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The fundamental purpose of every investor making investments in financial fields, is to make profit by buying an investment instrument at a low price and selling the same at a higher price. In this study, within the framework of the aforementioned standpoint, an effective “Trading” decision support model was designed, which can be used for stock market analyses, parity analyses, index analyses, and for the stock analyses of other stock exchanges, briefly for all investment instruments for which candlestick charts are created. An innovative model design was achieved through a bilateral perspective with both financial and scientific aspects by designing these models that operated on a pattern detection basis. The study incorporated the use of 2D candlestick charts of the BIST stocks. The charts were labeled in two separate data sets. Initially, 10,000 pieces of data were labeled on 550 2D candlestick charts, which were trained with YoloV3 Data Group-1 (DG-1). Subsequently, the data set was increased to 20,000 pieces. Out of this set of 20,000 labeled data prepared, 10,000 labeled data were picked randomly. The newly-created set of 10,000 labeled data was named DG-2, which was trained with the YoloV3, YoloV4, Faster R-CNN, SDD algorithms. An assessment was made regarding the performance results obtained following the trainings implemented for these four chosen algorithms. For the aforementioned assessment, three different scenarios were created, and out of all these scenarios, the YoloV3 DG-2 algorithm, which was trained with an improved data set, was observed to be most successful one. As a result of the comparative test scenarios, the YoloV3 DG-2 model achieved a pattern recognition success of 98%. On the other hand, it was also observed to have achieved a prediction success of 100%, while bringing in a return by 89.94%, regarding the object class detected. In addition, no additional parameters were used in this observed gain success. Consequently, the YoloV3 DG-2, determined as the final model, could be implemented as a decision support model for all investment instruments for which a candlestick chart can be created.

This study aims to explore new therapeutic opportunities for histone deacetylase (HDAC) inhibitors by leveraging drug repurposing approaches and analyzing their bioactivity and molecular fingerprints. The methodology includes investigating drug repurposing opportunities for HDAC inhibitors, evaluating the bioactivity of repurposing drugs on HDAC enzymes, investigating the role of HDAC genes in therapeutic effects, and analyzing molecular fingerprints with explainable artificial intelligence (XAI) to identify structurally similar compounds with potential HDAC inhibitory activity. In this context, chemical compounds with IC50 (7903 compounds) and Inhibition (1084 compounds) standard types of HDAC genes reported to be associated with childhood acute leukemia were represented by molecular fingerprints. Regression and classification models were applied to the molecular fingerprints, and the results obtained were supported by XAI. All the study results were shared interactively on the website address https://iuysal1905-childhoodacuteleukemia-drug-interacito-arayuz-r89zld.streamlit.app/ by designing a simulation environment. The influence of molecular fingerprints on the models and their impact on potential drug development in childhood acute leukemia were evaluated using XAI techniques, particularly through the analysis of SHAP values. The study contributes to the literature on the use of XAI technology in drug repurposing studies, especially in cancer, the study of molecular properties, and the active use of XAI in drug repurposing studies.

Iron (Fe) chelating medicines and Histone deacetylase (HDAC) inhibitors are two therapy options for hereditary Friedreich's Ataxia that have been shown to improve clinical results (FA). Fe chelation molecules can minimize the quantity of stored Fe, and HDAC inhibitors can boost the expression of the Frataxin (FXN) gene in enhancing FA. A complete quantitative structure-activity relationship (QSAR) search of inhibitors from the ChEMBL database is reported in this paper, which includes 437 compounds for Fe chelation and 1,354 compounds for HDAC inhibitors. For further investigation, the IC50 was chosen as the unit of bioactivity, and following data refinement, a final dataset of 436 and 1,163 compounds for Fe chelation and HDAC inhibition, respectively, was produced. The Random Forest (RF) technique was used to generate models (train R2 score, 0.701 and 0.892; test R2 score 0.572 and 0.460, for Fe and HDAC, respectively). The models created using the PubChem fingerprint were the strongest of the 12 fingerprint kinds; hence that feature was chosen for interpretation. The results showed the importance of properties related to nitrogen-containing functional groups (SHAP value of PubchemFP656 is -0.29) and aromatic rings (SHAP value of PubchemFP12 is -0.16). As a result, we explained the effect of the molecular fingerprints on the models and the impact on possible drugs that can be developed for FA with artificial intelligence (XAI), which can be explained through SHAP (Shapley Additive Explanations) values. Model scripts and fingerprinting methods are also available at https://github.com/tissueandcells/XAI.

Task Scheduling is an enormous challenge in cloud computing model as to map diverse tasks arises from various sources there should be an efficient scheduling mechanism which provision resources dynamically to users based on their corresponding requests. Ineffective scheduling leads to increase in makespan, energy consumption and violates SLA made between cloud user and service provider thereby quality of service will be degraded and trust on the cloud service provider will be degraded. Trust typically based on quality-of-service parameters such as Availability of virtual resources, Success rate of tasks, Turnaround efficiency of tasks which are included in SLA. In this paper, we designed a Multi objective trust aware scheduler which takes priority of tasks, VMs and schedule tasks to appropriate virtual resources while minimizing makespan, energy consumption. Whale Optimization algorithm used to model our task scheduler. Entire simulation carried out on Cloudsim. Workload used in this simulation is of both fabricated and real-time worklogs captured from HPC2N and NASA. Our proposed approach compared against existing metaheuristic approaches i.e., ACO, GA, PSO approaches. From Simulation results, we observed that there is a significant improvement in makespan, Energy consumption, total running time and trust parameters i.e., Availability, Success rate, Turnaround efficiency.

Scoliosis is a disease caused by the spine curving. It is treatable but physiotherapists may do different measurements for curvature angles. That’s a problem affecting the treatment planning. This study aims to develop a Deep Learning-based decision support system, which diagnoses scoliosis and plans treatments via Schroth method. The system has an interpretable and explainable CapsNet model processing x-ray image to detect 68-point vertebrae and make Cobb angle measurements. By using angle values and patient parameters, treatment is planned through an automated Schroth definition and the Fuzzy Logic. In the evaluations, the CapsNet had dominating findings (some of them are MSE: 0.0038, PCC: 0.93, Accuracy: 0.98). The Fuzzy Logic model was accurate at exercise plans for past cases. Also, physiotherapists and patients had positive feedback for the system usage, trustworthiness, diagnosis, treatment planning and tracking. As a conclusion, the system ensures advancements for automated diagnosis and treatment of scoliosis.

Blockchain systems are popular technologies that have recently emerged. As a decentralized system, blockchain technology has provided many solutions and many problems associated with these solutions. One of its most important problems is that while performing hash calculations very intensively to create a new consensus block, it reduces its efficiency depending on the duration. In this study, a new model to avoid Proof of Work (PoW), which directs the computations made to create blocks to optimization algorithms, is proposed. The proof mechanism proposed in this study is called Proof of Optimization (PoO). A traveling salesman problem (TSP) is entered into the designed system to solve the optimization algorithms. Nodes are asked to solve the TSP in certain iterations and populations. As a result, nodes are asked to create blocks with the fitness, density and time values obtained. PoO and PoW consensus algorithms were subjected to an experimental comparison in the system. The test results show that the block generation time of the PoO consensus model varies between 2 s according to the dataset solution with the least cities (ulysses22) and 60 s according to the dataset solution with the most cities (gr666). Additionally, as a result of experimental analyses, it was determined that decentralization, which is the percentage of block creation among miners in the blockchain, reached a more stable value and the fairness index rose above 0.90 on average. When the obtained values were compared with PoW, it was observed that the block time was more stable and the decentralization of the blockchain was higher. In this way, high-equipped nodes in the blockchain system are prevented from dominating the network. Thus, it is ensured that low-equipped nodes have the right to create blocks in the blockchain. The difficulty levels of the problems can be adjusted by changing the number of cities in the TSP evaluated in this study. In this way, the problem of creating blocks in the network can be made more difficult or easier at any time.

Earning via real-time predictions with the experience in the visible trend directions of an investment instrument in the past requires a different perspective on charts. Indicators and formations within the scope of technical analysis constitute the most significant basis of this perspective. Those who can generate a high income in financial markets and even be more successful than large companies are actually the ones interpreting the data in a different way. In this study, a model which had never been encountered in the literature before, was designed through a different perspective on the same data, enabling the movements of an investment element over the 2D candlestick chart to be recognized as a “Buy-Sell” object respectively and to decide on the trend direction as a result. The model is trained by state-of-the-art, real-time object detection system (You Only Look Once) YOLO; for the training, one-year candlestick charts belonging to the stocks traded on Borsa İstanbul (BIST) between 2000-2018 were used. The model, which can make a “Buy-Sell” decision without the need for an additional time series except for the views on the visual candlestick charts, is promising in terms of its successful predictions. Its ultimate aim is to provide a foresight strengthening the “Buy-Sell” decisions to be made in the decision-making process following the other basic and technical analyses in addition to its stand-alone use in making investment decisions. The effect of this foresight on the success can clearly be seen on the test results received. In the results, the model was found to be successful by 85% while a 100% profit was generated. Besides, the model can be used for all the time series for which candlestick charts can be created.

Nowadays, artificial intelligence is widely used in many biomedical-oriented problems. Because of obtained effective and efficient results, the use of intelligent solution mechanisms by artificial intelligence techniques is mainly focused on healthcare applications. Moving from the explanations, the objective of this paper is to provide an adaptive neuro-fuzzy inference system (ANFIS) trained by a recent optimization algorithm: electro-search optimization (ESO) for predicting the electroencephalogram (EEG) time series. In detail, the research was directed to the EEG time series showing chaotic characteristics so that an effective hybrid system can be designed for having an idea about future states of human brain activity in the case of possible diseases. The developed ANFIS-ESO system was evaluated with five different EEG time series and the obtained findings were reported accordingly. In addition, the ANFIS-ESO system was compared with alternative techniques-systems in order to see the performances according to different systems. In the end, it is possible to mention that the ANFIS-ESO system provides well-enough results in terms of predicting EEG time series. As a result of encouraging results, ANFIS-ESO is currently used actively for real cases.

The concern over security in all fields has intensified over the years. The prefatory phase of providing security begins with authentication to provide access. In many scenarios, this authentication is provided by biometric systems. Moreover, the threat of pandemic has made the people to think of hygienic systems which are noninvasive. Iris image recognition is one such noninvasive biometric system that can provide automated authentication. Self-organizing map is an artificial neural network which helps in iris image recognition. This network has the ability to learn the input features and perform classification. However, from the literature it is observed that the performance of this classifier has scope for refinement to yield better classification. In this paper, heterogeneous methods are adapted to improve the performance of the classifier for iris image recognition. The heterogeneous methods involve the application of Gravity Search Optimization, Teacher Learning Based Optimization, Whale Optimization and Gray Wolf Optimization in the training process of the self-organizing map classifier. This method was tested on iris images from IIT-Delhi database. The results of the experiment show that the proposed method performs better.

Nowadays, there is no application area in which Artificial Intelligence oriented solutions are not employed. It is possible to see its use in even daily life and the solution scope of this scientific field of the future is growing day by day. Because of its great advantages in analyzing the physical world and solving real-world problems, Artificial Intelligence techniques are often employed in different research problems that cannot be solved with traditional computational approaches. In this context, using intelligent systems to understand human features is one of the most popular research interest for recent years. In the sense of the explanations so far, the objective of this study is to introduce a research in which a system that is able to extract emotions from individuals’ facial expressions was designed and developed. In detail, the system considered here a Cascade Feedforward Artificial Neural Network model trained by a recent optimization algorithm called as Vortex Optimization Algorithm. The developed system has been applied to different sets of photos from the literature and positive results were obtained at the final for each different set considered.

In the fields which require finding the most appropriate value, optimization became a vital approach to employ effective solutions. With the use of optimization techniques, many different fields in the modern life have found solutions to their real-world based problems. In this context, classical optimization techniques have had an important popularity. But after a while, more advanced optimization problems required the use of more effective techniques. At this point, Computer Science took an important role on providing software related techniques to improve the associated literature. Today, intelligent optimization techniques based on Artificial Intelligence are widely used for optimization problems. The objective of this paper is to provide a comparative study on the employment of classical optimization solutions and Artificial Intelligence solutions for enabling readers to have idea about the potential of intelligent optimization techniques. At this point, two recently developed intelligent optimization algorithms, Vortex Optimization Algorithm (VOA) and Cognitive Development Optimization Algorithm (CoDOA), have been used to solve some multidisciplinary optimization problems provided in the source book Thomas' Calculus 11th Edition and the obtained results have compared with classical optimization solutions.

The definition, diagnosis and classification of Diabetes Mellitus and its complications are very important. First of all, the World Health Organization (WHO) and other societies, as well as scientists have done lots of studies regarding this subject. One of the most important research interests of this subject is the computer supported decision systems for diagnosing diabetes. In such systems, Artificial Intelligence techniques are often used for several disease diagnostics to streamline the diagnostic process in daily routine and avoid misdiagnosis. In this study, a diabetes diagnosis system, which is formed via both Support Vector Machines (SVM) and Cognitive Development Optimization Algorithm (CoDOA) has been proposed. Along the training of SVM, CoDOA was used for determining the sigma parameter of the Gauss (RBF) kernel function, and eventually, a classification process was made over the diabetes data set, which is related to Pima Indians. The proposed approach offers an alternative solution to the field of Artificial Intelligence-based diabetes diagnosis, and contributes to the related literature on diagnosis processes.

The objective of this paper is to introduce an artificial intelligence based optimization approach, which is inspired from Piaget’s theory on cognitive development. The approach has been designed according to essential processes that an individual may experience while learning something new or improving his / her knowledge. These processes are associated with the Piaget’s ideas on an individual’s cognitive development. The approach expressed in this paper is a simple algorithm employing swarm intelligence oriented tasks in order to overcome single-objective optimization problems. For evaluating effectiveness of this early version of the algorithm, test operations have been done via some benchmark functions. The obtained results show that the approach / algorithm can be an alternative to the literature in terms of single-objective optimization.The authors have suggested the name: Cognitive Development Optimization Algorithm (CoDOA) for the related intelligent optimization approach.

In this paper, the idea of a new artificial intelligence based optimization algorithm, which is inspired from the nature of vortex, has been provided briefly. As also a bio-inspired computation algorithm, the idea is generally focused on a typical vortex flow / behavior in nature and inspires from some dynamics that are occurred in the sense of vortex nature. Briefly, the algorithm is also a swarm-oriented evolutional problem solution approach; because it includes many methods related to elimination of weak swarm members and trying to improve the solution process by supporting the solution space via new swarm members. In order have better idea about success of the algorithm; it has been tested via some benchmark functions. At this point, the obtained results show that the algorithm can be an alternative to the literature in terms of single-objective optimizationsolution ways. Vortex Optimization Algorithm (VOA) is the name suggestion by the authors; for this new idea of intelligent optimization approach.

The prediction of future events based on available time series measurements is a relevant research area specifically for healthcare, such as prognostics and assessments of intervention applications. A measure of brain dynamics, electroencephalogram time series, are routinely analyzed to obtain information about current, as well as future, mental states, and to detect and diagnose diseases or environmental factors. Due to their chaotic nature, electroencephalogram time series require specialized techniques for effective prediction. The objective of this study was to introduce a hybrid system developed by artificial intelligence techniques to deal with electroencephalogram time series. Both artificial neural networks and the ant-lion optimizer, which is a recent intelligent optimization technique, were employed to comprehend the related system and perform some prediction applications over electroencephalogram time series. According to the obtained findings, the system can successfully predict the future states of target time series and it even outperforms some other hybrid artificial neural network-based systems and alternative time series prediction approaches from the literature.

The objective of this paper is to focus on the technical issues of single-stage thermo-electric coolers (TECs) and two-stage TECs and then apply new methods in optimizing the dimensions of TECs. In detail, some metaheuristics—simulated annealing (SA) and differential evolution (DE)—are applied to search the optimal design parameters of both types of TEC, which yielded cooling rates and coefficients of performance (COPs) individually and simultaneously. The optimization findings obtained by using SA and DE are validated by applying them in some defined test cases taking into consideration non-linear inequality and non-linear equality constraint conditions. The performance of SA and DE are verified after comparing the findings with the ones obtained applying the genetic algorithm (GA) and hybridization technique (HSAGA and HSADE). Mathematical modelling and parameter setting of TEC is combined with SA and DE to find better optimal findings. The work revealed that SA and DE can be applied successfully to solve single-objective and multi-objective TEC optimization problems. In terms of stability, reliability, robustness and computational efficiency, they provide better performance than GA. Multi-objective optimizations considering both objective functions are useful for the designer to find the suitable design parameters of TECs which balance the important roles of cooling rate and COP.