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2. Ultrasound-Induced Prenatal Stress: New Possibilities for Modeling Mental Disorders.

Author

Abramova, Olga, Morozova, Anna, Zubkov, Eugene, Ushakova, Valeria, Zorkina, Yana, Proshin, Andrey T., Storozheva, Zinaida, Gurina, Olga, and Chekhonin, Vladimir

Abstract

The development of animal models of mental disorders is an important task since such models are useful for studying the neurobiological mechanisms of psychopathologies and for trial of new therapeutic drugs. One way to model pathologies of the nervous system is to impair fetal neurodevelopment through stress of the pregnant future mother, or prenatal stress (PS). The use of variable frequency ultrasound (US) in rodents is a promising method of imitating psychological stress, to which women in modern society are most often subjected. The aim of our study was to investigate the effect of PS induced by exposure to variable frequency ultrasound (US PS) throughout the gestational period on the adult rat offspring, namely, to identify features of behavioral alterations and neurochemical brain parameters that can be associated with certain mental disorders in humans, to determine the possibility of creating a new model of psychopathology. Our study included a study of some behavioral characteristics of male and female rats in the elevated plus maze, open-field test, object recognition test, social interaction test, sucrose preference test, latent inhibition test, Morris water maze, forced swimming test, acoustic startle reflex, and prepulse inhibition tests. We also determined the activity of the serotonergic, dopaminergic, and noradrenergic neurotransmitter systems in the hippocampus and frontal cortex by HPLC-ED. Concentration of norepinephrine, dopamine, DOPAC, serotonin, and HIAA, as well as DOPAC/dopamine and HIAA/serotonin ratios were determined. A correlation analysis of behavioral and neurochemical parameters in male and female rats was performed based on the data obtained. The results of the study showed that US PS altered the behavioral phenotype of the rat offspring. US PS increased the level of anxious behavior, impaired orientation-research behavior, increased grooming activity, decreased the desire for social contacts, shifted behavioral reactions from social interaction to interaction with inanimate objects, impaired latent inhibition, and decreased the startle reflex. US PS activated the serotonergic, dopaminergic, and noradrenergic neurotransmitter systems of the rat frontal cortex and hippocampus. A correlation between neurochemical and behavioral parameters was revealed. Our study showed that US PS leads to a certain dysfunction on behavioral and neurochemical levels in rats that is most closely associated with symptoms of schizophrenia or autism. We hypothesize that this could potentially be an indicator of face validity for a model of psychopathology based on neurodevelopmental impairment. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Lipids in Psychiatric Disorders: Functional and Potential Diagnostic Role as Blood Biomarkers

Author

Zorkina, Yana, primary, Ushakova, Valeria, additional, Ochneva, Aleksandra, additional, Tsurina, Anna, additional, Abramova, Olga, additional, Savenkova, Valeria, additional, Goncharova, Anna, additional, Alekseenko, Irina, additional, Morozova, Irina, additional, Riabinina, Daria, additional, Kostyuk, Georgy, additional, and Morozova, Anna, additional

Published
2024
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5. Inflammatory biomarkers and lipid metabolism parameters in women with mild cognitive impairment and dementia

Author

Zorkina, Yana, primary, Abramova, Olga, additional, Ushakova, Valeria, additional, Andreyuk, Denis, additional, Andriushchenko, Nika, additional, Pavlov, Konstantin, additional, Savilov, Victor, additional, Soloveva, Kristina, additional, Kurmishev, Marat, additional, Syunyakov, Timur, additional, Karpenko, Olga, additional, Andryushchenko, Alisa, additional, Gurina, Olga, additional, Kostyuk, Georgiy, additional, and Morozova, Anna, additional

Published
2023
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6. Chitosan Aerogel Particles as Nasal Drug Delivery Systems

Author

Menshutina, Natalia, primary, Majouga, Alexander, additional, Uvarova, Anastasia, additional, Lovskaya, Daria, additional, Tsygankov, Pavel, additional, Mochalova, Maria, additional, Abramova, Olga, additional, Ushakova, Valeria, additional, Morozova, Anna, additional, and Silantyev, Artemiy, additional

Published
2022
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10. Peptide LCGA-17 Attenuates Behavioral and Neurochemical Deficits in Rodent Models of PTSD and Depression

Author

Malyshev, Anton V., primary, Sukhanova, Iuliia A., additional, Ushakova, Valeria M., additional, Zorkina, Yana A., additional, Abramova, Olga V., additional, Morozova, Anna Y., additional, Zubkov, Eugene A., additional, Mitkin, Nikita A., additional, Pavshintsev, Vsevolod V., additional, Doronin, Igor I., additional, Gedzun, Vasilina R., additional, Babkin, Gennady A., additional, Sanchez, Sergio A., additional, Baker, Miah D., additional, and Haile, Colin N., additional

Published
2022
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11. Brain Metabolic Profile after Intranasal vs. Intraperitoneal Clomipramine Treatment in Rats with Ultrasound Model of Depression

Author

Abramova, Olga, primary, Zorkina, Yana, additional, Syunyakov, Timur, additional, Zubkov, Eugene, additional, Ushakova, Valeria, additional, Silantyev, Artemiy, additional, Soloveva, Kristina, additional, Gurina, Olga, additional, Majouga, Alexander, additional, Morozova, Anna, additional, and Chekhonin, Vladimir, additional

Published
2021
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12. Associations of Genetic Polymorphisms and Neuroimmune Markers With Some Parameters of Frontal Lobe Dysfunction in Schizophrenia

Author

Morozova, Anna, primary, Zorkina, Yana, additional, Pavlov, Konstantine, additional, Pavlova, Olga, additional, Abramova, Olga, additional, Ushakova, Valeria, additional, Mudrak, Alexander V., additional, Zozulya, Svetlana, additional, Otman, Irina, additional, Sarmanova, Zoya, additional, Klyushnik, Tatiana, additional, Reznik, Alexander, additional, Kostyuk, Georgiy, additional, and Chekhonin, Vladimir, additional

Published
2021
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