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1. Adult B-cell acute lymphoblastic leukemias: Conclusions of the Russian prospective multicenter study ALL-2009

Author: E N Parovichnikova, V V Troitskaya, A N Sokolov, S N Bondarenko, O A Gavrilina, G A Baskhaeva, B V Biderman, I A Lukyanova, L A Kuz'mina, G A Klyasova, S K Kravchenko, E O Gribanova, E E Zvonkov, Z Kh Akhmerzaeva, O Yu Baranova, T S Kaporskaya, T V Ryltsova, E N Zotina, E E Zinina, O S Samoilova, K D Kaplanov, L V Gavrilova, T S Konstantinova, V A Lapin, A S Pristupa, A S Eluferyeva, T N Obukhova, I S Piskunova, I V Gal'tseva, V N Dvirnyk, M A Rusinov, S M Kulikov, and V G Savchenko
Subjects: acute ph-negative b-cell lymphoblastic leukemia, risk factors, cytogenetic abnormalities, Medicine
Abstract: Aim. To analyze the efficiency and reproducibility of the ALL-2009 protocol within the Russian prospective multicenter study based on different principles of cytostatic effects (non-intensive, but continuous cytotoxic treatment and a small number of allogeneic hematopoietic stem cells). Subjects and methods. The ALL-2009 (NCT01193933) study conducted in April 2009 to December 2016 included 194 patients (95 males and 99 females) aged 15 to 55 years (median age 28 years) with Ph-negative B-cell acute lymphoblastic leukemia (ALL). There was early pre-B-cell ALL in 54 patients, common ALL in 101, pre-B ALL in 39, initial leukocytosis in 9.4·109/l (0.4-899.0), lactate dehydrogenase in 901 IU (31-13 059), an initial central nervous system lesion in 17 (8.7%), mediastinal injury in 3 (1.5%), and splenomegaly in 111 (57.2%). The results of standard cytogenetic analysis are known in 113 (60.4%) patients. Normal karyotypes were detected in 49 (54.5%) out of the patients; t(4;11) in 9 (5.4%), t(1;19) in 2 (1.2%), and other karyotypic abnormalities in 53 (46.9%). Thirteen (7.8%) patients underwent allogeneic hematopoietic stem cell transplantation in first complete remission (CR); their proportion did not differ in the federal and regional centers. Results. The frequency of CR achievement was the same in the federal and regional centers and generally amounted to 87.5%. Early (8.8%) and CR (9.6%) mortality rates remained high despite the low aggressiveness of cytotoxic action, necessitating the improvement of auxiliary treatment. The five-year overall survival (OS) rates vary considerably in the federal and regional centers (72.6 and 43.8%), the relapse-free survival (RFS) (70.2 and 53.4%) and recurrence risk (23.1 and 36.5%) are comparable. This suggests that the non-intensive, but continuous exposure principle built in the ALL-2009 protocol makes it possible to reproduce the envisaged treatment program and to achieve satisfactory results. Conclusion. The ALL-2009 protocol allows both the federal and regional centers to obtain the long-term results comparable with those of current foreign studies: OS (54.2%), RFS (56.5%); and relapse risk (35.4%). Multivariate analysis has identified age (over 30 years), initial leukocytosis (30·109/l and more) and t(4;11) among the main clinical prognostic factors. Gene mutation detection evaluated in a small number of patients (8/36) is not a poor prognostic sign. There is a need for further investigations with centralized evaluation of the mutation status of leukemic cells and the clearance of minimal residual disease.
Published: 2017
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2. Acute Ph-negative lymphoblastic leukemias in adults: Risk factors in the use of the ALL-2009 protocol

Author: E N Parovichnikova, A N Sokolov, V V Troitskaya, G A Klyasova, M A Rusinov, Z Kh Akhmerzaeva, L A Kuzmina, S N Bondarenko, O Yu Baranova, T S Kaporskaya, E N Zotina, E E Zinina, O S Samoilova, L V Gavrilova, K D Kaplanov, T S Konstantinova, V A Lapin, S K Kravchenko, E O Gribanova, E E Zvonkov, O A Gavrilina, G A Baskhaeva, G M Galstyan, T N Obukhova, I V Galtseva, S M Kulikov, and V G Savchenko
Subjects: acute lymphoblastic leukemia, risk factors, cytogenetic abnormalities, Medicine
Abstract: Aim. To analyze well-known risk factors (RFs), such as age, immunophenotype, baseline leukocytosis, enhanced lactate dehydrogenase (LDH) activity, time to achieve complete remission, a risk group, and cytogenetic abnormalities) in patients with acute lymphoblastic leukemia (ALL) in the use of the ALL-2009 protocol. Subjects and methods. The protocol covered 298 patients (137 women (including 13 pregnant women) and 161 men) aged 15 to 55 years (median age 28 years) with Ph-negative ALL. The phenotype was unknown in 6 patients. Three (1%) were ascertained to have a biphenotypic variant. 182 (62.4%) patients were found to have B-cell ALL (early pre-B ALL (n=51); common ALL (n=92), and pre-B ALL (n=39); 107 (36.6%) patients had T-cell ALL (early T-ALL (n=56); thymic T-ALL (n=41), and mature T-ALL (n=10). According to the baseline clinical and laboratory parameters (leukocytosis of 30·109/l and more for B-ALL; and that of 100·109/l and more for T-ALL; phenotype В-I for B-ALL, phenotype Т-I-II-IV for T-ALL; LDH activity was more than twice the normal values; the presence of translocation t(4;11)), the high-risk group included most patients with B-ALL (n=110 (72.8%)) and T-ALL (n=76 (76%)). Thirty-five patients with T-ALL underwent autologous bone marrow transplantation (BMT). Allogeneic BMT was performed in 18 (7%) of the 258 patients who had undergone an induction phase. Results. Five-year overall survival for all the patients included in the investigation was 59%; relapse-free survival was 65%, which was significantly different in the patients with B-ALL and in those with T-ALL: the overall survival rates were 53.3 and 67.5% (p=0.1); the relapse-free survival was 56 and 79% (p=0.005), respectively. Multivariate analysis including the well-known RFs demonstrated that the latter for T-ALL were of no independent prognostic value and only the patient’s age was identified for B-ALL (p=0.013). Conclusion. A lower chemotherapeutic load and a small number of allogeneic BMTs did not affect total positive treatment results in adult patients with ALL, by complying with the principle achieving the continuity of cytostatic effects and by preserving the total cytostatic loading dose. The results of the Russian investigation casts some doubt on the necessity of using very intensive consolidation cycles and performing a large number of allogeneic BMTs in adult patients with ALL.
Published: 2016

3. Autologous hematopoietic stem cell transplantation as late high-dose consolidation in adult patients with T-cell lymphoblastic leukemias: Results of a Russian multicenter study

Author: E N Parovichnikova, L A Kuzmina, L P Mendeleeva, G A Klyasova, V V Troitskaya, A N Sokolov, Z Kh Akhmerzaeva, S K Kravchenko, E O Gribanova, E E Zvonkov, S N Bondarenko, O Yu Baranova, T V Ryltsova, L V Gavrilova, E E Zinina, A S Pristupa, T S Kaporskaya, N V Minaeva, O S Samoilova, T S Konstantinova, V A Lapin, K D Kaplanov, I V Kryuchkova, A S Nizamutdinova, A V Klimovich, E A Borisenkova, V I Moskov, T V Gaponova, T V Obukhova, I V Galtseva, M A Rusinov, S M Kulikov, and V G Savchenko
Subjects: t-cell acute lymphoblastic leukemias, autologous hematopoietic stem cell transplantation, Medicine
Abstract: Aim. To analyze the efficiency of the ALL-2009 protocol (ClinicalTrials.gov NCT01193933) in patients with T-cell leukemias, particularly the role of autologous hematopoietic stem cell transplantation (auto-HSCT) after non-myeloablative BEAM conditioning, followed by maintenance therapy. Subjects and methods. Since 2009, the ALL-2009 study has enrolled 90 patients with T-cell acute lymphoblastic leukemia (T-ALL), the treatment results were assessed in 86 patients: 6 and 28 patients underwent allogeneic HSCT and auto-HSCT, respectively. A landmark analysis was used to compare survival rates in patients who had undergone auto-HSCT and in those who had not. For this, the median time from complete remission to the date of auto-HSCT was determined (the median was 6 months). Then to compare with the auto-HSCT group, only 27 patients who had been in complete remission for 6 months or more were included in a chemotherapy group. Results. The achievement of complete remission in patients with thymic T-ALL (100%) was significantly higher than in those with early (85.7%) or mature (70%) variants. The patients with early and mature T-ALL as compared to those with thymic T-ALL showed high death rates in the remission induction (7.4 and 10% versus 0) and the patients with mature T-ALL had a higher proportion of refractory forms (20% versus 0). The 5-year overall and relapse-free survival rates in all the T-ALL patients were 66 and 76%, respectively. After auto-HSCT, the risk of recurrence was 0% versus 21% after chemotherapy (p=0.03). The relapse-free survival rates significantly differed in the auto-HSCT and non-auto-HSCT groups: 100 and 66%, respectively (p=0.047). Conclusion. The long-term survival rates obtained during this multicenter study in the T-ALL patients treated according to the ALL-2009 protocol, the basis for which is the principle of continuity of cytostatic effects, are exclusively optimistic. Late consolidation with auto-HSCT following non-myeloablative BEAM conditioning, followed by maintenance therapy, considerably reduces the risk of recurrence.
Published: 2015

4. Russian experts' clinical guidelines for acute myeloid leukemia treatment in patients less than 60 years of age

Author: V G Savchenko, E N Parovichnikova, B V Afanas'ev, S V Gritsaev, S V Semochkin, S N Bondarenko, V V Troitskaia, A N Sokolov, L A Kuz'mina, G A Kliasova, O Iu Baranova, V A Lapin, T S Konstantinova, O S Samoĭlova, T S Kaporskaia, and S V Shatokhin
Subjects: acute myeloid leukemias, allogeneic bone marrow transplantation, russian guidelines, Medicine
Abstract: The purpose of the paper is to present Russian experts' consolidated opinion about acute myeloid leukemia (AML) treatment in adult patients aged less than 60 years. The guidelines have been elaborated having regard to foreign publications and Russian experience, on the basis of global and Russian clinical trials to treat AML and to define indications for allogeneic bone marrow transplantation in patients during first complete remission.
Published: 2014

5. Efficiency of treatment of adult patients with acute T-lymphoblastic leukemia according to the ALL-2009 protocol of the Russian Acute Leukemia Study Group

Author: E N Parovichnikova, G A Kliasova, V V Troitskaia, A N Sokolov, L A Kuz'mina, L P Mendeleeva, S K Kravchenko, V V Ryzhko, S N Bondarenko, E A Kariakina, O Iu Baranova, V A Lapin, T V Ryl'tsova, L V Gavrilova, A S Pristupa, T S Kaporskaia, T P Zagoskina, O S Samoĭlova, A V Klimovich, T S Konstantinova, N A Vopilina, O P Skamorina, K D Kaplanov, E E Zinina, E V Domracheva, I V Gal'tseva, S M Kulikov, and V G Savchenko
Subjects: acute t-lymphoblastic leukemias, adult patients, treatment, all-2009 protocol of the russian acute leukemia study group, Medicine
Abstract: AIM: To present the results of treatment in adult patients with acute T-lymphoblastic leukemia (T-ALL) according to the ALL-2009 protocol of the Russian Acute Leukemia Study Group, the basic principle of which is continuation of cytostatic treatment, early switch from prednisolone to dexamethasone, and long-term use of L-asparaginase/MATERIAL AND METHODS: The results of diagnosis and treatment were analyzed in 70 patients with different immunological variants of T-ALL treated in the Russian multicenter trial/RESULTS: Out of the 70 patients with T-ALL, its early immunotype was determined in 32 (45.7%) cases, the thymic and mature immunotypes were found in 31 (44.3%) and 7 (10%) cases, respectively. The median age of the patients with T-ALL was 28 (ranged from 15 to 54) years; men were twice more than women (48 and 22, respectively). Bone marrow lesion was noted in all the patients with early T-ALL and in 80% of the patients with thymic and mature T-ALL. The enlarged mediastinum was significantly more frequently detected in mature T-ALL (100%) than in its early (53.4%) and thymic (60.7%) variants. Therapeutic effectiveness was evaluated in 58 patients. An analysis was made in January 2013. Induction therapy resulted in complete remission in 49 (84.5%) patients. The refractory course of the disease was recorded in 5 (8.6%) cases; early death was in 4 (6.9%). The rate of complete remission in thymic T-ALL, unlike in the early (72%) and mature (71.4%) variants, was significantly higher (100%) due to the absence of resistant forms and early mortality. Moreover, it should be noted that only the patients with early T-ALL (16%) died during the induction phase. In the patients with different variants of T-ALL, the overall and relapse-free survival rates were not significantly different, accounting for 67.2 and 76.2%, respectively. Multivariate analysis revealed no prognostically unfavorable factors that determined long-term results/CONCLUSION: The ALL-2009 protocol is reproducible in any regions of the Russian Federation and highly efficient in treating patients with T-ALL.
Published: 2013

6. The influence of the substrate temperature change character during the growth on the topology of the Ge/Si(100) film surface

Author: L S Lunin, M D Bavizhev, I A Sysoev, V A Lapin, D S Kuleshov, and F F Malyavin
Subjects: молекулярно-лучевая эпитаксия, германий, низкотемпературный слой, атомно-силовая микроскопия, Engineering (General). Civil engineering (General), TA1-2040
Abstract: The possibility of roughness reducing of the Ge/Si (100) film using low-temperature layer of Ge (LT-Ge) has been investigated. It was shown that the substrate temperature change character during the growth process influences on the surface morphology of the grown Ge/LT-Ge/Si films. Samples were obtained by the method of molecular-beam epitaxy.
Published: 2012

7. The first results of treatment for adult acute myeloid leukemia according to the AML-01.10 protocol of the Research Group of the Hematology Centers of Russia

Author: E N Parovichnikova, G A Kliasova, A N Sokolov, V V Troitskaia, A V Kokhno, L A Kuz'mina, I I Shaforostova, V V Ryzhko, S K Kravchenko, S N Bondarenko, V A Lapin, A S Pristupa, T S Konstantinova, T P Zagoskina, I V Ialykomov, V I Moskov, L V Anchukova, T S Kaporskaia, E M Volodicheva, K D Kaplanov, E V Kondakova, O S Samoĭlova, L V Gavrilova, S M Kulikov, and V G Savchenko
Subjects: results of the aml-01.10 protocol, high-dose anthracycline antibiotic, Medicine
Abstract: Aim. To give the preliminary results of the AML-01.10 Russian multicenter randomized trial to treat adult acute myeloid leukemia (AML), the basic principle of which is to use high-dose anthracycline antibiotics in induction/consolidation. Subjects and methods. By December 2011, 145 patients with AML had been randomized from 18 hematology centers of 15 cities and towns of the Russian Federation; the median age of all the patients was 44 years. Seventy-one patients were analyzed in August 2011 (a 1.5-year follow-up). Results. The efficiency of 2 courses 7+3 using high-dose daunorubicin (60 mg/m2 per administration) and continuous infusion of cytarabine during the second course was high and comparable with that in the use of a high-dose HAM protocol as a second induction course and can achieve a complete remission in 74.6%. The protocol toxicity evaluated from its early mortality (11.3%) and its death in complete remission (16.6%) was permissible, particularly by taking into consideration the multicenter pattern of the trial. At the completion of analysis, 53 (68.8%) out of the 77 patients on whom the data on their vital status were available were alive. In this follow-up period, the frequency of recurrences was 19.2% (10/52). Only 3 (4.2%) patients out of the 71 patients in whom the efficiency of the protocol had been completely evaluated underwent allogeneic bone marrow transplantation. Conclusion. The total high dose (720 mg/m2) of anthracycline antibiotics, which is used in the period of induction and consolidation, determines the long periods of myelosuppression and intercourse intervals. Protocol deviations (no course of consolidation therapy, lower-dose idarubicin during consolidation therapy, a course of low-dose cytarabine between the courses of induction and consolidation chemotherapy, and very long intercourse intervals) were recorded in a total of 20 (28%) patients.
Published: 2012

8. Pilot results of therapy of adult Ph-negative acute lymphoblastic leukemia according to the protocol of Research Group of Russian Hematological Centers ALL-2009

Author: Elena Nikolaevna Parovichnikova, G A Klyasova, V G Isaev, A N Sokolov, A V Kokhno, V V Troitskaya, E V Mavrina, E E Khodunova, E N Ustinova, E O Gribanova, S K Kravchenko, V V Ryzhko, T S Kaporskaya, O Yu Baranova, S N Bondarenko, A S Nizametdinova, E V Kondakova, T V Ryl'tsova, A N Alufer'eva, O S Samoylova, O P Skamorina, L V Gavrilova, A S Pristupa, N A Vopilina, T S Konstantinova, I V Kryuchkova, L V Anchukova, T S Tikunova, K D Kaplanov, V A Lapin, V A Tumakov, M N Kozmina, S A Chernysh, E I Podol'tseva, S M Kulikov, Yu R Davidyan, V G Savchenko, E N Parovichnikova, T V Ryltsova, A N Aluferieva, O S Samoilova, and E I Podoltseva
Subjects: adult ph-negative acute lymphoblastic leukemia, sensitivity to prednisolone, l-asparaginasa, Medicine
Abstract: Aim. To review results of 2-year experience in execution of the protocol on the treatment of adult acute Ph-negative lymphoblastic leukemia ALL-2009. Material and methods. Of 111 patients registered in the study from November 2008 to December 2010 the analysis covered 96 patients from 23 hematological centers in 18 towns of the RF. Results. Treatment according to the Protocol ALL-2009 resulted in achievement of a complete remission in 91.2% patients with low early lethality of 5.5%. Postremission lethality fell to 3.7% versus previous studies (22%). Overall 2-year survival and recurrence-free survival reached 77.6 and 78.4%, respectively. Detection of any chromosomic aberrations significantly affected recurrence-free survival: 74 vs 100% in patients with normal karyotype. Conclusion. Protocol All-2009 demonstrates high efficacy in moderate toxicity and good reproducibility in any hematologic center.
Published: 2011

9. Toxicity of different treatment protocols for acute myeloid leukemias in adults: the results of four Russian multicenter studies

Author: E N Parovichnikova, S A Savchenko, G A Klyasova, V G Isayev, A N Sokolov, S M Kulikov, E N Ustinova, E O Gribanova, V V Ryzhko, N D Khorosko, S K Kravchenko, G M Galstyan, T S Konstantinova, T P Zagoskina, I S Zyuzgin, K D Kaplanov, V I Moskov, I V Sokolova, L V Anchukova, V A Lapin, A B Loginov, V A Tumakov, A V Korobkin, G I Milyutina, O S Samoilova, T S Tikunova, A S Pristupa, E V Kondakova, N P Domnikova, L V Gavrilova, N A Obidina, O V Porokhina, G B Rekhtman, V N Mashchuk, N K Khuazheva, T S Kaporskaya, M E Golubeva, A G Maksimov, M A Ploskikh, S N Menshakova, V I Maltsev, V A Rossiyev, and G I Pilipenko
Subjects: acute myeloid leukemias, toxicity, infectious complications, early mortality, Medicine
Abstract: Aim. To comparatively analyze the toxicity of 4 treatment protocols in patients with acute myeloid leukemia (AML), which were used in the Russian multicenter center in 1992 to 2009. Materials and methods. The information obtained in 4 Russian multicenter studies conducted in 33 hematology departments of 26 cities and towns of the Russian Federation in 1992 to 2009 was analyzed. Randomization was made in 243 patients with AML (median age 38 years) in 1992-1995, 396 patients (median age 39 years) in 1995-1999, 392 patients (median age 39 years) in 2001-2006, and 137 patients (median age 40 years) in 2006-2009. The analysis excluded patients with acute promyelocytic leukemias who were recruited in the AML-92 and AML-95 studies. These patients' statutory forms adequately filled in were 60-70% therefore toxicity was analyzed on the basis of the data of 631 patients. Results. The baseline clinical and laboratory parameters in the patients enrolled in the studies in different years slightly differ in the count of leukocytes at the onset of the disease and in the level of lactate dehydrogenase (LDH): the recent studies revealed a larger number of high-risk group patients (leukocytes more than 30109/l; LDH more than 500 units) possibly due to the later diagnosis of AML. During the studies, the number of complete remissions remained as before (55%) after the first course and increased from 65 to 78% after the second course using cytosine arabinoside in high doses. Despite treatment intensification, mortality in the induction period remained as before (19-21%). Remission mortality decreased from 18 to 10-13%. The long-term results of using the aggressive therapy did not differ from those obtained during the standard treatment protocols. The duration of leucopenia after standard induction courses during the all studies remained equal (17-19 days); the exclusion was a HAM course as the second induction course after which the duration of neutropenia was much more than that of the standard course (17 and 10 days, respectively). During the study years, there was an increase in platelet transfusion volumes (from 20 to 53 doses during the first course and from 7 to 28 doses during the second course) and a reduction in the percentage of severe hemorrhagic complications. The incidence of pneumonias remained at the same level (40-50%) during the induction courses and that of septic complications and necrotic enteropathy considerably decreased from 40-46 to 17-19%. The incidence of invasive aspergillosis during the current programs from AML treatment was 10% (two induction courses), that of invasive candidiasis was 4.7% (two induction courses). Conclusion. The long-term results of treatment for AML were virtually unchanged regardless significant therapy intensification. Mortality remained high during induction treatment and in the postremission period. Its cause is severe infectious complications developing during myelotoxic agranulocytosis. The results of the analysis provide the basis for developing a new AML treatment protocol that should take into account all the merits and demerits of the previous protocols and provide a toxicity-treatment efficiency balance.
Published: 2010

10. Preliminary results of a multicenter randomized study on the treatment of acute promyelocytic leukemias

Author: E N Parovichnikova, V G Savchenko, I A Demidova, V G Isaev, E N Shuravina, E N Ustinova, E O Gribanova, M Zh Alexanyan, A V Misyurin, E V Domracheva, Yu V Olshanskaya, N D Khoroshko, S K Kravchenko, T S Konstantinova, L V Anchukova, K Kaplanov, T P Zagoskina, S A Volkova, L В Filatov, G В Rekhtman, I Sokolova, V N Mashuk, G I Milyulina, V A Lapin, T N Perekatova, E I Sviridova, A S Pristupa, and I S Zyuzgin
Subjects: fish, acutepromyelocytic leukemia, polymerase chain reaction, randomisation, Medicine
Abstract: Aim. To study efficacy of maintenance therapy of patients with acute promyelocyte leukemia (APL) in the APL treatment Russian multicenter trial. Material and methods. The trial was made with participation of 18 hematological departments of clinics in Russia. A total of 68 APL patients entered the trial. The maintenance therapy consisted of 5day courses of cytostatic drugs which alternated or did not altenate with 5-day courses of ATRA. Cytogenetic tests were made in 31 patients, t(15;17) was detected in 26 of them. Molecular examination conducted in 28 patients discovered chimeric transcript PML/RARa in 26 of them. Of 20 patients examined in Hematological Research Center, 7 (35%) had a bcr 1/2 variant of the transcript PML/RARa, 13 (657c) - bcr 3 variant. Results. 65 patients were eligible for assessment. A complete remission was achieved in 90% cases. No resistance was observed. In follow-up within 30 months the recurrence rate was similar on both treatments. The results of the induction therapy and survival in patients with different variants of the transcripts were also simitar. Overall 2.5 year survival for all the patients was 77%, recurrence-free 80%. The survival analysis in patients with leukocytosis higher and lower 10 lO9/! found no statistical differences by the survival. Patients with hyperleukocytosis had higher early lethality than patients with leukocytes under 10 Iff/I (25% vs 5.3%, p = 0.03). Conclusion. The APL 06.01 protocol showed high efficacy of the relevant maintenance which provides a complete molecular remission in the majority of patients with probable recurrence-free 2.5 year survival 80%.
Published: 2004

11. From quantitative measurement to understanding public demand: Exploring non-survey methods in applied regional research

Author: K. Ye. Petrov, E. N. Minchenko, and V. S. Lapin
Subjects: social listening, sml, big data, social polling, social trust, public opinion, political consciousness, trust in institutions, Sociology (General), HM401-1281
Abstract: The article builds on the well-developed problem of studying trust in society towards social institutions, as well as between individuals. Currently, contact quantitative sociology faces a number of challenges, and the level of consent to participate in surveys is steadily falling. In order to reliably assess public opinion, non-contact tools for studying the digital environment are already required. The application of non-survey techniques for collecting big data using a pre-formed thesaurus allows us to select data for analysis and circumvent the problems associated with respondent recruitment. The application of SML approach to analyze digital publications of Russian-speaking users from Novosibirsk (more than 450 thousand publications) collected in 2020 has been considered. The combination of quantitative and qualitative methods allowed us to describe the audience and categorize the areas of public distrust and dissatisfaction. The application of this approach can be useful for managerial tasks aimed at increasing trust in society. Thus, the study is a valuable contribution to the development of modern sociology and its applied aspects.
Published: 2023
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12. Autoantibody levels in blood of H. pylori-infected patients with chronic gastritis

Author: E. V. Mokhonova, V. A. Lapin, D. A. Melent'ev, D. V. Novikov, N. V. Neumoina, K. M. Perfilova, M. V. Neumoina, T. A. Troshina, I. V. Shutova, and V. V. Novikov
Subjects: helicobacter pylori, chronic gastritis, autoantibodies, autoimmune diseases, rheumatoid arthritis, systemic lupus erythematosus, autoimmune thyroiditis, Immunologic diseases. Allergy, RC581-607
Abstract: Helicobacter pylori (H. pylori) increases the risk of diseases associated with mucous membrane inflammation of gastrointestinal tract, in particular, gastritis, stomach ulcers, and duodenal ulcers. It may also induce a chronic immune response, causing damage to the mucous membrane and development of these diseases. In addition, the role of H. pylori in the initiation of a wide range of autoimmune diseases is discussed. The aim of this study was to assess the level of autoantibodies – markers of various autoimmune diseases in the blood of H. pylori-infected patients with chronic gastritis. We used samples of whole peripheral blood from 267 primary patients with chronic gastritis in the acute stage. The presence of H. pylori in gastric juice from patients was determined using real-time PCR. The level of autoantibodies to double-stranded and single-stranded DNA, autoantibodies to thyroglobulin, thyroid peroxidase, concentration of rheumatoid factor, IgG autoantibodies to the cyclic citrullinated peptide, IgM and IgG autoantibodies to beta(2)-glycoprotein were determined by the enzyme immunoassay. The average level of rheumatoid factor in blood serum was similar for H. pylori-infected and non-infected patients, and did not exceed the normal values. The level of antibodies to cyclic citrullinated peptide, one of the sensitive markers of rheumatoid arthritis, was increased in all patients, being, however, significantly lower in H. pylori-infected patients compared with non-infected persons. Autoantibodies to thyroglobulin, thyroid peroxidase are considered classic markers of autoimmune diseases of the thyroid gland. In blood of H. pylori-infected patients we have found an increased concentration of autoantibodies to thyroglobulin and thyroid peroxidase in comparison with non-infected ones, but the average level of these antibodies did not exceed the normal range. Any differences in the levels of systemic lupus erythematosus serological markers, i.e., autoantibodies to double-stranded and single-stranded DNA, were found between H. pylori-infected and non-infected patients. The levels of thrombosis risk marker in patients with systemic lupus erythematosus (IgG and IgM autoantibodies to beta(2)-glycoprotein) were also within the normal ranges. However, in H. pylori-infected patients, it even turned out to be statistically significantly lower than in non-infected ones. Thus, no data have been obtained on increased levels of the tested markers of autoimmune pathology in blood of H. pylori-infected patients with chronic gastritis at the acute stage. However, this does not allow us to make an unambiguous conclusion that the influence of H. pylori does not affect the development of immunological changes associated with autoimmune diseases.
Published: 2023
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13. Treatment outcomes for acute T-lymphoblastic leukemias/lymphomas: data from the ALL-2016 multicenter prospective randomized trial

Author: O. A. Aleshina, I. V. Galtseva, E. S. Kotova, G. I. Isinova, T. N. Obukhova, V. N. Dvirnik, A. B. Sudarikov, M. E. Grishunina, O. S. Samoilova, K. D. Kaplanov, V. A. Lapin, S. N. Bondarenko, E. S. Fokina, N. V. Minaeva, T. S. Konstantinova, Yu. V. Sveshnikova, E. E. Zinina, A. S. Antipova, O. Yu. Baranova, E. A. Borisenkova, Yu. O. Davydova, N. M. Kapranov, S. M. Kulikov, Yu. A. Chabaeva, V. V. Troitskaya, and E. N. Parovichnikova
Subjects: acute lymphoblastic leukemia, lymphoblastic lymphoma, minimal residual disease, hematopoietic stem cell transplantation, Diseases of the blood and blood-forming organs, RC633-647.5
Abstract: Background. The effectiveness of therapy for acute T-lymphoblastic leukemia (T-ALL) and T-lymphoblastic lymphoma (T-LBL) has significantly improved over the past decades, including through the implementation of hematopoietic stem cell transplantation (HSCT). The Russian multicenter ALL-2009 study (ClinicalTrials.gov NCT01193933) showed that performing autologous HSCT (auto-HSCT) in patients with T-ALL/LBL improves long-term results. However, the study was non-randomized and the need for auto-HSCT in clinical practice requires careful study.Aim. To assess the significance of auto-HSCT in patients with T-ALL/LBL in the framework of ALL-2016 multicenter, prospective, randomized study (ClinicalTrials.gov NCT03462095).Materials and methods. The study included 109 adult patients with T-ALL/LBL (m:f 82:27). Median age was 31 (18– 52) years. T-ALL was diagnosed in 88 (81 %) patients, T-LBL in 21 (19 %) patients. All patients are treated according to the ALL-2016 protocol. Using the web platform, upon completion of induction therapy (+70 days), all T-ALL/LBL patients who achieved clinical and hematological remission were randomized to the auto-HSCT arm or chemotherapy alone (CT). Centralized monitoring of minimal residual disease (MRD) in bone marrow samples was performed by multicolor flow cytometry at the control points according to the ALL-2016 protocol. Statistical analysis was performed using SAS 9.4.Results. 87 patients with T-ALL/LBL were randomized: 44 to the auto-HSCT arm and 43 to the CT arm. Further analysis included 25 patients who underwent auto-HSCT and 36 patients receiving only CT. Three-year relapse-free survival in T-ALL is estimated at 62 % (auto-HSCT) vs. 81 % (CT) (p = 0.3422), and in T-LBL – 67 % (auto-HSCT) vs. 79 % (CT) (p = 0.59). MRD persistence on the +70th day of therapy according to the ALL-2016 protocol was determined in 40 % of patients (autoHSCT) and in 67 % (CT) (p = 0.057). In a multivariate analysis, it was determined that T-ALL from early T-cell precursor (ETP-variant) and MRD persistence after the end of II phase induction are the main risk factors for relapse in the treatment according to the ALL-2016 protocol.Conclusion. Performing auto-HSCT both in patients with T-ALL and T-LBL, and with MRD persistence on day +70 according to the ALL-2016 protocol did not improve long-term results. The development of new programs for the treatment of patients with MRD persistence, as well as the ETP variant of T-ALL, is of current interest.
Published: 2023
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14. Current status of hematopoietic stem cell transplantation in Russia

Author: L. P. Mendeleeva, V. G. Savchenko, L. S. Lubimova, I. A. Demidova, B. V. Afanassiev, L. S. Zubarovskaya, T. P. Zagoskina, I. S. Zuzgin, T. S. Konstantinova, V. A. Lapin, I. A. Lisukov, A. B. Loginov, N. A. Obidina, V. A. Rossiev, and S. V. Shamansky
Subjects: hematopoietic stem cell transplantation, autologous and allogeneic transplantation, russian interregional register, Diseases of the blood and blood-forming organs, RC633-647.5
Abstract: Russian Interregional Register of hematopoietic stem cell transplantation was established in 2000. 11 transplant centres from 7 Russian cities are including in Register now. In this analysis we applied transplant activity survey data from 01.01.1996 to 31.12.2006. A total 1118 transplants (846 – autologous and 272 – allogeneic) were carried during this period.
Published: 2022
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15. The concentration of cadmium and lead in the solid and finely dispersed phases of snow and hair of the population of Gorny Altai

Author: E. A. Chanchaeva and V. S. Lapin
Subjects: cadmium, lead, snow, hair, gorno-altaisk, Medicine
Abstract: To create a systematic database on the presence of metals in the environment and the human body, it is necessary to conduct local studies in different regions of the Russian Federation. A comprehensive analysis of the content of cadmium and lead in different coenotic links, including the human body, has not been carried out in the Altai Republic. The aim of the study was to reveal the level of lead and cadmium accumulation in the solid and finely dispersed phases of snow and hair of the population of Gorno-Altaisk. Material and methods. The content of lead and cadmium in the snow and hair of the population of Gorno-Altaisk was estimated by the atomic absorption method. Snow samples were taken in the areas of 10 central coal boilers, hair samples were taken from 122 volunteers permanently residing in the city. Results. The concentration of metals in snow water exceeded the maximum allowable concentrations: for cadmium (0.004–0.008 mg/kg) by 3.8–8.2 times; for lead (0.008–0.469 mg/kg) by 2–15.6 times. In the solid phases of snow, the content of metals exceeded the permissible level by about 3 times. The average value of the concentration of cadmium in the hair of the population was 0.16 mg/kg, which did not exceed the all-Russian reference value (0.25 mg/kg), the proportion of excess among the population was 6.5 %. The lead content (3.18 mg/kg) approximately corresponded to the all-Russian values (3.0 mg/kg), the excess was found among 43 % of the population. Conclusion. As a result of the widespread use of solid fuels, the presence of cadmium and lead in the environment increases, which is confirmed by the accumulation of these metals in the snow cover and the accumulation of the analyzed microelements in the hair of the population of Gorno-Altaisk.
Published: 2022
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16. Analysis of the state of immunity in patients with chronic gastritis infected with Helicobacter pylori

Author: Ekaterina V. Mokhonova, V. A. Lapin, D. A. Melentiev, D. V. Novikov, N. V. Neumoina, K. M. Perfilova, M. V. Neumoina, T. A. Troshina, I. V. Shutova, and V. V. Novikov
Subjects: helicobacter pylori, chronic gastritis, lymphocytes, flow cytofluorimetry, rt-pcr, mrna, Infectious and parasitic diseases, RC109-216
Abstract: Helicobacter pylori is considered an etiological agent of chronic gastritis and a number of other diseases of the gastrointestinal tract. The immune response to H. pylori is characterized by the development of both pro-inflammatory and tolerogenic reactions. Against this background, the possibility of forming autoimmune shifts is also assumed. The purpose of the present study was to conduct a comparative analysis of the state of immunity in patients with chronic gastritis in the exacerbation stage associated with and not associated with H. pylori infection. There were used whole peripheral blood (n = 50) and serum (n = 49) samples from 162 patients with primary chronic gastritis at the exacerbation stage, in which the presence or absence of H. pylori DNA was tested by real-time PCR in gastric juice. In the peripheral blood of patients, the relative content of CD4+FoxP3+ cells (T regulators) and CD4+CD161+ cells (IL-17 producing cells) was evaluated using flow cytofluorometry and monoclonal antibodies method, the level of mRNA FoxP3 and mRNA IL-17A was determined using real time RT-PCR, and the concentration of IL-2 and IL-23 was determined using enzyme immunoassay. It has been shown that in H. pylori-infected patients with chronic gastritis in the exacerbation stage in comparison with patients not infected with H. pylori, the content of CD4+FoxP3+ cells, CD4+CD161+ cells does not change in the blood, also with the level of mRNA FoxP3 and mRNA IL-17A. Since the equilibrium between the populations of Th17 cells and T regulators is modulated by IL-2, which is important for generating the population of T regulators, but inhibits polarization of the immune response towards Th17 cells, we conducted a comparative assessment of the serum IL-2 level in patients with chronic gastritis. All patients showed an increase in IL-2 content in comparison with the norm. In this case, the concentration of IL-2 in the blood of infected H. pylori patients was statistically significantly higher than in H. pylori-uninfected patients. An important regulator of the function of Th17 cells is also IL-23, which induces the differentiation of naive T lymphocytes into Th17 cells involved in inflammatory and autoimmune reactions. In this regard, we determined the level of this cytokine in the blood of patients with chronic gastritis. Multiple increase of IL-23 concentration in comparison with normal level and higher content of IL-23 in H. pylori-infected patients in comparison with uninfected patients were revealed. On the basis of the obtained data, it can be concluded that an increase in the concentration of IL-23 does not exclude the possibility of forming autoimmune shifts with its participation in persons with helicobacter infection, but the issue requires further study.
Published: 2022
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17. Construction of norovirus (Caliciviridae: Norovirus) virus-like particles containing VP1 of the Echovirus 30 (Picornaviridae: Enterovirus: Enterovirus B)

Author: D. V. Novikov, D. A. Melentev, V. V. Mokhonov, A. Yu. Kashnikov, N. A. Novikova, V. A. Lapin, E. V. Mokhonova, and V. V. Novikov
Subjects: virus-like particles, norovirus vp1 protein, echovirus 30 vp1 protein, chimeric proteins, vaccines, Microbiology, QR1-502
Abstract: Introduction. Enterovirus (nonpolio) infection is widespread all over the world, registered as sporadic cases and large-scale outbreaks and can cause severe lesions such as serous meningitis. Epidemiological studies have shown that enterovirus (Picornaviridae; Enterovirus) variant Echovirus 30 (E30) is the most frequently detected variant in patients with enterovirus meningitis in the Russian Federation. However, no vaccines to prevent the disease caused by this pathogen have been developed so far. One of the promising modern trends in terms of creating vaccine preparations is the use of virus-like particles (VLPs), including chimeric ones containing the biological structures of viruses belonging to different species. The aim of this work was to obtain norovirus (Caliciviridae; Norovirus) VLPs displaying enterovirus Echovirus E30 full-length VP1 on the surface. Material and methods. The nucleotide sequences of VP1 protein of norovirus genotype GII.4 and VP1 E30 of genotype h circulating in Russia were used. The SN-VP1E30 protein was constructed, in which the shell (S) and the hinge regions of the norovirus VP1 are fused into one molecule with the full-length VP1 of the E30 virus. The protein was expressed in E. coli, purified using affinity chromatography, and characterized by polyacrylamide gel electrophoresis (PAGE) and immunoblotting. VLPs were visualized by electron microscopy. Results. The S N-VP1E30 protein expressed in E. coli as insoluble form, so the conditions for SN-VP1E30 solublisation were defined. Sucrose has been shown to significantly increase the efficiency of renaturation. Electrophoretic mobility comparison of denatured and non-denatured SN-VP1E30 demonstrated that most monomers form high molecular weight compounds. Electron microscopy showed that renatured SN-VP1E30 spontaneously forms empty virus-like particles about 50 nm in diameter. Conclusion. Chimeric protein SN-VP1E30 self-assemble into VLPs displaying the VP1 protein of E30 variant that is highly prevalent in Russia. Further immunological research is necessary to characterize VLPs potential for development of the vaccine for enteroviral meningitis prevention.
Published: 2021
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18. Effect of vacuum sintering conditions on the properties of Y3Al5O12 : Ce luminescent ceramics

Author: L. V. Tarala, A. A. Kravtsov, O. M. Chapura, V. A. Tarala, D. S. Vakalov, F. F. Malyavin, S. V. Kuznetsov, V. A. Lapin, L. V. Kozhitov, and A. V. Popkova
Subjects: General Medicine
Abstract: The aim of this work was to study the effect of vacuum sintering conditions and cerium concentration on the optical, luminescent and thermal properties of yttrium-aluminum garnet based ceramics doped with Се3+ cations. Series of ceramic powders were synthesized and samples of luminescent ceramics having the composition Y3-хСехAl5O12 were synthesized where x was in the range 0.01 to 0.025 f.u. We show that the phase composition and grain size distribution of the ceramic powders do not depend on cerium concentration. Without sintering additives, an increase in vacuum sintering temperature from 1675 to 1800 °C leads to an increase in the optical transmittance of luminescent ceramic specimens from 5 to 55% at a 540 nm wavelength and an increase in the thermal conductivity of the samples from 8.4 to 9.5 W/(m ∙ K). It was found that an increase in cerium concentration leads to a shift of the luminescent band peak from 535 to 545 nm where as the width of the luminescent band decreases with an increase in vacuum sintering temperature from 1675 to 1725 °C.
Published: 2023
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19. Comparison of the treatment results in adult patients with acute Ph-negative lymphoblastic leukemia on protocols of the Russian multicenter studies ALL-2009 and ALL-2016

Author: E. N. Parovichnikova, O. A. Aleshina, V. V. Troitskaya, Yu. A. Chabaeva, A. N. Sokolov, G. A. Isinova, E. S. Kotova, Z. H. Akhmerzaeva, G. A. Klyasova, I. V. Galtseva, Yu. O. Davydova, L. A. Kuzmina, S. N. Bondarenko, O. Yu. Baranova, A. S. Antipova, O. S. Samoilova, M. E. Grishunina, K. D. Kaplanov, T. S. Kaporskaya, T. S. Konstantinova, Yu. V. Sveshnikova, E. A. Borisenkova, E. S. Fokina, N. V. Minaeva, E. E. Zinina, V. A. Lapin, E. O. Gribanova, E. E. Zvonkov, V. N. Dvirnyk, G. M. Galstyan, T. N. Obukhova, A. B. Sudarikov, and S. M. Kulikov
Subjects: Hematology
Abstract: Introduction. Over the past 5 years, signifi cant progress has been achieved in the treatment of patients with Ph-negative acute lymphoblastic leukemia (ALL). Treatment results were compared between two protocols of the Russian multicenter studies «ALL-2009» and «ALL-2016», in which multicomponent high-dose consolidation was not used. The principle of continuity of treatment was observed with modifi cation of doses of cytostatic drugs depending on the depth of cytopenia.Aim – to compare the 5-year results of two studies and to determine the factors of unfavorable prognosis in the treatment of patients with ALL.Materials and methods. The studies were performed from April 2009 to April 2016 (ALL-2009) and from April 2016 to September 2021 (ALL-2016), and 596 patients were included: 330 in ALL-2009 and 266 in ALL-2016. The analysis was performed in March 2022. The median age of patients in ALL-2009 was 28 years (15–55), in ALL-2016 – 32.5 years (18–55). Cytogenetic studies were performed in 242 patients in ALL-2009 (73.3 %) and 236 patients in ALL-2016 (88.7 %). Patients in the ALL-2016 protocol underwent a centralized assessment of minimal residual disease (MRD) by fl ow cytometry on protocol +70 day (after completion of two induction phases), +133 and +190 days. Transplantation of allogeneic stem hematopoietic cells was performed in 7 % of patients in ALL-2009 and in 9 % in ALL-2016.Results. Overall, relapse-free survival (OS, RFS) and the probability of relapse for a period of 3 years from the moment of inclusion of patients in a particular study were 59 %, 63 % and 23 % for ALL-2009, and for ALL-2016 – 64 %, 59 % and 22 %, respectively. For patients with B-cell precursor ALL, two cytogenetic risk groups were formed, in which long-term survival rates differed signifi cantly: the standard group (hyperploid set of chromosomes and normal karyotype) – OS 63 %, RFS 70 %, and high cytogenetic risk (any abnormal karyotype, except for hyperploidy) – OS 49 %, RFS 52 % (р = 0.001, р = 0.0014). In T-ALL, cytogenetic markers had no prognostic value, but the immunophenotype of early T-cell precursor turned out to be an important predictor of poor prognosis (the probability of relapse was 52 % compared with 15 % for all other immunophenotypic variants). According to the results of centralized monitoring of MRD, it was determined that for B-cell precursor ALL, the signifi cant negative factors are the high cytogenetic risk group and positive MRD status at +70 day, and for T-cells, the early immunophenotype and positive MRD status at +133 day.
Published: 2022
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20. Interim results of the PML-16, PML-19 protocols for primary mediastinal large B-cell lymphoma therapy

Author: N. G. Gabeeva, D. A. Koroleva, S. A. Tatarnikova, A. K. Smolianinova, D. S. Badmazhapova, S. Yu. Smirnova, E. E. Nikulina, A. V. Belyaeva, E. G. Gemdzhian, V. A. Lapin, E. R. Moskalets, I. E. Kostina, Y. K. Mangasarova, S. A. Shutov, B. V. Biderman, A. B. Sudarikov, T. N. Obukhova, A. M. Kovrigina, G. M. Galstyan, and E. E. Zvonkov
Subjects: Hematology
Abstract: Introduction. Primary mediastinal lymphoma (PML) is an aggressive lymphoid tumor treatment success of which is determined by induction therapy. To date, none of the standard chemotherapy regimens (CT) have demonstrated an advantage in efﬁcacy. Intensive therapy programs are associated with high toxicity.Aim — to evaluate the efﬁcacy and toxicity of two pilot prospective treatment protocols PML-16 and PML-19 as well as the possibility of using the analysis of freely circulating tumor DNA (ctDNA) to assess MRD in patients with PML.Materials and methods. From January 2016 to January 2022, 34 previously untreated PML patients were included in the study; average age — 32; stage > I — in 60 %; extramediastinal lesions — in 14.7 %; bulky disease — in 73.5 % of patients. Positron emission tomography combined with computed tomography (PET-CT) was performed; ctDNA was determined to assess the completeness of remission.Results. Eighteen patients received treatment according to the PML-16 protocol (6 courses of chemotherapy; 2 blocks of RmNHL-BFM-90 + 4 courses of R-EPOCH). After the end of therapy, all 18 patients achieved PET-negative remission. The next 16 patients received treatment according to the PML-19 protocol (4 courses of chemotherapy; 2 blocks of R-mNHL-BFM-90 + 2 courses of R-EPOCH) in combination with lenalidomide. After the end of therapy, 9 (56 %) patients achieved PET-negative remission; 7 (44 %) retained pathological activity (D4–5 points). After 3 and 6 months 15 (94 %) patients achieved normalization of metabolic activity. Considering the high frequency of false-positive results in patients with PML, a ctDNA study was performed to determine the depth of remission in 15 patients. After the end of therapy, all 15 patients had complete elimination of ctDNA. Of these, 5 (33 %) remained PET-positive at the end of treatment. During further observation, after 3–6 months, in 4 patients the level of metabolic activity decreased to physiological without the use of consolidating therapy. After the end of therapy, one patient suffered the new coronavirus infection, COVID-19. A month later, residual formation of SUVmax 14.2 remained in the mediastinum. The patient is currently under observation. With a median follow-up of 36 months (9 to 76 months) all 34 patients are in remission.Conclusion. The effectiveness of PML-16 made it possible to abandon the consolidation therapy and refuted the idea of the need for 6 courses of CT. The combination of programs based on the application of the principle of high-dose shortpulse induction of remission (R-mNHL-BFM-90) in combination with the prolonged administration of medium doses (R-EPOCH) was crucial in achieving a successful result. The inclusion of lenalidomide in the “PML-19” program made it possible to achieve complete remission in 100 % of cases after 4 courses. The possibility of using DNA analysis to assess MRD in patients with PML was shown.
Published: 2022
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21. Competitive authoritarian regime: tactics of opposition actors

Author: V. S. Lapin
Subjects: democratization, electoral regime, competitive authoritarian regime, opposition, civil society, Political science (General), JA1-92
Abstract: Varieties of modern nondemocratic electoral political regimes is determined by institutional, structural, actor-oriented (procedural) differences between «the new autocracies». The trajectories of political transformation and regime changes in these hybrids depend largely on the specifi c political decisions and actions of key political actors in the process of democratization. This article analyzes the actions of the opposition from the angle of mobilization and cooperation as «winning» tactics in the electoral competitive nondemocratic regimes. The empirical part of the article includes: 1) forming a public protests database in the electoral cycle of 2015 (January-September) in the Central Federal District of Russia, which includes the regional authority elections, members of regional and local legislatures; 2) statistical processing of data of opposition’s participation / nonparticipation in public protests, number of protesters, opposition cooperative actions, issues of protests; 3) designing and measuring empirically observable features of protests make it possible to segment the public protest activity into 2 basic parts: civic activity and mobilization activity – and then to analyze the scope of cooperation of various opposition parties in mobilization actions. These results make it possible to answer the following questions: to what extent Russian opposition actors use public protest activity as mobilization resource and to what extent they are prepared for cooperation in a public protest fi eld?
Published: 2017
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22. A Millimeter-Wave Field-Effect Transistor Based on a Pseudomorphic Heterostructure with an Additional Potential Barrier

Author: S. A. Bogdanov, A. K. Bakarov, K. S. Zhuravlev, V. G. Lapin, V. M. Lukashin, A. B. Pashkovskii, I. A. Rogachev, E. V. Tereshkin, and S. V. Shcherbakov
Subjects: Physics and Astronomy (miscellaneous)
Published: 2021
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23. Modulation and amplification of wave packets in amplifiers with a travelling refractive-index wave

Author: V. A. Lapin, Aleksei S. Kadochkin, D. G. Sannikov, Igor O. Zolotovskii, and M. S. Yavtushenko
Subjects: Physics, Optics, business.industry, Modulation, Wave packet, Amplifier, Physics::Optics, Statistical and Nonlinear Physics, Electrical and Electronic Engineering, business, Refractive index, Atomic and Molecular Physics, and Optics, Electronic, Optical and Magnetic Materials
Abstract: We study the conditions of frequency modulation, spectral broadening, and amplification of a Gaussian pulse – a whispering-gallery-mode (WGM) wave packet (WP) – propagating along a spiral trajectory on the surface of an active cylindrical optical waveguide, in which a travelling refractive-index wave (TRIW) is generated. Analytical expressions are obtained for the dependences of the duration, chirp, and spectral width on the distance travelled by the pulse along the waveguide, as well as on the parameters of the waveguide and the radiation launched into it. It is shown that the interaction of a wave packet with the TRIW leads to a strong frequency modulation of the amplified pulse with the conserved linearity of the chirp. It is demonstrated that this circumstance can be used to generate pico- and subpicosecond pulses with peak powers above 100 kW.
Published: 2021
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24. Time compression of frequency-modulated pulses in fibres with in-fibre refractive index gratings

Author: Igor O. Zolotovskii, V. A. Lapin, Vladimir A. Kamynin, and A. S. Abramov
Subjects: Materials science, Optics, business.industry, Time compression, Statistical and Nonlinear Physics, Electrical and Electronic Engineering, business, Refractive index, Atomic and Molecular Physics, and Optics, Electronic, Optical and Magnetic Materials
Abstract: The dynamics of frequency-modulated pulses in fibres with sequentially inscribed refractive-index gratings having a different period is considered. It is shown that the proposed structure of the fibre can be used to generate picosecond and subpicosecond pulses with peak powers on the order of 1 MW.
Published: 2021
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25. Concentrations of heavy metals in animal hair in an urban setting in the Altai Republic

Author: E. A. Chanchaeva, Yu. V. Kuznetsova, Roman Idelevich Aizman, V. S. Lapin, and T. K. Kurilenko
Subjects: Atmospheric air, Health (social science), Ecology, Chemistry, Public Health, Environmental and Occupational Health, Heavy metals, General Medicine, law.invention, law, Environmental chemistry, Area of residence, Spectral analysis, Atomic absorption spectroscopy, Animal hair
Abstract: The aim of the study was to estimate concentrations of heavy metals in animal hair in an urban setting of the Altai Republic. Methods. The method of atomic absorption spectral analysis was used to determine the content of trace elements (Cd, Pb, Cu, Cr, Mn) in the hair of the outdoor dogs (Canis lupus familiaris) of Gorno-Altaisk. Results. The mean values for the concentration of trace elements in the hair samples of the examined dogs were the following: Cd - 0.13 pg/kg; Pb - 1.23 pg/kg; Cr - 4.0 pg/kg; Cu - 7.8 pg/ kg; Mn - 12.36 pg/kg. Concentrations of trace elements in animal hair was not associated with age, sex and area of residence of the animals. In general, the range of concentrations of the studied elements were comparable with the findings from other settings. A possible source of microelements in animal hair in Gorno-Altaisk is micro-fine solids of emissions from solid fuel heating systems and combustion engines exhaust. Conclusion: rancentrations of heavy metals in animal hair in the study setting is comparable with other settings and seems to reflect the peculiarities of the processes of accumulation of exo-toxicants and self-cleaning of the city air basin.
Published: 2020
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26. DYNAMICS OF HEAVY VIBRATING MACHINES TAKING INTO ACCOUNT INSTABILITY IN TIME OF THEIR PARAMETERS

Author: H.M. Ahaltsov, M. I. Lysytsia, O.A. Chernii, Ye.V. Kalhankov, O. V. Tolstenko, V.I. Dyrda, and V. A. Lapin
Subjects: Basis (linear algebra), Underground mining (hard rock), Process (computing), chemistry.chemical_element, Mechanical engineering, Geology, Uranium, Geotechnical Engineering and Engineering Geology, Instability, Vibration, Amplitude, chemistry, Environmental science, Intensity (heat transfer)
Abstract: Underground mining of uranium ores consists of several technological processes, one of the most important of which is the release of broken rock from the working excavation zone and loading it into transportation vehicles. The issue of increasing the intensity of production requires a simultaneous increase in the productivity of all production processes, including the production of mineral raw materials. At the same time, it is necessary to create both a high-performance and a safe process. This problem is successfully solved by the use of vibration machines with elastic links made of elastomeric materials, which, along with an increase in productivity, can reduce energy consumption and the number of freezes. An integrated approach was used, which includes analytical studies and results of industrial tests of vibratory feeders for underground mining and delivery of uranium ores and building materials. On the basis of the developed algorithm and synergistic model of fatigue microfracture of rubber links in vibratory feeder, mathematical equations were obtained, which made it possible to describe dynamics of feeders with time-depending parameters; when solving the integro-differential equation of the oscillatory system, the dependence of the amplitude characteristics of the feeder on the time of its operation is obtained. An original algorithm and synergistic model were developed, and on their basis, a mathematical apparatus was created, which allowed determining change of amplitude of vibratory feeder oscillations during its operation. On the basis of analytical calculations, a method was developed and introduced for predicting changes of parameters change of oscillation amplitudes of vibratory feeder used for underground mining and feeding of uranium ores.
Published: 2020
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27. New Type of Heterostructures for Powerful pHEMT Transistors

Author: V. G. Lapin, D. V. Gulyaev, A. K. Bakarov, A. B. Pashkovskii, K. S. Zhuravlev, V. M. Lukashin, D. Yu. Protasov, and A. I. Toropov
Subjects: 010302 applied physics, Materials science, Drift velocity, business.industry, Transistor, Heterojunction, Electron, High-electron-mobility transistor, Condensed Matter::Mesoscopic Systems and Quantum Hall Effect, Condensed Matter Physics, 01 natural sciences, law.invention, 010309 optics, Condensed Matter::Materials Science, Depletion region, law, Electric field, 0103 physical sciences, Optoelectronics, Electrical and Electronic Engineering, business, Instrumentation, Saturation (magnetic)
Abstract: A new type of AlGaAs/InGaAs/GaAs heterostructures with energy barriers formed in the AlGaAs transistor layers adjacent to the InGaAs channel, modulation-doped with donors and acceptors is presented. The height of the barriers associated with the potential of the space charge region in AlGaAs layers reaches 0.8 eV, which makes it possible to double the concentration of electrons in the channel, prevent the transition of hot electrons heated by the electric field into surrounding layers, and increase their saturation drift velocity by around $$1.2{-}1.3$$ times. As a result, microwave power output density of the transistor exceeded the world level by more than 50 $$\%$$ .
Published: 2020
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28. Model of Fracture Propagation in Hydraulic Isolation of the Wellbore

Author: V. N. Lapin
Subjects: musculoskeletal diseases, Wellbore, surgical procedures, operative, Isolation (health care), Petroleum engineering, technology, industry, and agriculture, equipment and supplies, Fracture propagation, Geology
Abstract: A model of fracture initiation and propagation along the boundary of a cement plug and a steel casing in a plugged wellbore is proposed. The model allows predicting the conditions of hydraulic isolation failure of a cement plug induced by reservoir pressure. The model describes the stress state of the cement and it’s breakaway from the steel casing caused by the pressure of the pore fluid flowing into the fracture. Numerical experiments show that the fracture propagation velocity and the stability of the hydraulic isolation are sensitive to the reservoir pressure and to the prestressed state of the cement. It is shown also that the quality of cement adhesion to steel and the size of the initial cementing defects have little effect on the initiation conditions and fracture propagation velocity.
Published: 2020
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29. Anthropomorphic Model of States of Subjects of Critical Information Infrastructure Under Destructive Influences

Author: E. A. Maksimova, M. A. Lapina, V. G. Lapin, and A. M. Rusakov
Published: 2022
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30. Search for lepton flavour violation in the eμ continuum with the ATLAS detector in $\sqrt{s} = 7~\mbox{TeV}$ pp collisions at the LHC

Author: The ATLAS Collaboration, G. Aad, B. Abbott, J. Abdallah, A. A. Abdelalim, A. Abdesselam, O. Abdinov, B. Abi, M. Abolins, H. Abramowicz, H. Abreu, E. Acerbi, B. S. Acharya, D. L. Adams, T. N. Addy, J. Adelman, S. Adomeit, P. Adragna, T. Adye, S. Aefsky, J. A. Aguilar-Saavedra, M. Aharrouche, S. P. Ahlen, F. Ahles, A. Ahmad, M. Ahsan, G. Aielli, T. Akdogan, T. P. A. Åkesson, G. Akimoto, A. V. Akimov, A. Akiyama, A. Aktas, M. S. Alam, M. A. Alam, S. Albrand, M. Aleksa, I. N. Aleksandrov, M. Aleppo, F. Alessandria, C. Alexa, G. Alexander, G. Alexandre, T. Alexopoulos, M. Alhroob, M. Aliev, G. Alimonti, J. Alison, M. Aliyev, P. P. Allport, S. E. Allwood-Spiers, J. Almond, A. Aloisio, R. Alon, A. Alonso, M. G. Alviggi, K. Amako, C. Amelung, V. V. Ammosov, A. Amorim, G. Amorós, N. Amram, C. Anastopoulos, T. Andeen, C. F. Anders, K. J. Anderson, A. Andreazza, V. Andrei, X. S. Anduaga, A. Angerami, F. Anghinolfi, N. Anjos, A. Annovi, A. Antonaki, M. Antonelli, S. Antonelli, A. Antonov, J. Antos, F. Anulli, S. Aoun, L. Aperio Bella, R. Apolle, G. Arabidze, I. Aracena, Y. Arai, A. T. H. Arce, J. P. Archambault, S. Arfaoui, J-F. Arguin, E. Arik, M. Arik, A. J. Armbruster, O. Arnaez, C. Arnault, A. Artamonov, G. Artoni, D. Arutinov, M. Asai, S. Asai, R. Asfandiyarov, S. Ask, B. Åsman, D. Asner, L. Asquith, K. Assamagan, A. Astbury, A. Astvatsatourov, G. Atoian, B. Aubert, E. Auge, K. Augsten, M. Aurousseau, N. Austin, G. Avolio, R. Avramidou, D. Axen, G. Azuelos, Y. Azuma, M. A. Baak, G. Baccaglioni, C. Bacci, A. M. Bach, H. Bachacou, K. Bachas, G. Bachy, M. Backes, M. Backhaus, E. Badescu, P. Bagnaia, S. Bahinipati, Y. Bai, D. C. Bailey, T. Bain, J. T. Baines, O. K. Baker, M. D. Baker, S. Baker, F. Baltasar Dos Santos Pedrosa, E. Banas, P. Banerjee, Sw. Banerjee, D. Banfi, A. Bangert, V. Bansal, H. S. Bansil, L. Barak, S. P. Baranov, A. Barbaro Galtieri, T. Barber, E. L. Barberio, D. Barberis, M. Barbero, D. Y. Bardin, T. Barillari, M. Barisonzi, T. Barklow, N. Barlow, B. M. Barnett, R. M. Barnett, A. Baroncelli, A. J. Barr, F. Barreiro, J. Barreiro Guimarães da Costa, P. Barrillon, R. Bartoldus, A. E. Barton, D. Bartsch, V. Bartsch, R. L. Bates, L. Batkova, J. R. Batley, A. Battaglia, M. Battistin, G. Battistoni, F. Bauer, H. S. Bawa, B. Beare, T. Beau, P. H. Beauchemin, R. Beccherle, P. Bechtle, G. A. Beck, H. P. Beck, M. Beckingham, K. H. Becks, A. J. Beddall, A. Beddall, S. Bedikian, V. A. Bednyakov, C. P. Bee, M. Begel, S. Behar Harpaz, P. K. Behera, M. Beimforde, C. Belanger-Champagne, P. J. Bell, W. H. Bell, G. Bella, L. Bellagamba, F. Bellina, G. Bellomo, M. Bellomo, A. Belloni, O. Beloborodova, K. Belotskiy, O. Beltramello, S. Ben Ami, O. Benary, D. Benchekroun, C. Benchouk, M. Bendel, B. H. Benedict, N. Benekos, Y. Benhammou, D. P. Benjamin, M. Benoit, J. R. Bensinger, K. Benslama, S. Bentvelsen, M. Beretta, D. Berge, E. Bergeaas Kuutmann, N. Berger, F. Berghaus, E. Berglund, J. Beringer, K. Bernardet, P. Bernat, R. 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Spighi, G. Spigo, F. Spila, E. Spiriti, R. Spiwoks, M. Spousta, T. Spreitzer, B. Spurlock, R. D. St. Denis, T. Stahl, J. Stahlman, R. Stamen, E. Stanecka, R. W. Stanek, C. Stanescu, S. Stapnes, E. A. Starchenko, J. Stark, P. Staroba, P. Starovoitov, A. Staude, P. Stavina, G. Stavropoulos, G. Steele, P. Steinbach, P. Steinberg, I. Stekl, B. Stelzer, H. J. Stelzer, O. Stelzer-Chilton, H. Stenzel, K. Stevenson, G. A. Stewart, J. A. Stillings, T. Stockmanns, M. C. Stockton, K. Stoerig, G. Stoicea, S. Stonjek, P. Strachota, A. R. Stradling, A. Straessner, J. Strandberg, S. Strandberg, A. Strandlie, M. Strang, E. Strauss, M. Strauss, P. Strizenec, R. Ströhmer, D. M. Strom, J. A. Strong, R. Stroynowski, J. Strube, B. Stugu, I. Stumer, J. Stupak, P. Sturm, D. A. Soh, D. Su, HS. Subramania, Y. Sugaya, T. Sugimoto, C. Suhr, K. Suita, M. Suk, V. V. Sulin, S. Sultansoy, T. Sumida, X. Sun, J. E. Sundermann, K. Suruliz, G. Susinno, M. R. Sutton, Y. Suzuki, S. Swedish, I. Sykora, T. Sykora, J. Sánchez, D. Ta, K. Tackmann, A. Taffard, R. Tafirout, A. Taga, N. Taiblum, Y. Takahashi, H. Takai, R. Takashima, H. Takeda, T. Takeshita, M. Talby, A. Talyshev, M. C. Tamsett, J. Tanaka, R. Tanaka, S. Tanaka, K. Tani, N. Tannoury, S. Tapprogge, D. Tardif, S. Tarem, F. Tarrade, G. F. Tartarelli, P. Tas, M. Tasevsky, E. Tassi, M. Tatarkhanov, Y. Tayalati, C. Taylor, F. E. Taylor, G. N. Taylor, W. Taylor, M. Teixeira Dias Castanheira, P. Teixeira-Dias, K. K. Temming, H. Ten Kate, P. K. Teng, S. Terada, K. Terashi, J. Terron, M. Terwort, M. Testa, R. J. Teuscher, C. M. Tevlin, J. Therhaag, T. Theveneaux-Pelzer, M. Thioye, S. Thoma, J. P. Thomas, E. N. Thompson, P. D. Thompson, R. J. Thompson, A. S. Thompson, E. Thomson, M. Thomson, R. P. Thun, T. Tic, V. O. Tikhomirov, Y. A. Tikhonov, C. J. W. P. Timmermans, P. Tipton, F. J. Tique Aires Viegas, S. Tisserant, T. Todorov, S. Todorova-Nova, B. Toggerson, J. Tojo, S. Tokár, K. Tokunaga, K. Tokushuku, K. Tollefson, M. Tomoto, L. Tompkins, K. Toms, A. Tonazzo, A. Tonoyan, C. Topfel, N. D. Topilin, I. Torchiani, E. Torrence, E. Torró Pastor, J. Toth, F. Touchard, D. R. Tovey, D. Traynor, T. Trefzger, J. Treis, L. Tremblet, A. Tricoli, I. M. Trigger, S. Trincaz-Duvoid, T. N. Trinh, M. F. Tripiana, W. Trischuk, A. Trivedi, B. Trocmé, C. Troncon, M. Trottier-McDonald, A. Trzupek, C. Tsarouchas, J. C-L. Tseng, M. Tsiakiris, P. V. Tsiareshka, D. Tsionou, G. Tsipolitis, V. Tsiskaridze, E. G. Tskhadadze, I. I. Tsukerman, V. Tsulaia, J.-W. Tsung, S. Tsuno, D. Tsybychev, A. Tua, J. M. Tuggle, M. Turala, D. Turecek, I. Turk Cakir, E. Turlay, R. Turra, P. M. Tuts, M. S. Twomey, A. Tykhonov, M. Tylmad, M. Tyndel, D. Typaldos, H. Tyrvainen, G. Tzanakos, K. Uchida, I. Ueda, R. Ueno, M. Ugland, M. Uhlenbrock, M. Uhrmacher, F. Ukegawa, G. Unal, A. Undrus, G. Unel, Y. Unno, D. Urbaniec, E. Urkovsky, P. Urrejola, G. Usai, M. Uslenghi, L. Vacavant, V. Vacek, B. Vachon, S. Vahsen, C. Valderanis, J. Valenta, P. Valente, S. Valentinetti, S. Valkar, E. Valladolid Gallego, S. Vallecorsa, J. A. Valls Ferrer, H. van der Graaf, E. van der Kraaij, R. Van Der Leeuw, E. van der Poel, D. van der Ster, B. Van Eijk, N. van Eldik, P. van Gemmeren, I. van Vulpen, W. Vandelli, A. Vaniachine, P. Vankov, F. Vannucci, R. Vari, E. W. Varnes, D. Varouchas, A. Vartapetian, K. E. Varvell, V. I. Vassilakopoulos, F. Vazeille, G. Vegni, J. J. Veillet, F. Veloso, R. Veness, S. Veneziano, A. Ventura, D. Ventura, M. Venturi, N. Venturi, V. Vercesi, M. Verducci, W. Verkerke, J. C. Vermeulen, A. Vest, M. C. Vetterli, I. Vichou, T. Vickey, G. H. A. Viehhauser, S. Viel, M. Villa, E. G. Villani, M. Villaplana Perez, E. Vilucchi, M. G. Vincter, E. Vinek, V. B. Vinogradov, M. Virchaux, S. Viret, J. Virzi, A. Vitale, O. Vitells, M. Viti, I. Vivarelli, F. Vives Vaque, S. Vlachos, M. Vlasak, N. Vlasov, A. Vogel, P. Vokac, G. Volpi, M. Volpi, G. Volpini, H. von der Schmitt, J. von Loeben, H. von Radziewski, E. von Toerne, V. Vorobel, V. Vorwerk, M. Vos, R. Voss, T. T. Voss, J. H. Vossebeld, A. S. Vovenko, N. Vranjes, M. Vranjes Milosavljevic, V. Vrba, M. Vreeswijk, T. Vu Anh, R. Vuillermet, I. Vukotic, W. Wagner, P. Wagner, H. Wahlen, J. Wakabayashi, J. Walbersloh, S. Walch, J. Walder, R. Walker, W. Walkowiak, R. Wall, P. Waller, C. Wang, H. Wang, J. Wang, R. Wang, S. M. Wang, A. Warburton, C. P. Ward, M. Warsinsky, R. Wastie, P. M. Watkins, A. T. Watson, M. F. Watson, G. Watts, S. Watts, A. T. Waugh, B. M. Waugh, J. Weber, M. Weber, M. S. Weber, P. Weber, A. R. Weidberg, P. Weigell, J. Weingarten, C. Weiser, H. Wellenstein, P. S. Wells, M. Wen, T. Wenaus, S. Wendler, Z. Weng, T. Wengler, S. Wenig, N. Wermes, M. Werner, P. Werner, M. Werth, U. Werthenbach, M. Wessels, K. Whalen, S. J. Wheeler-Ellis, A. White, M. J. White, S. White, S. R. Whitehead, D. Whiteson, D. Whittington, F. Wicek, D. Wicke, F. J. Wickens, W. Wiedenmann, M. Wielers, P. Wienemann, L. A. M. Wiik-Fuchs, P. A. Wijeratne, A. Wildauer, M. A. Wildt, I. Wilhelm, H. G. Wilkens, J. Z. Will, E. Williams, H. H. Williams, W. Willis, S. Willocq, J. A. Wilson, M. G. Wilson, A. Wilson, I. Wingerter-Seez, S. Winkelmann, F. Winklmeier, M. Wittgen, M. W. Wolter, H. Wolters, G. Wooden, B. K. Wosiek, J. Wotschack, M. J. Woudstra, K. Wraight, C. Wright, D. Wright, B. Wrona, S. L. Wu, X. Wu, Y. Wu, E. Wulf, B. M. Wynne, L. Xaplanteris, S. Xella, S. Xie, C. Xu, D. Xu, B. Yabsley, M. Yamada, A. Yamamoto, K. Yamamoto, S. Yamamoto, T. Yamamura, J. Yamaoka, T. Yamazaki, Y. Yamazaki, Z. Yan, H. Yang, U. K. Yang, Y. Yang, Z. Yang, S. Yanush, W-M. Yao, Y. Yao, Y. Yasu, G. V. Ybeles Smit, J. Ye, S. Ye, M. Yilmaz, R. Yoosoofmiya, K. Yorita, R. Yoshida, C. Young, S. Youssef, D. Yu, J. Yu, L. Yuan, A. Yurkewicz, R. Zaidan, A. M. Zaitsev, Z. Zajacova, Yo. K. Zalite, L. Zanello, P. Zarzhitsky, A. Zaytsev, C. Zeitnitz, M. Zeller, P. F. Zema, A. Zemla, C. Zendler, A. V. Zenin, O. Zenin, T. Ženiš, Z. Zinonos, S. Zenz, D. Zerwas, G. Zevi della Porta, Z. Zhan, D. Zhang, H. Zhang, J. Zhang, Q. Zhang, X. Zhang, Z. Zhang, L. Zhao, T. Zhao, Z. Zhao, A. Zhemchugov, J. Zhong, B. Zhou, N. Zhou, Y. Zhou, C. G. Zhu, H. Zhu, Y. Zhu, X. Zhuang, V. Zhuravlov, D. Zieminska, B. Zilka, R. Zimmermann, S. Zimmermann, M. Ziolkowski, R. Zitoun, L. Živković, V. V. Zmouchko, G. Zobernig, A. Zoccoli, Y. Zolnierowski, A. Zsenei, M. zur Nedden, V. Zutshi, and L. Zwalinski
Subjects: Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract This paper presents a search for the t-channel exchange of an R-parity violating scalar top quark ( $\tilde{t}$ ) in the e ± μ ∓ continuum using 2.1 fb−1 of data collected by the ATLAS detector in $\sqrt{s}=7~\mbox{TeV}$ pp collisions at the Large Hadron Collider. Data are found to be consistent with the expectation from the Standard Model backgrounds. Limits on R-parity-violating couplings at 95 % C.L. are calculated as a function of the scalar top mass ( $m_{\tilde{t}}$ ). The upper limits on the production cross section for pp→eμX, through the t-channel exchange of a scalar top quark, ranges from 170 fb for $m_{\tilde{t}}=95~\mbox{GeV}$ to 30 fb for $m_{\tilde{t}}=1000~\mbox{GeV}$ .
Published: 2012
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31. CHOICE OF STEEL AND PRODUCTION TECHNOLOGY AT PRODUCTION OF THIN-WALLED ELECTRICWELDED PIPES AND PRODUCTS OF THEM

Author: O. R. Prudnikova, E. D. Shcherbakov, and V. P. Lapin
Subjects: Mining engineering. Metallurgy, TN1-997
Abstract: It is shown that using of the modern materials and production technologies enables to receive light-wall electric-welded pipes of different categories of drawing out (by analogy with categories of sheet iron drawing out).
Published: 2011
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32. Luminosity determination in pp collisions at $\sqrt{s} = 7$ TeV using the ATLAS detector at the LHC

Author: The ATLAS Collaboration, G. Aad, B. Abbott, J. Abdallah, A. A. Abdelalim, A. Abdesselam, O. Abdinov, B. Abi, M. Abolins, H. Abramowicz, H. Abreu, E. Acerbi, B. S. Acharya, M. Ackers, D. L. Adams, T. N. Addy, J. Adelman, M. Aderholz, S. Adomeit, P. Adragna, T. Adye, S. Aefsky, J. A. Aguilar-Saavedra, M. Aharrouche, S. P. Ahlen, F. Ahles, A. Ahmad, H. Ahmed, M. Ahsan, G. Aielli, T. Akdogan, T. P. A. Åkesson, G. Akimoto, A. V. Akimov, M. S. Alam, M. A. Alam, S. Albrand, M. Aleksa, I. N. Aleksandrov, M. Aleppo, F. Alessandria, C. Alexa, G. Alexander, G. Alexandre, T. Alexopoulos, M. Alhroob, M. Aliev, G. Alimonti, J. Alison, M. Aliyev, P. P. Allport, S. E. Allwood-Spiers, J. Almond, A. Aloisio, R. Alon, A. Alonso, J. Alonso, M. G. Alviggi, K. Amako, P. Amaral, C. Amelung, V. V. Ammosov, A. Amorim, G. Amorós, N. Amram, C. Anastopoulos, T. Andeen, C. F. Anders, K. J. Anderson, A. Andreazza, V. Andrei, M.-L. Andrieux, X. S. Anduaga, A. Angerami, F. Anghinolfi, N. Anjos, A. Annovi, A. Antonaki, M. Antonelli, S. Antonelli, J. Antos, F. Anulli, S. Aoun, L. Aperio Bella, R. Apolle, G. Arabidze, I. Aracena, Y. Arai, A. T. H. Arce, J. P. Archambault, S. Arfaoui, J.-F. Arguin, E. Arik, M. Arik, A. J. Armbruster, K. E. Arms, S. R. Armstrong, O. Arnaez, C. Arnault, A. Artamonov, G. Artoni, D. Arutinov, S. Asai, R. Asfandiyarov, S. Ask, B. Åsman, L. Asquith, K. Assamagan, A. Astbury, A. Astvatsatourov, G. Atoian, B. Aubert, B. Auerbach, E. Auge, K. Augsten, M. Aurousseau, N. Austin, R. Avramidou, D. Axen, C. Ay, G. Azuelos, Y. Azuma, M. A. Baak, G. Baccaglioni, C. Bacci, A. M. Bach, H. Bachacou, K. Bachas, G. Bachy, M. Backes, E. Badescu, P. Bagnaia, S. Bahinipati, Y. Bai, D. C. Bailey, T. Bain, J. T. Baines, O. K. Baker, S. Baker, F. Baltasar Dos Santos Pedrosa, E. Banas, P. Banerjee, Sw. Banerjee, D. Banfi, A. Bangert, V. Bansal, H. S. Bansil, L. Barak, S. P. Baranov, A. Barashkou, A. Barbaro Galtieri, T. Barber, E. L. Barberio, D. Barberis, M. Barbero, D. Y. Bardin, T. Barillari, M. Barisonzi, T. Barklow, N. Barlow, B. M. Barnett, R. M. Barnett, A. Baroncelli, A. J. Barr, F. Barreiro, J. Barreiro Guimar aes da Costa, P. Barrillon, R. Bartoldus, A. E. Barton, D. Bartsch, R. L. Bates, L. Batkova, J. R. Batley, A. Battaglia, M. Battistin, G. Battistoni, F. Bauer, H. S. Bawa, B. Beare, T. Beau, P. H. Beauchemin, R. Beccherle, P. Bechtle, H. P. Beck, M. Beckingham, K. H. Becks, A. J. Beddall, A. Beddall, V. A. Bednyakov, C. Bee, M. Begel, S. Behar Harpaz, P. K. Behera, M. Beimforde, C. Belanger-Champagne, B. Belhorma, P. J. Bell, W. H. Bell, G. Bella, L. Bellagamba, F. Bellina, G. Bellomo, M. Bellomo, A. Belloni, K. Belotskiy, O. Beltramello, S. Ben Ami, O. Benary, D. Benchekroun, C. Benchouk, M. Bendel, B. H. Benedict, N. Benekos, Y. Benhammou, D. P. Benjamin, M. Benoit, J. R. Bensinger, K. Benslama, S. Bentvelsen, D. Berge, E. Bergeaas Kuutmann, N. Berger, F. Berghaus, E. Berglund, J. Beringer, K. Bernardet, P. Bernat, R. Bernhard, C. Bernius, T. Berry, A. Bertin, F. Bertinelli, F. Bertolucci, M. I. Besana, N. Besson, S. Bethke, W. Bhimji, R. M. Bianchi, M. Bianco, O. Biebel, J. Biesiada, M. Biglietti, H. Bilokon, M. Bindi, A. Bingul, C. Bini, C. Biscarat, R. Bischof, U. Bitenc, K. M. Black, R. E. Blair, J.-B. Blanchard, G. Blanchot, C. Blocker, J. Blocki, A. Blondel, W. Blum, U. Blumenschein, C. Boaretto, G. J. Bobbink, V. B. Bobrovnikov, A. Bocci, R. Bock, C. R. Boddy, M. Boehler, J. Boek, N. Boelaert, S. Böser, J. A. Bogaerts, A. Bogdanchikov, A. Bogouch, C. Bohm, V. Boisvert, T. Bold, V. Boldea, M. Boonekamp, G. Boorman, C. N. Booth, P. Booth, J. R. A. Booth, S. Bordoni, C. Borer, A. Borisov, G. Borissov, I. Borjanovic, S. Borroni, K. Bos, D. Boscherini, M. Bosman, H. Boterenbrood, D. Botterill, J. Bouchami, J. Boudreau, E. V. Bouhova-Thacker, C. Boulahouache, C. Bourdarios, N. Bousson, A. Boveia, J. Boyd, I. R. Boyko, N. I. Bozhko, I. Bozovic-Jelisavcic, S. Braccini, J. Bracinik, A. Braem, E. Brambilla, P. Branchini, G. W. Brandenburg, A. Brandt, G. Brandt, O. Brandt, U. Bratzler, B. Brau, J. E. Brau, H. M. Braun, B. Brelier, J. Bremer, R. Brenner, S. Bressler, D. Breton, N. D. Brett, P. G. Bright-Thomas, D. Britton, F. M. Brochu, I. Brock, R. Brock, T. J. Brodbeck, E. Brodet, F. Broggi, C. Bromberg, G. Brooijmans, W. K. Brooks, G. Brown, E. Brubaker, P. A. Bruckman de Renstrom, D. Bruncko, R. Bruneliere, S. Brunet, A. Bruni, G. Bruni, M. Bruschi, T. Buanes, F. Bucci, J. Buchanan, N. J. Buchanan, P. Buchholz, R. M. Buckingham, A. G. Buckley, S. I. Buda, I. A. Budagov, B. Budick, V. Büscher, L. Bugge, D. Buira-Clark, E. J. Buis, O. Bulekov, M. Bunse, T. Buran, H. Burckhart, S. Burdin, T. Burgess, S. Burke, E. Busato, P. Bussey, C. P. Buszello, F. Butin, B. Butler, J. M. Butler, C. M. Buttar, J. M. Butterworth, W. Buttinger, T. Byatt, S. Cabrera Urbán, M. Caccia, D. Caforio, O. Cakir, P. Calafiura, G. Calderini, P. Calfayan, R. Calkins, L. P. Caloba, R. Caloi, D. Calvet, S. Calvet, A. Camard, P. Camarri, M. Cambiaghi, D. Cameron, J. Cammin, S. Campana, M. Campanelli, V. Canale, F. Canelli, A. Canepa, J. Cantero, L. Capasso, M. D. M. Capeans Garrido, I. Caprini, M. Caprini, M. Caprio, D. Capriotti, M. Capua, R. Caputo, C. Caramarcu, R. Cardarelli, T. Carli, G. Carlino, L. Carminati, B. Caron, S. Caron, C. Carpentieri, G. D. Carrillo Montoya, S. Carron Montero, A. A. Carter, J. R. Carter, J. Carvalho, D. Casadei, M. P. Casado, M. Cascella, C. Caso, A. M. Castaneda Hernandez, E. Castaneda-Miranda, V. Castillo Gimenez, N. F. Castro, G. Cataldi, F. Cataneo, A. Catinaccio, J. R. Catmore, A. Cattai, G. Cattani, S. Caughron, A. Cavallari, P. Cavalleri, D. Cavalli, M. Cavalli-Sforza, V. Cavasinni, A. Cazzato, F. Ceradini, C. Cerna, A. S. Cerqueira, A. Cerri, L. Cerrito, F. Cerutti, M. Cervetto, S. A. Cetin, F. Cevenini, A. Chafaq, D. Chakraborty, K. Chan, B. Chapleau, J. D. Chapman, J. W. Chapman, E. Chareyre, D. G. Charlton, V. Chavda, S. Cheatham, S. Chekanov, S. V. Chekulaev, G. A. 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Turecek, I. Turk Cakir, E. Turlay, P. M. Tuts, A. Tykhonov, M. Tylmad, M. Tyndel, D. Typaldos, H. Tyrvainen, G. Tzanakos, K. Uchida, I. Ueda, R. Ueno, M. Ugland, M. Uhlenbrock, M. Uhrmacher, F. Ukegawa, G. Unal, D. G. Underwood, A. Undrus, G. Unel, Y. Unno, D. Urbaniec, E. Urkovsky, P. Urquijo, P. Urrejola, G. Usai, M. Uslenghi, L. Vacavant, V. Vacek, B. Vachon, S. Vahsen, C. Valderanis, J. Valenta, P. Valente, S. Valentinetti, S. Valkar, E. Valladolid Gallego, S. Vallecorsa, J. A. Valls Ferrer, H. van der Graaf, E. van der Kraaij, E. van der Poel, D. van der Ster, B. Van Eijk, N. van Eldik, P. van Gemmeren, Z. van Kesteren, I. van Vulpen, W. Vandelli, G. Vandoni, A. Vaniachine, P. Vankov, F. Vannucci, F. VarelaRodriguez, R. Vari, E. W. Varnes, D. Varouchas, A. Vartapetian, K. E. Varvell, V. I. Vassilakopoulos, F. Vazeille, G. Vegni, J. J. Veillet, C. Vellidis, F. Veloso, R. Veness, S. Veneziano, A. Ventura, D. Ventura, S. Ventura, M. Venturi, N. Venturi, V. Vercesi, M. Verducci, W. Verkerke, J. C. Vermeulen, L. Vertogardov, A. Vest, M. C. Vetterli, I. Vichou, T. Vickey, G. H. A. Viehhauser, S. Viel, M. Villa, M. Villaplana Perez, E. Vilucchi, M. G. Vincter, E. Vinek, V. B. Vinogradov, M. Virchaux, S. Viret, J. Virzi, A. Vitale, O. Vitells, I. Vivarelli, F. Vives Vaque, S. Vlachos, M. Vlasak, N. Vlasov, A. Vogel, P. Vokac, M. Volpi, G. Volpini, H. von der Schmitt, J. von Loeben, H. von Radziewski, E. von Toerne, V. Vorobel, A. P. Vorobiev, V. Vorwerk, M. Vos, R. Voss, T. T. Voss, J. H. Vossebeld, A. S. Vovenko, N. Vranjes, M. Vranjes Milosavljevic, V. Vrba, M. Vreeswijk, T. Vu Anh, R. Vuillermet, I. Vukotic, W. Wagner, P. Wagner, H. Wahlen, J. Wakabayashi, J. Walbersloh, S. Walch, J. Walder, R. Walker, W. Walkowiak, R. Wall, P. Waller, C. Wang, H. Wang, J. Wang, J. C. Wang, S. M. Wang, A. Warburton, C. P. Ward, M. Warsinsky, P. M. Watkins, A. T. Watson, M. F. Watson, G. Watts, S. Watts, A. T. Waugh, B. M. Waugh, J. Weber, M. Weber, M. S. Weber, P. Weber, A. R. Weidberg, J. Weingarten, C. Weiser, H. Wellenstein, P. S. Wells, M. Wen, T. Wenaus, S. Wendler, Z. Weng, T. Wengler, S. Wenig, N. Wermes, M. Werner, P. Werner, M. Werth, M. Wessels, K. Whalen, S. J. Wheeler-Ellis, S. P. Whitaker, A. White, M. J. White, S. R. Whitehead, D. Whiteson, D. Whittington, F. Wicek, D. Wicke, F. J. Wickens, W. Wiedenmann, M. Wielers, P. Wienemann, C. Wiglesworth, L. A. M. Wiik, A. Wildauer, M. A. Wildt, I. Wilhelm, H. G. Wilkens, J. Z. Will, E. Williams, H. H. Williams, W. Willis, S. Willocq, J. A. Wilson, M. G. Wilson, A. Wilson, I. Wingerter-Seez, S. Winkelmann, F. Winklmeier, M. Wittgen, M. W. Wolter, H. Wolters, G. Wooden, B. K. Wosiek, J. Wotschack, M. J. Woudstra, K. Wraight, C. Wright, B. Wrona, S. L. Wu, X. Wu, Y. Wu, E. Wulf, R. Wunstorf, B. M. Wynne, L. Xaplanteris, S. Xella, S. Xie, Y. Xie, C. Xu, D. Xu, G. Xu, B. Yabsley, M. Yamada, A. Yamamoto, K. Yamamoto, S. Yamamoto, T. Yamamura, J. Yamaoka, T. Yamazaki, Y. Yamazaki, Z. Yan, H. Yang, S. Yang, U. K. Yang, Y. Yang, Z. Yang, S. Yanush, W.-M. Yao, Y. Yao, Y. Yasu, J. Ye, S. Ye, M. Yilmaz, R. Yoosoofmiya, K. Yorita, R. Yoshida, C. Young, S. Youssef, D. Yu, J. Yu, L. Yuan, A. Yurkewicz, V. G. Zaets, R. Zaidan, A. M. Zaitsev, Z. Zajacova, Yo. K. Zalite, L. Zanello, P. Zarzhitsky, A. Zaytsev, M. Zdrazil, C. Zeitnitz, M. Zeller, P. F. Zema, A. Zemla, C. Zendler, A. V. Zenin, O. Zenin, T. Ženiš, Z. Zenonos, S. Zenz, D. Zerwas, G. Zevi della Porta, Z. Zhan, D. Zhang, H. Zhang, J. Zhang, X. Zhang, Z. Zhang, L. Zhao, T. Zhao, Z. Zhao, A. Zhemchugov, S. Zheng, J. Zhong, B. Zhou, N. Zhou, Y. Zhou, C. G. Zhu, H. Zhu, Y. Zhu, X. Zhuang, V. Zhuravlov, D. Zieminska, B. Zilka, R. Zimmermann, S. Zimmermann, M. Ziolkowski, R. Zitoun, L. Živković, V. V. Zmouchko, G. Zobernig, A. Zoccoli, Y. Zolnierowski, A. Zsenei, M. zur Nedden, V. Zutshi, and L. Zwalinski
Subjects: Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract Measurements of luminosity obtained using the ATLAS detector during early running of the Large Hadron Collider (LHC) at $\sqrt{s} = 7$ TeV are presented. The luminosity is independently determined using several detectors and multiple algorithms, each having different acceptances, systematic uncertainties and sensitivity to background. The ratios of the luminosities obtained from these methods are monitored as a function of time and of μ, the average number of inelastic interactions per bunch crossing. Residual time- and μ-dependence between the methods is less than 2% for 0
Published: 2011
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33. INFLUENCE OF STRAIN AGEING ON CHARACTERISTICS OF DIFFERENT ARTICLES OF STEEL

Author: E. D. Shcherbakov, V. P. Lapin, and O. R. Essenson
Subjects: Mining engineering. Metallurgy, TN1-997
Abstract: The influence of strain aging on characteristics of different steel articles is shown.
Published: 2010
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34. The role of second generation Bruton tyrosine kinase inhibitors in the treatment of chronic lymphocytic leukemia. Resolution

Author: T. I. Pospelova, Tatyana E. Bialik, EA Stadnik, Natalya N. Glonina, Nadezhda V. Medvedeva, Irina V. Poddubnaya, Evgeniy Aleksandrovich Nikitin, V A Lapin, K D Kaplanov, Olga B. Kalashnikova, Natalya B. Mikhailova, and Moiseeva Tn
Subjects: Oncology, Cancer Research, medicine.medical_specialty, bruton tyrosine kinase inhibitors, medicine.medical_treatment, Chronic lymphocytic leukemia, Disease, lcsh:RC254-282, Targeted therapy, chemistry.chemical_compound, ibrutinib, immune system diseases, hemic and lymphatic diseases, Internal medicine, medicine, Bruton's tyrosine kinase, biology, business.industry, acalabrutinib, Standard treatment, targeted therapy, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, immunochemotherapy, Leukemia, chemistry, Ibrutinib, biology.protein, chronic lymphocytic leukemia, Acalabrutinib, business
Abstract: Chronic lymphocytic leukemia (CLL) is the most common type of adult leukemia, with incidence rate of 4: 100 thousand per year, according to European data. CLL remains an incurable disease, with most patients over 60 years old. Immunochemotherapy schemes today remain the standard treatment approach for CLL. The advent of novel molecules expands possibilities of treating this disease. Targeted therapy with small molecule inhibitors of Bruton tyrosine kinase (BTK) occupies an important place in the treatment of patients with CLL, both for first-line therapy and for treatment of relapses. The drug acalabrutinib as a highly selective new generation of BTK inhibitor can be considered as an efficient and safe option for first-line therapy and for treatment of the disease relapse in patients with CLL, especially in patients with comorbidity, including cardiovascular diseases (CDV) or risk factors for CVD.
Published: 2020
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35. On the Global Implicit Criterion of a Fracture Propagation Under Mixed Load

Author: V. N. Lapin and A. A. Fomina
Subjects: Local symmetry, Applied Mathematics, Mathematical analysis, Minimization problem, Zero (complex analysis), Fracture (geology), Value (computer science), Interval (mathematics), Fracture propagation, Industrial and Manufacturing Engineering, Stress intensity factor, Mathematics
Abstract: Validation is carried out of the previously proposed implicit criterion for choosing the direction of a fracture propagation under the complex loading characterized by the presence of all three modes of the stress intensity factors KI, KII, and KIII. The criterion is based on the principle of local symmetry according to which the fracture propagates in the direction providing the zero values of the factors of both mixed modes KII and KIII. Since in the general case the two conditions cannot be satisfied simultaneously, the criterion is formulated as a minimization problem for a functional that contains the sum of the values of the mixed modes integrated along the entire front of the fracture. The formulation of the criterion includes some parameter that describes the effect of each of the mixed modes; the value of this parameter should be chosen by using the experimental data. Based on two fracture propagation experiments with complex mixed loading, validation of the criterion is carried out and some estimates are given for the interval of the best value of the weight parameter.
Published: 2019
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36. Influence of the ceramic powder morphology and forming conditions on the optical transmittance of YAG:Yb ceramics

Author: L.M. Mitrofanenko, Alexander A. Kravtsov, D.S. Vakalov, D.S. Kuleshov, F.F. Malyavin, E.V. Medyanik, L.V. Tarala, Marina S. Shama, S. V. Kuznetsov, V.S. Ziryanov, V. A. Lapin, E.A. Evtushenko, V.A. Tarala, and I.S. Chikulina
Subjects: 010302 applied physics, Pressing, Materials science, Morphology (linguistics), Process Chemistry and Technology, Dispersity, Green body, 02 engineering and technology, 021001 nanoscience & nanotechnology, 01 natural sciences, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, visual_art, Specific surface area, 0103 physical sciences, Materials Chemistry, Ceramics and Composites, Transmittance, visual_art.visual_art_medium, Relative density, Ceramic, Composite material, 0210 nano-technology
Abstract: The influence of the dispersity and morphology of ceramic powders on the characteristics of green bodies and the optical transmittance of YAG:Yb (20 at%) ceramics was considered. The effect of the specific surface area on the relative density of compacts was studied. An increase in the specific surface area from 1.45 to 12.38 m2/g led to a decrease in the relative density of green body compacts from 52% to 38% under the fixed uniaxial pressure of 50 MPa. An increase in the uniaxial pressing value up to 150 MPa provided a maximum increase of the optical transmission of ceramics. However, an increase in the specific surface area and uniaxial pressure led to the appearance of macrodefects in ceramic samples. Cold isostatic pressing at 200 MPa after uniaxial pressing at 50 MPa resulted in an increase of optical transparency and the elimination of the macrodefect formation in ceramics. Dispersity and morphology of ceramic powders have a significant effect on the optical transparency of ceramics. Forming conditions had insignificant influence on optical characteristics. Highly transparent YAG:Yb ceramics with 80% transmittance were developed.
Published: 2019
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37. Thermal Surface Interface for High-Power Arsenide–Gallium Heterostructure FETs

Author: V. M. Lukashin, N. K. Pristupchik, M. I. Lopin, I. V. Kulikova, V. G. Lapin, L. V. Manchenko, V. G. Kalina, A. D. Zakurdaev, and A. B. Pashkovskii
Subjects: 010302 applied physics, Materials science, Physics and Astronomy (miscellaneous), business.industry, Thermal resistance, Transistor, chemistry.chemical_element, Heterojunction, Dielectric, engineering.material, 01 natural sciences, 010305 fluids & plasmas, Arsenide, law.invention, chemistry.chemical_compound, chemistry, Coating, law, 0103 physical sciences, engineering, Optoelectronics, Gallium, business, Overheating (electricity)
Abstract: Application of heat-conducting coatings for cooling of high-power FETs based on heterostructures with arsenide–gallium substrate is theoretically analyzed. When the basic technology for manufacturing of transistors is employed in the absence of additional efforts aimed at a decrease in the thermal resistance of the substrate, the application of an additional thermal interface that represents a heat-conducting dielectric coating makes it possible to substantially decrease the overheating of the transistor channel. A several-fold decrease in such overheating can be reached using variations in the thickness of the coating and modification of the transistor structure and working regimes.
Published: 2019
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38. Implementation of planar 3D model of hydraulic fracture in rock with layered compressive stress

Author: V. N. Lapin
Published: 2021
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39. Generation of high frequency trains of chirped soliton-like pulses in inhomogeneous and cascaded active fiber configurations

Author: Igor O. Zolotovskii, Sergei Popov, V. A. Lapin, D. I. Sementsov, and Andrei A. Fotiadi
Subjects: Physics, Optical fiber, business.industry, Terahertz radiation, Physics::Optics, 01 natural sciences, Instability, Atomic and Molecular Physics, and Optics, Electronic, Optical and Magnetic Materials, law.invention, 010309 optics, Nonlinear system, Optics, Cascade, Homogeneous, law, 0103 physical sciences, Pulse wave, Train, Electrical and Electronic Engineering, Physical and Theoretical Chemistry, 010306 general physics, business
Abstract: We present a theoretical formalism of description of soliton-like pulse generation in longitudinally inhomogeneous active optical fibers. Dynamics of the wave packet during the nonlinear stage of the modulation instability is described for fibers with distributed gain and group velocity dispersion profiles. Generation of pico- and sub-picosecond pulse trains operating in THz repetition range from quasi-continuous pump wave is simulated for fibers of different inhomogeneity and for cascade fiber configurations comprising homogeneous and inhomogeneous segments. Pulse train generation is shown to occur in resonant manner once the gain and GDV distributed fiber profiles are perfectly matched.
Published: 2018
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40. Generation of subpicosecond pulses due to the development of modulation instability of whispering-gallery-mode wave packets in an optical waveguide with a travelling refractive-index wave

Author: V. A. Lapin, Andrei A. Fotiadi, Dmitry A. Korobko, D. I. Sementsov, Igor O. Zolotovskii, P. P. Mironov, and M. S. Yavtushenko
Subjects: Physics, business.industry, Wave packet, Statistical and Nonlinear Physics, Instability, Atomic and Molecular Physics, and Optics, Electronic, Optical and Magnetic Materials, Optics, Modulation, Development (differential geometry), Electrical and Electronic Engineering, Whispering-gallery wave, business, Refractive index
Published: 2018
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41. Features of the Upsurge in Drift Velocity of Electrons in DA-pHEMT

Author: V. M. Lukashin, Ya. B. Martynov, S. I. Novikov, A. B. Pashkovskii, and V. G. Lapin
Subjects: 010302 applied physics, Physics, Drift velocity, Physics and Astronomy (miscellaneous), Condensed matter physics, Doping, Transistor, Heterojunction, 02 engineering and technology, Electron, High-electron-mobility transistor, Condensed Matter::Mesoscopic Systems and Quantum Hall Effect, 021001 nanoscience & nanotechnology, 01 natural sciences, law.invention, Condensed Matter::Materials Science, law, 0103 physical sciences, Phenomenological model, 0210 nano-technology, Quantum well
Abstract: A simple phenomenological model for estimating the upsurge in drift velocity of electrons in transistor heterostructures is proposed. This model is based on a self-consistent solution of Schrodinger and Poisson equations and the hydrodynamic system of equations of energy and momentum conservation. It is demonstrated that the conditions in the layer channel of DA-pHEMT structures with additional potential barriers, which are produced by donor–acceptor doping and enhance the localization of hot electrons, are even more conducive to reducing the time of flight of electrons under the gate than those established in heterostructures with deeper quantum wells produced by increasing the conduction band offset at the heterojunction interface.
Published: 2018
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42. Instability of Interaction of a Triplet of Internal Gravity Waves under Conditions of a Constant Wind and Nonlinear Desynchronism

Author: V. G. Lapin, N. V. Bakhmet’eva, and G. I. Grigoriev
Subjects: Physics, 010504 meteorology & atmospheric sciences, Mechanics, 01 natural sciences, Stability (probability), Instability, Internal gravity wave, Atmosphere, Third order, Nonlinear system, Physics::Space Physics, 0103 physical sciences, Astrophysics::Earth and Planetary Astrophysics, Soliton, Physical and Theoretical Chemistry, Constant (mathematics), 010303 astronomy & astrophysics, Physics::Atmospheric and Oceanic Physics, 0105 earth and related environmental sciences
Abstract: The interaction of internal gravity waves in the Earth’s atmosphere is considered in the presence of a horizontal altitude-independent wind. Taking into account nonlinear terms, up to the third order inclusive, it was possible to determine the form and conditions of existence of the soliton and nonlinear periodic solutions. The issue of the stability of the solutions is examined.
Published: 2018
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43. An implicit criterion of fracture growth direction for 3D simulation of hydraulic fracture propagation

Author: V N Lapin and Sergey Cherny
Subjects: Mathematical analysis, Zero (complex analysis), 02 engineering and technology, Function (mathematics), 01 natural sciences, Fracture propagation, 010101 applied mathematics, Stress (mechanics), 020303 mechanical engineering & transports, Hydraulic fracturing, 0203 mechanical engineering, Fracture (geology), Point (geometry), 0101 mathematics, Stress intensity factor, Earth-Surface Processes, Mathematics
Abstract: Validation of the previously proposed implicit criterion of fracture propagation was carried out. The implicit criterion at each step of the propagation considers the rock stress state both before and after the propagation. It is based on the assumption that the fracture tends to propagate in the direction where II and III modes of stress intensity factor (SIF) are zero. Since in most cases both conditions cannot be satisfied simultaneously, the values of the SIF modes II and III are combined in one function and are integrated along the whole front. A few possible propagation directions are considered at each step of the propagation and the one is chosen to provide the minimum of the integral. The criterion parameters was chosen using the comparison with experiment results and semi analytical formulas obtained from three point bend test with twisted fracture.
Published: 2018
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44. Non-Intensive Continuous Treatment with a Tyrosine Kinase Inhibitor (TKI) Followed By Allo-HSCT Is an Effective Therapeutic Strategy for Adult Ph-Positive Acute Lymphoblastic Leukemia: Outcomes of the Russian Prospective Multicenter RALL Study

Author: Julia Chabaeva, Zalina Akhmerzaeva, Sergey N. Bondarenko, Elena N. Parovichnikova, Olga Samoylova, Tatiana Konstantinova, Olga A. Gavrilina, Vera V. Troitskaya, V A Lapin, Larisa A. Kuzmina, Valery G. Savchenko, and Maria Grishunina
Subjects: Oncology, medicine.medical_specialty, medicine.drug_class, business.industry, Immunology, Allo hsct, Cell Biology, Hematology, Biochemistry, Tyrosine-kinase inhibitor, Continuous treatment, Ph-positive acute lymphoblastic leukemia, Internal medicine, medicine, business, Therapeutic strategy
Abstract: Introduction. As Ph-positive (Ph+) ALL in adults remains less favorable in prognosis than other ALL, and by expert opinion needs non-intensive chemotherapy protocols and new generation TKI with the majority of pts undergoing allo-HSCT, the results of treatment based on the different approach: de-escalated but continuous treatment with the change of TKI according to the molecular response and allo-HSCT may be of interest and provide new insights to the treatment of Ph+ ALL. Aim. To evaluate survival and outcomes in different risk groups in pts with Ph+ ALL in the RALL-study (Ph+ALL-2009, Ph+ALL-2012 and Ph+ALL-2012m protocols). Patients and methods. Between January 2010 and June 2021, 74 new Ph+ ALL cases were diagnosed in 6 centers of the RALL-group and 63 of them were evaluable for analysis (median age 37 years (17-73), m/f 32(43%)/42(57%), CNS disease in 13(21%) pts, WBC>30*10 9/l in 27(43%) pts, bcr/abl transcript p190/p210/p190+210 in 31(60%)/12(23%)/9(17%) cases). Standard cytogenetic was performed in all 63 pts, 1 had no mitosis, 6(10%) monosomy 7 and 2 (3%) complex karyotypes were detected. All pts were treated according to RALL protocols with continuous Imatinib. Ph+ALL-2009 protocol included 600 mg Imatinib with prednisone, VNCR, L-asp, Dauno, Cph, followed by 6-MP and MTX. Imatinib had to be changed to Dasatinib (140 mg) after non-achievement of molecular complete response (MolCR) on day 70. MolCR was defined as bcr/abl chimeric transcript Results. Hematological complete remission (CR) was achieved in 60 (95%) of 63 pts (1 early death and 2 refractory cases occurred). On day 70, MolCR was achieved in 21(38%) of 56 pts. Death on therapy in CR (within 5 months of induction/consolidation) was registered in 4 (6%) cases. The major causes of the non-relapsed mortality in unrelated allo-HSCT (n=9) were aGVHD and severe infections, at a median +4 months after HSCT. The 5-year overall survival (OS) and disease-free survival (DFS) for all 63 pts were 58% and 45%, respectively. The long-term outcome on different protocols (Ph+ALL-2009, Ph+ALL-2012 and Ph+ALL-2012m) were similar: 3-year OS - 55% vs 51% vs 75% (p=0,27), 3-year DFS - 56% vs 44% vs 50% (p=0,54), respectively. The 5-year OS was 65% vs 61% (p=0,84), and DFS was 57% vs 31% (p=0,24) in transplanted vs non-transplanted patients by landmark analysis with a median 5,3 month of CR. Landmark analysis of 5-year OS for transplanted and non-transplanted pts depending on age showed no significant difference for both groups: >45y 40% vs 80%; and ≤45y 70% vs 49%, respectively (p=0,1625), although data for 5-year OS was still not mature at the time of analysis. DFS was significantly different in transplanted vs. non-transplanted pts: >45y 40% vs 71%; ≤45y 61% vs 0%; respectively (p=0,0439). In a multivariate analysis for Ph+ ALL among common risk factors (age > 45y, WBC>30, LDH>2N, immunophenotype, late MolCR >70d, CNS leukemia) WBC>30, HSCT were significant risk factors for OS and DFS. Conclusions. Our data demonstrate that de-intensification of chemotherapy does not affect the efficacy of Ph+ ALL therapy in the era of TKIs. We confirmed that patients older than 45y old could be treated by chemotherapy with TKI (new generation TKI if needed) only, but all pts younger than 45y should be considered for HSCT. Figure 1 Figure 1. Disclosures No relevant conflicts of interest to declare.
Published: 2021
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45. Search for contact interactions in dimuon events fromppcollisions ats=7 TeVwith the ATLAS detector

Author: G. Aad, B. Abbott, J. Abdallah, A. A. Abdelalim, A. Abdesselam, O. Abdinov, B. Abi, M. Abolins, H. Abramowicz, H. Abreu, E. Acerbi, B. S. Acharya, D. L. Adams, T. N. Addy, J. Adelman, M. Aderholz, S. Adomeit, P. Adragna, T. Adye, S. Aefsky, J. A. Aguilar-Saavedra, M. Aharrouche, S. P. Ahlen, F. Ahles, A. Ahmad, M. Ahsan, G. Aielli, T. Akdogan, T. P. A. Åkesson, G. Akimoto, A. V. Akimov, A. Akiyama, M. S. Alam, M. A. Alam, S. Albrand, M. Aleksa, I. N. Aleksandrov, F. Alessandria, C. Alexa, G. Alexander, G. Alexandre, T. Alexopoulos, M. Alhroob, M. Aliev, G. Alimonti, J. Alison, M. Aliyev, P. P. Allport, S. E. Allwood-Spiers, J. Almond, A. Aloisio, R. Alon, A. Alonso, M. G. Alviggi, K. Amako, P. Amaral, C. Amelung, V. V. Ammosov, A. Amorim, G. Amorós, N. Amram, C. Anastopoulos, T. Andeen, C. F. Anders, K. J. Anderson, A. Andreazza, V. Andrei, M-L. Andrieux, X. S. Anduaga, A. Angerami, F. Anghinolfi, N. Anjos, A. Annovi, A. Antonaki, M. Antonelli, S. Antonelli, A. Antonov, J. Antos, F. Anulli, S. Aoun, L. Aperio Bella, R. Apolle, G. Arabidze, I. Aracena, Y. Arai, A. T. H. Arce, J. P. Archambault, S. Arfaoui, J-F. Arguin, E. Arik, M. Arik, A. J. Armbruster, O. Arnaez, C. Arnault, A. Artamonov, G. Artoni, D. Arutinov, S. Asai, R. Asfandiyarov, S. Ask, B. Åsman, L. Asquith, K. Assamagan, A. Astbury, A. Astvatsatourov, G. Atoian, B. Aubert, B. Auerbach, E. Auge, K. Augsten, M. Aurousseau, N. Austin, R. Avramidou, D. Axen, C. Ay, G. Azuelos, Y. Azuma, M. A. Baak, G. Baccaglioni, C. Bacci, A. M. Bach, H. Bachacou, K. Bachas, G. Bachy, M. Backes, M. Backhaus, E. Badescu, P. Bagnaia, S. Bahinipati, Y. Bai, D. C. Bailey, T. Bain, J. T. Baines, O. K. Baker, M. D. Baker, S. Baker, F. Baltasar Dos Santos Pedrosa, E. Banas, P. Banerjee, Sw. Banerjee, D. Banfi, A. Bangert, V. Bansal, H. S. Bansil, L. Barak, S. P. Baranov, A. Barashkou, A. Barbaro Galtieri, T. Barber, E. L. Barberio, D. Barberis, M. Barbero, D. Y. Bardin, T. Barillari, M. Barisonzi, T. Barklow, N. Barlow, B. M. Barnett, R. M. Barnett, A. Baroncelli, A. J. Barr, F. Barreiro, J. Barreiro Guimarães da Costa, P. Barrillon, R. Bartoldus, A. E. Barton, D. Bartsch, V. Bartsch, R. L. Bates, L. Batkova, J. R. Batley, A. Battaglia, M. Battistin, G. Battistoni, F. Bauer, H. S. Bawa, B. Beare, T. Beau, P. H. Beauchemin, R. Beccherle, P. Bechtle, H. P. Beck, M. Beckingham, K. H. Becks, A. J. Beddall, A. Beddall, S. Bedikian, V. A. Bednyakov, C. P. Bee, M. Begel, S. Behar Harpaz, P. K. Behera, M. Beimforde, C. Belanger-Champagne, P. J. Bell, W. H. Bell, G. Bella, L. Bellagamba, F. Bellina, M. Bellomo, A. Belloni, O. Beloborodova, K. Belotskiy, O. Beltramello, S. Ben Ami, O. Benary, D. Benchekroun, C. Benchouk, M. Bendel, B. H. Benedict, N. Benekos, Y. Benhammou, D. P. Benjamin, M. Benoit, J. R. Bensinger, K. Benslama, S. Bentvelsen, D. Berge, E. Bergeaas Kuutmann, N. Berger, F. Berghaus, E. Berglund, J. Beringer, K. Bernardet, P. Bernat, R. Bernhard, C. Bernius, T. Berry, A. Bertin, F. 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Schöning, M. Schott, D. Schouten, J. Schovancova, M. Schram, C. Schroeder, N. Schroer, S. Schuh, G. Schuler, J. Schultes, H.-C. Schultz-Coulon, H. Schulz, J. W. Schumacher, M. Schumacher, B. A. Schumm, Ph. Schune, C. Schwanenberger, A. Schwartzman, Ph. Schwemling, R. Schwienhorst, R. Schwierz, J. Schwindling, W. G. Scott, J. Searcy, E. Sedykh, E. Segura, S. C. Seidel, A. Seiden, F. Seifert, J. M. Seixas, G. Sekhniaidze, D. M. Seliverstov, B. Sellden, G. Sellers, M. Seman, N. Semprini-Cesari, C. Serfon, L. Serin, R. Seuster, H. Severini, M. E. Sevior, A. Sfyrla, E. Shabalina, M. Shamim, L. Y. Shan, J. T. Shank, Q. T. Shao, M. Shapiro, P. B. Shatalov, L. Shaver, C. Shaw, K. Shaw, D. Sherman, P. Sherwood, A. Shibata, S. Shimizu, M. Shimojima, T. Shin, A. Shmeleva, M. J. Shochet, D. Short, M. A. Shupe, P. Sicho, A. Sidoti, A. Siebel, F. Siegert, J. Siegrist, Dj. Sijacki, O. Silbert, J. Silva, Y. Silver, D. Silverstein, S. B. Silverstein, V. Simak, O. Simard, Lj. Simic, S. Simion, B. Simmons, M. Simonyan, P. Sinervo, N. B. Sinev, V. Sipica, G. Siragusa, A. N. Sisakyan, S. Yu. Sivoklokov, J. Sjölin, T. B. Sjursen, L. A. Skinnari, K. Skovpen, P. Skubic, N. Skvorodnev, M. Slater, T. Slavicek, K. Sliwa, T. J. Sloan, J. Sloper, V. Smakhtin, S. Yu. Smirnov, L. N. Smirnova, O. Smirnova, B. C. Smith, D. Smith, K. M. Smith, M. Smizanska, K. Smolek, A. A. Snesarev, S. W. Snow, J. Snow, J. Snuverink, S. Snyder, M. Soares, R. Sobie, J. Sodomka, A. Soffer, C. A. Solans, M. Solar, J. Solc, E. Soldatov, U. Soldevila, E. Solfaroli Camillocci, A. A. Solodkov, O. V. Solovyanov, J. Sondericker, N. Soni, V. Sopko, B. Sopko, M. Sorbi, M. Sosebee, A. Soukharev, S. Spagnolo, F. Spanò, R. Spighi, G. Spigo, F. Spila, E. Spiriti, R. Spiwoks, M. Spousta, T. Spreitzer, B. Spurlock, R. D. St. Denis, T. Stahl, J. Stahlman, R. Stamen, E. Stanecka, R. W. Stanek, C. Stanescu, S. Stapnes, E. A. Starchenko, J. Stark, P. Staroba, P. Starovoitov, A. Staude, P. Stavina, G. Stavropoulos, G. Steele, P. Steinbach, P. Steinberg, I. Stekl, B. Stelzer, H. J. Stelzer, O. Stelzer-Chilton, H. Stenzel, K. Stevenson, G. A. Stewart, J. A. Stillings, T. Stockmanns, M. C. Stockton, K. Stoerig, G. Stoicea, S. Stonjek, P. Strachota, A. R. Stradling, A. Straessner, J. Strandberg, S. Strandberg, A. Strandlie, M. Strang, E. Strauss, M. Strauss, P. Strizenec, R. Ströhmer, D. M. Strom, J. A. Strong, R. Stroynowski, J. Strube, B. Stugu, I. Stumer, J. Stupak, P. Sturm, D. A. Soh, D. Su, HS. Subramania, A. Succurro, Y. Sugaya, T. Sugimoto, C. Suhr, K. Suita, M. Suk, V. V. Sulin, S. Sultansoy, T. Sumida, X. Sun, J. E. Sundermann, K. Suruliz, S. Sushkov, G. Susinno, M. R. Sutton, Y. Suzuki, M. Svatos, Yu. M. Sviridov, S. Swedish, I. Sykora, T. Sykora, B. Szeless, J. Sánchez, D. Ta, K. Tackmann, A. Taffard, R. Tafirout, A. Taga, N. Taiblum, Y. Takahashi, H. Takai, R. Takashima, H. Takeda, T. Takeshita, M. Talby, A. Talyshev, M. C. Tamsett, J. Tanaka, R. Tanaka, S. Tanaka, Y. Tanaka, K. Tani, N. Tannoury, G. P. Tappern, S. Tapprogge, D. Tardif, S. Tarem, F. Tarrade, G. F. Tartarelli, P. Tas, M. Tasevsky, E. Tassi, M. Tatarkhanov, C. Taylor, F. E. Taylor, G. N. Taylor, W. Taylor, M. Teixeira Dias Castanheira, P. Teixeira-Dias, K. K. Temming, H. Ten Kate, P. K. Teng, S. Terada, K. Terashi, J. Terron, M. Terwort, M. Testa, R. J. Teuscher, J. Thadome, J. Therhaag, T. Theveneaux-Pelzer, M. Thioye, S. Thoma, J. P. Thomas, E. N. Thompson, P. D. Thompson, A. S. Thompson, E. Thomson, M. Thomson, R. P. Thun, T. Tic, V. O. Tikhomirov, Y. A. Tikhonov, C. J. W. P. Timmermans, P. Tipton, F. J. Tique Aires Viegas, S. Tisserant, J. Tobias, B. Toczek, T. Todorov, S. Todorova-Nova, B. Toggerson, J. Tojo, S. Tokár, K. Tokunaga, K. Tokushuku, K. Tollefson, M. Tomoto, L. Tompkins, K. Toms, G. Tong, A. Tonoyan, C. Topfel, N. D. Topilin, I. Torchiani, E. Torrence, E. Torró Pastor, J. Toth, F. Touchard, D. R. Tovey, D. Traynor, T. Trefzger, J. Treis, L. Tremblet, A. Tricoli, I. M. Trigger, S. Trincaz-Duvoid, T. N. Trinh, M. F. Tripiana, N. Triplett, W. Trischuk, A. Trivedi, B. Trocmé, C. Troncon, M. Trottier-McDonald, A. Trzupek, C. Tsarouchas, J. C-L. Tseng, M. Tsiakiris, P. V. Tsiareshka, D. Tsionou, G. Tsipolitis, V. Tsiskaridze, E. G. Tskhadadze, I. I. Tsukerman, V. Tsulaia, J.-W. Tsung, S. Tsuno, D. Tsybychev, A. Tua, J. M. Tuggle, M. Turala, D. Turecek, I. Turk Cakir, E. Turlay, R. Turra, P. M. Tuts, A. Tykhonov, M. Tylmad, M. Tyndel, H. Tyrvainen, G. Tzanakos, K. Uchida, I. Ueda, R. Ueno, M. Ugland, M. Uhlenbrock, M. Uhrmacher, F. Ukegawa, G. Unal, D. G. Underwood, A. Undrus, G. Unel, Y. Unno, D. Urbaniec, E. Urkovsky, P. Urrejola, G. Usai, M. Uslenghi, L. Vacavant, V. Vacek, B. Vachon, S. Vahsen, J. Valenta, P. Valente, S. Valentinetti, S. Valkar, E. Valladolid Gallego, S. Vallecorsa, J. A. Valls Ferrer, H. van der Graaf, E. van der Kraaij, R. Van Der Leeuw, E. van der Poel, D. van der Ster, B. Van Eijk, N. van Eldik, P. van Gemmeren, Z. van Kesteren, I. van Vulpen, W. Vandelli, G. Vandoni, A. Vaniachine, P. Vankov, F. Vannucci, F. Varela Rodriguez, R. Vari, E. W. Varnes, D. Varouchas, A. Vartapetian, K. E. Varvell, V. I. Vassilakopoulos, F. Vazeille, G. Vegni, J. J. Veillet, C. Vellidis, F. Veloso, R. Veness, S. Veneziano, A. Ventura, D. Ventura, M. Venturi, N. Venturi, V. Vercesi, M. Verducci, W. Verkerke, J. C. Vermeulen, A. Vest, M. C. Vetterli, I. Vichou, T. Vickey, G. H. A. Viehhauser, S. Viel, M. Villa, M. Villaplana Perez, E. Vilucchi, M. G. Vincter, E. Vinek, V. B. Vinogradov, M. Virchaux, S. Viret, J. Virzi, A. Vitale, O. Vitells, M. Viti, I. Vivarelli, F. Vives Vaque, S. Vlachos, M. Vlasak, N. Vlasov, A. Vogel, P. Vokac, G. Volpi, M. Volpi, G. Volpini, H. von der Schmitt, J. von Loeben, H. von Radziewski, E. von Toerne, V. Vorobel, A. P. Vorobiev, V. Vorwerk, M. Vos, R. Voss, T. T. Voss, J. H. Vossebeld, N. Vranjes, M. Vranjes Milosavljevic, V. Vrba, M. Vreeswijk, T. Vu Anh, R. Vuillermet, I. Vukotic, W. Wagner, P. Wagner, H. Wahlen, J. Wakabayashi, J. Walbersloh, S. Walch, J. Walder, R. Walker, W. Walkowiak, R. Wall, P. Waller, C. Wang, H. Wang, J. Wang, J. C. Wang, R. Wang, S. M. Wang, A. Warburton, C. P. Ward, M. Warsinsky, P. M. Watkins, A. T. Watson, M. F. Watson, G. Watts, S. Watts, A. T. Waugh, B. M. Waugh, J. Weber, M. Weber, M. S. Weber, P. Weber, A. R. Weidberg, P. Weigell, J. Weingarten, C. Weiser, H. Wellenstein, P. S. Wells, M. Wen, T. Wenaus, S. Wendler, Z. Weng, T. Wengler, S. Wenig, N. Wermes, M. Werner, P. Werner, M. Werth, M. Wessels, C. Weydert, K. Whalen, S. J. Wheeler-Ellis, S. P. Whitaker, A. White, M. J. White, S. White, S. R. Whitehead, D. Whiteson, D. Whittington, F. Wicek, D. Wicke, F. J. Wickens, W. Wiedenmann, M. Wielers, P. Wienemann, C. Wiglesworth, L. A. M. Wiik, P. A. Wijeratne, A. Wildauer, M. A. Wildt, I. Wilhelm, H. G. Wilkens, J. Z. Will, E. Williams, H. H. Williams, W. Willis, S. Willocq, J. A. Wilson, M. G. Wilson, A. Wilson, I. Wingerter-Seez, S. Winkelmann, F. Winklmeier, M. Wittgen, M. W. Wolter, H. Wolters, G. Wooden, B. K. Wosiek, J. Wotschack, M. J. Woudstra, K. Wraight, C. Wright, B. Wrona, S. L. Wu, X. Wu, Y. Wu, E. Wulf, R. Wunstorf, B. M. Wynne, L. Xaplanteris, S. Xella, S. Xie, Y. Xie, C. Xu, D. Xu, G. Xu, B. Yabsley, M. Yamada, A. Yamamoto, K. Yamamoto, S. Yamamoto, T. Yamamura, J. Yamaoka, T. Yamazaki, Y. Yamazaki, Z. Yan, H. Yang, U. K. Yang, Y. Yang, Z. Yang, S. Yanush, W-M. Yao, Y. Yao, Y. Yasu, G. V. Ybeles Smit, J. Ye, S. Ye, M. Yilmaz, R. Yoosoofmiya, K. Yorita, R. Yoshida, C. Young, S. Youssef, D. Yu, J. Yu, L. Yuan, A. Yurkewicz, V. G. Zaets, R. Zaidan, A. M. Zaitsev, Z. Zajacova, Yo. K. Zalite, L. Zanello, P. Zarzhitsky, A. Zaytsev, C. Zeitnitz, M. Zeller, A. Zemla, C. Zendler, A. V. Zenin, O. Zenin, T. Ženiš, Z. Zenonos, S. Zenz, D. Zerwas, G. Zevi della Porta, Z. Zhan, D. Zhang, H. Zhang, J. Zhang, X. Zhang, Z. Zhang, L. Zhao, T. Zhao, Z. Zhao, A. Zhemchugov, S. Zheng, J. Zhong, B. Zhou, N. Zhou, Y. Zhou, C. G. Zhu, H. Zhu, Y. Zhu, X. Zhuang, V. Zhuravlov, D. Zieminska, R. Zimmermann, S. Zimmermann, M. Ziolkowski, R. Zitoun, L. Živković, V. V. Zmouchko, G. Zobernig, A. Zoccoli, Y. Zolnierowski, A. Zsenei, M. zur Nedden, V. Zutshi, and L. Zwalinski
Published: 2011
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46. A two-dimensional electron gas in donor–acceptor doped backward heterostructures

Author: A. B. Pashkovskii, V. M. Lukashin, V. G. Lapin, and S. I. Novikov
Subjects: 010302 applied physics, Materials science, Physics and Astronomy (miscellaneous), Condensed matter physics, Doping, Linearity, 020206 networking & telecommunications, Heterojunction, 02 engineering and technology, Condensed Matter::Mesoscopic Systems and Quantum Hall Effect, 01 natural sciences, Molecular physics, Condensed Matter::Materials Science, Transverse plane, Quantization (physics), 0103 physical sciences, 0202 electrical engineering, electronic engineering, information engineering, Rectangular potential barrier, Donor acceptor, Hot electron
Abstract: We propose a backward-diode heterostructure modified by a built-in acceptor-doped layer that forms an additional potential barrier decreasing the transverse transport of hot electrons to the substrate. According to calculations, this structure is characterized by (i) an energy difference between dimensional quantization levels that is several times the optical phonon energy in GaAs and (ii) increased linearity of transfer characteristics.
Published: 2017
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47. Generation of a sequence of frequency-modulated pulses in longitudinally inhomogeneous optical waveguides

Author: Igor O. Zolotovskii, D. A. Stolyarov, V. A. Lapin, and D. I. Sementsov
Subjects: Materials science, business.industry, Wave packet, Phase (waves), Physics::Optics, Radiation, Laser, 01 natural sciences, Waveguide (optics), Atomic and Molecular Physics, and Optics, Electronic, Optical and Magnetic Materials, law.invention, 010309 optics, Optics, law, Modulation, 0103 physical sciences, Dispersion (optics), Optoelectronics, Photonics, 010306 general physics, business, Nonlinear Sciences::Pattern Formation and Solitons
Abstract: The conditions for the generation and efficient amplification of frequency-modulated soliton-like wave packets in longitudinally inhomogeneous active optical waveguides have been studied. The possibility of forming a sequence of pico- and subpicosecond pulses from quasi-continuous radiation in active and passive optical waveguides with the group-velocity dispersion (GVD) changing over the waveguide length is considered. The behavior of a wave packet in the well-developed phase of modulation instability with a change in the waveguide inhomogeneity parameters has been investigated based on the numerical analysis.
Published: 2017
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48. The DA-pHEMT heterostructures for power microwave transistors

Author: V. G. Lapin, K. S. Zhuravlev, D. V. Gulyaev, A. K. Bakarov, A. I. Toropov, A. B. Pashkovskii, D. Yu Protasov, and V. M. Lukashin
Subjects: Power-added efficiency, Electron mobility, Electron density, Materials science, business.industry, Transistor, chemistry.chemical_element, Heterojunction, High-electron-mobility transistor, law.invention, chemistry, law, Optoelectronics, Beryllium, business, Power density
Abstract: The structural, transport and optical properties of DA-pHEMT heterostructures are considered. Despite the high 2DEG density (~4×1012 cm–2), parallel conductance is almost lacking in DA-pHEMT heterostructures: the electron density in the parallel conducting layer does not exceed 11% of the 2DEG density, and the electron mobility is lower than the 2DEG mobility by a factor of more than 2.5. It was determined that the beryllium concentration in the undoped InGaAs QW does not exceed 2×016 cm−3 in spite of the Be segregation from the p+-doped barriers during the epitaxy growth. The results of the development of powerful DA-pHEMT are presented. Transistors with a gate length of 0.4-0.5 μm and a total gate width of 0.8 mm at a frequency of 10 GHz have a gain of more than 9 dB, an output power density of more than 1.6 W/mm, a power added efficiency up to 50%.
Published: 2019
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49. The outcome of Ph-negative acute lymphoblastic leukemia presenting during pregnancy and treated on the Russian prospective multicenter trial RALL-2009

Author: Sergey M. Kulikov, Andrey N. Sokolov, A V Kokhno, T S Kaporskaya, Sergey A Makhinya, Yulia A. Chabaeva, Valery G. Savchenko, Larisa A. Kuzmina, Vera V. Troitskaya, Elena N. Parovichnikova, V A Lapin, Gennadiy M. Galstyan, G A Klyasova, Oleg A Latyshkevich, and Olga A. Gavrilina
Subjects: Adult, Cancer Research, medicine.medical_specialty, Adolescent, Lymphoblastic Leukemia, Disease-Free Survival, Russia, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, Internal medicine, Multicenter trial, Antineoplastic Combined Chemotherapy Protocols, Ph Negative, Humans, Medicine, Prospective Studies, business.industry, Hematology, Middle Aged, Precursor Cell Lymphoblastic Leukemia-Lymphoma, medicine.disease, Clinical trial, Oncology, 030220 oncology & carcinogenesis, Female, business, Pregnancy Complications, Neoplastic, Follow-Up Studies, 030215 immunology
Abstract: We report the data on 15 women who presented with Ph-negative acute lymphoblastic leukemia (ALL) between Jan 2009 until Dec 2016 and who were treated on the prospective multicenter RALL-2009 clinical trial. A comparison of their outcome was made with 129 non-pregnant females who entered the study and were treated by the same schedule. 10-years OS for pregnant and non-pregnant women was 58.6 % (29.6 %-85.0 %) and 43.3 % (32.1 %-58.8 %), DFS was 46 % (15.2 %-78.8 %) and 51 % (39.7 %-64.6 %); probability of relapse was 49 % (16.6 %-83.3 %) and 40.3 % (27.3 %-53.4 %), respectively. Twelve born during the study children are well and alive with a median age 5 years 2 months (2 years - 9 years). Though small, our study has shown some specific features of ALL diagnosed during pregnancy (more T-cell ALL, higher initial WBC, later responses) and has shown that the long-term outcome of women with ALL treated while pregnant is equivalent to female control patients treated on the same protocol.
Published: 2021
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50. Monitoring of a Seismic Isolation Object on Fluoroplastic Gaskets

Author: S E Yerzhanov and V A Lapin
Subjects: Vibration, Acceleration, Stochastic process, Gasket, Probabilistic logic, Base (geometry), Kinematics, Displacement (vector), Seismology, Geology
Abstract: A special testing ground is used to study the seismic insulating properties of buildings in Almaty. It includes buildings with conventional tape foundations with a cross-tape system, seismic-insulating kinematic and supports with fluoroplastic gaskets. The buildings are equipped with engineering-seismometric service stations (stations 20,21,22). The results of experimental studies of the house on fluoroplastic gaskets, performed in the late 80s, are analyzed. The results are compared with instrumental records during the earthquakes of May 31, 2012 and August 16, 2014. The period of the maximum of the spectrum coincides with the resonance at the initial stages of vibration tests 0.44-0.47 sec. Using a single-mass calculation scheme, taking into account the presence of dry friction forces, the calculation of the dynamic model of the building on the impact of an unsteady random process is performed. The median acceleration values at the base correspond to the data of the “Seismic Zoning Map of the Republic of Kazakhstan” for earthquakes with a recurrence of 475 years and 2475 years. Probabilistic estimates of displacement values at the support level are obtained.
Published: 2021
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