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To validate active human body models for investigating occupant safety in autonomous cars, it is crucial to comprehend the responses of vehicle occupants during evasive maneuvers. This study sought to quantify the behavior of midsize male and small female passenger seat occupants in both upright and reclined postures during three types of vehicle maneuvers. Volunteer tests were conducted using a minivan, where vehicle kinematics were measured with a DGPS sensor and occupant kinematics were captured with a stereo-vision motion capture system. Seatbelt loads, belt pull-out, and footrest reaction forces were also documented. The interior of the vehicle was 3D-scanned for modeling purposes. Results indicated that seatback angles significantly affected occupant kinematics, with small female volunteers displaying reduced head and torso movements, except during emergency braking with a upright posture seatback. Lane-change maneuvers revealed that maximum lateral head excursions varied depending on the maneuver's direction. The study concluded that seatback angles were crucial in determining the extent of occupant movement, with notable variations in head and torso excursions observed. The collected data assist in understanding occupant behavior during evasive maneuvers and contribute to the validation of human body models, offering essential insights for enhancing safety systems in autonomous vehicles. [ABSTRACT FROM AUTHOR]

Introduction and Hypothesis: The gold standard for quantifying pelvic organ prolapse is the pelvic organ prolapse quantification (POP-Q) system; however, upright magnetic resonance imaging (MRI) is a promising new method. The objective of this study was to determine the correlation between POP-Q and MRI measurements of the bladder and cervix. Methods: This prospective study included patients with prolapse in whom POP-Q points Aa or Ba and C were measured as standard care. MRI scans were performed in an upright position, and the distances of the lowest points of the bladder and cervix to the Pelvic Inclination Correction System (PICS) were calculated. Correlations between POP-Q and MRI-PICS measurements were determined using the Pearson correlation coefficient for normally distributed data and the Spearman's rank correlation coefficient for non-normally distributed data. Results: A total of 63 patients were suitable for analysis. There was a moderate positive correlation between the POP-Q and MRI-PICS measurements for bladder (r(61) = 0.480, r < 0.001) and uterus (r(61) = 0.527, p < 0.001). Measurement differences between POP-Q and MRI-PICS of the bladder and uterus vary from −3.2 cm to 7.1 cm, and from −2.1 cm to 8.5 cm respectively. In 71.4% of patients more descent was seen on upright MRI than with POP-Q measurement for both bladder and uterus. For patients with similar POP-Q measurements, a high variation in MRI measurements of the bladder and uterus was found. Conclusion: Despite a moderate positive correlation, upright MRI shows a larger POP extent in 71.4% of the patients than POP-Q. A high variation in MRI measurements for patients with the same POP-Q measurement was seen. [ABSTRACT FROM AUTHOR]

To validate active human body models for investigating occupant safety in autonomous cars, it is crucial to comprehend the responses of vehicle occupants during evasive maneuvers. This study sought to quantify the behavior of midsize male and small female passenger seat occupants in both upright and reclined postures during three types of vehicle maneuvers. Volunteer tests were conducted using a minivan, where vehicle kinematics were measured with a DGPS sensor and occupant kinematics were captured with a stereo-vision motion capture system. Seatbelt loads, belt pull-out, and footrest reaction forces were also documented. The interior of the vehicle was 3D-scanned for modeling purposes. Results indicated that seatback angles significantly affected occupant kinematics, with small female volunteers displaying reduced head and torso movements, except during emergency braking with a upright posture seatback. Lane-change maneuvers revealed that maximum lateral head excursions varied depending on the maneuver’s direction. The study concluded that seatback angles were crucial in determining the extent of occupant movement, with notable variations in head and torso excursions observed. The collected data assist in understanding occupant behavior during evasive maneuvers and contribute to the validation of human body models, offering essential insights for enhancing safety systems in autonomous vehicles.

Introduction and hypothesis: Symptoms of pelvic organ prolapse (POP) can affect quality of life and are reported to progress during the day, although this was never objectified. The aim of this study is to determine whether the pelvic anatomy changes during the day using upright magnetic resonance imaging (MRI), in POP patients and asymptomatic women. Methods: In this prospective study 15 POP patients and 45 asymptomatic women were included. Upright MRI scans were obtained three times per day. The distances from the lowest points of the bladder and cervix to a standardized reference (pelvic inclination correction system) line were determined. A principal component analysis was performed on the levator plate (LP) shape. Statistical differences between time points and the groups were determined for the bladder, cervix, and LP shape. Results: For all women a significant decrease in bladder and cervix height of −0.2 cm (p<0.001) was seen between morning/midday and afternoon scans. A significant difference in bladder descent during the day between POP patients and asymptomatic women was found (p=0.004). Individual differences in bladder position in the POP group of up to 2.2 cm between the morning and afternoon scan were reported. There was a significant difference in LP shape (p<0.001) between the groups but there were no significant changes during the day. Conclusions: This study found no clinically relevant pelvic anatomy changes during the day. Still, on an individual level differences can be large, so repeating clinical examination at the end of the day can be recommended in patients when anamnesis and physical examination do not match. [ABSTRACT FROM AUTHOR]

In Chinese language and culture, there are many metaphorical habits that use upright or skew shapes to express morality. Three experiments were conducted to determine whether there is a psychological metaphor in the cognition of Chinese people. To explore the psychological metaphorical associations between moral concepts and upright/skew shapes, the Stroop-like paradigm was used in Experiment 1, which showed that participants responded faster to positive moral words. There are some disputes regarding whether the metaphorical association is unidirectional or bidirectional in mapping. In Experiment 2, the priming paradigm was adopted, and the results showed that the priming of upright/skew shapes affected the judgment of moral words, and the priming of moral words also affected the judgment of upright/skew shapes, indicating bidirectional mapping between moral concepts and upright/skew shapes. We also wanted to determine whether this metaphorical association had any effect on face recognition. In Experiment 3, participants were asked to judge neutral faces presented with quadrilateral or oblique quadrilateral faces. We found that participants tended to think that upright faces were more moral, while skew faces were more immoral. Our study found a psychological metaphorical association between moral concepts and upright/skew shapes, bidirectional mapping, and its effect on face cognition. [ABSTRACT FROM AUTHOR]

An upright is the most crucial component of the suspension system of an All-terrain vehicle. It acts as a link for other component such as suspension arms, drive axle, steering tie rod, wheel hub, and brake calliper enabling a smooth comfortable ride. The upright has to withstand the entire force experienced during the dynamics of the vehicle before the energy is dampened by the coil-overs. The brake calliper is mounted on the upright and thus it has to withstand the forces generated during braking. Considering these factors, the design of the upright has to be highly efficient and done with utmost precision ensuring no or minimum failure. This paper outlines the design, analysis and optimization of the upright to be used in the ATV that will participate in BAJA SAE events of India and USA. The basic sketch necessary to design the upright is created in the form of a line diagram of the front geometry suspension system in Solid works. This geometry is then analysed using LOTUS software ensuring a near to perfect ride and handling. The 3D CAD model of the upright is designed in Solid works with respect to the front geometry of the suspension. The static structural analysis of the model is then performed on ANSYS mechanical followed by topological optimization of the model. Based on the results from this analysis, the improved CAD model of the upright has been designed and analysed. The main objective of this paper is to come up with a highly optimized design that ensures a high factor of safety while maintaining a lower weight. These optimizations proved to be helpful by reducing the weight of the component around 60 grams and increasing the factor of safety from 1.58 to 2.43. [ABSTRACT FROM AUTHOR]

Introduction and hypothesis: Pelvic organ prolapse quantification by means of upright magnetic resonance imaging (MRI) is a promising research field. This study determines the angle for the pelvic inclination correction system (PICS) for upright patient position, which is hypothesized to deviate from the supine PICS angle. The necessity of different PICS angles for various patient positions will also be discussed. Methods: Magnetic resonance scans of 113 women, acquired in an upright patient position, were used to determine the upright PICS angle, defined as the angle between the sacrococcygeal–inferior pubic point (SCIPP) line and the horizontal line. The difference and correlation between the upright and supine PICS angles were calculated using the paired Student's t-test and the Pearson's correlation coefficient (r) respectively. The effect of the difference between the upright and supine PICS angle on the measured pelvic organ extent was calculated using goniometry. Results: The mean (interquartile range) PICS angles were 29° (26–35°) for the upright and 33° (30–37°) for the supine patient position. They were significantly different (p<0.001) and very strongly correlated (r = 0.914, p<0.001). The 4° difference between the average upright and supine PICS angle results in an average underestimation of the measured cervix height of approximately 0.5 cm for patients scanned in upright position. Conclusions: The PICS angle for the upright patient position is 29°. The use of a dedicated PICS angle for different patient positions allows for more accurate pelvic organ extent analysis in patients with prolapse. [ABSTRACT FROM AUTHOR]

Face and body perception rely on specialized processing mechanisms to interpret social information efficiently. The body inversion effect (BIE), refers to an inversion effect for bodies, such that recognition of bodies is impaired by inversion. The BIE, like the face inversion effect (FIE), is particularly important because a disproportionate BIE relative to inversion effects for objects could be interpreted in much the same way as the disproportionate FIE has often been characterized; that is, as evidence of specialized, configural processing. However, research supporting the BIE is marked by methodological heterogeneity and mixed findings. Our multilevel Bayesian meta-analysis addresses inconsistencies in the literature by pooling data from numerous studies to estimate the magnitude of the BIE across various methodological and stimulus properties. We included 180 effect sizes from 41 empirical articles representing data from 2,274 participants. Overall, we found that the BIE was moderate-large in magnitude (Hedges' g = 0.75). Importantly, the inversion effect was larger for bodies than objects (b = 0.42); however, the inversion effect for faces was larger than for bodies (b = 0.34). We tested the role of discrimination dimension, stimulus type, face/head inclusion, stimulus sexualization, and sexualized stimulus sex as moderators of the BIE. We found that the BIE was moderated by discrimination dimension, stimulus type, stimulus sexualization, and sexualized stimulus sex. By synthesizing the existing literature, we provide a better theoretical understanding of how underlying visual processing mechanisms may differ for different types of social information (i.e., bodies vs. faces). [ABSTRACT FROM AUTHOR]

Abstract Background Degenerative disease of the lumbar spine is one of the most prevalent pathologies worldwide, and MRI is the gold standard imaging modality that helps to assess soft tissue and bony abnormalities and elicit causes of neural compression. It is not uncommon in the daily practice to have patients presenting with neurological symptoms during standing or walking while MRI fails to detect lesion that explains their clinical picture. The aim of this study was to detect changes that appear on dynamic weight-bearing MRI of the lumbar spine that was hidden on conventional supine MRI and to correlate them with the clinical situation. Methodology Ninety patients with back pain were enrolled in the study, they did conventional and dynamic MRI of the lumbar spine. We compared findings in both modalities as regard alignment, ligamentum flavum buckling, foraminal narrowing and neural compression. Results Dynamic MRI showed neural compression in 87% of patients in comparison to supine MRI, ligamentum flavum buckling was reported in 80%, neural foraminal narrowing was seen in 24%, exaggeration of the lumbar lordoisis in 10% and exaggeration of the already existing disc protrusion was documented in 60% of the included patients. Conclusions Upright dynamic MRI has added to supine MRI in problem solving cases with clinical radiological mismatch. The results indicated changes in the spine alignment, neural compression and spinal canal stenosis. Since the examination is non-invasive, it could be used in the preoperative planning of patients with degenerative lumbar spine disease.

Delivering radiotherapy to patients in an upright position can allow for increased patient comfort, reduction in normal tissue irradiation, or reduction of machine size and complexity. This paper gives an overview of the requirements for the delivery of contemporary arc and modulated radiation therapy to upright patients. We explore i) patient positioning and immobilization, ii) simulation imaging, iii) treatment planning and iv) online setup and image guidance. Treatment chairs have been designed to reproducibly position seated patients for treatment and can be augmented by several existing immobilisation systems or promising emerging technologies such as soft robotics. There are few solutions for acquiring CT images for upright patients, however, cone beam computed tomography (CBCT) scans of upright patients can be produced using the imaging capabilities of standard Linacs combined with an additional patient rotation device. While these images will require corrections to make them appropriate for treatment planning, several methods indicate the viability of this approach. Treatment planning is largely unchanged apart from translating gantry rotation to patient rotation, allowing for a fixed beam with a patient rotating relative to it. Rotation can be provided by a turntable during treatment delivery. Imaging the patient with the same machinery as used in treatment could be advantageous for online plan adaption. While the current focus is using clinical linacs in existing facilities, developments in this area could also extend to lower-cost and mobile linacs and heavy ion therapy. [ABSTRACT FROM AUTHOR]

Delivering radiotherapy to patients in an upright position can allow for increased patient comfort, reduction in normal tissue irradiation, or reduction of machine size and complexity. This paper gives an overview of the requirements for the delivery of contemporary arc and modulated radiation therapy to upright patients. We explore i) patient positioning and immobilization, ii) simulation imaging, iii) treatment planning and iv) online setup and image guidance. Treatment chairs have been designed to reproducibly position seated patients for treatment and can be augmented by several existing immobilisation systems or promising emerging technologies such as soft robotics. There are few solutions for acquiring CT images for upright patients, however, cone beam computed tomography (CBCT) scans of upright patients can be produced using the imaging capabilities of standard Linacs combined with an additional patient rotation device. While these images will require corrections to make them appropriate for treatment planning, several methods indicate the viability of this approach. Treatment planning is largely unchanged apart from translating gantry rotation to patient rotation, allowing for a fixed beam with a patient rotating relative to it. Rotation can be provided by a turntable during treatment delivery. Imaging the patient with the same machinery as used in treatment could be advantageous for online plan adaption. While the current focus is using clinical linacs in existing facilities, developments in this area could also extend to lower-cost and mobile linacs and heavy ion therapy.

Background: Therapeutic head positioning plays a role in the management of patients with acute brain injury. Although intracranial pressure (ICP) is typically lower in an upright posture than in a flat position, limited data exist concerning the effect of upright positioning on brain oxygenation and circulation. We sought to determine the impact of supine (0°) and semirecumbent (15° and 30°) postures on ICP, brain oxygenation, and brain circulation. Methods: An observational cohort study was conducted between February 2012 and September 2015. Twenty-three patients with severe acute brain injury were successively observed at head elevations of 30°, 15°, and 0°. Postural-induced changes in ICP, cerebral perfusion pressure, brain tissue oxygenation pressure, and transcranial Doppler findings were simultaneously measured during three repeated experiments: 24 h after admission to the intensive care unit (exp1), 24 h later (exp2), and 96 h later (exp3). Cerebral perfusion pressure, arterial blood gases, hemoglobin content, and body temperature remained unchanged during the three experiments. Results: Using linear random-slope mixed models, we found that during the early phase of acute brain injury (exp1), lowering the head posture from 30° to 15°, and then to 0°, was associated with a gradual mean ICP increase of 2.6 mm Hg (1.4–3.7 mm Hg; P < 0.001); and from 30° to 0°, an increase of 7.4 mm Hg (6.3–8.6 mm Hg; P < 0.001). Furthermore, brain tissue oxygenation pressure and mean blood flow velocity improved when the head posture was lowered from 30° to 0° by 1.2 mm Hg (0.2–2.3 mm Hg) and 4.1 cm/s (0.0–8.2 cm/s), respectively (both P < 0.05). Conclusions: Changing the positioning of stable patients with acute brain injury resulted in opposite changes of ICP versus brain oxygenation and circulation. This information supports the concept of an individualized approach to head positioning that is based on the multimodal monitoring of brain parameters. [ABSTRACT FROM AUTHOR]

Background: Degenerative disease of the lumbar spine is one of the most prevalent pathologies worldwide, and MRI is the gold standard imaging modality that helps to assess soft tissue and bony abnormalities and elicit causes of neural compression. It is not uncommon in the daily practice to have patients presenting with neurological symptoms during standing or walking while MRI fails to detect lesion that explains their clinical picture. The aim of this study was to detect changes that appear on dynamic weight-bearing MRI of the lumbar spine that was hidden on conventional supine MRI and to correlate them with the clinical situation. Methodology: Ninety patients with back pain were enrolled in the study, they did conventional and dynamic MRI of the lumbar spine. We compared findings in both modalities as regard alignment, ligamentum flavum buckling, foraminal narrowing and neural compression. Results: Dynamic MRI showed neural compression in 87% of patients in comparison to supine MRI, ligamentum flavum buckling was reported in 80%, neural foraminal narrowing was seen in 24%, exaggeration of the lumbar lordoisis in 10% and exaggeration of the already existing disc protrusion was documented in 60% of the included patients. Conclusions: Upright dynamic MRI has added to supine MRI in problem solving cases with clinical radiological mismatch. The results indicated changes in the spine alignment, neural compression and spinal canal stenosis. Since the examination is non-invasive, it could be used in the preoperative planning of patients with degenerative lumbar spine disease. [ABSTRACT FROM AUTHOR]

Formula SAE (FSAE) is a competition where university students are challenged to design, fabricate and race small open-wheeled vehicles. This work outlines the development and analysis of a wheel assembly for a race car which carried out by the James Cook University Motorsports. A number of strategies are utilized throughout the paper including load calculations, modelling by SolidWorks and finite element analysis via Ansys for each part of the system including the upright, braking system and hub shaft.

This paper describes the design and optimisation of rear wheel assembly for an all-terrain vehicle. The components of rear wheel assembly are designed with an optimised design intent with light weight material selection. The designed assembly is then discretised using finite element modelling through Hexa-dominant 3D mesh. The upright knuckle and the hub are assessed for their integrity check and the performance of full assembly is verified through simulation. From the post-processed stress results, factor of safety for the designed parts is presented. The presented work can be expanded to optimise the upright and the hub based the resolved gradient stress plots from the finite element analysis. [ABSTRACT FROM AUTHOR]

This study evaluates an innovative reinforcement method for cold-formed steel (CFS) upright sections through finite element assessment as well as prediction of the normalized ultimate load and deflection of the profiles by artificial intelligence (AI) and machine learning (ML) techniques. Following the previous experimental studies, several CFS upright profiles with different lengths, thicknesses and reinforcement spacings are modeled and analyzed under flexural loading. The finite element method (FEM) is employed to evaluate the proposed reinforcement method in different upright sections and to provide a valid database for the analytical study. To detect the most influential factor on flexural strength, the "feature selection" method is performed on the FEM results. Then, by using the feature selection method, a hybrid neural network (a combination of multi-layer perceptron algorithm and particle swarm optimization method) is developed for the prediction of normalized ultimate load. The correlation coefficient (R), root mean square error (RMSE), Nash–Sutcliffe efficiency (NSE), mean absolute error (MAE) and Wilmot's index of agreement (WI) are used as the measure of precision. The results show that the geometrical parameters have almost the same contribution in the flexural capacity and deflection of the specimens. According to the performance evaluation indexes, the best model is detected and optimized by tuning other algorithm parameters. The results indicate that the hybrid neural network can successfully predict the normalized ultimate load and deflection. [ABSTRACT FROM AUTHOR]

This article purposes on developing and on re-interpreting the numerical results of a topology optimization for a structural component built via additive manufacturing. A critical appraisal of the optimization results is presented by modeling the feasible component with a holistic approach that merges structural and manufacturing requirements. The procedure is expected to provide a design guideline for similar applications of practical relevance, toward an increase of the right-first-time parts that is required to bring additive manufacturing to its full competitiveness. Topology optimization of a steering upright for a Formula SAE racing car was performed by targeting weight minimization while complying with severe structural constraints, like global and local stiffness performance. Cornering, bumping and braking vehicle conditions were considered. The optimization constraints were evaluated via finite element analysis on a reference component, where the loading conditions were retrieved from telemetry data. The reference part was manufactured by computer numerical control machining from a solid aluminum block. Spurred by the interpretation of the topology optimization predictions, a new upright geometry was designed and validated by calculating its stress field and the possible occurrence of Euler buckling. The new upright was 9% lighter than the reference component. The new geometry was analyzed according to Design for Additive Manufacturing principles to choose the orientation on the build platform and the supports' location and geometry. The part was successfully manufactured and proved consistent with the application. [ABSTRACT FROM AUTHOR]

Since the early days of megavoltage Radiation Therapy (RT), the potential of delivering treatment to a sub group of patients in an upright position has been recognized. Compared to lying horizontally, treating patients in an upright position offers potential benefits in terms of patient comfort especially for patients experiencing dyspnoea and saliva accumulation when lying down. Dosimetric benefits can also be gained from changes in the volume and location of lungs and heart in an upright position, which are potentially advantageous for clinical situations including Hodgkin's disease, lung and breast malignancies. Since the 1950's, upright stabilization mechanisms have ranged from standalone chair based apparatus to couch-top attachments with increasingly customizable solutions. The introduction of Computed-Tomography (CT) based three-dimensional (3D) dosimetry in the 1980's−90's necessitated image acquisition in a horizontal position (supine or prone), significantly reducing options for alternative patient positioning and upright techniques. Despite this, upright techniques have still been utilized where clinically indicated for palliative and novel approaches often involving non-standard treatment scenarios. More recently, a small number of centers have reported on specialized equipment capable of acquiring planning data with the patient in a vertical position. The possibility of acquiring planning quality Cone Beam CT (CBCT) on linear accelerators has recently reinvigorated the potential to deliver highly accurate and targeted treatments to patients in an upright position. This paper reflects on the historical applications of upright RT and explores new possibilities for this technology in modern RT departments.

The purpose of this study was to examine the effects of posture on interpretation bias, mood, and physical tension when using a mobile device. Participants were randomly assigned to one of three conditions: sitting slumped, sitting upright, or lying down. They were then asked to unscramble emotional and neutral sentences to measure interpretation bias. Self-reported measurements were used to measure mood and physical tension. No significant differences were found in the type of sentence unscrambled when sitting slumped and upright. When lying down, participants unscrambled fewer neutral sentences compared to emotional sentences. Physical tension was found to mediate the relationship between posture (slumped and upright) and mood. The results of this study provide insight into possible confounding variables influencing the relationship between posture and mood. Additionally, we showed that emotional content is processed differently compared to neutral content when lying down. Further research is needed to understand how psychological well-being is affected by physical tension caused by posture when using a mobile device. [ABSTRACT FROM AUTHOR]

Perforated cold-formed steel (CFS) beams subjected to different bending scenarios should be able to deal with different buckling modes. There is almost no simple way to address this significant concern. This paper investigates the bending capacity and flexural behavior of a novel-designed system using bolt and nut reinforcing system through both experimental and numerical approaches. For the experiential program, a total of eighteen specimens of three types were manufactured: a non-reinforced section, and two sections reinforced along the upright length at 200 mm and 300 mm pitches. Then, monotonic loading was applied to both the minor and major axes of the specimens. The finite element models were also generated and proved the accuracy of the test results. Using the proposed reinforcing system the flexural capacity of the upright sections was improved around either the major axis or minor axis. The 200 mm reinforcement type provided the best performance of the three types. The proposed reinforcing pattern enhanced flexural behavior and constrained irregular buckling and deformation. Thus, the proposed reinforcements can be a very useful and cost-effective method for strengthening all open CFS sections under flexural loading, considering the trade-off between flexural performance and the cost of using the method. [ABSTRACT FROM AUTHOR]

Since the early days of megavoltage Radiation Therapy (RT), the potential of delivering treatment to a sub group of patients in an upright position has been recognized. Compared to lying horizontally, treating patients in an upright position offers potential benefits in terms of patient comfort especially for patients experiencing dyspnoea and saliva accumulation when lying down. Dosimetric benefits can also be gained from changes in the volume and location of lungs and heart in an upright position, which are potentially advantageous for clinical situations including Hodgkin's disease, lung and breast malignancies. Since the 1950's, upright stabilization mechanisms have ranged from standalone chair based apparatus to couch-top attachments with increasingly customizable solutions. The introduction of Computed-Tomography (CT) based three-dimensional (3D) dosimetry in the 1980's−90's necessitated image acquisition in a horizontal position (supine or prone), significantly reducing options for alternative patient positioning and upright techniques. Despite this, upright techniques have still been utilized where clinically indicated for palliative and novel approaches often involving non-standard treatment scenarios. More recently, a small number of centers have reported on specialized equipment capable of acquiring planning data with the patient in a vertical position. The possibility of acquiring planning quality Cone Beam CT (CBCT) on linear accelerators has recently reinvigorated the potential to deliver highly accurate and targeted treatments to patients in an upright position. This paper reflects on the historical applications of upright RT and explores new possibilities for this technology in modern RT departments. [ABSTRACT FROM AUTHOR]

This article presents the foundation of classical Chinese medical thinking - the concept of yin and yang - and how this informs clinical practice. The author explains how, particularly since the Song Dynasty, there has been a tendency for clinicians to misunderstand this concept by focusing on a narrow meaning of yin and yang at the expense of a broader understanding. From the classical perspective, yin and yang are not proper nouns that describe static and distinct entities, but rather relative descriptors that express the constantly changing nature of the whole of existence. The explanation includes a discussion of the classical understanding of the concepts of qi and blood, and upright and pernicious. Clinical examples are provided that illustrate the theory. [ABSTRACT FROM AUTHOR]

Abstract Background Sitting too much has been associated with negative health outcomes. ‘The End of Sitting’ is a newly developed office landscape that moves away from the traditional chair-desk setup. The landscape aims to reduce sitting time by offering a variety of (supported) standing positions. The aim of this study was to determine the usage of the landscape after being placed in the main entrance hall of the VU University in Amsterdam. Methods We observed the number of spontaneous visitors as well as the duration of visits, changes to another location within the landscape, and adopted postures. Using questionnaires reasons (not) to visit the landscape, perceived affordances of the landscape and associations with long-term use were determined. Results Observed numbers of visitors were relatively low and duration of visits were short, which seemed to indicate visitors were trying out the landscape. The majority of visitors were in an upright position, reflecting the designers’ intentions. Visitors indicated that long-term use would be pleasant to them. Conclusion ‘The End of Sitting’ landscape received positive reactions but number of visits were limited in the few months that it was placed in the university main entrance hall. The landscape might be better suited for designated working or study spaces, for which it was originally intended. It might also be worth to explore the landscapes suitability for short stay environments, such as waiting rooms.

In an attempt to improve sesame for reduction of seed loss due to shattering of capsule at harvest, the seeds of three varieties of sesame (NCRIBEN-04E, NCRIBEN-01M and NCRIBEN-03L) were treated with five different doses (0, 250, 350, 450 and 550 Gy) of gamma irradiation; 0 Gy being the control. All the treatments including the controls, were grown and monitored till maturity. The seed retention power of the treatments were assessed. From the results, the treatment due to 550 Gy had highest score (6) for both NCRIBEN-04E and NCRIBEN-01M and was categorized as non-shattering (NSH) type. All other treatments were categorized as shattering (SHA) type. Similarly all the treatments from NCRIBEN-03L were categorized as SHA with treatment due to 250 Gy having highest score (5). The three varieties showed positive correlations between the seed/capsule in upright (U) and seed/capsule in inverted (I) position but NCRIBEN-01M was not significant (r = 0.650). The NCRIBEN-04E showed negative correlation between U and length of suture (L) and I and L (r = -0.570 and -0.358 respectively). This result has shown that the dose 550 Gy seems to be promising in generating mutants with high resistance to capsule shattering in sesame. There is need to advance these mutants to M2 and M3 generations to ascertain this seed retention capacity.

Protracting lower second molars and uprighting horizontally impacted third molars is a significant orthodontic challenge in patients who require the extraction of severely decayed first molars. Here, we describe the use of biomechanics to upright 90°-tilted lower third molars following second molar protraction. Herein, we introduce a technique for uprighting the lower third molars by (1) the placement of superelastic nickel titanium archwires, (2) bonding, and (3) repositioning of a buccal tube in a tilted position to compensate for the efficiency of Ni-Ti (nickel-titanium) wire. The treatment mechanics used for our two cases showed that even severely impacted third molars can be uprighted by routine continuous straight-wire techniques. This technique proved to be a simple, efficient and reliable treatment option for uprighting horizontally impacted third molars., Competing Interests: The authors declare no conflict of interest., (©2024 The Author(s). Published by MRE Press.)

This study evaluates an innovative reinforcement method for cold-formed steel (CFS) upright sections through finite element assessment as well as prediction of the normalized ultimate load and deflection of the profiles by artificial intelligence (AI) and machine learning (ML) techniques. Following the previous experimental studies, several CFS upright profiles with different lengths, thicknesses and reinforcement spacings are modeled and analyzed under flexural loading. The finite element method (FEM) is employed to evaluate the proposed reinforcement method in different upright sections and to provide a valid database for the analytical study. To detect the most influential factor on flexural strength, the “feature selection” method is performed on the FEM results. Then, by using the feature selection method, a hybrid neural network (a combination of multi-layer perceptron algorithm and particle swarm optimization method) is developed for the prediction of normalized ultimate load. The correlation coefficient (R), root mean square error (RMSE), Nash–Sutcliffe efficiency (NSE), mean absolute error (MAE) and Wilmot’s index of agreement (WI) are used as the measure of precision. The results show that the geometrical parameters have almost the same contribution in the flexural capacity and deflection of the specimens. According to the performance evaluation indexes, the best model is detected and optimized by tuning other algorithm parameters. The results indicate that the hybrid neural network can successfully predict the normalized ultimate load and deflection.

Cold-formed steel (CFS) storage rack structures are extensively used in various industries to store products in safe and secure warehouses before distribution to the market. Thin-walled open profiles that are typically used in storage rack structures are prone to loss of stability due to different buckling modes such as local, distortional, torsional and flexural, or any interaction between these modes. In this paper, an efficient way of increasing ultimate capacity of upright frames under compression load is proposed using bolts and spacers which are added externally to the section with certain pitches along the height. Hereinto, experimental tests on 81 upright frames with different thicknesses and different heights were conducted, and the effect of employing reinforcement strategies was examined through the failure mode and ultimate load results. Non-linear finite element analyses were also performed to investigate the effect of different reinforcement spacing on the upright performance. The results showed that the reinforcement method could restrain upright flange and consequently increase the distortional strength of the upright profiles. This method can also be effective for any other light gauged steel open section with perforation. It was also observed that the reinforcement approach is much more useful for short length upright frames compared to the taller frames. [ABSTRACT FROM AUTHOR]

Magnetic resonance imaging (MRI) has an established role in the assessment of degenerative musculoskeletal conditions. However, conventional supine MRI findings often correlate poorly with clinical findings. Some patients experience accentuated back pain in the weight-bearing position. Therefore, supine MRI may underestimate the severity of degenerative spine findings. To try and improve the clinical validity of spine imaging, axial loading devices have been used with conventional supine MR imaging to simulate loading of the upright spine. More recently, upright weight-bearing MRI systems (0.25-0.6 T) were introduced, allowing images to be obtained in the standing or seated weight-bearing position and even during upright flexion or extension, rotation, or bending. Some scanners even enable capturing of real-time spinal movement. This review addresses the technical aspects and potential challenges of weight-bearing MRI, both in clinical practice and research. [ABSTRACT FROM AUTHOR]

Bare concrete using the nature of concrete surface as facing directly, this conforms to the modem aesthetic idea. Along with the people environmental protection consciousness, bare concrete application in public building is more and more widely. Combining bare concrete construction in the Macao Port administration building project, we carried out the study on construction technology and quality control of bare concrete, and achieved satisfactory results. The finished bare concrete fully meets the design requirements, which can provide reference for the popularization and application of bare concrete technology. [ABSTRACT FROM AUTHOR]

Perforated cold-formed steel (CFS) beams subjected to different bending scenarios should be able to deal with different buckling modes. There is almost no simple way to address this significant concern. This paper investigates the bending capacity and flexural behavior of a novel-designed system using bolt and nut reinforcing system through both experimental and numerical approaches. For the experiential program, a total of eighteen specimens of three types were manufactured: a non-reinforced section, and two sections reinforced along the upright length at 200 mm and 300 mm pitches. Then, monotonic loading was applied to both the minor and major axes of the specimens. The finite element models were also generated and proved the accuracy of the test results. Using the proposed reinforcing system the flexural capacity of the upright sections was improved around either the major axis or minor axis. The 200 mm reinforcement type provided the best performance of the three types. The proposed reinforcing pattern enhanced flexural behavior and constrained irregular buckling and deformation. Thus, the proposed reinforcements can be a very useful and cost-effective method for strengthening all open CFS sections under flexural loading, considering the trade-off between flexural performance and the cost of using the method.

This paper deals with the design of an upright using a topological optimization. This type of optimization is a relatively young and rapidly evolving area of computational mechanics that seeks to make multiple material savings that cannot be achieved by conventional methods. The optimized upright was utilized in a fully functional prototype of the student formula within the Formula Student competition. The main objective of the optimization was to meet the requirements of the physical properties, weight, stiffness, and strength of the upright. The initial model of the upright was iteratively optimized using topological optimization and a finite element static analysis to obtain the final model. Using the finite element analysis, its behavior in operation within individual load cases was predicted. Symmetry was used to mirror the finished model to obtain the opposite upright of the other side of the car. Finally, the topologically optimized upright was compared with an upright made by conventional methods.

Labor process is complex. Anatomically and physiologically must be monitored during labor process. Normal labor case is higher than labor with medical interventional. In Indonesia, labor process training still used conventional simulation media. The simulation can’t determined about labor process and monitoring during labor process. Thus, model that can simulate of labor process and monitoring during labor process in stage I and II must be provided This research expected to contribute in learning media to simulate normal labor process and monitored during labor process in stage I and II. Biomodeling expected to provide understanding about labor process, stage of labor, and monitoring during labor process. This research conducted with approach method scenario based model for simulate gameplay for normal labor process and monitoring in stage I and II. Based on literature about reproductive system organ and physiological, also must be monitored about physiological change during labor process with partograf WHO standard and analyze parameter to determined labor process closely with the reality. Beside that, theory of labor process and pushing in contraction also be analyze to find the basic formula from physic and mathematical concept. From the basic formula, modified basic formula for scenario gameplay simulation of normal labor process and monitoring in stage I and II.The result of this research was produce biomodeling to determine normal labor process, the stage of labor, and physiological monitoring for report that monitored appropriate with WHO partograf standard. This biomodeling expected become learning and training media for midwivery and doctor include student of medical and midwifery. Model that is produce from this research can be develop to abnormal labor process (medical interventional) include labor complication.

Objective Endoscopic transnasal skull base surgery is a valuable technique used in the surgical treatment of various skull base pathologies. In such surgeries, the reconstruction of the skull base is crucial for surgical success and minimizing complications. This study presents a new side-support surgical tray designed to improve the exposure of the lateral femoral surgical area during surgery, enhancing surgical efficiency and reducing the risk of surgical complications. The study compared this innovative tray stand with the conventional double-sided support tray stand to evaluate its impact on surgical procedures and complications. Materials and methods The study prospectively analyzed 248 endoscopic transnasal skull base surgeries requiring lateral femoral autologous tissue harvesting. One hundred fifty-eight cases were performed using the side-support surgical tray stand (experimental group), while 90 cases used the conventional double-sided support tray stand (control group). Various parameters were evaluated, including satisfaction scores of surgeons, circulating nurses, instrument nurses, and anesthetists, as well as objective outcomes such as surgical duration and the incidence of complications. Results Surgeons in the experimental group expressed higher satisfaction with the surgical field exposure and the portability of the surgical tray stand compared to the control group. Likewise, circulating nurses in the experimental group reported greater satisfaction with the installation and portability, surpassing that of the control group ( p < 0.01). Although the stability of instrument nurses in the experimental group was slightly less than that of the control group, it had no discernible impact on surgical cooperation. Anaesthesiologists in the experimental group exhibited higher satisfaction regarding the convenience of intraoperative monitoring and management than their counterparts in the control group. The average duration required for intraoperative autologous tissue harvesting in the experimental group was significantly shorter than in the control group ( p  < 0.01). Furthermore, the incidence of postoperative wound infections and intracranial infections in the experimental group was notably lower than in the control group (would infections,  p  = 0.046; intracranial infection,  p  = 0.025). Conclusion The novel side-support surgical tray stand effectively improves surgical exposure, convenience, and safety while reducing the risk of surgical site and intracranial infections. It also shortens surgical duration and lowers complication rates, making it a suitable choice for clinical application., Competing Interests: The patent for this side-supported tray stand was issued by China National Intellectual Property Administration (no. ZL 202020645462.X)., (Copyright © 2023, Zhang et al.)

Subjective visual vertical (SVV) assesses the ability to perceive verticality, which is a measure of vestibular otolithic function. Vestibular lesions influence this perception of verticality. We developed a method using virtual reality (VR) display and an Android software application named ‘Curator SVV’. The virtual reality SVV (Curator SVV) consisted of ten readily identifiable artworks projected by a Samsung phone S6 which is inserted into a virtual reality headset. In the first study, 20 patients had there SVV assessed with two devices: (1) a commercially available SVV measurement device (VestiTest®) and (2) a virtual reality SVV using the Curator SVV application. In a second study, 32 healthy subjects had their SVV assessed by the Curator SVV application whilst sitting in a chair. In the first study, there was no significant difference (p = 0.44, paired t test and p = 0.01, test of equivalence) between results obtained by Curator SVV and the commercially available device. In the second study, the average angle measured for healthy subjects was 0.00° ± 0.85°. The normal range (mean ± 2 SD) was ± 2° in standard upright position. We were able to demonstrate that the Curator SVV can be readily employed as an objective, non-invasive and affordable means of assessing otolith function in the clinical context. We validated this novel methodology by finding strong quantitative parity between a standard commercial SVV unit and the VR Curator SVV method. Our very lightweight and mobile device can be employed in clinical contexts including at the bedside and in different head and body positions. [ABSTRACT FROM AUTHOR]

Magnetic resonance imaging (MRI) is the established technique for evaluating the spine. Unfortunately, the supine position of the patient during conventional MRI scanning does not truly reflect the physiological forces experienced by the discoligamentous structures during normal upright posture and ambulation. Upright MRI is a relatively new technique that allows the patient to be scanned in several different weight-bearing positions, which may potentially demonstrate occult pathology not visualised in the supine position. The imaging technique and current clinical indications of upright spinal MRI would be discussed. [ABSTRACT FROM AUTHOR]

Background: Compare Goldmann applanation tonometer (GAT) prism and correcting applanation tonometry surface (CATS) prism to intracameral intraocular pressure (IOP), in vivo and in vitro.Methods: Pressure transducer intracameral IOP was measured on fifty-eight (58) eyes undergoing cataract surgery and the IOP was modulated manometrically to 10, 20, and 40 mmHg. Simultaneously, IOP was measured using a Perkins tonometer with a standard GAT prism and a CATS prism at each of the intracameral pressures. Statistical comparison was made between true intracameral pressures and the two prism measurements. Differences between the two prism measurements were correlated to central corneal thickness (CCT) and corneal resistance factor (CRF). Human cadaver eyes were used to assess measurement repeatability.Results: The CATS tonometer prism measured closer to true intracameral IOP than the GAT prism by 1.7+/-2.7 mmHg across all pressures and corneal properties. The difference in CATS and GAT measurements was greater in thin CCT corneas (2.7+/-1.9 mmHg) and low resistance (CRF) corneas (2.8+/-2.1 mmHg). The difference in prisms was negligible at high CCT and CRF values. No difference was seen in measurement repeatability between the two prisms.Conclusion: A CATS prism in Goldmann tonometer armatures significantly improve the accuracy of IOP measurement compared to true intracameral pressure across a physiologic range of IOP values. The CATS prism is significantly more accurate compared to the GAT prism in thin and less rigid corneas. The in vivo intracameral study validates mathematical models and clinical findings in IOP measurement between the GAT and CATS prisms. [ABSTRACT FROM AUTHOR]

In this article, I advance a novel hypothesis on the evolution of hominin bipedalism. I begin by arguing extensively for how the transition to bipedalism must have been problematic for hominins during the Neogene. Due to this and the fact that no other primate has made the unusual switch to bipedalism, it seems likely that the selection pressure towards bipedalism was unusually strong. With this in mind, I briefly lay out some of the most promising hypotheses on the evolutionary origin of hominin bipedalism and show how most, if not all, fail in the face of the need for an unusually strong selection pressure. For example, some hypotheses maintain that hominins became bipedal so they could use their hands for carrying infants, food, or other valuable objects. But extant apes are able to carry objects in one of their front limbs (while walking with the other three), and thus it does not seem plausible that our hominin ancestors went through the troublesome transition to bipedalism just so they could carry objects a little more efficiently. After I show that past hypotheses are wanting in the face of this challenge, I argue that there is only one selection pressure powerful enough to instigate a strange and problematic evolutionary adaptation like bipedalism, and that is sexual selection. Specifically, from the fact that bipedal locomotion is an important strategy for intimidating others and ascending the dominance hierarchy in extant apes, I argue that for no particular selective reason bipedal locomotion became a signal for high fitness (much as a large and intricate tail became a signal for high fitness for peahens), and this led to the trait being continuously reinforced in spite of all its deleterious fitness consequences. [ABSTRACT FROM AUTHOR]

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Background: Sitting too much has been associated with negative health outcomes. 'The End of Sitting' is a newly developed office landscape that moves away from the traditional chair-desk setup. The landscape aims to reduce sitting time by offering a variety of (supported) standing positions. The aim of this study was to determine the usage of the landscape after being placed in the main entrance hall of the VU University in Amsterdam.Methods: We observed the number of spontaneous visitors as well as the duration of visits, changes to another location within the landscape, and adopted postures. Using questionnaires reasons (not) to visit the landscape, perceived affordances of the landscape and associations with long-term use were determined.Results: Observed numbers of visitors were relatively low and duration of visits were short, which seemed to indicate visitors were trying out the landscape. The majority of visitors were in an upright position, reflecting the designers' intentions. Visitors indicated that long-term use would be pleasant to them.Conclusion: 'The End of Sitting' landscape received positive reactions but number of visits were limited in the few months that it was placed in the university main entrance hall. The landscape might be better suited for designated working or study spaces, for which it was originally intended. It might also be worth to explore the landscapes suitability for short stay environments, such as waiting rooms. [ABSTRACT FROM AUTHOR]

Background: Goldmann applanation tonometry (GAT) error relative to intracameral intraocular pressure (IOP) has not been examined comparatively in both human cadaver eyes and in live human eyes. Futhermore, correlations to biomechanical corneal properties and positional changes have not been examined directly to intracameral IOP and GAT IOP.Methods: Intracameral IOP was measured via pressure transducer on fifty-eight (58) eyes undergoing cataract surgery and the IOP was modulated manometrically on each patient alternately to 10, 20, and 40 mmHg. IOP was measured using a Perkins tonometer in the supine position on 58 eyes and upright on a subset of 8 eyes. Twenty one (21) fresh human cadaver globes were Intracamerally IOP adjusted and measured via pressure transducer. Intracameral IOP ranged between 5 and 60 mmHg. IOP was measured in the upright position with a Goldmann Applanation Tonometer (GAT) and supine position with a Perkins tonometer. Central corneal thickness (CCT) was also measured.Results: The Goldmann-type tonometer error measured on live human eyes was 5.2 +/-1.6 mmHg lower than intracameral IOP in the upright position and 7.9 +/- 2.3 mmHg lower in the supine position (p < .05). CCT also indicated a sloped correlation to error (correlation coeff. = 0.18). Cadaver eye IOP measurements were 3.1+/-2.5 mmHg lower than intracameral IOP in the upright position and 5.4+/- 3.1 mmHg in the supine position (p < .05).Conclusion: Goldmann IOP measures significantly lower than true intracameral IOP by approximately 3 mmHg in vitro and 5 mmHg in vivo. The Goldmann IOP error is increased an additional 2.8 mmHg lower in the supine position. CCT appears to significantly affect the error by up to 4 mmHg over the sample size. [ABSTRACT FROM AUTHOR]