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1. Signal transduction inhibitors, hibarimicins A, B, C, D and G produced by Microbispora. II. Structural studies.

Author

Hori H, Igarashi Y, Kajiura T, Furumai T, Higashi K, Ishiyama T, Uramota M, Uehara Y, and Oki T

Subjects
Carbohydrates chemistry, Enzyme Inhibitors chemistry, Enzyme Inhibitors pharmacology, Magnetic Resonance Spectroscopy, Molecular Structure, Protein-Tyrosine Kinases antagonists & inhibitors, Spectrometry, Mass, Fast Atom Bombardment, Actinomycetales chemistry, Anti-Bacterial Agents chemistry, Anti-Bacterial Agents pharmacology, Signal Transduction drug effects
Abstract

The structure of hibarimicins A, B, C, D and G which are inhibitors for tyrosine specific protein kinase are determined using spectroscopic techniques. Hibarimicins described in this report consist of a common aglycon and six deoxyhexoses. The aglycon contains a highly oxidized naphtylnaphthoquinone as a chromophore. Among them, hibarimicin B was identical with angelmicin B.

Published
1998
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