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1. A cell state-specific metabolic vulnerability to GPX4-dependent ferroptosis in glioblastoma

Author

Banu, Matei A, Dovas, Athanassios, Argenziano, Michael G, Zhao, Wenting, Sperring, Colin P, Cuervo Grajal, Henar, Liu, Zhouzerui, Higgins, Dominique MO, Amini, Misha, Pereira, Brianna, Ye, Ling F, Mahajan, Aayushi, Humala, Nelson, Furnari, Julia L, Upadhyayula, Pavan S, Zandkarimi, Fereshteh, Nguyen, Trang TT, Teasley, Damian, Wu, Peter B, Hai, Li, Karan, Charles, Dowdy, Tyrone, Razavilar, Aida, Siegelin, Markus D, Kitajewski, Jan, Larion, Mioara, Bruce, Jeffrey N, Stockwell, Brent R, Sims, Peter A, and Canoll, Peter

Published
2024
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3. ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma

Author

Arrieta, Víctor A, Chen, Andrew X, Kane, J Robert, Kang, Seong Jae, Kassab, Cynthia, Dmello, Crismita, Zhao, Junfei, Burdett, Kirsten B, Upadhyayula, Pavan S, Lee-Chang, Catalina, Shilati, Joseph, Jaishankar, Dinesh, Chen, Li, Gould, Andrew, Zhang, Daniel, Yuan, Jinzhou, Zhao, Wenting, Ling, Xiaoyang, Burks, Jared K, Laffleur, Brice, Amidei, Christina, Bruce, Jeffrey N, Lukas, Rimas V, Yamaguchi, Jonathan T, Cieremans, David, Rothschild, Gerson, Basu, Uttiya, McCord, Matthew, Brat, Daniel J, Zhang, Hui, Cooper, Lee AD, Zhang, Bin, Sims, Peter, Cloughesy, Tim F, Prins, Robert, Canoll, Peter, Stupp, Roger, Heimberger, Amy B, Horbinski, Craig, Iwamoto, Fabio M, Rabadan, Raul, and Sonabend, Adam M

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Rare Diseases, Genetics, Immunotherapy, Cancer, Brain Disorders, Precision Medicine, Brain Cancer, 2.1 Biological and endogenous factors, Glioblastoma, Humans, MAP Kinase Signaling System, Neoplasm Recurrence, Local, Phosphorylation, Oncology and carcinogenesis
Abstract

Only a subset of recurrent glioblastoma (rGBM) responds to anti-PD-1 immunotherapy. Previously, we reported enrichment of BRAF/PTPN11 mutations in 30% of rGBM that responded to PD-1 blockade. Given that BRAF and PTPN11 promote MAPK/ERK signaling, we investigated whether activation of this pathway is associated with response to PD-1 inhibitors in rGBM, including patients that do not harbor BRAF/PTPN11 mutations. Here we show that immunohistochemistry for ERK1/2 phosphorylation (p-ERK), a marker of MAPK/ERK pathway activation, is predictive of overall survival following adjuvant PD-1 blockade in two independent rGBM patient cohorts. Single-cell RNA-sequencing and multiplex immunofluorescence analyses revealed that p-ERK was mainly localized in tumor cells and that high-p-ERK GBMs contained tumor-infiltrating myeloid cells and microglia with elevated expression of MHC class II and associated genes. These findings indicate that ERK1/2 activation in rGBM is predictive of response to PD-1 blockade and is associated with a distinct myeloid cell phenotype.

Published
2021

4. Dietary restriction of cysteine and methionine sensitizes gliomas to ferroptosis and induces alterations in energetic metabolism

Author

Upadhyayula, Pavan S., Higgins, Dominique M., Mela, Angeliki, Banu, Matei, Dovas, Athanassios, Zandkarimi, Fereshteh, Patel, Purvi, Mahajan, Aayushi, Humala, Nelson, Nguyen, Trang T. T., Chaudhary, Kunal R., Liao, Lillian, Argenziano, Michael, Sudhakar, Tejaswi, Sperring, Colin P., Shapiro, Benjamin L., Ahmed, Eman R., Kinslow, Connor, Ye, Ling F., Siegelin, Markus D., Cheng, Simon, Soni, Rajesh, Bruce, Jeffrey N., Stockwell, Brent R., and Canoll, Peter

Published
2023
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5. Benign and Malignant Tumors of the Pineal Region

Author

Upadhyayula, Pavan S., Neira, Justin A., Miller, Michael L., Bruce, Jeffrey N., Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, and Hanaei, Sara, editor

Published
2023
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6. Substituting Gadolinium in Brain MRI Using DeepContrast

Author

Sun, Haoran, Liu, Xueqing, Feng, Xinyang, Liu, Chen, Zhu, Nanyan, Gjerswold-Selleck, Sabrina J., Wei, Hong-Jian, Upadhyayula, Pavan S., Mela, Angeliki, Wu, Cheng-Chia, Canoll, Peter D., Laine, Andrew F., Vaughan, J. Thomas, Small, Scott A., and Guo, Jia

Subjects
Quantitative Biology - Quantitative Methods, Computer Science - Computer Vision and Pattern Recognition, Electrical Engineering and Systems Science - Image and Video Processing
Abstract

Cerebral blood volume (CBV) is a hemodynamic correlate of oxygen metabolism and reflects brain activity and function. High-resolution CBV maps can be generated using the steady-state gadolinium-enhanced MRI technique. Such a technique requires an intravenous injection of exogenous gadolinium based contrast agent (GBCA) and recent studies suggest that the GBCA can accumulate in the brain after frequent use. We hypothesize that endogenous sources of contrast might exist within the most conventional and commonly acquired structural MRI, potentially obviating the need for exogenous contrast. Here, we test this hypothesis by developing and optimizing a deep learning algorithm, which we call DeepContrast, in mice. We find that DeepContrast performs equally well as exogenous GBCA in mapping CBV of the normal brain tissue and enhancing glioblastoma. Together, these studies validate our hypothesis that a deep learning approach can potentially replace the need for GBCAs in brain MRI.

Published
2020

7. Reproducible analysis of disease space via principal components using the novel R package syndRomics.

Author

Torres-Espín, Abel, Chou, Austin, Huie, J Russell, Kyritsis, Nikos, Upadhyayula, Pavan S, and Ferguson, Adam R

Subjects
R package, computational biology, disease pattern discovery, medicine, multivariate analysis, none, nonlinear PCA, principal component analysis pca, syndromics, systems biology, Biochemistry and Cell Biology
Abstract

Biomedical data are usually analyzed at the univariate level, focused on a single primary outcome measure to provide insight into systems biology, complex disease states, and precision medicine opportunities. More broadly, these complex biological and disease states can be detected as common factors emerging from the relationships among measured variables using multivariate approaches. 'Syndromics' refers to an analytical framework for measuring disease states using principal component analysis and related multivariate statistics as primary tools for extracting underlying disease patterns. A key part of the syndromic workflow is the interpretation, the visualization, and the study of robustness of the main components that characterize the disease space. We present a new software package, syndRomics, an open-source R package with utility for component visualization, interpretation, and stability for syndromic analysis. We document the implementation of syndRomics and illustrate the use of the package in case studies of neurological trauma data.

Published
2021

8. Reproducible analysis of disease space via principal components using the novel R package syndRomics

Author

Espín, Abel Torres, Chou, Austin, Huie, Russell, Kyritsis, Nikolaos, Upadhyayula, Pavan S, and Ferguson, Adam

Subjects
Biochemistry and Cell Biology, Biological Sciences, Clinical Research, Good Health and Well Being, Computational Biology, Humans, Principal Component Analysis, Public Health, Software, Syndrome, R package, computational biology, disease pattern discovery, medicine, multivariate analysis, none, nonlinear PCA, principal component analysis pca, syndromics, systems biology, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

Biomedical data are usually analyzed at the univariate level, focused on a single primary outcome measure to provide insight into systems biology, complex disease states, and precision medicine opportunities. More broadly, these complex biological and disease states can be detected as common factors emerging from the relationships among measured variables using multivariate approaches. 'Syndromics' refers to an analytical framework for measuring disease states using principal component analysis and related multivariate statistics as primary tools for extracting underlying disease patterns. A key part of the syndromic workflow is the interpretation, the visualization, and the study of robustness of the main components that characterize the disease space. We present a new software package, syndRomics, an open-source R package with utility for component visualization, interpretation, and stability for syndromic analysis. We document the implementation of syndRomics and illustrate the use of the package in case studies of neurological trauma data.

Published
2021

9. Predictors of six-month inability to return to work in previously employed subjects after mild traumatic brain injury: A TRACK-TBI pilot study.

Author

Yue, John K, Phelps, Ryan Rl, Hemmerle, Debra D, Upadhyayula, Pavan S, Winkler, Ethan A, Deng, Hansen, Chang, Diana, Vassar, Mary J, Taylor, Sabrina R, Schnyer, David M, Lingsma, Hester F, Puccio, Ava M, Yuh, Esther L, Mukherjee, Pratik, Huang, Michael C, Ngwenya, Laura B, Valadka, Alex B, Markowitz, Amy J, Okonkwo, David O, Manley, Geoffrey T, and TRACK-TBI Investigators

Subjects
TRACK-TBI Investigators, Concussion, disability, mild traumatic brain injury, post-concussion syndrome, return to work, Clinical Research, Traumatic Head and Spine Injury, Behavioral and Social Science, Traumatic Brain Injury (TBI), Brain Disorders, Physical Injury - Accidents and Adverse Effects, Neurosciences
Abstract

Return to work (RTW) is an important milestone of mild traumatic brain injury (mTBI) recovery. The objective of this study was to evaluate whether baseline clinical variables, three-month RTW, and three-month postconcussional symptoms (PCS) were associated with six-month RTW after mTBI. Adult subjects from the prospective multicenter Transforming Research and Clinical Knowledge in Traumatic Brain Injury Pilot study with mTBI (Glasgow Coma Scale 13-15) who were employed at baseline, with completed three-and six-month RTW status, and three-month Acute Concussion Evaluation (ACE), were extracted. Univariate and multivariable analyses were performed for six-month RTW, with focus on baseline employment, three-month RTW, and three-month ACE domains (physical, cognitive, sleep, and/or emotional postconcussional symptoms (PCS)). Odds ratios (OR) and 95% confidence intervals [CI] were reported. Significance was assessed at p < 0.05. In 152 patients aged 40.7 ± 15.0years, 72% were employed full-time at baseline. Three- and six-month RTW were 77.6% and 78.9%, respectively. At three months, 59.2%, 47.4%, 46.1% and 31.6% scored positive for ACE physical, cognitive, sleep, and emotional PCS domains, respectively. Three-month RTW predicted six-month RTW (OR = 19.80, 95% CI [7.61-51.52]). On univariate analysis, scoring positive in any three-month ACE domain predicted inability for six-month RTW (OR = 0.10-0.11). On multivariable analysis, emotional symptoms predicted inability to six-month RTW (OR = 0.19 [0.04-0.85]). Subjects who scored positive in all four ACE domains were more likely to be unable to RTW at six months (4 domains: 58.3%, vs. 0-to-3 domains: 9.5%; multivariable OR = 0.09 [0.02-0.33]). Three-month post-injury is an important time point at which RTW status and PCS should be assessed, as both are prognostic markers for six-month RTW. Clinicians should be particularly vigilant of patients who present with emotional symptoms, and patients with symptoms across multiple PCS categories, as these patients are at further risk of inability to RTW and may benefit from targeted evaluation and support.

Published
2021

10. Pediatric Traumatic Brain Injury in the United States: Rural-Urban Disparities and Considerations

Author

Yue, John K, Upadhyayula, Pavan S, Avalos, Lauro N, and Cage, Tene A

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Childhood Injury, Rural Health, Unintentional Childhood Injury, Pediatric, Prevention, Traumatic Head and Spine Injury, Neurosciences, Traumatic Brain Injury (TBI), Health Services, Physical Injury - Accidents and Adverse Effects, Brain Disorders, Clinical Research, Injuries and accidents, Good Health and Well Being, concussion, cost, epidemiology, health disparity, rural, traumatic brain injury, underserved, Psychology, Cognitive Sciences, Applied and developmental psychology, Biological psychology
Abstract

Traumatic brain injury (TBI) remains a primary cause of pediatric morbidity. The improved characterization of healthcare disparities for pediatric TBI in United States (U.S.) rural communities is needed to advance care. The PubMed database was queried using keywords (("brain/head trauma" OR "brain/head injury") AND "rural/underserved" AND "pediatric/child"). All qualifying articles focusing on rural pediatric TBI, including the subtopics epidemiology (N = 3), intervention/healthcare cost (N = 6), and prevention (N = 1), were reviewed. Rural pediatric TBIs were more likely to have increased trauma and head injury severity, with higher-velocity mechanisms (e.g., motor vehicle collisions). Rural patients were at risk of delays in care due to protracted transport times, inclement weather, and mis-triage to non-trauma centers. They were also more likely than urban patients to be unnecessarily transferred to another hospital, incurring greater costs. In general, rural centers had decreased access to mental health and/or specialist care, while the average healthcare costs were greater. Prevention efforts, such as mandating bicycle helmet use through education by the police department, showed improved compliance in children aged 5-12 years. U.S. rural pediatric patients are at higher risk of dangerous injury mechanisms, trauma severity, and TBI severity compared to urban. The barriers to care include protracted transport times, transfer to less-resourced centers, increased healthcare costs, missing data, and decreased access to mental health and/or specialty care during hospitalization and follow-up. Preventative efforts can be successful and will require an improved multidisciplinary awareness and education.

Published
2020

11. B-Cell Lymphoma 2 (Bcl-2) and Regulation of Apoptosis after Traumatic Brain Injury: A Clinical Perspective

Author

Deng, Hansen, Yue, John K, Zusman, Benjamin E, Nwachuku, Enyinna L, Abou-Al-Shaar, Hussam, Upadhyayula, Pavan S, Okonkwo, David O, and Puccio, Ava M

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Pediatric, Brain Disorders, Traumatic Head and Spine Injury, Childhood Injury, Traumatic Brain Injury (TBI), Neurosciences, Hematology, Clinical Research, Rare Diseases, Lymphoma, Cancer, Physical Injury - Accidents and Adverse Effects, Injuries and accidents, Good Health and Well Being, Apoptosis, Biomarkers, Brain Injuries, Traumatic, Humans, Lymphoma, B-Cell, Proto-Oncogene Proteins c-bcl-2, Bcl-2, Bax, Bcl-x(L), apoptosis, programmed cell death, traumatic brain injury, Bcl-xL, General & Internal Medicine, Biomedical and clinical sciences, Health sciences
Abstract

Background and Objectives: The injury burden after head trauma is exacerbated by secondary sequelae, which leads to further neuronal loss. B-cell lymphoma 2 (Bcl-2) is an anti-apoptotic protein and a key modulator of the programmed cell death (PCD) pathways. The current study evaluates the clinical evidence on Bcl-2 and neurological recovery in patients after traumatic brain injury (TBI). Materials and Methods: All studies in English were queried from the National Library of Medicine PubMed database using the following search terms: (B-cell lymphoma 2/Bcl-2/Bcl2) AND (brain injury/head injury/head trauma/traumatic brain injury) AND (human/patient/subject). There were 10 investigations conducted on Bcl-2 and apoptosis in TBI patients, of which 5 analyzed the pericontutional brain tissue obtained from surgical decompression, 4 studied Bcl-2 expression as a biomarker in the cerebrospinal fluid (CSF), and 1 was a prospective randomized trial. Results: Immunohistochemistry (IHC) in 94 adults with severe TBI showed upregulation of Bcl-2 in the pericontusional tissue. Bcl-2 was detected in 36-75% of TBI patients, while it was generally absent in the non-TBI controls, with Bcl-2 expression increased 2.9- to 17-fold in TBI patients. Terminal deoxynucleotidyl transferase-mediated biotinylated dUTP nick-end labeling (TUNEL) positivity for cell death was detected in 33-73% of TBI patients. CSF analysis in 113 TBI subjects (90 adults, 23 pediatric patients) showed upregulation of Bcl-2 that peaked on post-injury day 3 and subsequently declined after day 5. Increased Bcl-2 in the peritraumatic tissue, rising CSF Bcl-2 levels, and the variant allele of rs17759659 are associated with improved mortality and better outcomes on the Glasgow Outcome Score (GOS). Conclusions: Bcl-2 is upregulated in the pericontusional brain and CSF in the acute period after TBI. Bcl-2 has a neuroprotective role as a pro-survival protein in experimental models, and increased expression in patients can contribute to improvement in clinical outcomes. Its utility as a biomarker and therapeutic target to block neuronal apoptosis after TBI warrants further evaluation.

Published
2020

12. The Role of Blood Biomarkers for Magnetic Resonance Imaging Diagnosis of Traumatic Brain Injury

Author

Yue, John K, Upadhyayula, Pavan S, Avalos, Lauro N, Deng, Hansen, and Wang, Kevin KW

Subjects
Traumatic Brain Injury (TBI), Traumatic Head and Spine Injury, Biomedical Imaging, Physical Injury - Accidents and Adverse Effects, Brain Disorders, Neurosciences, Clinical Research, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis, 4.1 Discovery and preclinical testing of markers and technologies, Area Under Curve, Biomarkers, Brain Injuries, Traumatic, Humans, Magnetic Resonance Imaging, ROC Curve, blood-based biomarkers, diagnosis, magnetic resonance imaging, traumatic brain injury, General & Internal Medicine
Abstract

Background and Objectives: The annual global incidence of traumatic brain injury (TBI) is over 10 million. An estimated 29% of TBI patients with negative computed tomography (CT-) have positive magnetic resonance imaging (MRI+) findings. Judicious use of serum biomarkers with MRI may aid in diagnosis of CT-occult TBI. The current manuscript aimed to evaluate the diagnostic, therapeutic and risk-stratification utility of known biomarkers and intracranial MRI pathology. Materials and Methods: The PubMed database was queried with keywords (plasma OR serum) AND (biomarker OR marker OR protein) AND (brain injury/trauma OR head injury/trauma OR concussion) AND (magnetic resonance imaging/MRI) (title/abstract) in English. Seventeen articles on TBI biomarkers and MRI were included: S100 calcium-binding protein B (S100B; N = 6), glial fibrillary acidic protein (GFAP; N = 3), GFAP/ubiquitin carboxyl-terminal hydrolase-L1 (UCH-L1; N = 2), Tau (N = 2), neurofilament-light (NF-L; N = 2), alpha-synuclein (N = 1), and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor peptide (AMPAR; N = 1). Results: Acute GFAP distinguished CT-/MRI+ from CT-/MRI- (AUC = 0.777, 0.852 at 9-16 h). GFAP discriminated CT-/diffuse axonal injury (DAI+) from controls (AUC = 0.903). Tau correlated directly with number of head strikes and inversely with white matter fractional anisotropy (FA), and a cutoff > 1.5 pg/mL discriminated between DAI+ and DAI- (sensitivity = 74%/specificity = 69%). NF-L had 100% discrimination of DAI in severe TBI and correlated with FA. Low alpha-synuclein was associated with poorer functional connectivity. AMPAR cutoff > 0.4 ng/mL had a sensitivity of 91% and a specificity of 92% for concussion and was associated with minor MRI findings. Low/undetectable S100B had a high negative predictive value for CT/MRI pathology. UCH-L1 showed no notable correlations with MRI. Conclusions: An acute circulating biomarker capable of discriminating intracranial MRI abnormalities is critical to establishing diagnosis for CT-occult TBI and can triage patients who may benefit from outpatient MRI, surveillance and/or follow up with TBI specialists. GFAP has shown diagnostic potential for MRI findings such as DAI and awaits further validation. Tau shows promise in detecting DAI and disrupted functional connectivity. Candidate biomarkers should be evaluated within the context of analytical performance of the assays used, as well as the post-injury timeframe for blood collection relative to MRI abnormalities.

Published
2020

13. Management of asynchronous multifocal adult glioblastoma with loss of BRAFV600E -mutant clonality: a case report.

Author

Haile, Hannah, Upadhyayula, Pavan S., Karlovich, Esma, Sisti, Michael B., Gill, Brian J. A., and Donovan, Laura E.

Subjects
*MEDICAL sciences, *GLIOBLASTOMA multiforme, *GLIOMAS, *SMALL molecules, *SURGICAL excision
Abstract

Glioblastoma (GBM) classification involves a combination of histological and molecular signatures including IDH1/2 mutation, TERT promoter mutation, and EGFR amplification. Non-canonical mutations such as BRAFV600E, found in 1–2% of GBMs, activate the MEK-ERK signaling pathway. This mutation can be targeted by small molecule inhibitors, offering therapeutic potential for GBM. In this case report, we describe the management of a 67-year-old male with BRAFV600E -mutant GBM, who experienced both local clonal and distant non-clonal BRAFV600E -mutant recurrences. Initial treatment involved surgical resection followed by radiotherapy and temozolomide (TMZ). Subsequent recurrences were managed with re-resection and dabrafenib/trametinib combination therapy. Notably, a new, non-clonal BRAFV600E -negative tumor developed in a distant location, highlighting the challenge of clonal evolution and resistance in GBM management. The patient's disease ultimately progressed despite multiple lines of therapy, including targeted inhibition. Identifying mechanisms of resistance and tailoring flexible treatment approaches are essential for advancing outcomes in BRAFV600E -mutant GBM. This case emphasizes the value of molecular profiling in personalizing treatment for patients with multifocal disease. The evolving nature of these tumors requires persistent clinical monitoring and treatment adjustments based on tissue diagnostics. [ABSTRACT FROM AUTHOR]

Published
2025
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14. Anterior Versus Transforaminal Lumbar Interbody Fusion: Perioperative Risk Factors and 30-Day Outcomes.

Author

Upadhyayula, Pavan S, Curtis, Erik I, Yue, John K, Sidhu, Nikki, and Ciacci, Joseph D

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Rehabilitation, Patient Safety, Cardiovascular, 6.4 Surgery, Evaluation of treatments and therapeutic interventions, anterior lumbar interbody fusion, ACS-NSQIP, posterior lumbar interbody fusion, lumbar spine surgery, early complications, surgical outcomes, transforaminal lumbar interbody fusion, degenerative disc disease, low back pain, operation time, Neurosciences, Clinical sciences
Abstract

BackgroundOperative management of lower back pain often necessitates anterior lumbar interbody fusion (ALIF) or transforaminal lumbar interbody fusion (TLIF). Specific pathoanatomic advantages and indications exist for both approaches, and few studies to date have characterized comparative early outcomes.MethodsAdult patients undergoing elective ALIF or TLIF operations were abstracted from the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) years 2011-2014. Univariate analyses were performed by surgery cohort for each outcome and adjusted for demographic/clinical variables (age ≥ 65, sex, race, body mass index, American Society of Anesthesiologists physical classification score, functional status, inpatient/outpatient status, smoking, hypertension, Charlson Comorbidity Index) using multivariable regression. Means, standard errors, mean differences (B), odds ratios (ORs), and associated 95% confidence intervals (CIs) are reported. Significance was assessed at P < .05.ResultsOf 8263 subjects (ALIF: 4325, TLIF: 3938), ALIF subjects were younger, less obese, less physically impaired, and had significantly lower rates of hypertension, diabetes, coagulopathy, and previous cardiac surgery. On multivariable analysis, ALIF associated with shorter operative time (B = -11.80 minutes, 95% CI [-16.48, -7.12]; P < .001). Transforaminal lumbar interbody fusion was associated with increased incidence of urinary tract infections (UTIs; OR = 1.57, 95% CI [1.10, 2.26]; P = .013) and of blood transfusions (OR = 1.19, 95% CI [1.04, 1.37]; P = .012). Multivariate analysis also demonstrated TLIF associated with shorter hospital length of stay (B = -0.27 days, 95% CI [-0.54, -0.01]; P = .041), and fewer cases of pneumonia (OR = 0.55, 95% CI [0.32, 0.94]; P = .029) and prolonged ventilator dependency (OR = 0.33, 95% CI [0.12, 0.84]; P = .021).ConclusionsComparatively, ALIF patients experienced decreased operative time and decreased incidence of postoperative UTIs and blood transfusions. Anterior lumbar interbody fusion patients were more likely to suffer postoperative pulmonary complications and longer hospital stays. Our data support the notion that both anterior and transforaminal surgical approaches perform comparably in context of 30-day perioperative outcomes.

Published
2018

15. Apolipoprotein E Epsilon 4 Genotype, Mild Traumatic Brain Injury, and the Development of Chronic Traumatic Encephalopathy.

Author

Deng, Hansen, Ordaz, Angel, Upadhyayula, Pavan S, Gillis-Buck, Eva M, Suen, Catherine G, Melhado, Caroline G, Mohammed, Nebil, Lam, Troy, and Yue, John K

Subjects
apolipoprotein E, chronic traumatic encephalopathy, concussion, genetic risk factors, mild traumatic brain injury, neurodegenerative disorders, Neurosciences, Brain Disorders, Neurodegenerative, Injury - Traumatic brain injury, Acquired Cognitive Impairment, Injury - Trauma - (Head and Spine), Injury (total) Accidents/Adverse Effects
Abstract

The annual incidence of mild traumatic brain injury (MTBI) is 3.8 million in the USA with 10⁻15% experiencing persistent morbidity beyond one year. Chronic traumatic encephalopathy (CTE), a neurodegenerative disease characterized by accumulation of hyperphosphorylated tau, can occur with repetitive MTBI. Risk factors for CTE are challenging to identify because injury mechanisms of MTBI are heterogeneous, clinical manifestations and management vary, and CTE is a postmortem diagnosis, making prospective studies difficult. There is growing interest in the genetic influence on head trauma and development of CTE. Apolipoprotein epsilon 4 (APOE-ε4) associates with many neurologic diseases, and consensus on the ε4 allele as a risk factor is lacking. This review investigates the influence of APOE-ε4 on MTBI and CTE. A comprehensive PubMed literature search (1966 to 12 June 2018) identified 24 unique reports on the topic (19 MTBI studies: 8 athletic, 5 military, 6 population-based; 5 CTE studies: 4 athletic and military, 1 leucotomy group). APOE-ε4 genotype is found to associate with outcomes in 4/8 athletic reports, 3/5 military reports, and 5/6 population-based reports following MTBI. Evidence on the association between APOE-ε4 and CTE from case series is equivocal. Refining modalities to aid CTE diagnosis in larger samples is needed in MTBI.

Published
2018

17. Subacute Sclerosing Panencephalitis of the Brainstem as a Clinical Entity.

Author

Upadhyayula, Pavan S, Yang, Jason, Yue, John K, and Ciacci, Joseph D

Subjects
brainstem, measles, neurodegeneration, neuroimaging, subacute sclerosing panencephalitis
Abstract

Subacute sclerosing panencephalitis (SSPE) is a rare progressive neurological disorder of early adolescence caused by persistent infection of the measles virus, which remains prevalent worldwide despite an effective vaccine. SSPE is a devastating disease with a characteristic clinical course in subcortical white matter; however, atypical presentations of brainstem involvement may be seen in rare cases. This review summarizes reports to date on brainstem involvement in SSPE, including the clinical course of disease, neuroimaging presentations, and guidelines for treatment. A comprehensive literature search was performed for English-language publications with keywords "subacute sclerosing panencephalitis" and "brainstem" using the National Library of Medicine PubMed database (March 1981-September 2017). Eleven articles focusing on SSPE of the brainstem were included. Predominant brainstem involvement remains uncharacteristic of SSPE, which may lead to misdiagnosis and poor outcome. A number of case reports have demonstrated brainstem involvement associated with other intracranial lesions commonly presenting in later SSPE stages (III and IV). However, brainstem lesions can appear in all stages, independent of higher cortical structures. The varied clinical presentations complicate diagnosis from a neuroimaging perspective. SSPE of the brainstem is a rare but important clinical entity. It may present like canonical SSPE or with unique clinical features such as absence seizures and pronounced ataxia. While SSPE generally progresses to the brainstem, it can also begin with a primary focus of infection in the brainstem. Awareness of varied SSPE presentations can aid in early diagnosis as well as guide management and treatment.

Published
2017

18. Selective Serotonin Reuptake Inhibitors for Treating Neurocognitive and Neuropsychiatric Disorders Following Traumatic Brain Injury: An Evaluation of Current Evidence.

Author

Yue, John K, Burke, John F, Upadhyayula, Pavan S, Winkler, Ethan A, Deng, Hansen, Robinson, Caitlin K, Pirracchio, Romain, Suen, Catherine G, Sharma, Sourabh, Ferguson, Adam R, Ngwenya, Laura B, Stein, Murray B, Manley, Geoffrey T, and Tarapore, Phiroz E

Subjects
cognition, depression, meta-analysis, postconcussive disorder, selective serotonin reuptake inhibitor, sleep disturbance, traumatic brain injury, Injury - Traumatic brain injury, Clinical Research, Brain Disorders, Injury (total) Accidents/Adverse Effects, Depression, Mental Health, Neurosciences, Injury - Trauma - (Head and Spine), Behavioral and Social Science, Clinical Trials and Supportive Activities, 6.1 Pharmaceuticals, 6.6 Psychological and behavioural, Mental health, Psychology, Cognitive Sciences
Abstract

The prevalence of neuropsychiatric disorders following traumatic brain injury (TBI) is 20%-50%, and disorders of mood and cognition may remain even after recovery of neurologic function is achieved. Selective serotonin reuptake inhibitors (SSRI) block the reuptake of serotonin in presynaptic cells to lead to increased serotonergic activity in the synaptic cleft, constituting first-line treatment for a variety of neurocognitive and neuropsychiatric disorders. This review investigates the utility of SSRIs in treating post-TBI disorders. In total, 37 unique reports were consolidated from the Cochrane Central Register and PubMed (eight randomized-controlled trials (RCTs), nine open-label studies, 11 case reports, nine review articles). SSRIs are associated with improvement of depressive but not cognitive symptoms. Pooled analysis using the Hamilton Depression Rating Scale demonstrate a significant mean decrease of depression severity following sertraline compared to placebo-a result supported by several other RCTs with similar endpoints. Evidence from smaller studies demonstrates mood improvement following SSRI administration with absent or negative effects on cognitive and functional recovery. Notably, studies on SSRI treatment effects for post-traumatic stress disorder after TBI remain absent, and this represents an important direction of future research. Furthermore, placebo-controlled studies with extended follow-up periods and concurrent biomarker, neuroimaging and behavioral data are necessary to delineate the attributable pharmacological effects of SSRIs in the TBI population.

Published
2017

21. Transferrin Receptor Is a Specific Ferroptosis Marker

Author

Feng, Huizhong, Schorpp, Kenji, Jin, Jenny, Yozwiak, Carrie E., Hoffstrom, Benjamin G., Decker, Aubrianna M., Rajbhandari, Presha, Stokes, Michael E., Bender, Hannah G., Csuka, Joleen M., Upadhyayula, Pavan S., Canoll, Peter, Uchida, Koji, Soni, Rajesh K., Hadian, Kamyar, and Stockwell, Brent R.

Published
2020
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22. Circadian variability of the initial Glasgow Coma Scale score in traumatic brain injury patients.

Author

Yue, John K, Robinson, Caitlin K, Winkler, Ethan A, Upadhyayula, Pavan S, Burke, John F, Pirracchio, Romain, Suen, Catherine G, Deng, Hansen, Ngwenya, Laura B, Dhall, Sanjay S, Manley, Geoffrey T, and Tarapore, Phiroz E

Subjects
CAD, coronary artery disease, CCI, Charlson Comorbidity Index, CI, confidence interval, COPD, chronic obstructive pulmonary disease, CRSD, circadian rhythm sleep disorder, Circadian, ED, emergency department, Emergency department, GABA, gamma-aminobutyric acid, GCS, Glasgow Coma Scale, Glasgow Coma Scale, Hospital admission, ICD-9, International Classification of Diseases, 9th Revision, ICU, intensive care unit, IQR, interquartile range, ISS, injury severity score, MVA, motor vehicle accident, NSP, National Sample Program, NTDB, National Trauma Data Bank, Neurologic deficit, OR, odds ratio, REM, rapid eye movement, RHT, reticulohypothalamic tract, SCN, suprachiasmatic nucleus, SD, standard deviation, SE, standard error, TBI, traumatic brain injury, Traumatic brain injury, Brain Disorders, Traumatic Brain Injury (TBI), Neurosciences, Physical Injury - Accidents and Adverse Effects, Clinical Research, Traumatic Head and Spine Injury, Injuries and accidents, Good Health and Well Being
Abstract

IntroductionThe Glasgow Coma Scale (GCS) score is the primary method of assessing consciousness after traumatic brain injury (TBI), and the clinical standard for classifying TBI severity. There is scant literature discerning the influence of circadian rhythms or emergency department (ED) arrival hour on this important clinical tool.MethodsRetrospective cohort analysis of adult patients suffering blunt TBI using the National Sample Program of the National Trauma Data Bank, years 2003-2006. ED arrival GCS score was characterized by midday (10 a.m.-4 p.m.) and midnight (12 a.m.-6 a.m.) cohorts (N=24548). Proportions and standard errors are reported for descriptive data. Multivariable regressions using odds ratios (OR), mean differences (B), and their associated 95% confidence intervals [CI] were performed to assess associations between ED arrival hour and GCS score. Statistical significance was assessed at p

Published
2017

24. Publisher Correction: ERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma

Author

Arrieta, Víctor A., Chen, Andrew X., Kane, J. Robert, Kang, Seong Jae, Kassab, Cynthia, Dmello, Crismita, Zhao, Junfei, Burdett, Kirsten B., Upadhyayula, Pavan S., Lee-Chang, Catalina, Shilati, Joseph, Jaishankar, Dinesh, Chen, Li, Gould, Andrew, Zhang, Daniel, Yuan, Jinzhou, Zhao, Wenting, Ling, Xiaoyang, Burks, Jared K., Laffleur, Brice, Amidei, Christina, Bruce, Jeffrey N., Lukas, Rimas V., Yamaguchi, Jonathan T., Cieremans, David, Rothschild, Gerson, Basu, Uttiya, McCord, Matthew, Brat, Daniel J., Zhang, Hui, Cooper, Lee A. D., Zhang, Bin, Sims, Peter, Cloughesy, Tim F., Prins, Robert, Canoll, Peter, Stupp, Roger, Heimberger, Amy B., Horbinski, Craig, Iwamoto, Fabio M., Rabadan, Raul, and Sonabend, Adam M.

Published
2022
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27. Association of MGMT Promotor Methylation With Survival in Low-grade and Anaplastic Gliomas After Alkylating Chemotherapy

Author

Kinslow, Connor J., primary, Mercurio, Ann, additional, Kumar, Prashanth, additional, Rae, Ali I., additional, Siegelin, Markus D., additional, Grinband, Jack, additional, Taparra, Kekoa, additional, Upadhyayula, Pavan S., additional, McKhann, Guy M., additional, Sisti, Michael B., additional, Bruce, Jeffrey N., additional, Canoll, Peter D., additional, Iwamoto, Fabio M., additional, Kachnic, Lisa A., additional, Yu, James B., additional, Cheng, Simon K., additional, and Wang, Tony J. C., additional

Published
2023
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29. A cell state specific metabolic vulnerability to GPX4-dependent ferroptosis in glioblastoma

Author

Banu, Matei A., primary, Dovas, Athanassios, additional, Argenziano, Michael G., additional, Zhao, Wenting, additional, Grajal, Henar Cuervo, additional, Higgins, Dominique M.O., additional, Sperring, Colin P., additional, Pereira, Brianna, additional, Ye, Ling F., additional, Mahajan, Aayushi, additional, Humala, Nelson, additional, Furnari, Julia L., additional, Upadhyayula, Pavan S., additional, Zandkarimi, Fereshteh, additional, Nguyen, Trang T. T., additional, Wu, Peter B., additional, Hai, Li, additional, Karan, Charles, additional, Razavilar, Aida, additional, Siegelin, Markus D., additional, Kitajewski, Jan, additional, Bruce, Jeffrey N., additional, Stockwell, Brent R., additional, Sims, Peter A., additional, and Canoll, Peter D., additional

Published
2023
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31. Chronic convection-enhanced delivery of topotecan for patients with recurrent glioblastoma: a first-in-patient, single-centre, single-arm, phase 1b trial

Author

Spinazzi, Eleonora F, primary, Argenziano, Michael G, additional, Upadhyayula, Pavan S, additional, Banu, Matei A, additional, Neira, Justin A, additional, Higgins, Dominique M O, additional, Wu, Peter B, additional, Pereira, Brianna, additional, Mahajan, Aayushi, additional, Humala, Nelson, additional, Al-Dalahmah, Osama, additional, Zhao, Wenting, additional, Save, Akshay V, additional, Gill, Brian J A, additional, Boyett, Deborah M, additional, Marie, Tamara, additional, Furnari, Julia L, additional, Sudhakar, Tejaswi D, additional, Stopka, Sylwia A, additional, Regan, Michael S, additional, Catania, Vanessa, additional, Good, Laura, additional, Zacharoulis, Stergios, additional, Behl, Meenu, additional, Petridis, Petros, additional, Jambawalikar, Sachin, additional, Mintz, Akiva, additional, Lignelli, Angela, additional, Agar, Nathalie Y R, additional, Sims, Peter A, additional, Welch, Mary R, additional, Lassman, Andrew B, additional, Iwamoto, Fabio M, additional, D’Amico, Randy S, additional, Grinband, Jack, additional, Canoll, Peter, additional, and Bruce, Jeffrey N, additional

Published
2022
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34. 182 Predictors of Six-Month Inability to Return to Work in Previously Employed Subjects After Mild Traumatic Brain Injury: A TRACK-TBI Pilot Study

Author

Yue, John K., primary, Phelps, Ryan R. L., additional, Hemmerle, Debra P., additional, Upadhyayula, Pavan S., additional, Winkler, Ethan A., additional, Deng, Hansen, additional, Chang, Diana, additional, Vassar, Mary, additional, Taylor, Sabrina, additional, Schnyer, David, additional, Lingsma, Hester F., additional, Puccio, Ava, additional, Yuh, Esther, additional, Mukherjee, Pratik, additional, Huang, Michael C., additional, Ngwenya, Laura B., additional, Valadka, Alex B., additional, Markowitz, Amy, additional, Okonkwo, David O., additional, and Manley, Geoffrey T., additional

Published
2022
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35. Treatment of Recurrent Glioblastoma by Chronic Convection-Enhanced Delivery of Topotecan

Author

Spinazzi, Eleonora F., primary, Argenziano, Michael G., additional, Upadhyayula, Pavan S., additional, Banu, Matei A., additional, Neira, Justin A., additional, Higgins, Dominique M.O., additional, Wu, Peter B., additional, Pereira, Brianna, additional, Mahajan, Aayushi, additional, Humala, Nelson, additional, Al-Dalahmah, Osama, additional, Zhao, Wenting, additional, Save, Akshay V., additional, Boyett, Deborah M., additional, Marie, Tamara, additional, Furnari, Julia L, additional, Sudhakar, Tejaswi D., additional, Stopka, Sylwia A., additional, Regan, Michael S., additional, Catania, Vanessa, additional, Good, Laura, additional, Behl, Meenu, additional, Jambawalikar, Sachin, additional, Mintz, Akiva, additional, Lignelli, Angela, additional, Agar, Nathalie Y.R., additional, Sims, Peter A., additional, Welch, Mary, additional, Lassman, Andrew, additional, Iwamoto, Fabio, additional, D’Amico, Randy S., additional, Grinband, Jack, additional, Canoll, Peter, additional, and Bruce, Jeffrey N., additional

Published
2021
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37. Elderly traumatic central cord syndrome in the USA: a review of management and outcomes

Author

PHELPS, Ryan R., primary, YUE, John K., additional, TSOLINAS, Rachel E., additional, DENG, Hansen, additional, RIOS, Jennifer, additional, UPADHYAYULA, Pavan S., additional, DALLE ORE, Cecilia L., additional, LEE, Young M., additional, SUEN, Catherine G., additional, BURKE, John F., additional, WINKLER, Ethan A., additional, and DHALL, Sanjay S., additional

Published
2021
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39. Focused Ultrasound-Mediated Blood-Brain Barrier Opening Increases Delivery and Efficacy of Etoposide for Glioblastoma Treatment

Author

Wei, Hong-Jian, primary, Upadhyayula, Pavan S., additional, Pouliopoulos, Antonios N., additional, Englander, Zachary K., additional, Zhang, Xu, additional, Jan, Chia-Ing, additional, Guo, Jia, additional, Mela, Angeliki, additional, Zhang, Zhiguo, additional, Wang, Tony J.C., additional, Bruce, Jeffrey N., additional, Canoll, Peter D., additional, Feldstein, Neil A., additional, Zacharoulis, Stergios, additional, Konofagou, Elisa E., additional, and Wu, Cheng-Chia, additional

Published
2021
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43. Basal impulses: findings from the last twenty years on impulsivity and reward pathways using deep brain stimulation

Author

UPADHYAYULA, Pavan S., primary, RENNERT, Robert C., additional, MARTIN, Joel R., additional, YUE, John K., additional, YANG, Jason, additional, GILLIS-BUCK, Eva M., additional, SIDHU, Nikki, additional, CHEUNG, Christopher K., additional, LEE, Anthony T., additional, HOSHIDE, Reid R., additional, and CIACCI, Joseph D., additional

Published
2021
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46. Dietary Alteration of Cysteine and Methionine Sensitizes Gliomas to Ferroptosis Inducing Agents and Radiation

Author

Upadhyayula, Pavan S, primary, Higgins, Dominique, additional, Dovas, Athanassios, additional, Mela, Angeliki, additional, Chaudhaury, Kunal, additional, Mahajan, Aayushi, additional, Humala, Nelson, additional, Sudhakar, Tejaswi, additional, Kinslow, Connor, additional, Stockwell, Brent, additional, Canoll, Peter D, additional, and Bruce, Jeffrey N, additional

Published
2020
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47. Successful Clinical Trial of Chronic Convection-Enhanced Drug Delivery Via an Implanted Pump

Author

Bruce, Jeffrey N, primary, Spinazzi, Eleonora F, additional, Lassman, Andrew, additional, Iwamoto, Fabio, additional, Welch, Mary, additional, Banu, Matei A, additional, Argenziano, Michael, additional, Upadhyayula, Pavan S, additional, Lignelli, Angela, additional, Grinband, Jack, additional, Sims, Peter, additional, D’Amico, Randy, additional, and Canoll, Peter D, additional

Published
2020
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48. Substituting Gadolinium in Brain MRI Using DeepContrast

Author

Sun, Haoran, primary, Liu, Xueqing, additional, Feng, Xinyang, additional, Liu, Chen, additional, Zhu, Nanyan, additional, Gjerswold-Selleck, Sabrina J., additional, Wei, Hong-Jian, additional, Upadhyayula, Pavan S., additional, Mela, Angeliki, additional, Wu, Cheng-Chia, additional, Canoll, Peter D., additional, Laine, Andrew F., additional, Vaughan, J. Thomas, additional, Small, Scott A., additional, and Guo, Jia, additional

Published
2020
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50. Contributors

Author

Aarabi, Bizhan, Abbott, Rick, Abd-El-Barr, Muhammad M., Abel, Taylor J., Abou-Al-Shaar, Hussam, Acar, Feridun, Achey, Rebecca L., Ackerman, Laurie L., Adappa, Nithin D., Adelson, P. David, Agarwal, Nitin, Aguirre-Padilla, David H., Ahluwalia, Manmeet S., Ahmad, Shahjehan, Ahmed, A. Karim, Ahmed, Raheel, Aisiku, Imoigele P., Akbar, Muhammad A., Akram, Harith, Alaraj, Ali, Albrecht, Jennifer S., Albuquerque, Felipe C., Alexander, Michael J., Alexandrov, Andrei V., Alexopoulos, Andreas V., Ali, Zarina S., Al-Khalili, Kenan, Al-Mefty, Ossama, Al-Mefty, Rami O., Alnahhas, Iyad, Alrobaian, Malek, Al-Saiegh, Fadi, Alterman, Ron L., Altshuler, David B., Amenta, Peter S., Ames, Christopher P., Amin-Hanjani, Sepideh, Ammirati, Mario, Andaluz, Norberto, Anderson, Richard C.E., Andrade, Pablo, Ares, William J., Arle, Jeffrey E., Arnaout, Omar, Arnold, Paul M., Assina, Rachid, Aszmann, Oskar C., Attenello, Frank J., III, Attia, Albert, Avellino, Anthony M., Awad, Issam A., Ayantayo, Temitayo O., Bader, Edward R., Badhiwala, Jetan H., Baehring, Joachim M., Bagic´, Anto I., Bagley, Stephen J., Bai, Michael Y., Bailes, Julian E., Bain, Mark, Baker, Turner, Ball, Perry A., Ballester, Leomar Y., Balu, Ramani, Ban, Vin Shen, Barak, Tanyeri, Baranoski, Jacob F., Barbaro, Nicholas M., Barber, Sean M., Barker, Frederick G., II, Barnett, Gene H., Barone, Constance M., Barrow, Daniel Louis, Basma, Jaafar, Batchelor, Tracy T., Batjer, H. Hunt, Beattie, Michael S., Beaumont, Andrew, Beaumont, Thomas L., Bederson, Joshua B., Belani, Puneet, Belzberg, Allan J., Benet, Arnau, Ben-Haim, Sharona, Berenstein, Alejandro, Berga, Sarah L., Berger, Mitchel S., Bergsneider, Marvin, Bernstock, Joshua D., Bhatia, Sanjay, Bi, Wenya Linda, Bigder, Mark G., Bijlenga, Philippe, Bingaman, William, Birk, Harjus S., Bishop, Allen T., Blakeley, Jaishri O., Blomstedt, Patric, Blue, Rachel, Blumenthal, Scott, Boaro, Alessandro, Boddu, James V., Bohnen, Angela, Bok, Arnold P., Boone, Myles D., Boop, Frederick A., Boszczyk, Bronek M., Bowyer, Susan M., Brahimaj, Bledi C., Brem, Henry, Brem, Steven, Bresnahan, Jacqueline C., Brinjikji, Waleed, Brinkmann, Benjamin H., Brînzeu, Andrei, Britz, Gavin W., Brockmeyer, Douglas L., Brown, Desmond A., Brown, Justin M., Brown, Matthew T., Brown, Robert D., Jr., Bruce, Jeffrey N., Bruckman, Karl C., Bruhat, Alexis, Brunstrom-Hernandez, Janice E., Brunswick, Andrew, Bruzek, Amy K., Buchanan, Ian A., Budohoski, Karol P., Buell, Thomas J., Büki, András, Bunevicius, Adomas, Burchiel, Kim J., Bydon, Mohamad, Byrne, Richard W., Cabrejo, Raysa, Cabrilo, Ivan, Cahill, Daniel P., Caplan, Justin M., Carlson, Andrew P., Carrión-Penagos, Julián, Carroll, Benjamin W., Cascino, Gregory D., Castaneyra-Ruiz, Leandro, Castinetti, Frederic, Cavalcanti, Daniel D., Cawley, C. Michael, Cernak, Ibolja, Cetas, Justin S., Chan, Michael D., Ka-Ying Chan, Vivien, Chang, Chih-Chang, Chang, Louis, Chang, Steven D., Charbel, Fady T., Charest-Morin, Raphaële, Chari, Aswin, Chaudhary, Navjot, Chauvel, Patrick, Chen, Kevin S., Chen, Liang, Cheng, Joseph, Cherian, Jacob, Cheung, Kenneth M.C., Cheyuo, Cletus, Chiang, Veronica L., Chiarelli, Peter A., Chiocca, E. Antonio, Chitale, Rohan V., Cho, Catherine, Choi, Heejung, Chou, Dean, Christian, Cindy W., Christiansen, Peter A., Church, Ephraim W., Clarke, Jennifer L., Cleary, Daniel R., Clune, James E., Cohen, Justin D., Cohen-Inbar, Or, Colasanti, Roberto, Collins, John M., Comair, Youssef G., Conner, Andrew K.P., Connolly, E. Sander, Jr., Cooper, Jared B., Corcos, Daniel Montie, Coric, Domagoj, Costa, Anthony B., Couldwell, William T., Crino, Peter B., Crofton, Andrew R., Cullen, D. Kacy, Curt, Armin, Dacey, Ralph G., Jr., Daci, Rrita, Dailey, Andrew T., D’Alessandris, Quintino Giorgio, Damisah, Eyiyemisi C., Daniels, David J., Das, Sunit, Davanzo, Justin R., David, Carlos A., David, David J., Davidson, Benjamin, Davis, Gavin A., Day, Arthur L., Dea, Nicolas, De Donato, Giuseppe, Deiner, Stacie, De la Garza, Carlos, Delavari, Nader, Del Brutto, Oscar H., Delman, Bradley N., DeLong, Mahlon R., DeMonte, Franco, de Oliveira, Evandro, Derman, Peter B., Desai, Arati, Deshpande, Krutika, Diaz, Michele, Diaz-Arrastia, Ramon R., DiGiorgio, Anthony M., DiLuna, Michael L., DiMeco, Francesco, Dlouhy, Brian J., Doğruel, Yücel, Donahue, Joseph H., Donoho, Daniel A., Doshi, Amish H., Dreier, Jens P., Driver, Joseph, Drofa, Alexander, Ducruet, Andrew F., Duffau, Hugues, Duhaime, Ann-Christine, Dumont, Aaron S., Duncan, John S., Dunn, Gavin P., Dunn, Ian F., Eberwine, James H., Eckardt, Gerald W., Edem, Idara J., Edwards, Michael S.B., Egemen, Emrah, Eisenbarth, Rachel, Eisenberg, Howard, Elder, J. Bradley, Elhammady, Mohamed Samy, Elias, W. Jeffrey, Ellingson, Benjamin M., Ellis, Jason A., Elswick, Clay M., Emch, Todd M., Emerson, Samuel, Ene, Chibawanye I., Englot, Dario J., Erdman, John H., III, Eskandari, Ramin, Essayed, Walid Ibn, Everson, Richard G., Fadul, Camilo E., Fan, Yi, Farina, Dario, Farrell, Christopher J., Feghali, James, Fehlings, Michael G., Fehnel, Katie Pricola, Feigin, Valery L., Feldman, Eva L., Feldman, Michael J., Feldstein, Neil, Fenno, Lief E., Ferguson, Adam R., Feroze, Abdullah H., Fessler, Richard G., Filler, Aaron G., Findlay, J. Max, Finn, Michael A., Finnell, Richard H., Fisher, Charles G., Flamm, Eugene S., Flanders, Tracy M., Flemming, Kelly D., Flores-Sarnat, Laura, Follett, Kenneth A., Fontes, Ricardo B.V., Ford, Paul J., Foreman, Brandon P., Foreman, Paul M., Fornoff, Linden E., Fouda, Mohammed A., Foyouzi, Nastaran, Franco, Daniel, Franzini, Andrea, Fridley, Jared S., Friedlander, Robert M., Frisoli, Fabio A., Fry, Donald E., Gregory Fu, Kai-Ming, Fujita, Naohide, Fulbright, Robert K., Fulkerson, Daniel H., Fuller, Gregory N., Fusco, Matthew R., Galanopoulou, Aristea S., Gallagher, Gary W., Galvan, Adriana, Gander, Phillip E., Gandhi, Chirag D., Gao, Guoyi, Garcia, Hector H., García, Paul S., Gardner, Paul A., Gardner, Raquel C., Garzon-Muvdi, Tomas, Gavin, Cormac G., Gea-Banacloche, Juan C., George, Timothy M., Georgoulis, George D., Gerard, Carter S., Gerety, Patrick A., Gerszten, Kristina, Gerszten, Peter C., Ghaith, Abdul Karim, Ghatan, Saadi, Ghobrial, George M., Ghogawala, Zoher, Ghosh, Chaitali, Giacino, Joseph T., Giacobbe, Peter, Gianaris, Thomas J., Giannotta, Steven L., Giglio, Pierre, Gilad, Ronit, Gill, Brian J.A., Gillick, John L., Gilmer, Holly S., Gjedde, Albert H., Glenn, Chad A., Godil, Saniya S., Goel, Atul, Gokaslan, Ziya L., Goldberg, Jacob L., Goldstein, Hannah E., Golub, Danielle, Gonzalez, Glenn A., Gonzalez-Martinez, Jorge Á., Goodden, John R., Goodman, J. Clay, Goodrich, James Tait, Goodwin, C. Rory, Gordon, David S., Gottfried, Oren N., Goumnerova, Liliana C., Goyal, Anshit, Grady, M. Sean, Graffeo, Christopher S., Grafman, Jordan H., Gragnaniello, Cristian, Grande, Andrew W., Grant, Gerald A., Grebenciucova, Elena, Greenfield, Jeffrey, Grimaudo, Heather C., Groff, Michael W., Gross, Robert E., Grossman, Rachel, Groves, Mari L., Gstoettner, Clemens, Guenette, Jeffrey P., Günel, Murat, Gupta, Nalin, Gutman, Matthew J., Guyer, Richard D., Hachem, Laureen D., Haddad, Georges F., Hadjipanayis, Constantinos G., Hafez, Daniel M., Hagan, John P., Haglund, Michael M., Haines, Stephen J., Haldeman, Clayton L., Halvorson, Kyle G., Hamberger, Marla J., Hamdi, Hussein, Hamilton, D. Kojo, Hamilton, Kimberly M., Hamilton, Mark G., Hankinson, Todd C., Haq, Ihtsham ul, Harbaugh, Robert E., Hardesty, Douglas A., Hardigan, Trevor, Hariz, Marwan, Harrigan, Mark R., Harrop, James S., Hartings, Jed A., Härtl, Roger, Harward, Stephen C., II, Hasbun, Rodrigo, Hawryluk, Gregory W.J., Hayman, Erik, Hayward, Richard D., He, Lucy, Healy, Andrew T., Heary, Robert F., Heiden, Petra, Heinricher, Mary M., Heller, Robert S., Retel Helmrich, Isabel R.A., Helmy, Adel, Heman-Ackah, Sabrina M., Hendricks, Benjamin K., Herendeen, John S., Heros, Roberto C., Herrup, Karl, Hervey-Jumper, Shawn L., Heuer, Gregory G., Heyer, Eric J., Higuchi, Yoshinori, Hillary, Frank G., Ho, Winson S., Hoang, Nguyen, Hoang, Stanley, Hoelscher, Christian, Hoffer, S. Alan, Hofstetter, Christoph, Holland, Eric C., Holland, Ryan M., Holste, Katherine, Hongo, Kazuhiro, Horisawa, Shiro, Horner, Philip J., Howard, Matthew A., III, Hsueh, Brian, Huang, Judy, Huang, Kevin T., Huang, Michael C., Huang, Raymond Y., Hudgins, Eric, Huguenard, Anna, Hunt, Matthew A., Hurlbert, R. John, Hussein, Ahmed E., Hutchinson, Peter J., Huttner, Anita, Huys, Daniel, Hwang, Steven W., Iaccarino, Mary A., Ibrahim, Mohab, Iliff, Jeffrey J., Ilyas, Adeel, Ingram, Susan L., Isaacs, Albert M., Isaias, Ioannis U., Iskandar, Bermans J., Iyer, Aditya K., Jabbour, Pascal, Jackson, Christopher M., Jadhav, Ashutosh P., Jakobs, Martin, Jallo, George I., Jane, John A., Jr., Janigro, Damir, Jankowitz, Brian T., Jea, Andrew, Jehi, Lara, Jellinger, Kurt A., Jenson, Amanda V., Jho, Diana, Jiang, Bowen, Jiang, Fan, Jimenez, David F., Jimenez, Lincoln, Jin, Haiyan, Jo, Jasmin T., Johanson, Conrad E., Johnson, Luke A., Johnson, Mark D., Johnson, Nathaniel, Jones, Adrian C., Jones, Kristen E., Jones, Tuckerman, Joseph, Jacob R., Joshi, Krishna C., Joshi, Rushikesh S., Jovin, Tudor G., Julian, Alex, Juraschka, Kyle, Abdo do Seixo Kadri, Paulo, Kalani, M. Yashar S., Kalanithi, Paul S.A., Kalfas, Iain H., Kalnins, Aleksandrs Uldis, Kamath, Ashwin A., Kanev, Paul M., Kang, Daniel G., Kang, James D., Kanter, Adam S., Kaplitt, Michael G., Kappel, Ari D., Karikari, Isaac, Karsy, Michael, Kasliwal, Manish K., Kaufmann, Anthony M., Kawasaki, Hiroto, Kellner, Christopher P., Kelly, Alexander P., Kemeny, Andras A., Kestle, John R.W., Khalsa, Siri S., Khan, Imad S., Khan, Nadia, Khan, Tariq, Khanna, Omaditya, Khanna, Ryan, Kigerl, Kristina A., Kim, Dong H., Kim, Louis J., Kim, Paul K., Kim, Thomas A., Kim, Won, Kirnaz, Sertaç, Kirsch, Wolff, Kitchen, Neil D., Klein, Joshua P., Kliot, Michel, Knightly, John J., Knisely, Jonathan, Knopman, Jared, Ko, Andrew L., Kobayashi, Katsuya, Kobets, Andrew J., Koch, Matthew J., Kocharian, Gary, Koerner, John D., Kohara, Kotaro, Kohn, Max, Kolias, Angelos G., Koo, Clara S., Kosztowski, Thomas, Kotecha, Rupesh R., Kovach, Christopher K., Kraemer, Mark R., Krauss, Joachim K., Krieg, Sandro M., Krieger, Mark D., Krishnaney, Ajit A., Ksendzovsky, Alexander, Kulkarni, Abhaya V., Vijay Kumar, Gomatam R., Kumar, Sachin A., Kung, David K., Kuo, Jeffrey V., Kvint, Svetlana, Kwan, Kenny, Issa Laack, Nadia N., Ladner, Travis R., Lafage, Renaud, Lafage, Virginie, Lam, Arthur M., Lamm, Adam G., Landazuri, Patrick, Lanzino, Giuseppe, Larson, Paul, Lau, Catherine Y., Lau, Darryl, Lavine, Sean D., Lawler, Sean E., Laws, Edward R., Jr., Lawton, Michael T., Laxpati, Nealen G., Lebed, Brett D., Lee, Cheng-Chia, Lee, Jonathan J., Lee, Ryan P., Lee, Sangmi, Lehman, Ronald A., Jr., Lenke, Lawrence G., Le Roux, Peter D., Leuthardt, Eric C., Levin, Emily, Levy, Elad I., Lewis, Evan M., Lhatoo, Samden, Li, Dianyou, Li, Yingda, Ching Ng, Angela Li, Liau, Linda M., Liebenow, Brittany, Lieberman, Isador H., Limbrick, David D., Jr., Lin, Emily, Lin, Kant Y., Lin, Zhengyu, Lingsma, Hester F., Linskey, Mark E., Lipsman, Nir, Litvack, Zachary N., Liu, James K.C., Liu, Kenneth C., Liu, Wei, Lober, Robert M., Lohkamp, Laura-Nanna, Lonser, Russell R., Louvi, Angeliki, Lozano, Andres M., Lu, Victor M., Luciano, Mark G., Lukas, Rimas V., Luo, Lan, Ma, Lijun, Maas, Andrew I.R., Macdonald, R. Loch, Mack, William J., Mackey, Kimberly A., Macki, Mohamed, MacLachlan, Lara S., Madarash, Holly Oemke, Madsen, Peter J., Maegele, Marc, Magistretti, Pierre J., Mahan, Mark A., Maher, Cormac O., Mahtabfar, Aria, Majeed, Kashif, Makarenko, Serge, Makley, Amy T., Malessy, Martijn J.A., Malik, Athar N., Mallucci, Conor, Mambelli, Dorian D., Mammi, Marco, Mangano, Francesco T., Maniker, Allen H., Manley, Geoffrey T., Manolidis, Spiros, Maroon, Joseph C., Martin, Alastair, Martin, Neil A., Martirosian, Vahan, Martirosyan, Nikolay L., Maslink, Colin, Massie, Lara, Mathur, Amit M., Matias, Caio M., Mauer, Kimberly M., Maulucci, Christopher M., Maurer, Robert K., Mazur, Marcus D., Mazwi, Nicole, McAllister, James P., II, McClain, Craig D., McCormack, Ryan M., McCrea, Michael A., McCutcheon, Ian E., McDermott, Michael W., McDougall, Cameron G., McDougall, Cameron M., McEvoy, Andrew W., McGrath, Hari, McGrath, Lynn, Jr., McKhann, Guy M., McMahon, J. Tanner, McPheeters, Matthew J., Meaney, David F., Medel, Ricky, Medress, Zachary, Mehta, Minesh P., Menacho, Sarah T., Menezes, Arnold H., Menon, David K., Mergeche, Joanna L., Meyer, Fredric B., Meyer, Jenna, Meyer, Scott A., Meyers, Philip M., Midha, Rajiv, Miller, Charles A., Miller, Jonathan P., Miller, Neil R., Mirza, Farhan A., Mirzadeh, Zaman, Miserocchi, Anna, Misra, Basant K., Missios, Symeon, Miyagishima, Danielle F., Miyashiro, Kevin Y., Mizuno, Junichi, Mizuno, Shuichi, Mocco, J., Mohyeldin, Ahmed, Mokin, Maxim, Molinaro, Annette M., Moliterno, Jennifer, Monteith, Stephen J., Montenegro, Thiago S., Mooney, Michael A., Moosa, Shayan, Morales, Diego M., Morgan, Clinton D., Morgan, Isabella, Morgan, Michael Kerin, Mortimer, Vance R., Moss, Nelson, Moss, S. 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Richard, Wintermark, Max, Wipplinger, Christoph, Witiw, Christopher D., Wolfla, Christopher E., Wolinsky, Jean-Paul, Wong, Eric T., Worrell, Gregory A., Wrensch, Margaret R., Wright, Christina H., Wu, Jau-Ching, Wu, Jenny, Wu, Kyle C., Wu, Pang Hung, Xu, David S., Xu, Linda Wei, Xu, Yifan, Xu, Zhen, Xu, Zhiyuan, Yaeger, Kurt A., Yahanda, Alexander T., Yan, Rachel E., Yan, Yuanqing, Yang, George L., Yasuno, Katsuhito, Yen, Chun-Po, Yokota, Kazuya, Yolcu, Yagiz Ugur, Young, Timothy P., Yu, Jennifer S., Yue, John K., Yuh, Esther L., Zabramski, Joseph M., Zacest, Andrew, Zacko, J. Christopher, Zada, Gabriel, Zafonte, Ross D., Zager, Eric L., Zakare-Fagbamila, Rasheedat T., Zakeri, Amanda, Zanotti, Bruno, Zawar, Ifrah, Zeineddine, Hussein A., Zellner, Elizabeth G., Zhan, Shikun, Zhang, Chencheng, Zhang, Michael, Zhang, Yingying, Zibly, Zion, Zigler, Jack E., Zipfel, Gregory J., Zipser, Carl Moritz, Zrinzo, Ludvic, and Zumofen, Daniel W.

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2023
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