Search

Your search keyword '"Vítek, Libor"' showing total 547 results
Start Over Author "Vítek, Libor"
547 results on '"Vítek, Libor"'

5. Potential of therapeutic bile acids in the treatment of neonatal Hyperbilirubinemia.

Author

van der Schoor, Lori WE, Verkade, Henkjan J, Bertolini, Anna, de Wit, Sanne, Mennillo, Elvira, Rettenmeier, Eva, Weber, André A, Havinga, Rick, Valášková, Petra, Jašprová, Jana, Struik, Dicky, Bloks, Vincent W, Chen, Shujuan, Schreuder, Andrea B, Vítek, Libor, Tukey, Robert H, and Jonker, Johan W

Abstract

Neonatal hyperbilirubinemia or jaundice is associated with kernicterus, resulting in permanent neurological damage or even death. Conventional phototherapy does not prevent hyperbilirubinemia or eliminate the need for exchange transfusion. Here we investigated the potential of therapeutic bile acids ursodeoxycholic acid (UDCA) and obeticholic acid (OCA, 6-α-ethyl-CDCA), a farnesoid-X-receptor (FXR) agonist, as preventive treatment options for neonatal hyperbilirubinemia using the hUGT1*1 humanized mice and Ugt1a-deficient Gunn rats. Treatment of hUGT1*1 mice with UDCA or OCA at postnatal days 10-14 effectively decreased bilirubin in plasma (by 82% and 62%) and brain (by 72% and 69%), respectively. Mechanistically, our findings indicate that these effects are mediated through induction of protein levels of hUGT1A1 in the intestine, but not in liver. We further demonstrate that in Ugt1a-deficient Gunn rats, UDCA but not OCA significantly decreases plasma bilirubin, indicating that at least some of the hypobilirubinemic effects of UDCA are independent of UGT1A1. Finally, using the synthetic, non-bile acid, FXR-agonist GW4064, we show that some of these effects are mediated through direct or indirect activation of FXR. Together, our study shows that therapeutic bile acids UDCA and OCA effectively reduce both plasma and brain bilirubin, highlighting their potential in the treatment of neonatal hyperbilirubinemia.

Published
2021

12. WED-280 Spectroscopy of blood plasma has the potential to differentiate metabolic dysfunction-associated steatohepatitis from steatosis

Author

Nováková, Barbora, primary, Vrtělka, Ondřej, additional, Králova, Kateřina, additional, Žižalová, Kateřina, additional, Šmíd, Václav, additional, Dvořák, Karel, additional, Petrtýl, Jaromír, additional, Vítek, Libor, additional, Leníček, Martin, additional, Setnička, Vladimír, additional, and Bruha, Radan, additional

Published
2024
Full Text
View/download PDF

22. The Ameliorating Effects of n-3 Polyunsaturated Fatty Acids on Liver Steatosis Induced by a High-Fat Methionine Choline-Deficient Diet in Mice

Author

Šmíd, Václav, primary, Dvořák, Karel, additional, Stehnová, Kamila, additional, Strnad, Hynek, additional, Rubert, Josep, additional, Stříteský, Jan, additional, Staňková, Barbora, additional, Stránská, Milena, additional, Hajšlová, Jana, additional, Brůha, Radan, additional, and Vítek, Libor, additional

Published
2023
Full Text
View/download PDF

49. Cyanine-flavonol hybrids as NIR-light activatable carbon monoxide donors in methanol and aqueous solutions

Author

Yang, Qiuyun, Muchová, Lucie, Štacková, Lenka, Stacko, Peter, Šindelář, Vladimir, Vítek, Libor, Klán, Petr, University of Zurich, and Klán, Petr

Subjects
10120 Department of Chemistry, Flavonols, 1503 Catalysis, 2506 Metals and Alloys, 2503 Ceramics and Composites, 1600 General Chemistry, Catalysis, Coatings and Films, 540 Chemistry, Electronic, Materials Chemistry, Optical and Magnetic Materials, Coloring Agents, 2505 Materials Chemistry, Carbon Monoxide, Methanol, 2508 Surfaces, Coatings and Films, Metals and Alloys, 2504 Electronic, Optical and Magnetic Materials, Water, General Chemistry, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Surfaces, Ceramics and Composites, Quinolines
Abstract

Here we report on carbon monoxide-photoreleasable compounds (photoCORMs) that combine heptamethine cyanine and flavonol chromophores and are activated upon irradiation with near-infrared light. Excellent CO-release yields and uncaging cross sections in aqueous solutions, enhanced water solubilities thanks to polar substituents or a host-guest approach using cucurbit[7]uril are demonstrated. The hybrids display outstanding biocompatibility and diverse, structure-dependent cell penetrability and internalization.

Published
2022

Catalog

Books, media, physical & digital resources
See catalog results