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Introduction: The widespread use of sevoflurane as an induction and maintenance volatile agent of general anesthesia demostrates an increased safety profile. Sevoflurane contact with CO2 absorbents lead to the occurrence of toxic compounds such as Compund A and Compound B. Among the side efffects of Sevoflurane remember the renal toxic effect much discussed in the literature but still unresolved. In previous research we have demonstrated the glomerular protein changes as a result of exposure to Sevoflurane. In the current study we intend to monitor the changes in blood urea nitrogen and serum creatinine after exposure to Sevoflurane. Material and method: We included in our study 90 patients who were anesthetized in the Department of Anesthesiology of the County Mure Hospital during 01.10.2009-01.10.2014. They had normal values for blood urea nitrogen and serum creatinine and had no preoperative proteinuria. Serum and urine samples were taken preoperatively and at 24 and 72 hours postanesthetic and were analyzed in the laboratory. Proteinuria was determined by spectrophotometry. Results: After protein quantitative determination by spectrophotometry and statistical anaysis we obtained significant differences by comparing the average preoperative/24 hours total protein (p Conclusions: Changes in glomerular filtered proteins following exposure to Sevoflurane demonstrate its toxic effect on glomerular tubules. Lack of perioperative significant wich is why we recommend determining perioperative urinary protein as a marker of glomerular damage.

Twenty clinically healthy goats were divided into two equal groups based on two different diets. Goats in group A were fed with 25 % barley, 12 % oat, 15 % faba bean, 10 % pea, 20 % sugar beet pulps, 5 % molasses and 3 % mineral. Goats in group B were fed with 25 % corn, 15 % soybean hulls, 12 % soybean meal, 10 % sunflower meal, 20 % sugar beet pulps, 5 % molasses and 3 % mineral. To establish the effect of diet composition on haematological and biochemical concentrations, blood samples were collected from the external jugular vein once a week, for 1 month (T0–T4), twice daily (0700 and 1800 hours). Multivariate analysis of variance (MANOVA) showed a significant effect of different diets (P

MR Bacci,1 FT Russo,1 GD Carvalho,1 EZ Chehter,2 VC Jordao,1 FL Fonseca1 1Department of General Practice, 2Department of Gastroenterology, Faculdade de Medicina do ABC (ABC Medical School), Santo André, Brazil Introduction: Although the association between chronic kidney disease and dyspepsia is widely known, it remains poorly investigated. Among the types of gastric inflammation that lead to symptoms, erosive antral gastritis is the most common form. A direct correlation between the urea serum levels and the time in hemodialysis with the onset of gastric metaplasia and dyspepsia can be observed. The aim of this study was to report the endoscopic alterations found in hemodialysis patients. Methods: This is a cross-sectional study based on the medical records of 95 patients older than 18 years who were diagnosed with chronic kidney disease. The results of endoscopies performed up to 6 months before the beginning of the study were included. Results: Among the 95 studied patients, 56.84% were male, 60% were Caucasian, and 71.57% used proton pump inhibitors. The endoscopic alteration most frequently observed was erosive gastritis (77% of the cases); however, the frequency of the alteration that caused the symptoms was irrelevant. The antrum was the most common site of involvement (55.79%). Conclusion: Patients with chronic kidney disease often show dyspeptic symptoms. Other abnormalities are common but are not correlated with such symptoms. In conclusion, this study identified the endoscopic alterations that are most often observed in hemodialysis patients; erosive and enanthematous gastritis were the most common forms observed. Keywords: hemodialysis, chronic kidney disease, dyspepsia