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7 results on '"Vázquez, Gorka"'

2. Características individuales y familiares de los adolescentes inmersos en violencia filio-parental: La agresividad física, la cohesión familiar y el conflicto interparental como variables explicativas

Author

Zuñeda, Aintzane, Llamazares, Alberto, Marañón, Daniel, and Vázquez, Gorka

Subjects
Psicología
Abstract

El objetivo del presente estudio fue analizar las diferencias en características sociodemográficas y familiares, en salud mental y agresividad de 34 adolescentes inmersos en una dinámica de violencia filio-parental (VFP) y un grupo contraste de 81 adol

Published
2016

7. Acid-sensing ion channel 2 (asic 2) and trkb interrelationships within the intervertebral disc.

Author

Cuesta A, Viña E, Cabo R, Vázquez G, Cobo R, García-Suárez O, García-Cosamalón J, and Vega JA

Subjects
Acid Sensing Ion Channels genetics, Aged, Animals, Female, Humans, Intervertebral Disc pathology, Intervertebral Disc Degeneration genetics, Intervertebral Disc Degeneration pathology, Male, Membrane Glycoproteins genetics, Mice, Mice, Knockout, Middle Aged, Protein-Tyrosine Kinases genetics, Receptor, trkB, Acid Sensing Ion Channels metabolism, Intervertebral Disc metabolism, Intervertebral Disc Degeneration metabolism, Membrane Glycoproteins metabolism, Protein-Tyrosine Kinases metabolism
Abstract

The cells of the intervertebral disc (IVD) have an unusual acidic and hyperosmotic microenvironment. They express acid-sensing ion channels (ASICs), gated by extracellular protons and mechanical forces, as well as neurotrophins and their signalling receptors. In the nervous tissues some neurotrophins regulate the expression of ASICs. The expression of ASIC2 and TrkB in human normal and degenerated IVD was assessed using quantitative-PCR, Western blot, and immunohistochemistry. Moreover, we investigated immunohistochemically the expression of ASIC2 in the IVD of TrkB-deficient mice. ASIC2 and TrkB mRNAs were found in normal human IVD and both increased significantly in degenerated IVD. ASIC2 and TrkB proteins were also found co-localized in a variable percentage of cells, being significantly higher in degenerated IVD than in controls. The murine IVD displayed ASIC2 immunoreactivity which was absent in the IVD of TrkB-deficient mice. Present results demonstrate the occurrence of ASIC2 and TrkB in the human IVD, and the increased expression of both in pathological IVD suggest their involvement in IVD degeneration. These data also suggest that TrkB-ligands might be involved in the regulation of ASIC2 expression, and therefore in mechanisms by which the IVD cells accommodate to low pH and hypertonicity.

Published
2015

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