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Objective: Spinal intramedullary ependymomas represent a well-defined tumor entity usually warranting surgical resection. The perioperative morbidity and mortality, together with the oncological and neurological outcome of affected patients are seldomly reported on in larger clinical series. Methods: [for full text, please go to the a.m. URL]

Objective: With the global trend of increased life expectancy because of remarkable improvements in health care quality, osteoporotic fractures and degenerative spine diseases have been gaining increasing attention. Cement-augmented pedicle screw fixation has been established as the mainstay treatment [for full text, please go to the a.m. URL]

Objective: Cavernous malformations (CMs) are low-flow vascular lesions of the brain with an incidence between 0.4 and 0.9%. Depending on their location and the extent of the hemorrhage, CMs present incidentally, with epileptic seizures or with neurological deficits. However, robust evidence on [for full text, please go to the a.m. URL]

Objective: Combinatorial targeted therapy has been suggested as a powerful approach to overcome drug resistance and also might lead to a dose reduction of the single drugs. Based on a previous drug screening in meningioma cell lines, we identified OTSSP167 (MELK inhibitor) and Panobinostat (HDAC inhibitor) [for full text, please go to the a.m. URL]

Objective: Visual field deficits (VFD) due to optic radiation (OR) injury are a common complication among patients with lesions in the temporo-occipital lobe.The advent of diffusion tensor fiber tractography (DTI-FT) has been well established for planning neurological surgeries to diminish visual field [for full text, please go to the a.m. URL]

Objective: The main drivers for persisting neurological symptoms after CNS injury are secondary pathophysiological changes, such as astrogliosis and glial scarring, inhibiting axonal regeneration and functional recovery. Thus, targeting the astroglial scar has become a promising experimental treatment [for full text, please go to the a.m. URL]

Objective: Although Sonic Hedgehog (Shh) has been extensively researched on its effects in early neurogenesis and brain development since its discovery in 1980, its recently described crucial neuroprotective effects implicate important underlying mechanisms on neuronal homeostasis and repair, especially [for full text, please go to the a.m. URL]

Objective: Traumatic brain injury (TBI) is a leading cause of death worldwide. After the primary injury, a cascade of secondary injury processes is initiated, including a complex inflammatory reaction. As a critical and vulnerable brain region, the hippocampus is commonly affected by such neuroinflammation. [for full text, please go to the a.m. URL]

Objective: Following elective craniotomy, patients are usually monitored at the ICU for 24 hours. However, studies have shown that most do not need any specific intervention. While certain risk factors for the need of intensive care intervention have been identified, we lack the tools to evaluate each [for full text, please go to the a.m. URL]

Objective: Traumatic spinal cord injury (tSCI) is a devastating event, often associated with lifelong disability. Secondary to the primary injury, a cascade of secondary injury processes including blood-spinal cord barrier (BSCB) disintegration and neuroinflammation is initiated, leading to aggravation [for full text, please go to the a.m. URL]

Objective: The aim is to present our institutional experience with resection of posterior fossa tumors in children with focus on the incidence of cerebellar mutism syndrome (CMS) postoperatively and to analyze its association with multiple risk factors, such as tumor entity, size and location, surgical [for full text, please go to the a.m. URL]

Objective: Aneurysmatic subarachnoid hemorrhage (aSAH) is frequently associated with a prolonged stay on the intensive care unit (ICU) and poor prognosis, which generates the need of early predictors of clinical course and functional outcome in order to improve treatment decisions and counselling of [for full text, please go to the a.m. URL]

Objective: Isocitrate Dehydrogenase-mutated (IDHmut) and wildtype (IDHwt) gliomas are regarded as separate tumor entities with the need for accordingly adjusted therapies. IDHmut tumors have a better prognosis than the wildtype. Nevertheless they are still not curable since there is no effective drug [for full text, please go to the a.m. URL]

Objective: Tumor-organoids (TO) are mini-tumors generated from tumor tissue preserving its genotype and phenotype by maintaining the cellular heterogeneity and important components of the tumor microenvironment. We recently developed a protocol to reliably establish TOs from meningioma (MGM) in large [for full text, please go to the a.m. URL]

Objective: Angioleiomyoma, often found in subcutaneous tissue, are known to be benign vascular smooth muscle tumors. Reports on their intracranial location are, however, very scarce. Nevertheless, there might be a need for neurosurgical resection of those rare tumors in selected cases. We, therefore, [for full text, please go to the a.m. URL]

Objective: Although spinal cord stimulation (SCS) is widely used in the treatment of refractory neuropathic pain, the underlying mechanisms of action are still not fully understood. The theory behind that mechanism is based on a simplified model, the gate control theory. It postulates that stimulation[for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Objective: Intraventricular meningiomas (IVMs) are a rare subgroup accounting for less than 5% of all intracranial meningiomas. Recent studies showed evidence that IVMs are marked by a distinct chromosomal alteration with a combined loss of chromosome 22q and 1p. Here, we aim to map epigenetic [for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Objective: Use of navigation for spinal instrumentation has gained traction in recent years but preoperative trajectory-planning is a time-consuming task. We sought to develop and validate an automated planning tool for lumbosacral pedicle screws using a convolutional neural network (CNN). Methods:[for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Objective: The management of aggressive meningiomas remains challenging due to limited treatment options beside surgical removal and radiotherapy. High recurrence rates and lack of effective chemotherapies may be reasons for unfavorable prognosis of these patients. Consequently, there is an urgent need[for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Objective: Despite the overall perception of meningioma as a benign disease, 20-35% of patients experience a clinically aggressive course with debilitating treatment and poor outcome. In contrast to the growing interest in novel therapeutic strategies, the impact on health-related quality of life[for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Objective: With roughly 200 cases published world-wide since 1930, combination tumours such as collision tumours and tumour-to-tumour metastases (TTM) pose rare constellations of neoplastic disease with their clinical relevance still being a matter of debate. Methods: Among all patients operated[for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Objective: Indication and treatment of intracerebral arterio-venous malformations (AVMs) are complex and referring to the current literature in some aspects controversial. Besides conservative observation, widely-accepted treatment options encompass microsurgical resection, embolization, a combination[for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Objective: Tumour-associated macrophages (TAMs) play an emerging role in tumour progression by creating an immunosuppressive tumour microenvironment. Therefore, we investigated TAM numbers and their activation (M1/2) in primary (p‑) and recurrent (r‑) meningiomas and evaluated their[for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Objective: Until now, the Pignatti risk score has been used to guide treatment decisions after histological diagnosis of diffuse glioma WHO grade II. However, its prognostic value was derived from a historic cohort of gliomas that has been diagnosed by morphologic rather than molecular criteria. Thus,[for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Objective: Traumatic spinal cord injury (SCI) remains a devastating event with no neuroprotective treatment currently available. Disruption of the blood-spinal cord barrier (BSCB) with subsequent edema formation and neuroinflammation contributes to the disease’s seriousness. It has been linked[for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Objective: The effects of Deep Brain Stimulation (DBS) for different psychiatric disorders have been explored in clinical trials. Implantable pulse generator (IPGs) replacements represent the most common type of scheduled follow-up surgeries as stimulation parameters are usually higher compared to movement[for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Objective: Cancer-derived organoids (CDOs) are novel, complex three-dimensional ex vivo tissue cultures that accurately reflect genotype and phenotype of the original tumor with preserved cellular heterogeneity and structural architecture. They offer a new and exciting platform for studying cancer biology[for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Objective: Intracranial meningioma WHO grade I is considered a benign disease with long-term disease control after extensive surgery. However, the psychooncological burden of these patients is still poorly defined. Here, we sought to analyse health-related quality of life (QoL) after meningioma resection.[for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Objective: Odontoid type II fractures are the most common cervical spine injuries in patients over 65 years. The decision for surgical treatment in patients over 90 years of age is still controversially discussed. The aim of this study was to assess early morbidity and mortality and long-term outcome[for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Objective: Screw accuracy in spinal instrumentation has so far mainly been evaluated from a clinical point of view according to positioning within cortical bone compartments or in relation to nervous structures. In the light of the anticipated advancements of robotic assistance devices for spinal instrumentation[for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Objective: The discovery of the Isocitrate Dehydrogenase (IDH) mutation in glioma has led to a paradigm shift on how we see glioma biology. While it is clear that IDH mutated (IDHmut) and wildtype (IDHwt) tumors have to be viewed as separate entities, the underlying biological differences are still [for full text, please go to the a.m. URL], 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Objective: Post-concussive symptoms are frequent in patients with traumatic brain injury (TBI). While various efforts have been made to develop clinical prediction models for post-concussive syndrome (PCS) in adult TBI, data on this condition in children or adolescents is scarce. We, therefore, aimed[for full text, please go to the a.m. URL], 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Objective: WHO grade I intracranial gliomas are usually referred to as benign tumors and complete surgical resection is supposed to improve outcome. Unlike other types of glioma however, WHO°I tumors often affect patients at a younger age and are preferentially located within the posterior fossa[for full text, please go to the a.m. URL], 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Objective: Clivus chordomas are a rare tumor entity considered as low-grade malignancies. Treatment of choice encompasses radical surgical resection - if possible - followed by radiotherapy. Since the huge variety of tumor extension, different surgical approaches appear rational. Within the last ten[for full text, please go to the a.m. URL], 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Objective: Endoscopic third ventriculostomy (ETV) has become the method of choice in the treatment of obstructive hydrocephalus. Age and etiology could determine success rates of ETV. The outcome is worse in children, 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie