15 results on '"Uysal, Melis"'
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2. The utility of fluorescence imaging in detecting primary and metastatic small bowel carcinoid tumors
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Sarioglu, Ali Gunduz, Akgun, Ege, Uysal, Melis, Osman, Mohammed, and Berber, Eren
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- 2024
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3. Effects of thiamethoxam on brain structure of Bombus terrestris (Hymenoptera: Apidae) workers
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Çakıcı, Özlem, Uysal, Melis, Demirözer, Ozan, and Gösterit, Ayhan
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- 2023
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4. Intensive locoregional therapy before Liver Transplantation for colorectal cancer liver metastasis: A novel pre-transplant protocol
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Wehrle, Chase J., primary, Fujiki, Masato, additional, Schlegel, Andrea, additional, Uysal, Melis, additional, Anastasia Sobotka, RN, additional, Whitsett Linganna, Maureen, additional, Modaresi Esfeh, Jamak, additional, Kamath, Suneel, additional, Khalil, Mazhar, additional, Pita, Alejandro, additional, Kim, Jae-Keun, additional, Kwon, David CH, additional, Miller, Charles, additional, Hashimoto, Koji, additional, and Aucejo, Federico, additional
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- 2024
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5. Emerging and Clinically Accepted Biomarkers for Hepatocellular Carcinoma
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Fares, Sami, primary, Wehrle, Chase J., additional, Hong, Hanna, additional, Sun, Keyue, additional, Jiao, Chunbao, additional, Zhang, Mingyi, additional, Gross, Abby, additional, Allkushi, Erlind, additional, Uysal, Melis, additional, Kamath, Suneel, additional, Ma, Wen Wee, additional, Modaresi Esfeh, Jamak, additional, Linganna, Maureen Whitsett, additional, Khalil, Mazhar, additional, Pita, Alejandro, additional, Kim, Jaekeun, additional, Walsh, R. Matthew, additional, Miller, Charles, additional, Hashimoto, Koji, additional, Schlegel, Andrea, additional, Kwon, David Choon Hyuck, additional, and Aucejo, Federico, additional
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- 2024
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6. Comparison of Perioperative Outcomes in Patients with Graves’ Disease Undergoing Total Thyroidectomy with or without Near Infrared Auto-Fluorescence Imaging
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Uysal, Melis, primary, Akgun, Ege, additional, Sarioglu, Ali Gunduz, additional, and Berber, Eren, additional
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- 2023
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7. The utility of fluorescence imaging in detecting primary and metastatic small bowel carcinoid tumors
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Sarioglu, Ali Gunduz, primary, Akgun, Ege, additional, Uysal, Melis, additional, Osman, Mohammed, additional, and Berber, Eren, additional
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- 2023
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8. Effects of thiamethoxam on brain structure of Bombus terrestris (Hymenoptera: Apidae) workers
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Çakici, Özlem, primary, Uysal, Melis, additional, Demirözer, Ozan, additional, and Gösterit, Ayhan, additional
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- 2023
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9. Comparison of Perioperative Outcomes in Patients with Graves' Disease Undergoing Total Thyroidectomy With or Without Near Infrared Autofluorescence Imaging.
- Author
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Uysal, Melis, Akgun, Ege, Sarioglu, Ali Gunduz, and Berber, Eren
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THYROIDECTOMY , *INFRARED imaging , *PARATHYROID glands , *MANN Whitney U Test , *TREATMENT effectiveness - Abstract
Background: The impact of near-infrared autofluorescence (NIRAF) imaging on postthyroidectomy hypocalcemia is controversial. As patients with Graves' disease are at increased risk, our aim was to compare postoperative parathyroid function in these patients undergoing total thyroidectomy (TT) with or without NIRAF imaging. Methods: This was a retrospective "before and after" study, comparing outcomes of patients who underwent TT without or with NIRAF imaging at a single center. Primary outcome was the incidence of temporary hypocalcemia and secondary outcomes, rates of incidental parathyroidectomy on final specimens and permanent hypocalcemia. Analyses were performed using Mann-Whitney U and chi-Square tests. Continuous data are expressed as median (interquartile range). Results: There were 85 patients in NIRAF and 100 patients in non-NIRAF group. Groups were comparable regarding age, gender, body-mass index, and thyroid weight. Number of parathyroid glands identified intraoperatively was 3 in both groups (p = 0.47). Intraoperative parathyroid implantation rate was 16.5% in NIRAF and 6% in non-NIRAF group (p = 0.02). Incidental parathyroidectomy rate on final pathology was 12.9% in NIRAF and 32% in non-NIRAF group (p = 0.002). The rates of temporary (11.7% vs. 16%) and permanent hypocalcemia (2.4% vs. 2%) were similar between the two groups, respectively (p = 0.66). Conclusion: To our knowledge, this is the first comparative study investigating the impact of NIRAF on postoperative parathyroid function after thyroidectomy for Graves' disease. The rate of incidental parathyroidectomy on final pathology was lower with use of NIRAF, without an impact on temporary or permanent hypocalcemia rates compared to conventional technique. [ABSTRACT FROM AUTHOR]
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- 2024
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10. Yeşil dokunun yapma çevre ile bütünleşmesi
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Uysal, Melis, Velioğlu, Şerif Selim, Peyzaj Mimarlığı Ana Bilim Dalı, Peyzaj Mimarlığı, and Lanscape Architecture
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Green areas Built environment Spatial design ,Urban green areas ,Peyzaj Mimarlığı ,Yeşil doku Yapma çevre Mekansal tasarım ,Landscape Architecture - Abstract
Tez (Yüksek Lisans) -- İstanbul Teknik Üniversitesi, Fen Bilimleri Enstitüsü, 2014, Thesis (M.Sc.) -- İstanbul Technical University, Institute of Science and Technology, 2014, Mekansal çevrenin yeşil dokuyla ilişkili olduğu unsurlara bağlı olarak yeşil doku ile yerleşim dokularını bütünleştiren yaklaşımlar gelişmektedir. Antik çağlardan itibaren gelişen geleneksel yerleşim dokularını incelediğimizde, iklim, arazi yapısı, savunma, barınma gibi hem doğal unsurların hem de toplumsal gerekliliklerin mekansal karaktere yansıdığı görülmektedir. Özellikle sanayi devriminden itibaren değişen kent yaşantısının etkisi, çevre sorunlarının da belirgin hale gelmesine neden olmuş ve beraberinde doğal değerlere duyarlılığın da artması yeşil dokuyla bütünleştirici yaklaşımların en azından kavramsal anlamda öne çıkmasını sağlamıştır. Bu çerçevede; doğa ile yapma çevre arasındaki bağı önceki dönemlerde yaşamsal gerekliliklerin kurması söz konusu iken, sanayileşmeden sonra değişen çevre koşullarına uyum ve çevre sorunlarını giderme amacının bu bağı biçimlendirdiği anlaşılmaktadır. Literatür araştırmasına bağlı olarak, yeşil dokunun yapma çevreyle bütünleşmesinin birbiriyle ilişkili başlıca 3 tasarım ölçeğinde değerlendirilmesi gerektiği savını ortaya koyarak, çalışmamız bu kavramsal çerçeve içinde ilerlemiştir. Bunlar; - Kent planlama ölçeği - Kentsel tasarım ve yapı grubu ölçeği - Tek yapı ölçeğidir. Kent planlama ölçeğinde yeşil dokunun yapma çevreyle bütünleşmesi, kentin yeşil alan omurgasını biçimlendirerek ekolojik dengeyi kuran ve fiziksel çevre biçimlendirmesiyle çevre karakterini de etkileyen üst kararları alabilmeyi içerir. Kentsel tasarım ölçeğinde yeşil doku ile yapma çevrenin bütünleşmesi, birbiriyle bağlantılı mekan dizisinin doğal değerlere duyarlılık gözetilerek akıcı bir yeşil doku bütünlüğüne sahip olmasını kapsar. Yapı grubunun parçalı yapısı arasında kalan mekansal çevrede, dış mekan yaşantısının etkisiyle kent ile bağlantı kurabilmeyi içerir. Mimari ölçekte yapma çevrenin yeşil doku barındırması, yapının avlular oluşturacak şekilde biçimlenmesi, yeşil dokuyu kesintiye uğratmaksızın arazi formuyla bağlanarak yapının yeraltına gömülmesi, çeşitli uygulama tekniklerinden faydalanarak bitkisel unsurların yapı bileşeni olarak bina kabuğunda çatı ve cephe bitkilendirmesi olarak yer almasıdır. Yeşil doku ile mekansal çevrenin bütünleşmesini bütüncül bir yaklaşıma dönüştürmeyi amaçlayan bu tez çalışması 4 bölümden oluşmaktadır: 1. Bölümde; temel sorun ortaya koyulmuş ve çalışmanın kavramsal çerçevesi belirtilmiştir. 2. Bölümde; doğal kaynakların çevre politikalarına göre korunması irdelenmiştir. 3. Bölümde; yeşil doku ile yapma çevre bütünleşmesinin birbiri ile ilişkili başlıca 3 tasarım ölçeğinde değerlendirilmesi gerektiğinin irdelenmesi yer almaktadır. Bunlar; kent planlama ölçeği, kentsel tasarım ve yapı grubu ölçeği ve tek yapı ölçeğidir. 4. Bölüm ise; tezin sonuçlarını içermektedir, Green areas and built environment integrate according to the each part of spatial environment that are connected with green areas. This thesis work aims to transform the green area and spatial environment integration into a unifying approach. Before extracting the spatial environment into its dimensions and elements connected with green areas, a definition of a relationship between green areas and built environment is required. When we examine the traditional settlements from the beginning of the earliest time of urban life formation, we observe that within the context of the natural elements such as climate and topography, as well as diverse social requirements such as defense and shelter form the urban pattern. Likewise, when we examine the period from the industrial revolution began in 18th century to the present, we observe that the urban life has changed. Therefore, along with the increasing environmental problems the sensitivity to the nature has grown. Consequently, the integrative approach for the settlements and green areas come forward at least in the theoretical area. Accordingly, in the previous periods, living necessities had been establishing the connection between the nature and built environment; however, after the industrialization, it is appeared that the aim which forms this connection is this: the purpose of adaptation to ever-changing, differentiating, renewing environmental conditions and needs as well as the purpose of resolving the environmental problems. Depending on the literature research, our work put forward the assertion of that the integration of green areas and built environment is required to be examined at interrelated major 3 design scales and so our work has progressed in this conceptual framework. The major 3 design scales are determined as follows: - City planning scale - Urban design and building groups scale - Individual building scale In the planning scale, formation of the green areas integrated with the physical environment comprise upper decisions in context with sustainability and ecology considered unifying approach. Due to forming fundamental green area structure of the city and also determining the environment character, the planning scale has a special feature of carrying the distinctive upper decisions. In the urban design scale, the integration of green areas and built environment includes without interruption provision of a unifying effect of green areas in a series of interconnected and flowing spaces between the fragmented structure of the building groups. In the architecture scale, the green area involvement to the built environment indicates that setting the planting elements in open space use such as in courtyards and inner gardens as part of the spatial organization and also integrating the building envelope with vegetation by taking advantage of application techniques. This thesis work which aims to transform green area and spatial environment integration into a unifying approach, composed of four chapters: 1. Chapter; comprises the definiton of the problem and presents the theoretical framework of the investigation. 2. Chapter; examine the preservation of natural resources according to the environmental policies. 3. Chapter; evaluate the green areas integrated with built environment within the 3 interralated scales, these are the followings: city planning scale , urban planning and building groups scale and individual building scale. 4. Chapter; contains conclusion of the thesis. In the first chapter; a definition of a relationship between green areas and built environment is determined. The traditional settlements from the ancient times and the industrial revolution are involved in this context. So the assertation of our work related to green areas and built environment integration put forward. Furthermore, the framework of 3 major design scales are explained. In the second chapter, the preservation of natural resources is examined. Depending on the natural environment research, it is clear that the natural resources are integral part of the ecosystem. The principles and decisions related to the natural resource management and their sustainable use include a comprehensive approach for the natural environmental. Therefore, - adaptation to climate change, - preserving the water resources, - preserving forest areas, - preserving biological diversity in the context of environmental policy are priority requirements. Especially, protecting natural values is fundamental in order to develop ecologically sensitive planning and designs. In the third chapter, depending on the literature research, our work put forward the assertion of that integration of green areas and built environment is required to be evaluated at interrelated major 3 design scales and so our work has progressed in this conceptual framework. According to the literature research, the impact of vegetation in the city was important during the previous periods of communities for different reasons. The vegetation was part of nature oriented planning and design initiatives. When urban forms are influenced by the nature, urban identity is composed with the spatial elements that are parts of urban forms. In city planning scale, green area and built environment integration sustain the upper decisions that relates to city. Sustainability and ecological connections are considered in this context. Planning scale includes the unifying green area structure of the city. In urban design scale, when we observe the previously used open spaces, it is seen that they have social functions such as socializing, coming together, creating a common identity, communicating and establishing a connection with the adjacent spaces. In the period of looking for the ecologically compatible space design; urban design came forward as part of environmental design developments. As part of the building group design development, various green area aspects enrich the space character. Strengthening the scenery orientation of the building, including shaded walkways in open space that are provided between the buildings, creating transparent space organization between the interior and exterior of the building contribute to the urban environment. Green areas are natural elements that have an effective and important role in forming the physical environment. Vegetation defines the urban forms, unify, seperate, direct and emphasize continuity with its dimension, texture and distribution. In the individual building scale; integration of green areas with built environment includes that the form of the building allows for the courtyards and inner gardens, underground building envelops connect with the surrounding topography, vegetation is used as a structural component in vegetated roofs and facades. In the individual building scale, the relationship between the green areas and built environment is composed of the following areas: - Courtyard and inner gardens - Building envelope integrated with vegetation When the building structure form the courtyards, the spatial organization defines the open space. Continuity of green areas into the inner gardens enrich the space character. In this space organization, climatic benefits such as daylight and air circulation also contribute to the ecological aspects of the open space use. The recently developed application techniques enable to integrate the vegetation to the building as part of its structural component. The scope of the building envelope integrated with vegetation is explained as follows: - Underground building envelope - Vegetated roof - Vegetated facade In the forth chapter, the conclusions of this thesis work obtained along with the discussions of each part of the conceptual framework. Accordingly, this thesis conclude that it is fundamentally required to focus on the related major 3 design scale that are following; city planning scale, urban design and building group scale and the individual building scale in order to evaluate the green areas integration with built environment., Yüksek Lisans, M.Sc.
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- 2014
11. Advancing Cholangiocarcinoma Care: Insights and Innovations in T Cell Therapy.
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Dadgar N, Arunachalam AK, Hong H, Phoon YP, Arpi-Palacios JE, Uysal M, Wehrle CJ, Aucejo F, Ma WW, and Melenhorst JJ
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Cholangiocarcinoma (CCA) is a rare and aggressive malignancy originating from the bile ducts, with poor prognosis and limited treatment options. Traditional therapies, such as surgery, chemotherapy, and radiation, have shown limited efficacy, especially in advanced cases. Recent advancements in immunotherapy, particularly T cell-based therapies like chimeric antigen receptor T (CAR T) cells, tumor-infiltrating lymphocytes (TILs), and T cell receptor (TCR)-based therapies, have opened new avenues for improving outcomes in CCA. This review provides a comprehensive overview of the current state of T cell therapies for CCA, focusing on CAR T cell therapy. It highlights key challenges, including the complex tumor microenvironment and immune evasion mechanisms, and the progress made in preclinical and clinical trials. The review also discusses ongoing clinical trials targeting specific CCA antigens, such as MUC1, EGFR, and CD133, and the evolving role of precision immunotherapy in enhancing treatment outcomes. Despite significant progress, further research is needed to optimize these therapies for solid tumors like CCA. By summarizing the most recent clinical results and future directions, this review underscores the promising potential of T cell therapies in revolutionizing CCA treatment.
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- 2024
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12. Utility of circulating tumor DNA in secondary liver malignancies: What we know and what is to come.
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Wehrle CJ, Tocci NX, Sun K, Jiao C, Hong H, Gross A, Allkushi E, Uysal M, Linganna MW, Stackhouse K, Hashimoto K, Schlegel A, Walsh RM, Miller C, Kwon DCH, and Aucejo F
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Secondary liver malignancies are a serious and challenging global health concern. Secondary metastasis to the liver is most commonly from colorectal cancer that has metastatically spread through splanchnic circulation. Metastatic diseases can portend poor prognosis due to the progressive nature typically found on detection. Improvements in detection of disease, monitoring therapy response, and monitoring for recurrence are crucial to the improvement in the management of secondary liver malignancies. Assessment of ctDNA in these patient populations poses an opportunity to impact the management of secondary liver malignancies. In this review, we aim to discuss ctDNA, the current literature, and future directions of this technology within secondary liver malignancies., (© 2024 The Author(s). Journal of Surgical Oncology published by Wiley Periodicals LLC.)
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- 2024
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13. Circulating tumor DNA in management of primary liver malignancy: A review of the literature and future directions.
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Tocci NX, Wehrle CJ, Sun K, Jiao C, Hong H, Gross A, Allkushi E, Uysal M, Linganna MW, Stackhouse K, Hashimoto K, Schlegel A, Walsh RM, Miller C, Kwon DCH, and Aucejo F
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Primary liver malignancies are a serious and challenging global health concern. The most common primary tumors are hepatocellular carcinoma and cholangiocarcinoma. These diseases portend poor prognosis when presenting with progressive, extensive disease. There is a critical need for improved diagnosis, therapeutic intervention, and monitoring surveillance in liver-related malignancies. Liquid biopsy using ctDNA provides an opportunity for growth within these domains for liver-related malignancy. However, ctDNA is relatively understudied in this field compared with other solid tumor types, possibly due to the complex nature of the pathology. In this review, we aim to discuss ctDNA, the current literature, and future directions of this technology within primary liver malignancies., (© 2024 The Author(s). Journal of Surgical Oncology published by Wiley Periodicals LLC.)
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- 2024
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14. The use of artificial intelligence to detect parathyroid tissue on ex vivo specimens during thyroidectomy and parathyroidectomy procedures using near-infrared autofluorescence signals.
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Akgun E, Uysal M, Avci SN, and Berber E
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Background: In thyroidectomy and parathyroidectomy procedures, diagnostic dilemmas related to whether an index tissue is of parathyroid or nonparathyroid origin frequently arise. Current options of frozen section and parathyroid aspiration are time-consuming. Parathyroid glands appear brighter than surrounding tissues on near-infrared autofluorescence imaging. The aim of this study was to develop an artificial intelligence model differentiating parathyroid tissue on surgical specimens based on near-infrared autofluorescence., Methods: With institutional review board approval, an image library of ex vivo specimens obtained in thyroidectomy and parathyroidectomy procedures was created between November 2019 and April 2023 at a single academic center. Ex vivo autofluorescence images of surgically removed parathyroid glands, thyroid glands, lymph nodes, and thymic tissue were uploaded into an artificial intelligence platform. Two different models were trained, with the first model using autofluorescence images from all specimens, including thyroid, and the second model excluding thyroid, to prevent the effect of specimen size on the results. Deep-learning models were trained to detect autofluorescence signals specific to parathyroid glands. Randomly chosen 80% of data were used for training, 10% for validation, and 10% for testing. Recall, precision, and area under the curve of models were calculated., Results: Surgical procedures included 377 parathyroidectomies, 239 total thyroidectomies, 97 thyroid lobectomies, and 32 central neck dissections. For the development of the model, 1151 images from a total of 678 procedures were used. The dataset comprised 648 parathyroid, 379 thyroid, 104 lymph node, and 20 thymic tissue images. The overall precision, recall, and area under the curve of the model to detect parathyroid tissue were 96.5%, 96.5%, and 0.985, respectively. False negatives were related to dark and large parathyroid glands., Conclusion: The visual deep-learning model developed to identify parathyroid tissue in ex vivo specimens during thyroidectomy and parathyroidectomy demonstrated a high sensitivity and positive predictive value. This suggests potential utility of near-infrared autofluorescence imaging to improve intraoperative efficiency by reducing the need for frozen sections and parathyroid hormone aspirations to confirm parathyroid tissue., (Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)
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- 2024
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15. Intensive locoregional therapy before liver transplantation for colorectal cancer liver metastasis: A novel pretransplant protocol.
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Wehrle CJ, Fujiki M, Schlegel A, Uysal M, Sobotka A, Whitsett Linganna M, Modaresi Esfeh J, Kamath S, Khalil M, Pita A, Kim JK, Kwon DC, Miller C, Hashimoto K, and Aucejo F
- Abstract
We describe a novel pre-liver transplant (LT) approach in colorectal liver metastasis, allowing for improved monitoring of tumor biology and reduction of disease burden before committing a patient to transplantation. Patients undergoing LT for colorectal liver metastasis at Cleveland Clinic were included. The described protocol involves intensive locoregional therapy with systemic chemotherapy, aiming to reach minimal disease burden revealed by positron emission tomography scan and carcinoembryonic Ag. Patients with no detectable disease or irreversible treatment-induced liver injury undergo transplant. Nine patients received liver transplant out of 27 who were evaluated (33.3%). The median follow-up was 700 days. Seven patients (77.8%) received a living donor LT. Five had no detectable disease, and 4 had treatment-induced cirrhosis. Pretransplant management included chemotherapy (n = 9) +/- bevacizumab (n = 6) and/or anti-EGFR (n = 6). The median number of pre-LT cycles of chemotherapy was 16 (range 10-40). Liver-directed therapy included Yttrium-90 (n = 5), ablation (n = 4), resection (n = 4), and hepatic artery infusion pump (n = 3). Three patients recurred after LT. Actuarial 1- and 2-year recurrence-free survival were 75% (n = 6/8) and 60% (n = 3/5). Recurrence occurred in the lungs (n = 1), liver graft (n = 1), and lungs+para-aortic nodes (n = 1). Patients with pre-LT detectable disease had reduced RFS ( p = 0.04). All patients with recurrence had histologically viable tumors in the liver explant. Patients treated in our protocol (n = 16) demonstrated improved survival versus those who were not candidates (n = 11) regardless of transplant status ( p = 0.01). A protocol defined by aggressive pretransplant liver-directed treatment and transplant for patients with the undetectable disease or treatment-induced liver injury may help prevent tumor recurrence., (Copyright © 2024 American Association for the Study of Liver Diseases.)
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- 2024
- Full Text
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