerszberg, Zeljka Bosnjak, Satoshi Masuda, L. Maraschi, Elina Lindfors, M. Peresano, B. Banerjee, D. Strom, A. Rugliancich, Marina Manganaro, D. Zarić, Daniel Mazin, D. Dominis Prester, Shunsuke Sakurai, Kyoshi Nishijima, D. Fidalgo, Marc Ribó, I. Snidaric, S. Paiano, Pratik Majumdar, M. V. Fonseca, Giacomo Bonnoli, Martin Will, Karl Mannheim, Ivica Puljak, Seiya Nozaki, Juan Abel Barrio, M. Nöthe, Narek Sahakyan, Toshiaki Inada, Hidetoshi Kubo, G. Busetto, Konstancja Satalecka, Michele Doro, E. Molina, Pablo Peñil, P. Munar-Adrover, E. Colombo, Saša Mićanović, John Hoang, V. Fallah Ramazani, Lab Saha, T. Schweizer, Luca Foffano, K. Noda, Daniel Morcuende, Jose Luis Contreras, M. Palatiello, V. Vitale, J. Becerra González, Juan Cortina, Stefano Covino, Francesco Dazzi, A. Fernández-Barral, Alice Donini, L. A. Antonelli, D. Ninci, Sanae Inoue, U. Colin, Manuela Mallamaci, D. Hadasch, Alessio Berti, Kai Phillip Schmidt, Sidika Merve Colak, David A. Green, Alexander Hahn, Wrijupan Bhattacharyya, Jordi Delgado, Tomoki Saito, Giovanni Ceribella, J. van Scherpenberg, A. Arbet Engels, Léa Jouvin, Sargis Gasparyan, Fabrizio Tavecchio, A. Somero, F. Di Pierro, Lluis Font, Stefano Ansoldi, Manuel Delfino, I. Vovk, B. Machado de Oliveira Fraga, Vitaly Neustroev, Davide Depaoli, Riccardo Paoletti, Wolfgang Rhode, M. Strzys, David Paneque, D. Miceli, Mosè Mariotti, Yuki Iwamura, A. López-Oramas, P. G. Prada Moroni, N. Giglietto, Valerio Vagelli, Chiara Righi, G. Ferrara, J. Palacio, D. Guberman, Ana Babić, Nikola Godinovic, Luca Tosti, Ferdinando Giordano, P. Temnikov, Alicia Fattorini, R. J. García López, J. M. Paredes, Antonio Stamerra, Junko Kushida, P. Da Vela, M. I. Martínez, Serena Loporchio, Satoshi Fukami, G. Maneva, Jürgen Besenrieder, Christian Fruck, Camilla Maggio, Daniela Dorner, D. Elsaesser, Gaia Vanzo, V. A. Acciari, Massimo Persic, F. Leone, V. D'Elia, Kari Nilsson, M. Gaug, Adrian Biland, Masahiro Teshima, Saverio Lombardi, J. Herrera, Julian Sitarek, Cosimo Nigro, Elisa Bernardini, J. Rico, Dario Hrupec, M. A. Lopez, Mitsunari Takahashi, A. Chilingaryan, Dominik Baack, E. Do Souto Espiñeira, Tomislav Terzić, A. De Angelis, Yusuke Suda, Carlo Vigorito, Moritz Hütten, Abelardo Moralejo, E. Moretti, M. Minev, B. De Lotto, Ciro Bigongiari, M. Garczarczyk, R. López-Coto, Kazuma Ishio, Elisa Prandini, Rodolfo Carosi, R. Mirzoyan, Yating Chai, Stefan Cikota, M. Vazquez Acosta, Victoria Moreno, Francesco Longo, Lorenzo Bellizzi, Martin Makariev, Oscar Blanch, T. Surić, Shimpei Tsujimoto, Wlodek Bednarek, N. Torres-Albà, Jose Miguel Miranda, Alessandra Lamastra, L. Di Venere, Federal Ministry of Education and Research (Germany), Istituto Nazionale di Fisica Nucleare, Istituto Nazionale di Astrofisica, Swiss National Science Foundation, Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Department of Atomic Energy (India), Japan Society for the Promotion of Science, Ministry of Education, Youth and Science (Bulgaria), Academy of Finland, Universidad de Barcelona, Croatian Science Foundation, University of Rijeka, Polish National Agency for Academic Exchange, Ministério da Ciência e Tecnologia (Brasil), Acciari, V. A., Ansoldi, S., Antonelli, L. A., Arbet Engels, A., Baack, D., Babic, A., Banerjee, B., Barres De Almeida, U., Barrio, J. A., Becerra Gonzalez, J., Bednarek, W., Bellizzi, L., Bernardini, E., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bonnoli, G., Bosnjak, Z., Busetto, G., Carosi, R., Ceribella, G., Chai, Y., Chilingaryan, A., Cikota, S., Colak, S. M., Colin, U., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D'Elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Delfino, M., Delgado, J., Depaoli, D., Di Pierro, F., Di Venere, L., Do Souto Espineira, E., Dominis Prester, D., Donini, A., Dorner, D., Doro, M., Elsaesser, D., Fallah Ramazani, V., Fattorini, A., Fernandez-Barral, A., Ferrara, G., Fidalgo, D., Foffano, L., Fonseca, M. V., Font, L., Fruck, C., Fukami, S., Garcia Lopez, R. J., Garczarczyk, M., Gasparyan, S., Gaug, M., Giglietto, N., Giordano, F., Godinovic, N., Green, D., Guberman, D., Hadasch, D., Hahn, A., Herrera, J., Hoang, J., Hrupec, D., Hutten, M., Inada, T., Inoue, S., Ishio, K., Iwamura, Y., Jouvin, L., Kerszberg, D., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Lombardi, S., Longo, F., Lopez, M., Lopez-Coto, R., Lopez-Oramas, A., Loporchio, S., Machado De Oliveira Fraga, B., Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martinez, M., Masuda, S., Mazin, D., Micanovic, S., Miceli, D., Minev, M., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Morcuende, D., Moreno, V., Moretti, E., Munar-Adrover, P., Neustroev, V., Nigro, C., Nilsson, K., Ninci, D., Nishijima, K., Noda, K., Nogues, L., Nothe, M., Nozaki, S., Paiano, S., Palacio, J., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Penil, P., Peresano, M., Persic, M., Prada Moroni, P. G., Prandini, E., Puljak, I., Rhode, W., Ribo, M., Rico, J., Righi, C., Rugliancich, A., Saha, L., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Schmidt, K., Schweizer, T., Sitarek, J., Snidaric, I., Sobczynska, D., Somero, A., Stamerra, A., Strom, D., Strzys, M., Suda, Y., Suric, T., Takahashi, M., Tavecchio, F., Temnikov, P., Terzic, T., Teshima, M., Torres-Alba, N., Tosti, L., Tsujimoto, S., Vagelli, V., Van Scherpenberg, J., Vanzo, G., Vazquez Acosta, M., Vigorito, C. F., Vitale, V., Vovk, I., Will, M., and Zaric, D.
Subjects: model [background], accelerator, Point source, Astrophysics::High Energy Astrophysical Phenomena, Gamma rays: general, background: model, general [Gamma rays], Cosmic ray, Astrophysics::Cosmology and Extragalactic Astrophysics, Astrophysics, programming, 01 natural sciences, Spectral line, law.invention, energy: threshold, law, gas, TRACER, 0103 physical sciences, ISM [Gamma rays], 010306 general physics, 010303 astronomy & astrophysics, Cosmic rays, Zenith, Astrophysics::Galaxy Astrophysics, Physics, Gamma rays: ISM, Galaxy: center, Galactic ridge, Galactic Center, Astronomy and Astrophysics, Particle accelerator, center [Galaxy], threshold [energy], MAGIC, gamma ray, Space and Planetary Science, cosmic radiation: galaxy, ddc:520, galaxy [cosmic radiation], Física nuclear, gamma rays: general, gamma rays: ISM, cosmic rays, Astrophysics - High Energy Astrophysical Phenomena
Abstract: [Aims] In the presence of a sufficient amount of target material, γ-rays can be used as a tracer in the search for sources of Galactic cosmic rays (CRs). Here we present deep observations of the Galactic center (GC) region with the MAGIC telescopes and use them to infer the underlying CR distribution and to study the alleged PeV proton accelerator at the center of our Galaxy., [Methods] We used data from ≈100 h observations of the GC region conducted with the MAGIC telescopes over five years (from 2012 to 2017). Those were collected at high zenith angles (58−70 deg), leading to a larger energy threshold, but also an increased effective collection area compared to low zenith observations. Using recently developed software tools, we derived the instrument response and background models required for extracting the diffuse emission in the region. We used existing measurements of the gas distribution in the GC region to derive the underlying distribution of CRs. We present a discussion of the associated biases and limitations of such an approach., [Results] We obtain a significant detection for all four model components used to fit our data (Sgr A*, “Arc”, G0.9+0.1, and an extended component for the Galactic Ridge). We observe no significant difference between the γ-ray spectra of the immediate GC surroundings, which we model as a point source (Sgr A*) and the Galactic Ridge. The latter can be described as a power-law with index 2 and an exponential cut-off at around 20 TeV with the significance of the cut-off being only 2σ. The derived cosmic-ray profile hints to a peak at the GC position and with a measured profile index of 1.2 ± 0.3 is consistent with the 1/r radial distance scaling law, which supports the hypothesis of a CR accelerator at the GC. We argue that the measurements of this profile are presently limited by our knowledge of the gas distribution in the GC vicinity., The financial support of the German BMBF and MPG, the Italian INFN and INAF, the Swiss National Fund SNF, the ERDF under the Spanish MINECO (FPA2015-69818-P, FPA2012-36668, FPA2015-68378-P, FPA2015-69210-C6-2-R, FPA2015-69210-C6-4-R, FPA2015-69210-C6-6-R, AYA2015-71042-P, AYA2016-76012-C3-1-P, ESP2015-71662-C2-2-P, FPA2017-90566-REDC), the Indian Department of Atomic Energy, the Japanese JSPS and MEXT, the Bulgarian Ministry of Education and Science, National RI Roadmap Project DO1-153/28.08.2018 and the Academy of Finland grant nr. 320045 is gratefully acknowledged. This work was also supported by the Spanish Centro de Excelencia “Severo Ochoa” SEV-2016-0588 and SEV-2015-0548, and Unidad de Excelencia “María de Maeztu” MDM-2014-0369, by the Croatian Science Foundation (HrZZ) Project IP-2016-06-9782 and the University of Rijeka Project 13.12.1.3.02, by the DFG Collaborative Research Centers SFB823/C4 and SFB876/C3, the Polish National Research Center grant UMO-2016/22/M/ST9/00382 and by the Brazilian MCTIC, CNPq and FAPERJ.
Published: 2020

46. Study of the variable broadband emission of Markarian 501 during the most extreme Swift X-ray activity

Author: Francesco Longo, Yuki Iwamura, Susumu Inoue, L. Nogués, M. I. Martínez, G. Pedaletti, Thomas Bretz, J. Buss, A. Rugliancich, Marina Manganaro, D. Galindo, Merja Tornikoski, Sabrina Einecke, Martin Makariev, Oscar Blanch, C. Leto, Ciro Bigongiari, Adrian Biland, D. Zarić, Andrii Neronov, M. Garczarczyk, Sargis Gasparyan, Konstancja Satalecka, Michele Doro, Marc Ribó, M. Noethe, J. Becerra González, Kazuma Ishio, J. Rico, Christian Fruck, Kyoshi Nishijima, Abelardo Moralejo, E. Moretti, Wolfgang Rhode, Christoph Wendel, Dominik Baack, Satoshi Masuda, Hidetoshi Kubo, Nikola Godinovic, B. Machado de Oliveira Fraga, Alexander Hahn, Manuel Delfino, Daniela Dorner, P. Giammaria, A. Niedzwiecki, Alessio Berti, U. Barres de Almeida, F. Verrecchia, G. Busetto, Lena Linhoff, D. Fidalgo, Damir Lelas, G. Ferrara, Alicia Fattorini, D. Hildebrand, David Paneque, V. A. Acciari, Bernd Schleicher, Gaia Vanzo, M. Peresano, Rodolfo Carosi, M. Perri, Alessandra Lamastra, John Hoang, Marcel Strzys, M. Gaug, Chiara Righi, M. Armas Padilla, D. Ninci, Ana Babić, Michael Blank, Dorota Sobczyńska, D. Dominis Prester, A. De Angelis, Vitaly Neustroev, I. Snidaric, F. Schulz, E. von Willert, D. Guberman, A. Y. Lien, J. Herrera, Juan Abel Barrio, B. Banerjee, J. van Scherpenberg, V. D'Elia, Narek Sahakyan, P. Temnikov, Stefano Ansoldi, R. J. García López, G. Maneva, E. Do Souto Espiñera, B. De Lotto, Elisa Bernardini, Riccardo Paoletti, S. Paiano, Karl Mannheim, Pablo Peñil, A. Shukla, Ivica Puljak, Jose Luis Contreras, D. Neise, Andrea Tramacere, Manuela Mallamaci, A. López-Oramas, Jordi Delgado, V. Fallah Ramazani, Juan Cortina, J. Palacio, P. Colin, R. Walter, J. M. Paredes, F. Di Pierro, Antonio Stamerra, Pratik Majumdar, Camilla Maggio, M. V. Fonseca, Ievgen Vovk, Francesco Dazzi, A. Fernández-Barral, Cosimo Nigro, P. Munar-Adrover, Massimo Persic, Dario Hrupec, L. A. Antonelli, Martin Will, D. Kuveždić, T. Schweizer, F. Leone, Anne Lähteenmäki, Tarek M. Hassan, Fabrizio Tavecchio, Masahiro Teshima, A. Somero, Kari Nilsson, Ll. Font, M. Bulinski, Wlodek Bednarek, Vitalii Sliusar, P. G. Prada Moroni, Junko Kushida, P. Da Vela, E. Prandini, N. Torres-Albà, Joni Tammi, Sebastian Achim Mueller, J. R. Garcia, Giacomo Bonnoli, Manuel Doerr, Stefano Gallozzi, Jose Miguel Miranda, Wrijupan Bhattacharyya, Julian Sitarek, T. Surić, Shimpei Tsujimoto, K. Bruegge, D. Elsaesser, Tomislav Terzić, Jürgen Besenrieder, E. Molina, E. Colombo, Lab Saha, Luca Foffano, Mosè Mariotti, A. Paravac, Saverio Lombardi, M. Nievas Rosillo, M. Minev, M. Balbo, D. Hadasch, R. Mirzoyan, A. Arbet-Engels, K. Sedlaczek, L. Maraschi, Elina Lindfors, Daniel Mazin, Stefan Cikota, M. Vazquez Acosta, Victoria Moreno, Stefano Covino, Tomoki Saito, Giovanni Ceribella, Aaron Dominguez, K. Noda, Sidika Merve Colak, M. López, German Research Foundation, Istituto Nazionale di Fisica Nucleare, Istituto Nazionale di Astrofisica, Swiss National Science Foundation, Japan Society for the Promotion of Science, Ministry of Education, Culture, Sports, Science and Technology (Japan), Croatian Science Foundation, University of Rijeka, Polish National Agency for Academic Exchange, Ministério da Ciência, Tecnologia e Inovação (Brasil), National Aeronautics and Space Administration (US), Department of Energy (US), Commissariat à l'Ènergie Atomique et aux Ènergies Alternatives (France), Centre National de la Recherche Scientifique (France), Institut National de Physique Nucléaire et de Physique des Particules (France), Agenzia Spaziale Italiana, High Energy Accelerator Research Organization (Japan), Japan Aerospace Exploration Agency, Knut and Alice Wallenberg Foundation, Swedish Research Council, Swedish National Space Board, Acciari, V. A., Ansoldi, S., Antonelli, L. A., Babic, A., Banerjee, B., Barres De Almeida, U., Barrio, J. A., Becerra Gonzalez, J., Bednarek, W., Bernardini, E., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Blanch, O., Bonnoli, G., Busetto, G., Carosi, R., Ceribella, G., Cikota, S., Colak, S. M., Colin, P., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D'Elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Delfino, M., Delgado, J., DI Pierro, F., Do Souto Espinera, E., Dominguez, A., Dominis Prester, D., Doro, M., Fallah Ramazani, V., Fattorini, A., Fernandez-Barral, A., Ferrara, G., Fidalgo, D., Foffano, L., Fonseca, M. V., Font, L., Fruck, C., Galindo, D., Gallozzi, S., Garcia Lopez, R. J., Garczarczyk, M., Gasparyan, S., Gaug, M., Giammaria, P., Godinovic, N., Guberman, D., Hadasch, D., Hahn, A., Hassan, T., Herrera, J., Hoang, J., Hrupec, D., Inoue, S., Ishio, K., Iwamura, Y., Kubo, H., Kushida, J., Kuvecdic, D., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Lombardi, S., Longo, F., Lopez, M., Lopez-Oramas, A., MacHado De Oliveira Fraga, B., Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Maraschi, L., Mariotti, M., Martinez, M., Masuda, S., Mazin, D., Minev, M., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Moreno, V., Moretti, E., Munar-Adrover, P., Neustroev, V., Niedzwiecki, A., Nievas Rosillo, M., Nigro, C., Nilsson, K., Ninci, D., Nishijima, K., Noda, K., Nogues, L., Paiano, S., Palacio, J., Paneque, D., Paoletti, R., Paredes, J. M., Pedaletti, G., Penil, P., Peresano, M., Persic, M., Prada Moroni, P. G., Prandini, E., Puljak, I., Garcia, J. R., Ribo, M., Rico, J., Righi, C., Rugliancich, A., Saha, L., Sahakyan, N., Saito, T., Satalecka, K., Schweizer, T., Sitarek, J., Snidaric, I., Sobczynska, D., Somero, A., Stamerra, A., Strzys, M., Suric, T., Tavecchio, F., Temnikov, P., Terzic, T., Teshima, M., Torres-Alba, N., Tsujimoto, S., Van Scherpenberg, J., Vanzo, G., Vazquez Acosta, M., Vovk, I., Will, M., Zaric, D., Arbet-Engels, A., Baack, D., Balbo, M., Biland, A., Blank, M., Bretz, T., Bruegge, K., Bulinski, M., Buss, J., Doerr, M., Dorner, D., Einecke, S., Elsaesser, D., Hildebrand, D., Linhoff, L., Mannheim, K., Mueller, S., Neise, D., Neronov, A., Noethe, M., Paravac, A., Rhode, W., Schleicher, B., Schulz, F., Sedlaczek, K., Shukla, A., Sliusar, V., Von Willert, E., Walter, R., Wendel, C., Tramacere, A., Lien, A., Perri, M., Verrecchia, F., Armas Padilla, M., Leto, C., Lahteenmaki, A., Tornikoski, M., Tammi, J., Department of Electronics and Nanoengineering, Metsähovi Radio Observatory, Aalto-yliopisto, and Aalto University
Subjects: galaxies: active, BL Lacertae objects: individual: Mrk 501, gamma rays: galaxies, X-rays: galaxies, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Flux, Context (language use), Astrophysics::Cosmology and Extragalactic Astrophysics, Astrophysics, 01 natural sciences, Power law, Spectral line, Galaxies: active, Gamma rays: galaxies, individual: Mrk 501 [BL Lacertae objects], 0103 physical sciences, MAGIC (telescope), Blazar, 010303 astronomy & astrophysics, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, galaxie [Gamma rays], 010308 nuclear & particles physics, Gamma ray, Astronomy and Astrophysics, galaxies [X-rays], Crab Nebula, Space and Planetary Science, active [galaxies], galaxies [gamma rays], ddc:520, Física nuclear, High Energy Astrophysical Phenomena, Astrophysics - High Energy Astrophysical Phenomena
Abstract: [Context] Markarian 501 (Mrk 501) is a very high-energy (VHE) gamma-ray blazar located at z = 0:034, which is regularly monitored by a wide range of multi-wavelength instruments, from radio to VHE gamma rays. During a period of almost two weeks in July 2014, the highest X-ray activity of Mrk 501 was observed in -14 years of operation of the Neil Gehrels Swift Gamma-ray Burst Observatory., [Aims] We characterize the broadband variability of Mrk 501 from radio to VHE gamma rays during the most extreme X-ray activity measured in the last 14 years, and evaluate whether it can be interpreted within theoretical scenarios widely used to explain the broadband emission from blazars., [Methods] The emission of Mrk 501 was measured at radio with Metsähovi, at optical–UV with KVA and Swift/UVOT, at X-ray with Swift/XRT and Swift/BAT, at gamma ray with Fermi-LAT, and at VHE gamma rays with the FACT and MAGIC telescopes. The multi-band variability and correlations were quantified, and the broadband spectral energy distributions (SEDs) were compared with predictions from theoretical models., [Results] The VHE emission of Mrk 501 was found to be elevated during the X-ray outburst, with a gamma-ray flux above 0.15 TeV varying from ∼0.5 to ∼2 times the Crab nebula flux. The X-ray and VHE emission both varied on timescales of 1 day and were found to be correlated. We measured a general increase in the fractional variability with energy, with the VHE variability being twice as large as the X-ray variability. The temporal evolution of the most prominent and variable segments of the SED, characterized on a day-by-day basis from 2014 July 16 to 2014 July 31, is described with a one-zone synchrotron self-Compton model with variations in the break energy of the electron energy distribution (EED), and with some adjustments in the magnetic field strength and spectral shape of the EED. These results suggest that the main flux variations during this extreme X-ray outburst are produced by the acceleration and the cooling of the high-energy electrons. A narrow feature at ∼3 TeV was observed in the VHE spectrum measured on 2014 July 19 (MJD 56857.98), which is the day with the highest X-ray flux (>0.3 keV) measured during the entire Swift mission. This feature is inconsistent with the classical analytic functions to describe the measured VHE spectra (power law, log-parabola, and log-parabola with exponential cutoff) at more than 3σ. A fit with a log-parabola plus a narrow component is preferred over the fit with a single log-parabola at more than 4σ, and a dedicated Monte Carlo simulation estimated the significance of this extra component to be larger than 3σ. Under the assumption that this VHE spectral feature is real, we show that it can be reproduced with three distinct theoretical scenarios: (a) a pileup in the EED due to stochastic acceleration; (b) a structured jet with two-SSC emitting regions, with one region dominated by an extremely narrow EED; and (c) an emission from an IC pair cascade induced by electrons accelerated in a magnetospheric vacuum gap, in addition to the SSC emission from a more conventional region along the jet of Mrk 501., The financial support of the German BMBF and MPG, the Italian INFN and INAF, the Swiss National Fund SNF, the ERDF under the Spanish MINECO (FPA2015-69818-P, FPA2012-36668, FPA2015-68378-P, FPA2015-69210-C6-2-R, FPA2015-69210-C6-4-R, FPA2015-69210-C6-6-R, AYA2015-71042-P, AYA2016-76012-C3-1-P, ESP2015-71662-C2-2-P, FPA2017-90566-REDC), and the Japanese JSPS and MEXT is gratefully acknowledged. This work was also supported by the Spanish Centro de Excelencia “Severo Ochoa” SEV-2016-0588 and SEV-2015-0548, and Unidad de Excelencia “María de Maeztu” MDM-2014-0369, by the Croatian Science Foundation (HrZZ) Project IP-2016-06-9782 and the University of Rijeka Project 13.12.1.3.02, by the DFG Collaborative Research Centers SFB823/C4 and SFB876/C3, the Polish National Research Centre grant UMO-2016/22/M/ST9/00382 and by the Brazilian MCTIC, CNPq and FAPERJ. The Fermi-LAT Collaboration acknowledges generous ongoing support from a number of agencies and institutes that have supported both the development and the operation of the LAT as well as scientific data analysis. These include the National Aeronautics and Space Administration and the Department of Energy in the United States, the Commissariat à l’Energie Atomique and the Centre National de la Recherche Scientifique/Institut National de Physique Nucléaire et de Physique des Particules in France, the Agenzia Spaziale Italiana and the Istituto Nazionale di Fisica Nucleare in Italy, the Ministry of Education, Culture, Sports, Science and Technology (MEXT), High Energy Accelerator Research Organization (KEK) and Japan Aerospace Exploration Agency (JAXA) in Japan, and the K. A. Wallenberg Foundation, the Swedish Research Council and the Swedish National Space Board in Sweden. Additional support for science analysis during the operations phase is gratefully acknowledged from the Instituto Nazionale di Astrofisica in Italy and the Centre National d’Études Spatiales in France. The important contributions from ETH Zurich grants ETH-10.08-2 and ETH-27.12-1 as well as the funding by the Swiss SNF and the German BMBF (Ver-bundforschung Astro-und Astroteilchenphysik) and HAP (Helmoltz Alliance for Astroparticle Physics) are gratefully acknowledged. Part of this work is supported by Deutsche Forschungsgemeinschaft (DFG) within the Collaborative Research Center SFB 876, project C3. We thank the Instituto de Astrofisica de Canarias for allowing us to operate the telescope at the Observatorio del Roque de los Muchachos in La Palma, the Max-Planck-Institut fur Physik for providing us with the mount of the former HEGRA CT3 telescope, and the MAGIC Collaboration for their support. JBG acknowledges the support of the Viera y Clavijo program funded by ACIISI and ULL. C. W. is grateful for the support by the project “Promotion inklusive” of the Universität zu Köln and the German Bundesmin-isterium für Arbeit und Soziales. This publication makes use of data obtained at Metsähovi Radio Observatory, operated by Aalto University, Finland.
Published: 2020

47. A search for dark matter in Triangulum II with the MAGIC telescopes

Author: Satoshi Fukami, Alice Donini, F. Leone, Lorenzo Bellizzi, Wlodek Bednarek, Masahiro Teshima, M. Palatiello, N. Torres-Albà, Daniela Dorner, D. Dominis Prester, Pablo Peñil, Fabrizio Tavecchio, Gaia Vanzo, Francesco Dazzi, Ll. Font, Kari Nilsson, V. Vitale, Valerio Vagelli, Nikola Godinovic, Jose Miguel Miranda, E. Prandini, Christian Fruck, G. Busetto, Yating Chai, D. Miceli, V. Fallah Ramazani, Stefan Cikota, Jordi Delgado, Pawel Gliwny, M. Vazquez Acosta, M. Gaug, A. Somero, G. Ferrara, Manuel Delfino, D. Zarić, Victoria Moreno, L. Nogués, Jarred Gershon Green, Adrian Biland, Cosimo Nigro, F. Di Pierro, Ž. Bošnjak, J. Herrera, Giacomo Bonnoli, D. Ninci, P. G. Prada Moroni, E. Molina, Francesco Longo, John Hoang, Chiara Righi, E. Colombo, Ana Babić, Serena Loporchio, D. Fidalgo, I. Snidaric, Lab Saha, Luca Foffano, Razmik Mirzoyan, U. Barres de Almeida, J. van Scherpenberg, Elisa Bernardini, Stefano Ansoldi, Tjark Miener, David Paneque, U. Colin, David A. Green, J. Kushida, V. D'Elia, Daniel Morcuende, Jose Luis Contreras, Juan Cortina, P. Temnikov, Alexander Hahn, Juan Abel Barrio, J. Rico, Riccardo Paoletti, Alessandra Lamastra, L. Di Venere, M. Peresano, D. Guberman, Narek Sahakyan, Damir Lelas, Francesco Gabriele Saturni, Dorota Sobczyńska, Léa Jouvin, B. De Lotto, S. Nozaki, Stefano Covino, B. Banerjee, Wrijupan Bhattacharyya, Shunsuke Sakurai, D. Strom, Kai Phillip Schmidt, K. Noda, P. Da Vela, J. Palacio, Martin Makariev, E. Do Souto Espiñeira, Tomislav Terzić, Ivica Puljak, Oscar Blanch, Dario Hrupec, Sidika Merve Colak, D. Hadasch, Davide Depaoli, M. A. Lopez, J. Becerra González, D. Elsaesser, J. M. Paredes, Antonio Stamerra, Mitsunari Takahashi, P. Munar-Adrover, Victor A. Acciari, Abelardo Moralejo, Ievgen Vovk, Camilla Maggio, E. Moretti, Pratik Majumdar, M. V. Fonseca, Mosè Mariotti, Moritz Hütten, Julian Sitarek, A. Arbet Engels, A. De Angelis, Vitaly Neustroev, Sargis Gasparyan, Yuki Iwamura, Martin Will, A. Rugliancich, Marina Manganaro, Saverio Lombardi, A. López-Oramas, Susumu Inoue, Alessio Berti, Luca Tosti, S. Mićanović, K. Nishijima, L. A. Antonelli, Jürgen Besenrieder, T. Schweizer, M. Minev, Ferdinando Giordano, Toshiaki Inada, Wolfgang Rhode, Konstancja Satalecka, Manuela Mallamaci, G. Maneva, Michele Doro, Yusuke Suda, Carlo Vigorito, Ciro Bigongiari, T. Surić, S. Paiano, M. Garczarczyk, Karl Mannheim, R. López-Coto, Daniel Kerszberg, Tomoki Saito, Giovanni Ceribella, Kazuma Ishio, Rodolfo Carosi, Dominik Baack, Ashot Chilingarian, L. Maraschi, Elina Lindfors, Marc Ribó, Daniel Mazin, Hidetoshi Kubo, Alicia Fattorini, M. I. Martínez, B. Machado de Oliveira Fraga, N. Giglietto, R. J. García López, Massimo Persic, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Ministerio de Economía y Competitividad (España), Acciari, V. A., Ansoldi, S., Antonelli, L. A., Arbet Engels, A., Baack, D., Babic, A., Banerjee, B., Barres de Almeida, U., Barrio, J. A., Becerra Gonzalez, J., Bednarek, W., Bellizzi, L., Bernardini, E., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bonnoli, G., Bosnjak, Z., Busetto, G., Carosi, R., Ceribella, G., Chai, Y., Chilingarian, A., Cikota, S., Colak, S. M., Colin, U., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D'Elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Delfino, M., Delgado, J., Depaoli, D., Di Pierro, F., Di Venere, L., Do Souto Espineira, E., Dominis Prester, D., Donini, A., Dorner, D., Doro, M., Elsaesser, D., Fallah Ramazani, V., Fattorini, A., Ferrara, G., Fidalgo, D., Foffano, L., Fonseca, M. V., Font, L., Fruck, C., Fukami, S., Garcia Lopez, R. J., Garczarczyk, M., Gasparyan, S., Gaug, M., Giglietto, N., Giordano, F., Gliwny, P., Godinovic, N., Green, D., Green, J. G., Guberman, D., Hadasch, D., Hahn, A., Herrera, J., Hoang, J., Hrupec, D., Hutten, M., Inada, T., Inoue, S., Ishio, K., Iwamura, Y., Jouvin, L., Kerszberg, D., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Lombardi, S., Longo, F., Lopez, M., Lopez-Coto, R., Lopez-Oramas, A., Loporchio, S., Machado de Oliveira Fraga, B., Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martinez, M., Mazin, D., Micanovic, S., Miceli, D., Miener, T., Minev, M., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Morcuende, D., Moreno, V., Moretti, E., Munar-Adrover, P., Neustroev, V., Nigro, C., Nilsson, K., Ninci, D., Nishijima, K., Noda, K., Nogues, L., Nozaki, S., Paiano, S., Palacio, J., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Penil, P., Peresano, M., Persic, M., Prada Moroni, P. G., Prandini, E., Puljak, I., Rhode, W., Ribo, M., Rico, J., Righi, C., Rugliancich, A., Saha, L., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Saturni, F. G., Schmidt, K., Schweizer, T., Sitarek, J., Snidaric, I., Sobczynska, D., Somero, A., Stamerra, A., Strom, D., Suda, Y., Suric, T., Takahashi, M., Tavecchio, F., Temnikov, P., Terzic, T., Teshima, M., Torres-Alba, N., Tosti, L., Vagelli, V., van Scherpenberg, J., Vanzo, G., Vazquez Acosta, M., Vigorito, C. F., Vitale, V., Vovk, I., Will, M., and Zaric, D.
Subjects: Dwarf spheroidal satellite galaxies, Astrophysics, 7. Clean energy, 01 natural sciences, dark matter [WIMP], Imaging air Cherenkov telescopes, High Energy Physics - Phenomenology (hep-ph), WIMP, Dwarf spheroidal satellite galaxie, flux [gamma ray], Triangulum II, annihilation [WIMP], 010303 astronomy & astrophysics, Physics, astro-ph.HE, High Energy Astrophysical Phenomena (astro-ph.HE), Annihilation, scaling, density [dark matter], hep-ph, halo [dark matter], High Energy Physics - Phenomenology, Dark matter, Indirect searches, kinematics, Física nuclear, Halo, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics and Astronomy, Milky Way, satellite, FOS: Physical sciences, Astrophysics::Cosmology and Extragalactic Astrophysics, GeneralLiterature_MISCELLANEOUS, VHE, annihilation [down], 0103 physical sciences, Imaging air Cherenkov telescope, Indirect searche, ddc:530, Astrophysics::Galaxy Astrophysics, Particle Physics - Phenomenology, Triangulum, 010308 nuclear & particles physics, ComputingMilieux_PERSONALCOMPUTING, Astronomy and Astrophysics, MAGIC, Galaxy, Dark matter halo, annihilation [cross section], Space and Planetary Science, galaxy
Abstract: MAGIC Collaboration: et al., arXiv:2003.05260v1, We present the first results from very-high-energy observations of the dwarf spheroidal satellite candidate Triangulum II with the MAGIC telescopes from 62.4 hours of good-quality data taken between August 2016 and August 2017. We find no gamma-ray excess in the direction of Triangulum II, and upper limits on both the differential and integral gamma-ray flux are presented. Currently, the kinematics of Triangulum II are affected by large uncertainties leading to a bias in the determination of the properties of its dark matter halo. Using a scaling relation between the annihilation J -factor and heliocentric distance of well-known dwarf spheroidal galaxies, we estimate an annihilation J -factor for Triangulum II for WIMP dark matter of log[Jann(0.5◦)/ GeV2cm−5] = 19.35±0.37. We also derive a dark matter density profile for the object relying on results from resolved simulations of Milky Way sized dark matter halos. We obtain 95% confidence-level limits on the thermally averaged annihilation cross section for WIMP annihilation into various Standard Model channels. The most stringent limits are obtained in the τ−τ+final state, where a cross section for annihilation down to hσannvi = 3.05 × 10−24cm3s−1is excluded., The financial support of the German BMBF and MPG, Germany, the Italian INFN and INAF, Italy, the Swiss National Fund SNF, the ERDF under the Spanish MINECO (FPA2017-87859-P, FPA2017-85668-P, FPA2017-82729-C6-2-R, FPA2017-82729-C6-6-R, FPA2017-82729-C6-5-R, AYA2015-71042-P, AYA2016-76012-C3-1-P, ESP2017-87055-C2-2-P, FPA2017-90566-REDC), the Indian Department of Atomic Energy, the Japanese JSPS, Japan and MEXT, Japan, the Bulgarian Ministry of Education and Science, National RI Roadmap Project DO1-153/28.08.2018 and the Academy of Finland grant nr. 320045 is gratefully acknowledged. This work was also supported by the Spanish Centro de Excelencia “Severo Ochoa” SEV-2016-0588 and SEV-2015-0548, and Unidad de Excelencia “María de Maeztu” MDM-2014-0369, by the Croatian Science Foundation (HrZZ) Project IP-2016-06-9782 and the University of Rijeka, Croatia Project 13.12.1.3.02, by the DFG, Germany Collaborative Research Centers SFB823/C4 and SFB876/C3, the Polish National Research Centre, Polland grant UMO-2016/22/M/ST9/00382 and by the Brazilian MCTIC, CNPq, Brazil and FAPERJ, Brazil .
Published: 2020

48. Targeting the 'Cytokine Storm' for therapeutic benefit

Author: Roman A. Lukaszewski, Graeme C. Clark, Kate Harrison, Riccardo V. D'Elia, and Petra C. F. Oyston
Subjects: Microbiology (medical), biology, medicine.medical_treatment, First line, Clinical Biochemistry, Immunology, Inflammation, biology.organism_classification, medicine.disease, Communicable Diseases, Virus, Cytokine, Immune system, medicine, Cytokines, Humans, Immunologic Factors, Immunology and Allergy, Minireview, medicine.symptom, Cytokine storm, Pathogen, Francisella tularensis
Abstract: Inflammation is the body's first line of defense against infection or injury, responding to challenges by activating innate and adaptive responses. Microbes have evolved a diverse range of strategies to avoid triggering inflammatory responses. However, some pathogens, such as the influenza virus and the Gram-negative bacteriumFrancisella tularensis, do trigger life-threatening “cytokine storms” in the host which can result in significant pathology and ultimately death. For these diseases, it has been proposed that downregulating inflammatory immune responses may improve outcome. We review some of the current candidates for treatment of cytokine storms which may prove useful in the clinic in the future and compare them to more traditional therapeutic candidates that target the pathogen rather than the host response.
Published: 2019

49. Histopathological and immunohistochemical characterization ofBurkholderia pseudomalleilesions in an acute model of infection with BALB/c mice

Author: Francisco J. Salguero, Riccardo V. D'Elia, and Waldo L. García-Jiménez
Subjects: Male, 0301 basic medicine, Pathology, medicine.medical_specialty, Burkholderia pseudomallei, Melioidosis, Neutrophils, T-Lymphocytes, 030106 microbiology, Pathology and Forensic Medicine, BALB/c, Pathogenesis, 03 medical and health sciences, Immune system, Antigen, Immunopathology, medicine, immunopathology, Animals, Lung, Molecular Biology, B-Lymphocytes, Mice, Inbred BALB C, biology, business.industry, Original Articles, Cell Biology, biology.organism_classification, medicine.disease, Disease Models, Animal, 030104 developmental biology, Burkholderia, Liver, immunohistochemistry, Original Article, business, Spleen
Abstract: Summary Organ tissue damage is a key contributor to host morbidity and mortality following infection with microbial agents. Severe immune responses, excessive cellular recruitment and necrosis of cells all play a role in disease pathology. Understanding the pathogenesis of disease can aid in identifying potential new therapeutic targets or simply act as a diagnostic tool. Burkholderia pseudomallei is a Gram‐negative bacterium that can cause acute and chronic diseases. The BALB/c mouse has been shown to be highly susceptible to aerosol challenge with B. pseudomallei and hence acts as a good model to study the acute and potentially lethal form of the disease melioidosis. In our study, BALB/c mice were challenged and culled at predetermined time points to generate a pathological time course of infection. Lung, liver and spleen were subjected to pathological and immunohistochemical analysis. The number and type of microscopic lesions within each organ, as well as the location and the mean percentage of neutrophils, B cells, T cells and Burkholderia capsule antigen within the lesions, were all characterized during the time course. Neutrophils were determined as the key player in tissue pathology and generation of lesions, with B cells playing an insignificant role. This detailed pathological assessment increases our understanding of B. pseudomallei disease.
Published: 2017

50. Mitogen-activated protein kinases (MAPKs) are modulated during in vitro and in vivo infection with the intracellular bacterium Burkholderia pseudomallei

Author: R. J. Saint, Helen S. Atkins, Riccardo V. D'Elia, S. L. Newstead, and Graeme C. Clark
Subjects: 0301 basic medicine, Microbiology (medical), MAPK/ERK pathway, Burkholderia pseudomallei, Melioidosis, p38 mitogen-activated protein kinases, Biology, p38 Mitogen-Activated Protein Kinases, Cell Line, Microbiology, Mice, 03 medical and health sciences, In vivo, medicine, Animals, Extracellular Signal-Regulated MAP Kinases, Pathogen, Chemokine CCL2, Mice, Inbred BALB C, Tumor Necrosis Factor-alpha, Kinase, Macrophages, Diphenylamine, General Medicine, bacterial infections and mycoses, medicine.disease, biology.organism_classification, Enzyme Activation, 030104 developmental biology, Infectious Diseases, Benzamides, Immunology, bacteria, Female, Original Article, Tumor necrosis factor alpha
Abstract: Burkholderia pseudomallei is a Gram-negative intracellular bacterium that causes the disease melioidosis. The disease can be fatal if left untreated or when antibiotic therapy is delayed and total clearance of the pathogen from the host is often not accomplished with current therapies. Thus, new therapeutic approaches for the treatment of infections caused by B. pseudomallei are required. To better understand host responses to B. pseudomallei infection, the activation of key proteins involved in the TLR inflammatory cascade was measured by western blotting. Activation of the mitogen-activated protein kinases (MAPKs) p38 and ERK were both significantly altered during both in vitro and in vivo infection. In considering an approach for therapy of B. pseudomallei infection the inhibition of ERK was achieved in vitro using the inhibitor PD0325901, along with decreased TNF-α production. However, the reduction in phosphorylated ERK and TNF-α release did not correspond with decreased bacterial replication or enhance clearance from infected macrophages. Despite this apparent lack of effect on the intracellular growth of B. pseudomallei in vitro, it is not clear what effect inhibition of ERK activation might have on outcome of disease in vivo. It may be that decreasing the levels of TNF-α in vivo could aid in reducing the overactive immune response that is known to ensue following B. pseudomallei infection, thereby increasing host survival.
Published: 2017

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