1. Quality of life and treatment satisfaction in adults with Type 1 diabetes: a comparison between continuous subcutaneous insulin infusion and multiple daily injections
- Author
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A. Nicolucci, A. Maione, M. Franciosi, R. Amoretti, E. Busetto, F. Capani, D. Bruttomesso, P. Di Bartolo, A. Girelli, F. Leonetti, L. Morviducci, P. Ponzi, E. Vitacolonna, L. V. Cassano, N. Tota, V. Cherubini, A. Iannilli A. Corsi, P. Ponzani, V. Montani, P. Di Berardino, M. Velussi, F. Giorgino, V. Gigantelli, G. Beltramello, A. Pianta, R. Trevisan, G. Lepore, G. Forlani, G. Marchesini, D. Crazzolara, M. Marchesi, E. Zarra, B. Agosti, G. Careddu, L. Tomaselli, R. Vigneri, M. Agrusta, V. Di Blasi, S. Tumini, M. T. Anzellotti, P. Ruggeri, P. Foglini, M. Rossana, A Murri, S. Toni, M. F. Reali, M. Nizzoli, S. Aquati, G. d’Annunzio, N. Minuto, L. Cataldi, C. Bordone, R. Iannarelli, F. Sciarretta, M. Tagliaferri, M. A. Lezzi, L. Sciangula, A. Ciucci, M. Bonomo, E. Meneghini, G. Mariani, P. Colapinto, G. Testori, P. Rampini, R. Bonfanti, F. Meschi, G. Galimberti, A. Laurenzi, A. Veronelli, C. Mauri, C. Tortul, A. M. Cernigoi, M. E. De Feo, M. Piscopo, G. Annuzzi, L. Bozzetto, A. Franzese, P. Buono, S. Turco, A. Turco, F. Prisco, D. Iafusco, M. Trovati, P. Massucco, S. Costa, M, V. Provenzano, L. Strazzera, G. Ridola, E. Torlone, M. Orsini Federici, A. Bertolotto, M. Aragona, F. Pellicano, V. Manicardi, M. Michelini, M. Parenti, A. C. Babini, P. Borboni, A. Di Flaviani, M. L. Manca Bitti, S. Piccinini, A. Clementi, C. Tubili, C. Suraci, S. Carletti, A. Moretti, M. Maiello, V. C. Iannucci, N. Sulli, B. Shashaj, D. Fava, F. Massimiani, P. Pozzilli, S. Manfrini, C. Landi, I. Tanganelli, G. Grassi, M. Tomelini, R. De Luca, L. Corgiat Mansin, R. Candido, E. Manca, L. Tonutti, C. Noacco, I. Franzetti, P. Marnini., Nicolucci, A., Maione, A., Franciosi, M., Amoretti, R., Busetto, E., Capani, F., Bruttomesso, D., Di Bartolo, P., Girelli, A., Leonetti, F., Morviducci, L., Ponzi, P., Vitacolonna, E., Cassano, L. V., Tota, N., Cherubini, V., Corsi, A. Iannilli A., Ponzani, P., Montani, V., Di Berardino, P., Velussi, M., Giorgino, F., Gigantelli, V., Beltramello, G., Pianta, A., Trevisan, R., Lepore, G., Forlani, G., Marchesini, G., Crazzolara, D., Marchesi, M., Zarra, E., Agosti, B., Careddu, G., Tomaselli, L., Vigneri, R., Agrusta, M., Di Blasi, V., Tumini, S., Anzellotti, M. T., Ruggeri, P., Foglini, P., Rossana, M., Murri, A, Toni, S., Reali, M. F., Nizzoli, M., Aquati, S., D’Annunzio, G., Minuto, N., Cataldi, L., Bordone, C., Iannarelli, R., Sciarretta, F., Tagliaferri, M., Lezzi, M. A., Sciangula, L., Ciucci, A., Bonomo, M., Meneghini, E., Mariani, G., Colapinto, P., Testori, G., Rampini, P., Bonfanti, R., Meschi, F., Galimberti, G., Laurenzi, A., Veronelli, A., Mauri, C., Tortul, C., Cernigoi, A. M., De Feo, M. E., Piscopo, M., Annuzzi, G., Bozzetto, L., Franzese, A., Buono, P., Turco, S., Turco, A., Prisco, F., Iafusco, D., Trovati, M., Massucco, P., Costa, S., M, Provenzano, V., Strazzera, L., Ridola, G., Torlone, E., Orsini Federici, M., Bertolotto, A., Aragona, M., Pellicano, F., Manicardi, V., Michelini, M., Parenti, M., Babini, A. C., Borboni, P., Di Flaviani, A., Manca Bitti, M. L., Piccinini, S., Clementi, A., Tubili, C., Suraci, C., Carletti, S., Moretti, A., Maiello, M., Iannucci, V. C., Sulli, N., Shashaj, B., Fava, D., Massimiani, F., Pozzilli, P., Manfrini, S., Landi, C., Tanganelli, I., Grassi, G., Tomelini, M., De Luca, R., Corgiat Mansin, L., Candido, R., Manca, E., Tonutti, L., Noacco, C., Franzetti, I., and Marnini., P.
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multiple daily injections ,Insulin pump ,Adult ,Male ,medicine.medical_specialty ,Continuous subcutaneous insulin infusion ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Injections, Subcutaneous ,Insulin Glargine ,Endocrinology ,Patient satisfaction ,Insulin Infusion Systems ,Quality of life ,Internal medicine ,Diabetes mellitus ,Internal Medicine ,medicine ,Humans ,Hypoglycemic Agents ,Insulin ,Multiple daily injection ,continuous subcutaneous insulin infusion ,quality of life ,questionnaires ,type 1 diabetes ,Type 1 diabetes ,Questionnaire ,Insulin glargine ,business.industry ,Middle Aged ,medicine.disease ,Obesity ,Surgery ,Insulin, Long-Acting ,Diabetes Mellitus, Type 1 ,Patient Satisfaction ,Quality of Life ,Female ,business ,Epidemiologic Methods ,medicine.drug - Abstract
Aims The aim of this case–control study was to compare quality of life (QoL) and treatment satisfaction in adults with Type 1 diabetes (T1DM) treated with either continuous subcutaneous insulin infusion (CSII) or multiple daily injections (MDI). Methods Consecutive patients aged between 18 and 55 years, and attending diabetes clinics for a routine visit, completed the Diabetes-Specific Quality-of-Life Scale (DSQOLS), the Diabetes Treatment Satisfaction Questionnaire (DTSQ) and the SF-36 Health Survey (SF-36). Case (CSII) and control subjects (MDI) were recruited in a 1 : 2 ratio. Results Overall, 1341 individuals were enrolled by 62 diabetes clinics; 481 were cases and 860 control subjects. Cases had a longer diabetes duration and were more likely to have eye and renal complications. Age, school education, occupation and HbA 1c were similar. Of control subjects, 90% followed glargine-based MDI regimens and 10% used NPH-based MDI regimens. On multivariate analysis, after adjusting for socioeconomic and clinical characteristics, scores in the following areas of the DSQOLS were higher in cases than control subjects: diet restrictions ( β = 5.96; P < 0.0001), daily hassles ( β = 3.57; P = 0.01) and fears about hypoglycaemia ( β = 3.88; P = 0.006). Treatment with CSII was also associated with a markedly higher DTSQ score ( β = 4.13; P < 0.0001) compared with MDI. Results were similar when CSII was compared separately with glargine- or NPH-based MDI regimens. Conclusions This large, non-randomized, case–control study suggests quality of life gains deriving from greater lifestyle flexibility, less fear of hypoglycaemia, and higher treatment satisfaction, when CSII is compared with either glargine-based or NPH-based MDI regimens. Diabet. Med. 25, 213–220 (2008)
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- 2008