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9 results on '"Völkel, Cosima"'

1. Cytokeratin 7 and cytokeratin 20 expression in cancer: A tissue microarray study on 15,424 cancers

Author

Dum, David, Menz, Anne, Völkel, Cosima, De Wispelaere, Noémi, Hinsch, Andrea, Gorbokon, Natalia, Lennartz, Maximilian, Luebke, Andreas M., Hube-Magg, Claudia, Kluth, Martina, Fraune, Christoph, Möller, Katharina, Bernreuther, Christian, Lebok, Patrick, Clauditz, Till S., Jacobsen, Frank, Sauter, Guido, Uhlig, Ria, Wilczak, Waldemar, Steurer, Stefan, Minner, Sarah, Marx, Andreas H., Simon, Ronald, Burandt, Eike, and Krech, Till

Published
2022
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2. Cytokeratin 5 and cytokeratin 6 expressions are unconnected in normal and cancerous tissues and have separate diagnostic implications

Author

Völkel, Cosima, De Wispelaere, Noémi, Weidemann, Sören, Gorbokon, Natalia, Lennartz, Maximilian, Luebke, Andreas M., Hube-Magg, Claudia, Kluth, Martina, Fraune, Christoph, Möller, Katharina, Bernreuther, Christian, Lebok, Patrick, Clauditz, Till S., Jacobsen, Frank, Sauter, Guido, Uhlig, Ria, Wilczak, Waldemar, Steurer, Stefan, Minner, Sarah, Krech, Rainer H., Dum, David, Krech, Till, Marx, Andreas H., Simon, Ronald, Burandt, Eike, and Menz, Anne

Published
2022
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3. Mammaglobin-A Expression Is Highly Specific for Tumors Derived from the Breast, the Female Genital Tract, and the Salivary Gland

Author

Gorbokon, Natalia, primary, Timm, Patrick, additional, Dum, David, additional, Menz, Anne, additional, Büscheck, Franziska, additional, Völkel, Cosima, additional, Hinsch, Andrea, additional, Lennartz, Maximilian, additional, Luebke, Andreas M, additional, Hube-Magg, Claudia, additional, Fraune, Christoph, additional, Krech, Till, additional, Lebok, Patrick, additional, Clauditz, Till S, additional, Jacobsen, Frank, additional, Sauter, Guido, additional, Uhlig, Ria, additional, Steurer, Stefan, additional, Minner, Sarah, additional, Marx, Andreas H., additional, Simon, Ronald, additional, Burandt, Eike, additional, Bernreuther, Christian, additional, and Höflmayer, Doris, additional

Published
2023
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4. Pan-keratin Immunostaining in Human Tumors: A Tissue Microarray Study of 15,940 Tumors.

Author

Menz, Anne, Gorbokon, Natalia, Viehweger, Florian, Lennartz, Maximilian, Hube-Magg, Claudia, Hornsteiner, Lisa, Kluth, Martina, Völkel, Cosima, Luebke, Andreas M., Fraune, Christoph, Uhlig, Ria, Minner, Sarah, Dum, David, Höflmayer, Doris, Sauter, Guido, Simon, Ronald, Burandt, Eike, Clauditz, Till S., Lebok, Patrick, and Jacobsen, Frank

Subjects
BREAST, TRANSITIONAL cell carcinoma, RENAL cell carcinoma, IMMUNOSTAINING, EPITHELIAL tumors, NEUROENDOCRINE tumors
Abstract

To evaluate the efficiency of pan-keratin immunostaining, tissue microarrays of 13,501 tumor samples from 121 different tumor types and subtypes as well as 608 samples of 76 different normal tissue types were analyzed by immunohistochemistry. In normal tissues, strong pan-keratin immunostaining was seen in epithelial cells. Staining intensity was lower in hepatocytes, islets of Langerhans, and pneumocytes but markedly reduced in the adrenal cortex. Pan-keratin was positive in ≥98% of samples in 62 (83%) of 75 epithelial tumor entities, including almost all adenocarcinomas, squamous cell and urothelial carcinomas. Only 17 of 121 tumor entities (13%) had a pan-keratin positivity rate between 25% and 98%, including tumors with mixed differentiation, endocrine/neuroendocrine tumors, renal cell carcinomas, adrenocortical tumors, and particularly poorly differentiated carcinoma subtypes. The 15 entities with pan-keratin positivity in 0.9%-25% were mostly of mesenchymal origin. Reduced/absent pan-keratin immunostaining was associated with high UICC stage (p = 0.0001), high Thoenes grade (p = 0.0183), high Fuhrman grade (p = 0.0049), advanced tumor stage (p < 0.0001) and lymph node metastasis (p = 0.0114) in clear cell renal cell carcinoma, advanced pT stage (p = 0.0007) in papillary renal cell carcinoma, and with advanced stage (p = 0.0023), high grade (p = 0.0005) as well as loss of ER and PR expression (each p < 0.0001) in invasive breast carcinoma of no special type (NST). In summary, pan-keratin can consistently be detected in the vast majority of epithelial tumors, although pan-keratin can be negative a fraction of renal cell, adrenocortical and neuroendocrine neoplasms. The data also link reduced pan-keratin immunostaining to unfavorable tumor phenotype in in epithelial neoplasms. [ABSTRACT FROM AUTHOR]

Published
2023
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5. Pan-keratin Immunostaining in Human Tumors: A Tissue Microarray Study of 15,940 Tumors

Author

Menz, Anne, primary, Gorbokon, Natalia, additional, Viehweger, Florian, additional, Lennartz, Maximilian, additional, Hube-Magg, Claudia, additional, Hornsteiner, Lisa, additional, Kluth, Martina, additional, Völkel, Cosima, additional, Luebke, Andreas M., additional, Fraune, Christoph, additional, Uhlig, Ria, additional, Minner, Sarah, additional, Dum, David, additional, Höflmayer, Doris, additional, Sauter, Guido, additional, Simon, Ronald, additional, Burandt, Eike, additional, Clauditz, Till S., additional, Lebok, Patrick, additional, Jacobsen, Frank, additional, Steurer, Stefan, additional, Krech, Till, additional, Marx, Andreas H., additional, and Bernreuther, Christian, additional

Published
2022
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6. sj-docx-2-ijs-10.1177_10668969221117243 - Supplemental material for Pan-keratin Immunostaining in Human Tumors: A Tissue Microarray Study of 15,940 Tumors

Author

Menz, Anne, Gorbokon, Natalia, Viehweger, Florian, Lennartz, Maximilian, Hube-Magg, Claudia, Hornsteiner, Lisa, Kluth, Martina, Völkel, Cosima, Luebke, Andreas M., Fraune, Christoph, Uhlig, Ria, Minner, Sarah, Dum, David, Höflmayer, Doris, Sauter, Guido, Simon, Ronald, Burandt, Eike, Clauditz, Till S., Lebok, Patrick, Jacobsen, Frank, Steurer, Stefan, Krech, Till, Marx, Andreas H., and Bernreuther, Christian

Subjects
FOS: Clinical medicine, 110323 Surgery, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
Abstract

Supplemental material, sj-docx-2-ijs-10.1177_10668969221117243 for Pan-keratin Immunostaining in Human Tumors: A Tissue Microarray Study of 15,940 Tumors by Anne Menz, Natalia Gorbokon, Florian Viehweger, Maximilian Lennartz, Claudia Hube-Magg, Lisa Hornsteiner, Martina Kluth, Cosima Völkel, Andreas M. Luebke, Christoph Fraune, Ria Uhlig, Sarah Minner, David Dum, Doris Höflmayer, Guido Sauter, Ronald Simon, Eike Burandt, Till S. Clauditz, Patrick Lebok, Frank Jacobsen, Stefan Steurer, Till Krech, Andreas H. Marx and Christian Bernreuther in International Journal of Surgical Pathology

Published
2022
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7. sj-pdf-1-ijs-10.1177_10668969221117243 - Supplemental material for Pan-keratin Immunostaining in Human Tumors: A Tissue Microarray Study of 15,940 Tumors

Author

Menz, Anne, Gorbokon, Natalia, Viehweger, Florian, Lennartz, Maximilian, Hube-Magg, Claudia, Hornsteiner, Lisa, Kluth, Martina, Völkel, Cosima, Luebke, Andreas M., Fraune, Christoph, Uhlig, Ria, Minner, Sarah, Dum, David, Höflmayer, Doris, Sauter, Guido, Simon, Ronald, Burandt, Eike, Clauditz, Till S., Lebok, Patrick, Jacobsen, Frank, Steurer, Stefan, Krech, Till, Marx, Andreas H., and Bernreuther, Christian

Subjects
FOS: Clinical medicine, 110323 Surgery, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
Abstract

Supplemental material, sj-pdf-1-ijs-10.1177_10668969221117243 for Pan-keratin Immunostaining in Human Tumors: A Tissue Microarray Study of 15,940 Tumors by Anne Menz, Natalia Gorbokon, Florian Viehweger, Maximilian Lennartz, Claudia Hube-Magg, Lisa Hornsteiner, Martina Kluth, Cosima Völkel, Andreas M. Luebke, Christoph Fraune, Ria Uhlig, Sarah Minner, David Dum, Doris Höflmayer, Guido Sauter, Ronald Simon, Eike Burandt, Till S. Clauditz, Patrick Lebok, Frank Jacobsen, Stefan Steurer, Till Krech, Andreas H. Marx and Christian Bernreuther in International Journal of Surgical Pathology

Published
2022
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8. Trophoblast Cell Surface Antigen 2 Expression in Human Tumors: A Tissue Microarray Study on 18,563 Tumors

Author

Dum, David, primary, Taherpour, Noushin, additional, Menz, Anne, additional, Höflmayer, Doris, additional, Völkel, Cosima, additional, Hinsch, Andrea, additional, Gorbokon, Natalia, additional, Lennartz, Maximilian, additional, Hube-Magg, Claudia, additional, Fraune, Christoph, additional, Bernreuther, Christian, additional, Lebok, Patrick, additional, Clauditz, Till S., additional, Jacobsen, Frank, additional, Sauter, Guido, additional, Uhlig, Ria, additional, Wilczak, Waldemar, additional, Steurer, Stefan, additional, Minner, Sarah, additional, Marx, Andreas H., additional, Simon, Ronald, additional, Burandt, Eike, additional, Krech, Till, additional, and Luebke, Andreas M., additional

Published
2022
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9. Cytokeratin 5 and cytokeratin 6 expressions are unconnected in normal and cancerous tissues and have separate diagnostic implications

Author

Völkel, Cosima, primary, De Wispelaere, Noémi, additional, Weidemann, Sören, additional, Gorbokon, Natalia, additional, Lennartz, Maximilian, additional, Luebke, Andreas M., additional, Hube-Magg, Claudia, additional, Kluth, Martina, additional, Fraune, Christoph, additional, Möller, Katharina, additional, Bernreuther, Christian, additional, Lebok, Patrick, additional, Clauditz, Till S., additional, Jacobsen, Frank, additional, Sauter, Guido, additional, Uhlig, Ria, additional, Wilczak, Waldemar, additional, Steurer, Stefan, additional, Minner, Sarah, additional, Krech, Rainer H., additional, Dum, David, additional, Krech, Till, additional, Marx, Andreas H., additional, Simon, Ronald, additional, Burandt, Eike, additional, and Menz, Anne, additional

Published
2021
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