90 results on '"V, De Robertis"'
Search Results
2. Position of the choroid plexus of the fourth ventricle in first‐ and second‐trimester fetuses: a novel approach to early diagnosis of cystic posterior fossa anomalies
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Simona Boito, T. Fanelli, Carmela Votino, Nicola Persico, G. Volpe, V. De Robertis, Claudiana Olivieri, and Paolo Volpe
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Databases, Factual ,Fourth ventricle ,Ultrasonography, Prenatal ,Diagnosis, Differential ,Fetus ,Posterior fontanelle ,Pregnancy ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Cyst ,3D ultrasound ,Central Nervous System Cysts ,Retrospective Studies ,Fourth Ventricle ,Radiological and Ultrasound Technology ,medicine.diagnostic_test ,business.industry ,Obstetrics and Gynecology ,Echogenicity ,Magnetic resonance imaging ,General Medicine ,Anatomy ,medicine.disease ,Pregnancy Trimester, First ,Early Diagnosis ,medicine.anatomical_structure ,Cranial Fossa, Posterior ,Reproductive Medicine ,Pregnancy Trimester, Second ,Coronal plane ,Choroid Plexus ,Cerebellar vermis ,Feasibility Studies ,Female ,Dandy-Walker Syndrome ,business - Abstract
OBJECTIVE To describe the sonographic appearance and position of the choroid plexus of the fourth ventricle (4V-CP) between 12 and 21 weeks' gestation in normal fetuses and in fetuses with Dandy-Walker malformation (DWM) or Blake's pouch cyst (BPC). METHODS The study population comprised 90 prospectively recruited normal singleton pregnancies and 41 pregnancies identified retrospectively from our institutional database that had a suspected posterior fossa anomaly at 12-13 weeks' gestation based on the ultrasound finding of abnormal hindbrain spaces. In all cases the final diagnosis was confirmed by prenatal and/or postnatal magnetic resonance imaging or postmortem examination. All pregnancies underwent a detailed ultrasound assessment, including a dedicated examination of the posterior fossa, at 12-13 weeks, 15-16 weeks and 20-21 weeks of gestation. Two-dimensional ultrasound images of the midsagittal and coronal views of the brain through the posterior fontanelle and three-dimensional volume datasets were obtained. Multiplanar orthogonal image correlation with volume contrast imaging was used as the reference visualization mode. Two independent operators, blinded to the fetal outcome, were asked to classify the 4V-CP as visible or not visible in both normal and abnormal cases, and to assess if the 4V-CP was positioned inside or outside the cyst in fetuses with DWM and BPC. RESULTS Of the 41 fetuses with apparently isolated cystic posterior fossa anomaly in the first trimester, eight were diagnosed with DWM, 29 were diagnosed with BPC and four were found to be normal in the second trimester. The position of the 4V-CP differed between DWM, BPC and normal cases in the first- and second-trimester ultrasound examinations. In particular, in normal fetuses, no cyst was present and, in the midsagittal and coronal planes of the posterior fossa, the 4V-CP appeared as an echogenic oval-shaped structure located inside the 4V apparently attached to the cerebellar vermis. In fetuses with DWM, the 4V-CP was not visible in the midsagittal view because it was displaced inferolaterally by the cyst. In contrast, in the coronal view of the posterior brain, the 4V-CP was visualized in all cases with DWM at 12-13 weeks, with a moderate decrease in the visualization rate at 15-16 weeks (87.5%) and at 20-21 weeks (75%). In the coronal view, the 4V-CP was classified as being outside the cyst in all DWM cases at 12-13 weeks and in 87.5% and 75% of cases at 15-16 and 20-21 weeks, respectively. In fetuses with BPC, the 4V-CP was visualized in all cases in both the midsagittal and coronal views at 12-13 weeks and in 100% and 96.6% of cases, respectively, at 15-16 weeks. In the coronal view, the 4V-CP was classified as being inside the cyst in 28 (96.6%), 27 (93.1%) and 25 (86.2%) cases at 12-13, 15-16 and 20-21 weeks, respectively. The medial segment of the 4V-CP was visualized near the inferior part of the vermis. CONCLUSIONS Our study shows that longitudinal ultrasound assessment of the 4V-CP and its temporal changes from 12 to 21 weeks is feasible. The 4V-CP is located inside the cyst, just below the vermis, in BPC and outside the cyst, inferolaterally displaced and distant from the vermian margin, in DWM, consistent with the pathogenesis of the two conditions. The position of the 4V-CP is a useful sonographic marker that can help differentiate between DWM and BPC as early as in the first trimester of pregnancy. © 2021 International Society of Ultrasound in Obstetrics and Gynecology.
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- 2021
3. Longitudinal evaluation of cerebellar vermis from 12 to 22 weeks of gestation: what's wrong with previous assessment?
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P, Volpe, V, De Robertis, G, Volpe, C, Olivieri, T, Fanelli, S, Boito, and N, Persico
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- 2022
4. Evaluation of cerebellar vermis at 12–22 weeks of gestation: why is traditional assessment incorrect?
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P. Volpe, V. De Robertis, G. Volpe, C. Olivieri, T. Fanelli, S. Boito, and N. Persico
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Reproductive Medicine ,Radiological and Ultrasound Technology ,Obstetrics and Gynecology ,Radiology, Nuclear Medicine and imaging ,General Medicine - Published
- 2023
5. EP29.10: Obstetrical referral scan: which indications?
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V. De Robertis, T. Stampalija, S. Bussolaro, G. Cali, P. Corbella, C. Formigoni, A. Iuculano, F. Nonino, L. Pasquini, F. Prefumo, A. Sciarrone, F. Taddei, N. Volpe, P. Volpe, and T. Frusca
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Reproductive Medicine ,Radiological and Ultrasound Technology ,Obstetrics and Gynecology ,Radiology, Nuclear Medicine and imaging ,General Medicine - Published
- 2022
6. VP24.10: An early different approach to diagnostic imaging of cystic posterior fossa anomalies
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Paolo Volpe, Simona Boito, A. Vigilante, G. Volpe, Nicola Persico, V. De Robertis, T. Fanelli, and Claudiana Olivieri
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medicine.medical_specialty ,Reproductive Medicine ,Radiological and Ultrasound Technology ,business.industry ,Posterior fossa ,Medical imaging ,medicine ,Obstetrics and Gynecology ,Radiology, Nuclear Medicine and imaging ,General Medicine ,Radiology ,business - Published
- 2021
7. Maternal and perinatal outcomes in high compared to low risk pregnancies complicated by severe acute respiratory syndrome coronavirus 2 infection (phase 2): the World Association of Perinatal Medicine working group on coronavirus disease 2019
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D'Antonio, F. Sen, C. Mascio, D.D. Galindo, A. Villalain, C. Herraiz, I. Arisoy, R. Ovayolu, A. Eroğlu, H. Canales, M.G. Ladella, S. Cojocaru, L. Turan, O. Turan, S. Hadar, E. Brzezinski-Sinai, N.A. Dollinger, S. Uyaniklar, O. Ocakouglu, S.R. Atak, Z. Premru-Srsen, T. Kornhauser-Cerar, L. Druškovič, M. Ples, L. Gündüz, R. Ağaçayak, E. Schvartzman, J.A. Malbran, M.N. Liberati, M. Sebastiano, F.D. Oronzi, L. Cerra, C. Buca, D. Cagnacci, A. Ramone, A. Barra, F. Carosso, A. Benedetto, C. Cosma, S. Pintiaux, A. Daelemans, C. Costa, E. Özel, A. Muhçu, M. Lopez, J.S.J. Alvarado, C. Piqueras, A.L. Oliva, D.E. Schera, G.B.L. Volpe, N. Frusca, T. Samardjiski, I. Simeonova, S. Papestiev, I.A. Hojman, J. Turkcuoglu, I. Cromi, A. Laganà, A.S. Ghezzi, F. Sirico, A. Familiari, A. Scambia, G. Sukhikh, Z.K.G.T. Gorina, K.A. de Sa, R.A.M. Vaz, M. Feuerschuette, O.H.M. Gatta, A.N.D. Youssef, A. Donna, G.D. Martinez-Varea, A. Loscalzo, G. Roselló, J.M. Stefanovic, V. Nupponen, I. Nelskylä, K. Ayala, R. Molpeceres, R.G. Vázquez, A.P. Sandri, F. Cataneo, I. Lenzi, M. Haberal, E.T. Huertas, E. Sanchez, A. Arango, P. Bermejo, A. Alcantara, M.M.G. Göynümer, G. Okuyan, E. Madalina, C. Guisan, A.C. Schulte, A.M. Esposito, V. De Robertis, V. Zdjelar, S. Lackovic, M. Mihajlovic, S. Jekova, N. Saccone, G. Aslan, M.M. Dedda, M.C.D. Chalid, M. Canache, J.E.M. Daskalakis, G. Antsaklis, P. Vega, E.C. Cueto, E. Taccaliti, C. Aykanat, Y. Özlem Genç, Ş. Froessler, B. Radulova, P.A. Morano, D. Bianchi, B. Marino, M.G.L. Meccariello, G. Rohatgi, B. Schiattarella, A. Morlando, M. Colacurci, N. Villasco, A. Biglia, N. Marques, A.L.S. Gatti, A. Luvero, D. Angioli, R. Pittaro, A. Lila, A. Zlatohlávková, B. On the behalf of the World Association of Perinatal Medicine working group on coronavirus disease 2019
- Abstract
BACKGROUND: It has still to be ascertained whether severe acute respiratory syndrome coronavirus 2 infection in pregnancy is associated with worse maternal and fetal outcomes compared to low risk gestations. OBJECTIVE: This study aimed to evaluate maternal and perinatal outcomes in high- and low-risk pregnancies complicated by severe acute respiratory syndrome coronavirus 2 infection. STUDY DESIGN: This was a multinational retrospective cohort study involving women with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 infection from 76 centers from 25 countries in Europe, the United States, South America, Asia, and Australia from April 4, 2020, to October 28, 2020. The primary outcome was a composite measure of maternal mortality and morbidity, including admission to the intensive care unit, use of mechanical ventilation, or death. The secondary outcome was a composite measure of adverse perinatal outcome, including miscarriage, fetal loss, neonatal and perinatal death, and admission to the neonatal intensive care unit. All outcomes were assessed in high- and low-risk pregnancies. Pregnancies were considered high risk in case of either preexisting chronic medical conditions in pregnancy or obstetrical disorders occurring in pregnancy. The Fisher exact test and logistic regression analysis were used to analyze the data. RESULTS: A total of 887 singleton pregnancies who tested positive for severe acute respiratory syndrome coronavirus 2 infection using reverse transcription-polymerase chain reaction of nasal and pharyngeal swab specimens were included in the study. The risk of composite adverse maternal outcomes was higher in high-risk pregnancies than in low-risk pregnancies (odds ratio, 1.52; 95% confidence interval, 1.03–2.24; P=.035). In addition, women carrying high-risk pregnancies were at higher risk of hospital admission (odds ratio, 1.48; 95% confidence interval, 1.07–2.04; P=.002), presence of severe respiratory symptoms (odds ratio, 2.13; 95% confidence interval, 0.41–3.21; P=.001), admission to the intensive care unit (odds ratio, 2.63; 95% confidence interval, 1.42–4.88), and invasive mechanical ventilation (odds ratio, 2.65; 95% confidence interval, 1.19–5.94; P=.002). When exploring perinatal outcomes, high-risk pregnancies were at high risk of adverse perinatal outcomes (odds ratio, 1.78; 95% confidence interval, 0.15–2.72; P=.009). However, such association was mainly because of the higher incidence of miscarriage in high-risk pregnancies compared with that in low-risk pregnancies (5.3% vs 1.6%, P=.008); furthermore, there was no difference in other explored outcomes between the 2 study groups. At logistic regression analysis, maternal age (odds ratio, 1.12; 95% confidence interval, 1.02–1.22; P=.023) and high-risk pregnancy (odds ratio, 4.21; 95% confidence interval, 3.90–5.11; P
- Published
- 2021
8. OP09.10: Advanced imaging of the upper lip and maxilla in the first trimester: any role for the axial plane?
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C. Labadini, Paolo Volpe, V. De Robertis, Tullio Ghi, G. Rembouskos, G. Schera, E. di Pasquo, Nicola Volpe, and Andrea Dall'Asta
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Orthodontics ,First trimester ,Transverse plane ,Reproductive Medicine ,Radiological and Ultrasound Technology ,business.industry ,Maxilla ,Upper lip ,Obstetrics and Gynecology ,Medicine ,Radiology, Nuclear Medicine and imaging ,General Medicine ,business - Published
- 2021
9. OC12.08: Conotruncal anomalies detected at early fetal echocardiography
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G. Rembouskos, V. Tamborrino, Paolo Volpe, T. Fanelli, G. Volpe, Nicola Persico, V. De Robertis, and Claudiana Olivieri
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medicine.medical_specialty ,Reproductive Medicine ,Radiological and Ultrasound Technology ,medicine.diagnostic_test ,business.industry ,Internal medicine ,Cardiology ,medicine ,Obstetrics and Gynecology ,Radiology, Nuclear Medicine and imaging ,General Medicine ,business ,Fetal echocardiography - Published
- 2021
10. VP11.06: First trimester abdominal cyst: an early sonographic sign of anorectal atresia
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G. Rembouskos, Paolo Volpe, T. Fanelli, A. Di Tonto, Nicola Volpe, V. De Robertis, A. Vigilante, and Tullio Ghi
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medicine.medical_specialty ,Radiological and Ultrasound Technology ,business.industry ,Obstetrics and Gynecology ,General Medicine ,medicine.disease ,First trimester ,Reproductive Medicine ,medicine ,Radiology, Nuclear Medicine and imaging ,Cyst ,Radiology ,business ,Anorectal atresia ,Sign (mathematics) - Published
- 2021
11. Risk of 22q11.2 deletion in fetuses with right aortic arch and without intracardiac anomalies
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G. Campobasso, V. De Robertis, Paolo Volpe, Nicola Volpe, Tiziana Frusca, Antonella Perolo, Daniela Prandstraller, Gianluigi Pilu, Tullio Ghi, and I. Cataneo
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Aortic arch ,medicine.medical_specialty ,Prenatal diagnosis ,030204 cardiovascular system & hematology ,Intracardiac injection ,03 medical and health sciences ,0302 clinical medicine ,DiGeorge syndrome ,medicine.artery ,medicine ,Radiology, Nuclear Medicine and imaging ,Pregnancy ,030219 obstetrics & reproductive medicine ,Radiological and Ultrasound Technology ,medicine.diagnostic_test ,business.industry ,Obstetrics and Gynecology ,Retrospective cohort study ,General Medicine ,medicine.disease ,Surgery ,Reproductive Medicine ,Aortic Arch Syndrome ,Radiology ,business ,Fluorescence in situ hybridization - Abstract
Objective To assess the risk of 22q11.2 deletion in fetuses with a prenatal diagnosis of right aortic arch without intracardiac anomalies (RAA-no ICA). Methods This was a retrospective study of all fetuses with RAA-no ICA diagnosed prenatally at three referral centers, between 2004 and 2014. A detailed sonographic examination was performed in each case, including visualization of the thymus and of the head and neck vessels to identify the presence of an aberrant left subclavian artery (ALSA). Karyotyping and fluorescence in situ hybridization analysis for diagnosis of 22q11.2 deletion were always offered either prenatally or postnatally. Clinical and echocardiographic examinations were performed in livebirths and a postmortem examination in cases of termination of pregnancy. Results During the study period, 85 fetuses were diagnosed prenatally with RAA-no ICA. Genetic or clinical data were not available for three cases and these were excluded from analysis. 22q11.2 deletion was found in 7/82 cases (8.5% (95% CI, 3.8–17.3%)). The thymus was small or non-visualized in all seven cases and additional abnormal sonographic findings were present in four. Conclusion 22q11.2 deletion is present in a clinically significant proportion of fetuses with a prenatal diagnosis of RAA-no ICA. In such cases, a detailed sonographic examination, with assessment of the thymus in particular, may be useful to further define the level of risk for 22q11.2 deletion. Copyright © 2015 ISUOG. Published by John Wiley & Sons Ltd.
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- 2016
12. Abnormal sonographic appearance of posterior brain at 11-14 weeks and fetal outcome
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B. Muto, T. Fanelli, G. Rembouskos, G. Volpe, Paolo Volpe, U. Passamonti, G. Campobasso, V. De Robertis, and A. Tempesta
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Fetus ,Pregnancy ,Cephalocele ,business.industry ,Neural tube ,Obstetrics and Gynecology ,Gestational age ,Retrospective cohort study ,Anatomy ,medicine.disease ,Anatomical space ,medicine.anatomical_structure ,Medicine ,Gestation ,business ,Genetics (clinical) - Abstract
Objective The aim of this retrospective study was to describe the sonographic appearance of the posterior brain anatomy in normal fetuses at 11 to 14 weeks of pregnancy and to determine the fetal outcome when one of the posterior brain anatomical space is not recognized. Methods Two groups of patients were included in the study: a control group of consecutive 311 healthy fetuses with a normal sonogram and a study group of 21 fetuses with absence of one of the three posterior brain spaces. In each fetus, images of the mid-sagittal view of the fetal face and brain at 11 to 14 weeks of gestation were obtained. Results In all fetuses with absence of one of the three posterior brain spaces, a severe anomaly, including open spina bifida, cephalocele, Dandy–Walker complex, and chromosomal aberrations, was associated. Conclusion Our study indicates that the sonographic finding characterized by the absence of one of the three posterior brain spaces seems to facilitate not only the detection of open spina bifida, as previously reported, but also of other neural tube defects, such as cephalocele, and is an important risk factor for cystic posterior brain anomalies, and/or chromosomal abnormalities. Thus it seems a poor prognostic finding for major fetal abnormalities. © 2015 John Wiley & Sons, Ltd.
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- 2015
13. Open fourth ventricle prior to 20 weeks' gestation: a benign finding?
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F. De Musso, Gianluigi Pilu, Tullio Ghi, Paolo Volpe, Elena Contro, B. Muto, and V. De Robertis
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Fetus ,Radiological and Ultrasound Technology ,business.industry ,Ultrasound ,Obstetrics and Gynecology ,Prenatal diagnosis ,General Medicine ,Anatomy ,Fourth ventricle ,medicine.disease ,Reproductive Medicine ,Gestation ,Medicine ,Radiology, Nuclear Medicine and imaging ,Cyst ,Pouch ,business ,Very high risk - Abstract
Objective To evaluate the role of the brainstem–vermis (BV) angle in the diagnosis of fetal posterior fossa abnormalities at 15–18 weeks' gestation. Methods We examined retrospectively three-dimensional (3D) ultrasound volumes acquired at 15–18 gestational weeks in fetuses with normal posterior fossa (controls) and in those with cystic posterior fossa. Whether the fourth ventricle appeared open posteriorly in axial views was noted and the BV angle was measured. A detailed follow-up was obtained in all cases. Results Of the 139 controls, 46 cases were excluded because of inadequate quality of the 3D volumes. Of the 93 remaining normal fetuses, 84 (90.3%) had a closed fourth ventricle and a BV angle 45°, significantly increased compared both with that in normal fetuses (P
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- 2014
14. OC03.04: Prospective detection and differential diagnosis of cystic posterior fossa anomalies by assessing posterior brain at 11–14 weeks
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Nicola Persico, Claudiana Olivieri, V. De Robertis, T. Fanelli, Paolo Volpe, Carmela Votino, and Gianluigi Pilu
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medicine.medical_specialty ,Reproductive Medicine ,Radiological and Ultrasound Technology ,business.industry ,medicine ,Posterior fossa ,Obstetrics and Gynecology ,Radiology, Nuclear Medicine and imaging ,General Medicine ,Radiology ,Differential diagnosis ,business - Published
- 2019
15. P20.09: Tetralogy of Fallot and malalignment ventricular septal defect detected at early echocardiography
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M. Mugavero, V. De Robertis, Paolo Volpe, T. Fanelli, G. Volpe, and G. Rembouskos
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medicine.medical_specialty ,Reproductive Medicine ,Radiological and Ultrasound Technology ,business.industry ,Internal medicine ,medicine ,Cardiology ,Obstetrics and Gynecology ,Radiology, Nuclear Medicine and imaging ,General Medicine ,business ,medicine.disease ,Tetralogy of Fallot - Published
- 2019
16. P09.08: First trimester low PAPP‐A (≤ 0.2 MoM) and risk of structural abnormalities in euploid fetuses: a prospective study
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Paolo Volpe, T. Fanelli, Claudiana Olivieri, Carmela Votino, V. De Robertis, and G. Rembouskos
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Fetus ,First trimester ,medicine.medical_specialty ,Reproductive Medicine ,Radiological and Ultrasound Technology ,business.industry ,Obstetrics ,Obstetrics and Gynecology ,Medicine ,Radiology, Nuclear Medicine and imaging ,General Medicine ,business ,Prospective cohort study - Published
- 2019
17. Risk of 22q11.2 deletion in fetuses with right aortic arch and without intracardiac anomalies
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A, Perolo, V, De Robertis, I, Cataneo, N, Volpe, G, Campobasso, T, Frusca, T, Ghi, D, Prandstraller, G, Pilu, P, Volpe, Perolo, A, De Robertis, V, Cataneo, I, Volpe, N, Campobasso, G, Frusca, T, Ghi, T, Prandstraller, D, Pilu, G, and Volpe, P
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22q11.2 deletion ,prenatal diagnosi ,Aortic Arch Syndromes ,ultrasound ,Thymus Gland ,Ultrasonography, Prenatal ,Cohort Studies ,congenital anomalie ,right aortic arch ,Pregnancy ,Karyotyping ,Prenatal Diagnosis ,DiGeorge Syndrome ,Humans ,Female ,Di George syndrome ,Ultrasonography, Doppler, Color ,In Situ Hybridization, Fluorescence ,Retrospective Studies - Abstract
To assess the risk of 22q11.2 deletion in fetuses with a prenatal diagnosis of right aortic arch without intracardiac anomalies (RAA-no ICA).This was a retrospective study of all fetuses with RAA-no ICA diagnosed prenatally at three referral centers, between 2004 and 2014. A detailed sonographic examination was performed in each case, including visualization of the thymus and of the head and neck vessels to identify the presence of an aberrant left subclavian artery (ALSA). Karyotyping and fluorescence in situ hybridization analysis for diagnosis of 22q11.2 deletion were always offered either prenatally or postnatally. Clinical and echocardiographic examinations were performed in livebirths and a postmortem examination in cases of termination of pregnancy.During the study period, 85 fetuses were diagnosed prenatally with RAA-no ICA. Genetic or clinical data were not available for three cases and these were excluded from analysis. 22q11.2 deletion was found in 7/82 cases (8.5% (95% CI, 3.8-17.3%)). The thymus was small or non-visualized in all seven cases and additional abnormal sonographic findings were present in four.22q11.2 deletion is present in a clinically significant proportion of fetuses with a prenatal diagnosis of RAA-no ICA. In such cases, a detailed sonographic examination, with assessment of the thymus in particular, may be useful to further define the level of risk for 22q11.2 deletion. Copyright © 2015 ISUOG. Published by John WileySons Ltd.
- Published
- 2016
18. Aberrant right subclavian artery (ARSA) in unselected population at first and second trimester ultrasonography
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Paolo Volpe, A. Tempesta, G. Rembouskos, G. Campobasso, V. De Robertis, Mattia Gentile, G. Volpe, and U. Passamonti
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Gynecology ,medicine.medical_specialty ,Tricuspid valve ,medicine.diagnostic_test ,business.industry ,Obstetrics and Gynecology ,Aneuploidy ,Prenatal diagnosis ,medicine.disease ,medicine.anatomical_structure ,Nuchal Translucency Measurement ,medicine.artery ,medicine ,business ,Trisomy ,Fetal echocardiography ,Genetics (clinical) ,Ductus venosus ,Subclavian artery - Abstract
Objectives To evaluate the feasibility of examining aberrant right subclavian artery (ARSA) at first and second trimester gestation, its prevalence and associations in an unselected population. Methods Right subclavian artery (RSA) was prospectively evaluated in 6617 routine patients. When ARSA was detected, fetal echocardiography was offered and fetal karyotyping was discussed. If invasive testing was performed with normal karyotype, fluorescence in situ hybridization for 22q11.2 microdeletion and additionally, in case of nuchal translucency (NT) measurement above the 99 th centile, oligo array-based comparative genomic hybridization, were offered. In all aneuploidies, NT and first trimester additional ultrasonographic (US) markers assessment (nasal bone, tricuspid valve, ductus venosus) were recorded. Results RSA assessment was feasible in 85.3% and 98% of first and second trimester examinations, respectively (overall feasibility 94%). There were detected 89 ARSA (1.42% of the feasible cases), of which 66 in the first trimester. More than 20% were associated to other abnormalities: 10 aneuploidies; 2 microdeletions (15q11.2 and 22q11.2); in the euploid fetuses, 8 associated abnormalities were observed, 4 of which were cardiac defects. In the case of 22q11.2 microdeletion, ARSA was associated only with increased NT. Conclusion Prenatal routine US assessment of the RSA is feasible by highly experienced operators in first trimester screening. There is an important association of ARSA detected in unselected population with fetal abnormalities, including aneuploidies, cardiac defects and genetic anomalies. In trisomy 21 fetuses, ARSA can be the only first trimester US marker or, when associated to increased NT, it can represent the only ‘additional’ marker. © 2012 John Wiley & Sons, Ltd. Funding sources: None Conflicts of interest: None declared
- Published
- 2012
19. OC27.03: Outcome of abdominal cysts detected at 11-14 weeks of gestation: a two-centres' experience
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Paolo Volpe, V. De Robertis, G. Rembouskos, Nicola Volpe, Andrea Dall'Asta, Tullio Ghi, and T. Fanelli
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Abdominal cysts ,medicine.medical_specialty ,Reproductive Medicine ,Radiological and Ultrasound Technology ,business.industry ,Obstetrics and Gynecology ,Medicine ,Gestation ,Radiology, Nuclear Medicine and imaging ,General Medicine ,business ,Surgery - Published
- 2018
20. Fetal interrupted aortic arch: 2D-4D echocardiography, associations and outcome
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G. Tuo, Mattia Gentile, Paolo Volpe, G. Rembouskos, G. Campobasso, V. De Robertis, Maurizio Marasini, and A. Tempesta
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Heart Defects, Congenital ,Aortic arch ,medicine.medical_specialty ,Aorta, Thoracic ,Gestational Age ,Prenatal diagnosis ,Ultrasonography, Prenatal ,Fetal Heart ,Pregnancy ,medicine.artery ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Echocardiography, Four-Dimensional ,Aorta ,Fetus ,Radiological and Ultrasound Technology ,medicine.diagnostic_test ,business.industry ,Interrupted aortic arch ,Infant, Newborn ,Pregnancy Outcome ,Obstetrics and Gynecology ,Gestational age ,General Medicine ,medicine.disease ,Surgery ,Reproductive Medicine ,Echocardiography ,Karyotyping ,Female ,Radiology ,business ,Fetal echocardiography - Abstract
Objectives To analyze fetal two-dimensional (2D) echocardiographic characteristics of interrupted aortic arch (IAA) and its different types, to explore whether the use of 4D ultrasound with B-flow imaging and spatiotemporal image correlation (STIC) can improve prenatal diagnostic accuracy, and to describe associations and outcome. Methods The study comprised IAA fetuses examined exclusively by 2D conventional echocardiography during the period from 1994 to 2003, and those identified by conventional echocardiography and examined further by 4D ultrasound with B-flow imaging and STIC during the period January 2004 to July 2008, identified among fetuses examined at two referral centers for congenital heart defects (CHD). Postnatal follow-up was available in all cases. Karyotyping and fluorescent in-situ hybridization (FISH) analysis for the DiGeorge critical region (22q11.2) were performed in all cases. Results Twenty-two cases of isolated IAA (15 Type B and seven Type A, seven and three of which, respectively, underwent B-flow imaging and STIC) were detected among 2520 cases of fetal CHD. In seven of the 15 Type B cases, a right subclavian artery arose anomalously (ARSA). 2D echocardiography failed to distinguish the type of IAA in only two cases and the ARSA in five of the seven cases. B-flow imaging and STIC successfully identified IAA types in all 10 cases examined and clearly visualized the origin and course of the ARSA, including cervical ones. FISH detected 22q11.2 microdeletion in 10 of the 15 Type B cases and an unusual association with Type A in one of the seven cases. Fetal/neonatal outcome included: eight terminations of pregnancy, one intrauterine death and four postoperative deaths in the neonatal period, and nine neonates were alive after surgery at a mean follow-up time of 58 months (range, 4 months‐13 years). Conclusion Our results confirm the feasibility of prenatal characterization of IAA and its different types based on 2D echocardiographic examination, albeit with some limitations in the thorough assessment. 4D ultrasound with B-flow imaging and STIC can apparently facilitate visualization and detailed examination of the anatomical features of the IAA types, including visualization of the neck vessels, thus supplying additional information with respect to 2D sonography. As for the known association with microdeletion 22q11.2, our data indicate that Types A and B are distinct, there being a close association only with IAA Type B. Copyright 2009 ISUOG. Published by John Wiley & Sons, Ltd.
- Published
- 2010
21. Abnormal sonographic appearance of posterior brain at 11-14 weeks and fetal outcome
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P, Volpe, B, Muto, U, Passamonti, G, Rembouskos, V, De Robertis, G, Campobasso, A, Tempesta, G, Volpe, and T, Fanelli
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Fourth Ventricle ,Pregnancy Outcome ,Chromosome Disorders ,Gestational Age ,Ultrasonography, Prenatal ,Pregnancy Trimester, First ,Spina Bifida Cystica ,Pregnancy ,Case-Control Studies ,Cisterna Magna ,Humans ,Female ,Neural Tube Defects ,Dandy-Walker Syndrome ,Brain Stem ,Encephalocele ,Retrospective Studies - Abstract
The aim of this retrospective study was to describe the sonographic appearance of the posterior brain anatomy in normal fetuses at 11 to 14 weeks of pregnancy and to determine the fetal outcome when one of the posterior brain anatomical space is not recognized.Two groups of patients were included in the study: a control group of consecutive 311 healthy fetuses with a normal sonogram and a study group of 21 fetuses with absence of one of the three posterior brain spaces. In each fetus, images of the mid-sagittal view of the fetal face and brain at 11 to 14 weeks of gestation were obtained.In all fetuses with absence of one of the three posterior brain spaces, a severe anomaly, including open spina bifida, cephalocele, Dandy-Walker complex, and chromosomal aberrations, was associated.Our study indicates that the sonographic finding characterized by the absence of one of the three posterior brain spaces seems to facilitate not only the detection of open spina bifida, as previously reported, but also of other neural tube defects, such as cephalocele, and is an important risk factor for cystic posterior brain anomalies, and/or chromosomal abnormalities. Thus it seems a poor prognostic finding for major fetal abnormalities.
- Published
- 2015
22. Characteristics, associations and outcome of partial agenesis of the corpus callosum in the fetus
- Author
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Paolo Volpe, V. De Robertis, Marco Salvatore, M. Resta, G. Caruso, Antonia Lucia Buonadonna, Mario Quarantelli, Dario Paladini, A. Stanziano, Mattia Gentile, Volpe, P, Paladini, Dario, Resta, M, Stanziano, A, Salvatore, Marco, Quarantelli, Mario, De Robertis, V, Buonadonna, Al, Caruso, G, and Gentile, M.
- Subjects
medicine.medical_specialty ,Population ,Prenatal diagnosis ,Corpus callosum ,Sensitivity and Specificity ,Ultrasonography, Prenatal ,Corpus Callosum ,Colpocephaly ,Child Development ,Pregnancy ,Humans ,Medicine ,Abnormalities, Multiple ,Radiology, Nuclear Medicine and imaging ,Abortion, Therapeutic ,Agenesis of the corpus callosum ,education ,Retrospective Studies ,Chromosome Aberrations ,education.field_of_study ,Radiological and Ultrasound Technology ,medicine.diagnostic_test ,business.industry ,Corpus Callosum Agenesis ,Patient Selection ,Infant, Newborn ,Obstetrics and Gynecology ,Magnetic resonance imaging ,General Medicine ,medicine.disease ,Echoencephalography ,Magnetic Resonance Imaging ,Surgery ,Reproductive Medicine ,Pregnancy Trimester, Second ,Female ,Radiology ,Agenesis of Corpus Callosum ,business ,Follow-Up Studies - Abstract
Objectives To report, in a population of fetuses diagnosed with partial agenesis of the corpus callosum (PACC), the sonographic characterization, incidence of cerebral, extracerebral and chromosomal anomalies, and outcome. In addition, in some of our cases a comparison was made between findings on ultrasound and fetal magnetic resonance imaging (MRI). Methods This was a retrospective study of all cases of PACC seen at two referral centers for prenatal diagnosis of congenital anomalies over a 10-year period. The following variables were assessed: indication for referral, additional cerebral and extracerebral malformations, chromosomal abnormalities, and pregnancy and fetal/neonatal outcome. Results Among 54 cases of fetal agenesis of the corpus callosum detected in the referral centers during the observation period, PACC was diagnosed at prenatal sonography in 20 cases and confirmed at pre/postnatal MRI and necropsy examinations in 19 cases (35%). These 19 constituted the study group. The diagnosis was made in the sagittal planes and in 12 cases it was made prior to 24 weeks. In most cases the indication for referral was the presence of indirect signs of callosal anomalies, such as colpocephaly. In 10 cases PACC occurred in association with other anomalies and in nine it was isolated. MRI was particularly useful for demonstrating some additional cerebral anomalies such as late sulcation, migrational pathological conditions and heterotopia. Regarding pregnancy outcome, of those diagnosed before 24 weeks which had associated anomalies, all except two were terminated. Of the nine cases with isolated PACC, all were liveborn. Follow-up was available in eight, and two of these (25%) showed evidence of significant developmental delay. In our series the outcome of isolated PACC was not better than that of complete agenesis of the corpus callosum reported in other series. Conclusions PACC can be diagnosed reliably and characterized in prenatal life. The sonographic sign present in most cases is colpocephaly. Prenatal MRI can be performed to confirm the diagnosis. It is particularly useful to demonstrate some additional cerebral anomalies such as late sulcation, migrational pathological conditions and heterotopia. The relatively poor survival rate is due to the high rate of terminations and associated major anomalies. Copyright 2006 ISUOG. Published by John Wiley & Sons, Ltd.
- Published
- 2006
23. EP04.44: Accuracy of early fetal echocardiography within 16 weeks of gestation in the diagnosis of aortic arch anomalies in a high-risk population
- Author
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G. Campobasso, V. De Robertis, Paolo Volpe, G. Volpe, T. Fanelli, and Carmela Votino
- Subjects
medicine.medical_specialty ,education.field_of_study ,Radiological and Ultrasound Technology ,medicine.diagnostic_test ,business.industry ,Population ,Aortic arch anomalies ,Obstetrics and Gynecology ,General Medicine ,Reproductive Medicine ,Internal medicine ,medicine ,Cardiology ,Gestation ,Radiology, Nuclear Medicine and imaging ,Radiology ,business ,education ,Fetal echocardiography - Published
- 2017
24. P27.02: Accuracy of early fetal echocardiography within 16 weeks of gestation in the diagnosis of outflow tracts anomalies in a high-risk population
- Author
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G. Rembouskos, A. Tempesta, Paolo Volpe, T. Fanelli, M. Panarelli, and V. De Robertis
- Subjects
medicine.medical_specialty ,education.field_of_study ,Radiological and Ultrasound Technology ,medicine.diagnostic_test ,business.industry ,Population ,Obstetrics and Gynecology ,General Medicine ,Anatomy ,Reproductive Medicine ,Internal medicine ,medicine ,Cardiology ,Gestation ,Radiology, Nuclear Medicine and imaging ,Outflow ,education ,business ,Fetal echocardiography - Published
- 2017
25. Open fourth ventricle prior to 20 weeks' gestation: a benign finding?
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E, Contro, P, Volpe, F, De Musso, B, Muto, T, Ghi, V, De Robertis, G, Pilu, E. Contro, P. Volpe, F. D. Musso, B. Muto, T. Ghi, V. D. Roberti, and G. Pilu
- Subjects
Fourth Ventricle ,Second, Prenatal Diagnosis, Retrospective Studies, Ultrasonography ,Cysts ,First, Pregnancy Trimester ,Gestational Age ,Posterior ,Ultrasonography, Prenatal ,Cranial Fossa ,ultrasonography, Female, Fourth Ventricle ,ultrasonography, Dandy-Walker Syndrome ,abnormalities/ultrasonography, Gestational Age, Humans, Imaging ,Pregnancy Trimester, First ,Imaging, Three-Dimensional ,Cranial Fossa, Posterior ,Three-Dimensional, Pregnancy, Pregnancy Trimester ,Pregnancy ,Pregnancy Trimester, Second ,Prenatal Diagnosis ,Humans ,Prenatal ,Female ,Dandy-Walker Syndrome ,abnormalities/ultrasonography, Cyst ,Retrospective Studies - Abstract
To evaluate the role of the brainstem-vermis (BV) angle in the diagnosis of fetal posterior fossa abnormalities at 15-18 weeks' gestation.We examined retrospectively three-dimensional (3D) ultrasound volumes acquired at 15-18 gestational weeks in fetuses with normal posterior fossa (controls) and in those with cystic posterior fossa. Whether the fourth ventricle appeared open posteriorly in axial views was noted and the BV angle was measured. A detailed follow-up was obtained in all cases.Of the 139 controls, 46 cases were excluded because of inadequate quality of the 3D volumes. Of the 93 remaining normal fetuses, 84 (90.3\%) had a closed fourth ventricle and a BV angle 45°, significantly increased compared both with that in normal fetuses (P
- Published
- 2014
26. Aberrant right subclavian artery (ARSA) in unselected population at first and second trimester ultrasonography
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G, Rembouskos, U, Passamonti, V, De Robertis, A, Tempesta, G, Campobasso, G, Volpe, M, Gentile, and P, Volpe
- Subjects
Heart Defects, Congenital ,Chromosomes, Human, Pair 22 ,Cardiovascular Abnormalities ,Subclavian Artery ,Gestational Age ,Aneuploidy ,Aneurysm ,Ultrasonography, Prenatal ,Congenital Abnormalities ,Pregnancy ,Karyotyping ,Prenatal Diagnosis ,Feasibility Studies ,Humans ,Female ,Prospective Studies ,Chromosome Deletion ,Deglutition Disorders ,Nuchal Translucency Measurement ,In Situ Hybridization, Fluorescence - Abstract
To evaluate the feasibility of examining aberrant right subclavian artery (ARSA) at first and second trimester gestation, its prevalence and associations in an unselected population.Right subclavian artery (RSA) was prospectively evaluated in 6617 routine patients. When ARSA was detected, fetal echocardiography was offered and fetal karyotyping was discussed. If invasive testing was performed with normal karyotype, fluorescence in situ hybridization for 22q11.2 microdeletion and additionally, in case of nuchal translucency (NT) measurement above the 99(th) centile, oligo array-based comparative genomic hybridization, were offered. In all aneuploidies, NT and first trimester additional ultrasonographic (US) markers assessment (nasal bone, tricuspid valve, ductus venosus) were recorded.RSA assessment was feasible in 85.3% and 98% of first and second trimester examinations, respectively (overall feasibility 94%). There were detected 89 ARSA (1.42% of the feasible cases), of which 66 in the first trimester. More than 20% were associated to other abnormalities: 10 aneuploidies; 2 microdeletions (15q11.2 and 22q11.2); in the euploid fetuses, 8 associated abnormalities were observed, 4 of which were cardiac defects. In the case of 22q11.2 microdeletion, ARSA was associated only with increased NT.Prenatal routine US assessment of the RSA is feasible by highly experienced operators in first trimester screening. There is an important association of ARSA detected in unselected population with fetal abnormalities, including aneuploidies, cardiac defects and genetic anomalies. In trisomy 21 fetuses, ARSA can be the only first trimester US marker or, when associated to increased NT, it can represent the only 'additional' marker.
- Published
- 2012
27. Disorders of prosencephalic development
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Paolo Volpe, G. Campobasso, V. De Robertis, and G. Rembouskos
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Pathology ,medicine.medical_specialty ,Acrocallosal Syndrome ,Gestational Age ,Corpus callosum ,Ultrasonography, Prenatal ,Diagnosis, Differential ,Prosencephalon ,Holoprosencephaly ,Pregnancy ,medicine ,Humans ,Ultrasonography, Doppler, Color ,Genetics (clinical) ,Septum pellucidum ,Corpus Callosum Agenesis ,business.industry ,Obstetrics and Gynecology ,Brain ,Anatomy ,medicine.disease ,Acrocallosal syndrome ,Prognosis ,Magnetic Resonance Imaging ,Dysplasia ,Cerebral hemisphere ,Female ,Septum Pellucidum ,business - Abstract
Abnormal ventral induction may result in disorders of formation, cleavage, and midline development of prosencephalic structures. Holoprosencephaly is a developmental field defect of impaired cleavage of prosencephalon. The most widely accepted classification of holoprosencephaly recognizes three major varieties: the alobar, semilobar and lobar types, according to the severity of the malformation. The brain malformations, characterized by the fusion of the cerebral hemisphere along the midline are commonly associated with facial anomalies. Corpus callosum agenesis and septo-optic dysplasia are disorders of prosencephalic midline development, and usually have less severe presentations but still, affected subjects may suffer from neurodevelopmental retardation, and/or endocrinologic and visual disorders. In this article we report an up-to-date of pathogenesis, prenatal sonographic findings, differential diagnosis and prognosis of the aforementioned anomalies.
- Published
- 2009
28. [Subamniotic hematoma: 3D and color Doppler imaging in the differential diagnosis of placental masses and fetal outcome]
- Author
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G, Volpe, N, Volpe, L, Fucci, G, Campobasso, V, De Robertis, L M, Schonauer, and P, Volpe
- Subjects
Adult ,Hematoma ,Placenta Diseases ,Pregnancy Outcome ,Ultrasonography, Prenatal ,Umbilical Arteries ,Vascular Neoplasms ,Umbilical Cord ,Diagnosis, Differential ,Pregnancy ,Humans ,Female ,Hemangioma ,Pregnancy Complications, Neoplastic - Abstract
The aim of this study was to evaluate the role of 3D and color Doppler (CD) imaging in prenatal diagnosis and management of placental subamniotic hematoma and to speculate about the prenatal diagnosis of the solid and cystic placental masses protruding from the fetal surface of the placenta. Five pregnancies in which a large mass was seen protruding from the fetal surface of the placenta were studied in the period between January 2006 and January 2008. 3D and color flow imaging were settled in order to monitor the sonographic features of the mass during pregnancy, to evaluate the continuity of the solid portion of the mass with the fetal placental surface and to detect the blood flow signals within the mass. This study reports the clinical outcome and the histologic findings of five cases of subamniotic hematomas detected in the course of prenatal ultrasound examinations between January 2006 and January 2008. Sonographic features of the mass protruding from the chorionic plate show a consistence typical of a solid mass, in the recent subamniotic hematoma, or a predominantly cystic mass in the chronic subamniotic hematoma. Neither adverse clinical correlations nor structural nor chromosomal fetal abnormalities were found after delivery. The joint and the continuity of the solid portion of the mass with the fetal placental surface were correctly identified by prenatal ultrasound 3D examination. The CD imaging was conclusive in order to detect the absence of blood flow within the solid part of these masses. In conclusion prenatal sonographic features in recent subamniotic hematomas include the detection of a complex structure overlying the fetal plate of the placenta next to the cord insertion, covered by a thin membrane (the amnion), containing a predominantly solid mass arising from the chorionic plate. Differential diagnosis has to be done between recent subamniotic hematoma and placental chorioangioma by the use of color flow imaging: it displays blood flow within the mass in the case of chorioangioma, and conversely demonstrates the lack of color flow signals in the hematoma. The 3D imaging is conclusive in order to identify the continuity of the solid mass with the fetal placental surface. The chronic subamniotic hematomas are predominantly cystic structures in which there is a solid component attached to the fetal surface of placenta, representing a retracted clot and/or a fibrin deposit, underlying the hematoma. The main differential diagnosis in the case of a cystic mass overlying the fetal plate of the placenta, covered by a thin membrane, during the ultrasound examination, is between a placental cyst and a large pseudocysts of the umbilical cord at the placental insertion. In the case of a pseudocyst, the transonic formation is clear and lacks of a solid mass within. The correct differential diagnosis between subamniotic hematoma and the pseudocysts of the umbilical cord is required because of the association between chromosomal anomalies and pseudocysts.
- Published
- 2008
29. Transposition of the great arteries in the fetus: assessment of the spatial relationships of the arterial trunks by four-dimensional echocardiography
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V. De Robertis, Paolo Volpe, Dario Paladini, Mariagiovanna Russo, G. Sglavo, Maurizio Marasini, M. Vassallo, Paladini, Dario, Volpe, P, Sglavo, Gabriella, Vassallo, M, De Robertis, V, Marasini, M, and Russo, Mg
- Subjects
medicine.medical_specialty ,Transposition of Great Vessels ,Risk Assessment ,Ultrasonography, Prenatal ,Pregnancy ,Internal medicine ,medicine.artery ,Image Interpretation, Computer-Assisted ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Prospective Studies ,Echocardiography, Four-Dimensional ,Aorta ,Radiological and Ultrasound Technology ,medicine.diagnostic_test ,business.industry ,Vascular disease ,Infant, Newborn ,Obstetrics and Gynecology ,General Medicine ,Anatomy ,Transposition of the great vessels ,medicine.disease ,Coronary Vessels ,Heart Valves ,Echocardiography, Doppler, Color ,medicine.anatomical_structure ,Reproductive Medicine ,Great vessels ,Great arteries ,Pregnancy Trimester, Second ,Pulmonary artery ,Cardiology ,Female ,business ,Fetal echocardiography ,Artery - Abstract
Objective Coronary arterial abnormalities can be one of the few negative prognostic indicators in transposition of the great arteries (TGA), and their occurrence is related to the type of spatial relationship of the great arteries. The main objective of this study was to assess whether the use of the reconstructed en-face view with color Doppler imaging of the four cardiac valves can demonstrate the different types of spatial relationship of the arterial trunks in fetuses with TGA, in order to derive the risk of coronary abnormalities. A secondary end-point was the evaluation of the type of coronary arterial branching pattern. Methods Twenty-three fetuses with a confirmed diagnosis of TGA underwent four-dimensional (4D) echocardiography at 19–33 gestational weeks. The en-face view of the four cardiac valves and color Doppler with high persistence were employed to assess the spatial relationships of the great arteries. In all cases, confirmation of the vessels' arrangement and coronary arterial distribution was obtained at neonatal echocardiography and/or surgery. Results The spatial relationships of the great vessels was identified correctly in 20/23 (87%) cases. The aorta was found to be located anterior to and to the right of the pulmonary trunk in 13/23 (56.5%) cases and just anterior to the pulmonary artery in 6/23 (26.1%) cases; in the remaining four (17.4%) cases, the two vessels were side by side. With respect to the association between the spatial relationship of the great arteries and the occurrence of an unusual pattern of coronary arterial branching, five of the TGA fetuses had abnormal coronary arterial distribution. Conclusions Using 4D echocardiography with color Doppler, it is possible to define the spatial relationships of the great arteries in fetuses with TGA with a high degree of accuracy. This information can be used during counseling to predict the likelihood of abnormal coronary arterial distribution. Copyright © 2008 ISUOG. Published by John Wiley & Sons, Ltd.
- Published
- 2008
30. Two- and four-dimensional echocardiography with B-flow imaging and spatiotemporal image correlation in prenatal diagnosis of isolated total anomalous pulmonary venous connection
- Author
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G. Campobasso, V. De Robertis, Mattia Gentile, S. Di Paolo, Nicola Volpe, G. Caruso, A. Stanziano, and Paolo Volpe
- Subjects
Male ,medicine.medical_specialty ,Heart disease ,Prenatal diagnosis ,Doppler echocardiography ,Ultrasonography, Prenatal ,Pregnancy ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Total anomalous pulmonary venous connection ,Vein ,Coronary sinus ,Echocardiography, Four-Dimensional ,Anomalous pulmonary venous connection ,Radiological and Ultrasound Technology ,medicine.diagnostic_test ,business.industry ,Ultrasound ,Infant, Newborn ,Pregnancy Outcome ,Obstetrics and Gynecology ,General Medicine ,medicine.disease ,Echocardiography, Doppler ,medicine.anatomical_structure ,Reproductive Medicine ,Pulmonary Veins ,Female ,Radiology ,business ,Blood Flow Velocity - Abstract
Objectives To explore whether the use of four dimensional (4D) ultrasound examination with B-flow imaging and spatiotemporal image correlation (STIC) can supply additional information with respect to two-dimensional (2D) gray-scale and color Doppler echocardiography in the prenatal characterization of isolated total anomalous pulmonary venous connection (TAPVC). Methods The study population comprised a group of three TAPVC fetuses that had been examined exclusively by conventional echocardiography, and a group of four additional cases initially identified by conventional echocardiography and examined further by 4D ultrasonography; a thorough postnatal work-up was available for all fetuses. Results At our center, isolated TAPVC was found in seven of 1040 fetuses with cardiac defects (0.67%). Anomalous drainage was supracardiac to the innominate vein in three cases, cardiac to the coronary sinus in two, and infracardiac to the portal vein in the remaining two cases. An evident asymmetry between left heart and right heart structures was observed in 4/7 cases. The confluence of the anomalous pulmonary veins (PVs) was visualized in 4/7 cases and the connecting vertical vein was identified in 3/5 cases at 2D echocardiography. 4D ultrasound imaging with B-flow imaging and STIC clearly visualized the anomalous PV confluence and the draining vertical vein in all four cases examined. Conclusion 2D and color Doppler echocardiography appears to diagnose reliably TAPVC, albeit with some limitations in thorough assessment of the pathology, depending on the anatomy of the defect, on the technical adequacy of the equipment used and on the experience of the operator. 4D ultrasound examination with Bflow imaging and STIC is apparently able to facilitate identification of the anatomical features of TAPVC, thus supplying additional information over that provided by 2D fetal sonography. Copyright 2007 ISUOG. Published by John Wiley & Sons, Ltd.
- Published
- 2007
31. OP17.08: Ductus venosus agenesis: prenatal diagnosis and fetoneonatal outcome of 35 cases
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F. Alinovi, T. Fanelli, Nicola Volpe, B. Muto, Paolo Volpe, V. De Robertis, and Tiziana Frusca
- Subjects
medicine.medical_specialty ,Reproductive Medicine ,Radiological and Ultrasound Technology ,business.industry ,Obstetrics ,Obstetrics and Gynecology ,Medicine ,Radiology, Nuclear Medicine and imaging ,Prenatal diagnosis ,General Medicine ,business ,Ductus Venosus Agenesis - Published
- 2015
32. OC01.04: The risk of 22q11.2 deletion in fetuses with a right aortic arch and a normal heart
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Paolo Volpe, Gianluigi Pilu, Tiziana Frusca, Tullio Ghi, Antonella Perolo, I. Cataneo, Nicola Volpe, G. Campobasso, and V. De Robertis
- Subjects
Aortic arch ,medicine.medical_specialty ,Fetus ,Radiological and Ultrasound Technology ,business.industry ,Obstetrics and Gynecology ,General Medicine ,Reproductive Medicine ,Internal medicine ,medicine.artery ,medicine ,Cardiology ,Radiology, Nuclear Medicine and imaging ,business ,Normal heart - Published
- 2015
33. Novel application of 4D sonography with B-flow imaging and spatio-temporal image correlation (STIC) in the assessment of the anatomy of pulmonary arteries in fetuses with pulmonary atresia and ventricular septal defect
- Author
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Paolo Volpe, Mattia Gentile, G. Caruso, S. Di Paolo, Nicola Volpe, G. Campobasso, V. De Robertis, and A. Stanziano
- Subjects
Adult ,Heart Septal Defects, Ventricular ,medicine.medical_specialty ,Arterial blood supply ,Autopsy ,Gestational Age ,Pulmonary Artery ,Ultrasonography, Prenatal ,Pregnancy ,Internal medicine ,Medicine ,Pulmonary blood flow ,Humans ,Radiology, Nuclear Medicine and imaging ,Echocardiography, Four-Dimensional ,Heart septal defect ,Fetus ,Radiological and Ultrasound Technology ,business.industry ,Pregnancy Outcome ,Obstetrics and Gynecology ,Gestational age ,Small sample ,General Medicine ,Anatomy ,medicine.disease ,Reproductive Medicine ,Pulmonary Atresia ,Cardiology ,Female ,Radiology ,business ,Pulmonary atresia - Abstract
Objectives To assess the reliability of two-dimensional gray-scale (2D) and color Doppler echocardiography in the study of the size and anatomy of the central pulmonary arteries and of the sources of pulmonary blood flow in a case series of fetuses with pulmonary atresia and ventricular septal defect (PA-VSD), and to evaluate whether the use of 4D ultrasound with B-flow imaging and spatio-temporal image correlation (STIC) can improve prenatal diagnostic accuracy. Methods The study population comprised a group of seven PA-VSD fetuses that had been examined by 2D and color Doppler echocardiography exclusively, and a group of five additional cases identified initially by conventional echocardiography and examined further by 4D ultrasound, for all of which a thorough postnatal or autopsy study of the size and anatomy of the pulmonary arteries and blood supply was available. Results 2D and color Doppler echocardiography failed to assess the anatomy of the central pulmonary arteries and the source of the pulmonary blood supply in 33% and 25% of the 12 cases, respectively. 4D ultrasound with B-flow imaging and STIC assessed successfully the anatomy of the pulmonary arteries and the source of pulmonary blood supply in all five fetuses examined. Conclusions The prognosis of PA-VSD is influenced by the anatomy of the pulmonary arteries and the sources of the pulmonary blood supply, and by coexisting extracardiac and genetic anomalies. Our findings, although limited to a small sample size, suggest that 4D echocardiography with B-flow imaging and STIC, unlike 2D ultrasound, can provide thorough visualization of very small vessels and of the arterial blood supply to the lungs of fetuses with PA-VSD. 4D ultrasound may be used in the future to improve and help to detail the diagnosis of other fetal cardiac defects. Copyright © 2006 ISUOG. Published by John Wiley & Sons, Ltd.
- Published
- 2006
34. P09.14: Sonographic characteristics of the atrial septum in fetuses with d-transposition of the great arteries needing emergency neonatal balloon atrioseptostomy
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Lucio Zannini, V. De Robertis, Paolo Volpe, Dario Paladini, Maurizio Marasini, G. Tuo, and D. Buffi
- Subjects
medicine.medical_specialty ,Fetus ,Radiological and Ultrasound Technology ,business.industry ,Obstetrics and Gynecology ,General Medicine ,Atrial septum ,Transposition (music) ,Reproductive Medicine ,Great arteries ,Internal medicine ,Cardiology ,Medicine ,Radiology, Nuclear Medicine and imaging ,Balloon atrioseptostomy ,business - Published
- 2014
35. OC02.03: Fetal interrupted aortic arch: 2D-4D echocardiography, associations and outcome
- Author
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V. De Robertis, G. Rembouskos, G. Campobasso, A. Tempesta, N. Volpe, and P. Volpe
- Subjects
Reproductive Medicine ,Radiological and Ultrasound Technology ,Obstetrics and Gynecology ,Radiology, Nuclear Medicine and imaging ,General Medicine - Published
- 2010
36. P11.06: Invasive diagnosis of fetal aneuploidies after age-alone screening and 11 + 0-13 + 6wks screening in an Italian referral fetal medicine center
- Author
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G. Campobasso, V. De Robertis, A. Tempesta, G. Rembouskos, and Paolo Volpe
- Subjects
Pediatrics ,medicine.medical_specialty ,Fetus ,Radiological and Ultrasound Technology ,Referral ,business.industry ,Obstetrics and Gynecology ,General Medicine ,Reproductive Medicine ,Medicine ,Radiology, Nuclear Medicine and imaging ,Center (algebra and category theory) ,business ,Fetal medicine - Published
- 2009
37. OP17.08: Prenatal diagnosis and outcome of isolated vascular rings
- Author
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G. Tuo, Paolo Volpe, Maurizio Marasini, G. Campobasso, V. De Robertis, and G. Rembouskos
- Subjects
medicine.medical_specialty ,Reproductive Medicine ,Radiological and Ultrasound Technology ,Obstetrics ,business.industry ,medicine ,Obstetrics and Gynecology ,Radiology, Nuclear Medicine and imaging ,Prenatal diagnosis ,General Medicine ,business ,Outcome (game theory) - Published
- 2009
38. OP06.07: Prenatal diagnosis of double aortic arch (DAA): report of 6 cases
- Author
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Mattia Gentile, Paolo Volpe, G. Campobasso, V. De Robertis, Dario Paladini, and Nicola Volpe
- Subjects
medicine.medical_specialty ,Double aortic arch ,Reproductive Medicine ,Radiological and Ultrasound Technology ,business.industry ,medicine ,Obstetrics and Gynecology ,Radiology, Nuclear Medicine and imaging ,Prenatal diagnosis ,General Medicine ,medicine.disease ,business ,Surgery - Published
- 2007
39. OP12.11: Comparison of the cardiac findings at 11 to 14 weeks' gestation with the second trimester findings
- Author
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G. Volpe, G. Rembouskos, A. Tempesta, Paolo Volpe, G. Campobasso, and V. De Robertis
- Subjects
medicine.medical_specialty ,Reproductive Medicine ,Radiological and Ultrasound Technology ,Second trimester ,Obstetrics ,business.industry ,medicine ,Obstetrics and Gynecology ,Gestation ,Radiology, Nuclear Medicine and imaging ,General Medicine ,business - Published
- 2012
40. OC11.02: Late development of the normal cerebellar vermis: is it really an obstacle to the early diagnosis of Dandy-Walker malformation?
- Author
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Paolo Volpe, Nicola Rizzo, F. De Musso, A. Tempesta, Gianluigi Pilu, Elena Contro, and V. De Robertis
- Subjects
Late development ,Reproductive Medicine ,Radiological and Ultrasound Technology ,business.industry ,Cerebellar vermis ,Obstetrics and Gynecology ,Medicine ,Radiology, Nuclear Medicine and imaging ,General Medicine ,Anatomy ,business ,Dandy-Walker malformation - Published
- 2012
41. OP07.01: First and second trimester assessment of aberrant right subclavian artery (ARSA) assessment in routine population
- Author
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Paolo Volpe, Nicola Volpe, G. Rembouskos, G. Campobasso, V. De Robertis, and A. Tempesta
- Subjects
Gynecology ,Fetus ,medicine.medical_specialty ,education.field_of_study ,Radiological and Ultrasound Technology ,medicine.diagnostic_test ,business.industry ,Obstetrics ,Incidence (epidemiology) ,Population ,Obstetrics and Gynecology ,Gestational age ,Aberrant right subclavian artery ,General Medicine ,medicine.anatomical_structure ,Reproductive Medicine ,medicine ,Amniocentesis ,Radiology, Nuclear Medicine and imaging ,business ,education ,Fetal echocardiography ,Artery - Abstract
Objectives: To define the feasibility of assessing the right subcalavian artery (RSA) in 1st and 2nd trimester ultrasonographic assessment of routine population and the association of ARSA with chromosomal, cardiac and extracardiac anomalies. Methods: RSA was prospectively evaluated since July 2009 in all routine patients booked in our fetal medicine Unit. We included 11–14 weeks assessment, pre-invasive US evaluation in patients that declined 1st trimester screening at booking and opted directly for fetal karyotyping due to maternal age ≥35 y and routine anomaly scan. All patients referred for increased NT, amniocentesis, cardiac or extracardiac abnormalities were excluded. Results: We have assessed 4068 routine patients, 3036 in the 1st and 3152 in the 2nd trimester; 2281 patients were assessed in both 1st and 2nd trimesters. RSA assessment was feasible in 2529 1st trimester exams (83%). Feasibility in the first trimester was related to the CRL/BMI ratio. In the 2nd trimester the feasibility was higher reaching 98%. The overall feasibility in our series was 91.1% (3709 feasible cases, considering both 1st and 2nd trimester evaluation). An ARSA was found in 49 fetuses (overall incidence 1.32% of the feasible cases) where 28 were detected in the 1st and 19 in the 2nd trimester. Nine of the 2nd trimester ARSA have been misdiagnosed in the 1st trimester assessment. Fetal echocardiography always confirmed the initial diagnosis, when an ARSA was detected in the screening scan (no false positive cases). Of the 49 ARSA, 39 were euploid with no other findings; the remaining 10 cases included 5 aneuploidies, 1 genetic syndrome, 1 22q11 microdeletion, 1 cardiac and 2 extracardiac abnormalities. Conclusions: The feasibility of RSA assessment in a routine population depends on gestational age and maternal BMI, with more than 80% feasible cases in the first trimester. A high rate of ARSA are associated with genetic or structural, abnormalities.
- Published
- 2011
42. P08.14: Aberrant subclavian artery in chromosomally (including 22q11 microdeletion) normal and abnormal fetuses
- Author
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A. Tempesta, G. Campobasso, V. De Robertis, Nicola Volpe, Maurizio Marasini, Paolo Volpe, and G. Rembouskos
- Subjects
Pathology ,medicine.medical_specialty ,Radiological and Ultrasound Technology ,business.industry ,Obstetrics and Gynecology ,General Medicine ,medicine.disease ,Aberrant subclavian artery ,Reproductive Medicine ,medicine ,Radiology, Nuclear Medicine and imaging ,Abnormal Fetuses ,22q11 microdeletion ,business - Published
- 2010
43. P02.11: Feasibility and duration of a complete 11 + 0 − 13 + 6 wks fetal assessment
- Author
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Paolo Volpe, A. Tempesta, G. Rembouskos, G. Campobasso, and V. De Robertis
- Subjects
Fetus ,medicine.medical_specialty ,Tricuspid valve ,Radiological and Ultrasound Technology ,business.industry ,Obstetrics and Gynecology ,Fetal position ,General Medicine ,Nasal bone ,medicine.disease ,Retroverted uterus ,Abdominal wall ,medicine.anatomical_structure ,Reproductive Medicine ,Medicine ,Radiology, Nuclear Medicine and imaging ,Radiology ,False positive rate ,business ,Ductus venosus - Abstract
Objective: The use of additional US markers during the first trimester screening permitted an increase of sensibility of the test and/or reduction of the false positive rate. The objective of this study was to analyze the feasibility and the duration of a complete structural examination of the fetus. Methods: All examinations included evaluation of nuchal translucency, nasal bone, tricuspid valve, ductus venosus, facial angle, head, brain, stomach, bladder, spine, kidneys, abdominal wall, umbilical arteries and extremities. When was not possible to conclude the examination due to the fetal position the patient was invited for a walk and re-examined later. When the visualization of the fetal structures was not satisfactory due to increased maternal MBI or retroverted uterus a TV examination was added. Facial angle was measured in 2D sections or volumes were acquired after a midsagittal section was obtained. Results: In the period May 2008 – January 2009, 838 screening test were performed. Mean CRL was 62mm. The mean duration was 16,8 (5–60) min. TV examination was needed in 12% of cases. 62% of the examinations were done in a single section while 10% were seen in 3 or more sections. The duration was increased with maternal BMI, additional TV approach and number of sections performed. The need of TV scan was associated with maternal BMI while the number of US sections depended on the fetal position. Fetal bladder and kidneys were the most frequently difficult to assess structures. Nuchal translucency, nasal bone and tricuspid valve were successfully examined in all scans. Ductus venosus waves were not satisfactory in 1% of our series. Facial angle was not feasible in 2,5% of the cases. Conclusion: A complete examination of all the fetal structures and of all US markers for abnormalities is feasible with a mean duration of 16–17min. The only factors increasing the time of the examination were maternal BMI and fetal position.
- Published
- 2009
44. OC134: Anatomy, association and outcome of prenatally detected double-outlet right ventricle
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G. Sglavo, Paolo Volpe, V. De Robertis, G. Pastore, and Dario Paladini
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medicine.medical_specialty ,Radiological and Ultrasound Technology ,business.industry ,Obstetrics and Gynecology ,General Medicine ,Anatomy ,medicine.disease ,Reproductive Medicine ,Double outlet right ventricle ,Internal medicine ,medicine ,Cardiology ,Radiology, Nuclear Medicine and imaging ,business - Published
- 2007
45. P04.20: A novel approach to enhance the identification of interruption of the aortic arch and its different types: 4D-US with B-flow imaging and spatiotemporal image correlation
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Nicola Volpe, G. Stanziano, Paolo Volpe, G. Campobasso, V. De Robertis, Dario Paladini, Mariagiovanna Russo, and Mattia Gentile
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Aortic arch ,Digital image correlation ,Radiological and Ultrasound Technology ,business.industry ,Obstetrics and Gynecology ,Pattern recognition ,General Medicine ,Identification (information) ,Reproductive Medicine ,medicine.artery ,medicine ,Radiology, Nuclear Medicine and imaging ,Artificial intelligence ,business - Published
- 2006
46. OC135: Spatial arrangement of the great arteries in TGA and other CHD with malposition of the great arteries-a fetal four-dimensional echocardiographic study
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I. Penner, G. Sglavo, V. De Robertis, Paolo Volpe, Dario Paladini, and Mattia Gentile
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medicine.medical_specialty ,Fetus ,Pediatrics ,Radiological and Ultrasound Technology ,business.industry ,Obstetrics and Gynecology ,Gestational age ,Mediastinum ,Prenatal diagnosis ,General Medicine ,Color doppler ,medicine.anatomical_structure ,Reproductive Medicine ,Great arteries ,Heart rate ,medicine ,Radiology, Nuclear Medicine and imaging ,Radiology ,Medical diagnosis ,business - Abstract
Objective: To evaluate the reproducibility and accuracy of the diagnosis of fetal heart conditions using a standardized methodology of analysis of STIC volume datasets (VD) Methods: Two fetal echocardiographers were invited to participate in the study. VD from 65 patients was selected. Most of the cases were submitted by Internet through our telemedicine program based on STIC (Tele-STIC). All the acquisitions were taken in a transverse view, beginning at the level of the four-chamber view, with an angle of acquisition necessary to include information from the upper abdomen until the upper mediastinum. There were 13 normal and 52 abnormal cases. In 37 of the cases, only one VD was included. No patient in the study had more than 2 VDs. Only 10 cases had color Doppler STIC acquisitions. Each of the examiners analyzed the VD independently and only received information regarding the gestational age. Each volume was specifically displayed in the acquisition plane as full screen. They were able to adjust the zoom, gain, and heart rate and to scroll through the A-plane. No multiplanar manipulation or rendering was allowed. Four categories were used to denote the degree of seriousness of error. Category 1 was a serious error and categories 2–4 were defined as partially correct diagnoses Results: Examiners did offline evaluations of the cases in 7 hours. There was a complete agreement between the prenatal and the postnatal diagnosis in 74% and 69% of the cases (p = 0.5598). From the normal cases, they were correct in 84%–69% (p = 0.3519) and in 71%–69% of the abnormal cases (p = 0.8303). Examiners have minor discrepancies with the postnatal diagnosis in 14–17 of the cases (p = 0.8277) and major discrepancies in 3 cases each one of them Conclusions: In experienced hands, a standardized methodology of analysis of STIC volume datasets using transverse sequential views is a reliable, reproducible and accurate tool for prenatal diagnosis, particularly for the telemedicine program.
- Published
- 2006
47. Minimally-invasive conservative techniques in management of thyroid carcinoma: a narrative review.
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de Robertis V, Achille G, Barbara F, Caivano F, Anzivino R, Guarino P, and Barbara M
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- Humans, Thyroidectomy methods, Conservative Treatment methods, Thyroid Neoplasms therapy, Thyroid Neoplasms surgery
- Published
- 2024
- Full Text
- View/download PDF
48. Electrochemotherapy as palliative care in patients with local or metastatic recurrence of head and neck cancer: review of state of the art.
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Cariti F, Caivano F, de Robertis V, Dadduzio S, Guarino P, Barbara F, Pontillo V, Russo C, Plantone F, and Barbara M
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- Humans, Neoplasm Metastasis, Head and Neck Neoplasms drug therapy, Palliative Care, Electrochemotherapy, Neoplasm Recurrence, Local drug therapy
- Published
- 2024
- Full Text
- View/download PDF
49. Clinical Practice Guidelines and Recommendations by the World Association of Perinatal Medicine and Perinatal Medicine Foundation: Reporting Suspected Findings from Fetal Central Nervous System Examination.
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De Robertis V, Sen C, Timor-Tritsch I, Volpe P, Galindo A, Khalil A, Volpe N, Gil MDM, Birnbaum R, Villalain C, and Malinger G
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- Humans, Pregnancy, Female, Central Nervous System diagnostic imaging, Central Nervous System abnormalities, Nervous System Malformations diagnostic imaging, Perinatology standards, Ultrasonography, Prenatal standards
- Abstract
These guidelines follow the mission of the World Association of Perinatal Medicine, in collaboration with the Perinatal Medicine Foundation, which brings together groups and individuals worldwide, with the aim to improve prenatal detection of central nervous system anomalies and the appropriate referral of pregnancies with suspected fetal anomalies. In addition, this document provides further guidance for healthcare practitioners with the goal of standardizing the description of ultrasonographic abnormal findings., (© 2024 S. Karger AG, Basel.)
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- 2024
- Full Text
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50. Impact of choroid plexus size in prenatal diagnosis of normal and abnormal closure of fourth ventricle.
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Volpe P, De Robertis V, Fanelli T, Volpe G, Olivieri C, Boito S, and Persico N
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- Female, Pregnancy, Humans, Infant, Retrospective Studies, Reproducibility of Results, Ultrasonography, Prenatal methods, Prenatal Diagnosis, Gestational Age, Magnetic Resonance Imaging methods, Fourth Ventricle diagnostic imaging, Choroid Plexus diagnostic imaging
- Abstract
Objective: To assess the role of the choroid plexus (CP) of the fourth ventricle (4V) in fetuses with an open 4V and a normal cerebellar vermis., Methods: Two groups of patients were recruited in two fetal medicine referral centers. The prospectively collected control group included singleton pregnancies with a normal sonographic examination after first-trimester combined screening for chromosomal abnormalities and normal outcome, recruited in the period between 2019 and 2022. The study group was selected retrospectively by searching our databases to identify all cases with an isolated open 4V and normal anatomy and size of the cerebellar vermis. The inclusion criteria of the study group were: (1) gestational age between 20 and 22 weeks; (2) a brainstem-vermis angle ≥ 18° in the midsagittal plane with an otherwise normal cerebellum and vermis; (3) 4V-CP visible and seen separately from the vermis; (4) absence of other intra- and extracranial anomalies; and (5) available prenatal and/or postnatal magnetic resonance imaging (MRI) data., Results: In 169 cases of the control group, the 4V-CP was seen separately from the cerebellar vermis and was noticed to progressively fill the space caudal to the 4V, between the vermis and brainstem. From 12 to 22 weeks, the surface areas of the vermis and medial portion of the 4V-CP increased progressively with advancing gestation (P < 0.0001). Intra- and interobserver correlation analysis showed good reproducibility for the measurements. Among the cases with an open 4V and a normal vermis, it was retrospectively feasible to visualize the 4V-CP separately from the inferior part of the vermis in 41 fetuses. In five of these cases, the open 4V was due to a small CP. In all 41 fetuses, the diagnosis on MRI was isolated upward rotation of the cerebellar vermis, and no additional anomaly was found., Conclusions: Closure of the 4V is dependent on the 4V-CP and not only the cerebellar vermis. In fact, a small CP may represent another cause of an open 4V. Therefore, separate visualization of the 4V-CP and cerebellar vermis is crucial to improve discrimination between the different causes of an open 4V at the anomaly scan and its clinical implications. © 2023 International Society of Ultrasound in Obstetrics and Gynecology., (© 2023 International Society of Ultrasound in Obstetrics and Gynecology.)
- Published
- 2023
- Full Text
- View/download PDF
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