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2. FODMAP Diet in Celiac Disease and Gluten-Related Disorders.

Author

Usai Satta, Paolo, Mocci, Giammarco, and Lai, Mariantonia

Abstract

Background: Individuals with celiac disease (CD) often report the persistence of gastrointestinal symptoms despite adherence to a gluten-free diet (GFD). A diet rich in fermentable oligo-, di-, and monosaccharides and polyols (FODMAPs) could cause symptoms in CD on a GFD, and conversely a low-FODMAP diet could positively influence the therapeutic management of CD and non-celiac gluten sensitivity (NCGS). The aim of this review was to explore the hypothetical impact of the FODMAD diet and the low-FODMAP diet (LFD) in CD and gluten-related disorders. Methods: A complete online search for FODMAP related to CD, NCGS, and the GFD was carried out using the Pubmed, Medline, and Cochrane databases. Results: Indeed, an LFD could successfully provide symptom relief in GFD-treated CD patients. Fructans, typical components of FODMAPs, have been associated with digestive symptoms in NCGS, and an LFD could improve the clinical picture. According to some evidence, an LFD could also improve the psychological status both in celiac patients on a GFD and in NCGS. However, an LFD should not have a significant impact on gut microbiota. Conclusions: Recent evidence supports the role of FODMAP restriction in CD patients with persistent symptoms on a GFD and in decreasing gastrointestinal disturbances in NCGS, although the GFD still represents the first-line therapy. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Increased Prevalence of Rare Sucrase-isomaltase Pathogenic Variants in Irritable Bowel Syndrome Patients

Author

Garcia-Etxebarria, Koldo, Zheng, Tenghao, Bonfiglio, Ferdinando, Bujanda, Luis, Dlugosz, Aldona, Lindberg, Greger, Schmidt, Peter T, Karling, Pontus, Ohlsson, Bodil, Simren, Magnus, Walter, Susanna, Nardone, Gerardo, Cuomo, Rosario, Usai-Satta, Paolo, Galeazzi, Francesca, Neri, Matteo, Portincasa, Piero, Bellini, Massimo, Barbara, Giovanni, Jonkers, Daisy, Eswaran, Shanti, Chey, William D, Kashyap, Purna, Chang, Lin, Mayer, Emeran A, Wouters, Mira M, Boeckxstaens, Guy, Camilleri, Michael, Franke, Andre, and D’Amato, Mauro

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Chronic Pain, Digestive Diseases, Genetics, Pain Research, Aetiology, 2.1 Biological and endogenous factors, Oral and gastrointestinal, Gene Frequency, Genotype, Humans, Irritable Bowel Syndrome, Prevalence, Sucrase-Isomaltase Complex, Gastroenterology & Hepatology, Clinical sciences
Abstract

Patients with irritable bowel syndrome (IBS) often associate their symptoms to certain foods. In congenital sucrase-isomaltase deficiency (CSID), recessive mutations in the SI gene (coding for the disaccharidase digesting sucrose and 60% of dietary starch)1 cause clinical features of IBS through colonic accumulation of undigested carbohydrates, triggering bowel symptoms.2 Hence, in a previous study,3 we hypothesized that CSID variants reducing SI enzymatic activity may contribute to development of IBS symptoms. We detected association with increased risk of IBS for 4 rare loss-of-function variants typically found in (homozygous) CSID patients, because carriers (heterozygous) of these rare variants were more common in patients than in controls.1,4 Through a 2-step computational and experimental strategy, the present study aimed to determine whether other (dys-)functional SI variants are associated with risk of IBS in addition to known CSID mutations. We first aimed to identify all SI rare pathogenic variants (SI-RPVs) on the basis of integrated Mendelian Clinically Applicable Pathogenicity (M-CAP) and Combined Annotation Dependent Depletion (CADD) predictive (clinically relevant) scores; next, we inspected genotype data currently available for 2207 IBS patients from a large ongoing project to compare SI-RPV case frequencies with ethnically matched population frequencies from the Exome Aggregation Consortium (ExAC).

Published
2018

4. Female-Specific Association Between Variants on Chromosome 9 and Self-Reported Diagnosis of Irritable Bowel Syndrome

Author

Bonfiglio, Ferdinando, Zheng, Tenghao, Garcia-Etxebarria, Koldo, Hadizadeh, Fatemeh, Bujanda, Luis, Bresso, Francesca, Agreus, Lars, Andreasson, Anna, Dlugosz, Aldona, Lindberg, Greger, Schmidt, Peter T, Karling, Pontus, Ohlsson, Bodil, Simren, Magnus, Walter, Susanna, Nardone, Gerardo, Cuomo, Rosario, Usai-Satta, Paolo, Galeazzi, Francesca, Neri, Matteo, Portincasa, Piero, Bellini, Massimo, Barbara, Giovanni, Latiano, Anna, Hübenthal, Matthias, Thijs, Vincent, Netea, Mihai G, Jonkers, Daisy, Chang, Lin, Mayer, Emeran A, Wouters, Mira M, Boeckxstaens, Guy, Camilleri, Michael, Franke, Andre, Zhernakova, Alexandra, and D'Amato, Mauro

Subjects
Genetics, Prevention, Digestive Diseases, Pain Research, Human Genome, 2.1 Biological and endogenous factors, Aetiology, Adult, Aged, Chromosomes, Human, Pair 9, Constipation, Europe, Female, Genetic Predisposition to Disease, Genetic Variation, Genome-Wide Association Study, Genotype, Humans, Irritable Bowel Syndrome, Male, Menarche, Middle Aged, Polymorphism, Single Nucleotide, Self Report, Sex Factors, Sweden, United States, SNP, Biobank Research, Bowel Symptoms, Clinical Sciences, Neurosciences, Paediatrics and Reproductive Medicine, Gastroenterology & Hepatology
Abstract

Background & aimsGenetic factors are believed to affect risk for irritable bowel syndrome (IBS), but there have been no sufficiently powered and adequately sized studies. To identify DNA variants associated with IBS risk, we performed a genome-wide association study (GWAS) of the large UK Biobank population-based cohort, which includes genotype and health data from 500,000 participants.MethodsWe studied 7,287,191 high-quality single nucleotide polymorphisms in individuals who self-reported a doctor's diagnosis of IBS (cases; n = 9576) compared to the remainder of the cohort (controls; n = 336,499) (mean age of study subjects, 40-69 years). Genome-wide significant findings were further investigated in 2045 patients with IBS from tertiary centers and 7955 population controls from Europe and the United States, and a small general population sample from Sweden (n = 249). Functional annotation of GWAS results was carried out by integrating data from multiple biorepositories to obtain biological insights from the observed associations.ResultsWe identified a genome-wide significant association on chromosome 9q31.2 (single nucleotide polymorphism rs10512344; P = 3.57 × 10-8) in a region previously linked to age at menarche, and 13 additional loci of suggestive significance (P < 5.0×10-6). Sex-stratified analyses revealed that the variants at 9q31.2 affect risk of IBS in women only (P = 4.29 × 10-10 in UK Biobank) and also associate with constipation-predominant IBS in women (P = .015 in the tertiary cohort) and harder stools in women (P = .0012 in the population-based sample). Functional annotation of the 9q31.2 locus identified 8 candidate genes, including the elongator complex protein 1 gene (ELP1 or IKBKAP), which is mutated in patients with familial dysautonomia.ConclusionsIn a sufficiently powered GWAS of IBS, we associated variants at the locus 9q31.2 with risk of IBS in women. This observation may provide additional rationale for investigating the role of sex hormones and autonomic dysfunction in IBS.

Published
2018

5. Multisocieties position paper: Microbiological surveillance on flexible endoscopes

Author

Bertoni, Costanza, Curti, Cesarina, Giacomini, Maurizio, Meledandri, Marcello, Palmieri, Dalia, Privitera, Gaetano, Raglio, Annibale, Tuvo, Benedetta, Colombo, Benedetta, Iannone, Teresa, Iori, Giorgio, Giaquinto, Antonella, Minenna, Angela, Petrocelli, Giulio, Valdinoci, Monia, Bortoluzzi, Francesco, Galeazzi, Francesca, Manta, Raffaele, Montalto, Paolo, Segato, Sergio, Soncini, Marco, Usai-Satta, Paolo, Vassallo, Roberto, Ferraiolo, Fabio, Roseto, Fabio, Bezziccheri, Milena, Fighera, Michele, Giampà, Ada, Mancini, Antonio, Marino, Caterina, Cerone, Marina Pisegna, Risitano, Tommaso, Sergio, Emmanuele, Sinopoli, Raffaele, De Caprio, Maria Teresa, Failla, Giuseppe, Agli, Luigi Lazzari, Majori, Maria, Toccaceli, Andrea, Marciano, Emanuele, Maurano, Attilio, Rodella, Luca, Cengia, Gianpaolo, Ciliberto, Enrico, Conigliaro, Rita, Germanà, Bastianello, Lamazza, Antonietta, Pisani, Antonio, Zagari, Rocco Maurizio, Spinzi, Giancarlo, Casini, Beatrice, Pan, Angelo, Guarini, Alessandra, Rivara, Cinzia, Zullo, Angelo, Monica, Fabio, Cimbro, Monica, Casarano, Salvatore, Inglese, Agostino, Vaghi, Adriano, Schiffino, Luigi, Capezzuto, Erminio, Da Massa Carrara, Paola, and Pasquale, Luigi

Published
2021
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6. Changes in digestive cancer diagnosis during the SARS-CoV-2 pandemic in Italy: A nationwide survey

Author

Massironi, Sara, Bianco, Maria Antonia, Germanà, Bastianello, Rodinò, Stefano, Anderloni, Andrea, Mussetto, Alessandro, Nipote, Bruno, Russo, Salvatore, Manta, Raffaele, Lauri, Adriano, Occhipinti, Vincenzo, Marco, Marco Di, Giovannone, Maurizio, Binda, Cecilia, Sbrancia, Monica, Paolo, Maria Carla Di, de’-Angelis, Gian Luigi, Fiori, Giancarla, Dal-Fante, Marco, Caro, Giuseppe de, Usai-Satta, Paolo, Cesarini, Monica, Piras, Enrico, Stasi, Elisa, Serio, Giovanni, Montalbano, Luigi Maria, Mirante, Vincenzo Giorgio, Burattini, Osvaldo, Attardo, Simona, Bargiggia, Stefano, Dinca, Manuele, Missale, Guido, Alvisi, Costanza, Broglia, Francesco, Ferraris, Luca, Conti-Bellocchi, Maria Cristina, Luigiano, Carmelo, Pallio, Socrate, Brunacci, Matteo, Manfrini, Carlo, Bozzi, Rosamaria, Checchin, Davide, Togliani, Thomas, D'errico, Antonietta, Bazzoli, Franco, La Bianca, Orazio, Berretti, Debora, Alvaro, Domenico, Buscarini, Elisabetta, Benedetti, Antonio, Monica, Fabio, Pasquale, Luigi, Buttitta, Francesco, Cameletti, Michela, Ferrari, Clarissa, and Ricciardiello, Luigi

Published
2021
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10. Ustekinumab safety and effectiveness in patients with ulcerative colitis: results from a large real-life study

Author

Tursi, Antonio, Mocci, Giammarco, Scaldaferri, Franco, Napolitano, Daniele, Maresca, Rossella, Pugliese, Daniela, Semprucci, Gianluca, Savarino, Edoardo, Cuomo, Antonio, Donnarumma, Laura, Bodini, Giorgia, Pasta, Andrea, Maconi, Giovanni, Cataletti, Giovanni, Pranzo, Giuseppe, Rodinò, Stefano, Sebkova, Ladislava, Costa, Francesco, Ferronato, Antonio, Gaiani, Federica, Marzo, Manuela, Luppino, Ileana, Fabiano, Giulia, Paese, Pietro, Elisei, Walter, Monterubbianesi, Rita, Faggiani, Roberto, Grossi, Laurino, Serio, Mariaelena, Scarcelli, Antonella, Lorenzetti, Roberto, Allegretta, Leonardo, Chiri, Stefania, Grasso, Giuseppina, Antonelli, Elisabetta, Bassotti, Gabrio, Spagnuolo, Rocco, Luzza, Francesco, Fanigliulo, Libera, Rocco, Giulia, Sacchi, Carlotta, Zampaletta, Costantino, Rocchi, Chiara, Bolognini, Laura, Bendia, Emanuele, Bianco, Maria Antonia, Capone, Pietro, Meucci, Costantino, Colucci, Raffaele, Tonti, Paolo, Neve, Viviana, Della Valle, Nicola, Felice, Carla, Pica, Roberta, Cocco, Andrea, Forti, Giacomo, Onidi, Francesca Maria, Usai Satta, Paolo, Checchin, Davide, Gravina, Antonietta Gerarda, Pellegrino, Raffaele, Picchio, Marcello, Papa, Alfredo, Scaldaferri, Franco (ORCID:0000-0001-8334-7541), Papa, Alfredo (ORCID:0000-0002-4186-7298), Tursi, Antonio, Mocci, Giammarco, Scaldaferri, Franco, Napolitano, Daniele, Maresca, Rossella, Pugliese, Daniela, Semprucci, Gianluca, Savarino, Edoardo, Cuomo, Antonio, Donnarumma, Laura, Bodini, Giorgia, Pasta, Andrea, Maconi, Giovanni, Cataletti, Giovanni, Pranzo, Giuseppe, Rodinò, Stefano, Sebkova, Ladislava, Costa, Francesco, Ferronato, Antonio, Gaiani, Federica, Marzo, Manuela, Luppino, Ileana, Fabiano, Giulia, Paese, Pietro, Elisei, Walter, Monterubbianesi, Rita, Faggiani, Roberto, Grossi, Laurino, Serio, Mariaelena, Scarcelli, Antonella, Lorenzetti, Roberto, Allegretta, Leonardo, Chiri, Stefania, Grasso, Giuseppina, Antonelli, Elisabetta, Bassotti, Gabrio, Spagnuolo, Rocco, Luzza, Francesco, Fanigliulo, Libera, Rocco, Giulia, Sacchi, Carlotta, Zampaletta, Costantino, Rocchi, Chiara, Bolognini, Laura, Bendia, Emanuele, Bianco, Maria Antonia, Capone, Pietro, Meucci, Costantino, Colucci, Raffaele, Tonti, Paolo, Neve, Viviana, Della Valle, Nicola, Felice, Carla, Pica, Roberta, Cocco, Andrea, Forti, Giacomo, Onidi, Francesca Maria, Usai Satta, Paolo, Checchin, Davide, Gravina, Antonietta Gerarda, Pellegrino, Raffaele, Picchio, Marcello, Papa, Alfredo, Scaldaferri, Franco (ORCID:0000-0001-8334-7541), and Papa, Alfredo (ORCID:0000-0002-4186-7298)

Abstract

BackgroundUstekinumab (UST) is an interleukin-12/interleukin-23 receptor antagonist recently approved for treating ulcerative colitis (UC) but with limited real-world data. Therefore, we evaluated the effectiveness and safety of UST in patients with UC in a real-world setting.Research design and methodsThis is a multicenter, retrospective, observational cohort study. The primary endpoints were the clinical remission rate (partial Mayo score, PMS, <= 1) and the safety of UST. Other endpoints were corticosteroid-free remission (CSFR) rate, clinical response rate (PMS reduction of at least 2 points), and fecal calprotectin (FC) reduction at week 24.ResultsWe included 256 consecutive patients with UC (M/F 139/117, median age 52). The clinical remission and clinical response rates at eight weeks were 18.7% (44/235) and 53.2% (125/235), respectively, and 27.6% (42/152) and 61.8% (94/152) at 24 weeks, respectively. At 24 weeks, CSFR was 20.3% (31/152), and FC significantly dropped at week 12 (p = 0.0004) and 24 (p = 0.038). At eight weeks, patients naive or with one previous biologic treatment showed higher remission (p = 0.002) and clinical response rates (p = 0.018) than patients previously treated with >= 2. Adverse events occurred in six patients (2.3%), whereas four patients (1.6%) underwent colectomy.ConclusionThis real-world study shows that UST effectively and safely treats patients with UC.

Published
2024

11. IBS clinical management in Italy: The AIGO survey

Author

Carrara, Maurizio, Cabras, Francesco, Guerra, Vito, Camilleri, Salvatore, Gambaccini, Dario, Tammaro, Leonardo, D’Alba, Lucia, Turco, Luigi, Gasparini, Paolo, Solinas, Attilio, Russo, Giovanni, Pancetti, Andrea, Salvioli, Beatrice, Anderloni, Andrea, Bassotti, Gabrio, Lai, Maria Antonia, Antonino, Matteo, De Bona, Manuela, Boschetto, Sandro, Rentini, Silvia, Rossitti, Piera, Limido, Eugenio, Balzano, Antonio, Soncini, Marco, Stasi, Cristina, Usai Satta, Paolo, Milazzo, Giuseppe, Bianco, Margherita, Leandro, Gioacchino, Montalbano, Luigi Maria, Muscatiello, Nicola, Monica, Fabio, Galeazzi, Francesca, and Bellini, Massimo

Published
2019
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12. Ustekinumab safety and effectiveness in patients with ulcerative colitis: results from a large real-life study

Author

Tursi, Antonio, primary, Mocci, Giammarco, additional, Scaldaferri, Franco, additional, Napolitano, Daniele, additional, Maresca, Rossella, additional, Pugliese, Daniela, additional, Semprucci, Gianluca, additional, Savarino, Edoardo, additional, Cuomo, Antonio, additional, Donnarumma, Laura, additional, Bodini, Giorgia, additional, Pasta, Andrea, additional, Maconi, Giovanni, additional, Cataletti, Giovanni, additional, Pranzo, Giuseppe, additional, Rodinò, Stefano, additional, Sebkova, Ladislava, additional, Costa, Francesco, additional, Ferronato, Antonio, additional, Gaiani, Federica, additional, Marzo, Manuela, additional, Luppino, Ileana, additional, Fabiano, Giulia, additional, Paese, Pietro, additional, Elisei, Walter, additional, Monterubbianesi, Rita, additional, Faggiani, Roberto, additional, Grossi, Laurino, additional, Serio, Mariaelena, additional, Scarcelli, Antonella, additional, Lorenzetti, Roberto, additional, Allegretta, Leonardo, additional, Chiri, Stefania, additional, Grasso, Giuseppina, additional, Antonelli, Elisabetta, additional, Bassotti, Gabrio, additional, Spagnuolo, Rocco, additional, Luzza, Francesco, additional, Fanigliulo, Libera, additional, Rocco, Giulia, additional, Sacchi, Carlotta, additional, Zampaletta, Costantino, additional, Rocchi, Chiara, additional, Bolognini, Laura, additional, Bendia, Emanuele, additional, Bianco, Maria Antonia, additional, Capone, Pietro, additional, Meucci, Costantino, additional, Colucci, Raffaele, additional, Tonti, Paolo, additional, Neve, Viviana, additional, Della Valle, Nicola, additional, Felice, Carla, additional, Pica, Roberta, additional, Cocco, Andrea, additional, Forti, Giacomo, additional, Onidi, Francesca Maria, additional, Usai Satta, Paolo, additional, Checchin, Davide, additional, Gravina, Antonietta Gerarda, additional, Pellegrino, Raffaele, additional, Picchio, Marcello, additional, and Papa, Alfredo, additional

Published
2024
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13. List of contributors

Author

Alterini, Giada, primary, Bassotti, Gabrio, additional, Bellini, Massimo, additional, Blaga, Teodora Surdea, additional, Blandizzi, Corrado, additional, Brillanti, Stefano, additional, Bronzini, Francesco, additional, Colucci, Rocchina, additional, Dumitrascu, Dan L., additional, D’Mello, Charlotte, additional, Fianchi, Francesca, additional, Fornai, Matteo, additional, Galli, Andrea, additional, Grad, Simona, additional, Kim, Yong-Ku, additional, Laguna de la Vera, Anna-Lena, additional, Maroni, Luca, additional, Miele, Luca, additional, Milani, Stefano, additional, Pfeilschifter, Waltraud, additional, Pop, Andrei V., additional, Samanta, Sandip, additional, Scalese, Giulia, additional, Severi, Carola, additional, Shawcross, Debbie L., additional, Shin, Cheolmin, additional, Stasi, Cristina, additional, Svegliati Baroni, Gianluca, additional, Swain, Mark G., additional, Trebicka, Jonel, additional, Usai Satta, Paolo, additional, and Welsch, Christoph, additional

Published
2021
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15. Upper Gastrointestinal Endoscopy Quality in Italy: A Nationwide Study

Author

Zullo, Angelo, primary, De Francesco, Vincenzo, primary, Amato, Arnaldo, primary, Bergna, Irene, primary, Bendia, Emanuele, primary, Giorgini, Giorgia, primary, Buscarini, Elisabetta, primary, Manfredi, Guido, primary, Cadoni, Sergio, primary, Cannizzaro, Renato, primary, Realdon, Stefano, primary, Ciuffi, Mario, primary, Ignomirelli, Orazio, primary, Da Massa Carrara, Paola, primary, Finucci, Giovanni, primary, Di Somma, Antonietta, primary, Frandina, Chiara, primary, Loria, Mariafrancesca, primary, Galeazzi, Francesca, primary, Ferrara, Francesco, primary, Gemme, Carlo, primary, Bertetti, Noemi Sara, primary, Gentili, Federica, primary, Lotito, Antonio, primary, Germanà, Bastianello, primary, Russo, Nunzia, primary, Grande, Giuseppe, primary, Conigliaro, Rita, primary, Cravero, Federico, primary, Venezia, Giovanna, primary, Marmo, Riccardo, primary, Senneca, Piera, primary, Milano, Angelo, primary, Efthymakis, Konstantinos, primary, Monica, Fabio, primary, Montalto, Paolo, primary, Lombardi, Mario, primary, Morelli, Olivia, primary, Castellani, Danilo, primary, Nigro, Daniela, primary, Festa, Roberto, primary, Peralta, Sergio, primary, Grasso, Maria, primary, Privitera, Antonello, primary, Distefano, Maria Emanuela, primary, Scaccianoce, Giuseppe, primary, Loiacono, Mariangela, primary, Segato, Sergio, primary, Balzarini, Marco, primary, Usai Satta, Paolo, primary, Lai, Mariantonia, primary, and Manta, Raffaele, primary

Published
2023
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16. Misinterpreting Diarrhea-Predominant Irritable Bowel Syndrome and Functional Diarrhea: Pathophysiological Highlights

Author

Sciumè, Giusi Desirè, primary, Berti, Ginevra, additional, Lambiase, Christian, additional, Paglianiti, Italia, additional, Villanacci, Vincenzo, additional, Rettura, Francesco, additional, Grosso, Antonio, additional, Ricchiuti, Angelo, additional, Bortoli, Nicola de, additional, Usai Satta, Paolo, additional, Bassotti, Gabrio, additional, and Bellini, Massimo, additional

Published
2023
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17. Use of tofacitinib as first or second-line therapy is associated with better outcomes in patients with ulcerative colitis: data from a real-world study

Author

Tursi, Antonio, primary, Mocci, Giammarco, additional, Cingolani, Linda, additional, Savarino, Edoardo, additional, Pica, Roberta, additional, Cocco, Andrea, additional, Zippi, Maddalena, additional, Napolitano, Daniele, additional, Schiavoni, Elisa, additional, Pugliese, Daniela, additional, Scaldaferri, Franco, additional, Costa, Francesco, additional, Marzo, Manuela, additional, Serio, Mariaelena, additional, Scarcelli, Antonella, additional, Bolognini, Laura, additional, Bendia, Emanuele, additional, Maconi, Giovanni, additional, Cannatelli, Rosanna, additional, Piergallini, Simona, additional, Bodini, Giorgia, additional, Calabrese, Francesco, additional, Ferronato, Antonio, additional, Pranzo, Giuseppe, additional, Elisei, Walter, additional, Monterubbianesi, Rita, additional, Faggiani, Roberto, additional, Rodinò, Stefano, additional, Sebkova, Ladislava, additional, Grossi, Laurino, additional, Gaiani, Federica, additional, dè Angelis, Gianluigi, additional, Lorenzetti, Roberto, additional, Allegretta, Leonardo, additional, Cazzato, Alessia Immacolata, additional, Scorza, Stefano, additional, Della Valle, Nicola, additional, Sacco, Rodolfo, additional, Forti, Giacomo, additional, Colucci, Raffaele, additional, Tonti, Paolo, additional, Neve, Viviana, additional, Rocco, Giulia, additional, Sacchi, Carlotta, additional, Zampaletta, Costantino, additional, Pagnini, Cristiano, additional, Graziani, Maria Giovanna, additional, Di Paolo, Maria Carla, additional, Onidi, Francesca Maria, additional, Usai Satta, Paolo, additional, Picchio, Marcello, additional, and Papa, Alfredo, additional

Published
2023
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18. Real-world efficacy and safety of vedolizumab in managing ulcerative colitis versus Crohn's disease: results from an Italian multicenter study

Author

Mocci, Giammarco, Tursi, Antonio, Maconi, Giovanni, Cataletti, Giovanni, Mantia, Beatrice, Serio, Mariaelena, Scarcelli, Antonella, Pagnini, Cristiano, Graziani, Maria Giovanna, Di Paolo, Maria Carla, Pranzo, Giuseppe, Luppino, Ileana, Paese, Pietro, Elisei, Walter, Monterubbianesi, Rita, Faggiani, Roberto, Ferronato, Antonio, Perini, Barbara, Savarino, Edoardo, Onidi, Francesca Maria, Binaghi, Laura, Usai Satta, Paolo, Schiavoni, Elisa, Napolitano, Daniele, Scaldaferri, Franco, Pugliese, Daniela, Pica, Roberta, Cocco, Andrea, Zippi, Maddalena, Rodino, Stefano, Sebkova, Ladislava, Rocco, Giulia, Sacchi, Carlotta, Zampaletta, Costantino, Gaiani, Federica, De Angelis, Gianluigi, Kayali, Stefano, Fanigliulo, Libera, Lorenzetti, Roberto, Allegretta, Leonardo, Scorza, Stefano, Cuomo, Antonio, Donnarumma, Laura, Della Valle, Nicola, Sacco, Rodolfo, Forti, Giacomo, Antonelli, Elisabetta, Bassotti, Gabrio, Iannelli, Chiara, Luzza, Francesco, Aragona, Giovanni, Perazzo, Patrizia, Lauria, Angelo, Piergallini, Simona, Colucci, Raffaele, Bianco, Maria Antonia, Meucci, Costantino, Giorgetti, Gianmarco, Clemente, Valeria, Fiorella, Serafina, Penna, Antonio, De Medici, Antonio, Picchio, Marcello, Papa, Alfredo, Scaldaferri, Franco (ORCID:0000-0001-8334-7541), Papa, Alfredo (ORCID:0000-0002-4186-7298), Mocci, Giammarco, Tursi, Antonio, Maconi, Giovanni, Cataletti, Giovanni, Mantia, Beatrice, Serio, Mariaelena, Scarcelli, Antonella, Pagnini, Cristiano, Graziani, Maria Giovanna, Di Paolo, Maria Carla, Pranzo, Giuseppe, Luppino, Ileana, Paese, Pietro, Elisei, Walter, Monterubbianesi, Rita, Faggiani, Roberto, Ferronato, Antonio, Perini, Barbara, Savarino, Edoardo, Onidi, Francesca Maria, Binaghi, Laura, Usai Satta, Paolo, Schiavoni, Elisa, Napolitano, Daniele, Scaldaferri, Franco, Pugliese, Daniela, Pica, Roberta, Cocco, Andrea, Zippi, Maddalena, Rodino, Stefano, Sebkova, Ladislava, Rocco, Giulia, Sacchi, Carlotta, Zampaletta, Costantino, Gaiani, Federica, De Angelis, Gianluigi, Kayali, Stefano, Fanigliulo, Libera, Lorenzetti, Roberto, Allegretta, Leonardo, Scorza, Stefano, Cuomo, Antonio, Donnarumma, Laura, Della Valle, Nicola, Sacco, Rodolfo, Forti, Giacomo, Antonelli, Elisabetta, Bassotti, Gabrio, Iannelli, Chiara, Luzza, Francesco, Aragona, Giovanni, Perazzo, Patrizia, Lauria, Angelo, Piergallini, Simona, Colucci, Raffaele, Bianco, Maria Antonia, Meucci, Costantino, Giorgetti, Gianmarco, Clemente, Valeria, Fiorella, Serafina, Penna, Antonio, De Medici, Antonio, Picchio, Marcello, Papa, Alfredo, Scaldaferri, Franco (ORCID:0000-0001-8334-7541), and Papa, Alfredo (ORCID:0000-0002-4186-7298)

Abstract

BackgroundVedolizumab (VDZ) can be used to treat refractory ulcerative colitis (UC) and Crohn's disease (CD). We assessed whether there are differences in treating UC vs CD with VDZ.Research design and methods Mayo score in UC and the Harvey-Bradshaw Index (HBI) in CD scored the clinical activity. Achievement and maintenance of clinical remission during the follow-up, and safety were the primary endpoints.Results729 patients (475 with UC and 254 with CD), median follow-up of 18 (IQR 6-36) months, were enrolled. Clinical remission at the 6(th) month of treatment was achieved in 488 (66.9%) patients (74.4% in CD vs 62.9% in UC, p<0.002) while, during the follow-up, no difference was found (81.5% in the UC group and 81.5% pts in the CD group; p=0.537). The clinical remission at the 6(th) month of treatment (p=0.001) and being naive to biologics (p<0.0001) were significantly associated with prolonged clinical remission. The clinical response was significantly higher in UC (90.1%) vs CD (84.3%) (p=0.023), and surgery occurred more frequently in CD (1.9% in UC vs 5.1% in CD, p=0.016).ConclusionWe found differences when using VDZ in UC vs CD in real life. These parameters can help the physician predict this drug's longterm efficacy.

Published
2023

19. Use of tofacitinib as first or second-line therapy is associated with better outcomes in patients with ulcerative colitis: data from a real-world study

Author

Tursi, Antonio, Mocci, Giammarco, Cingolani, Linda, Savarino, Edoardo, Pica, Roberta, Cocco, Andrea, Zippi, Maddalena, Napolitano, Daniele, Schiavoni, Elisa, Pugliese, Daniela, Scaldaferri, Franco, Costa, Francesco, Marzo, Manuela, Serio, Mariaelena, Scarcelli, Antonella, Bolognini, Laura, Bendia, Emanuele, Maconi, Giovanni, Cannatelli, Rosanna, Piergallini, Simona, Bodini, Giorgia, Calabrese, Francesco, Ferronato, Antonio, Pranzo, Giuseppe, Elisei, Walter, Monterubbianesi, Rita, Faggiani, Roberto, Rodinò, Stefano, Sebkova, Ladislava, Grossi, Laurino, Gaiani, Federica, dè Angelis, Gianluigi, Lorenzetti, Roberto, Allegretta, Leonardo, Cazzato, Alessia Immacolata, Scorza, Stefano, Della Valle, Nicola, Sacco, Rodolfo, Forti, Giacomo, Colucci, Raffaele, Tonti, Paolo, Neve, Viviana, Rocco, Giulia, Sacchi, Carlotta, Zampaletta, Costantino, Pagnini, Cristiano, Graziani, Maria Giovanna, Di Paolo, Maria Carla, Onidi, Francesca Maria, Usai Satta, Paolo, Picchio, Marcello, Papa, Alfredo, Scaldaferri, Franco (ORCID:0000-0001-8334-7541), Papa, Alfredo (ORCID:0000-0002-4186-7298), Tursi, Antonio, Mocci, Giammarco, Cingolani, Linda, Savarino, Edoardo, Pica, Roberta, Cocco, Andrea, Zippi, Maddalena, Napolitano, Daniele, Schiavoni, Elisa, Pugliese, Daniela, Scaldaferri, Franco, Costa, Francesco, Marzo, Manuela, Serio, Mariaelena, Scarcelli, Antonella, Bolognini, Laura, Bendia, Emanuele, Maconi, Giovanni, Cannatelli, Rosanna, Piergallini, Simona, Bodini, Giorgia, Calabrese, Francesco, Ferronato, Antonio, Pranzo, Giuseppe, Elisei, Walter, Monterubbianesi, Rita, Faggiani, Roberto, Rodinò, Stefano, Sebkova, Ladislava, Grossi, Laurino, Gaiani, Federica, dè Angelis, Gianluigi, Lorenzetti, Roberto, Allegretta, Leonardo, Cazzato, Alessia Immacolata, Scorza, Stefano, Della Valle, Nicola, Sacco, Rodolfo, Forti, Giacomo, Colucci, Raffaele, Tonti, Paolo, Neve, Viviana, Rocco, Giulia, Sacchi, Carlotta, Zampaletta, Costantino, Pagnini, Cristiano, Graziani, Maria Giovanna, Di Paolo, Maria Carla, Onidi, Francesca Maria, Usai Satta, Paolo, Picchio, Marcello, Papa, Alfredo, Scaldaferri, Franco (ORCID:0000-0001-8334-7541), and Papa, Alfredo (ORCID:0000-0002-4186-7298)

Abstract

BackgroundData regarding the real-world (RW) use of tofacitinib (TOF) in patients with ulcerative colitis (UC) are limited. We aimed to investigate TOF's RW efficacy and safety in Italian UC patients.Research design and methodsA retrospective assessment of clinical and endoscopic activity was performed according to the Mayo score. The primary endpoints were to evaluate the effectiveness and safety of TOF.ResultsWe enrolled 166 patients with a median follow-up of 24 (IQR 8-36) weeks. Clinical remission was achieved in 61/166 (36.7%) and 75/166 (45.2%) patients at 8-week and 24-week follow-ups, respectively. The optimization was requested in 27 (16.3%) patients. Clinical remission was achieved more frequently when TOF was used as a first/second line rather than a third/fourth line treatment (p = 0.007). Mucosal healing was reported in 46% of patients at the median follow-up time. Colectomy occurred in 8 (4.8%) patients. Adverse events occurred in 12 (5.4%) patients and severe in 3 (1.8%). One case of simple Herpes Zoster and one of renal vein thrombosis were recorded.ConclusionsOur RW data confirm that TOF is effective and safe in UC patients. It performs remarkably better when used as the first/second line of treatment.

Published
2023

21. Real-world efficacy and safety of vedolizumab in managing ulcerative colitis versus Crohn’s disease: results from an Italian multicenter study

Author

Mocci, Giammarco, primary, Tursi, Antonio, additional, Maconi, Giovanni, additional, Cataletti, Giovanni, additional, Mantia, Beatrice, additional, Serio, Mariaelena, additional, Scarcelli, Antonella, additional, Pagnini, Cristiano, additional, Graziani, Maria Giovanna, additional, Di Paolo, Maria Carla, additional, Pranzo, Giuseppe, additional, Luppino, Ileana, additional, Paese, Pietro, additional, Elisei, Walter, additional, Monterubbianesi, Rita, additional, Faggiani, Roberto, additional, Ferronato, Antonio, additional, Perini, Barbara, additional, Savarino, Edoardo, additional, Onidi, Francesca Maria, additional, Binaghi, Laura, additional, Usai Satta, Paolo, additional, Schiavoni, Elisa, additional, Napolitano, Daniele, additional, Scaldaferri, Franco, additional, Pugliese, Daniela, additional, Pica, Roberta, additional, Cocco, Andrea, additional, Zippi, Maddalena, additional, Rodino, Stefano, additional, Sebkova, Ladislava, additional, Rocco, Giulia, additional, Sacchi, Carlotta, additional, Zampaletta, Costantino, additional, Gaiani, Federica, additional, De Angelis, Gianluigi, additional, Kayali, Stefano, additional, Fanigliulo, Libera, additional, Lorenzetti, Roberto, additional, Allegretta, Leonardo, additional, Scorza, Stefano, additional, Cuomo, Antonio, additional, Donnarumma, Laura, additional, Della Valle, Nicola, additional, Sacco, Rodolfo, additional, Forti, Giacomo, additional, Antonelli, Elisabetta, additional, Bassotti, Gabrio, additional, Iannelli, Chiara, additional, Luzza, Francesco, additional, Aragona, Giovanni, additional, Perazzo, Patrizia, additional, Lauria, Angelo, additional, Piergallini, Simona, additional, Colucci, Raffaele, additional, Bianco, Maria Antonia, additional, Meucci, Costantino, additional, Giorgetti, Gianmarco, additional, Clemente, Valeria, additional, Fiorella, Serafina, additional, Penna, Antonio, additional, De Medici, Antonio, additional, Picchio, Marcello, additional, and Papa, Alfredo, additional

Published
2023
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22. Diagnosis and treatment of faecal incontinence: Consensus statement of the Italian Society of Colorectal Surgery and the Italian Association of Hospital Gastroenterologists

Author

Pucciani, Filippo, Altomare, Donato Francesco, Dodi, Giuseppe, Falletto, Ezio, Frasson, Alvise, Giani, Iacopo, Martellucci, Jacopo, Naldini, Gabriele, Piloni, Vittorio, Sciaudone, Guido, Bove, Antonio, Bocchini, Renato, Bellini, Massimo, Alduini, Pietro, Battaglia, Edda, Galeazzi, Francesca, Rossitti, Piera, and Usai Satta, Paolo

Published
2015
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23. White Paper of Italian Gastroenterology: Delivery of services for digestive diseases in Italy: Weaknesses and strengths

Author

Actis, Giovanni, Adamo, Salvatore, Amitrano, Lucio, Amuso, Mariano, Ancarani, Ornella, Angelico, Mario, Antonini, Filippo, Badiali, Danilo, Balzano, Antonio, Bardella, Maria Teresa, Barresi, Luca, Bellentani, Stefano, Bellini, Massimo, Benedetti, Antonio, Biagini, Massimiliano, Bianchi, Sabrina, Bianco, Antonietta, Borro, Paolo, Bortoli, Aurora, Bortoluzzi, Francesco, Borzio, Mauro, Boskovski, Ivo, Brosolo, Piero, Brunelli, Eugenio, Brunetto, Maurizia, Buri, Luigi, Burra, Patrizia, Caletti, Giancarlo, Chilovi, Fausto, Cicala, Michele, Ciliberto, Enrico, Cilona, Antonio, Cipolletta, Livio, Claar, Giovanni M., Conigliaro, Rita, Conio, Massimo, Corazziari, Enrico, Costamagna, Guido, Cottone, Mario, Craxì, Antonio, Crotta, Sergio, Cucchiara, Salvatore, Cupella, Francesco, Cuppone, Renato, D’Amico, Gennaro, D’Imperio, Nicola, De Angelis, Claudio, De Pretis, Giovanni, De Stefano, Salvatore, Del Favero, Giuseppe, Del Piano, Mario, Di Cillo, Michele, Di Leo, Alfredo, Di Matteo, Giovanni, Ederle, Andrea, Elli, Luca, Fagiuoli, Stefano, Familiari, Luigi, Familiari, Pietro, Fava, Gianmarco, Federici, Telemaco, Ferrini, Giovanni, Filiberti, Rosa, Fracasso, Pierluigi, Framarin, Luciana, Fregonese, Diego, Frosini, Giorgio, Frulloni, Luca, Fusaroli, Pietro, Gallo, Vincenzo, Gatto, Gianni, Gemme, Carlo, Germanà, Bastianello, Germani, Giacomo, Guardascione, Francesco, Gullotta, Renzo, Hassan, Cesare, Ingrosso, Marcello, Kohn, Anna, Lauri, Adriano, Leandro, Gioacchino, Leo, Piero, Lorenzini, Ivano, Loriga, Piero, Macarri, Giampiero, Magnolfi, Fabrizio, Manta, Raffaele, Marchi, Santino, Marin, Renato, Marini, Mario, Marino, Antonino, Meroni, Emanuele, Milazzo, Giuseppe, Monastra, Santo, Montalbano, Luigi, Morini, Sergio, Muscatiello, Nicola, Natali, Alessandro, Neri, Matteo, Nucci, Andrea, Pace, Fabio, Pallone, Francesco, Parodi, Maria Caterina, Pasquale, Luigi, Penagini, Roberto, Peralta, Sergio, Peruzzi, Egiziano, Piazzi, Lucia, Quondamcarlo, Cinzia, Radaelli, Franco, Rendina, Maria, Ridolfi, Francesco, Rosina, Floriano, Salmi, Andrea, Sansoè, Giovanni, Scafato, Emanuele, Scarpulla, Giuseppe, Solinas, Attilio, Soncini, Marco, Sorrentini, Italo, Spinzi, Giancarlo, Stroppa, Italo, Sturniolo, Giancarlo, Sumberaz, Alessandro, Tammaro, Leonardo, Tarantino, Ilaria, Testino, Gianni, Traina, Mario, Triossi, Omero, Usai-Satta, Paolo, Vilardo, Luigi, Virgilio, Clara, Zambelli, Alessandro, Zilli, Maurizio, Zullo, Angelo, Buscarini, Elisabetta, Conte, Dario, Cannizzaro, Renato, Bazzoli, Franco, De Boni, Michele, Delle Fave, Gianfranco, Farinati, Fabio, Ravelli, Paolo, Testoni, Pier Alberto, Lisiero, Manola, and Spolaore, Paolo

Published
2014
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24. Loss-of-Function of the Voltage-Gated Sodium Channel NaV1.5 (Channelopathies) in Patients With Irritable Bowel Syndrome

Author

Beyder, Arthur, Mazzone, Amelia, Strege, Peter R., Tester, David J., Saito, Yuri A., Bernard, Cheryl E., Enders, Felicity T., Ek, Weronica E., Schmidt, Peter T., Dlugosz, Aldona, Lindberg, Greger, Karling, Pontus, Ohlsson, Bodil, Gazouli, Maria, Nardone, Gerardo, Cuomo, Rosario, Usai–Satta, Paolo, Galeazzi, Francesca, Neri, Matteo, Portincasa, Piero, Bellini, Massimo, Barbara, Giovanni, Camilleri, Michael, Locke, G. Richard, III, Talley, Nicholas J., D’Amato, Mauro, Ackerman, Michael J., and Farrugia, Gianrico

Published
2014
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25. Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders

Author

Eijsbouts, Chris, Zheng, Tenghao, Kennedy, Nicholas A., Bonfiglio, Ferdinando, Anderson, Carl A., Moutsianas, Loukas, Holliday, Joanne, Shi, Jingchunzi, Shringarpure, Suyash, Voda, Alexandru-Ioan, Farrugia, Gianrico, Franke, Andre, H��benthal, Matthias, Abecasis, Gon��alo, Zawistowski, Matthew, Skogholt, Anne Heidi, Ness-Jensen, Eivind, Hveem, Kristian, Esko, T��nu, Teder-Laving, Maris, Zhernakova, Alexandra, Camilleri, Michael, Boeckxstaens, Guy, Whorwell, Peter J., Spiller, Robin, McVean, Gil, D���Amato, Mauro, Jostins, Luke, Parkes, Miles, Agee, Michelle, Aslibekyan, Stella, Auton, Adam, Bell, Robert K., Bryc, Katarzyna, Clark, Sarah K., Elson, Sarah L., Fletez-Brant, Kipper, Fontanillas, Pierre, Furlotte, Nicholas A., Gandhi, Pooja M., Heilbron, Karl, Hicks, Barry, Hinds, David A., Huber, Karen E., Jewett, Ethan M., Jiang, Yunxuan, Kleinman, Aaron, Lin, Keng-Han, Litterman, Nadia K., Luff, Marie K., McCreight, Jey C., McIntyre, Matthew H., McManus, Kimberly F., Mountain, Joanna L., Mozaffari, Sahar V., Nandakumar, Priyanka, Noblin, Elizabeth S., Northover, Carrie A. M., O���Connell, Jared, Petrakovitz, Aaron A., Pitts, Steven J., Poznik, G. David, Sathirapongsasuti, J. Fah, Shastri, Anjali J., Shelton, Janie F., Tian, Chao, Tung, Joyce Y., Tunney, Robert J., Vacic, Vladimir, Wang, Xin, Zare, Amir S., Kashyap, Purna, Chang, Lin, Mayer, Emeran, Heitkemper, Margaret, Sayuk, Gregory S., Ringel-Kulka, Tamar, Ringel, Yehuda, Chey, William D., Eswaran, Shanti, Merchant, Juanita L., Shulman, Robert J., Bujanda, Luis, Garcia-Etxebarria, Koldo, Dlugosz, Aldona, Lindberg, Greger, Schmidt, Peter T., Karling, Pontus, Ohlsson, Bodil, Walter, Susanna, Faresj��, ��shild O., Simren, Magnus, Halfvarson, Jonas, Portincasa, Piero, Barbara, Giovanni, Usai-Satta, Paolo, Neri, Matteo, Nardone, Gerardo, Cuomo, Rosario, Galeazzi, Francesca, Bellini, Massimo, Latiano, Anna, Houghton, Lesley, Jonkers, Daisy, Kurilshikov, Alexander, Weersma, Rinse K., Netea, Mihai, Tesarz, Jonas, Gauss, Annika, Goebel-Stengel, Miriam, Andresen, Viola, Frieling, Thomas, Pehl, Christian, Schaefert, Rainer, Niesler, Beate, Lieb, Wolfgang, Hanevik, Kurt, Langeland, Nina, Wensaas, Knut-Arne, Litleskare, Sverre, Gabrielsen, Maiken E., Thomas, Laurent, Thijs, Vincent, Lemmens, Robin, Van Oudenhove, Lukas, Wouters, Mira, Eijsbouts C., Zheng T., Kennedy N.A., Bonfiglio F., Anderson C.A., Moutsianas L., Holliday J., Shi J., Shringarpure S., Agee M., Aslibekyan S., Auton A., Bell R.K., Bryc K., Clark S.K., Elson S.L., Fletez-Brant K., Fontanillas P., Furlotte N.A., Gandhi P.M., Heilbron K., Hicks B., Hinds D.A., Huber K.E., Jewett E.M., Jiang Y., Kleinman A., Lin K.-H., Litterman N.K., Luff M.K., McCreight J.C., McIntyre M.H., McManus K.F., Mountain J.L., Mozaffari S.V., Nandakumar P., Noblin E.S., Northover C.A.M., O'Connell J., Petrakovitz A.A., Pitts S.J., Poznik G.D., Sathirapongsasuti J.F., Shastri A.J., Shelton J.F., Tian C., Tung J.Y., Tunney R.J., Vacic V., Wang X., Zare A.S., Voda A.-I., Kashyap P., Chang L., Mayer E., Heitkemper M., Sayuk G.S., Ringel-Kulka T., Ringel Y., Chey W.D., Eswaran S., Merchant J.L., Shulman R.J., Bujanda L., Garcia-Etxebarria K., Dlugosz A., Lindberg G., Schmidt P.T., Karling P., Ohlsson B., Walter S., Faresjo A.O., Simren M., Halfvarson J., Portincasa P., Barbara G., Usai-Satta P., Neri M., Nardone G., Cuomo R., Galeazzi F., Bellini M., Latiano A., Houghton L., Jonkers D., Kurilshikov A., Weersma R.K., Netea M., Tesarz J., Gauss A., Goebel-Stengel M., Andresen V., Frieling T., Pehl C., Schaefert R., Niesler B., Lieb W., Hanevik K., Langeland N., Wensaas K.-A., Litleskare S., Gabrielsen M.E., Thomas L., Thijs V., Lemmens R., Van Oudenhove L., Wouters M., Farrugia G., Franke A., Hubenthal M., Abecasis G., Zawistowski M., Skogholt A.H., Ness-Jensen E., Hveem K., Esko T., Teder-Laving M., Zhernakova A., Camilleri M., Boeckxstaens G., Whorwell P.J., Spiller R., McVean G., D'Amato M., Jostins L., Parkes M., Eijsbouts, Chris [0000-0001-5179-0653], Anderson, Carl A. [0000-0003-1719-7009], Moutsianas, Loukas [0000-0001-5453-345X], Holliday, Joanne [0000-0003-4568-7320], Shringarpure, Suyash [0000-0001-6464-2668], Voda, Alexandru-Ioan [0000-0003-2974-6992], Farrugia, Gianrico [0000-0003-3473-5235], Hübenthal, Matthias [0000-0002-5956-3006], Abecasis, Gonçalo [0000-0003-1509-1825], Zawistowski, Matthew [0000-0002-3005-083X], Ness-Jensen, Eivind [0000-0001-6005-0729], Teder-Laving, Maris [0000-0002-5872-1850], Camilleri, Michael [0000-0001-6472-7514], Whorwell, Peter J. [0000-0002-5220-8474], Spiller, Robin [0000-0001-6371-4500], McVean, Gil [0000-0002-5012-4162], D’Amato, Mauro [0000-0003-2743-5197], Jostins, Luke [0000-0002-2475-3969], Parkes, Miles [0000-0002-6467-0631], Apollo - University of Cambridge Repository, Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Translational Immunology Groningen (TRIGR), Eijsbouts, C., Zheng, T., Kennedy, N. A., Bonfiglio, F., Anderson, C. A., Moutsianas, L., Holliday, J., Shi, J., Shringarpure, S., Agee, M., Aslibekyan, S., Auton, A., Bell, R. K., Bryc, K., Clark, S. K., Elson, S. L., Fletez-Brant, K., Fontanillas, P., Furlotte, N. A., Gandhi, P. M., Heilbron, K., Hicks, B., Hinds, D. A., Huber, K. E., Jewett, E. M., Jiang, Y., Kleinman, A., Lin, K. -H., Litterman, N. K., Luff, M. K., Mccreight, J. C., Mcintyre, M. H., Mcmanus, K. F., Mountain, J. L., Mozaffari, S. V., Nandakumar, P., Noblin, E. S., Northover, C. A. M., O'Connell, J., Petrakovitz, A. A., Pitts, S. J., Poznik, G. D., Sathirapongsasuti, J. F., Shastri, A. J., Shelton, J. F., Tian, C., Tung, J. Y., Tunney, R. J., Vacic, V., Wang, X., Zare, A. S., Voda, A. -I., Kashyap, P., Chang, L., Mayer, E., Heitkemper, M., Sayuk, G. S., Ringel-Kulka, T., Ringel, Y., Chey, W. D., Eswaran, S., Merchant, J. L., Shulman, R. J., Bujanda, L., Garcia-Etxebarria, K., Dlugosz, A., Lindberg, G., Schmidt, P. T., Karling, P., Ohlsson, B., Walter, S., Faresjo, A. O., Simren, M., Halfvarson, J., Portincasa, P., Barbara, G., Usai-Satta, P., Neri, M., Nardone, G., Cuomo, R., Galeazzi, F., Bellini, M., Latiano, A., Houghton, L., Jonkers, D., Kurilshikov, A., Weersma, R. K., Netea, M., Tesarz, J., Gauss, A., Goebel-Stengel, M., Andresen, V., Frieling, T., Pehl, C., Schaefert, R., Niesler, B., Lieb, W., Hanevik, K., Langeland, N., Wensaas, K. -A., Litleskare, S., Gabrielsen, M. E., Thomas, L., Thijs, V., Lemmens, R., Van Oudenhove, L., Wouters, M., Farrugia, G., Franke, A., Hubenthal, M., Abecasis, G., Zawistowski, M., Skogholt, A. H., Ness-Jensen, E., Hveem, K., Esko, T., Teder-Laving, M., Zhernakova, A., Camilleri, M., Boeckxstaens, G., Whorwell, P. J., Spiller, R., Mcvean, G., D'Amato, M., Jostins, L., and Parkes, M.

Subjects
Male, Molecular Chaperone, Mood Disorder, 631/208/205/2138, Biology, 692/699/1503/1502/2071, Bioinformatics, Polymorphism, Single Nucleotide, Genetic pathways, 38/43, Irritable Bowel Syndrome, Cytoskeletal Protein, Genetics, medicine, Genetic predisposition, Aged, Anxiety Disorders, CD56 Antigen, Cell Adhesion Molecules, Cytoskeletal Proteins, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Guanine Nucleotide Exchange Factors, Homeodomain Proteins, Humans, Middle Aged, Molecular Chaperones, Mood Disorders, United Kingdom, Polymorphism, 692/699/476, Irritable bowel syndrome, Depression (differential diagnoses), article, Homeodomain Protein, Single Nucleotide, Guanine Nucleotide Exchange Factor, medicine.disease, Neuroticism, Biobank, Mood, Cell Adhesion Molecule, Anxiety, medicine.symptom, Anxiety Disorder, Human
Abstract

Funder: Kennedy Trust Rheumatology Research Prize Studentship, Funder: DFG Cluster of Excellence ���Precision Medicine in Chronic In-flammation��� (PMI; ID: EXC2167), Funder: EC | EC Seventh Framework Programm | FP7 Ideas: European Research Council (FP7-IDEAS-ERC - Specific Programme: ���Ideas��� Implementing the Seventh Framework Programme of the European Community for Research, Technological Development and Demonstration Activities (2007 to 2013)); doi: https://doi.org/10.13039/100011199; Grant(s): 715772, Funder: NWO-VIDI grant 016.178.056, the Netherlands Heart Foundation CVON grant 2018-27, and NWO Gravitation grant ExposomeNL, Funder: Li Ka Shing Foundation (Li Ka Shing Foundation Limited); doi: https://doi.org/10.13039/100007421, Irritable bowel syndrome (IBS) results from disordered brain���gut interactions. Identifying susceptibility genes could highlight the underlying pathophysiological mechanisms. We designed a digestive health questionnaire for UK Biobank and combined identified cases with IBS with independent cohorts. We conducted a genome-wide association study with 53,400 cases and 433,201 controls and replicated significant associations in a 23andMe panel (205,252 cases and 1,384,055 controls). Our study identified and confirmed six genetic susceptibility loci for IBS. Implicated genes included NCAM1, CADM2, PHF2/FAM120A, DOCK9, CKAP2/TPTE2P3 and BAG6. The first four are associated with mood and anxiety disorders, expressed in the nervous system, or both. Mirroring this, we also found strong genome-wide correlation between the risk of IBS and anxiety, neuroticism and depression (rg > 0.5). Additional analyses suggested this arises due to shared pathogenic pathways rather than, for example, anxiety causing abdominal symptoms. Implicated mechanisms require further exploration to help understand the altered brain���gut interactions underlying IBS.

Published
2021
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26. Prevalence of Endoscopic and Histological Lesions at Upper Endoscopy: A Cross-Sectional, Multicentre Study in Clinical Practice

Author

De Francesco, Vincenzo, Zullo, Angelo, Amato, Arnaldo, Bergna, Irene, Bendia, Emanuele, Giorgini, Giorgia, Buscarini, Elisabetta, Manfredi, Guido, Cadoni, Sergio, Cannizzaro, Renato, Realdon, Stefano, Ciuffi, Mario, Ignomirelli, Orazio, Da Massa Carrara, Paola, Finucci, Giovanni, Di Somma, Antonietta, Frandina, Chiara, Loria, Mariafrancesca, Galeazzi, Francesca, Ferrara, Francesco, Gemme, Carlo, Bertetti, Noemi Sara, Gentili, Federica, Lotito, Antonio, Germanà, Bastianello, Russo, Nunzia, Grande, Giuseppe, Conigliaro, Rita, Cravero, Federico, Venezia, Giovanna, Marmo, Riccardo, Senneca, Piera, Milano, Angelo, Efthymakis, Konstantinos, Monica, Fabio, Montalto, Paolo, Lombardi, Mario, Morelli, Olivia, Castellani, Danilo, Nigro, Daniela, Festa, Roberto, Peralta, Sergio, Grasso, Maria, Privitera, Antonino Carlo, Di Stefano, Maria Emanuela, Scaccianoce, Giuseppe, Loiacono, Mariangela, Segato, Sergio, Balzarini, Marco, Usai Satta, Paolo, Lai, Mariantonia, and Manta, Raffaele

Abstract

Background/Aim:Prevalence of gastroduodenal endoscopic and histological lesions may modify over time due to different factors. We assessed both macroscopic and histological lesions currently detected at upper endoscopy performed in routine practice. Patients and Methods:Clinical, endoscopic, and histological data of consecutive adult patients referred for upper endoscopy in the 28 participating centres were analysed. Only patients who underwent the first endoscopic examination were considered. Prevalence of erosive/ulcerative lesions, cancers and extensive precancerous lesions in the stomach, and Helicobacter pyloriinfection was computed. Results:A total of 1,431 patients underwent endoscopy for gastro-oesophageal reflux symptoms (31.5%), dyspepsia (29.4%), or alarm symptoms (18.5%). Erosive oesophagitis or Barrett’s oesophagus was detected in 210 (14.7%) cases, peptic ulcer in 49 (3.4%), and a neoplastic lesion in 17 (1.2%). H. pyloriwas present in 201 (22.6%) cases, and extensive precancerous lesions on gastric mucosa in 46 (5.6%) patients. Gastric lesions were more prevalent in patients aged ≥50 years (26% vs. 18%; p= 0.001), and peptic ulcers were more frequently detected in patients with H. pylori(9.4% vs. 2.3%; p= 0.001) and in males (5.8% vs. 1.6%; p= 0.001), while neoplastic lesions in patients with alarm symptoms (3.8% vs. 0.6%; p= 0.001). Conclusions:The overall endoscopic lesions were more prevalent in patients aged ≥50 years, peptic ulcer and erosions were more frequent in H. pylori-infected patients, and extensive gastric precancerous lesions were present in less than 6% of cases.

Published
2024
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29. Functional variants in the sucrase–isomaltase gene associate with increased risk of irritable bowel syndrome

Author

Henström, Maria, Diekmann, Lena, Bonfiglio, Ferdinando, Hadizadeh, Fatemeh, Kuech, Eva-Maria, von Köckritz-Blickwede, Maren, Thingholm, Louise B, Zheng, Tenghao, Assadi, Ghazaleh, Dierks, Claudia, Heine, Martin, Philipp, Ute, Distl, Ottmar, Money, Mary E, Belheouane, Meriem, Heinsen, Femke-Anouska, Rafter, Joseph, Nardone, Gerardo, Cuomo, Rosario, Usai-Satta, Paolo, Galeazzi, Francesca, Neri, Matteo, Walter, Susanna, Simrén, Magnus, Karling, Pontus, Ohlsson, Bodil, Schmidt, Peter T, Lindberg, Greger, Dlugosz, Aldona, Agreus, Lars, Andreasson, Anna, Mayer, Emeran, Baines, John F, Engstrand, Lars, Portincasa, Piero, Bellini, Massimo, Stanghellini, Vincenzo, Barbara, Giovanni, Chang, Lin, Camilleri, Michael, Franke, Andre, Naim, Hassan Y, and DʼAmato, Mauro

Published
2018
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31. Translational Gap between Guidelines and Clinical Medicine: The Viewpoint of Italian General Practitioners in the Management of IBS

Author

Bellini, Massimo, primary, Tosetti, Cesare, additional, Rettura, Francesco, additional, Morganti, Riccardo, additional, Lambiase, Christian, additional, Bassotti, Gabrio, additional, Visaggi, Pierfrancesco, additional, Pancetti, Andrea, additional, Benedetto, Edoardo, additional, de Bortoli, Nicola, additional, Usai-Satta, Paolo, additional, and De Bastiani, Rudi, additional

Published
2022
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34. Chronic Idiopathic Constipation in Adults: A Review on Current Guidelines and Emerging Treatment Options

Author

Bassotti,Gabrio, Usai Satta,Paolo, and Bellini,Massimo

Subjects
Clinical and Experimental Gastroenterology
Abstract

Gabrio Bassotti,1 Paolo Usai Satta,2 Massimo Bellini3 1Gastroenterology & Hepatology Section, Department of Medicine and Surgery, University of Perugia, Perugia, Italy; 2Gastrointestinal Unit, “G. Brotzu” Hospital, Cagliari, Italy; 3Gastrointestinal Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, ItalyCorrespondence: Gabrio BassottiClinica di Gastroenterologia ed Epatologia, Ospedale Santa Maria della Misericordia, Piazzale Menghini, 1, San Sisto (Perugia), 06156, ItalyEmail gabassot@tin.itAbstract: Chronic idiopathic constipation (CIC) is a common functional bowel disorder characterized by difficult, infrequent, and/or incomplete defecation. It has a great impact on the quality of life and on health care system and represents a heavy economic burden. The diagnosis is based on symptoms, classified by the Rome IV criteria. The aim of this review was to evaluate the current therapeutic guidelines for adult CIC and highlight new emerging treatments. In detail, European, French, Spanish and Korean guidelines have been identified and compared. Osmotic laxatives, and in particular polyethylene glycol, represent the first-line therapeutic approach. Stimulant laxatives are recommended as a second-line therapy. Pelvic floor rehabilitation is recommended in patients with ano-rectal dyssynergia. In patients who fail to improve with pharmacological therapies sacral nerve stimulation is considered as last chance before surgery. Surgical approach has however limited indications in selected cases. Inertia coli refractory to any approach and obstructed defecation are two subtypes which can benefit from surgery. Among emerging agents, prucalopride, a prokinetic agent, is recommended as a second-line treatment in refractory CIC patients. In addition, the secretagogues linaclotide and plecanatide and the bile acid transported inhibitor elobixibat can be effective in patients not responsive to a second-line therapeutic regimen, although they are not worldwide commercially available.Keywords: chronic idiopathic constipation, guidelines, osmotic laxatives, pelvic floor rehabilitation, prokinetics, secretagogues

Published
2021

37. Advance in Gluten-Free Diet

Author

Usai-Satta Paolo

Subjects
chemistry.chemical_classification, Nickel allergy, Dietary iron, medicine.medical_specialty, business.industry, Low nickel diet, medicine.disease, Gluten, Gastroenterology, chemistry, Dietary Reference Intake, Internal medicine, Medicine, Gluten free, business, FODMAP, Irritable bowel syndrome
Published
2021
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38. Changes in digestive cancer diagnosis during the SARS-CoV-2 pandemic in Italy: A nationwide survey

Author

Buscarini, Elisabetta, primary, Benedetti, Antonio, additional, Monica, Fabio, additional, Pasquale, Luigi, additional, Buttitta, Francesco, additional, Cameletti, Michela, additional, Ferrari, Clarissa, additional, Ricciardiello, Luigi, additional, Massironi, Sara, additional, Bianco, Maria Antonia, additional, Germanà, Bastianello, additional, Rodinò, Stefano, additional, Anderloni, Andrea, additional, Mussetto, Alessandro, additional, Nipote, Bruno, additional, Russo, Salvatore, additional, Manta, Raffaele, additional, Lauri, Adriano, additional, Occhipinti, Vincenzo, additional, Marco, Marco Di, additional, Giovannone, Maurizio, additional, Binda, Cecilia, additional, Sbrancia, Monica, additional, Paolo, Maria Carla Di, additional, de’-Angelis, Gian Luigi, additional, Fiori, Giancarla, additional, Dal-Fante, Marco, additional, Caro, Giuseppe de, additional, Usai-Satta, Paolo, additional, Cesarini, Monica, additional, Piras, Enrico, additional, Stasi, Elisa, additional, Serio, Giovanni, additional, Montalbano, Luigi Maria, additional, Mirante, Vincenzo Giorgio, additional, Burattini, Osvaldo, additional, Attardo, Simona, additional, Bargiggia, Stefano, additional, Dinca, Manuele, additional, Missale, Guido, additional, Alvisi, Costanza, additional, Broglia, Francesco, additional, Ferraris, Luca, additional, Conti-Bellocchi, Maria Cristina, additional, Luigiano, Carmelo, additional, Pallio, Socrate, additional, Brunacci, Matteo, additional, Manfrini, Carlo, additional, Bozzi, Rosamaria, additional, Checchin, Davide, additional, Togliani, Thomas, additional, D'errico, Antonietta, additional, Bazzoli, Franco, additional, La Bianca, Orazio, additional, Berretti, Debora, additional, and Alvaro, Domenico, additional

Published
2021
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44. Editorial: symptom improvement does not equal satisfaction with treatment for constipation-authors’ reply

Author

Basilisco, Guido, primary, Barbara, Giovanni, additional, Bellini, Massimo, additional, Cataudella, Giovanni, additional, D’Alba, Lucia, additional, Guarino, Michele, additional, Iovino, Paola, additional, Neri, Maria Cristina, additional, Sarnelli, Giovanni, additional, Savarino, Edoardo, additional, Tolone, Salvatore, additional, Torresan, Francesco, additional, Usai-Satta, Paolo, additional, Lovati, Ambra, additional, Arsiè, Elena, additional, and Coletta, Marina, additional

Published
2020
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46. IBS clinical management in Italy: The AIGO survey

Author

Soncini, Marco, primary, Stasi, Cristina, additional, Usai Satta, Paolo, additional, Milazzo, Giuseppe, additional, Bianco, Margherita, additional, Leandro, Gioacchino, additional, Montalbano, Luigi Maria, additional, Muscatiello, Nicola, additional, Monica, Fabio, additional, Galeazzi, Francesca, additional, Bellini, Massimo, additional, Carrara, Maurizio, additional, Cabras, Francesco, additional, Guerra, Vito, additional, Camilleri, Salvatore, additional, Gambaccini, Dario, additional, Tammaro, Leonardo, additional, D’Alba, Lucia, additional, Turco, Luigi, additional, Gasparini, Paolo, additional, Solinas, Attilio, additional, Russo, Giovanni, additional, Pancetti, Andrea, additional, Salvioli, Beatrice, additional, Anderloni, Andrea, additional, Bassotti, Gabrio, additional, Lai, Maria Antonia, additional, Antonino, Matteo, additional, De Bona, Manuela, additional, Boschetto, Sandro, additional, Rentini, Silvia, additional, Rossitti, Piera, additional, Limido, Eugenio, additional, and Balzano, Antonio, additional

Published
2019
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47. Su1649 – Why Patients with Chronic Constipation Or Irritable Bowel Syndrome with Constipation are Not Satisfied with Therapy?

Author

Basilisco, Guido, primary, Barbara, Giovanni, additional, Bellini, Massimo, additional, Cataudella, Giovanni, additional, D’Alba, Lucia, additional, Guarino, Michele Pier Luca, additional, Iovino, Paola, additional, Neri, Maria C., additional, Sarnelli, Giovanni, additional, Savarino, Edoardo V., additional, Tolone, Salvatore, additional, Torresan, Francesco, additional, Usai-Satta, Paolo, additional, Lovati, Ambra E., additional, Arsiè, Elena, additional, and Coletta, Marina, additional

Published
2019
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48. Chronic constipation diagnosis and treatment evaluation: the 'CHRO.CO.DI.T.E.' study

Author

Bellini, Massimo, Usai-Satta, Paolo, Bove, Antonio, Bocchini, Renato, Galeazzi, Francesca, Battaglia, Edda, Alduini, Pietro, Buscarini, Elisabetta, Bassotti, Gabrio, Balzano, Antonio, Portincasa, Piero, Bonfrate, Leonilde, D'Alba, Lucia, Badiali, Danilo, Marchi, Santino, Gambaccini, Dario, Neri, Maria Cristina, Muscatiello, Nicola, Di Stefano, Michele, Giannelli, Claudio, Goffredo, Fabio, Turco, Luigi, Camilleri, Salvatore, Ceccarelli, Giovanni, Iovino, Paola, Montalbano, Luigi Maria, Morreale, Gaetano Cristian, Rentini, Silvia, Savarino, Vincenzo, Segato, Sergio, Manfredi, Guido, Cannizzaro, Renato, Passaretti, Sandro, Alessandri, Matteo, Corti, Federico, Cuomo, Rosario, Zito, Francesco Paolo, Mellone, Carmine, Barbera, Roberta, Milazzo, Giuseppe, Pucciani, Filippo, Soncini, Marco, Lai, Maria Antonia, Ruggeri, Maurizio, Savarese, Maria Flavia, De Bona, Manuela, Surrenti, Elisabetta, Arini, Andrea, Dinelli, Marco, Leandro, Gioacchino, Peralta, Sergio, Manta, Raffaele, Quartini, Mariano, Torresan, Francesco, Vilardo, Luigi, Pulvirenti D'Urso, Antonino, Tarantino, Ottaviano, Noris, Roberto Antonio, Monica, Fabio, Carrara, Maurizio, Losco, Alessandra, Lauri, Adriano, Neri, Matteo, Grassini, Mario, Bellini, Massimo, Usai Satta, Paolo, Bove, Antonio, Bocchini, Renato, Battaglia, Edda, Alduini, P, Bassotti, Gabrio, Balzano, Antonio, Portincasa, Piero, Bonfrate, L, D'Alba, L, Badiali, Danilo, Marchi, Santino, Gambaccini, D, Neri, Mc, Muscatiello, N, Di Stefano, M, Giannelli, C, Goffredo, F, Turco, L, Camilleri, S, Ceccarelli, G, Iovino, Paola, Montalbano, Lm, Morreale, G, Rentini, S, Savarino, Vincenzo, Segato, S, Buscarini, E, Manfredi, G, Cannizzaro, Renato, Passaretti, S, Alessandri, M, Corti, F, Cuomo, Rosario, Zito, FRANCESCO PAOLO, Mellone, C, Barbera, Roberta, Milazzo, G, Pucciani, F, Marco, S, Lai, Ma, Ruggeri, M, Savarese, Mf, De Bona, M, Surrenti, E, Arini, A, Dinelli, M, Leandro, G, Peralta, S, Manta, Raffaele, Quartini, M, Torresan, F, Vilardo, L, Pulvirenti D'Urso, A, Tarantino, O, Noris, Ra, Monica, F, Carrara, M, Losco, A, Lauri, A, and Neri, M.

Subjects
Adult, Male, medicine.medical_specialty, Constipation, Diet therapy, Colonoscopy, Gastroenterology, Severity of Illness Index, Irritable Bowel Syndrome, 03 medical and health sciences, Diagnosis, Functional constipation, Irritable bowel syndrome, Treatment, Aged, Chronic Disease, Defecography, Digital Rectal Examination, Female, Humans, Italy, Middle Aged, Surveys and Questionnaires, Symptom Assessment, 0302 clinical medicine, Internal medicine, medicine, Gastrointestinal agent, Chronic constipation, Prucalopride, medicine.diagnostic_test, business.industry, General Medicine, medicine.disease, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, medicine.symptom, business, Diagnosi, medicine.drug, Research Article
Abstract

Background According to Rome criteria, chronic constipation (CC) includes functional constipation (FC) and irritable bowel syndrome with constipation (IBS-C). Some patients do not meet these criteria (No Rome Constipation, NRC). The aim of the study was is to evaluate the various clinical presentation and management of FC, IBS-C and NRC in Italy. Methods During a 2-month period, 52 Italian gastroenterologists recorded clinical data of FC, IBS-C and NRC patients, using Bristol scale, PAC-SYM and PAC-QoL questionnaires. In addition, gastroenterologists were also asked to record whether the patients were clinically assessed for CC for the first time or were in follow up. Diagnostic tests and prescribed therapies were also recorded. Results Eight hundred seventy-eight consecutive CC patients (706 F) were enrolled (FC 62.5%, IBS-C 31.3%, NRC 6.2%). PAC-SYM and PAC-QoL scores were higher in IBS-C than in FC and NRC. 49.5% were at their first gastroenterological evaluation for CC. In 48.5% CC duration was longer than 10 years. A specialist consultation was requested in 31.6%, more frequently in IBS-C than in NRC. Digital rectal examination was performed in only 56.4%. Diagnostic tests were prescribed to 80.0%. Faecal calprotectin, thyroid tests, celiac serology, breath tests were more frequently suggested in IBS-C and anorectal manometry in FC. More than 90% had at least one treatment suggested on chronic constipation, most frequently dietary changes, macrogol and fibers. Antispasmodics and psychotherapy were more frequently prescribed in IBS-C, prucalopride and pelvic floor rehabilitation in FC. Conclusions Patients with IBS-C reported more severe symptoms and worse quality of life than FC and NRC. Digital rectal examination was often not performed but at least one diagnostic test was prescribed to most patients. Colonoscopy and blood tests were the “first line” diagnostic tools. Macrogol was the most prescribed laxative, and prucalopride and pelvic floor rehabilitation represented a “second line” approach. Diagnostic tests and prescribed therapies increased by increasing CC severity. Electronic supplementary material The online version of this article (doi:10.1186/s12876-016-0556-7) contains supplementary material, which is available to authorized users.

Published
2017

49. Bloating is associated with worse quality of life, treatment satisfaction, and treatment responsiveness among patients with constipation-predominant irritable bowel syndrome and functional constipation

Author

Neri, L., Iovino, P., Altomare, Donato Francesco, Annese, Vito, Badiali, Danilo, Basilisco, Guido, Bassotti, Gabrio, Battaglia, Edda, Bazzocchi, Gabriele, Bellini, Massimo, Bendia, Emanuele, Benini, Luigi, Biscaglia, Giuseppe, Biviano, Ivano, Bocchini, Renato, Bonventre, Sebastiano, Bossa, Fabrizio, Brandimarte, Giovanni, Cannizzaro, Renato, Cicala, Michele, Cipolletta, Livio, Clara, Virgilio, Cogliandro, Rosanna, Comandini, Giulia, Corazziari, Enrico, Crotta, Sergio, Cuomo, Rosario, D'Alba, Lucia, De Giorgi, Francesco, Del Piano, Mario, Di Fonzo, Michela, Di Mario, Francesco, Di Stefano, Michele, D'Onofrio, Vittorio, Efthymakis, Kostantinos, Fiore, Pierluigi, Fortuna, Manuela, Fries, Walter, Gaetani, Eleonora, Galeazzi, Francesca, Gasbarrini, Antonio, Geccherle, Andrea, Giangregorio, Francesco, Girardi, Lisa, Grassini, Mario, Groppo, Marzia, Guarnieri, Giovanni, Lo Cascio, Massimiliano, Lolli, Roberto, Luzza, Francesco, Macarri, Giampiero, Marino, Maria, Miraglia, Stefania, Monastra, Santo, Neri, Maria Cristina, Neri, Matteo, Noris, Roberto Antonio, Orselli, Silvia, Passaretti, Sandro, Paviotti, Alberto, Pazzi, Paolo, Pilotto, Alberto, Portincasa, Piero, Ranaldo, Nunzio, Ravelli, Paolo, Rogai, Francesca, Sablich, Renato, Savarino, Vincenzo, Spinzi, Giancarlo, Stanghellini, Vincenzo, Tammaro, Leonardo, Torresan, Francesco, Usai Satta, Paolo, Valle, C. Claudio, Neri, L., Iovino, P., Altomare, Donato Francesco, Annese, Vito, Badiali, Danilo, Basilisco, Guido, Bassotti, Gabrio, Battaglia, Edda, Bazzocchi, Gabriele, Bellini, Massimo, Bendia, Emanuele, Benini, Luigi, Biscaglia, Giuseppe, Biviano, Ivano, Bocchini, Renato, Bonventre, Sebastiano, Bossa, Fabrizio, Brandimarte, Giovanni, Cannizzaro, Renato, Cicala, Michele, Cipolletta, Livio, Clara, Virgilio, Cogliandro, Rosanna, Comandini, Giulia, Corazziari, Enrico, Crotta, Sergio, Cuomo, Rosario, D'Alba, Lucia, De Giorgi, Francesco, Del Piano, Mario, Di Fonzo, Michela, Di Mario, Francesco, Di Stefano, Michele, D'Onofrio, Vittorio, Efthymakis, Kostantino, Fiore, Pierluigi, Fortuna, Manuela, Fries, Walter, Gaetani, Eleonora, Galeazzi, Francesca, Gasbarrini, Antonio, Geccherle, Andrea, Giangregorio, Francesco, Girardi, Lisa, Grassini, Mario, Groppo, Marzia, Guarnieri, Giovanni, Lo Cascio, Massimiliano, Lolli, Roberto, Luzza, Francesco, Macarri, Giampiero, Marino, Maria, Miraglia, Stefania, Monastra, Santo, Neri, Maria Cristina, Neri, Matteo, Noris, Roberto Antonio, Orselli, Silvia, Passaretti, Sandro, Paviotti, Alberto, Pazzi, Paolo, Pilotto, Alberto, Portincasa, Piero, Ranaldo, Nunzio, Ravelli, Paolo, Rogai, Francesca, Sablich, Renato, Savarino, Vincenzo, Spinzi, Giancarlo, Stanghellini, Vincenzo, Tammaro, Leonardo, Torresan, Francesco, Usai Satta, Paolo, Valle, C. Claudio, Altomare, D., Annese, V., Badiali, D., Basilisco, G., Bassotti, G., Battaglia, E., Bazzocchi, G., Bellini, M., Bendia, E., Benini, L., Biscaglia, G., Biviano, I., Bocchini, R., Bonventre, S., Bossa, F., Brandimarte, G., Cannizzaro, R., Cicala, M., Cipolletta, L., Clara, V., Cogliandro, R., Comandini, G., Corazziari, E., Crotta, S., Cuomo, R., D'Alba, L., De Giorgi, F., Del Piano, M., Di Fonzo, M., Di Mario, F., Di Stefano, M., D'Onofrio, V., Efthymakis, K., Fiore, P., Fortuna, M., Fries, W., Gaetani, E., Galeazzi, F., Gasbarrini, A., Geccherle, A., Giangregorio, F., Girardi, L., Grassini, M., Groppo, M., Guarnieri, G., Lo Cascio, M., Lolli, R., Luzza, F., Macarri, G., Marino, M., Miraglia, S., Monastra, S., Neri, M., Noris, R., Orselli, S., Passaretti, S., Paviotti, A., Pazzi, P., Pilotto, A., Portincasa, P., Ranaldo, N., Ravelli, P., Rogai, F., Sablich, R., Savarino, V., Spinzi, G., Stanghellini, V., Tammaro, L., Torresan, F., Usai Satta, P., and Valle, C.

Subjects
Adult, Male, Quality of life, medicine.medical_specialty, Constipation, Cross-sectional study, Physiology, Bloating, Chronic constipation, Functional constipation, Irritable bowel syndrome, Patient-reported outcomes, Treatment satisfaction, Endocrine and Autonomic Systems, Gastroenterology, Cross-Sectional Studies, Female, Flatulence, Humans, Irritable Bowel Syndrome, Middle Aged, Prevalence, Quality of Life, Surveys and Questionnaires, Endocrine and Autonomic System, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Patient-reported outcome, Settore MED/12 - Gastroenterologia, business.industry, Settore MED/09 - MEDICINA INTERNA, medicine.disease, Settore MED/18 - Chirurgia Generale, Tolerability, 030220 oncology & carcinogenesis, Physical therapy, 030211 gastroenterology & hepatology, medicine.symptom, business
Abstract

Background The management of bloating is unclear and its relationship with patients' well-being and treatment satisfaction independent of other abdominal symptoms is uncharacterized. We evaluated the association of bloating with patient-reported outcomes. Methods Thirty-nine centers for functional gastrointestinal disorders joined the laxative inadequate relief survey. We enrolled 2203 consecutive outpatients with functional constipation (FC) or constipation-predominant irritable bowel syndrome (IBS-C) in two cross-sectional waves. Both wave 1 and 2 included the SF-12, the patient assessment of constipation-symptoms (PAC-SYM), and the treatment satisfaction questionnaire for medication (TSQM-2). Wave 2 only included a global rating of change (GRC) scale to assess patients' assessment of efficacy concerning treatment switches occurred in the 3 months prior to the interview. Bloating in the abdomen was defined on the basis of PAC-SYM item 3. Key Results The average age was 50.1 years (SD, 16.7) and 82.1% of patients were women. The prevalence of bloating was 91.6% (n = 1970). Bloating was associated with SF-12 Physical Composite Score (p < 0.01), SF-12 Mental Composite Score (p < 0.01), GRC (p < 0.01), Satisfaction with treatment effectiveness (p < 0.01), convenience of administration (p < 0.01), and side effects (p < 0.01) after adjustment for possible confounders. Conclusions & Inferences Our data suggest that patients regard bloating as a key element in assessing clinical changes and treatments' efficacy as this symptom exerts a strong influence on patient-reported outcomes independent of possible confounders and other symptoms of constipation. Our data provide the rationale to investigate the efficacy and tolerability of new treatments specifically addressing this important, yet disregarded, patients' complain.

Published
2016

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