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This paper presents the evaluation of the use of insecticides in the agricultural production of the Kursk region. Studied territorial load dominant crop insecticides in a complex region for the period 2006-2013, were ranked the region in terms of territorial load insecticides. Estimated figures on theenvironmental risk of the formation of the pathology of the gastrointestinal tract of the adult population of the Kursk region in the intensive use of insecticides. Environmentally sensitive identified pathologies such as gastric ulcer and duodenal ulcers, gastritis and duodenitis, functional bowel disorders, diseases of the pancreas.

This paper presents an assessment of the use of insecticides in agricultural production Kursk region. Studied territorial load dominant insecticides in crop complex region for the period 2006-2010. Ranging of the region in terms of territorial load insecticides. Assessed indicators of relative environmental risk of formation of pathology of the gastrointestinal tract of the child population of the Kursk region in the intensive use of insecticides. Environmentally sensitive identified pathologies such as peptic ulcer and duodenal ulcer, gastritis and duodenitis, functional bowel disorders, gall bladder and bile ducts.

This article explores the methodological approaches to analyzing free radical processes in the body, particularly in relation to lipid peroxidation products (PLP). The levels of reactive oxygen species (ROS) and PLP were shown to vary depending on the time and conditions of biomaterial storage, which may affect the reliability of the results. It was revealed that the optimal storage conditions include freezing (t = ‒20 °C) for the determination of ROS and diene conjugates (DC) and deep cooling (t = ‒80 °C) for malondialdehyde (MDA). For the determination of Schiff bases, the temperature of biomaterial storage was found to be non-essential. The analysis period after receiving the biomaterial was defined as follows: up to 2 h for Schiff bases, up to 24 h for ROS, up to 36 h for MDA, and up to 48 h for DC. The obtained results can be useful for further scientific research and in clinical diagnostic laboratories that perform prooxidant-antioxidant balance tests.

PURPOSE. To consider the experience of using chemical water treatment waste in economic activity. To analyze scientific publications of Russian and foreign authors in order to determine the most popular industries in this waste and information about projects already implemented in Russia and abroad. To provide a brief analysis of the main areas of processing and disposal of sewage sludge in the world and in Russia. To assess the prospects for the use of chemical water treatment waste in the treatment of sewage sludge.METHODS. To achieve this goal, an assessment of the environmental impact of chemical water treatment waste on the environmental situation and human health was carried out on the example of Kazan CHP-1 (KTEC-1). A number of studies of KTEC-1 carbonate sludge have been carried out to determine the granulometric and elemental composition. results. The physico-chemical composition of carbonate sludge depends on a number of parameters of the water treatment system at an energy facility: the process of liming and coagulation of water, the amount of insoluble salts, the dewatering technology used, etc. Carbonate sludge is insoluble in water, has a typical chemical composition containing calcium carbonate (CaCO3), calcium oxide (CaO), magnesium carbonate (MgCO3), magnesium oxide (MgO), iron hydroxide (Fe(OH)3), silicon dioxide (SiO2), etc.CONCLUSION. The use of this type of technological process makes it possible to reduce the amount of calcium oxide used and replace it with calcium oxide from carbonate sludge. The use of carbonate sludge as a sediment stabilizer due to the CaO content is confirmed by laboratory studies. Due to these data, the disposal of chemical water treatment waste is ensured, less pollution of environmental objects is achieved.

THE PURPOSE. A complex of various physico-chemical methods has been studied to explore the possibilities of reuse of oil residues (oil sludge) of low-sulfur high-paraffin oil deposits of the Mangyshlak peninsula (Kazakhstan) as a promising raw material for boiler and marine fuel with improved operational and environmental characteristics.METHODS. Determination of the conditional viscosity of oil sludge (in degrees Engler, ° E) was carried out using an Engler viscometer VU-M-PCP according to GOST 6258-85 «Petroleum products. The method of determining the conditional viscosity». Studies of the lowest working heat of combustion of oil sludge were carried out using an adiabatic bomb calorimeter ABK-1B (Russia) according to GOST 21261-91 "Petroleum products. Method for determining the highest heat of combustion and calculation of the lowest heat of combustion". Determination of the mass fraction of sulfur in the studied oil sludge was also carried out using an adiabatic bomb calorimeter ABK-1B (Russia) according to GOST 3877-88 «Petroleum products. Method of determination of sulfur by burning in a calorimetric bomb». To analyze the results obtained, data obtained using the nuclear magnetic resonance method were used. Proton NMR spectra were recorded on a Bruker AVANCE III NMR spectrometer operating at a frequency of 600.13 MHz for 1H and equipped with a highresolution inverse sensor for three cores (TXI, 5 mm). Data processing and analysis were performed using Bruker Topspin 3.6.1.RESULTS. It is shown that in terms of heat of combustion and viscosity properties at temperatures above 50 oC, this oil sludge is similar to boiler fuel oil M100. It was found that the use of carbonate sludge of chemical water treatment at a concentration of 0.1 wt. % allows you to further reduce the viscosity by 5-6% and reduce the sulfur content in the combustion products, without reducing the lower working heat of combustion of the oil product. The complex nature of the relationship between the width of NMR lines and viscous properties has been revealed, which may indicate the existence of associates of highmolecular paraffins even in slightly viscous liquid petroleum products. The nature and characteristic sizes of the resulting associates are discussed. It is shown that the addition of medium-distillate diesel fractions will make it possible to obtain a better fuel option for marine engines, gas turbine and boiler installations with a reduced amount of resinous-asphaltene substances, reduced viscosity values and solidification temperatures, high heat of combustion and low sulfur content.СONCLUSION. The conducted complex of physico-chemical studies has shown the possibility of using low-sulfur Mangyshlak oil sludge as a basis for obtaining fuel for marine engines, gas turbine and boiler plants, steam boilers and industrial furnaces.

The article describes features of operation and monitoring of low-water bridges, which are found on highways of regional, intermunicipal and local importance. Vibrations of the bridge span are considered in detail, taking into account its interaction with other structural elements and the environment. As a characteristic, the change of which takes into account the change in the state of the bridge structure, it is proposed to use the frequency of natural vibrations. To simulate the dynamic effects of transport and the dynamic behavior of individual elements and the entire structure as a whole, it is proposed to use viscoelastic elements of the Kelvin–Voigt type. When solving the problem, an approach has been implemented that makes it possible to take into account the anisotropic properties of the superstructure associated with various reinforcement along and across the roadway of the bridge, and to present the design scheme of the span not in the form of a beam supported at the edges with the help of hinges or viscoelastic dampers, but in the form of a plate, which can have different fxing conditions along the entire contour. The use of the proposed model and approach will make it possible to obtain the necessary data on the state of low-water bridges, for which there is often no possibility of visual inspection or instrumental inspection from the lower side of the bearing part of the superstructure. By the values of the frequency of natural vibrations, it is possible to estimate the water level above the low-water period and predict food situations, during which the roadway of the low-water bridge may be fooded.

Engineering structures form an integral part of the railways, both already operated and yet designed. The joint work of the upper structure of the railway track and the supporting structures of the bridge crossing is an important condition for the normal operation of the railway section without various restrictions and additional work on the current maintenance and diagnostics of structural elements. Presented study is devoted to the investigation of the stress-strain state of a small railway bridge with a beam design, when the axis of the rail-sleeper grid relative to the axis of the bridge is shifted by an amount exceeding the limit value determined by regulatory documents. In the analytical calculation of the behavior parameters and the state of the span under the action of the load, a differential equation is used that describes the vertical vibrations of the beam and allows considering them as a combination of forced and free vibrations. In numerical modeling, the finite element method is used as the solution method, the deter mining equations of which contain linear and angular displacements of nodes of the calculation scheme as unknowns. As a result of the calculations, graphical dependences for normal and horizontal displacements, internal forces, principal and equivalent stresses at various points of the span are obtained. Presented values show an increase in bending and torsional forces, as well as principal stresses when the axis of the railway track is displaced relative to the axis of the bridge. It is noted that although the increase in stresses (by about 6 %) can generally be considered insignificant, the presence of defects in the span beams (concrete chips, cracks in the stretched zone, exposure and corrosion of working reinforcement, decrease in the calculated cross section, leaching of cement stone from concrete, decrease in concrete strength over time) can make it a significant enough factor limiting the operational capabilities of bridge crossings.

The effectiveness of complex drug “Bifidum BAG” for status correction of large intestine microbiocenosis and antioxidant properties of colonocytes in experimental dysbiosis has been studied. Acomplex drug was administered to experimental animals, which includes Bifidobacterium and Dihydroquercetin. Quantitative and qualitative study of large intestine was done in mices by bacteriological method. The state of lipid peroxidation system was evaluatedaccoding to the content of acylhydroperoxide and malonic dialdehyde. The state of antioxidant protective system was reached by means of catalase and superoxide dismutase activity. Experimental dysbiosis was shown as significant changes in mucosal microflora, changes colonocytes antioxidant properties. The use of the complex preparation “Bifidum BAG”, led to the normalization of the colon microbiota (11 of 16 microorganisms were recovered). After correction gentamicin-associated dysbiosis with a complex probiotic, a positive effect of the drug on the colonocytes antioxidant defense was noted. So the activity of catalase increased 1.1 times, compared with the determined index in the group “dysbiosis”. The activity of superoxide dismutase increased 2 times in comparison with the group “dysbiosis”, exceeding the value of the control group. The concentration of LPO products in colonocytes of experimental animals decreased significantly. The content of malonicdialdehyde and acylhydroperoxide decreased 1.6 times and 5.6 times in comparison with the determined index of the group “dysbiosis”, respectively.

A problem which is examined in the article before was not the article of scientific illumination. It served reason of appeal of author to the archived sources which are first entered in a scientific turn. Actuality of the article consists in that displays of panislamizm and pantyurkizm, having deep roots in the past, in one or another degree take place and now. Research is based on the documents of the Record Office of Republic Crimea, which were at one time geared-up Department of police and his Crimean structures. An author comes in to the conclusion, that in Crimea, as well as in other regions of the Russian empire, where a moslem population lived compact, panislamist and pantyurkist motion was got by development. This motion was headed the representatives of intelligentsia, well-off and influential persons. One of them was IsmaelGasprinskiy, leader of pantyurkist motion of all-russian scale. Panislamizm in Crimea was organizationally designed as organizations of «Conscience». This structure can be considered the first national political party of Crimean Tatars. Crimean pantyurkists and panislamists had regular connections with the centers of Russian, Turkish, Romanian moslem motions. The fact of organization of group of the Crimean national revolutionaries in the capital of Turkey deserves attention. It is the important certificate of the close interlacing revolutionary and panislamist activity.

Herein we present the results of studying the effects of different isotopes of magnesium, magnetic 25Mg and nonmagnetic 24Mg, upon the post-radiation recovery of yeast cells, S. cerevisiae, irradiated by short-wave UV light (240 - 260 nm) or ionizing radiation (300 Gy). The recovery process of the cells enriched with the magnetic 25Mg proceeds two times faster than the post-radiation recovery of the cells, enriched with the nonmagnetic 24Mg. After gamma-irradiation, the fraction of the irreversible damages in the cells enriched with 25Mg was 50 - 60 % less than in the cells enriched with 24Mg. Thus, the magnetic isotope effect has been detected, i.e. – the acceleration of post-radiation recovery of the cells by the magnetic isotope’s nuclear spin of magnesium (nuclear spin catalysis). Obtained results demonsrate the fundamental possibility of creating new radioprotectors and radiomitigators based on stable magnetic isotopes.

Abstract. When designing bridges on motorways and railways, conventional beam or trussed design schemes of structures made of steel or reinforced concrete are used, but at present there is a significant increase in the speeds of motion of individual vehicles, axial loads and total train weight increase, and temporary intervals between trains. These factors lead to a significant increase in dynamic effects and necessitate the use of non-classical design schemes for artificial structures of transport infrastructure. In this study, it is proposed to take a threespan arch bridge with suspended central span structure as the basis for unified bridge overpass. Such an arrangement will allow changing the design length of the central span in a fairly wide range, reducing the total number of supports with an increase in the total length of the bridge overpass, and using a similar design as a double-track railroad, two- or four-lane motorway bridge. Calculations carried out and the results obtained for calculating displacements, internal forces and stresses in the units and elements of the proposed bridge overpass design allow concluding about the allowable limit values of the values found, sufficiently uniform load of all its main elements, the absence of strongly marked large-scale stress concentrators. Proposed design allows setting different sizes of spans during the design, reducing the number or even avoiding the installation of channel supports, adapting this structure for the passage of both rail and road transport. Design of the bridge, mathematical model of which is described in detail in the article, can be manufactured at the factory, and then delivered to the installation site and mounted there, which significantly reduces the final construction cost and makes it a profitable solution, for example, for arranging railway interchanges at different levels.

The paper presents the novel approach of user identification based on behavior analytics of user operations with a text information. It is offered to describe user behavior by content of his text documents. The structured representation of the considered behavioral information is carried out based on representation of documents text content in the user topic space, which is created by non-negative matrix factorization. The topic weights in the document characterize the user’s topic trend during an operating time with this document. The time variation of the topic weight values creates multidimensional time series that describe the history of user behavior when working with text data. Forecasting of such time series will allow for user identification based on estimated deviation of observed topic trend from the predicted topic weight values. This paper also presents the new time series forecasting method based on orthogonal nonnegative matrix factorization (ONMF) which is used within proposed user identification approach. It is worth noting that nonnegative matrix factorization methods were not used before for the time series forecasting task. The proposed user identification approach has been experimentally verified on the example of real corporate email correspondence created from the Enron dataset. In addition, experiments with other today popular forecasting methods have shown the superiority of proposed forecasting method in quality of user’s topic weights classification. Also we investigated two different approaches to estimates of the deviation of a time series point from the predicted value: absolute deviation and p-value estimation. Experiments have shown that both discussed approaches of deviation estimates are applicable in the proposed user identification approach.

Aim. Study the changes in the composition of animals large intestine microbiocenosis and molecular-biochemical parameters of blood plasma and colonocytes in experimental gentamicin dysbiosis, possibility of correction using probiotic. Materials and methods. Drug dysbiosis was simulated by administration of gentamicin intraperitoneally and with correction aim injected probiotic. Quantitative and qualitative study of mucous microflora of the mice large intestine was performed by bacteriological method. The state of lipid peroxidation system was judged about by content of acylhydroperoxide and malonic dialdehyde, antioxidant protection system - by catalase and superoxide dismutase. Results. As a result of the study, a change in the composition of the intestinal microflora, a decrease in the enzymatic activity of antioxidant defense system in blood plasma and colonocytes, an increase in the content of lipid peroxidation products in blood plasma and colonocytes were recorded. The corrective effect of RioFlora Immuno Neo probiotic regarding the restoration of the intestine normobiocenosis and the molecular-biochemical parameters of animal colonocytes was noted. Conclusion. The use of the probiotic led to the restoration of microbial equilibrium in the intestinal microbiocenosis, and also had a positive effect on the superoxide dismutase activity of colonocytes, stabilization of the malonic dialdehyde content in the colon tissue.

Due to the development of high-speed operation, the problem of providing high-quality communication channels for train passengers, control and security systems, caused by the difficulty of fast positioning of the carriage, the large Doppler extension of the transmitted signal and the increasing amount of data transferred, is becoming especially topical at present. Two solutions can be conceptually possible in order to increase the coverage area near the railroad right-of-way: installation of a set of relatively small antennas of transmitting stations along the track or installation of powerful transmitters on high antenna-mast structures. Communication facilities exceeding 75 m are classified as particularly dangerous, technically complex communication facilities, and communication facilities exceeding 100 m, - as unique facilities. According to normative legal documents for structures classified as particularly dangerous, technically complex or as unique objects, it is necessary to additionally determine the aerodynamic coefficients by blowing structures in wind tunnels or by recommendations developed by specialized organizations. In view of the above, it is relevant to solve the problem of developing recommendations for the determination of aerodynamic coefficients and its approval as a guiding regulatory and technical document. This study is devoted to the development of a mathematical model for the behavior of an antenna-mast structure under wind influence, which would allow determining the aerodynamic coefficients when collecting loads on newly designed or currently ope rated structures, and also adequately predict the behavior and condition of the object at various stages of the life cycle.

Objective: to preliminarily assess the feasibility of elastography in endobronchial ultrasonography and to compare characteristics via different accesses.Material and methods. The investigation enrolled 3 patients (malignant, benign mediastinal adenopathy, paratracheal tumor). Elastography was carried out using a Pentax EB-1970UK echobronchoscope with a Hitachi Noblus ultrasound scanner. All the patients underwent fine-needle aspiration biopsy of mediastinal and pulmonary lymph nodes/masses with 22G needles (Cook, Medi-Globe). Sequential study of the same group of lymph nodes through different approaches through the esophagus and trachea was conducted, and its characteristics were compared in one patient.Results. A total of 8 lymph nodes and one paratracheal mass (Group 4L-7-4R-2R) were assessed in three patients. Reproducible images acceptable for visual assessment were obtained in all cases. The wall of the trachea and bronchi had no significant negative impact on the quality of an obtained image. Both malignant lesion of lymph nodes and paratracheal mass was accompanied by decreased tissue elasticity in the area of interest. Assessment of the same benign lymph node through different approaches revealed a clear discordance between elastographic findings with a drastic decrease in elasticity values via an endobronchial approach.Conclusion. Endobronchial ultrasonography elastography is technically feasible. The wall of the trachea and bronchi has no significant impact on the quality of an obtained image; elastographic data are reproducible during re-measurements. Comparison of elastographic characteristics through different approaches suggests that there is a tendency to overestimate data on lymph node density during endobronchial examination versus a transesophageal approach. Thus, the direct transfer of the accumulated data and patterns of elastographic diagnosis to an endobronchial approach is impossible and likely to require a revision of criteria to estimate malignancy-associated changes during its application.

Aim. Study the composition ofcolon microbiocenosis and antioxidant properties ofcolonocytes under the conditions of experimental dysbiosis and prophylaxis application of emoxipin. Materials and methods. With the aim of prophylaxis, antioxidant emoxipin was administered to mice, in which medicinal dysbiosis was formed by intraperitoneal administration of gentamicin. Quantitative and qualitative study of mucous microflora of the mice colon was carried out by a bacteriological method. The state of lipid peroxidation system was judged by the content of acylhydroperoxides and malonic dialdehyde, system of antioxidant protection - by enzyme activity (catalase and superoxide dismutase). Results. Experimental dysbiosis of the colon manifested by changes in the composition of mucous microflora of the animals and antioxidant properties of colonocytes. Dysbiosis prophylaxis by emoxipin resulted in normalization of the activity of antioxidant protection enzymes and products of lipid peroxidation in intestine tissue. Conclusion. The study results allow to consider, that use of emoxipin results in an increase of adaptive-compensatory capabilities of the macroorganism during experimental dysbiosis.

Aim. Study the effect of RioFlora Immuno Neo and Bifiform probiotics on the colon microflora composition under the conditions of experimental dysbiosis in mice. Materials and methods. Medicinal dysbiosis was modelled in animals by gentamicin administration, probiotics were administered intragastrally by the end of dysbiosis formation. Quantitative and qualitative study of mucous microflora of mice colon was carried out by a bacteriological method. Results. Correction of dysbiosis by probiotics has resulted in correction of the intestine microflora composition, and more pronounced when RioFlora Immuno Neo was used. Conclusion. The results of the study allow to recommend the use of these preparations for selective correction of colon dysbiosis.

The patients with Ischemic heart disease (IHD) who were ill since a few months till a few years have been checked-up. Fifty one patient suffering from IHD who were dispensary polyclinic treated have been medically examined. Among the examined patients there were 32 ill people with stenocardia tension of the 1st and 2 nd functional classes, 3 persons with unstable stenocardia, 11 patients with auricular fibrillation, 3 patients were with ventricular premature beats and tachycardia, atrioventricular blocks of the 3rd degree were also found in 2 patients. The majority of ill people were revealed as cardiac failure patients of 2A stage - 35 patients, as well as arterial hypertension of the 3rd stage in 44 people.Body mass index (BMI) was more than 30 kg/m2. An average age of ill people was 65 years. The condition of carbohydrate exchange in the people who were ill was controlled by way of determining the HbAlc by immunochemical method and the level of an empty stomach glucose plasm - by glucose oxidase way. It has been found out that an average level of blood glucose came up to 6,24±0,27 mmol/l. In this case an average value of glycated haemoglobin was registered as 5,95± 0,21%. An average value as for body weight Index was 30,07±4,15 kg/m2.The majority of the people madically checked had the level of low thickness lipoproteins higher than 2,6 mmol/l (100 mg/dl). Seventeen medically checked people manifested the level of high thickness lipoproteins that was more than 1.3 mmol/l (50 mg/dl). Sixteen patients had triglyceride level more than 1.7 mmol/l (150 mg/dl). Eight people out of fifteen checked up manifested an increased level of C-reactive albumen.The level of blood glucose and glycated haemoglobin was correlated with the level of aspartate transaminose. Alterations in the content of common cholesterol of blood serum for the value of 52,9%, triglycerides- for the value of 17,2% depended upon the alterations in the content of glycated haemoglobin. The conclusion has been made that Ichemic heart disease patients reveal dominating metabolic disturbances, reflect disglycemia, dislipidemia as well as obesity and all that radically aggrivates the major diseases processes.

The given paper attempts to objectify the course of a tumor process in patients diagnosed as having throat cancer during radiation or chemoradiation therapy. The authors propose a diagnostic algorithm which enables one not only to see the actual extent of a tumor, but also to estimate the degree of its resorption; hence, to more accurately plan special treatment and to timely change the treatment policy.