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2. The MHC class I MICA gene is a histocompatibility antigen in kidney transplantation

Author

Carapito, Raphael, Aouadi, Ismail, Verniquet, Martin, Untrau, Meiggie, Pichot, Angélique, Beaudrey, Thomas, Bassand, Xavier, Meyer, Sébastien, Faucher, Loic, Posson, Juliane, Morlon, Aurore, Kotova, Irina, Delbos, Florent, Walencik, Alexandre, Aarnink, Alice, Kennel, Anne, Suberbielle, Caroline, Taupin, Jean-Luc, Matern, Benedict M., Spierings, Eric, Congy-Jolivet, Nicolas, Essaydi, Arnaud, Perrin, Peggy, Blancher, Antoine, Charron, Dominique, Cereb, Nezih, Maumy-Bertrand, Myriam, Bertrand, Frédéric, Garrigue, Valérie, Pernin, Vincent, Weekers, Laurent, Naesens, Maarten, Kamar, Nassim, Legendre, Christophe, Glotz, Denis, Caillard, Sophie, Ladrière, Marc, Giral, Magali, Anglicheau, Dany, Süsal, Caner, and Bahram, Seiamak

Published
2022
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4. Matching for the nonconventional MHC-I MICA gene significantly reduces the incidence of acute and chronic GVHD

Author

Carapito, Raphael, Jung, Nicolas, Kwemou, Marius, Untrau, Meiggie, Michel, Sandra, Pichot, Angélique, Giacometti, Gaëlle, Macquin, Cécile, Ilias, Wassila, Morlon, Aurore, Kotova, Irina, Apostolova, Petya, Schmitt-Graeff, Annette, Cesbron, Anne, Gagne, Katia, Oudshoorn, Machteld, van der Holt, Bronno, Labalette, Myriam, Spierings, Eric, Picard, Christophe, Loiseau, Pascale, Tamouza, Ryad, Toubert, Antoine, Parissiadis, Anne, Dubois, Valérie, Lafarge, Xavier, Maumy-Bertrand, Myriam, Bertrand, Frédéric, Vago, Luca, Ciceri, Fabio, Paillard, Catherine, Querol, Sergi, Sierra, Jorge, Fleischhauer, Katharina, Nagler, Arnon, Labopin, Myriam, Inoko, Hidetoshi, von dem Borne, Peter A., Kuball, Jürgen, Ota, Masao, Katsuyama, Yoshihiko, Michallet, Mauricette, Lioure, Bruno, Peffault de Latour, Régis, Blaise, Didier, Cornelissen, Jan J., Yakoub-Agha, Ibrahim, Claas, Frans, Moreau, Philippe, Milpied, Noël, Charron, Dominique, Mohty, Mohamad, Zeiser, Robert, Socié, Gérard, and Bahram, Seiamak

Published
2016
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5. The MHC class I MICA gene is a histocompatibility antigen in kidney transplantation

Author

Süsal, Caner, Carapito, Raphael; Aouadi, Ismail; Verniquet, Martin; Untrau, Meiggie; Pichot, Angelique; Beaudrey, Thomas; Bassand, Xavier; Meyer, Sebastien; Faucher, Loic; Posson, Juliane; Morlon, Aurore; Kotova, Irina; Delbos, Florent; Walencik, Alexandre; Aarnink, Alice; Kennel, Anne; Suberbielle, Caroline; Taupin, Jean-Luc; Matern, Benedict M.; Spierings, Eric; Congy-Jolivet, Nicolas; Essaydi, Arnaud; Perrin, Peggy; Blancher, Antoine; Charron, Dominique; Cereb, Nezih; Maumy-Bertrand, Myriam; Bertrand, Frederic; Garrigue, Valerie; Pernin, Vincent; Weekers, Laurent; Naesens, Maarten; Kamar, Nassim; Legendre, Christophe; Glotz, Denis; Caillard, Sophie; Ladriere, Marc; Giral, Magali; Anglicheau, Dany; Bahram, Seiamak, School of Medicine, Süsal, Caner, Carapito, Raphael; Aouadi, Ismail; Verniquet, Martin; Untrau, Meiggie; Pichot, Angelique; Beaudrey, Thomas; Bassand, Xavier; Meyer, Sebastien; Faucher, Loic; Posson, Juliane; Morlon, Aurore; Kotova, Irina; Delbos, Florent; Walencik, Alexandre; Aarnink, Alice; Kennel, Anne; Suberbielle, Caroline; Taupin, Jean-Luc; Matern, Benedict M.; Spierings, Eric; Congy-Jolivet, Nicolas; Essaydi, Arnaud; Perrin, Peggy; Blancher, Antoine; Charron, Dominique; Cereb, Nezih; Maumy-Bertrand, Myriam; Bertrand, Frederic; Garrigue, Valerie; Pernin, Vincent; Weekers, Laurent; Naesens, Maarten; Kamar, Nassim; Legendre, Christophe; Glotz, Denis; Caillard, Sophie; Ladriere, Marc; Giral, Magali; Anglicheau, Dany; Bahram, Seiamak, and School of Medicine

Abstract

The identity of histocompatibility loci, besides human leukocyte antigen (HLA), remains elusive. The major histocompatibility complex (MHC) class I MICA gene is a candidate histocompatibility locus. Here, we investigate its role in a French multicenter cohort of 1,356 kidney transplants. MICA mismatches were associated with decreased graft survival (hazard ratio (HR), 2.12; 95% confidence interval (CI): 1.45-3.11; P < 0.001). Both before and after transplantation anti-MICA donor-specific antibodies (DSA) were strongly associated with increased antibody-mediated rejection (ABMR) (HR, 3.79; 95% CI: 1.94-7.39; P < 0.001; HR, 9.92; 95% CI: 7.43-13.20; P < 0.001, respectively). This effect was synergetic with that of anti-HLA DSA before and after transplantation (HR, 25.68; 95% CI: 3.31-199.41; P = 0.002; HR, 82.67; 95% CI: 33.67-202.97; P < 0.001, respectively). De novo-developed anti-MICA DSA were the most harmful because they were also associated with reduced graft survival (HR, 1.29; 95% CI: 1.05-1.58; P = 0.014). Finally, the damaging effect of anti-MICA DSA on graft survival was confirmed in an independent cohort of 168 patients with ABMR (HR, 1.71; 95% CI: 1.02-2.86; P = 0.041). In conclusion, assessment of MICA matching and immunization for the identification of patients at high risk for transplant rejection and loss is warranted., ‘Laboratoire d’Excellence’ (LabEx) TRANSPLANTEX; IdEx Unistra; SFRI-STRAT’US; INSERM; European Union (EU); European Regional Development Fund; INTERREG V Program; France’s National Research Agency (Agence Nationale de Recherche; ANR); Investment for the Future Program (Programme des Investissements d’Avenir; PIA); Strasbourg’s Interdisciplinary Thematic Institute (ITI) for Precision Medicine; TRANSPLANTEX NG; ITI 2021–2028 Program of the University of Strasbourg; CNRS; Institut Universitaire de France (IUF); Fédération Hospitalo-Universitaire (FHU) OMICARE; MSD Avenir ‘Autogen’

Published
2022

6. The MHC class I MICA gene is a histocompatibility antigen in kidney transplantation

Author

CDL HLA, CTI Spierings, Infection & Immunity, Cancer, Carapito, Raphael, Aouadi, Ismail, Verniquet, Martin, Untrau, Meiggie, Pichot, Angélique, Beaudrey, Thomas, Bassand, Xavier, Meyer, Sébastien, Faucher, Loic, Posson, Juliane, Morlon, Aurore, Kotova, Irina, Delbos, Florent, Walencik, Alexandre, Aarnink, Alice, Kennel, Anne, Suberbielle, Caroline, Taupin, Jean-Luc, Matern, Benedict M, Spierings, Eric, Congy-Jolivet, Nicolas, Essaydi, Arnaud, Perrin, Peggy, Blancher, Antoine, Charron, Dominique, Cereb, Nezih, Maumy-Bertrand, Myriam, Bertrand, Frédéric, Garrigue, Valérie, Pernin, Vincent, Weekers, Laurent, Naesens, Maarten, Kamar, Nassim, Legendre, Christophe, Glotz, Denis, Caillard, Sophie, Ladrière, Marc, Giral, Magali, Anglicheau, Dany, Süsal, Caner, Bahram, Seiamak, CDL HLA, CTI Spierings, Infection & Immunity, Cancer, Carapito, Raphael, Aouadi, Ismail, Verniquet, Martin, Untrau, Meiggie, Pichot, Angélique, Beaudrey, Thomas, Bassand, Xavier, Meyer, Sébastien, Faucher, Loic, Posson, Juliane, Morlon, Aurore, Kotova, Irina, Delbos, Florent, Walencik, Alexandre, Aarnink, Alice, Kennel, Anne, Suberbielle, Caroline, Taupin, Jean-Luc, Matern, Benedict M, Spierings, Eric, Congy-Jolivet, Nicolas, Essaydi, Arnaud, Perrin, Peggy, Blancher, Antoine, Charron, Dominique, Cereb, Nezih, Maumy-Bertrand, Myriam, Bertrand, Frédéric, Garrigue, Valérie, Pernin, Vincent, Weekers, Laurent, Naesens, Maarten, Kamar, Nassim, Legendre, Christophe, Glotz, Denis, Caillard, Sophie, Ladrière, Marc, Giral, Magali, Anglicheau, Dany, Süsal, Caner, and Bahram, Seiamak

Published
2022

8. An unusually high substitution rate in transplant-associated BK polyomavirus in vivo is further concentrated in HLA-C-bound viral peptides

Author

Domingo-Calap, Pilar, Schubert, Benjamin, Joly, Mélanie, Solis, Morgane, Untrau, Meiggie, Carapito, Raphael, Georgel, Philippe, Caillard, Sophie, Fafi-Kremer, Samira, Paul, Nicodème, Kohlbacher, Oliver, González-Candelas, Fernando, Bahram, Seiamak, Agencia Estatal de Investigación (España), Agence Nationale de la Recherche (France), Institut National de la Santé et de la Recherche Médicale (France), Institut Universitaire de France, Université de Strasbourg, Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Generalitat Valenciana, Domingo-Calap, Pilar [0000-0003-2829-8809], Schubert, Benjamin [0000-0003-3412-1102], Joly, Mélanie [0000-0003-0316-5065], Untrau, Meiggie [0000-0002-0054-8741], Georgel, Philippe [0000-0001-6853-7080], Paul, Nicodème [0000-0003-4680-3012], Kohlbacher, Oliver [0000-0003-1739-4598], González-Candelas, Fernando [0000-0002-0879-5798], Bahram, Seiamak [0000-0002-6928-9952], Domingo-Calap, Pilar, Schubert, Benjamin, Joly, Mélanie, Untrau, Meiggie, Georgel, Philippe, Paul, Nicodème, Kohlbacher, Oliver, González-Candelas, Fernando, and Bahram, Seiamak

Subjects
RNA viruses, 0301 basic medicine, Mutation rate, Physiology, viruses, Urine, Pathology and Laboratory Medicine, medicine.disease_cause, Biochemistry, Medicine and Health Sciences, Biology (General), Amino Acids, Genome Evolution, Phylogeny, Data Management, Mutation, Organic Compounds, High-Throughput Nucleotide Sequencing, Phylogenetic Analysis, DNA virus, Genomics, Body Fluids, BK virus, Phylogenetics, Chemistry, Medical Microbiology, Viral Pathogens, Viral evolution, Viruses, Physical Sciences, Evolutionary Rate, Pathogens, Anatomy, Research Article, Computer and Information Sciences, Evolutionary Processes, QH301-705.5, Immunology, Genome, Viral, HLA-C Antigens, Biology, Microbiology, Molecular Evolution, Viral Evolution, Virus, Deep sequencing, 03 medical and health sciences, Virology, Genetics, medicine, Humans, Evolutionary Systematics, Microbial Pathogens, Molecular Biology, Taxonomy, Evolutionary Biology, Polyomavirus Infections, Organic Chemistry, Organisms, Chemical Compounds, Biology and Life Sciences, Computational Biology, Proteins, Organ Transplantation, RC581-607, 030112 virology, Organismal Evolution, Peptide Fragments, Polyomaviruses, 030104 developmental biology, Amino Acid Substitution, BK Virus, Microbial Evolution, Parasitology, Immunologic diseases. Allergy, DNA viruses
Abstract

Infection with human BK polyomavirus, a small double-stranded DNA virus, potentially results in severe complications in immunocompromised patients. Here, we describe the in vivo variability and evolution of the BK polyomavirus by deep sequencing. Our data reveal the highest genomic evolutionary rate described in double-stranded DNA viruses, i.e., 10−3–10−5 substitutions per nucleotide site per year. High mutation rates in viruses allow their escape from immune surveillance and adaptation to new hosts. By combining mutational landscapes across viral genomes with in silico prediction of viral peptides, we demonstrate the presence of significantly more coding substitutions within predicted cognate HLA-C-bound viral peptides than outside. This finding suggests a role for HLA-C in antiviral immunity, perhaps through the action of killer cell immunoglobulin-like receptors. The present study provides a comprehensive view of viral evolution and immune escape in a DNA virus., This work has been published under the framework of the Laboratoire d’Excellence (LABEX) TRANSPLANTEX [ANR-11-LABX0070_TRANSPLANTEX] and benefits from a funding from the French government, managed by the French National Research Agency (ANR) as part of the « Investments for the future » program (SB)(http://www.agence-nationale-recherche.fr/investissementsdavenir/). Additional support was received from the Strasbourg High Throughput Next Generation Sequencing facility (GENOMAX) (SB)(no URL available), the Institut National de la Sante et de la Recherche Medicale (INSERM)(SB) (www.inserm.fr), Initiative d’Excellence (IDEX) fund of the University of Strasbourg (UNISTRA)(SB) (www.unistra.fr), the Institut Universitaire de France (IUF)(SB)(http://www.iufrance.fr), projects BFU2014-58656R and BFU2017-89594R from Ministry of Economy and Competitiveness (MINECO; Spanish Government) (http://www.idi. mineco.gob.es)(FGC) and the project PROMETEO/2016/122 from the Generalitat Valenciana (FGC) (www.gva.es/).

Published
2018

9. An unusually high substitution rate in transplant-associated BK polyomavirus in vivo is further concentrated in HLA-C-bound viral peptides

Author

Agence Nationale de la Recherche (France), Agencia Estatal de Investigación (España), Institut National de la Santé et de la Recherche Médicale (France), Institut Universitaire de France, Université de Strasbourg, Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Generalitat Valenciana, Domingo-Calap, Pilar [0000-0003-2829-8809], Schubert, Benjamin [0000-0003-3412-1102], Joly, Mélanie [0000-0003-0316-5065], Untrau, Meiggie [0000-0002-0054-8741], Georgel, Philippe [0000-0001-6853-7080], Paul, Nicodème [0000-0003-4680-3012], Kohlbacher, Oliver [0000-0003-1739-4598], González-Candelas, Fernando [0000-0002-0879-5798], Bahram, Seiamak [0000-0002-6928-9952], Domingo-Calap, Pilar, Schubert, Benjamin, Joly, Mélanie, Solis, Morgane, Untrau, Meiggie, Carapito, Raphael, Georgel, Philippe, Caillard, Sophie, Fati-Kremer, Samira, Paul, Nicodème, Kohlbacher, Oliver, González-Candelas, Fernando, Bahram, Seiamak, Agence Nationale de la Recherche (France), Agencia Estatal de Investigación (España), Institut National de la Santé et de la Recherche Médicale (France), Institut Universitaire de France, Université de Strasbourg, Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Generalitat Valenciana, Domingo-Calap, Pilar [0000-0003-2829-8809], Schubert, Benjamin [0000-0003-3412-1102], Joly, Mélanie [0000-0003-0316-5065], Untrau, Meiggie [0000-0002-0054-8741], Georgel, Philippe [0000-0001-6853-7080], Paul, Nicodème [0000-0003-4680-3012], Kohlbacher, Oliver [0000-0003-1739-4598], González-Candelas, Fernando [0000-0002-0879-5798], Bahram, Seiamak [0000-0002-6928-9952], Domingo-Calap, Pilar, Schubert, Benjamin, Joly, Mélanie, Solis, Morgane, Untrau, Meiggie, Carapito, Raphael, Georgel, Philippe, Caillard, Sophie, Fati-Kremer, Samira, Paul, Nicodème, Kohlbacher, Oliver, González-Candelas, Fernando, and Bahram, Seiamak

Abstract

Infection with human BK polyomavirus, a small double-stranded DNA virus, potentially results in severe complications in immunocompromised patients. Here, we describe the in vivo variability and evolution of the BK polyomavirus by deep sequencing. Our data reveal the highest genomic evolutionary rate described in double-stranded DNA viruses, i.e., 10−3–10−5 substitutions per nucleotide site per year. High mutation rates in viruses allow their escape from immune surveillance and adaptation to new hosts. By combining mutational landscapes across viral genomes with in silico prediction of viral peptides, we demonstrate the presence of significantly more coding substitutions within predicted cognate HLA-C-bound viral peptides than outside. This finding suggests a role for HLA-C in antiviral immunity, perhaps through the action of killer cell immunoglobulin-like receptors. The present study provides a comprehensive view of viral evolution and immune escape in a DNA virus.

Published
2018

10. The MHC class I MICAgene is a histocompatibility antigen in kidney transplantation

Author

Carapito, Raphael, Aouadi, Ismail, Verniquet, Martin, Untrau, Meiggie, Pichot, Angélique, Beaudrey, Thomas, Bassand, Xavier, Meyer, Sébastien, Faucher, Loic, Posson, Juliane, Morlon, Aurore, Kotova, Irina, Delbos, Florent, Walencik, Alexandre, Aarnink, Alice, Kennel, Anne, Suberbielle, Caroline, Taupin, Jean-Luc, Matern, Benedict M., Spierings, Eric, Congy-Jolivet, Nicolas, Essaydi, Arnaud, Perrin, Peggy, Blancher, Antoine, Charron, Dominique, Cereb, Nezih, Maumy-Bertrand, Myriam, Bertrand, Frédéric, Garrigue, Valérie, Pernin, Vincent, Weekers, Laurent, Naesens, Maarten, Kamar, Nassim, Legendre, Christophe, Glotz, Denis, Caillard, Sophie, Ladrière, Marc, Giral, Magali, Anglicheau, Dany, Süsal, Caner, and Bahram, Seiamak

Abstract

The identity of histocompatibility loci, besides human leukocyte antigen (HLA), remains elusive. The major histocompatibility complex (MHC) class I MICAgene is a candidate histocompatibility locus. Here, we investigate its role in a French multicenter cohort of 1,356 kidney transplants. MICAmismatches were associated with decreased graft survival (hazard ratio (HR), 2.12; 95% confidence interval (CI): 1.45–3.11; P< 0.001). Both before and after transplantation anti-MICA donor-specific antibodies (DSA) were strongly associated with increased antibody-mediated rejection (ABMR) (HR, 3.79; 95% CI: 1.94–7.39; P< 0.001; HR, 9.92; 95% CI: 7.43–13.20; P< 0.001, respectively). This effect was synergetic with that of anti-HLA DSA before and after transplantation (HR, 25.68; 95% CI: 3.31–199.41; P= 0.002; HR, 82.67; 95% CI: 33.67–202.97; P< 0.001, respectively). De novo-developed anti-MICA DSA were the most harmful because they were also associated with reduced graft survival (HR, 1.29; 95% CI: 1.05–1.58; P= 0.014). Finally, the damaging effect of anti-MICA DSA on graft survival was confirmed in an independent cohort of 168 patients with ABMR (HR, 1.71; 95% CI: 1.02–2.86; P= 0.041). In conclusion, assessment of MICAmatching and immunization for the identification of patients at high risk for transplant rejection and loss is warranted.

Published
2022
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11. An unusually high substitution rate in transplant-associated BK polyomavirus in vivo is further concentrated in HLA-C-bound viral peptides

Author

Domingo-Calap, Pilar, primary, Schubert, Benjamin, additional, Joly, Mélanie, additional, Solis, Morgane, additional, Untrau, Meiggie, additional, Carapito, Raphael, additional, Georgel, Philippe, additional, Caillard, Sophie, additional, Fafi-Kremer, Samira, additional, Paul, Nicodème, additional, Kohlbacher, Oliver, additional, González-Candelas, Fernando, additional, and Bahram, Seiamak, additional

Published
2018
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12. Thyroid hormone perturbation in a minipig model

Author

Singh, Pramila, primary, Nielsen, Jonas Boje, additional, Decorde, Joachim, additional, Erratico, Claudio-Alberto, additional, Fonsi, Massimiliano, additional, Richert, Lysiane, additional, Parmentier, Céline, additional, Untrau, Meiggie, additional, Forster, Roy, additional, Bentz, Sandrine, additional, and Spézia, François, additional

Published
2018
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14. A new MHC-linked susceptibility locus for primary Sjögren’s syndrome: MICA

Author

Carapito, Raphael, primary, Gottenberg, Jacques-Eric, additional, Kotova, Irina, additional, Untrau, Meiggie, additional, Michel, Sandra, additional, Naegely, Lydie, additional, Aouadi, Ismail, additional, Kwemou, Marius, additional, Paul, Nicodème, additional, Pichot, Angélique, additional, Locke, James, additional, Bowman, Simon J., additional, Griffiths, Bridget, additional, Sivils, Kathy L., additional, Sibilia, Jean, additional, Inoko, Hidetoshi, additional, Micelli-Richard, Corinne, additional, Nocturne, Gaétane, additional, Ota, Masao, additional, Ng, Wan-Fai, additional, Mariette, Xavier, additional, and Bahram, Seiamak, additional

Published
2017
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15. Matching for the non-conventional MHC-I MICA gene significantly reduces the incidence of acute and chronic GVHD

Author

Carapito, Raphael, Jung, Nicolas, Kwemou, Marius, Untrau, Meiggie, Michel, Sandra, Pichot, Angélique, Giacometti, Gaëlle, Macquin, Cécile, Ilias, Wassila, Morlon, Aurore, Kotova, Irina, Apostolova, Petya, Schmitt-Graeff, Annette, Cesbron, Anne, Gagne, Katia, Oudshoorn, Machteld, van der Holt, Bronno, Labalette, Myriam, Spierings, Eric, Picard, Christophe, Loiseau, Pascale, Tamouza, Ryad, Toubert, Antoine, Parissiadis, Anne, Dubois, Valérie, Lafarge, Xavier, Maumy-Bertrand, Myriam, Bertrand, Frédéric, Vago, Luca, Ciceri, Fabio, Paillard, Catherine, Querol, Sergi, Sierra, Jorge, Fleischhauer, Katharina, Nagler, Arnon, Labopin, Myriam, Inoko, Hidetoshi, von dem Borne, Peter A, Kuball, Jürgen H E, Ota, Masao, Katsuyama, Yoshihiko, Michallet, Mauricette, Lioure, Bruno, Peffault de Latour, Régis, Blaise, Didier, Cornelissen, Jan J, Yakoub-Agha, Ibrahim, Claas, Frans, Moreau, Philippe, Milpied, Noël, Charron, Dominique, Mohty, Mohamad, Zeiser, Robert, Socié, Gérard, Bahram, Seiamak, Carapito, Raphael, Jung, Nicolas, Kwemou, Marius, Untrau, Meiggie, Michel, Sandra, Pichot, Angélique, Giacometti, Gaëlle, Macquin, Cécile, Ilias, Wassila, Morlon, Aurore, Kotova, Irina, Apostolova, Petya, Schmitt-Graeff, Annette, Cesbron, Anne, Gagne, Katia, Oudshoorn, Machteld, van der Holt, Bronno, Labalette, Myriam, Spierings, Eric, Picard, Christophe, Loiseau, Pascale, Tamouza, Ryad, Toubert, Antoine, Parissiadis, Anne, Dubois, Valérie, Lafarge, Xavier, Maumy-Bertrand, Myriam, Bertrand, Frédéric, Vago, Luca, Ciceri, Fabio, Paillard, Catherine, Querol, Sergi, Sierra, Jorge, Fleischhauer, Katharina, Nagler, Arnon, Labopin, Myriam, Inoko, Hidetoshi, von dem Borne, Peter A, Kuball, Jürgen H E, Ota, Masao, Katsuyama, Yoshihiko, Michallet, Mauricette, Lioure, Bruno, Peffault de Latour, Régis, Blaise, Didier, Cornelissen, Jan J, Yakoub-Agha, Ibrahim, Claas, Frans, Moreau, Philippe, Milpied, Noël, Charron, Dominique, Mohty, Mohamad, Zeiser, Robert, Socié, Gérard, and Bahram, Seiamak

Published
2016

16. Matching for the non-conventional MHC-I MICA gene significantly reduces the incidence of acute and chronic GVHD

Author

CDL Celdiagnostiek, Infection & Immunity, MS Hematologie, Regenerative Medicine and Stem Cells, Cancer, Carapito, Raphael, Jung, Nicolas, Kwemou, Marius, Untrau, Meiggie, Michel, Sandra, Pichot, Angélique, Giacometti, Gaëlle, Macquin, Cécile, Ilias, Wassila, Morlon, Aurore, Kotova, Irina, Apostolova, Petya, Schmitt-Graeff, Annette, Cesbron, Anne, Gagne, Katia, Oudshoorn, Machteld, van der Holt, Bronno, Labalette, Myriam, Spierings, Eric, Picard, Christophe, Loiseau, Pascale, Tamouza, Ryad, Toubert, Antoine, Parissiadis, Anne, Dubois, Valérie, Lafarge, Xavier, Maumy-Bertrand, Myriam, Bertrand, Frédéric, Vago, Luca, Ciceri, Fabio, Paillard, Catherine, Querol, Sergi, Sierra, Jorge, Fleischhauer, Katharina, Nagler, Arnon, Labopin, Myriam, Inoko, Hidetoshi, von dem Borne, Peter A, Kuball, Jürgen H E, Ota, Masao, Katsuyama, Yoshihiko, Michallet, Mauricette, Lioure, Bruno, Peffault de Latour, Régis, Blaise, Didier, Cornelissen, Jan J, Yakoub-Agha, Ibrahim, Claas, Frans, Moreau, Philippe, Milpied, Noël, Charron, Dominique, Mohty, Mohamad, Zeiser, Robert, Socié, Gérard, Bahram, Seiamak, CDL Celdiagnostiek, Infection & Immunity, MS Hematologie, Regenerative Medicine and Stem Cells, Cancer, Carapito, Raphael, Jung, Nicolas, Kwemou, Marius, Untrau, Meiggie, Michel, Sandra, Pichot, Angélique, Giacometti, Gaëlle, Macquin, Cécile, Ilias, Wassila, Morlon, Aurore, Kotova, Irina, Apostolova, Petya, Schmitt-Graeff, Annette, Cesbron, Anne, Gagne, Katia, Oudshoorn, Machteld, van der Holt, Bronno, Labalette, Myriam, Spierings, Eric, Picard, Christophe, Loiseau, Pascale, Tamouza, Ryad, Toubert, Antoine, Parissiadis, Anne, Dubois, Valérie, Lafarge, Xavier, Maumy-Bertrand, Myriam, Bertrand, Frédéric, Vago, Luca, Ciceri, Fabio, Paillard, Catherine, Querol, Sergi, Sierra, Jorge, Fleischhauer, Katharina, Nagler, Arnon, Labopin, Myriam, Inoko, Hidetoshi, von dem Borne, Peter A, Kuball, Jürgen H E, Ota, Masao, Katsuyama, Yoshihiko, Michallet, Mauricette, Lioure, Bruno, Peffault de Latour, Régis, Blaise, Didier, Cornelissen, Jan J, Yakoub-Agha, Ibrahim, Claas, Frans, Moreau, Philippe, Milpied, Noël, Charron, Dominique, Mohty, Mohamad, Zeiser, Robert, Socié, Gérard, and Bahram, Seiamak

Published
2016

17. A de novo ADCY5 mutation causes early‐onset autosomal dominant chorea and dystonia

Author

Carapito, Raphael, primary, Paul, Nicodème, additional, Untrau, Meiggie, additional, Le Gentil, Marion, additional, Ott, Louise, additional, Alsaleh, Ghada, additional, Jochem, Pierre, additional, Radosavljevic, Mirjana, additional, Le Caignec, Cédric, additional, David, Albert, additional, Damier, Philippe, additional, Isidor, Bertrand, additional, and Bahram, Seiamak, additional

Published
2014
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18. Matching of MHC Class I Chain-Related Genes a and B Is Associated with Reduced Incidence of Severe Acute Graft-Versus-Host Disease after Unrelated Hematopoietic Stem Cell Transplantation

Author

Carapito, Raphael, primary, Jung, Nicolas, additional, Untrau, Meiggie, additional, Michel, Sandra, additional, Pichot, Angélique, additional, Giacometti, Gaëlle, additional, Cesbron, Anne, additional, Gagne, Katia, additional, Oudshoorn, Machteld, additional, van Der Holt, Ronnie, additional, Labalette, Myriam, additional, Spierings, Eric, additional, Picard, Christophe, additional, Loiseau, Pascale, additional, Tamouza, Ryad, additional, Toubert, Antoine, additional, Hanau, Daniel, additional, Parissiadis, Anne, additional, Dubois, Valerie, additional, Raus, Nicole, additional, Lafarge, Xavier, additional, Vago, Luca, additional, Ciceri, Fabio, additional, Paillard, Catherine, additional, Querol, Sergio, additional, Sierra, Jordi, additional, Fleischhauer, Katharina, additional, Nagler, Arnon, additional, Hoffmann, Miriam, additional, Milpied, Noël, additional, Michallet, Mauricette, additional, Lioure, Bruno, additional, Peffault de Latour, Régis, additional, Labopin, Myriam, additional, Inoko, Hidetoshi, additional, Claas, Franz, additional, Blaise, Didier, additional, Yakoub-Agha, Ibrahim, additional, Moreau, Philippe, additional, Charron, Dominique, additional, Ota, Masao, additional, Mohty, Mohamad, additional, Socié, Gérard, additional, and Bahram, Seiamak, additional

Published
2014
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19. A new mutation in the C-SH2 domain of PTPN11 causes Noonan syndrome with multiple giant cell lesions

Author

Carapito, Raphael, primary, Paul, Nicodème, additional, Untrau, Meiggie, additional, Ott, Louise, additional, Corradini, Nadège, additional, Poignant, Sylvaine, additional, Geffroy, Loïc, additional, Caldagues, Emmanuelle, additional, Heymann, Marie-Françoise, additional, Cassagnau, Elisabeth, additional, Isidor, Bertrand, additional, and Bahram, Seiamak, additional

Published
2013
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20. Matching for the nonconventional MHC-I MICAgene significantly reduces the incidence of acute and chronic GVHD

Author

Carapito, Raphael, Jung, Nicolas, Kwemou, Marius, Untrau, Meiggie, Michel, Sandra, Pichot, Angélique, Giacometti, Gaëlle, Macquin, Cécile, Ilias, Wassila, Morlon, Aurore, Kotova, Irina, Apostolova, Petya, Schmitt-Graeff, Annette, Cesbron, Anne, Gagne, Katia, Oudshoorn, Machteld, van der Holt, Bronno, Labalette, Myriam, Spierings, Eric, Picard, Christophe, Loiseau, Pascale, Tamouza, Ryad, Toubert, Antoine, Parissiadis, Anne, Dubois, Valérie, Lafarge, Xavier, Maumy-Bertrand, Myriam, Bertrand, Frédéric, Vago, Luca, Ciceri, Fabio, Paillard, Catherine, Querol, Sergi, Sierra, Jorge, Fleischhauer, Katharina, Nagler, Arnon, Labopin, Myriam, Inoko, Hidetoshi, von dem Borne, Peter A., Kuball, Jürgen, Ota, Masao, Katsuyama, Yoshihiko, Michallet, Mauricette, Lioure, Bruno, Peffault de Latour, Régis, Blaise, Didier, Cornelissen, Jan J., Yakoub-Agha, Ibrahim, Claas, Frans, Moreau, Philippe, Milpied, Noël, Charron, Dominique, Mohty, Mohamad, Zeiser, Robert, Socié, Gérard, and Bahram, Seiamak

Abstract

Graft-versus-host disease (GVHD) is among the most challenging complications in unrelated donor hematopoietic cell transplantation (HCT). The highly polymorphic MHC class I chain–related gene A, MICA, encodes a stress-induced glycoprotein expressed primarily on epithelia. MICA interacts with the invariant activating receptor NKG2D, expressed by cytotoxic lymphocytes, and is located in the MHC, next to HLA-B. Hence, MICAhas the requisite attributes of a bona fide transplantation antigen. Using high-resolution sequence-based genotyping of MICA, we retrospectively analyzed the clinical effect of MICAmismatches in a multicenter cohort of 922 unrelated donor HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB110/10 allele-matched HCT pairs. Among the 922 pairs, 113 (12.3%) were mismatched in MICA. MICAmismatches were significantly associated with an increased incidence of grade III-IV acute GVHD (hazard ratio [HR], 1.83; 95% confidence interval [CI], 1.50-2.23; P< .001), chronic GVHD (HR, 1.50; 95% CI, 1.45-1.55; P< .001), and nonelapse mortality (HR, 1.35; 95% CI, 1.24-1.46; P< .001). The increased risk for GVHD was mirrored by a lower risk for relapse (HR, 0.50; 95% CI, 0.43-0.59; P< .001), indicating a possible graft-versus-leukemia effect. In conclusion, when possible, selecting a MICA-matched donor significantly influences key clinical outcomes of HCT in which a marked reduction of GVHD is paramount. The tight linkage disequilibrium between MICAand HLA-Brenders identifying a MICA-matched donor readily feasible in clinical practice.

Published
2016
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21. A new mutation in the C-SH2 domain of PTPN11 causes Noonan syndrome with multiple giant cell lesions.

Author

Carapito, Raphael, Paul, Nicodème, Untrau, Meiggie, Ott, Louise, Corradini, Nadège, Poignant, Sylvaine, Geffroy, Loïc, Caldagues, Emmanuelle, Heymann, Marie-Françoise, Cassagnau, Elisabeth, Isidor, Bertrand, and Bahram, Seiamak

Subjects
GENETIC mutation, NOONAN syndrome, PROTEIN-tyrosine kinases, PHOSPHOPROTEIN phosphatases, GIANT cell tumors, MITOGEN-activated protein kinases, HEART diseases
Abstract

Noonan syndrome (NS), an autosomal dominant multisystem disorder, is caused by the dysregulation of the RAS-MAPK pathway and is characterized by short stature, heart defects, pectus excavatum, webbed neck, learning problems, cryptorchidism and facial dysmorphism. We here present the clinical and molecular characterization of a family with NS and multiple giant cell lesions (MGCLs). The proband is a 12-year-old girl with NS and MGCL. Her mother shows typical NS without MGCL. Whole-exome sequencing of the girl, her mother and her healthy maternal grand parents revealed a previously unobserved mutation in exon 5 of the PTPN11 gene (c.598 A>T; p.N200Y), transmitted from the mother to the proband. As no other modification in the RAS-MAPK pathway genes as related to Rasopathies was detected in the proband, this report demonstrates for the first time that a unique mutation affecting this, otherwise unaffected signaling route, can cause both NS and NS/MGCL in the same family. This observation further confirms that NS/MGCL is not a distinct entity but rather that MGCL represents a rare complication of NS. Moreover, the localization of the p.N200Y mutation suggests an alternative molecular mechanism for the excessive phosphatase activity of the PTPN11-encoded protein. [ABSTRACT FROM AUTHOR]

Published
2014
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22. The MHC class I MICA gene is a histocompatibility antigen in kidney transplantation

Author

Raphael Carapito, Ismail Aouadi, Martin Verniquet, Meiggie Untrau, Angélique Pichot, Thomas Beaudrey, Xavier Bassand, Sébastien Meyer, Loic Faucher, Juliane Posson, Aurore Morlon, Irina Kotova, Florent Delbos, Alexandre Walencik, Alice Aarnink, Anne Kennel, Caroline Suberbielle, Jean-Luc Taupin, Benedict M. Matern, Eric Spierings, Nicolas Congy-Jolivet, Arnaud Essaydi, Peggy Perrin, Antoine Blancher, Dominique Charron, Nezih Cereb, Myriam Maumy-Bertrand, Frédéric Bertrand, Valérie Garrigue, Vincent Pernin, Laurent Weekers, Maarten Naesens, Nassim Kamar, Christophe Legendre, Denis Glotz, Sophie Caillard, Marc Ladrière, Magali Giral, Dany Anglicheau, Caner Süsal, Seiamak Bahram, Süsal, Caner, Carapito, Raphael, Aouadi, Ismail, Verniquet, Martin, Untrau, Meiggie, Pichot, Angelique, Beaudrey, Thomas, Bassand, Xavier, Meyer, Sebastien, Faucher, Loic, Posson, Juliane, Morlon, Aurore, Kotova, Irina, Delbos, Florent, Walencik, Alexandre, Aarnink, Alice, Kennel, Anne, Suberbielle, Caroline, Taupin, Jean-Luc, Matern, Benedict M., Spierings, Eric, Congy-Jolivet, Nicolas, Essaydi, Arnaud, Perrin, Peggy, Blancher, Antoine, Charron, Dominique, Cereb, Nezih, Maumy-Bertrand, Myriam, Bertrand, Frederic, Garrigue, Valerie, Pernin, Vincent, Weekers, Laurent, Naesens, Maarten, Kamar, Nassim, Legendre, Christophe, Glotz, Denis, Caillard, Sophie, Ladriere, Marc, Giral, Magali, Anglicheau, Dany, Bahram, Seiamak, and School of Medicine

Subjects
Graft Rejection, Biochemistry & Molecular Biology, Science & Technology, HLA ANTIBODIES, Biochemistry and molecular biology, Cell biology, Medicine, Graft Survival, Histocompatibility Antigens Class I, Cell Biology, General Medicine, Research & Experimental Medicine, Kidney Transplantation, General Biochemistry, Genetics and Molecular Biology, Antibodies, Kidney transplantation, Alloantibody, Medicine, Research & Experimental, REJECTION, Humans, Life Sciences & Biomedicine
Abstract

The identity of histocompatibility loci, besides human leukocyte antigen (HLA), remains elusive. The major histocompatibility complex (MHC) class I MICA gene is a candidate histocompatibility locus. Here, we investigate its role in a French multicenter cohort of 1,356 kidney transplants. MICA mismatches were associated with decreased graft survival (hazard ratio (HR), 2.12; 95% confidence interval (CI): 1.45-3.11; P < 0.001). Both before and after transplantation anti-MICA donor-specific antibodies (DSA) were strongly associated with increased antibody-mediated rejection (ABMR) (HR, 3.79; 95% CI: 1.94-7.39; P < 0.001; HR, 9.92; 95% CI: 7.43-13.20; P < 0.001, respectively). This effect was synergetic with that of anti-HLA DSA before and after transplantation (HR, 25.68; 95% CI: 3.31-199.41; P = 0.002; HR, 82.67; 95% CI: 33.67-202.97; P < 0.001, respectively). De novo-developed anti-MICA DSA were the most harmful because they were also associated with reduced graft survival (HR, 1.29; 95% CI: 1.05-1.58; P = 0.014). Finally, the damaging effect of anti-MICA DSA on graft survival was confirmed in an independent cohort of 168 patients with ABMR (HR, 1.71; 95% CI: 1.02-2.86; P = 0.041). In conclusion, assessment of MICA matching and immunization for the identification of patients at high risk for transplant rejection and loss is warranted., ‘Laboratoire d’Excellence’ (LabEx) TRANSPLANTEX; IdEx Unistra; SFRI-STRAT’US; INSERM; European Union (EU); European Regional Development Fund; INTERREG V Program; France’s National Research Agency (Agence Nationale de Recherche; ANR); Investment for the Future Program (Programme des Investissements d’Avenir; PIA); Strasbourg’s Interdisciplinary Thematic Institute (ITI) for Precision Medicine; TRANSPLANTEX NG; ITI 2021–2028 Program of the University of Strasbourg; CNRS; Institut Universitaire de France (IUF); Fédération Hospitalo-Universitaire (FHU) OMICARE; MSD Avenir ‘Autogen’

Published
2021

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