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Cet article est un compte-rendu du livre : Jean‑François Perrin, Poétique romanesque de la mémoire avant Proust, t. I. Éros réminiscent (xviie‑xviiie siècles), Paris : Classiques Garnier, coll. « Bibliothèque proustienne », 2017, 333 p., EAN 9782406063230 & Jean‑François Perrin, Poétique romanesque de la mémoire, t. II. De Senancour à Proust (xixe siècle), Paris : Classiques Garnier, coll. « Bibliothèque proustienne », 2018, 803 p., EAN 9782406079033.

International audience; Mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) is a heterogeneous syndrome. Surgery results in seizure freedom for most pharmacoresistant patients, but the epileptic and cognitive prognosis remains variable. The 2013 International League Against Epilepsy (ILAE) histopathological classification of hippocampal sclerosis (HS) has fostered research to understand MTLE-HS heterogeneity. We investigated the associations between histopathological features (ILAE types, hypertrophic CA4 neurons, granule cell layer alterations, CD34 immunopositive cells) and clinical features (presurgical history, postsurgical outcome) in a monocentric series of 247 MTLE-HS patients treated by surgery. NeuN, GFAP and CD34 immunostainings and a double independent pathological examination were performed. 186 samples were type 1, 47 type 2, 7 type 3 and 7 samples were gliosis only but no neuronal loss (noHS). In the type 1, hypertrophic CA4 neurons were associated with a worse postsurgical outcome and granule cell layer duplication was associated with generalized seizures and episodes of status epilepticus. In the type 2, granule cell layer duplication was associated with generalized seizures. CD34+ stellate cells were more frequent in the type 2, type 3 and in noHS. These cells had a Nestin and SOX2 positive, immature neural immunophenotype. Patients with nodules of CD34+ cells had more frequent dysmnesic auras. CD34+ stellate cells in scarce pattern were associated with higher ratio of normal MRI and of stereo-electroencephalographic studies. CD34+ cells were associated with a trend for a better postsurgical outcome. Among CD34+ cases, we proposed a new entity of BRAF V600E positive HS and we described three hippocampal multinodular and vacuolating neuronal tumours. To conclude, our data identified new clinicopathological associations with ILAE types. They showed the prognostic value of CA4 hypertrophic neurons. They highlighted CD34+ stellate cells and BRAF V600E as biomarkers to further decipher MTLE-HS heterogeneity. This article is protected by copyright. All rights reserved.

Cet article est un compte-rendu du livre : Judith Schlanger, Le neuf, le différent et le déjà-là : une exploration de l’influence, Paris : Hermann, 2014, 250 p., EAN 9782705689438.

Si la première moitié du XXe siècle pense l’aventure romanesque comme une prolifération des possibles, la seconde verrait apparaître les limites de cette conception héritée de Jacques Rivière. En prenant comme cas de figure Un balcon en forêt (1958), le dernier roman de Julien Gracq, cette étude suggère que l’expérience de la « drôle de guerre » aura engendré, au coeur de la carrière littéraire de l’écrivain, une crise toute paradoxale, issue du désir de maintenir les possibles ouverts pour son personnage dans un monde devenu inhabitable., In Viewed as a proliferation of possibilities during the first half of the 20th century, romantic adventure departs from this definition derived from Jacques Rivière and narrows in scope over the next 50 years. Using as an illustration Julien Gracq’s last novel, A Balcony in the Forest (1958), this article suggests that Phoney War may have caused a paradoxical storm in the author’s literary career, one pitting his desire to safeguard the possibilities afforded his character against a now inhospitable world.

Cet article est un compte-rendu du livre : Amnésies françaises à l’époque gaullienne (1958‑1981). Littérature, cinéma, presse, politique, sous la direction de Nelly Wolf, Paris : Classiques Garnier, coll. « Rencontres », 2011, 291 p., EAN 9782812403415.