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1. Rubella virus-associated cutaneous granulomatous disease in an immunocompetent woman.

Author: Tl VL, Am CV, I GJ, Mj GG, Cm DM, A GL, G MG, S RR, P ML, and A MM
Subjects: Humans, Female, Rubella diagnosis, Rubella virology, Adult, Skin pathology, Skin virology, Rubella virus isolation & purification, Rubella virus genetics, Rubella virus immunology, Granuloma virology, Granuloma pathology
Published: 2024
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2. Soluble ACE2 correlates with severe COVID-19 and can impair antibody responses.

Author: Lebedin M, Ratswohl C, Garg A, Schips M, García CV, Spatt L, Thibeault C, Obermayer B, Weiner J, Velásquez IM, Gerhard C, Stubbemann P, Hanitsch LG, Pischon T, Witzenrath M, Sander LE, Kurth F, Meyer-Hermann M, and de la Rosa K
Abstract: Identifying immune modulators that impact neutralizing antibody responses against severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) is of great relevance. We postulated that high serum concentrations of soluble angiotensin-converting enzyme 2 (sACE2) might mask the spike and interfere with antibody maturation toward the SARS-CoV-2-receptor-binding motif (RBM). We tested 717 longitudinal samples from 295 COVID-19 patients and showed a 2- to 10-fold increase of enzymatically active sACE2 (a-sACE2), with up to 1 μg/mL total sACE2 in moderate and severe patients. Fifty percent of COVID-19 sera inhibited ACE2 activity, in contrast to 1.3% of healthy donors and 4% of non-COVID-19 pneumonia patients. A mild inverse correlation of a-sACE2 with RBM-directed serum antibodies was observed. In silico , we show that sACE2 concentrations measured in COVID-19 sera can disrupt germinal center formation and inhibit timely production of high-affinity antibodies. We suggest that sACE2 is a biomarker for COVID-19 and that soluble receptors may contribute to immune suppression informing vaccine design., Competing Interests: The Max Delbrück Center for Molecular Medicine in the Helmholtz Association and the Charité - Universitätsmedizin Berlin have filed three patent applications in connection with this work on which M.L., F.K., L.E.S., and K.D.L.R. (EP21155584.2); C.V.G. and K.D.L.R. (EP22164013.9); and M.L., C.R., C.V.G., and K.D.L.R. (EP21194414.5) are inventors., (© 2024 The Authors.)
Published: 2024
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3. Facile generation of surface diversity in gold nanoparticles.

Author: Paz MM, Veiga AP, Regueira T, Vázquez CV, and Arturo López Quintela M
Abstract: Surface chemistry is a key determinant of the physico-chemical and biological properties of gold nanoparticles (AuNPs). The introduction of chemical diversity in the surface of AuNPs is usually accomplished by place-exchange reactions using incoming ligands containing the desired terminal functional groups. As an alternative approach, we present here a simple, practical methodology to modify the surface of gold nanoparticles that allows the preparation of AuNPs stabilized with polyethyleneglycol (PEG) ligands with different surface chemistries using AuNPs stabilized with thiol-PEG-amino ligands as starting material. The surface modification reaction involves the acylation of the terminal amino groups in the ligand with an organic acid anhydride in an aqueous buffer. In addition to a full surface modification, this method also allows the synthesis of AuNPs with tailored mixed surfaces, containing two or more different functional groups, each of them at the desired extent. The ease of the experimental conditions for the reaction, purification, and for determining the level of surface modification makes this strategy an attractive alternative to current methods for the preparation of AuNPs with diverse surface chemistry., Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Carlos Vázquez Vázquez reports financial support was provided by Ministry of Science Technology and Innovations. Arturo López Quintela reports financial support was provided by Government of Galicia Department of Culture Education and Universities. Manuel M. Paz reports financial support was provided by Government of Galicia Department of Culture Education and Universities., (Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.)
Published: 2023
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4. Discriminating promiscuous from target-specific autoantibodies in COVID-19.

Author: Lebedin M, García CV, Spatt L, Ratswohl C, Thibeault C, Ostendorf L, Alexander T, Paul F, Sander LE, Kurth F, and de la Rosa K
Subjects: Humans, SARS-CoV-2, Autoantibodies, Peptidyl-Dipeptidase A, Immunoglobulin G, COVID-19
Abstract: Diverse autoantibodies were suggested to contribute to severe outcomes of COVID-19, but their functional implications are largely unclear. ACE2, the SARS-CoV-2 receptor and a key regulator of blood pressure, was described to be one of many targets of autoantibodies in COVID-19. ACE2 in its soluble form (sACE2) is highly elevated in the blood of critically ill patients, raising the question of whether sACE2:spike complexes induce ACE2 reactivity. Screening 247 COVID-19 patients, we observed elevated sACE2 and anti-ACE2 IgG that were poorly correlated. Interestingly, levels of IgGs recognizing ACE2, IFNα2, and CD26 strongly correlated in severe COVID-19, with 15% of sera showing polyreactivity versus 4.1% exhibiting target-directed autoimmunity. Promiscuous autoantibodies failed to impair the activity of ACE2 and IFNα2, while only specific anti-IFNα2 IgG compromised cytokine function. Our study suggests that the detection of autoantibodies in COVID-19 is often attributed to a promiscuous reactivity, potentially misinterpreted as target-specific autoimmunity with functional impact., (© 2023 The Authors. European Journal of Immunology published by Wiley-VCH GmbH.)
Published: 2023
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5. Effect of the high-level trigger for detecting long-lived particles at LHCb.

Author: Calefice L, Hennequin A, Henry L, Jashal B, Mendoza D, Oyanguren A, Sanderswood I, Sierra CV, and Zhuo J
Abstract: Long-lived particles (LLPs) show up in many extensions of the Standard Model, but they are challenging to search for with current detectors, due to their very displaced vertices. This study evaluated the ability of the trigger algorithms used in the Large Hadron Collider beauty (LHCb) experiment to detect long-lived particles and attempted to adapt them to enhance the sensitivity of this experiment to undiscovered long-lived particles. A model with a Higgs portal to a dark sector is tested, and the sensitivity reach is discussed. In the LHCb tracking system, the farthest tracking station from the collision point is the scintillating fiber tracker, the SciFi detector. One of the challenges in the track reconstruction is to deal with the large amount of and combinatorics of hits in the LHCb detector. A dedicated algorithm has been developed to cope with the large data output. When fully implemented, this algorithm would greatly increase the available statistics for any long-lived particle search in the forward region and would additionally improve the sensitivity of analyses dealing with Standard Model particles of large lifetime, such as K S 0 or Λ 0 hadrons., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Calefice, Hennequin, Henry, Jashal, Mendoza, Oyanguren, Sanderswood, Sierra, Zhuo and part of LHCb-RTA Collaboration.)
Published: 2022
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6. Observation of the Decay Λ_{b}^{0}→Λ_{c}^{+}τ^{-}ν[over ¯]_{τ}.

Author: Aaij R, Abdelmotteleb ASW, Beteta CA, Abudinén F, Ackernley T, Adeva B, Adinolfi M, Afsharnia H, Agapopoulou C, Aidala CA, Aiola S, Ajaltouni Z, Akar S, Albrecht J, Alessio F, Alexander M, Albero AA, Aliouche Z, Alkhazov G, Cartelle PA, Amato S, Amey JL, Amhis Y, An L, Anderlini L, Andersson M, Andreianov A, Andreotti M, Archilli F, Artamonov A, Artuso M, Arzymatov K, Aslanides E, Atzeni M, Audurier B, Bachmann S, Bachmayer M, Back JJ, Rodriguez PB, Balagura V, Baldini W, Baptista de Souza Leite J, Barbetti M, Barlow RJ, Barsuk S, Barter W, Bartolini M, Baryshnikov F, Basels JM, Bashir S, Bassi G, Batsukh B, Battig A, Bay A, Beck A, Becker M, Bedeschi F, Bediaga I, Beiter A, Belavin V, Belin S, Bellee V, Belous K, Belov I, Belyaev I, Bencivenni G, Ben-Haim E, Berezhnoy A, Bernet R, Berninghoff D, Bernstein HC, Bertella C, Bertolin A, Betancourt C, Betti F, Bezshyiko I, Bhasin S, Bhom J, Bian L, Bieker MS, Biesuz NV, Bifani S, Billoir P, Biolchini A, Birch M, Bishop FCR, Bitadze A, Bizzeti A, Bjørn M, Blago MP, Blake T, Blanc F, Blusk S, Bobulska D, Boelhauve JA, Garcia OB, Boettcher T, Boldyrev A, Bondar A, Bondar N, Borghi S, Borisyak M, Borsato M, Borsuk JT, Bouchiba SA, Bowcock TJV, Boyer A, Bozzi C, Bradley MJ, Braun S, Rodriguez AB, Brodzicka J, Gonzalo AB, Brundu D, Buonaura A, Buonincontri L, Burke AT, Burr C, Bursche A, Butkevich A, Butter JS, Buytaert J, Byczynski W, Cadeddu S, Cai H, Calabrese R, Calefice L, Cali S, Calladine R, Calvi M, Gomez MC, Magalhaes PC, Campana P, Quezada AFC, Capelli S, Capriotti L, Carbone A, Carboni G, Cardinale R, Cardini A, Carli I, Carniti P, Carus L, Akiba KC, Vidal AC, Caspary R, Casse G, Cattaneo M, Cavallero G, Celani S, Cerasoli J, Cervenkov D, Chadwick AJ, Chapman MG, Charles M, Charpentier P, Barajas CAC, Chefdeville M, Chen C, Chen S, Chernov A, Chobanova V, Cholak S, Chrzaszcz M, Chubykin A, Chulikov V, Ciambrone P, Cicala MF, Vidal XC, Ciezarek G, Clarke PEL, Clemencic M, Cliff HV, Closier J, Cobbledick JL, Coco V, Coelho JAB, Cogan J, Cogneras E, Cojocariu L, Collins P, Colombo T, Congedo L, Contu A, Cooke N, Coombs G, Corredoira I, Corti G, Sobral CMC, Couturier B, Craik DC, Crkovská J, Torres MC, Currie R, Da Silva CL, Dadabaev S, Dai L, Dall'Occo E, Dalseno J, D'Ambrosio C, Danilina A, d'Argent P, Dashkina A, Davies JE, Davis A, Francisco OA, De Bruyn K, De Capua S, De Cian M, Da Graca UFC, De Lucia E, De Miranda JM, De Paula L, De Serio M, De Simone D, De Simone P, De Vellis F, de Vries JA, Dean CT, Debernardis F, Decamp D, Dedu V, Del Buono L, Delaney B, Dembinski HP, Denysenko V, Derkach D, Deschamps O, Dettori F, Dey B, Di Cicco A, Di Nezza P, Didenko S, Maronas LD, Dijkstra H, Dobishuk V, Dong C, Donohoe AM, Dordei F, Dos Reis AC, Douglas L, Dovbnya A, Downes AG, Dudek MW, Dufour L, Duk V, Durante P, Durham JM, Dutta D, Dziurda A, Dzyuba A, Easo S, Egede U, Egorychev V, Eidelman S, Eisenhardt S, Ek-In S, Eklund L, Ely S, Ene A, Epple E, Escher S, Eschle J, Esen S, Evans T, Falcao LN, Fan Y, Fang B, Farry S, Fazzini D, Féo M, Prieto AF, Fernez AD, Ferrari F, Lopes LF, Rodrigues FF, Sole SF, Ferrillo M, Ferro-Luzzi M, Filippov S, Fini RA, Fiorini M, Firlej M, Fischer KM, Fitzgerald DS, Fitzpatrick C, Fiutowski T, Fkiaras A, Fleuret F, Fontana M, Fontanelli F, Forty R, Foulds-Holt D, Lima VF, Sevilla MF, Frank M, Franzoso E, Frau G, Frei C, Friday DA, Fu J, Fuehring Q, Gabriel E, Galati G, Torreira AG, Galli D, Gambetta S, Gan Y, Gandelman M, Gandini P, Gao Y, Garau M, Martin LMG, Moreno PG, García Pardiñas J, Plana BG, Rosales FAG, Garrido L, Gaspar C, Geertsema RE, Gerick D, Gerken LL, Gersabeck E, Gersabeck M, Gershon T, Gerstel D, Giambastiani L, Gibson V, Giemza HK, Gilman AL, Giovannetti M, Gioventù A, Gironell PG, Giugliano C, Gizdov K, Gkougkousis EL, Gligorov VV, Göbel C, Golobardes E, Golubkov D, Golutvin A, Gomes A, Fernandez SG, Abrantes FG, Goncerz M, Gong G, Gorbounov P, Gorelov IV, Gotti C, Grabowski JP, Grammatico T, Cardoso LAG, Graugés E, Graverini E, Graziani G, Grecu A, Greeven LM, Grieser NA, Grillo L, Gromov S, Cazon BRG, Gu C, Guarise M, Guittiere M, Günther PA, Gushchin E, Guth A, Guz Y, Gys T, Hadavizadeh T, Haefeli G, Haen C, Haimberger J, Haines SC, Halewood-Leagas T, Hamilton PM, Hammerich JP, Han Q, Han X, Hansen EB, Hansmann-Menzemer S, Harnew N, Harrison T, Hasse C, Hatch M, He J, Hecker M, Heijhoff K, Heinicke K, Henderson RDL, Hennequin AM, Hennessy K, Henry L, Heuel J, Hicheur A, Hill D, Hilton M, Hollitt SE, Hou R, Hou Y, Hu J, Hu J, Hu W, Hu X, Huang W, Huang X, Hulsbergen W, Hunter RJ, Hushchyn M, Hutchcroft D, Hynds D, Ibis P, Idzik M, Ilin D, Ilten P, Inglessi A, Ishteev A, Ivshin K, Jacobsson R, Jage H, Jakobsen S, Jans E, Jashal BK, Jawahery A, Jevtic V, Jiang X, John M, Johnson D, Jones CR, Jones TP, Jost B, Jurik N, Kadavath SHK, Kandybei S, Kang Y, Karacson M, Karpenkov D, Karpov M, Kautz JW, Keizer F, Keller DM, Kenzie M, Ketel T, Khanji B, Kharisova A, Kholodenko S, Kirn T, Kirsebom VS, Kitouni O, Klaver S, Kleijne N, Klimaszewski K, Kmiec MR, Koliiev S, Kondybayeva A, Konoplyannikov A, Kopciewicz P, Kopecna R, Koppenburg P, Korolev M, Kostiuk I, Kot O, Kotriakhova S, Kozachuk A, Kravchenko P, Kravchuk L, Krawczyk RD, Kreps M, Kretzschmar S, Krokovny P, Krupa W, Krzemien W, Kubat J, Kucharczyk M, Kudryavtsev V, Kuindersma HS, Kunde GJ, Kvaratskheliya T, Lacarrere D, Lafferty G, Lai A, Lampis A, Lancierini D, Lane JJ, Lane R, Lanfranchi G, Langenbruch C, Langer J, Lantwin O, Latham T, Lazzari F, Le Gac R, Lee SH, Lefèvre R, Leflat A, Legotin S, Leroy O, Lesiak T, Leverington B, Li H, Li P, Li S, Li Y, Li Z, Liang X, Lin T, Lindner R, Lisovskyi V, Litvinov R, Liu G, Liu H, Liu Q, Liu S, Salvia AL, Loi A, Lollini R, Castro JL, Longstaff I, Lopes JH, Soliño SL, Lovell GH, Lu Y, Lucarelli C, Lucchesi D, Luchuk S, Martinez ML, Lukashenko V, Luo Y, Lupato A, Luppi E, Lupton O, Lusiani A, Lyu X, Ma L, Ma R, Maccolini S, Machefert F, Maciuc F, Macko V, Mackowiak P, Maddrell-Mander S, Madejczyk O, Mohan LRM, Maev O, Maevskiy A, Maisuzenko D, Majewski MW, Malczewski JJ, Malde S, Malecki B, Malinin A, Maltsev T, Malygina H, Manca G, Mancinelli G, Manuzzi D, Marangotto D, Maratas J, Marchand JF, Marconi U, Mariani S, Benito CM, Marinangeli M, Marks J, Marshall AM, Marshall PJ, Martelli G, Martellotti G, Martinazzoli L, Martinelli M, Santos DM, Vidal FM, Massafferri A, Materok M, Matev R, Mathad A, Matiunin V, Matteuzzi C, Mattioli KR, Mauri A, Maurice E, Mauricio J, Mazurek M, McCann M, Mcconnell L, Mcgrath TH, Mchugh NT, McNab A, McNulty R, Mead JV, Meadows B, Meier G, Melnychuk D, Meloni S, Merk M, Merli A, Garcia LM, Mikhasenko M, Milanes DA, Millard E, Milovanovic M, Minard MN, Minotti A, Mitchell SE, Mitreska B, Mitzel DS, Mödden A, Mohammed RA, Moise RD, Mokhnenko S, Mombächer T, Monroy IA, Monteil S, Morandin M, Morello G, Morello MJ, Moron J, Morris AB, Morris AG, Mountain R, Mu H, Muheim F, Mulder M, Müller K, Murphy CH, Murray D, Murta R, Muzzetto P, Naik P, Nakada T, Nandakumar R, Nanut T, Nasteva I, Needham M, Neri N, Neubert S, Neufeld N, Newcombe R, Niel EM, Nieswand S, Nikitin N, Nolte NS, Normand C, Nunez C, Oblakowska-Mucha A, Obraztsov V, Oeser T, O'Hanlon DP, Okamura S, Oldeman R, Oliva F, Olivares ME, Onderwater CJG, O'Neil RH, Goicochea JMO, Ovsiannikova T, Owen P, Oyanguren A, Ozcelik O, Padeken KO, Pagare B, Pais PR, Pajero T, Palano A, Palutan M, Pan Y, Panshin G, Papanestis A, Pappagallo M, Pappalardo LL, Pappenheimer C, Parker W, Parkes C, Passalacqua B, Passaleva G, Pastore A, Patel M, Patrignani C, Pawley CJ, Pearce A, Pellegrino A, Altarelli MP, Perazzini S, Pereima D, Castro AP, Perret P, Petric M, Petridis K, Petrolini A, Petrov A, Petrucci S, Petruzzo M, Pham TTH, Philippov A, Piandani R, Pica L, Piccini M, Pietrzyk B, Pietrzyk G, Pili M, Pinci D, Pisani F, Pizzichemi M, Resmi PK, Placinta V, Plews J, Casasus MP, Polci F, Lener MP, Poliakova M, Poluektov A, Polukhina N, Polyakov I, Polycarpo E, Ponce S, Popov D, Popov S, Poslavskii S, Prasanth K, Promberger L, Prouve C, Pugatch V, Puill V, Punzi G, Qi H, Qian W, Qin N, Quagliani R, Raab NV, Trejo RIR, Rachwal B, Rademacker JH, Rajagopalan R, Rama M, Pernas MR, Rangel MS, Ratnikov F, Raven G, Reboud M, Redi F, Reiss F, Alepuz CR, Ren Z, Renaudin V, Ribatti R, Ricci AM, Ricciardi S, Rinnert K, Robbe P, Robertson G, Rodrigues AB, Rodrigues E, Lopez JAR, Rodriguez ERRR, Rollings A, Roloff P, Romanovskiy V, Lamas MR, Vidal AR, Roth JD, Rotondo M, Rudolph MS, Ruf T, Fernandez RAR, Vidal JR, Ryzhikov A, Ryzka J, Silva JJS, Sagidova N, Sahoo N, Saitta B, Salomoni M, Gras CS, Santacesaria R, Rios CS, Santimaria M, Santovetti E, Saranin D, Sarpis G, Sarpis M, Sarti A, Satriano C, Satta A, Saur M, Savrina D, Sazak H, Smead LGS, Scarabotto A, Schael S, Scherl S, Schiller M, Schindler H, Schmelling M, Schmidt B, Schmitt S, Schneider O, Schopper A, Schubiger M, Schulte S, Schune MH, Schwemmer R, Sciascia B, Sellam S, Semennikov A, Soares MS, Sergi A, Serra N, Sestini L, Seuthe A, Shang Y, Shangase DM, Shapkin M, Shchemerov I, Shchutska L, Shears T, Shekhtman L, Shen Z, Sheng S, Shevchenko V, Shields EB, Shimizu Y, Shmanin E, Shupperd JD, Siddi BG, Coutinho RS, Simi G, Simone S, Skidmore N, Skuza R, Skwarnicki T, Slater MW, Slazyk I, Smallwood JC, Smeaton JG, Smith E, Smith M, Snoch A, Lavra LS, Sokoloff MD, Soler FJP, Solovev A, Solovyev I, De Almeida FLS, De Paula BS, Spaan B, Norella ES, Spradlin P, Stagni F, Stahl M, Stahl S, Stanislaus S, Steinkamp O, Stenyakin O, Stevens H, Stone S, Strekalina D, Suljik F, Sun J, Sun L, Sun Y, Svihra P, Swallow PN, Swientek K, Szabelski A, Szumlak T, Szymanski M, Taneja S, Tanner AR, Tat MD, Terentev A, Teubert F, Thomas E, Thompson DJD, Thomson KA, Tilquin H, Tisserand V, T'Jampens S, Tobin M, Tomassetti L, Tong X, Machado DT, Tou DY, Trifonova E, Trilov SM, Trippl C, Tuci G, Tully A, Tuning N, Ukleja A, Unverzagt DJ, Ursov E, Usachov A, Ustyuzhanin A, Uwer U, Vagner A, Vagnoni V, Valassi A, Valenti G, Canudas NV, van Beuzekom M, Van Dijk M, Van Hecke H, van Herwijnen E, van Veghel M, Gomez RV, Regueiro PV, Sierra CV, Vecchi S, Velthuis JJ, Veltri M, Venkateswaran A, Veronesi M, Vesterinen M, Vieira D, Diaz MV, Viemann H, Vilasis-Cardona X, Figueras EV, Villa A, Vincent P, Volle FC, Bruch DV, Vorobyev A, Vorobyev V, Voropaev N, Vos K, Waldi R, Walsh J, Wang C, Wang J, Wang J, Wang J, Wang J, Wang M, Wang R, Wang Y, Wang Z, Wang Z, Wang Z, Ward JA, Watson NK, Websdale D, Weisser C, Westhenry BDC, White DJ, Whitehead M, Wiederhold AR, Wiedner D, Wilkinson G, Wilkinson MK, Williams I, Williams M, Williams MRJ, Wilson FF, Wislicki W, Witek M, Witola L, Wormser G, Wotton SA, Wu H, Wyllie K, Xiang Z, Xiao D, Xie Y, Xu A, Xu J, Xu L, Xu M, Xu Q, Xu Z, Xu Z, Yang D, Yang S, Yang Y, Yang Z, Yang Z, Yao Y, Yeomans LE, Yin H, Yu J, Yuan X, Yushchenko O, Zaffaroni E, Zavertyaev M, Zdybal M, Zenaiev O, Zeng M, Zhang D, Zhang L, Zhang S, Zhang S, Zhang Y, Zhang Y, Zharkova A, Zhelezov A, Zheng Y, Zhou T, Zhou X, Zhou Y, Zhovkovska V, Zhu X, Zhu X, Zhu Z, Zhukov V, Zou Q, Zucchelli S, Zuliani D, and Zunica G
Abstract: The first observation of the semileptonic b-baryon decay Λ_{b}^{0}→Λ_{c}^{+}τ^{-}ν[over ¯]_{τ}, with a significance of 6.1σ, is reported using a data sample corresponding to 3 fb^{-1} of integrated luminosity, collected by the LHCb experiment at center-of-mass energies of 7 and 8 TeV at the LHC. The τ^{-} lepton is reconstructed in the hadronic decay to three charged pions. The ratio K=B(Λ_{b}^{0}→Λ_{c}^{+}τ^{-}ν[over ¯]_{τ})/B(Λ_{b}^{0}→Λ_{c}^{+}π^{-}π^{+}π^{-}) is measured to be 2.46±0.27±0.40, where the first uncertainty is statistical and the second systematic. The branching fraction B(Λ_{b}^{0}→Λ_{c}^{+}τ^{-}ν[over ¯]_{τ})=(1.50±0.16±0.25±0.23)% is obtained, where the third uncertainty is from the external branching fraction of the normalization channel Λ_{b}^{0}→Λ_{c}^{+}π^{-}π^{+}π^{-}. The ratio of semileptonic branching fractions R(Λ_{c}^{+})≡B(Λ_{b}^{0}→Λ_{c}^{+}τ^{-}ν[over ¯]_{τ})/B(Λ_{b}^{0}→Λ_{c}^{+}μ^{-}ν[over ¯]_{μ}) is derived to be 0.242±0.026±0.040±0.059, where the external branching fraction uncertainty from the channel Λ_{b}^{0}→Λ_{c}^{+}μ^{-}ν[over ¯]_{μ} contributes to the last term. This result is in agreement with the standard model prediction.
Published: 2022
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7. Study of Z Bosons Produced in Association with Charm in the Forward Region.

Author: Aaij R, Abdelmotteleb ASW, Beteta CA, Gallego FJA, Ackernley T, Adeva B, Adinolfi M, Afsharnia H, Agapopoulou C, Aidala CA, Aiola S, Ajaltouni Z, Akar S, Albrecht J, Alessio F, Alexander M, Albero AA, Aliouche Z, Alkhazov G, Cartelle PA, Amato S, Amey JL, Amhis Y, An L, Anderlini L, Andreianov A, Andreotti M, Archilli F, Artamonov A, Artuso M, Arzymatov K, Aslanides E, Atzeni M, Audurier B, Bachmann S, Bachmayer M, Back JJ, Rodriguez PB, Balagura V, Baldini W, Leite JB, Barbetti M, Barlow RJ, Barsuk S, Barter W, Bartolini M, Baryshnikov F, Basels JM, Bashir S, Bassi G, Batsukh B, Battig A, Bay A, Beck A, Becker M, Bedeschi F, Bediaga I, Beiter A, Belavin V, Belin S, Bellee V, Belous K, Belov I, Belyaev I, Bencivenni G, Ben-Haim E, Berezhnoy A, Bernet R, Berninghoff D, Bernstein HC, Bertella C, Bertolin A, Betancourt C, Betti F, Bezshyiko I, Bhasin S, Bhom J, Bian L, Bieker MS, Bifani S, Billoir P, Birch M, Bishop FCR, Bitadze A, Bizzeti A, Bjørn M, Blago MP, Blake T, Blanc F, Blusk S, Bobulska D, Boelhauve JA, Garcia OB, Boettcher T, Boldyrev A, Bondar A, Bondar N, Borghi S, Borisyak M, Borsato M, Borsuk JT, Bouchiba SA, Bowcock TJV, Boyer A, Bozzi C, Bradley MJ, Braun S, Rodriguez AB, Brodzicka J, Gonzalo AB, Brundu D, Buonaura A, Buonincontri L, Burke AT, Burr C, Bursche A, Butkevich A, Butter JS, Buytaert J, Byczynski W, Cadeddu S, Cai H, Calabrese R, Calefice L, Diaz LC, Cali S, Calladine R, Calvi M, Gomez MC, Magalhaes PC, Campana P, Quezada AFC, Capelli S, Capriotti L, Carbone A, Carboni G, Cardinale R, Cardini A, Carli I, Carniti P, Carus L, Akiba KC, Vidal AC, Casse G, Cattaneo M, Cavallero G, Celani S, Cerasoli J, Cervenkov D, Chadwick AJ, Chapman MG, Charles M, Charpentier P, Chatzikonstantinidis G, Barajas CAC, Chefdeville M, Chen C, Chen S, Chernov A, Chobanova V, Cholak S, Chrzaszcz M, Chubykin A, Chulikov V, Ciambrone P, Cicala MF, Vidal XC, Ciezarek G, Clarke PEL, Clemencic M, Cliff HV, Closier J, Cobbledick JL, Coco V, Coelho JAB, Cogan J, Cogneras E, Cojocariu L, Collins P, Colombo T, Congedo L, Contu A, Cooke N, Coombs G, Corredoira I, Corti G, Sobral CMC, Couturier B, Craik DC, Crkovská J, Torres MC, Currie R, Da Silva CL, Dadabaev S, Dai L, Dall'Occo E, Dalseno J, D'Ambrosio C, Danilina A, d'Argent P, Davies JE, Davis A, Francisco OA, De Bruyn K, De Capua S, De Cian M, De Miranda JM, De Paula L, De Serio M, De Simone D, De Simone P, De Vellis F, de Vries JA, Dean CT, Debernardis F, Decamp D, Dedu V, Del Buono L, Delaney B, Dembinski HP, Dendek A, Denysenko V, Derkach D, Deschamps O, Desse F, Dettori F, Dey B, Di Cicco A, Di Nezza P, Didenko S, Maronas LD, Dijkstra H, Dobishuk V, Dong C, Donohoe AM, Dordei F, Dos Reis AC, Douglas L, Dovbnya A, Downes AG, Dudek MW, Dufour L, Duk V, Durante P, Durham JM, Dutta D, Dziurda A, Dzyuba A, Easo S, Egede U, Egorychev V, Eidelman S, Eisenhardt S, Ek-In S, Eklund L, Ely S, Ene A, Epple E, Escher S, Eschle J, Esen S, Evans T, Falabella A, Fan J, Fan Y, Fang B, Farry S, Fazzini D, Féo M, Prieto AF, Fernez AD, Ferrari F, Lopes LF, Rodrigues FF, Sole SF, Ferrillo M, Ferro-Luzzi M, Filippov S, Fini RA, Fiorini M, Firlej M, Fischer KM, Fitzgerald DS, Fitzpatrick C, Fiutowski T, Fkiaras A, Fleuret F, Fontana M, Fontanelli F, Forty R, Foulds-Holt D, Lima VF, Sevilla MF, Frank M, Franzoso E, Frau G, Frei C, Friday DA, Fu J, Fuehring Q, Gabriel E, Galati G, Torreira AG, Galli D, Gambetta S, Gan Y, Gandelman M, Gandini P, Gao Y, Garau M, Martin LMG, Moreno PG, Pardiñas JG, Plana BG, Rosales FAG, Garrido L, Gaspar C, Geertsema RE, Gerick D, Gerken LL, Gersabeck E, Gersabeck M, Gershon T, Gerstel D, Giambastiani L, Gibson V, Giemza HK, Gilman AL, Giovannetti M, Gioventù A, Gironell PG, Giubega L, Giugliano C, Gizdov K, Gkougkousis EL, Gligorov VV, Göbel C, Golobardes E, Golubkov D, Golutvin A, Gomes A, Fernandez SG, Abrantes FG, Goncerz M, Gong G, Gorbounov P, Gorelov IV, Gotti C, Govorkova E, Grabowski JP, Grammatico T, Cardoso LAG, Graugés E, Graverini E, Graziani G, Grecu A, Greeven LM, Grieser NA, Grillo L, Gromov S, Cazon BRG, Gu C, Guarise M, Guittiere M, Günther PA, Gushchin E, Guth A, Guz Y, Gys T, Hadavizadeh T, Haefeli G, Haen C, Haimberger J, Halewood-Leagas T, Hamilton PM, Hammerich JP, Han Q, Han X, Hancock TH, Hansen EB, Hansmann-Menzemer S, Harnew N, Harrison T, Hasse C, Hatch M, He J, Hecker M, Heijhoff K, Heinicke K, Hennequin AM, Hennessy K, Henry L, Heuel J, Hicheur A, Hill D, Hilton M, Hollitt SE, Hou R, Hou Y, Hu J, Hu J, Hu W, Hu X, Huang W, Huang X, Hulsbergen W, Hunter RJ, Hushchyn M, Hutchcroft D, Hynds D, Ibis P, Idzik M, Ilin D, Ilten P, Inglessi A, Ishteev A, Ivshin K, Jacobsson R, Jage H, Jakobsen S, Jans E, Jashal BK, Jawahery A, Jevtic V, Jiang F, John M, Johnson D, Jones CR, Jones TP, Jost B, Jurik N, Kadavath SHK, Kandybei S, Kang Y, Karacson M, Karpov M, Keizer F, Keller DM, Kenzie M, Ketel T, Khanji B, Kharisova A, Kholodenko S, Kirn T, Kirsebom VS, Kitouni O, Klaver S, Kleijne N, Klimaszewski K, Kmiec MR, Koliiev S, Kondybayeva A, Konoplyannikov A, Kopciewicz P, Kopecna R, Koppenburg P, Korolev M, Kostiuk I, Kot O, Kotriakhova S, Kravchenko P, Kravchuk L, Krawczyk RD, Kreps M, Kress F, Kretzschmar S, Krokovny P, Krupa W, Krzemien W, Kucharczyk M, Kudryavtsev V, Kuindersma HS, Kunde GJ, Kvaratskheliya T, Lacarrere D, Lafferty G, Lai A, Lampis A, Lancierini D, Lane JJ, Lane R, Lanfranchi G, Langenbruch C, Langer J, Lantwin O, Latham T, Lazzari F, Le Gac R, Lee SH, Lefèvre R, Leflat A, Legotin S, Leroy O, Lesiak T, Leverington B, Li H, Li P, Li S, Li Y, Li Y, Li Z, Liang X, Lin T, Lindner R, Lisovskyi V, Litvinov R, Liu G, Liu H, Liu Q, Liu S, Salvia AL, Loi A, Castro JL, Longstaff I, Lopes JH, Solino SL, Lovell GH, Lu Y, Lucarelli C, Lucchesi D, Luchuk S, Martinez ML, Lukashenko V, Luo Y, Lupato A, Luppi E, Lupton O, Lusiani A, Lyu X, Ma L, Ma R, Maccolini S, Machefert F, Maciuc F, Macko V, Mackowiak P, Maddrell-Mander S, Madejczyk O, Mohan LRM, Maev O, Maevskiy A, Maisuzenko D, Majewski MW, Malczewski JJ, Malde S, Malecki B, Malinin A, Maltsev T, Malygina H, Manca G, Mancinelli G, Manuzzi D, Marangotto D, Maratas J, Marchand JF, Marconi U, Mariani S, Benito CM, Marinangeli M, Marks J, Marshall AM, Marshall PJ, Martelli G, Martellotti G, Martinazzoli L, Martinelli M, Santos DM, Vidal FM, Massafferri A, Materok M, Matev R, Mathad A, Matiunin V, Matteuzzi C, Mattioli KR, Mauri A, Maurice E, Mauricio J, Mazurek M, McCann M, Mcconnell L, Mcgrath TH, Mchugh NT, McNab A, McNulty R, Mead JV, Meadows B, Meier G, Meinert N, Melnychuk D, Meloni S, Merk M, Merli A, Garcia LM, Mikhasenko M, Milanes DA, Millard E, Milovanovic M, Minard MN, Minotti A, Minzoni L, Mitchell SE, Mitreska B, Mitzel DS, Mödden A, Mohammed RA, Moise RD, Mokhnenko S, Mombächer T, Monroy IA, Monteil S, Morandin M, Morello G, Morello MJ, Moron J, Morris AB, Morris AG, Mountain R, Mu H, Muheim F, Mulder M, Müller D, Müller K, Murphy CH, Murray D, Muzzetto P, Naik P, Nakada T, Nandakumar R, Nanut T, Nasteva I, Needham M, Neri I, Neri N, Neubert S, Neufeld N, Newcombe R, Niel EM, Nieswand S, Nikitin N, Nolte NS, Normand C, Nunez C, Oblakowska-Mucha A, Obraztsov V, Oeser T, O'Hanlon DP, Okamura S, Oldeman R, Oliva F, Olivares ME, Onderwater CJG, O'Neil RH, Goicochea JMO, Ovsiannikova T, Owen P, Oyanguren A, Padeken KO, Pagare B, Pais PR, Pajero T, Palano A, Palutan M, Pan Y, Panshin G, Papanestis A, Pappagallo M, Pappalardo LL, Pappenheimer C, Parker W, Parkes C, Passalacqua B, Passaleva G, Pastore A, Patel M, Patrignani C, Pawley CJ, Pearce A, Pellegrino A, Altarelli MP, Perazzini S, Pereima D, Castro AP, Perret P, Petric M, Petridis K, Petrolini A, Petrov A, Petrucci S, Petruzzo M, Pham TTH, Philippov A, Pica L, Piccini M, Pietrzyk B, Pietrzyk G, Pili M, Pinci D, Pisani F, Pizzichemi M, K RP, Placinta V, Plews J, Casasus MP, Polci F, Lener MP, Poliakova M, Poluektov A, Polukhina N, Polyakov I, Polycarpo E, Ponce S, Popov D, Popov S, Poslavskii S, Prasanth K, Promberger L, Prouve C, Pugatch V, Puill V, Pullen H, Punzi G, Qi H, Qian W, Qin J, Qin N, Quagliani R, Quintana B, Raab NV, Trejo RIR, Rachwal B, Rademacker JH, Rama M, Pernas MR, Rangel MS, Ratnikov F, Raven G, Reboud M, Redi F, Reiss F, Alepuz CR, Ren Z, Renaudin V, Ribatti R, Ricciardi S, Rinnert K, Robbe P, Robertson G, Rodrigues AB, Rodrigues E, Lopez JAR, Rodriguez ERRR, Rollings A, Roloff P, Romanovskiy V, Lamas MR, Vidal AR, Roth JD, Rotondo M, Rudolph MS, Ruf T, Fernandez RAR, Vidal JR, Ryzhikov A, Ryzka J, Silva JJS, Sagidova N, Sahoo N, Saitta B, Salomoni M, Gras CS, Santacesaria R, Rios CS, Santimaria M, Santovetti E, Saranin D, Sarpis G, Sarpis M, Sarti A, Satriano C, Satta A, Saur M, Savrina D, Sazak H, Smead LGS, Scarabotto A, Schael S, Scherl S, Schiller M, Schindler H, Schmelling M, Schmidt B, Schmitt S, Schneider O, Schopper A, Schubiger M, Schulte S, Schune MH, Schwemmer R, Sciascia B, Sellam S, Semennikov A, Soares MS, Sergi A, Serra N, Sestini L, Seuthe A, Shang Y, Shangase DM, Shapkin M, Shchemerov I, Shchutska L, Shears T, Shekhtman L, Shen Z, Shevchenko V, Shields EB, Shimizu Y, Shmanin E, Shupperd JD, Siddi BG, Coutinho RS, Simi G, Simone S, Skidmore N, Skwarnicki T, Slater MW, Slazyk I, Smallwood JC, Smeaton JG, Smetkina A, Smith E, Smith M, Snoch A, Soares M, Lavra LS, Sokoloff MD, Soler FJP, Solovev A, Solovyev I, De Almeida FLS, De Paula BS, Spaan B, Norella ES, Spradlin P, Stagni F, Stahl M, Stahl S, Stanislaus S, Steinkamp O, Stenyakin O, Stevens H, Stone S, Straticiuc M, Strekalina D, Suljik F, Sun J, Sun L, Sun Y, Svihra P, Swallow PN, Swientek K, Szabelski A, Szumlak T, Szymanski M, Taneja S, Tanner AR, Tat MD, Terentev A, Teubert F, Thomas E, Thompson DJD, Thomson KA, Tisserand V, T'Jampens S, Tobin M, Tomassetti L, Tong X, Machado DT, Tou DY, Trifonova E, Trippl C, Tuci G, Tully A, Tuning N, Ukleja A, Unverzagt DJ, Ursov E, Usachov A, Ustyuzhanin A, Uwer U, Vagner A, Vagnoni V, Valassi A, Valenti G, Canudas NV, van Beuzekom M, Van Dijk M, Van Hecke H, van Herwijnen E, Van Hulse CB, van Veghel M, Gomez RV, Regueiro PV, Sierra CV, Vecchi S, Velthuis JJ, Veltri M, Venkateswaran A, Veronesi M, Vesterinen M, Vieira D, Diaz MV, Viemann H, Vilasis-Cardona X, Figueras EV, Villa A, Vincent P, Volle FC, Bruch DV, Vorobyev A, Vorobyev V, Voropaev N, Vos K, Waldi R, Walsh J, Wang C, Wang J, Wang J, Wang J, Wang J, Wang M, Wang R, Wang Y, Wang Z, Wang Z, Wang Z, Ward JA, Watson NK, Weber SG, Websdale D, Weisser C, Westhenry BDC, White DJ, Whitehead M, Wiederhold AR, Wiedner D, Wilkinson G, Wilkinson M, Williams I, Williams M, Williams MRJ, Wilson FF, Wislicki W, Witek M, Witola L, Wormser G, Wotton SA, Wu H, Wyllie K, Xiang Z, Xiao D, Xie Y, Xu A, Xu J, Xu L, Xu M, Xu Q, Xu Z, Xu Z, Yang D, Yang S, Yang Y, Yang Z, Yang Z, Yao Y, Yeomans LE, Yin H, Yu J, Yuan X, Yushchenko O, Zaffaroni E, Zavertyaev M, Zdybal M, Zenaiev O, Zeng M, Zhang D, Zhang L, Zhang S, Zhang S, Zhang Y, Zhang Y, Zharkova A, Zhelezov A, Zheng Y, Zhou T, Zhou X, Zhou Y, Zhovkovska V, Zhu X, Zhu X, Zhu Z, Zhukov V, Zonneveld JB, Zou Q, Zucchelli S, Zuliani D, and Zunica G
Abstract: Events containing a Z boson and a charm jet are studied for the first time in the forward region of proton-proton collisions. The data sample used corresponds to an integrated luminosity of 6 fb^{-1} collected at a center-of-mass energy of 13 TeV with the LHCb detector. In events with a Z boson and a jet, the fraction of charm jets is determined in intervals of Z-boson rapidity in the range 2.0
Published: 2022
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8. Nucleus-cytoskeleton communication impacts on OCT4-chromatin interactions in embryonic stem cells.

Author: Romero JJ, De Rossi MC, Oses C, Echegaray CV, Verneri P, Francia M, Guberman A, and Levi V
Subjects: Cell Differentiation, Cytoskeleton metabolism, Embryonic Stem Cells metabolism, Octamer Transcription Factor-3 genetics, Octamer Transcription Factor-3 metabolism, Vimentin metabolism, Actins metabolism, Chromatin metabolism
Abstract: Background: The cytoskeleton is a key component of the system responsible for transmitting mechanical cues from the cellular environment to the nucleus, where they trigger downstream responses. This communication is particularly relevant in embryonic stem (ES) cells since forces can regulate cell fate and guide developmental processes. However, little is known regarding cytoskeleton organization in ES cells, and thus, relevant aspects of nuclear-cytoskeletal interactions remain elusive., Results: We explored the three-dimensional distribution of the cytoskeleton in live ES cells and show that these filaments affect the shape of the nucleus. Next, we evaluated if cytoskeletal components indirectly modulate the binding of the pluripotency transcription factor OCT4 to chromatin targets. We show that actin depolymerization triggers OCT4 binding to chromatin sites whereas vimentin disruption produces the opposite effect. In contrast to actin, vimentin contributes to the preservation of OCT4-chromatin interactions and, consequently, may have a pro-stemness role., Conclusions: Our results suggest roles of components of the cytoskeleton in shaping the nucleus of ES cells, influencing the interactions of the transcription factor OCT4 with the chromatin and potentially affecting pluripotency and cell fate., (© 2021. The Author(s).)
Published: 2022
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9. Observation of the Mass Difference between Neutral Charm-Meson Eigenstates.

Author: Aaij R, Beteta CA, Ackernley T, Adeva B, Adinolfi M, Afsharnia H, Aidala CA, Aiola S, Ajaltouni Z, Akar S, Albrecht J, Alessio F, Alexander M, Albero AA, Aliouche Z, Alkhazov G, Cartelle PA, Amato S, Amhis Y, An L, Anderlini L, Andreianov A, Andreotti M, Archilli F, Artamonov A, Artuso M, Arzymatov K, Aslanides E, Atzeni M, Audurier B, Bachmann S, Bachmayer M, Back JJ, Rodriguez PB, Balagura V, Baldini W, Leite JB, Barlow RJ, Barsuk S, Barter W, Bartolini M, Baryshnikov F, Basels JM, Bassi G, Batsukh B, Battig A, Bay A, Becker M, Bedeschi F, Bediaga I, Beiter A, Belavin V, Belin S, Bellee V, Belous K, Belov I, Belyaev I, Bencivenni G, Ben-Haim E, Berezhnoy A, Bernet R, Berninghoff D, Bernstein HC, Bertella C, Bertolin A, Betancourt C, Betti F, Bezshyiko I, Bhasin S, Bhom J, Bian L, Bieker MS, Bifani S, Billoir P, Birch M, Bishop FCR, Bitadze A, Bizzeti A, Bjørn M, Blago MP, Blake T, Blanc F, Blusk S, Bobulska D, Boelhauve JA, Garcia OB, Boettcher T, Boldyrev A, Bondar A, Bondar N, Borghi S, Borisyak M, Borsato M, Borsuk JT, Bouchiba SA, Bowcock TJV, Boyer A, Bozzi C, Bradley MJ, Braun S, Rodriguez AB, Brodski M, Brodzicka J, Gonzalo AB, Brundu D, Buonaura A, Burr C, Bursche A, Butkevich A, Butter JS, Buytaert J, Byczynski W, Cadeddu S, Cai H, Calabrese R, Calefice L, Diaz LC, Cali S, Calladine R, Calvi M, Gomez MC, Magalhaes PC, Campana P, Quezada AFC, Capelli S, Capriotti L, Carbone A, Carboni G, Cardinale R, Cardini A, Carli I, Carniti P, Carus L, Akiba KC, Vidal AC, Casse G, Cattaneo M, Cavallero G, Celani S, Cerasoli J, Chadwick AJ, Chapman MG, Charles M, Charpentier P, Chatzikonstantinidis G, Barajas CAC, Chefdeville M, Chen C, Chen S, Chernov A, Chobanova V, Cholak S, Chrzaszcz M, Chubykin A, Chulikov V, Ciambrone P, Cicala MF, Vidal XC, Ciezarek G, Clarke PEL, Clemencic M, Cliff HV, Closier J, Cobbledick JL, Coco V, Coelho JAB, Cogan J, Cogneras E, Cojocariu L, Collins P, Colombo T, Congedo L, Contu A, Cooke N, Coombs G, Corti G, Sobral CMC, Couturier B, Craik DC, Crkovská J, Torres MC, Currie R, Da Silva CL, Dadabaev S, Dall'Occo E, Dalseno J, D'Ambrosio C, Danilina A, d'Argent P, Davis A, Francisco OA, De Bruyn K, De Capua S, De Cian M, De Miranda JM, De Paula L, De Serio M, De Simone D, De Simone P, de Vries JA, Dean CT, Decamp D, Del Buono L, Delaney B, Dembinski HP, Dendek A, Denysenko V, Derkach D, Deschamps O, Desse F, Dettori F, Dey B, Di Canto A, Di Cicco A, Di Nezza P, Didenko S, Maronas LD, Dijkstra H, Dobishuk V, Donohoe AM, Dordei F, Dos Reis AC, Douglas L, Dovbnya A, Downes AG, Dreimanis K, Dudek MW, Dufour L, Duk V, Durante P, Durham JM, Dutta D, Dziurda A, Dzyuba A, Easo S, Egede U, Egorychev V, Eidelman S, Eisenhardt S, Ek-In S, Eklund L, Ely S, Ene A, Epple E, Escher S, Eschle J, Esen S, Evans T, Falabella A, Fan J, Fan Y, Fang B, Farry S, Fazzini D, Féo M, Prieto AF, Arribas JMF, Fernez AD, Ferrari F, Lopes LF, Rodrigues FF, Sole SF, Ferrillo M, Ferro-Luzzi M, Filippov S, Fini RA, Fiorini M, Firlej M, Fischer KM, Fitzgerald DS, Fitzpatrick C, Fiutowski T, Fkiaras A, Fleuret F, Fontana M, Fontanelli F, Forty R, Lima VF, Sevilla MF, Frank M, Franzoso E, Frau G, Frei C, Friday DA, Fu J, Fuehring Q, Funk W, Gabriel E, Gaintseva T, Torreira AG, Galli D, Gambetta S, Gan Y, Gandelman M, Gandini P, Gao Y, Garau M, Martin LMG, Moreno PG, Pardiñas JG, Plana BG, Rosales FAG, Garrido L, Gaspar C, Geertsema RE, Gerick D, Gerken LL, Gersabeck E, Gersabeck M, Gershon T, Gerstel D, Ghez P, Gibson V, Giemza HK, Giovannetti M, Gioventù A, Gironell PG, Giubega L, Giugliano C, Gizdov K, Gkougkousis EL, Gligorov VV, Göbel C, Golobardes E, Golubkov D, Golutvin A, Gomes A, Fernandez SG, Abrantes FG, Goncerz M, Gong G, Gorbounov P, Gorelov IV, Gotti C, Govorkova E, Grabowski JP, Grammatico T, Cardoso LAG, Graugés E, Graverini E, Graziani G, Grecu A, Greeven LM, Griffith P, Grillo L, Gromov S, Cazon BRG, Gu C, Guarise M, Günther PA, Gushchin E, Guth A, Guz Y, Gys T, Hadavizadeh T, Haefeli G, Haen C, Haimberger J, Halewood-Leagas T, Hamilton PM, Hammerich JP, Han Q, Han X, Hancock TH, Hansmann-Menzemer S, Harnew N, Harrison T, Hasse C, Hatch M, He J, Hecker M, Heijhoff K, Heinicke K, Hennequin AM, Hennessy K, Henry L, Heuel J, Hicheur A, Hill D, Hilton M, Hollitt SE, Hu J, Hu J, Hu W, Hu X, Huang W, Huang X, Hulsbergen W, Hunter RJ, Hushchyn M, Hutchcroft D, Hynds D, Ibis P, Idzik M, Ilin D, Ilten P, Inglessi A, Ishteev A, Ivshin K, Jacobsson R, Jakobsen S, Jans E, Jashal BK, Jawahery A, Jevtic V, Jezabek M, Jiang F, John M, Johnson D, Jones CR, Jones TP, Jost B, Jurik N, Kandybei S, Kang Y, Karacson M, Karpov M, Keizer F, Kenzie M, Ketel T, Khanji B, Kharisova A, Kholodenko S, Kirn T, Kirsebom VS, Kitouni O, Klaver S, Klimaszewski K, Koliiev S, Kondybayeva A, Konoplyannikov A, Kopciewicz P, Kopecna R, Koppenburg P, Korolev M, Kostiuk I, Kot O, Kotriakhova S, Kravchenko P, Kravchuk L, Krawczyk RD, Kreps M, Kress F, Kretzschmar S, Krokovny P, Krupa W, Krzemien W, Kucewicz W, Kucharczyk M, Kudryavtsev V, Kuindersma HS, Kunde GJ, Kvaratskheliya T, Lacarrere D, Lafferty G, Lai A, Lampis A, Lancierini D, Lane JJ, Lane R, Lanfranchi G, Langenbruch C, Langer J, Lantwin O, Latham T, Lazzari F, Le Gac R, Lee SH, Lefèvre R, Leflat A, Legotin S, Leroy O, Lesiak T, Leverington B, Li H, Li L, Li P, Li S, Li Y, Li Y, Li Z, Liang X, Lin T, Lindner R, Lisovskyi V, Litvinov R, Liu G, Liu H, Liu S, Loi A, Castro JL, Longstaff I, Lopes JH, Lovell GH, Lu Y, Lucchesi D, Luchuk S, Martinez ML, Lukashenko V, Luo Y, Lupato A, Luppi E, Lupton O, Lusiani A, Lyu X, Ma L, Ma R, Maccolini S, Machefert F, Maciuc F, Macko V, Mackowiak P, Maddrell-Mander S, Madejczyk O, Mohan LRM, Maev O, Maevskiy A, Maisuzenko D, Majewski MW, Malczewski JJ, Malde S, Malecki B, Malinin A, Maltsev T, Malygina H, Manca G, Mancinelli G, Manuzzi D, Marangotto D, Maratas J, Marchand JF, Marconi U, Mariani S, Benito CM, Marinangeli M, Marks J, Marshall AM, Marshall PJ, Martellotti G, Martinazzoli L, Martinelli M, Santos DM, Vidal FM, Massafferri A, Materok M, Matev R, Mathad A, Mathe Z, Matiunin V, Matteuzzi C, Mattioli KR, Mauri A, Maurice E, Mauricio J, Mazurek M, McCann M, Mcconnell L, Mcgrath TH, McNab A, McNulty R, Mead JV, Meadows B, Meier G, Meinert N, Melnychuk D, Meloni S, Merk M, Merli A, Garcia LM, Mikhasenko M, Milanes DA, Millard E, Milovanovic M, Minard MN, Minotti A, Minzoni L, Mitchell SE, Mitreska B, Mitzel DS, Mödden A, Mohammed RA, Moise RD, Mombächer T, Monroy IA, Monteil S, Morandin M, Morello G, Morello MJ, Moron J, Morris AB, Morris AG, Mountain R, Mu H, Muheim F, Mulder M, Müller D, Müller K, Murphy CH, Murray D, Muzzetto P, Naik P, Nakada T, Nandakumar R, Nanut T, Nasteva I, Needham M, Neri I, Neri N, Neubert S, Neufeld N, Newcombe R, Nguyen TD, Nguyen-Mau C, Niel EM, Nieswand S, Nikitin N, Nolte NS, Normand C, Nunez C, Oblakowska-Mucha A, Obraztsov V, O'Hanlon DP, Oldeman R, Olivares ME, Onderwater CJG, O'neil RH, Ossowska A, Goicochea JMO, Ovsiannikova T, Owen P, Oyanguren A, Pagare B, Pais PR, Pajero T, Palano A, Palutan M, Pan Y, Panshin G, Papanestis A, Pappagallo M, Pappalardo LL, Pappenheimer C, Parker W, Parkes C, Parkinson CJ, Passalacqua B, Passaleva G, Pastore A, Patel M, Patrignani C, Pawley CJ, Pearce A, Pellegrino A, Altarelli MP, Perazzini S, Pereima D, Perret P, Petrenko I, Petric M, Petridis K, Petrolini A, Petrov A, Petrucci S, Petruzzo M, Pham TTH, Philippov A, Pica L, Piccini M, Pietrzyk B, Pietrzyk G, Pili M, Pinci D, Pisani F, K RP, Placinta V, Plews J, Casasus MP, Polci F, Lener MP, Poliakova M, Poluektov A, Polukhina N, Polyakov I, Polycarpo E, Pomery GJ, Ponce S, Popov D, Popov S, Poslavskii S, Prasanth K, Promberger L, Prouve C, Pugatch V, Pullen H, Punzi G, Qi H, Qian W, Qin J, Qin N, Quagliani R, Quintana B, Raab NV, Trejo RIR, Rachwal B, Rademacker JH, Rama M, Pernas MR, Rangel MS, Ratnikov F, Raven G, Reboud M, Redi F, Reiss F, Alepuz CR, Ren Z, Renaudin V, Ribatti R, Ricciardi S, Rinnert K, Robbe P, Robertson G, Rodrigues AB, Rodrigues E, Lopez JAR, Rollings A, Roloff P, Romanovskiy V, Lamas MR, Vidal AR, Roth JD, Rotondo M, Rudolph MS, Ruf T, Vidal JR, Ryzhikov A, Ryzka J, Silva JJS, Sagidova N, Sahoo N, Saitta B, Salomoni M, Gonzalo DS, Gras CS, Santacesaria R, Rios CS, Santimaria M, Santovetti E, Saranin D, Sarpis G, Sarpis M, Sarti A, Satriano C, Satta A, Saur M, Savrina D, Sazak H, Smead LGS, Scarabotto A, Schael S, Schiller M, Schindler H, Schmelling M, Schmidt B, Schneider O, Schopper A, Schubiger M, Schulte S, Schune MH, Schwemmer R, Sciascia B, Sellam S, Semennikov A, Soares MS, Sergi A, Serra N, Sestini L, Seuthe A, Seyfert P, Shang Y, Shangase DM, Shapkin M, Shchemerov I, Shchutska L, Shears T, Shekhtman L, Shen Z, Shevchenko V, Shields EB, Shmanin E, Shupperd JD, Siddi BG, Coutinho RS, Simi G, Simone S, Skidmore N, Skwarnicki T, Slater MW, Slazyk I, Smallwood JC, Smeaton JG, Smetkina A, Smith E, Smith M, Snoch A, Soares M, Lavra LS, Sokoloff MD, Soler FJP, Solovev A, Solovyev I, De Almeida FLS, De Paula BS, Spaan B, Norella ES, Spradlin P, Stagni F, Stahl M, Stahl S, Stefko P, Steinkamp O, Stenyakin O, Stevens H, Stone S, Stramaglia ME, Straticiuc M, Strekalina D, Suljik F, Sun J, Sun L, Sun Y, Svihra P, Swallow PN, Swientek K, Szabelski A, Szumlak T, Szymanski M, Taneja S, Tanner AR, Terentev A, Teubert F, Thomas E, Thomson KA, Tisserand V, T'Jampens S, Tobin M, Tomassetti L, Machado DT, Tou DY, Tran MT, Trifonova E, Trippl C, Tuci G, Tully A, Tuning N, Ukleja A, Unverzagt DJ, Ursov E, Usachov A, Ustyuzhanin A, Uwer U, Vagner A, Vagnoni V, Valassi A, Valenti G, Canudas NV, van Beuzekom M, Van Dijk M, van Herwijnen E, Van Hulse CB, van Veghel M, Gomez RV, Regueiro PV, Sierra CV, Vecchi S, Velthuis JJ, Veltri M, Venkateswaran A, Veronesi M, Vesterinen M, Vieira D, Diaz MV, Viemann H, Vilasis-Cardona X, Figueras EV, Villa A, Vincent P, Bruch DV, Vorobyev A, Vorobyev V, Voropaev N, Vos K, Waldi R, Walsh J, Wang C, Wang J, Wang J, Wang J, Wang J, Wang M, Wang R, Wang Y, Wang Z, Wang Z, Wark HM, Watson NK, Weber SG, Websdale D, Weisser C, Westhenry BDC, White DJ, Whitehead M, Wiedner D, Wilkinson G, Wilkinson M, Williams I, Williams M, Williams MRJ, Wilson FF, Wislicki W, Witek M, Witola L, Wormser G, Wotton SA, Wu H, Wyllie K, Xiang Z, Xiao D, Xie Y, Xu A, Xu J, Xu L, Xu M, Xu Q, Xu Z, Xu Z, Yang D, Yang S, Yang Y, Yang Z, Yang Z, Yao Y, Yeomans LE, Yin H, Yu J, Yuan X, Yushchenko O, Zaffaroni E, Zavertyaev M, Zdybal M, Zenaiev O, Zeng M, Zhang D, Zhang L, Zhang S, Zhang Y, Zhang Y, Zharkova A, Zhelezov A, Zheng Y, Zhou X, Zhou Y, Zhu X, Zhu Z, Zhukov V, Zonneveld JB, Zou Q, Zucchelli S, Zuliani D, and Zunica G
Abstract: A measurement of mixing and CP violation in neutral charm mesons is performed using data reconstructed in proton-proton collisions collected by the LHCb experiment from 2016 to 2018, corresponding to an integrated luminosity of 5.4 fb^{-1}. A total of 30.6 million D^{0}→K_{S}^{0}π^{+}π^{-} decays are analyzed using a method optimized for the measurement of the mass difference between neutral charm-meson eigenstates. Allowing for CP violation in mixing and in the interference between mixing and decay, the mass and decay-width differences are measured to be x_{CP}=[3.97±0.46(stat)±0.29(syst)]×10^{-3} and y_{CP}=[4.59±1.20(stat)±0.85(syst)]×10^{-3}, respectively. The CP-violating parameters are measured as Δx=[-0.27±0.18(stat)±0.01(syst)]×10^{-3} and Δy=[0.20±0.36(stat)±0.13(syst)]×10^{-3}. This is the first observation of a nonzero mass difference in the D^{0} meson system, with a significance exceeding seven standard deviations. The data are consistent with CP symmetry and improve existing constraints on the associated parameters.
Published: 2021
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10. Angular Analysis of the B^{+}→K^{*+}μ^{+}μ^{-} Decay.

Author: Aaij R, Beteta CA, Ackernley T, Adeva B, Adinolfi M, Afsharnia H, Aidala CA, Aiola S, Ajaltouni Z, Akar S, Albrecht J, Alessio F, Alexander M, Albero AA, Aliouche Z, Alkhazov G, Cartelle PA, Amato S, Amhis Y, An L, Anderlini L, Andreianov A, Andreotti M, Archilli F, Artamonov A, Artuso M, Arzymatov K, Aslanides E, Atzeni M, Audurier B, Bachmann S, Bachmayer M, Back JJ, Baker S, Rodriguez PB, Balagura V, Baldini W, Leite JB, Barlow RJ, Barsuk S, Barter W, Bartolini M, Baryshnikov F, Basels JM, Bassi G, Batsukh B, Battig A, Bay A, Becker M, Bedeschi F, Bediaga I, Beiter A, Belavin V, Belin S, Bellee V, Belous K, Belov I, Belyaev I, Bencivenni G, Ben-Haim E, Berezhnoy A, Bernet R, Berninghoff D, Bernstein HC, Bertella C, Bertolin A, Betancourt C, Betti F, Bezshyiko I, Bhasin S, Bhom J, Bian L, Bieker MS, Bifani S, Billoir P, Birch M, Bishop FCR, Bizzeti A, Bjørn M, Blago MP, Blake T, Blanc F, Blusk S, Bobulska D, Boelhauve JA, Garcia OB, Boettcher T, Boldyrev A, Bondar A, Bondar N, Borghi S, Borisyak M, Borsato M, Borsuk JT, Bouchiba SA, Bowcock TJV, Boyer A, Bozzi C, Bradley MJ, Braun S, Rodriguez AB, Brodski M, Brodzicka J, Gonzalo AB, Brundu D, Buonaura A, Burr C, Bursche A, Butkevich A, Butter JS, Buytaert J, Byczynski W, Cadeddu S, Cai H, Calabrese R, Calefice L, Diaz LC, Cali S, Calladine R, Calvi M, Gomez MC, Magalhaes PC, Camboni A, Campana P, Quezada AFC, Capelli S, Capriotti L, Carbone A, Carboni G, Cardinale R, Cardini A, Carli I, Carniti P, Akiba KC, Vidal AC, Casse G, Cattaneo M, Cavallero G, Celani S, Cerasoli J, Chadwick AJ, Chapman MG, Charles M, Charpentier P, Chatzikonstantinidis G, Barajas CAC, Chefdeville M, Chen C, Chen S, Chernov A, Chitic SG, Chobanova V, Cholak S, Chrzaszcz M, Chubykin A, Chulikov V, Ciambrone P, Cicala MF, Vidal XC, Ciezarek G, Clarke PEL, Clemencic M, Cliff HV, Closier J, Cobbledick JL, Coco V, Coelho JAB, Cogan J, Cogneras E, Cojocariu L, Collins P, Colombo T, Congedo L, Contu A, Cooke N, Coombs G, Corti G, Sobral CMC, Couturier B, Craik DC, Crkovská J, Torres MC, Currie R, Da Silva CL, Dall'Occo E, Dalseno J, D'Ambrosio C, Danilina A, d'Argent P, Davis A, Francisco OA, De Bruyn K, De Capua S, De Cian M, De Miranda JM, De Paula L, De Serio M, De Simone D, De Simone P, de Vries JA, Dean CT, Dean W, Decamp D, Del Buono L, Delaney B, Dembinski HP, Dendek A, Denysenko V, Derkach D, Deschamps O, Desse F, Dettori F, Dey B, Di Nezza P, Didenko S, Maronas LD, Dijkstra H, Dobishuk V, Donohoe AM, Dordei F, Dos Reis AC, Douglas L, Dovbnya A, Downes AG, Dreimanis K, Dudek MW, Dufour L, Duk V, Durante P, Durham JM, Dutta D, Dziewiecki M, Dziurda A, Dzyuba A, Easo S, Egede U, Egorychev V, Eidelman S, Eisenhardt S, Ek-In S, Eklund L, Ely S, Ene A, Epple E, Escher S, Eschle J, Esen S, Evans T, Falabella A, Fan J, Fan Y, Fang B, Farley N, Farry S, Fazzini D, Fedin P, Féo M, Declara PF, Prieto AF, Arribas JMF, Ferrari F, Lopes LF, Rodrigues FF, Sole SF, Ferrillo M, Ferro-Luzzi M, Filippov S, Fini RA, Fiorini M, Firlej M, Fischer KM, Fitzpatrick C, Fiutowski T, Fleuret F, Fontana M, Fontanelli F, Forty R, Lima VF, Sevilla MF, Frank M, Franzoso E, Frau G, Frei C, Friday DA, Fu J, Fuehring Q, Funk W, Gabriel E, Gaintseva T, Torreira AG, Galli D, Gambetta S, Gan Y, Gandelman M, Gandini P, Gao Y, Garau M, Martin LMG, Moreno PG, García Pardiñas J, Plana BG, Rosales FAG, Garrido L, Gaspar C, Geertsema RE, Gerick D, Gerken LL, Gersabeck E, Gersabeck M, Gershon T, Gerstel D, Ghez P, Gibson V, Giovannetti M, Gioventù A, Gironell PG, Giubega L, Giugliano C, Gizdov K, Gkougkousis EL, Gligorov VV, Göbel C, Golobardes E, Golubkov D, Golutvin A, Gomes A, Fernandez SG, Abrantes FG, Goncerz M, Gong G, Gorbounov P, Gorelov IV, Gotti C, Govorkova E, Grabowski JP, Diaz RG, Grammatico T, Cardoso LAG, Graugés E, Graverini E, Graziani G, Grecu A, Greeven LM, Griffith P, Grillo L, Gromov S, Cazon BRG, Gu C, Guarise M, Günther PA, Gushchin E, Guth A, Guz Y, Gys T, Hadavizadeh T, Haefeli G, Haen C, Haimberger J, Halewood-Leagas T, Hamilton PM, Han Q, Han X, Hancock TH, Hansmann-Menzemer S, Harnew N, Harrison T, Hasse C, Hatch M, He J, Hecker M, Heijhoff K, Heinicke K, Hennequin AM, Hennessy K, Henry L, Heuel J, Hicheur A, Hill D, Hilton M, Hollitt SE, Hu J, Hu J, Hu W, Huang W, Huang X, Hulsbergen W, Hunter RJ, Hushchyn M, Hutchcroft D, Hynds D, Ibis P, Idzik M, Ilin D, Ilten P, Inglessi A, Ishteev A, Ivshin K, Jacobsson R, Jakobsen S, Jans E, Jashal BK, Jawahery A, Jevtic V, Jezabek M, Jiang F, John M, Johnson D, Jones CR, Jones TP, Jost B, Jurik N, Kandybei S, Kang Y, Karacson M, Kazeev N, Keizer F, Kenzie M, Ketel T, Khanji B, Kharisova A, Kholodenko S, Kim KE, Kirn T, Kirsebom VS, Kitouni O, Klaver S, Klimaszewski K, Koliiev S, Kondybayeva A, Konoplyannikov A, Kopciewicz P, Kopecna R, Koppenburg P, Korolev M, Kostiuk I, Kot O, Kotriakhova S, Kravchenko P, Kravchuk L, Krawczyk RD, Kreps M, Kress F, Kretzschmar S, Krokovny P, Krupa W, Krzemien W, Kucewicz W, Kucharczyk M, Kudryavtsev V, Kuindersma HS, Kunde GJ, Kvaratskheliya T, Lacarrere D, Lafferty G, Lai A, Lampis A, Lancierini D, Lane JJ, Lane R, Lanfranchi G, Langenbruch C, Langer J, Lantwin O, Latham T, Lazzari F, Le Gac R, Lee SH, Lefèvre R, Leflat A, Legotin S, Leroy O, Lesiak T, Leverington B, Li H, Li L, Li P, Li Y, Li Y, Li Z, Liang X, Lin T, Lindner R, Lisovskyi V, Litvinov R, Liu G, Liu H, Liu S, Liu X, Loi A, Castro JL, Longstaff I, Lopes JH, Loustau G, Lovell GH, Lu Y, Lucchesi D, Luchuk S, Martinez ML, Lukashenko V, Luo Y, Lupato A, Luppi E, Lupton O, Lusiani A, Lyu X, Ma L, Maccolini S, Machefert F, Maciuc F, Macko V, Mackowiak P, Maddrell-Mander S, Madejczyk O, Mohan LRM, Maev O, Maevskiy A, Maisuzenko D, Majewski MW, Malde S, Malecki B, Malinin A, Maltsev T, Malygina H, Manca G, Mancinelli G, Escalero RM, Manuzzi D, Marangotto D, Maratas J, Marchand JF, Marconi U, Mariani S, Benito CM, Marinangeli M, Marino P, Marks J, Marshall PJ, Martellotti G, Martinazzoli L, Martinelli M, Santos DM, Vidal FM, Massafferri A, Materok M, Matev R, Mathad A, Mathe Z, Matiunin V, Matteuzzi C, Mattioli KR, Mauri A, Maurice E, Mauricio J, Mazurek M, McCann M, Mcconnell L, Mcgrath TH, McNab A, McNulty R, Mead JV, Meadows B, Meaux C, Meier G, Meinert N, Melnychuk D, Meloni S, Merk M, Merli A, Garcia LM, Mikhasenko M, Milanes DA, Millard E, Milovanovic M, Minard MN, Minzoni L, Mitchell SE, Mitreska B, Mitzel DS, Mödden A, Mohammed RA, Moise RD, Mombächer T, Monroy IA, Monteil S, Morandin M, Morello G, Morello MJ, Moron J, Morris AB, Morris AG, Mountain R, Mu H, Muheim F, Mukherjee M, Mulder M, Müller D, Müller K, Murphy CH, Murray D, Muzzetto P, Naik P, Nakada T, Nandakumar R, Nanut T, Nasteva I, Needham M, Neri I, Neri N, Neubert S, Neufeld N, Newcombe R, Nguyen TD, Nguyen-Mau C, Niel EM, Nieswand S, Nikitin N, Nolte NS, Nunez C, Oblakowska-Mucha A, Obraztsov V, O'Hanlon DP, Oldeman R, Onderwater CJG, Ossowska A, Goicochea JMO, Ovsiannikova T, Owen P, Oyanguren A, Pagare B, Pais PR, Pajero T, Palano A, Palutan M, Pan Y, Panshin G, Papanestis A, Pappagallo M, Pappalardo LL, Pappenheimer C, Parker W, Parkes C, Parkinson CJ, Passalacqua B, Passaleva G, Pastore A, Patel M, Patrignani C, Pawley CJ, Pearce A, Pellegrino A, Altarelli MP, Perazzini S, Pereima D, Perret P, Petridis K, Petrolini A, Petrov A, Petrucci S, Petruzzo M, Philippov A, Pica L, Piccini M, Pietrzyk B, Pietrzyk G, Pili M, Pinci D, Pisani F, Piucci A, K RP, Placinta V, Plews J, Casasus MP, Polci F, Lener MP, Poliakova M, Poluektov A, Polukhina N, Polyakov I, Polycarpo E, Pomery GJ, Ponce S, Popov D, Popov S, Poslavskii S, Prasanth K, Promberger L, Prouve C, Pugatch V, Pullen H, Punzi G, Qian W, Qin J, Quagliani R, Quintana B, Raab NV, Trejo RIR, Rachwal B, Rademacker JH, Rama M, Pernas MR, Rangel MS, Ratnikov F, Raven G, Reboud M, Redi F, Reiss F, Alepuz CR, Ren Z, Renaudin V, Ribatti R, Ricciardi S, Richards DS, Rinnert K, Robbe P, Robert A, Robertson G, Rodrigues AB, Rodrigues E, Lopez JAR, Rollings A, Roloff P, Romanovskiy V, Lamas MR, Vidal AR, Roth JD, Rotondo M, Rudolph MS, Ruf T, Vidal JR, Ryzhikov A, Ryzka J, Silva JJS, Sagidova N, Sahoo N, Saitta B, Gonzalo DS, Gras CS, Santacesaria R, Rios CS, Santimaria M, Santovetti E, Saranin D, Sarpis G, Sarpis M, Sarti A, Satriano C, Satta A, Saur M, Savrina D, Sazak H, Smead LGS, Schael S, Schellenberg M, Schiller M, Schindler H, Schmelling M, Schmidt B, Schneider O, Schopper A, Schubiger M, Schulte S, Schune MH, Schwemmer R, Sciascia B, Sciubba A, Sellam S, Semennikov A, Soares MS, Sergi A, Serra N, Sestini L, Seuthe A, Seyfert P, Shangase DM, Shapkin M, Shchemerov I, Shchutska L, Shears T, Shekhtman L, Shen Z, Shevchenko V, Shields EB, Shmanin E, Shupperd JD, Siddi BG, Coutinho RS, Simi G, Simone S, Skiba I, Skidmore N, Skwarnicki T, Slater MW, Smallwood JC, Smeaton JG, Smetkina A, Smith E, Smith M, Snoch A, Soares M, Lavra LS, Sokoloff MD, Soler FJP, Solovev A, Solovyev I, De Almeida FLS, De Paula BS, Spaan B, Norella ES, Spradlin P, Stagni F, Stahl M, Stahl S, Stefko P, Steinkamp O, Stemmle S, Stenyakin O, Stevens H, Stone S, Stramaglia ME, Straticiuc M, Strekalina D, Strokov S, Suljik F, Sun J, Sun L, Sun Y, Svihra P, Swallow PN, Swientek K, Szabelski A, Szumlak T, Szymanski M, Taneja S, Teubert F, Thomas E, Thomson KA, Tilley MJ, Tisserand V, T'Jampens S, Tobin M, Tolk S, Tomassetti L, Machado DT, Tou DY, Traill M, Tran MT, Trifonova E, Trippl C, Tuci G, Tully A, Tuning N, Ukleja A, Unverzagt DJ, Usachov A, Ustyuzhanin A, Uwer U, Vagner A, Vagnoni V, Valassi A, Valenti G, Canudas NV, van Beuzekom M, van Herwijnen E, Van Hulse CB, van Veghel M, Gomez RV, Regueiro PV, Sierra CV, Vecchi S, Velthuis JJ, Veltri M, Venkateswaran A, Veronesi M, Vesterinen M, Vieira D, Diaz MV, Viemann H, Vilasis-Cardona X, Figueras EV, Vincent P, Vitali G, Vollhardt A, Bruch DV, Vorobyev A, Vorobyev V, Voropaev N, Waldi R, Walsh J, Wang C, Wang J, Wang J, Wang J, Wang J, Wang M, Wang R, Wang Y, Wang Z, Wark HM, Watson NK, Weber SG, Websdale D, Weisser C, Westhenry BDC, White DJ, Whitehead M, Wiedner D, Wilkinson G, Wilkinson M, Williams I, Williams M, Williams MRJ, Wilson FF, Wislicki W, Witek M, Witola L, Wormser G, Wotton SA, Wu H, Wyllie K, Xiang Z, Xiao D, Xie Y, Xu A, Xu J, Xu L, Xu M, Xu Q, Xu Z, Xu Z, Yang D, Yang Y, Yang Z, Yang Z, Yao Y, Yeomans LE, Yin H, Yu J, Yuan X, Yushchenko O, Zarebski KA, Zavertyaev M, Zdybal M, Zenaiev O, Zeng M, Zhang D, Zhang L, Zhang S, Zhang Y, Zhang Y, Zhelezov A, Zheng Y, Zhou X, Zhou Y, Zhu X, Zhukov V, Zonneveld JB, Zucchelli S, Zuliani D, and Zunica G
Abstract: We present an angular analysis of the B^{+}→K^{*+}(→K_{S}^{0}π^{+})μ^{+}μ^{-} decay using 9 fb^{-1} of pp collision data collected with the LHCb experiment. For the first time, the full set of CP-averaged angular observables is measured in intervals of the dimuon invariant mass squared. Local deviations from standard model predictions are observed, similar to those in previous LHCb analyses of the isospin-partner B^{0}→K^{*0}μ^{+}μ^{-} decay. The global tension is dependent on which effective couplings are considered and on the choice of theory nuisance parameters.
Published: 2021
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11. Disseminated Infectious Disease Caused by Histoplasma capsulatum in an Adult Patient as First Manifestation of Inherited IL-12Rβ1 Deficiency.

Author: León-Lara X, Hernández-Nieto L, Zamora CV, Rodríguez-D'Cid R, Gutiérrez MEC, Espinosa-Padilla S, Bustamante J, Puel A, and Blancas-Galicia L
Subjects: Adult, Humans, Genetic Association Studies methods, Genetic Predisposition to Disease, Histoplasma, Histoplasmosis diagnosis, Histoplasmosis etiology, Receptors, Interleukin-12 deficiency
Published: 2020
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12. Protein arginine Methyltransferase 8 gene is expressed in pluripotent stem cells and its expression is modulated by the transcription factor Sox2.

Author: Solari C, Echegaray CV, Luzzani C, Cosentino MS, Waisman A, Petrone MV, Francia M, Sassone A, Canizo J, Sevlever G, Barañao L, Miriuka S, and Guberman A
Subjects: Animals, Cell Differentiation, Down-Regulation, Fibroblasts metabolism, Homeodomain Proteins metabolism, Mice, NIH 3T3 Cells, Nanog Homeobox Protein, Neurons cytology, Octamer Transcription Factor-3 metabolism, Promoter Regions, Genetic, RNA, Small Interfering metabolism, Reverse Transcriptase Polymerase Chain Reaction, Transfection, Gene Expression Regulation, Enzymologic, Pluripotent Stem Cells cytology, Protein-Arginine N-Methyltransferases metabolism, SOXB1 Transcription Factors metabolism
Abstract: Addition of methyl groups to arginine residues is catalyzed by a group of enzymes called Protein Arginine Methyltransferases (Prmt). Although Prmt1 is essential in development, its paralogue Prmt8 has been poorly studied. This gene was reported to be expressed in nervous system and involved in neurogenesis. In this work, we found that Prmt8 is expressed in mouse embryonic stem cells (ESC) and in induced pluripotent stem cells, and modulated along differentiation to neural precursor cells. We found that Prmt8 promoter activity is induced by the pluripotency transcription factors Oct4, Sox2 and Nanog. Moreover, endogenous Prmt8 mRNA levels were reduced in ESC transfected with Sox2 shRNA vector. As a whole, our results indicate that Prmt8 is expressed in pluripotent stem cells and its transcription is modulated by pluripotency transcription factors. These findings suggest that besides its known function in nervous system, Prmt8 could play a role in pluripotent stem cells., (Copyright © 2016 Elsevier Inc. All rights reserved.)
Published: 2016
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13. Search for Higgs-like bosons decaying into long-lived exotic particles.

Author: Aaij R, Adeva B, Adinolfi M, Ajaltouni Z, Akar S, Albrecht J, Alessio F, Alexander M, Ali S, Alkhazov G, Cartelle PA, Alves AA Jr, Amato S, Amerio S, Amhis Y, An L, Anderlini L, Andreassi G, Andreotti M, Andrews JE, Appleby RB, Gutierrez OA, Archilli F, d'Argent P, Romeu JA, Artamonov A, Artuso M, Aslanides E, Auriemma G, Baalouch M, Bachmann S, Back JJ, Badalov A, Baesso C, Baldini W, Barlow RJ, Barschel C, Barsuk S, Barter W, Batozskaya V, Battista V, Bay A, Beaucourt L, Beddow J, Bedeschi F, Bediaga I, Bel LJ, Bellee V, Belloli N, Belous K, Belyaev I, Ben-Haim E, Bencivenni G, Benson S, Benton J, Berezhnoy A, Bernet R, Bertolin A, Bettler MO, van Beuzekom M, Bezshyiko I, Bifani S, Billoir P, Bird T, Birnkraut A, Bitadze A, Bizzeti A, Blake T, Blanc F, Blouw J, Blusk S, Bocci V, Boettcher T, Bondar A, Bondar N, Bonivento W, Borghi S, Borisyak M, Borsato M, Bossu F, Boubdir M, Bowcock TJV, Bowen E, Bozzi C, Braun S, Britsch M, Britton T, Brodzicka J, Buchanan E, Burr C, Bursche A, Buytaert J, Cadeddu S, Calabrese R, Calvi M, Gomez MC, Campana P, Perez DC, Capriotti L, Carbone A, Carboni G, Cardinale R, Cardini A, Carniti P, Carson L, Akiba KC, Casse G, Cassina L, Garcia LC, Cattaneo M, Cauet C, Cavallero G, Cenci R, Charles M, Charpentier P, Chatzikonstantinidis G, Chefdeville M, Chen S, Cheung SF, Chobanova V, Chrzaszcz M, Vidal XC, Ciezarek G, Clarke PEL, Clemencic M, Cliff HV, Closier J, Coco V, Cogan J, Cogneras E, Cogoni V, Cojocariu L, Collazuol G, Collins P, Comerma-Montells A, Contu A, Cook A, Coquereau S, Corti G, Corvo M, Sobral CMC, Couturier B, Cowan GA, Craik DC, Crocombe A, Torres MC, Cunliffe S, Currie R, D'Ambrosio C, Dall'Occo E, Dalseno J, David PNY, Davis A, Francisco OA, De Bruyn K, De Capua S, De Cian M, De Miranda JM, De Paula L, De Simone P, Dean CT, Decamp D, Deckenhoff M, Del Buono L, Demmer M, Derkach D, Deschamps O, Dettori F, Dey B, Di Canto A, Dijkstra H, Dordei F, Dorigo M, Suárez AD, Dovbnya A, Dreimanis K, Dufour L, Dujany G, Dungs K, Durante P, Dzhelyadin R, Dziurda A, Dzyuba A, Déléage N, Easo S, Egede U, Egorychev V, Eidelman S, Eisenhardt S, Eitschberger U, Ekelhof R, Eklund L, Elsasser C, Ely S, Esen S, Evans HM, Evans T, Falabella A, Farley N, Farry S, Fay R, Ferguson D, Albor VF, Ferrari F, Rodrigues FF, Ferro-Luzzi M, Filippov S, Fiore M, Fiorini M, Firlej M, Fitzpatrick C, Fiutowski T, Fleuret F, Fohl K, Fontana M, Fontanelli F, Forshaw DC, Forty R, Frank M, Frei C, Frosini M, Fu J, Furfaro E, Färber C, Torreira AG, Galli D, Gallorini S, Gambetta S, Gandelman M, Gandini P, Gao Y, Pardiñas JG, Tico JG, Garrido L, Garsed PJ, Gascon D, Gaspar C, Gavardi L, Gazzoni G, Gerick D, Gersabeck E, Gersabeck M, Gershon T, Ghez P, Gianì S, Gibson V, Girard OG, Giubega L, Gizdov K, Gligorov VV, Golubkov D, Golutvin A, Gomes A, Gorelov IV, Gotti C, Gándara MG, Diaz RG, Cardoso LAG, Graugés E, Graverini E, Graziani G, Grecu A, Griffith P, Grillo L, Cazon BRG, Grünberg O, Gushchin E, Guz Y, Gys T, Göbel C, Hadavizadeh T, Hadjivasiliou C, Haefeli G, Haen C, Haines SC, Hall S, Hamilton B, Han X, Hansmann-Menzemer S, Harnew N, Harnew ST, Harrison J, He J, Head T, Heister A, Hennessy K, Henrard P, Henry L, Morata JAH, van Herwijnen E, Heß M, Hicheur A, Hill D, Hombach C, Hulsbergen W, Humair T, Hushchyn M, Hussain N, Hutchcroft D, Idzik M, Ilten P, Jacobsson R, Jaeger A, Jalocha J, Jans E, Jawahery A, John M, Johnson D, Jones CR, Joram C, Jost B, Jurik N, Kandybei S, Kanso W, Karacson M, Kariuki JM, Karodia S, Kecke M, Kelsey M, Kenyon IR, Kenzie M, Ketel T, Khairullin E, Khanji B, Khurewathanakul C, Kirn T, Klaver S, Klimaszewski K, Koliiev S, Kolpin M, Komarov I, Koopman RF, Koppenburg P, Kozachuk A, Kozeiha M, Kravchuk L, Kreplin K, Kreps M, Krokovny P, Kruse F, Krzemien W, Kucewicz W, Kucharczyk M, Kudryavtsev V, Kuonen AK, Kurek K, Kvaratskheliya T, Lacarrere D, Lafferty G, Lai A, Lambert D, Lanfranchi G, Langenbruch C, Langhans B, Latham T, Lazzeroni C, Gac RL, van Leerdam J, Lees JP, Leflat A, Lefrançois J, Lefèvre R, Lemaitre F, Cid EL, Leroy O, Lesiak T, Leverington B, Li Y, Likhomanenko T, Lindner R, Linn C, Lionetto F, Liu B, Liu X, Loh D, Longstaff I, Lopes JH, Lucchesi D, Martinez ML, Luo H, Lupato A, Luppi E, Lupton O, Lusiani A, Lyu X, Machefert F, Maciuc F, Maev O, Maguire K, Malde S, Malinin A, Maltsev T, Manca G, Mancinelli G, Manning P, Maratas J, Marchand JF, Marconi U, Benito CM, Marino P, Marks J, Martellotti G, Martin M, Martinelli M, Santos DM, Vidal FM, Tostes DM, Massacrier LM, Massafferri A, Matev R, Mathad A, Mathe Z, Matteuzzi C, Mauri A, Maurin B, Mazurov A, McCann M, McCarthy J, McNab A, McNulty R, Meadows B, Meier F, Meissner M, Melnychuk D, Merk M, Michielin E, Milanes DA, Minard MN, Mitzel DS, Rodriguez JM, Monroy IA, Monteil S, Morandin M, Morawski P, Mordà A, Morello MJ, Moron J, Morris AB, Mountain R, Muheim F, Mulder M, Mussini M, Müller D, Müller J, Müller K, Müller V, Naik P, Nakada T, Nandakumar R, Nandi A, Nasteva I, Needham M, Neri N, Neubert S, Neufeld N, Neuner M, Nguyen AD, Nguyen-Mau C, Niess V, Nieswand S, Niet R, Nikitin N, Nikodem T, Novoselov A, O'Hanlon DP, Oblakowska-Mucha A, Obraztsov V, Ogilvy S, Oldeman R, Onderwater CJG, Goicochea JMO, Otto A, Owen P, Oyanguren A, Palano A, Palombo F, Palutan M, Panman J, Papanestis A, Pappagallo M, Pappalardo LL, Pappenheimer C, Parker W, Parkes C, Passaleva G, Patel GD, Patel M, Patrignani C, Pearce A, Pellegrino A, Penso G, Altarelli MP, Perazzini S, Perret P, Pescatore L, Petridis K, Petrolini A, Petrov A, Petruzzo M, Olloqui EP, Pietrzyk B, Pikies M, Pinci D, Pistone A, Piucci A, Playfer S, Casasus MP, Poikela T, Polci F, Poluektov A, Polyakov I, Polycarpo E, Pomery GJ, Popov A, Popov D, Popovici B, Potterat C, Price E, Price JD, Prisciandaro J, Pritchard A, Prouve C, Pugatch V, Navarro AP, Punzi G, Qian W, Quagliani R, Rachwal B, Rademacker JH, Rama M, Pernas MR, Rangel MS, Raniuk I, Raven G, Redi F, Reichert S, Dos Reis AC, Alepuz CR, Renaudin V, Ricciardi S, Richards S, Rihl M, Rinnert K, Molina VR, Robbe P, Rodrigues AB, Rodrigues E, Lopez JAR, Perez PR, Rogozhnikov A, Roiser S, Romanovskiy V, Vidal AR, Ronayne JW, Rotondo M, Ruf T, Valls PR, Silva JJS, Sagidova N, Saitta B, Guimaraes VS, Mayordomo CS, Sedes BS, Santacesaria R, Rios CS, Santimaria M, Santovetti E, Sarti A, Satriano C, Satta A, Saunders DM, Savrina D, Schael S, Schiller M, Schindler H, Schlupp M, Schmelling M, Schmelzer T, Schmidt B, Schneider O, Schopper A, Schubiger M, Schune MH, Schwemmer R, Sciascia B, Sciubba A, Semennikov A, Sergi A, Serra N, Serrano J, Sestini L, Seyfert P, Shapkin M, Shapoval I, Shcheglov Y, Shears T, Shekhtman L, Shevchenko V, Shires A, Siddi BG, Coutinho RS, de Oliveira LS, Simi G, Sirendi M, Skidmore N, Skwarnicki T, Smith E, Smith IT, Smith J, Smith M, Snoek H, Sokoloff MD, Soler FJP, Souza D, De Paula BS, Spaan B, Spradlin P, Sridharan S, Stagni F, Stahl M, Stahl S, Stefko P, Stefkova S, Steinkamp O, Stenyakin O, Stevenson S, Stoica S, Stone S, Storaci B, Stracka S, Straticiuc M, Straumann U, Sun L, Sutcliffe W, Swientek K, Syropoulos V, Szczekowski M, Szumlak T, T'Jampens S, Tayduganov A, Tekampe T, Tellarini G, Teubert F, Thomas C, Thomas E, van Tilburg J, Tisserand V, Tobin M, Tolk S, Tomassetti L, Tonelli D, Topp-Joergensen S, Tournefier E, Tourneur S, Trabelsi K, Traill M, Tran MT, Tresch M, Trisovic A, Tsaregorodtsev A, Tsopelas P, Tully A, Tuning N, Ukleja A, Ustyuzhanin A, Uwer U, Vacca C, Vagnoni V, Valat S, Valenti G, Vallier A, Gomez RV, Regueiro PV, Vecchi S, van Veghel M, Velthuis JJ, Veltri M, Veneziano G, Venkateswaran A, Vesterinen M, Viaud B, Vieira D, Diaz MV, Vilasis-Cardona X, Volkov V, Vollhardt A, Voneki B, Voong D, Vorobyev A, Vorobyev V, Voß C, de Vries JA, Sierra CV, Waldi R, Wallace C, Wallace R, Walsh J, Wang J, Ward DR, Wark HM, Watson NK, Websdale D, Weiden A, Whitehead M, Wicht J, Wilkinson G, Wilkinson M, Williams M, Williams MP, Williams M, Williams T, Wilson FF, Wimberley J, Wishahi J, Wislicki W, Witek M, Wormser G, Wotton SA, Wraight K, Wright S, Wyllie K, Xie Y, Xing Z, Xu Z, Yang Z, Yin H, Yu J, Yuan X, Yushchenko O, Zangoli M, Zarebski KA, Zavertyaev M, Zhang L, Zhang Y, Zhang Y, Zhelezov A, Zheng Y, Zhokhov A, Zhukov V, and Zucchelli S
Abstract: A search is presented for massive long-lived particles, in the 20-60 [Formula: see text] mass range with lifetimes between 5 and 100 [Formula: see text]. The dataset used corresponds to 0.62[Formula: see text] of proton-proton collision data collected by the LHCb detector at [Formula: see text]. The particles are assumed to be pair-produced by the decay of a Higgs-like boson with mass between 80 and 140 [Formula: see text]. No excess above the background expectation is observed and limits are set on the production cross-section as a function of the long-lived particle mass and lifetime and of the Higgs-like boson mass.
Published: 2016
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14. Total phenolic compounds in milk from different species. Design of an extraction technique for quantification using the Folin-Ciocalteu method.

Author: Vázquez CV, Rojas MG, Ramírez CA, Chávez-Servín JL, García-Gasca T, Ferriz Martínez RA, García OP, Rosado JL, López-Sabater CM, Castellote AI, Montemayor HM, and de la Torre Carbot K
Subjects: Animals, Cattle, Female, Goats, Humans, Plant Extracts, Reproducibility of Results, Sheep, Milk chemistry, Molybdenum therapeutic use, Phenols analysis, Spectrophotometry methods, Tungsten Compounds therapeutic use
Abstract: Milk protects the health of newborns because it contains essential compounds that perform metabolic activities. Despite these benefits, the study of phenolic compounds in milk has been poorly explored. The objective of this study was to develop and validate a technique for extracting total phenolic compounds (TPCs) from a milk matrix and then analyzing them using the Folin-Ciocalteu method. The extraction technique was applied to goat milk and involved the addition of methanol, acetonitrile, and Carrez I and II reagents, after which protein was separated from fat through centrifugation. Subsequently, the technique was applied to goat (69.03±6.23mg GAE/L), cow (49.00±10.77mg GAE/L), sheep (167.6±58.77mg GAE/L) and human milk (82.45±12.3mg GAE/L). The technique showed an acceptable linearity (R(2)=0.9998), limit of detection (6.03mg GAE/L) and quantification (16.2mg GAE/L), repeatability (RSD=4%), reproducibility (RSD=6.8%) and recovery (>85.41%); it is thus effective and can be used in the routine analysis of milk. TPCs obtained from each type of milk indicate a high variability among species and among members of the same species., (Copyright © 2014 Elsevier Ltd. All rights reserved.)
Published: 2015
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15. Isolation of Actinobacillus pleuropneumoniae from layer hens showing clinical signs of infectious coryza.

Author: Pérez Márquez VM, Ochoa JL, Cruz CV, Alonso PS, Olmedo-Alvarez G, Vaca S, and Abascal EN
Subjects: Actinobacillus Infections microbiology, Actinobacillus pleuropneumoniae genetics, Animals, Female, Phylogeny, Specific Pathogen-Free Organisms, Actinobacillus Infections veterinary, Actinobacillus pleuropneumoniae isolation & purification, Chickens, Poultry Diseases microbiology
Abstract: Actinobacillus pleuropneumoniae is the causal agent of porcine pleuropneumonia, which is a highly contagious respiratory disease that affects swine nearly exclusively. An isolate with characteristics of some Pasteurellaceae family members (Gram-negative bacterium, pleomorphic, and NAD-dependent) was isolated from layer hens showing clinical signs of infectious coryza. This bacterium presented hemolysis on rabbit red blood cell agar plates, and PCR amplification and sequencing of its 16S rDNA gene indicated 99% identity with A. pleuropneumoniae serotypes 3 and 7. The presence of a putative apxIIA gene was also determined by PCR. A single, smooth colony of this bacterium inoculated in five, 7-day-old chicken embryos via the yolk sac route induced 100% mortality. However, inoculation into 10-wk-old, specific-pathogen-free chickens induced only light facial swelling, and reisolation of the inoculated bacterium was negative.
Published: 2014
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16. A temperature sensor based on a polymer optical fiber macro-bend.

Author: Moraleda AT, García CV, Zaballa JZ, and Arrue J
Subjects: Elastic Modulus, Equipment Design, Equipment Failure Analysis, Fiber Optic Technology instrumentation, Plastics chemistry, Refractometry instrumentation, Thermography instrumentation, Transducers
Abstract: The design and development of a plastic optical fiber (POF) macrobend temperature sensor is presented. The sensor has a linear response versus temperature at a fixed bend radius, with a sensitivity of . The sensor system used a dummy fiber-optic sensor for reference purposes having a resolution below 0.3 °C. A comprehensive experimental analysis was carried out to provide insight into the effect of different surrounding media on practical macro-bend POF sensor implementation. Experimental results are successfully compared with bend loss calculations.
Published: 2013
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17. Detection of the first gross CDC73 germline deletion in an HPT-JT syndrome family.

Author: Cascón A, Huarte-Mendicoa CV, Javier Leandro-García L, Letón R, Suela J, Santana A, Costa MB, Comino-Méndez I, Landa I, Sánchez L, Rodríguez-Antona C, Cigudosa JC, and Robledo M
Subjects: Adenoma genetics, Adenoma metabolism, Adolescent, Adult, Female, Humans, Hyperparathyroidism, Primary metabolism, Immunohistochemistry, Jaw Neoplasms metabolism, Male, Parathyroid Neoplasms genetics, Parathyroid Neoplasms metabolism, Polymerase Chain Reaction, Syndrome, Tumor Suppressor Proteins metabolism, Gene Deletion, Germ-Line Mutation, Hyperparathyroidism, Primary genetics, Jaw Neoplasms genetics, Tumor Suppressor Proteins genetics
Abstract: Hereditary primary hyperparathyroidism (HPT) may develop as a solitary endocrinopathy (FIHP) or as part of multiple endocrine neoplasia Type 1, multiple endocrine neoplasia Type 2A, or hereditary HPT-jaw tumor syndrome. Inactivating germline mutations of the tumor suppressor gene CDC73 account for 14 and 50% of all FIHP and HPT-JT patients, respectively, and have also been found in almost 20% of apparently sporadic parathyroid carcinoma patients. Although more than 60 independent germline mutations have been described, to date no rearrangement affecting the CDC73 locus has been identified. By means of multiplex-PCR we found a large germline deletion affecting the whole gene in a two-generation HPT-JT family. Subsequently array-CGH and specific PCR analysis determined that the mutation spanned ∼ 547 kb, and included four additional genes: TROVE2, GLRX2, B3GALT2, and UCHL5. Although no clear mutation-specific phenotype was found associated to the presence of the mutation, further studies are needed to assess whether the loss of the neighboring genes could modify the phenotype of carriers. There was complete absence of nuclear staining in the two HPT-JT-related tumors available. The finding of the first rearrangement affecting the CDC73 gene warrants screening for this tumor suppressor gene inactivation mechanism not only in high-risk CDC73 point mutation-negative HPT-JT families, but also in FIHP patients., (Copyright © 2011 Wiley-Liss, Inc.)
Published: 2011
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18. sLea and sLex expression in colorectal cancer: implications for tumourigenesis and disease prognosis.

Author: Portela SV, Martín CV, Romay LM, Cuevas E, Martín EG, and Briera AF
Subjects: Adenocarcinoma pathology, Adenoma metabolism, Adenoma pathology, Biomarkers, Tumor analysis, CA-19-9 Antigen, Cell Transformation, Neoplastic metabolism, Cell Transformation, Neoplastic pathology, Colorectal Neoplasms pathology, Disease-Free Survival, Humans, Immunohistochemistry, Kaplan-Meier Estimate, Neoplasm Staging, Prognosis, Sialyl Lewis X Antigen, Adenocarcinoma metabolism, Biomarkers, Tumor metabolism, Colorectal Neoplasms metabolism, Oligosaccharides biosynthesis
Abstract: The glycoconjugates expressed by cancer cells frequently contain sialylated oligosaccharide chains. Among these oligosaccharides the sialyl Lewis a (sLe(a)) and sialyl Lewis x (sLe(x)) antigens are found to be overexpressed in tumours of different origin. The current study assesses sLe(a) and sLe(x) expression in different colorectal specimens in order to establish the correlation of these biomarkers with both malignant transformation of colorectal mucosa and the progression of colorectal cancer (CRC). Healthy disease-free and inflammatory mucosa specimens showed no presence of the antigens. sLe(a) was expressed in 6.7% of the healthy tissue from CRC patients, in 20.8% of the adenomas, and in 33.3% and 42.6% of the transitional tissue and tumour tissue, respectively. sLe(x) expression was observed in 6.7% of the healthy tissue from CRC patients, in 27.0% of the adenomas, and in 25.6% and 74.8% of the transitional and the tumour tissue, respectively. The expression of the sLe(a) and sLe(x) antigens was correlated in adenomas, as well as in healthy and tumour tissue from CRC. Moreover, the high expression of sLe(x) in adenomas was correlated with a high degree of dysplasia (p=0.042). Finally, the survival analysis suggested that sLe(a) expression may be a prognostic factor for predicting disease-free survival in colorectal cancer (p=0.012).
Published: 2011
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19. Giardia intestinalis: expression of ubiquitin, glucosamine-6-phosphate and cyst wall protein genes during the encystment process.

Author: Eligio-García L, María del Pilar CV, Andrés FL, Apolinar CE, Adrián CC, and Enedina JC
Subjects: Aldose-Ketose Isomerases genetics, Giardia lamblia genetics, Giardia lamblia growth & development, Microscopy, Electron, Transmission, Microscopy, Ultraviolet, Protozoan Proteins genetics, Ubiquitin genetics, Aldose-Ketose Isomerases biosynthesis, Gene Expression, Giardia lamblia metabolism, Protozoan Proteins biosynthesis, Ubiquitin biosynthesis
Abstract: Unlabelled: We determined the relative expression of ubiquitin (ub), glucosamine-6-phosphate-isomerase (gn6pi) and cyst wall protein (cwp) genes during encystment of the Portland-1 and Portland-1R strains of Giardia intestinalis. Encystment was induced with bile for different time periods. The presence of encystment-specific vesicles (ESVs) and the relative expression of genes (log(10)ΔRn) were determined by transmission electron microscopy and real-time PCR, respectively. Our results demonstrated the gene expression and the presence of ESVs after 6h of encystment. Values of cwp2 gene expression increased by 591-fold in strain Portland-1 and 78.2-fold in strain Portland-1R at this time point compared to values at 0h, after which values gradually decreased until reaching basal values between 8 and 18h after the encystment started. Expression of gn6pi was 43.5- and 46.3-fold higher than basal values, in Portland-1 and Portland-1R, respectively. Ub gene expression was 82.25-fold higher than its basal levels at 4h, after which expression decreased gradually until reaching basal values after 16h., Conclusions: This work showed the relationship between the presence of ESVs and encystment gene expression at 6h, and resistance to albendazole does not inhibit the encystment process. The results revealed important knowledge with implications in the control of parasite dissemination for preventing parasite transmission., (Copyright © 2010 Elsevier Inc. All rights reserved.)
Published: 2011
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20. [Risk groups in differentiated thyroid carcinomas].

Author: Herránz González-Botas J, Barro CV, and Vidal JM
Subjects: Adult, Female, Humans, Incidence, Male, Middle Aged, Risk Factors, Thyroid Neoplasms epidemiology, Thyroid Neoplasms pathology
Abstract: Introduction: Well-differentiated thyroid carcinoma represents 80% of all thyroid malignant tumours, with a survival rate of over 95% at 20 years in 80% of the cases. Although its incidence is increasing, survival remains unchanged. Prognostic factor evaluation allows identifying patients at high or low risk of recurrence, selecting those who will benefit from more aggressive therapy., Material: We have reviewed the incidence of malignant thyroid neoplasm, selecting them according to three different system definitions (TNM, GAMES, MACIS), as well as by post-surgical complication rate., Results: Malignant neoplasm represents 28.8% of the thyroid-operated patients, 88% corresponding to well-differentiated carcinomas. 80% are in the low risk group, with similar numbers in all three staging system definitions. Multicentricity was found in 16%, with 50% of the lesions smaller than 2 cm. Permanent recurrent nerve palsy was 1.2% and 2.7% presented permanent postoperative hypocalcaemia., Conclusions: Risk group percentage is similar to that reported in the literature, with 80% having expected survival over 95% at 20 years. Risk factor evaluation should help to individualise treatment options, avoiding overtreatment and complications in patients that will not benefit from more aggressive therapy., (Copyright © 2010 Elsevier España, S.L. All rights reserved.)
Published: 2011
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21. Multi-centre testing and validation of current protocols for the identification of Gyrodactylus salaris (Monogenea).

Author: Shinn AP, Collins C, García-Vásquez A, Snow M, Matejusová I, Paladini G, Longshaw M, Lindenstrøm T, Stone DM, Turnbull JF, Picon-Camacho SM, Rivera CV, Duguid RA, Mo TA, Hansen H, Olstad K, Cable J, Harris PD, Kerr R, Graham D, Monaghan SJ, Yoon GH, Buchmann K, Taylor NG, Bakke TA, Raynard R, Irving S, and Bron JE
Subjects: Animals, DNA, Helminth genetics, DNA, Ribosomal genetics, Fish Diseases diagnosis, Phylogeny, Salmonidae parasitology, Trematoda classification, Trematoda genetics, Trematode Infections parasitology, Fish Diseases parasitology, Parasitology methods, Trematoda isolation & purification, Trematode Infections veterinary
Abstract: Despite routine screening requirements for the notifiable fish pathogen Gyrodactylus salaris, no standard operating procedure exists for its rapid identification and discrimination from other species of Gyrodactylus. This study assessed screening and identification efficiencies under real-world conditions for the most commonly employed identification methodologies: visual, morphometric and molecular analyses. Obtained data were used to design a best-practice processing and decision-making protocol allowing rapid specimen throughput and maximal classification accuracy. True specimen identities were established using a consensus from all three identification methods, coupled with the use of host and location information. The most experienced salmonid gyrodactylid expert correctly identified 95.1% of G. salaris specimens. Statistical methods of classification identified 66.7% of the G. salaris, demonstrating the need for much wider training. Molecular techniques (internal transcribed spacer region-restriction fragment length polymorphism (ITS-RFLP)/cytochrome c oxidase I (COI) sequencing) conducted in the diagnostic laboratory most experienced in the analysis of gyrodactylid material, identified 100% of the true G. salaris specimens. Taking into account causes of potential specimen loss, the probabilities of a specimen being accurately identified were 95%, 87% and 92% for visual, morphometric and molecular techniques, respectively, and the probabilities of correctly identifying a specimen of G. salaris by each method were 81%, 58% and 92%. Inter-analyst agreement for 189 gyrodactylids assessed by all three methods using Fleiss' Kappa suggested substantial agreement in identification between the methods. During routine surveillance periods when low numbers of specimens are analysed, we recommend that specimens be analysed using the ITS-RFLP approach followed by sequencing of specimens with a "G. salaris-like" (i.e. G. salaris, Gyrodactylus thymalli) banding pattern. During periods of suspected outbreaks, where a high volume of specimens is expected, we recommended that specimens be identified using visual identification, as the fastest processing method, to select "G. salaris-like" specimens, which are subsequently identified by molecular-based techniques., (Copyright © 2010. Published by Elsevier Ltd.)
Published: 2010
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22. Estimation of the annual production and composition of C&D Debris in Galicia (Spain).

Author: Martínez Lage I, Martínez Abella F, Herrero CV, and Ordóñez JL
Subjects: Cities, Conservation of Natural Resources, Construction Materials toxicity, Industrial Waste adverse effects, Risk Assessment, Spain, Construction Materials analysis, Environmental Pollutants analysis, Industrial Waste analysis, Waste Products analysis
Abstract: One of the key aspects that must be taken into consideration within the framework of Sustainable Construction is the management of Construction and Demolition (C&D) Debris. As for other types of waste, specific handling procedures are required to manage C&D Debris; these include reduction, reuse, recycling, and if all other possibilities fail, recovery or disposal. For public planning strategies aimed at the management of C&D Debris to be effective, it is first necessary to have specific knowledge of the type of waste materials generated in a particular region. After verifying that the methods available to determine the production and composition of C&D Debris are limited, this paper presents a procedure to ascertain the production and composition of C&D Debris, in any region. The procedure utilizes data on the surface areas of newly constructed buildings, renovations and demolitions, which are estimated from available data for recent years, as well as information on the quantity of debris generated per surface area in any type of construction site, which is obtained from recently executed constructions or from the ground plans of older buildings. The method proposed here has been applied to Galicia, one of Spain's autonomous communities, for which the quantity and composition of C&D Debris have been estimated for the horizon year 2011., (Copyright 2009 Elsevier Ltd. All rights reserved.)
Published: 2010
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23. [Moraxella catarrhalis sepsis in a 4 month-old infant with RSV+ bronchiolitis].

Author: Gomis RM, Fos II, Gomis CV, and Rubio J
Subjects: Anti-Inflammatory Agents therapeutic use, Bronchiolitis, Viral therapy, Humans, Infant, Male, Oxygen therapeutic use, Bronchiolitis, Viral virology, Moraxella catarrhalis isolation & purification, Moraxellaceae Infections complications, Respiratory Syncytial Virus Infections drug therapy, Respiratory Syncytial Virus Infections virology, Sepsis microbiology
Published: 2010
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24. Identification of iron-acquisition proteins of Avibacterium paragallinarum.

Author: Abascal EN, Guerra AC, Vázquez AS, Tenorio VR, Cruz CV, Zenteno E, Contreras GP, and Pacheco SV
Subjects: Amino Acid Sequence, Bacterial Proteins metabolism, Base Sequence, Blotting, Western, Cloning, Molecular, Computational Biology, DNA Primers genetics, Electrophoresis, Polyacrylamide Gel, Iron metabolism, Mass Spectrometry, Molecular Sequence Data, Receptors, Transferrin genetics, Repressor Proteins metabolism, Sequence Analysis, DNA, Sequence Homology, Bacterial Proteins genetics, Pasteurellaceae genetics, Receptors, Transferrin metabolism, Repressor Proteins genetics
Abstract: When Avibacterium paragallinarum reference strain 0083 (serovar A) was grown in an iron-restricted culture medium, the expression of the 60, 68 and 93 kDa outer membrane proteins increased as compared with normal media. Sera of chickens experimentally infected with Av. paragallinarum recognized these iron-restriction induced proteins, suggesting their expression in vivo. The three outer membrane proteins were identified as transferrin receptor and iron transport proteins by mass spectroscopy and a search in sequence databases. As these proteins have been reported to be regulated by the Fur protein in many bacteria, we investigated, through molecular methods, the presence of the fur gene in Av. paragallinarum. A candidate fur gene of Av. paragallinarum was amplified by polymerase chain reaction using complementary primers to conserved regions of fur gene sequences from members of the Pasteurellaceae family. The nucleotide sequence of the cloned gene, from ATG to TAA stop codon, was 453 base pairs in length and the deduced amino acid sequence showed 94% identity with Fur sequences of Actinobacillus pleuropneumoniae and Haemophilus ducreyi. The Av. paragallinarum deduced Fur protein (17.8 kDa) amino acid sequence contains the N-terminal helix-turn-helix DNA-binding domain and the two iron-binding sites in the C-terminal end, typical of other described Fur proteins. The study of iron-restriction-induced proteins and the mechanism regulating their expression could lead to an understanding of the responses of Av. paragallinarum to survive in an iron-restricted environment on host mucosal surfaces.
Published: 2009
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25. Comparative study of accuracy and clinical agreement of the CoaguChek XS portable device versus standard laboratory practice in unexperienced patients.

Author: Torreiro EG, Fernández EG, Rodríguez RM, López CV, and Núñez JB
Subjects: Acenocoumarol administration & dosage, Acenocoumarol adverse effects, Administration, Oral, Algorithms, Anticoagulants administration & dosage, Anticoagulants adverse effects, Equipment Design, Humans, Linear Models, Middle Aged, Pilot Projects, Predictive Value of Tests, Reproducibility of Results, Acenocoumarol therapeutic use, Anticoagulants therapeutic use, Blood Coagulation drug effects, Clinical Laboratory Techniques, Drug Monitoring instrumentation, International Normalized Ratio instrumentation, Reagent Strips, Self Care instrumentation
Abstract: The objective of the study was to compare the accuracy and clinical agreement of the CoaguChek XS versus the standard laboratory practice. Forty-one patients on long-term anticoagulation with acenocumarol without previous experience in self-monitoring participated to obtain 218 pairs of data. Several methods for comparative statistics were applied to assess the possible disagreements between techniques as well as a range of previously published criteria of clinical agreement and the very recently described error-grid for INR comparison that we partially modify. The mean age was 52.1 and the indications for oral anticoagulation were prosthetic valves (36.59%), atrial fibrillation (34.15%), venous thromboembolic disease (21.95%) and others (7.31%) with a target range of 2-3 INR units (63.4%) or 2.5-3.5 (36.6%). Analyzing the whole series of data, the Pearsons rho correlation coefficient for precision between methods was 0.95 and the C(b) bias correction factor for accuracy 0.99 with a minimal bias of 0.1 INR units between methods applying the Bland-Altman plot. The linear regression procedure described by Passing and Bablok showed a minimal deviation from the best-fit line and a slope of 0.90. The mean of the absolute relative differences was 7% which is in the "very good" range of agreement. No results were found in the clinically "dangerous" D zone of the error-grids with 99% of data in the clinically irrelevant and low relevant areas A and B. In this study self-management with the CoaguChek XS was clinically safe and reliable.
Published: 2009

26. Cytokine profile in collagen-induced arthritis: differences between syngeneic and allogeneic pregnancy.

Author: González DA, de León AC, Moncholi CV, Díaz BB, Pérez MC, Aguirre-Jaime A, Coello SD, and Hernández AG
Subjects: Animals, Arthritis, Experimental blood, Arthritis, Experimental pathology, Cattle, Cytokines blood, Disease Models, Animal, Female, Male, Mice, Mice, Inbred Strains blood, Pregnancy, Pregnancy, Animal blood, Arthritis, Experimental immunology, Cytokines immunology, Mice, Inbred Strains immunology, Pregnancy, Animal immunology
Abstract: Objective: To identify the differences in cytokine profile between allogeneic and syngeneic pregnancy in mice with collagen-induced arthritis (CIA)., Methods: Mice (strain B10.RIII) were injected with bovine collagen. Females were mated with males of the same strain (syngeneic pregnancy) or with males of strain B10. Q (allogeneic pregnancy). Concentrations of cytokines were measured during pregnancy and after delivery, and the onset and evolution of arthritis was followed in all female animals throughout the study period., Results: In female mice that developed CIA, cytokine concentrations were lower in allogeneic pregnancies than syngeneic pregnancies. When paired cytokine concentrations were compared in each animal during and after pregnancy, MCP-1 was lower during gestation than after delivery in both groups of pregnant mice, IL-6 was lower during gestation than after delivery only in allogeneic pregnancies, and IL-10 was lower during gestation than after delivery in allogeneic pregnancies, whereas in syngeneic pregnancies IL-10 was higher during gestation than after delivery., Conclusions: Allogeneic pregnancy was associated with less arthritis because of lower concentrations of proinflammatory cytokines (IL-6 and others), not because of an increase in the concentration of antiinflammatory cytokines (IL-10).
Published: 2008
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27. [A firm court resolution against malpractice in the treatment of obesity].

Author: Martínez CV, Mejías SM, and Esteban BM
Subjects: Humans, Spain, Malpractice legislation & jurisprudence, Obesity diet therapy
Abstract: Inappropriate dietary treatments against obesity may worsen patients' metabolic and cardiovascular risk, lead to malnutrition, facilitate the appearance in predisposed individuals of eating disorders and ultimately favor the recovery of previously lost weight. Nonetheless, incorrect therapies aimed at reducing weight, sometimes accompanied by promises of miraculous results, are still rather frequent in our country. The public criticism by Drs. Monereo and Vazquez of a concrete method used by several very popular clinics in Madrid, resulted in the director of those centers suing them for libel. In this special article, we summarize the facts, analyze the methods used in those clinics and their likely negative consequences as well as sketch the content of the verdict of one of the trials, already concluded. Its main conclusions are the following: 1) Health education and the defense of public health is a professional duty; 2) The incorrect treatment of obesity can increase the risks associated with it; 3) There is a sufficient spanish and international consensus as well as Guidelines that clearly specifies the requisites of good medical practice with regard to obesity; 4) In spite of that, there are still treatments that constitute deception and fraud of different kinds and that respond more to business motivations rather than professional ones; 5) The fact of being sued as a result of activities that make part of a responsible behavior within an institution and whose purpose is the public benefit has entailed a serious, difficult and painful situation. We consider that the relevance and interest of the verdict warrants its diffusion because it constitutes a reference for professionals and may be decisive in the struggle against bad practices in obesity treatment.
Published: 2008

28. Haemophilus paragallinarum secretes metalloproteases.

Author: Rivero-García PC, Cruz CV, Alonso PS, Vaca S, and Negrete-Abascal E
Subjects: Animals, Chickens, Culture Media, Haemophilus Infections microbiology, Haemophilus Infections veterinary, Haemophilus paragallinarum growth & development, Haemophilus paragallinarum pathogenicity, Immunoglobulin G metabolism, Metalloproteases chemistry, Poultry Diseases microbiology, Haemophilus paragallinarum enzymology, Metalloproteases metabolism
Abstract: Haemophilus paragallinarum secretes metalloproteases into different culture media lacking serum. Secreted proteins, concentrated by precipitation with 70% ammonium sulphate ((NH(4))(2)SO(4)) or methanol, displayed proteolytic activity at >100 kDa molecular mass in 10% polyacrylamide gels co-polymerized with porcine gelatin (0.1%). They were active in a broad pH range (4-9); pH 7.5 being the optimum. Protease activity was inhibited by 20 mmol EDTA/L and reactivated by calcium. The proteolytic activity was heat-stable at 40, 50, and 60 degrees C, but its activity diminished at 70 degrees C or higher. Secreted proteins partially degraded chicken immunoglobulin G (IgG) and cross-reacted with a polyclonal serum against a high molecular mass protease secreted by Actinobacillus pleuropneumoniae. Extracellular proteases could play a role in infectious coryza caused by H. paragallinarum.
Published: 2005
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29. Arthritis in mice: allogeneic pregnancy protects more than syngeneic by attenuating cellular immune response.

Author: González DA, de León AC, Moncholi CV, Córdova Jde C, and Hernández LB
Subjects: Animals, Arthritis, Experimental epidemiology, Arthritis, Experimental genetics, Female, Haplotypes, Histocompatibility Antigens Class II genetics, Incidence, Isoantigens immunology, Male, Mice, Mice, Inbred Strains, Pregnancy, Severity of Illness Index, Arthritis, Experimental immunology, Pregnancy, Animal immunology
Abstract: Objective: We tested the hypothesis that collagen induced arthritis benefits more from allogeneic pregnancy than syngeneic pregnancy., Methods: Arthritis was induced in female B10.RIII (H-2r) mice by injecting bovine type II collagen. Female mice were subsequently paired, one group with q-haplotype males (B10.Q) and the other with r-haplotype males (B10.RIII). The effect of q- and r-haplotype was measured by determining the acute phase reactant serum amyloid A (m-SAA), bovine anti-collagen type II antibodies (a-CBII), and the ratio of CD4/CD8 T lymphocytes during pregnancy and after delivery. Clinical assessment of arthritis was also performed., Results: The number of mice with maximum severity of clinical arthritis was significantly higher in the syngeneic group (11/20 vs 5/21; p = 0.04). Although we noted that in the allogeneic group the females had had a significantly higher level of a-CBII during pregnancy (p = 0.02), we also found that the ratio of CD4/CD8 was higher in the syngeneic group even if it was measured during (p = 0.04) or after gestation (p = 0.05). Taking into account all the cases of arthritis initiated in the post-gestational period there was no difference in m-SAA or in a-CBII between the 2 groups, but the ratio of CD4/CD8 was higher in the syngeneic group measured during (p = 0.03) or post gestation (p = 0.02)., Conclusion: Allogeneic pregnancy benefits more than syngeneic pregnancy by attenuating the cellular immune response, and the ratio of CD4/CD8 indicates the attenuation of cellular immunity when measured during gestation or post partum.
Published: 2004

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29 results on '"Vázquez CV"'

1. Rubella virus-associated cutaneous granulomatous disease in an immunocompetent woman.

2. Soluble ACE2 correlates with severe COVID-19 and can impair antibody responses.

3. Facile generation of surface diversity in gold nanoparticles.

4. Discriminating promiscuous from target-specific autoantibodies in COVID-19.

5. Effect of the high-level trigger for detecting long-lived particles at LHCb.

6. Observation of the Decay Λ_{b}^{0}→Λ_{c}^{+}τ^{-}ν[over ¯]_{τ}.

7. Study of Z Bosons Produced in Association with Charm in the Forward Region.

8. Nucleus-cytoskeleton communication impacts on OCT4-chromatin interactions in embryonic stem cells.

9. Observation of the Mass Difference between Neutral Charm-Meson Eigenstates.

10. Angular Analysis of the B^{+}→K^{*+}μ^{+}μ^{-} Decay.

11. Disseminated Infectious Disease Caused by Histoplasma capsulatum in an Adult Patient as First Manifestation of Inherited IL-12Rβ1 Deficiency.

12. Protein arginine Methyltransferase 8 gene is expressed in pluripotent stem cells and its expression is modulated by the transcription factor Sox2.

13. Search for Higgs-like bosons decaying into long-lived exotic particles.

14. Total phenolic compounds in milk from different species. Design of an extraction technique for quantification using the Folin-Ciocalteu method.

15. Isolation of Actinobacillus pleuropneumoniae from layer hens showing clinical signs of infectious coryza.

16. A temperature sensor based on a polymer optical fiber macro-bend.

17. Detection of the first gross CDC73 germline deletion in an HPT-JT syndrome family.

18. sLea and sLex expression in colorectal cancer: implications for tumourigenesis and disease prognosis.

19. Giardia intestinalis: expression of ubiquitin, glucosamine-6-phosphate and cyst wall protein genes during the encystment process.

20. [Risk groups in differentiated thyroid carcinomas].

21. Multi-centre testing and validation of current protocols for the identification of Gyrodactylus salaris (Monogenea).

22. Estimation of the annual production and composition of C&D Debris in Galicia (Spain).

23. [Moraxella catarrhalis sepsis in a 4 month-old infant with RSV+ bronchiolitis].

24. Identification of iron-acquisition proteins of Avibacterium paragallinarum.

25. Comparative study of accuracy and clinical agreement of the CoaguChek XS portable device versus standard laboratory practice in unexperienced patients.

26. Cytokine profile in collagen-induced arthritis: differences between syngeneic and allogeneic pregnancy.

27. [A firm court resolution against malpractice in the treatment of obesity].

28. Haemophilus paragallinarum secretes metalloproteases.

29. Arthritis in mice: allogeneic pregnancy protects more than syngeneic by attenuating cellular immune response.

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29 results on '"Vázquez CV"'

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