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22 results on '"Urnauer, Sarah"'

7. Effective control of tumor growth through spatial and temporal control of theranostic sodium iodide symporter (NIS) gene expression using a heat-inducible gene promoter in engineered mesenchymal stem cells

Author

Tutter, Mariella, primary, Schug, Christina, additional, Schmohl, Kathrin A., additional, Urnauer, Sarah, additional, Schwenk, Nathalie, additional, Petrini, Matteo, additional, Lokerse, Wouter J. M., additional, Zach, Christian, additional, Ziegler, Sibylle, additional, Bartenstein, Peter, additional, Weber, Wolfgang A., additional, Wagner, Ernst, additional, Lindner, Lars H., additional, Nelson, Peter J., additional, and Spitzweg, Christine, additional

Published
2020
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9. TGFB1-driven mesenchymal stem cell-mediated NIS gene transfer

Author

Schug, Christina, primary, Urnauer, Sarah, additional, Jaeckel, Carsten, additional, Schmohl, Kathrin A, additional, Tutter, Mariella, additional, Steiger, Katja, additional, Schwenk, Nathalie, additional, Schwaiger, Markus, additional, Wagner, Ernst, additional, Nelson, Peter J, additional, and Spitzweg, Christine, additional

Published
2019
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10. A Novel Approach for Image-Guided 131I Therapy of Pancreatic Ductal Adenocarcinoma Using Mesenchymal Stem Cell-Mediated NIS Gene Delivery

Author

Schug, Christina, primary, Gupta, Aayush, additional, Urnauer, Sarah, additional, Steiger, Katja, additional, Cheung, Phyllis Fung-Yi, additional, Neander, Christian, additional, Savvatakis, Konstantinos, additional, Schmohl, Kathrin A., additional, Trajkovic-Arsic, Marija, additional, Schwenk, Nathalie, additional, Schwaiger, Markus, additional, Nelson, Peter J., additional, Siveke, Jens T., additional, and Spitzweg, Christine, additional

Published
2019
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11. External Beam Radiation Therapy Enhances Mesenchymal Stem Cell–Mediated Sodium–Iodide Symporter Gene Delivery

Author

Schug, Christina, primary, Sievert, Wolfgang, additional, Urnauer, Sarah, additional, Müller, Andrea M., additional, Schmohl, Kathrin A., additional, Wechselberger, Alexandra, additional, Schwenk, Nathalie, additional, Lauber, Kirsten, additional, Schwaiger, Markus, additional, Multhoff, Gabriele, additional, Wagner, Ernst, additional, Nelson, Peter J., additional, and Spitzweg, Christine, additional

Published
2018
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13. EGFR-targeted nonviral NIS gene transfer for bioimaging and therapy of disseminated colon cancer metastases

Author

Urnauer, Sarah, primary, Müller, Andrea M., additional, Schug, Christina, additional, Schmohl, Kathrin A., additional, Tutter, Mariella, additional, Schwenk, Nathalie, additional, Rödl, Wolfgang, additional, Morys, Stephan, additional, Ingrisch, Michael, additional, Bertram, Jens, additional, Bartenstein, Peter, additional, Clevert, Dirk-André, additional, Wagner, Ernst, additional, and Spitzweg, Christine, additional

Published
2017
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15. Systemic tumor-targeted sodium iodide symporter (NIS) gene therapy of hepatocellular carcinoma mediated by B6 peptide polyplexes

Author

Urnauer, Sarah, primary, Klutz, Kathrin, additional, Grünwald, Geoffrey K., additional, Morys, Stephan, additional, Schwenk, Nathalie, additional, Zach, Christian, additional, Gildehaus, Franz-Josef, additional, Rödl, Wolfgang, additional, Ogris, Manfred, additional, Wagner, Ernst, additional, and Spitzweg, Christine, additional

Published
2017
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17. Hypoxia-targeted 131I therapy of hepatocellular cancer after systemic mesenchymal stem cell-mediated sodium iodide symporter gene delivery

Author

Müller, Andrea M., primary, Schmohl, Kathrin A., additional, Knoop, Kerstin, additional, Schug, Christina, additional, Urnauer, Sarah, additional, Hagenhoff, Anna, additional, Clevert, Dirk-André, additional, Ingrisch, Michael, additional, Niess, Hanno, additional, Carlsen, Janette, additional, Zach, Christian, additional, Wagner, Ernst, additional, Bartenstein, Peter, additional, Nelson, Peter J., additional, and Spitzweg, Christine, additional

Published
2016
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19. Sequence defined cMET/HGFR-targeted polymers as gene delivery vehicles for the theranostic sodium iodide symporter (NIS) gene

Author

Urnauer, Sarah, primary, Morys, Stephan, additional, Levacic, Ana Krhac, additional, Muller, Andrea M, additional, Schug, Christina, additional, Schmohl, Kathrin A, additional, Schwenk, Nathalie, additional, Zach, Christian, additional, Carlsen, Janette, additional, Bartenstein, Peter, additional, Wagner, Ernst, additional, and Spitzweg, Christine, additional

Published
2016
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22. A Novel Approach for Image-Guided 131 I Therapy of Pancreatic Ductal Adenocarcinoma Using Mesenchymal Stem Cell-Mediated NIS Gene Delivery.

Author

Schug C, Gupta A, Urnauer S, Steiger K, Cheung PF, Neander C, Savvatakis K, Schmohl KA, Trajkovic-Arsic M, Schwenk N, Schwaiger M, Nelson PJ, Siveke JT, and Spitzweg C

Subjects
Animals, Carcinoma, Pancreatic Ductal pathology, Carcinoma, Pancreatic Ductal radiotherapy, Cell Line, Cell Line, Tumor, Female, Humans, Male, Mesenchymal Stem Cells cytology, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Pancreatic Neoplasms pathology, Pancreatic Neoplasms radiotherapy, Positron-Emission Tomography methods, Transfection, Carcinoma, Pancreatic Ductal diagnostic imaging, Carcinoma, Pancreatic Ductal therapy, Gene Transfer Techniques, Iodine Radioisotopes administration & dosage, Mesenchymal Stem Cell Transplantation methods, Mesenchymal Stem Cells physiology, Pancreatic Neoplasms diagnostic imaging, Pancreatic Neoplasms therapy
Abstract

The sodium iodide symporter ( SLC5A5/NIS ) as theranostic gene would allow for non-invasive imaging of functional NIS expression and therapeutic radioiodine application. Genetically engineered mesenchymal stem cells (MSC), based on their tumor-homing abilities, show great promise as tumor-selective NIS gene delivery vehicles for non-thyroidal tumors. As a next step towards clinical application, tumor specificity and efficacy of MSCs were investigated in an advanced genetically engineered mouse model of pancreatic ductal adenocarcinoma (PDAC). Syngeneic murine MSCs were stably transfected with a NIS -expressing plasmid driven by the CMV -promoter (NIS-MSC). In vivo 123 I-scintigraphy and 124 I-PET revealed significant perchlorate-sensitive NIS-mediated radioiodide accumulation in PDAC after systemic injection of NIS-MSCs. Active MSC recruitment into the tumor stroma was confirmed using NIS immunohistochemistry (IHC). A therapeutic strategy, consisting of three cycles of systemic MSC-mediated NIS delivery, followed by 131 I application, resulted in a significant delay and reduction in tumor growth as compared to controls. Furthermore, IHC analysis of α-SMA and Ki67 revealed differences in the amount and behavior of activated fibroblasts in tumors of mice injected with NIS-MSCs as compared with saline-treated mice. Taken together, MSCs as NIS gene delivery vehicles in this advanced endogenous PDAC mouse model demonstrated high stromal targeting of NIS by selective recruitment of NIS-MSCs after systemic application resulting in an impressive 131 I therapeutic effect. IMPLICATIONS: These data expand the prospect of MSC-mediated radioiodine imaging-guided therapy of pancreatic cancer using the sodium iodide symporter as a theranostic gene in a clinical setting., (©2018 American Association for Cancer Research.)

Published
2019
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