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2. Recommendations for determining HPV status in patients with oropharyngeal cancers under TNM8 guidelines: a two-tier approach

Author

Craig, Stephanie G., Anderson, Lesley A., Schache, Andrew G., Moran, Michael, Graham, Laura, Currie, Keith, Rooney, Keith, Robinson, Max, Upile, Navdeep S., Brooker, Rachel, Mesri, Mina, Bingham, Victoria, McQuaid, Stephen, Jones, Terry, McCance, Dennis J., Salto-Tellez, Manuel, McDade, Simon S., and James, Jacqueline A.

Published
2019
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4. Endocrine Emergencies

Author

Upile, Tahwinder, Upile, Navdeep, Mahil, Jaspal, Shergill, Iqbal, editor, Arya, Manit, editor, Upile, Tahwinder, editor, Arya, Neehar, editor, and Dasgupta, Prokar, editor

Published
2013
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5. Data from HPV-Related Oropharynx Cancer in the United Kingdom: An Evolution in the Understanding of Disease Etiology

Author

Schache, Andrew G., primary, Powell, Ned G., primary, Cuschieri, Kate S., primary, Robinson, Max, primary, Leary, Sam, primary, Mehanna, Hisham, primary, Rapozo, Davy, primary, Long, Anna, primary, Cubie, Heather, primary, Junor, Elizabeth, primary, Monaghan, Hannah, primary, Harrington, Kevin J., primary, Nutting, Christopher M., primary, Schick, Ulrike, primary, Lau, Andy S., primary, Upile, Navdeep, primary, Sheard, Jon, primary, Brougham, Kath, primary, West, Catharine M.L., primary, Oguejiofor, Ken, primary, Thomas, Steve, primary, Ness, Andy R., primary, Pring, Miranda, primary, Thomas, Gareth J., primary, King, Emma V., primary, McCance, Dennis J., primary, James, Jacqueline A., primary, Moran, Michael, primary, Sloan, Phil, primary, Shaw, Richard J., primary, Evans, Mererid, primary, and Jones, Terry M., primary

Published
2023
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10. A better way to prevent surgical complications after laryngectomy

Author

Boyapati, Raghuram, primary, Gill, Tanisha, additional, Ainkaran, Gayatree, additional, Mahendran, Krishantini, additional, Bisase, Brian, additional, Norris, Paul, additional, Davies-Husband, Cameron, additional, Upile, Navdeep, additional, Gulati, Aakshay, additional, and Butler, Daniel, additional

Published
2022
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14. Human papillomavirus (HPV) related Oropharynx Cancer in the United Kingdom – An evolution in the understanding of disease aetiology

Author

Schache, Andrew G, Powell, Ned, Cuschieri, Kate, Robinson, Max, Leary, Sam, Mehanna, Hisham, Rapozo, Davy, Long, Anna, Cubie, Heather, Junor, Elizabeth, Monaghan, Hannah, Harrington, Kevin, Nutting, Christopher M, Schick, Ulrike, Lau, Andy S, Upile, Navdeep, Sheard, Jon, Brougham, Kath, West, Catharine ML, Oguejiofor, Ken, Thomas, Steve, Ness, Andy R, Pring, Miranda, Thomas, Gareth, King, Emma V, McCance, Dennis J, James, Jacqueline A, Moran, Michael, Sloan, Phil, Shaw, Richard J, Evans, Mererid, and Jones, Terry M

Abstract

Substantial increases in oropharyngeal squamous cell carcinoma (OPSCC) incidence have been observed across the developed world and attributed to the rising influence of the Human papillomavirus (HPV) on disease aetiology. This pan-UK multicentre, cross-sectional study aimed to accurately determine the proportion of HPV-positive and -negative OPSCC within the United Kingdom population. Archival tumour-tissue blocks from 1602 patients, previously diagnosed with OPSCC (2002-2011), were collated from eleven centres. HPV status was determined using three validated commercial tests, providing valid data for 1474 cases. Corresponding national incidence data from the same decade were obtained from UK Cancer registries. The overall proportion of OPSCC caused by HPV between 2002-2011 was 51.8% (95% CI:49.3, 54.4) and this remained unchanged throughout the decade (unadjusted risk ratio:1.00 (95% CI:0.99, 1.02). However, over the same period, the incidence of OPSCC in the broader UK population underwent a 2-fold increase (age standardised rate (ASR) 2002:2.1 (95% CI:1.9, 2.2); 2011:4.1(95% CI:4.0, 4.3)). Although the absolute numbers of OPSCC diagnosed within the UK between 2002 and 2011 almost doubled, the proportion of HPV-attributable cases remained static, at approximately 50%. These results provide the first evidence that, in the UK, the rapidly increasing incidence of OPSCC cannot be solely attributable to the influence of HPV. The reasons for this previously undetected parallel increase in HPV-positive and -negative disease warrants further investigation so that appropriate future prevention strategies for both HPV-positive and -negative disease can be implemented.

Published
2016
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15. HPV-Related Oropharynx Cancer in the United Kingdom: An Evolution in the Understanding of Disease Etiology

Author

Schache, Andrew G., primary, Powell, Ned G., additional, Cuschieri, Kate S., additional, Robinson, Max, additional, Leary, Sam, additional, Mehanna, Hisham, additional, Rapozo, Davy, additional, Long, Anna, additional, Cubie, Heather, additional, Junor, Elizabeth, additional, Monaghan, Hannah, additional, Harrington, Kevin J., additional, Nutting, Christopher M., additional, Schick, Ulrike, additional, Lau, Andy S., additional, Upile, Navdeep, additional, Sheard, Jon, additional, Brougham, Kath, additional, West, Catharine M.L., additional, Oguejiofor, Ken, additional, Thomas, Steve, additional, Ness, Andy R., additional, Pring, Miranda, additional, Thomas, Gareth J., additional, King, Emma V., additional, McCance, Dennis J., additional, James, Jacqueline A., additional, Moran, Michael, additional, Sloan, Phil, additional, Shaw, Richard J., additional, Evans, Mererid, additional, and Jones, Terry M., additional

Published
2016
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17. Transoral laser microsurgery for oropharyngeal squamous cell carcinoma: A paradigm shift in therapeutic approach

Author

Wilkie, Mark D., primary, Upile, Navdeep S., additional, Lau, Andrew S., additional, Williams, Stephen P., additional, Sheard, Jon, additional, Helliwell, Tim R., additional, Robinson, Max, additional, Rodrigues, Jennifer, additional, Beemireddy, Krishna, additional, Lewis-Jones, Huw, additional, Hanlon, Rebecca, additional, Husband, David, additional, Shenoy, Aditya, additional, Roland, Nicholas J., additional, Jackson, Shaun R., additional, Bekiroglu, Fazilet, additional, Tandon, Sankalap, additional, Lancaster, Jeffrey, additional, and Jones, Terence M., additional

Published
2016
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