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13. Systems Pharmacology Approach to Uncontrolled Pediatric Asthma

Author

University of Maribor, Maribor, Slovenia., University Children's Hospital, University of Regensburg, Regensburg, Germany, Universidad de La Laguna, San Cristóbal de La Laguna, Santa Cruz de Tenerife, Spain., University of the Basque Country (UPV/EHU), Hospital Universitario Donostia, San Sebastián, Spain., Instituto de Salud Carlos III, Utrecht University, Utrecht, the Netherlands., Karolinska Institutet, Stockholm, Sweden, Karolinska Institutet, and Prof. dr. A.H. Maitland-van der Zee, Professor

Published
2021

24. Deepfakes on Twitter: Which Actors Control Their Spread?

Author

Ministry of Science, Innovation and Universities of Spain, Basque Government, University of the Basque Country, Pérez Dasilva, Jesús, Meso Ayerdi, Koldobika, Mendiguren Galdospin, Terese, Ministry of Science, Innovation and Universities of Spain, Basque Government, University of the Basque Country, Pérez Dasilva, Jesús, Meso Ayerdi, Koldobika, and Mendiguren Galdospin, Terese

Abstract

The term deepfake was first used in a Reddit post in 2017 to refer to videos manipulated using artificial intelligence techniques and since then it is becoming easier to create such fake videos. A recent investigation by the cybersecurity company Deeptrace in September 2019 indicated that the number of what is known as fake videos had doubled in the last nine months and that most were pornographic videos used as revenge to harm many women. The report also highlighted the potential of this technology to be used in political campaigns such as in Gabon and Malaysia. In this sense, the phenomenon of deepfake has become a concern for governments because it poses a short-term threat not only to politics, but also for fraud or cyberbullying. The starting point of this research was Twitter’s announcement of a change in its protocols to fight fake news and deepfakes. We have used the Social Network Analysis technique, with visualization as a key component, to analyze the conversation on Twitter about the deepfake phenomenon. NodeXL was used to identify main actors and the network of connections between all these accounts. In addition, the semantic networks of the tweets were analyzed to discover hidden patterns of meaning. The results show that half of the actors who function as bridges in the interactions that shape the network are journalists and media, which is a sign of the concern that this sophisticated form of manipulation generates in this collective.

Published
2021

25. Laser transformation hardening effect on hardening zone features and surface hardness of tool steel AISI D2

Author

Lesyk, D.; Igor Sikorsky Kyiv Polytechnic Institute, Kyiv, Dzhemelinskyi, V.; Igor Sikorsky Kyiv Polytechnic Institute, Kyiv, Martinez, S.; University of the Basque Country, Bilbao, Lamikiz, А.; University of the Basque Country, Bilbao, Dаnylеikо, О.; Igor Sikorsky Kyiv Polytechnic Institute, Kyiv, Hyzhevskyi, V.; Igor Sikorsky Kyiv Polytechnic Institute, Kyiv, Lesyk, D.; Igor Sikorsky Kyiv Polytechnic Institute, Kyiv, Dzhemelinskyi, V.; Igor Sikorsky Kyiv Polytechnic Institute, Kyiv, Martinez, S.; University of the Basque Country, Bilbao, Lamikiz, А.; University of the Basque Country, Bilbao, Dаnylеikо, О.; Igor Sikorsky Kyiv Polytechnic Institute, Kyiv, and Hyzhevskyi, V.; Igor Sikorsky Kyiv Polytechnic Institute, Kyiv

Abstract

The relationship of technological input regimes of the laser transformation hardening on change the hardening depth, hardening width, and hardening angle, as well as surface hardness of the tool steel AISI D2 using multifactor experiment with elements of the analysis of variance and regression equations was determined. The laser transformation hardening process implemented by controlling the heating temperature using Nd:YAG fiber laser with scanner, pyrometer and proportional-integral-differential controller. The linear and quadratic regression models are developed, as well as response surface to determine the effect of the heating temperature and feed rate of the treated surface on the energy density of the laser beam, hardening depths, hardening width, hardening angle, and surface hardness are designed. The main effect on the energy density of the laser beam has a velocity laser treatment, on the other hand, the main effect on the geometrical parameters of the laser hardened zone and surface hardness has temperature heating are shown. The optimum magnitudes of the heating temperature (1270 °C) and feed rate of the treated surface (90 mm/min) for laser transformation hardening of the tool steel AISI D2 using fiber laser with scanner were defined., Определена взаимосвязь входных технологических режимов лазерного термоупрочнения на изменение глубины, ширины и угла упрочнения, а также твердости поверхности инструментальной стали Х12МФ, с использованием многофакторного эксперимента с элементами анализа дисперсии и уравнений регрессии. Процесс лазерного термоупрочнения реализовано путем контроля температуры нагрева с использованием волоконного Nd:YAG лазера с сканатором, пирометра и пропорционально-интегрально-дифференциального контроллера. Разработаны линейные и квадратичные регрессионные модели, а также построено поверхности отзывов для определения влияния температуры нагрева и скорости перемещения обрабатываемой поверхности на плотность энергии лазерного луча, глубину, ширину и угол упрочнения, а также твердость поверхности. Показано, что основное влияние на величину плотности энергии лазерного луча имеет скорость лазерной обработки, а на геометрические параметры зоны лазерного упрочнения и твердости поверхности – температура нагрева. Определены оптимальные значения температуры нагрева (1270 °С) и скорости перемещения обрабатываемой поверхности (90 мм/мин) для лазерного термоупрочнения стали Х12МФ при использовании волоконного лазера с сканатором., Визначено взаємозв’язок вхідних технологічних режимів лазерного термозміцнення на зміну глибини, ширини і кута зміцнення, а також твердості поверхні інструментальної сталі Х12МФ, з використанням багатофакторного експерименту із елементами аналізу дисперсії та рівнянь регресії. Процес лазерного термозміцнення реалізовано шляхом контролю температури нагрівання з використанням волоконного Nd:YAG лазера з сканатором, пірометра та пропорційно-інтегрально-диференціального контролера. Розроблено лінійні та квадратичні регресійні моделі, а також побудовано поверхні відгуків для визначення впливу температури нагрівання та швидкості переміщення оброблюваної поверхні на густину енергії лазерного променя, глибину, ширину і кут зміцнення, а також твердість поверхні. Показано, що основний вплив на величину густини енергії лазерного променя має швидкість лазерної обробки, а на геометричні параметри зони лазерного зміцнення та твердості поверхні – температура нагрівання. Визначено оптимальні значення температури нагрівання (1270 °С) та швидкості переміщення оброблюваної поверхні (90 мм/хв) для лазерного термозміцнення сталі Х12МФ при використанні волоконного лазера з сканатором.

Published
2017

26. Imigrantes cubanos nos Estados Unidos: o que determina sua distribuição de ingressos?

Author

Cobas-Valdés, Aleida, University of the Basque Country, Fernández-Sainz, Ana, University of the Basque Country UPV/EHU, and Wilkinson, Stephen

Subjects
Cuban migration, Earnings distribution, Cuban workers in U.S, Socioeconomic characteristics, Quantile Regression, Cuba, trabajadores cubanos en los Estados Unidos, Características socioeconómicas, Regresión Cuantílica, Trabajadores inmigrantes. Cuba, Migración cubana, Distribución de ingresos, Trabalhadores imigrantes. Cuba, Immigrants workers, Migração cubana, Distribuição de ingressos, trabalhadores cubanos nos Estados Unidos, Características socioeconômicas, Regressão Quantílica
Abstract

Este artículo analiza la distribución de ingresos condicionales de los inmigrantes cubanos en los Estados Unidos usando OLS y analizando una Regresión Cuantílica. Los datos usados en este estudio fueron tomados del American Community Survey (ACS) de los Estados Unidos y fueron suministrados por IPUMS (2011). Los resultados muestran que incrementos en los ingresos asociados a diferentes características socioeconómicas tales como: el sexo, estado civil, etnia, manejo del idioma inglés y educación varían entre las diferentes distribuciones de ingresos. In this paper the conditional earnings distribution of Cuban immigrants in the U.S. using OLS and Quantile Regression is analyzed. The data used in the study come from the 2011 American Community Survey (ACS) in the U.S. provided by IPUMS (2011). The results show that increments in earnings associated with different socioeconomic characteristics such as: sex, marital status, ethnicity, proficiency in English and education vary across the earnings distribution. Este artigo analisa a distribuição de ingressos condicionais dos imigrantes cubanos nos Estados Unidos usando OLS e analisando uma Regressão Quantílica. Os dados usados neste estudo foram tomados do American Community Survey (ACS) dos Estados Unidos e foram subministrados por IPUMS (2011). Os resultados mostram que incrementos nos ingressos associados a diferentes características socioeconômicas tais como: o sexo, estado civil, etnia, manejo do idioma inglês e educação variam entre as diferentes distribuições de ingressos.

Published
2016

27. Portraits of French secondary education in Manitoba

Author

Baranowski, Krystyna (Education), Edgerton, Jason (Sociology), Cenoz, Jasone (University of the Basque Country), Kouritzin, Sandra (Education), Cormier, Gail L., Baranowski, Krystyna (Education), Edgerton, Jason (Sociology), Cenoz, Jasone (University of the Basque Country), Kouritzin, Sandra (Education), and Cormier, Gail L.

Abstract

This study analyzed the linguistic landscapes (Landry & Bourhis, 1997; Shohamy & Gorter, 2008) of three secondary schools in Manitoba, Canada where French was the language of instruction. Through a translanguaging (García & Kleyn, 2016) and Bourdieusian framework, linguistic landscapes were viewed as reflective of language ideologies, attitudes, language use and linguistic identity. The purpose of this study was to describe the linguistic landscapes of a French-language, a French immersion single-track and a French immersion dual-track high school. It was also important to understand how the students from the respective schools interpreted their own and other scholastic linguistic landscapes. The data for this study was collected through two interviews with each of the 37 participants and photographs from each school’s linguistic landscape. The first interview was semi-structured and the second interview was a photo-elicitation interview wherein participants analyzed a selection of images from the schools’ linguistic landscapes. Findings pointed to the differences between the school contexts, the importance of school choice, language ideologies and attitudes, linguistic identity and linguistic landscapes in education. It was found that schools that focus on French instruction in a minority context needed to increase exposure to French to counteract the power of English as the legitimized dominant language. In doing so, they also need to increase exposure to other minority languages.

Published
2018

29. Refugees in the News. Comparing Belgian and Swedish Newspaper Coverage of the European Refugee Situation during Summer 2015.

Author

ECREA Diaspora, Migration and the Media Conference. (2-3 November 2017: University of the Basque Country, Bilbao), Joris, Willem JW, Mertens, Stefan MS, Lams, Lut LL, D'Haenens, L., De Cock, Rozane DR, Sundin, Ebba, Mistiaen, Valériane Marie, ECREA Diaspora, Migration and the Media Conference. (2-3 November 2017: University of the Basque Country, Bilbao), Joris, Willem JW, Mertens, Stefan MS, Lams, Lut LL, D'Haenens, L., De Cock, Rozane DR, Sundin, Ebba, and Mistiaen, Valériane Marie

Abstract

info:eu-repo/semantics/nonPublished

Published
2017

30. Spin density matrix elements in exclusive ω electroproduction on 1 H and 2 H targets at 27.5 GeV beam energy

Author

Airapetian, A.II. Physikalisches Institut, Justus-Liebig Universität Gießen, 35392, Gießen, Germany, Akopov, N.(Yerevan Physics Institute, 375036, Yerevan, Armenia), Akopov, Z.(DESY, 22603, Hamburg, Germany), Augustyniak, W.(National Centre for Nuclear Research, 00-689, Warsaw, Poland), Avetissian, A.(Yerevan Physics Institute, 375036, Yerevan, Armenia), Blok, H. P.(National Institute for Subatomic Physics (Nikhef), 1009 DB, Amsterdam, The Netherlands), Borissov, A.(DESY, 22603, Hamburg, Germany), Bryzgalov, V.(Institute for High Energy Physics, 142281, Protvino, Moscow Region, Russia), Capiluppi, M.(Sezione di Ferrara, Istituto Nazionale di Fisica Nucleare, 44122, Ferrara, Italy), Capitani, G. P.(Laboratori Nazionali di Frascati, Istituto Nazionale di Fisica Nucleare, 00044, Frascati, Italy), Cisbani, E.(Sezione di Roma, Gruppo Collegato Sanità, Istituto Nazionale di Fisica Nucleare, 00161, Rome, Italy), Ciullo, G.(Sezione di Ferrara, Istituto Nazionale di Fisica Nucleare, 44122, Ferrara, Italy), Contalbrigo, M.(Sezione di Ferrara, Istituto Nazionale di Fisica Nucleare, 44122, Ferrara, Italy), Dalpiaz, P. F.(Sezione di Ferrara, Istituto Nazionale di Fisica Nucleare, 44122, Ferrara, Italy), Deconinck, W.(DESY, 22603, Hamburg, Germany), De Leo, R.(Sezione di Bari, Istituto Nazionale di Fisica Nucleare, 70124, Bari, Italy), De Sanctis, E.(Laboratori Nazionali di Frascati, Istituto Nazionale di Fisica Nucleare, 00044, Frascati, Italy), Diefenthaler, M.(Physikalisches Institut, Universität Erlangen-Nürnberg, 91058, Erlangen, Germany), Di Nezza, P.(Laboratori Nazionali di Frascati, Istituto Nazionale di Fisica Nucleare, 00044, Frascati, Italy), Düren, M.(II. Physikalisches Institut, Justus-Liebig Universität Gießen, 35392, Gießen, Germany), Ehrenfried, M.(II. Physikalisches Institut, Justus-Liebig Universität Gießen, 35392, Gießen, Germany), Elbakian, G.(Yerevan Physics Institute, 375036, Yerevan, Armenia), Ellinghaus, F.(Nuclear Physics Laboratory, University of Colorado, 80309-0390, Boulder, CO, USA), Etzelmüller, E.(II. Physikalisches Institut, Justus-Liebig Universität Gießen, 35392, Gießen, Germany), Fabbri, R.(DESY, 15738, Zeuthen, Germany), Felawka, L.(TRIUMF, V6T 2A3, Vancouver, BC, Canada), Frullani, S.(Sezione di Roma, Gruppo Collegato Sanità, Istituto Nazionale di Fisica Nucleare, 00161, Rome, Italy), Gabbert, D.(DESY, 15738, Zeuthen, Germany), Gapienko, G.(Institute for High Energy Physics, 142281, Protvino, Moscow Region, Russia), Gapienko, V.(Institute for High Energy Physics, 142281, Protvino, Moscow Region, Russia), Garibaldi, F.(Sezione di Roma, Gruppo Collegato Sanità, Istituto Nazionale di Fisica Nucleare, 00161, Rome, Italy), Gavrilov, G.(DESY, 22603, Hamburg, Germany), Gharibyan, V.(Yerevan Physics Institute, 375036, Yerevan, Armenia), Hartig, M.(DESY, 22603, Hamburg, Germany), Hasch, D.(Laboratori Nazionali di Frascati, Istituto Nazionale di Fisica Nucleare, 00044, Frascati, Italy), Holler, Y.(DESY, 22603, Hamburg, Germany), Hristova, I.(DESY, 15738, Zeuthen, Germany), Ivanilov, A.(Institute for High Energy Physics, 142281, Protvino, Moscow Region, Russia), Jackson, H. E.(Physics Division, Argonne National Laboratory, 60439-4843, Argonne, IL, USA), Joosten, S.(Department of Physics and Astronomy, Ghent University, 9000, Gent, Belgium), Kaiser, R.(SUPA, School of Physics and Astronomy, University of Glasgow, G12 8QQ, Glasgow, UK), Karyan, G.(Yerevan Physics Institute, 375036, Yerevan, Armenia), Keri, T.(II. Physikalisches Institut, Justus-Liebig Universität Gießen, 35392, Gießen, Germany), Kinney, E.(Nuclear Physics Laboratory, University of Colorado, 80309-0390, Boulder, CO, USA), Kisselev, A.(B.P. Konstantinov Petersburg Nuclear Physics Institute, 188300, Gatchina, Leningrad Region, Russia), Korotkov, V.(Institute for High Energy Physics, 142281, Protvino, Moscow Region, Russia), Kozlov, V.(Lebedev Physical Institute, 117924, Moscow, Russia), Kravchenko, P.(B.P. Konstantinov Petersburg Nuclear Physics Institute, 188300, Gatchina, Leningrad Region, Russia), Krivokhijine, V. G.(Joint Institute for Nuclear Research, 141980, Dubna, Russia), Lagamba, L.(Sezione di Bari, Istituto Nazionale di Fisica Nucleare, 70124, Bari, Italy), Lapikás, L.(National Institute for Subatomic Physics (Nikhef), 1009 DB, Amsterdam, The Netherlands), Lehmann, I.(SUPA, School of Physics and Astronomy, University of Glasgow, G12 8QQ, Glasgow, UK), Lenisa, P.(Sezione di Ferrara, Istituto Nazionale di Fisica Nucleare, 44122, Ferrara, Italy), Lorenzon, W.(Randall Laboratory of Physics, University of Michigan, 48109-1040, Ann Arbor, MI, USA), Ma, B.-Q.(School of Physics, Peking University, 100871, Beijing, China), Mahon, D.(SUPA, School of Physics and Astronomy, University of Glasgow, G12 8QQ, Glasgow, UK), Manaenkov, S. I.(B.P. Konstantinov Petersburg Nuclear Physics Institute, 188300, Gatchina, Leningrad Region, Russia), Mao, Y.(School of Physics, Peking University, 100871, Beijing, China), Marianski, B.(National Centre for Nuclear Research, 00-689, Warsaw, Poland), Marukyan, H.(Yerevan Physics Institute, 375036, Yerevan, Armenia), Movsisyan, A.(Sezione di Ferrara, Istituto Nazionale di Fisica Nucleare, 44122, Ferrara, Italy), Murray, M.(SUPA, School of Physics and Astronomy, University of Glasgow, G12 8QQ, Glasgow, UK), Naryshkin, Y.(B.P. Konstantinov Petersburg Nuclear Physics Institute, 188300, Gatchina, Leningrad Region, Russia), Nass, A.(Physikalisches Institut, Universität Erlangen-Nürnberg, 91058, Erlangen, Germany), Nowak, W.-D.(DESY, 15738, Zeuthen, Germany), Pappalardo, L. L.(Sezione di Ferrara, Istituto Nazionale di Fisica Nucleare, 44122, Ferrara, Italy), Perez-Benito, R.(II. Physikalisches Institut, Justus-Liebig Universität Gießen, 35392, Gießen, Germany), Petrosyan, A.(Yerevan Physics Institute, 375036, Yerevan, Armenia), Reimer, P. E.(Physics Division, Argonne National Laboratory, 60439-4843, Argonne, IL, USA), Reolon, A. R.(Laboratori Nazionali di Frascati, Istituto Nazionale di Fisica Nucleare, 00044, Frascati, Italy), Riedl, C.(DESY, 15738, Zeuthen, Germany), Rith, K.(Physikalisches Institut, Universität Erlangen-Nürnberg, 91058, Erlangen, Germany), Rostomyan, A.(DESY, 22603, Hamburg, Germany), Ryckbosch, D.(Department of Physics and Astronomy, Ghent University, 9000, Gent, Belgium), Schäfer, A.(Institut für Theoretische Physik, Universität Regensburg, 93040, Regensburg, Germany), Schnell, G.(Department of Theoretical Physics, University of the Basque Country UPV/EHU, 48080, Bilbao, Spain), Schüler, K. P.(DESY, 22603, Hamburg, Germany), Seitz, B.(SUPA, School of Physics and Astronomy, University of Glasgow, G12 8QQ, Glasgow, UK), Shibata, T.-A.(Department of Physics, Tokyo Institute of Technology, 152, Tokyo, Japan), Stahl, M.(II. Physikalisches Institut, Justus-Liebig Universität Gießen, 35392, Gießen, Germany), Stancari, M.(Sezione di Ferrara, Istituto Nazionale di Fisica Nucleare, 44122, Ferrara, Italy), Statera, M.(Sezione di Ferrara, Istituto Nazionale di Fisica Nucleare, 44122, Ferrara, Italy), Steffens, E.(Physikalisches Institut, Universität Erlangen-Nürnberg, 91058, Erlangen, Germany), Steijger, J. J. M.(National Institute for Subatomic Physics (Nikhef), 1009 DB, Amsterdam, The Netherlands), Taroian, S.(Yerevan Physics Institute, 375036, Yerevan, Armenia), Terkulov, A.(Lebedev Physical Institute, 117924, Moscow, Russia), Truty, R.(Department of Physics, University of Illinois, 61801-3080, Urbana, IL, USA), Trzcinski, A.(National Centre for Nuclear Research, 00-689, Warsaw, Poland), Tytgat, M.(Department of Physics and Astronomy, Ghent University, 9000, Gent, Belgium), Van Haarlem, Y.(Department of Physics and Astronomy, Ghent University, 9000, Gent, Belgium), Van Hulse, C.(Department of Theoretical Physics, University of the Basque Country UPV/EHU, 48080, Bilbao, Spain), Vikhrov, V.(B.P. Konstantinov Petersburg Nuclear Physics Institute, 188300, Gatchina, Leningrad Region, Russia), Vilardi, I.(Sezione di Bari, Istituto Nazionale di Fisica Nucleare, 70124, Bari, Italy), Wang, S.(School of Physics, Peking University, 100871, Beijing, China), Yaschenko, S.(DESY, 22603, Hamburg, Germany), Yen, S.(TRIUMF, V6T 2A3, Vancouver, BC, Canada), Zeiler, D.(Physikalisches Institut, Universität Erlangen-Nürnberg, 91058, Erlangen, Germany), Zihlmann, B.(DESY, 22603, Hamburg, Germany), and Zupranski, P.(National Centre for Nuclear Research, 00-689, Warsaw, Poland)

Abstract

Exclusive electroproduction of ω mesons on unpolarized hydrogen and deuterium targets is studied in the kinematic region of Q2>1.0 GeV 2 , 3.0 GeV

Published
2014

31. Commentary on Philippics Three and Four / Comentário Sobre Filípicas Três e Quarto

Author

Lera, Jonathan Lavilla de and University of the Basque Country (UPV-EHU) & Eidos: Platonisme i Modernitat

Subjects
Letras, Estudos Clássicos
Abstract

This paper offers a commentary on Philippics Three and Four. Firstly, it gives an historical background. Secondly, it deals with the rhetorical context in which Philippics Three and Fourwere designed. Doing so, it will consider some of the keys of Cicero’s rhetorical art and mastery of the language. Finally, it analyses both texts as complex rhetorical artefacts. Keywords: Cicero. Philippics. Rhetorics. RESUMO Este artigo faz um comentário sobre Filípicas Três e Quatro. Primeiramente, ele nos dá um contexto histórico. Segundo, analisa o contexto retórico no qual Filípicas Três e Quatro foram desenhados. Sendo assim, considera alguns pontos chave na retórica artística e no domínio da linguagem de Cicero. Por último, analisam ambos os textos como artefatos de retórica complexa. Palavras-chave: Cicero. Phillippics. Retórica.

Published
2016

32. The Elaboration of Human Anatomy Terminology for the Basque Language: the Contribution of Translators, Linguists and Experts

Author

Igone Zabala; University of the Basque Country UPV/EHU, Itziar San Martin; University of the Basque Country UPV/EHU, Mikel Lersundi; University of the Basque Country UPV/EHU, Jon Jatsu Azkue; University of the Basque Country UPV/EHU, Juan Luis Mendizabal; University of the Basque Country UPV/EHU, Igone Zabala; University of the Basque Country UPV/EHU, Itziar San Martin; University of the Basque Country UPV/EHU, Mikel Lersundi; University of the Basque Country UPV/EHU, Jon Jatsu Azkue; University of the Basque Country UPV/EHU, and Juan Luis Mendizabal; University of the Basque Country UPV/EHU

Abstract

El desenvolupament de la terminologia de l'anatomia humana en llengua basca: la contribució de traductors, lingüistes i experts En aquest article comparem la traducció d'un atles d'anatomia amb la revisió que es va encarregar a experts i lingüistes. L'objectiu és avaluar la mena de contribució que poden fer traductors, lingüistes i experts en l'elaboració de la terminologia de l'anatomia humana en basc. Analitzem les oracions que mostren discordances entre la traducció i la revisió respecte de les unitats lèxiques i les regles de formació usades. Hem observat que les correccions fetes pels experts i lingüistes tendeixen a substituir préstecs i calcs de regles de formació per unitats i estructures genuïnes. Arribem a la conclusió que les polítiques de planificació lingüística que pretenen proporcionar recursos terminològics propis en detriment de solucions dependents d'altres llengües no han estat assumides pels traductors per l'opacitat semàntica de la terminologia de l'anatomia i per la morfologia transparent del basc en comparació amb la del castellà.&nbsp, In this paper we compare the translation of an atlas of anatomy with the review that was carried out by experts in human anatomy and linguists. The goal is to evaluate the type of contribution that translators, linguists and experts can make in the elaboration of the terminology of human anatomy in Basque. We analyzed the sequences that showed discordances between translation and review with respect to the lexical units and the term formation patterns used. We found that the corrections made by experts and linguists show a clear tendency to replace lexical loanwords and calqued term formation rules by genuine elements and structures. We conclude that the aims of Language planning policies of gradually providing the language with terminological resources that are less dependent on other languages have not been met by translators due to the semantic opacity of anatomical terminology and the transparent morphology of Basque compared with Spanish.

Published
2012

33. Genome-Wide Analysis of DNA Copy Number Changes in Liver Steatosis

Author

Royo, Félix, Zabala, Amaia, Paz, Nerea, Acquadro, Francesco, Echevarria, José J., Zabalza, Iñaki, Cigudosa, Juan C., Zugaza, José L., and Dentistry, University of the Basque Country, Barrio Sarriena s/n, 48940 Leioa, Spain, Achucarro Basque Center for Neuroscience, Bizkaia Science and Technology Park, Bg 205, Zamudio, Spain. IKERBASQUE, Basque Foundation for Science, Bilbao, Spain., Parada, Luis A., and Salta, 4400-Salta, Argentina.

Subjects
Array-CGH, CNV, genomic profile, liver steatosis, chromosome
Abstract

Aims: Liver steatosis is the most common benign form of non-alcoholic fatty liver disease. It might be a risk factor for hepatocellular carcinoma, either (i) by causing fibrosis, which highly predisposes to hepatoma, or (ii) by being an early precursor of carcinoma, although it is usually considered not to be pre-neoplastic. We investigated the genomic profile of liver samples from patients with fatty liver disease. Study Design & Methodology: Copy number variation was investigated by array-CGH, using the Human Genome 244K catalogue array (Agilent Technologies), and changes validated by quantitative polymerase chain reaction analysis. Results: The analysis of liver biopsies from 17 patients, 10 of whom had histological diagnosis of non-alcoholic fatty liver disease, showed differences in the type of variants in patients with steatosis compared to those without steatosis at several chromosome bands, including 3q29, 6p2, 11q11 and 22q11. Conclusion: The genomic copy number changes we have demonstrated suggest that genomic structural variations may be associated with the pathogenesis or the evolution of steatosis.

Published
2013
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34. The Transparency of Explicit Content (Invited speaker)

Author

International Workshop "Indexicality (in Language and Thought)", organised by the European Network of Philosophy of Language & Mind (University of the Basque Country (UPV-EHU), Donostia, Spain), Bochner, Gregory, International Workshop "Indexicality (in Language and Thought)", organised by the European Network of Philosophy of Language & Mind (University of the Basque Country (UPV-EHU), Donostia, Spain), and Bochner, Gregory

Abstract

info:eu-repo/semantics/nonPublished

Published
2014

35. An Expert System for Mill Cutter and Cutting Parameters Selection

Author

Rubio Rodriguez, Luis, De la Sen Parte, Manuel, and Institute of Research and Development of Processes, University of the Basque Country

Subjects
TA, TJ
Abstract

This paper discusses the selection of tools in milling processes. To carry out this research, it has been developed an expert system based on numerical methods. The expert system, chooses an appropriate tool, between a known set of candidate available cutters. The knowledge base is given by limiting the process variables. They are obtained taking into account, instabilities due to tool-work-piece interaction, which are called chatter vibration, and the power available in the spindle motor. Then, a tool cost model is designed as pattern, which is then used to decide the suitable cutting tool. Once the cutting tool is selected, the optimal cutting parameters are calculated. To obtain those parameters other two cost function are designed, which are dependent on the frequency and on time domain output signal properties. An example is presented to illustrate the method.

Published
2005

36. The stability of the roommate problem revisited

Author

University of the Basque Country - Dep. Ftos. A. Economico, Inarra, Elena, Larrea, Conchi, Molis Banales, Elena, University of the Basque Country - Dep. Ftos. A. Economico, Inarra, Elena, Larrea, Conchi, and Molis Banales, Elena

Abstract

The lack of stability in some matching problems suggests that alternative solution concepts to the core might be a step towards furthering our understanding of matching market performance. We propose absorbing sets as a solution for the class of roommate problems with strict preferences. This solution, which always exists, either gives the matchings in the core or predicts other matchings when the core is empty. Furthermore, it satisfies the interesting property of outer stability. We also determine the matchings in absorbing sets and find that in the case of multiple absorbing sets a similar structure is shared by all.

Published
2010

38. Study of Flare Assessment in Systemic Lupus Erythematosus Based on Paper Patients

Author

1 UCL, London, England Show more 2 Hosp Trop Dis, London, England Show more 3 Feinstein Inst Med Res, Manhasset, NY USA Show more 4 Columbia Univ, New York, NY USA Show more 5 Hanyang Univ Hosp Rheumat Dis, Seoul, South Korea Show more 6 McGill Univ, Quebec City, PQ, Canada Show more 7 Univ Manchester, Cent Manchester Univ Hosp NHS Fdn Trust, Manchester, Lancs, England Show more 8 Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England 9 New York Sch Med, New York, NY USA Show more 10 Univ Barcelona, Barcelona, Spain Show more 11 Univ Calgary, Cumming Sch Med, Calgary, AB, Canada Show more 12 Univ N Carolina, Chapel Hill, NC USA Show more 13 Univ Laval, Quebec City, PQ, Canada 14 Downstate Med Ctr Rheumatol, Brooklyn, NY USA Show more 15 Toronto Western Hosp, Krembil Res Inst, Toronto, ON, Canada Show more 16 Univ Toronto, Toronto, ON, Canada Show more 17 Nova Scotia Rehabil Ctr, Halifax, NS, Canada Show more 18 Istanbul Univ, Istanbul, Turkey Show more 19 Rigshosp, Copenhagen, Denmark 20 Med Univ South Carolina, Charleston, SC USA Show more 21 Kings Coll London, London, England Show more 22 Emory Univ, Atlanta, GA 30322 USA 23 Allegheny Hlth Network, Pittsburgh, PA USA Show more 24 Lund Univ, Lund, Sweden Show more 25 Univ Manitoba, Winnipeg, MB, Canada Show more 26 Johns Hopkins Univ, Baltimore, MD USA Show more 27 Univ Calif San Diego, San Diego, CA 92103 USA Show more 28 Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA Show more 29 Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Mexico City, DF, Mexico 30 Hosp Univ Cruces & Univ Basque Country, Baracaldo, Spain Show more 31 Mt Sinai Hosp, Toronto, ON, Canada Show more 32 Univ Hlth Network, Toronto, ON, Canada Show more 33 Univ Toronto, Toronto, ON, Canada Show more 34 Landspitali Univ Hosp, Reykjavik, Iceland Show more 35 Karolinska Univ Hosp, Solna, Sweden Show mor, University College London; London UK, The Hospital For Tropical Diseases; London UK, Feinstein Institute for Medical Research; Manhasset New York, Columbia University; New York New York, Hanyang University Hospital for Rheumatic Diseases; Seoul South Korea, McGill University; Quebec Ontario Canada, The University of Manchester; Central Manchester University Hospitals NHS Foundation Trust and Manchester Academic Health Science Centre; Manchester UK, New York School of Medicine; New York, Universitat de Barcelona; Barcelona Spain, Cumming School of Medicine; University of Calgary; Calgary Alberta Canada, University of North Carolina; Chapel Hill, Université Laval; Quebec City Québec Canada, Downstate Medical Center Rheumatology; Brooklyn New York, Krembil Research Institute; Toronto Western Hospital; University of Toronto; Toronto Ontario Canada, Nova Scotia Rehabiliation Center; Halifax Nova Scotia Canada, Istanbul University; Istanbul Turkey, Rigshospitalet; Copenhagen Denmark, Medical University of South Carolina; Charleston UK, King's College London; London UK, Emory University; Atlanta Georgia, Allegheny Health Network; Pittsburgh Pennsylvania, Lund University; Lund Sweden, University of Manitoba; Winnipeg Manitoba Canada, Johns Hopkins University; Baltimore Maryland, University of California at San Diego; Chicago Illinois, Northwestern University; Feinberg School of Medicine; Chicago Illinois, Instituto Nacional de Ciencias Médicas y Nutrición; Mexico City Mexico, Hospital Universitario Cruces and University of the Basque Country; Barakaldo Spain, Mount Sinai Hospital and University Health Network and University of Toronto; Toronto Ontario Canada, Landspitali University Hospital; Reykjavik Iceland, Karolinska University Hospital; Solna Sweden, University of California at Los Angeles; Scotland UK, Hairmyres Hospital; East Kilbride Scotland UK, Oklahoma Medical Research Foundation; Oklahoma City UK, College of Medical and Dental Sciences; University of Birmingham; Birmingham UK, Isenberg, D., Sturgess, J., Allen, E., Aranow, C., Askanase, A., Sang-Cheol, B., Bernatsky, S., Bruce, I., Buyon, J., Cervera, R., Clarke, A., Dooley, Mary Anne, Fortin, P., Ginzler, E., Gladman, D., Hanly, J., Inanc, M., Jacobsen, S., Kamen, D., Khamashta, M., Lim, S., Manzi, S., Nived, O., Peschken, C., Petri, M., Kalunian, K., Rahman, A., Ramsey-Goldman, R., Romero-Diaz, J., Ruiz-Irastorza, G., Sanchez-Guerrero, J., Steinsson, K., Sturfelt, G., Urowitz, M., Van Vollenhoven, R., Wallace, D.J., Zoma, A., Merrill, J., Gordon, C., 1 UCL, London, England Show more 2 Hosp Trop Dis, London, England Show more 3 Feinstein Inst Med Res, Manhasset, NY USA Show more 4 Columbia Univ, New York, NY USA Show more 5 Hanyang Univ Hosp Rheumat Dis, Seoul, South Korea Show more 6 McGill Univ, Quebec City, PQ, Canada Show more 7 Univ Manchester, Cent Manchester Univ Hosp NHS Fdn Trust, Manchester, Lancs, England Show more 8 Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England 9 New York Sch Med, New York, NY USA Show more 10 Univ Barcelona, Barcelona, Spain Show more 11 Univ Calgary, Cumming Sch Med, Calgary, AB, Canada Show more 12 Univ N Carolina, Chapel Hill, NC USA Show more 13 Univ Laval, Quebec City, PQ, Canada 14 Downstate Med Ctr Rheumatol, Brooklyn, NY USA Show more 15 Toronto Western Hosp, Krembil Res Inst, Toronto, ON, Canada Show more 16 Univ Toronto, Toronto, ON, Canada Show more 17 Nova Scotia Rehabil Ctr, Halifax, NS, Canada Show more 18 Istanbul Univ, Istanbul, Turkey Show more 19 Rigshosp, Copenhagen, Denmark 20 Med Univ South Carolina, Charleston, SC USA Show more 21 Kings Coll London, London, England Show more 22 Emory Univ, Atlanta, GA 30322 USA 23 Allegheny Hlth Network, Pittsburgh, PA USA Show more 24 Lund Univ, Lund, Sweden Show more 25 Univ Manitoba, Winnipeg, MB, Canada Show more 26 Johns Hopkins Univ, Baltimore, MD USA Show more 27 Univ Calif San Diego, San Diego, CA 92103 USA Show more 28 Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA Show more 29 Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Mexico City, DF, Mexico 30 Hosp Univ Cruces & Univ Basque Country, Baracaldo, Spain Show more 31 Mt Sinai Hosp, Toronto, ON, Canada Show more 32 Univ Hlth Network, Toronto, ON, Canada Show more 33 Univ Toronto, Toronto, ON, Canada Show more 34 Landspitali Univ Hosp, Reykjavik, Iceland Show more 35 Karolinska Univ Hosp, Solna, Sweden Show mor, University College London; London UK, The Hospital For Tropical Diseases; London UK, Feinstein Institute for Medical Research; Manhasset New York, Columbia University; New York New York, Hanyang University Hospital for Rheumatic Diseases; Seoul South Korea, McGill University; Quebec Ontario Canada, The University of Manchester; Central Manchester University Hospitals NHS Foundation Trust and Manchester Academic Health Science Centre; Manchester UK, New York School of Medicine; New York, Universitat de Barcelona; Barcelona Spain, Cumming School of Medicine; University of Calgary; Calgary Alberta Canada, University of North Carolina; Chapel Hill, Université Laval; Quebec City Québec Canada, Downstate Medical Center Rheumatology; Brooklyn New York, Krembil Research Institute; Toronto Western Hospital; University of Toronto; Toronto Ontario Canada, Nova Scotia Rehabiliation Center; Halifax Nova Scotia Canada, Istanbul University; Istanbul Turkey, Rigshospitalet; Copenhagen Denmark, Medical University of South Carolina; Charleston UK, King's College London; London UK, Emory University; Atlanta Georgia, Allegheny Health Network; Pittsburgh Pennsylvania, Lund University; Lund Sweden, University of Manitoba; Winnipeg Manitoba Canada, Johns Hopkins University; Baltimore Maryland, University of California at San Diego; Chicago Illinois, Northwestern University; Feinberg School of Medicine; Chicago Illinois, Instituto Nacional de Ciencias Médicas y Nutrición; Mexico City Mexico, Hospital Universitario Cruces and University of the Basque Country; Barakaldo Spain, Mount Sinai Hospital and University Health Network and University of Toronto; Toronto Ontario Canada, Landspitali University Hospital; Reykjavik Iceland, Karolinska University Hospital; Solna Sweden, University of California at Los Angeles; Scotland UK, Hairmyres Hospital; East Kilbride Scotland UK, Oklahoma Medical Research Foundation; Oklahoma City UK, College of Medical and Dental Sciences; University of Birmingham; Birmingham UK, Isenberg, D., Sturgess, J., Allen, E., Aranow, C., Askanase, A., Sang-Cheol, B., Bernatsky, S., Bruce, I., Buyon, J., Cervera, R., Clarke, A., Dooley, Mary Anne, Fortin, P., Ginzler, E., Gladman, D., Hanly, J., Inanc, M., Jacobsen, S., Kamen, D., Khamashta, M., Lim, S., Manzi, S., Nived, O., Peschken, C., Petri, M., Kalunian, K., Rahman, A., Ramsey-Goldman, R., Romero-Diaz, J., Ruiz-Irastorza, G., Sanchez-Guerrero, J., Steinsson, K., Sturfelt, G., Urowitz, M., Van Vollenhoven, R., Wallace, D.J., Zoma, A., Merrill, J., and Gordon, C.

Abstract

To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files, OBJECTIVE: To determine the level of agreement of disease flare severity (distinguishing severe, moderate, and mild flare and persistent disease activity) in a large paper-patient exercise involving 988 individual cases of systemic lupus erythematosus. METHODS: A total of 988 individual lupus case histories were assessed by 3 individual physicians. Complete agreement about the degree of flare (or persistent disease activity) was obtained in 451 cases (46%), and these provided the reference standard for the second part of the study. This component used 3 flare activity instruments (the British Isles Lupus Assessment Group [BILAG] 2004, Safety of Estrogens in Lupus Erythematosus National Assessment [SELENA] flare index [SFI] and the revised SELENA flare index [rSFI]). The 451 patient case histories were distributed to 18 pairs of physicians, carefully randomized in a manner designed to ensure a fair case mix and equal distribution of flare according to severity. RESULTS: The 3-physician assessment of flare matched the level of flare using the 3 indices, with 67% for BILAG 2004, 72% for SFI, and 70% for rSFI. The corresponding weighted kappa coefficients for each instrument were 0.82, 0.59, and 0.74, respectively. We undertook a detailed analysis of the discrepant cases and several factors emerged, including a tendency to score moderate flares as severe and persistent activity as flare, especially when the SFI and rSFI instruments were used. Overscoring was also driven by scoring treatment change as flare, even if there were no new or worsening clinical features. CONCLUSION: Given the complexity of assessing lupus flare, we were encouraged by the overall results reported. However, the problem of capturing lupus flare accurately is not completely solved.

39. The Dastatuz Project (Dastatuz)

Author

Basque Government Department of Public Health, Bioaraba Health Research Institute, Biodonostia Health Research Institute, Biocruces Bizkaia Health Research Institute, and Olaia Martinez Gonzalez, Associate Professor at the Department of Pharmacy and Food Science of the Faculty of Pharmacy at the University of the Basque Country (Universidad del País Vasco, EHU/UPV).

Published
2023

40. The Magnetic Genome of Two-Dimensional van der Waals Materials

Author

Qing Hua Wang, Amilcar Bedoya-Pinto, Mark Blei, Avalon H. Dismukes, Assaf Hamo, Sarah Jenkins, Maciej Koperski, Yu Liu, Qi-Chao Sun, Evan J. Telford, Hyun Ho Kim, Mathias Augustin, Uri Vool, Jia-Xin Yin, Lu Hua Li, Alexey Falin, Cory R. Dean, Fèlix Casanova, Richard F. L. Evans, Mairbek Chshiev, Artem Mishchenko, Cedomir Petrovic, Rui He, Liuyan Zhao, Adam W. Tsen, Brian D. Gerardot, Mauro Brotons-Gisbert, Zurab Guguchia, Xavier Roy, Sefaattin Tongay, Ziwei Wang, M. Zahid Hasan, Joerg Wrachtrup, Amir Yacoby, Albert Fert, Stuart Parkin, Kostya S. Novoselov, Pengcheng Dai, Luis Balicas, Elton J. G. Santos, Arizona State University [Tempe] (ASU), Max Planck Institute of Microstructure Physics, Instituto de Ciencia Molecular (ICMol), Universitat de València (UV), Columbia University [New York], Department of Physics [Harvard University], Harvard University, Universität Duisburg-Essen = University of Duisburg-Essen [Essen], National University of Singapore (NUS), Condensed Matter Physics and Materials Sciences Department, Brookhaven National Laboratory [Upton, NY] (BNL), UT-Battelle, LLC-Stony Brook University [SUNY] (SBU), State University of New York (SUNY)-State University of New York (SUNY)-U.S. Department of Energy [Washington] (DOE)-UT-Battelle, LLC-Stony Brook University [SUNY] (SBU), State University of New York (SUNY)-State University of New York (SUNY)-U.S. Department of Energy [Washington] (DOE), Los Alamos National Laboratory (LANL), 1. Physikalisches Institut [Stuttgart], Universität Stuttgart [Stuttgart], Kumoh National Institute of Technology [Gumi], Kumoh National Institute of Technology [Gyeongsangbuk-do], Donostia International Physics Center (DIPC), University of the Basque Country/Euskal Herriko Unibertsitatea (UPV/EHU), SUPA School of Physics and Astronomy [Edinburgh], University of Edinburgh, Department of Physics, Princeton University (DPPU), Princeton University, Institute for Frontier Materials (IFM), Deakin University [Burwood], Department of Physics, Columbia University, Ikerbasque - Basque Foundation for Science, Basque Research and Technology Alliance (BRTA), University of York [York, UK], SPINtronique et TEchnologie des Composants (SPINTEC), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), University of Manchester [Manchester], Texas Tech University [Lubbock] (TTU), Department of Physics, University of Michigan, University of Michigan [Ann Arbor], University of Michigan System-University of Michigan System, Institute for Quantum Computing [Waterloo] (IQC), University of Waterloo [Waterloo], Heriot-Watt University [Edinburgh] (HWU), Laboratory for Muon-Spin Spectroscopy (LMU), Paul Scherrer Institute (PSI), National High Magnetic Field Laboratory (NHMFL), Florida State University [Tallahassee] (FSU), Lawrence Berkeley National Laboratory [Berkeley] (LBNL), Princeton Institute for the Science and Technology of Materials, Unité mixte de physique CNRS/Thales (UMPhy CNRS/THALES), THALES [France]-Centre National de la Recherche Scientifique (CNRS), Universidad del Pais Vasco / Euskal Herriko Unibertsitatea [Espagne] (UPV/EHU), Rice University [Houston], Donostia International Physics Center - DIPC (SPAIN), University of the Basque Country/Euskal Herriko Unibertsitatea (UPV/EHU)-University of the Basque Country/Euskal Herriko Unibertsitatea (UPV/EHU), and ANR-18-CE24-0007,MAGICVALLEY,Polarisation de vallée induite par couplage d'échange magnétique dans les matériaux 2D à grande échelle(2018)

Subjects
2D magnetic materials, Magnetic Phenomena, neutron scattering, General Engineering, General Physics and Astronomy, Spintronics, Device engineering, Computing Methodologies, Magnetic imaging, atomistic spin dynamics, Topological properties, [PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci], van der Waals, Heterostructures, Quantum Theory, General Materials Science, magneto-optical effect, Spin excitations, theory
Abstract

International audience; Magnetism in two-dimensional (2D) van der Waals (vdW) materials has recently emerged as one of the most promising areas in condensed matter research, with many exciting emerging properties and significant potential for applications ranging from topological magnonics to low-power spintronics, quantum computing, and optical communications. In the brief time after their discovery, 2D magnets have blossomed into a rich area for investigation, where fundamental concepts in magnetism are challenged by the behavior of spins that can develop at the single layer limit. However, much effort is still needed in multiple fronts before 2D magnets can be routinely used for practical implementations. In this comprehensive review, prominent authors with expertise in complementary fields of 2D magnetism (i.e., synthesis, device engineering, magneto-optics, imaging, transport, mechanics, spin excitations, and theory and simulations) have joined together to provide a genome of current knowledge and a guideline for future developments in 2D magnetic materials research.

Published
2022
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41. Phase diagram of twisted bilayer graphene at filling factor ν = ± 3

Author

Fang Xie, Jian Kang, B. Andrei Bernevig, Oskar Vafek, Nicolas Regnault, Department of Physics, Princeton University (DPPU), Princeton University, Rice University [Houston], ShanghaiTech University [Shanghai], Donostia International Physics Center - DIPC (SPAIN), Donostia International Physics Center (DIPC), University of the Basque Country/Euskal Herriko Unibertsitatea (UPV/EHU)-University of the Basque Country/Euskal Herriko Unibertsitatea (UPV/EHU), Ikerbasque - Basque Foundation for Science, National High Magnetic Field Laboratory (NHMFL), Florida State University [Tallahassee] (FSU), Théorie de la Matière Condensée, Laboratoire de physique de l'ENS - ENS Paris (LPENS), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Département de Physique de l'ENS-PSL, École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Département de Physique de l'ENS-PSL, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), European Project: 101017733 ,QuantERA II, European Project: 731473,QuantERA, and European Project: 101020833,SuperFlat

Subjects
Condensed Matter - Strongly Correlated Electrons, Condensed Matter - Mesoscale and Nanoscale Physics, [PHYS.COND.CM-SCE]Physics [physics]/Condensed Matter [cond-mat]/Strongly Correlated Electrons [cond-mat.str-el]
Abstract

We study the correlated insulating phases of twisted bilayer graphene (TBG) in the absence of lattice strain at integer filling $\nu=\pm3$. Using the self-consistent Hartree-Fock method on a particle-hole symmetric model and allowing translation symmetry breaking terms, we obtain the phase diagram with respect to the ratio of $AA$ interlayer hopping $(w_0)$ and $AB$ interlayer hopping $(w_1)$. When the interlayer hopping ratio is close to the chiral limit ($w_0/w_1 \lesssim 0.5$), a quantum anomalous Hall state with Chern number $\nu_c = \pm 1$ can be observed consistent with previous studies. Around the realistic value $w_0/w_1 \approx 0.8$, we find a spin and valley polarized, translation symmetry breaking, state with $C_{2z}T$ symmetry, a charge gap and a doubling of the moir\'e unit cell, dubbed the $C_{2z}T$ stripe phase. The real space total charge distribution of this $C_{2z}T$ stripe phase in the flat band limit does not have modulation between different moir\'e unit cells, although the charge density in each layer is modulated, and the translation symmetry is strongly broken. Other symmetries, including $C_{2z}$, $C_{2x}$ and particle-hole symmetry $P$, and the topology of the $C_{2z}T$ stripe phase are also discussed in detail. We observed braiding and annihilation of the Dirac nodes by continuously turning on the order parameter to its fully self-consistent value, and provide a detailed explanation of the mechanism for the charge gap opening despite preserving $C_{2z}T$ and valley $U(1)$ symmetries. In the transition region between the quantum anomalous Hall phase and the $C_{2z}T$ stripe phase, we find an additional competing state with comparable energy corresponding to a phase with a tripling of the moir\'e unit cell., Comment: 39 pages, 33 figures

Published
2023
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42. SuperpixelGridMasks Data Augmentation:Application to Precision Health and Other Real-world Data

Author

Karim Hammoudi, Adnane Cabani, Bouthaina Slika, Halim Benhabiles, Fadi Dornaika, Mahmoud Melkemi, Institut de Recherche en Informatique Mathématiques Automatique Signal - IRIMAS - UR 7499 [IRIMAS], École Supérieure d’Ingénieurs en Génie Électrique [ESIGELEC], Euskal Herriko Unibertsitatea [Guipúzcoa] [EHU], University of the Basque Country/Euskal Herriko Unibertsitatea [UPV/EHU], Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN], Bio-Micro-Electro-Mechanical Systems - IEMN [BIOMEMS - IEMN], JUNIA [JUNIA], Institut de Recherche en Informatique Mathématiques Automatique Signal - IRIMAS - UR 7499 (IRIMAS), Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA)), École Supérieure d’Ingénieurs en Génie Électrique (ESIGELEC), Euskal Herriko Unibertsitatea [Guipúzcoa] (EHU), Universidad del Pais Vasco / Euskal Herriko Unibertsitatea [Espagne] (UPV/EHU), University of the Basque Country/Euskal Herriko Unibertsitatea (UPV/EHU), Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), Bio-Micro-Electro-Mechanical Systems - IEMN (BIOMEMS - IEMN), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), JUNIA (JUNIA), and Université catholique de Lille (UCL)

Subjects
[SPI]Engineering Sciences [physics], Artificial Intelligence, Health Informatics, Computer Science Applications, Information Systems
Abstract

ressources projet: https://github.com/hammoudiproject/SuperpixelGridMasksdatasets used for the article: 1 Dataset Chest X-Ray Images: https://www.kaggle.com/datasets/paultimothymooney/chest-xray-pneumonia2 A PASCAL VOC dataset: http://host.robots.ox.ac.uk/pascal/VOC/databases.html#VOC2005_1; International audience; A novel approach of data augmentation based on irregular superpixel decomposition is proposed. This approach called SuperpixelGridMasks permits to extend original image datasets that are required by training stages of machine learning-related analysis architectures towards increasing their performances. Three variants named SuperpixelGridCut, SuperpixelGridMean, and SuperpixelGridMix are presented. These grid-based methods produce a new style of image transformations using the dropping and fusing of information. Extensive experiments using various image classification models as well as precision health and surrounding real-world datasets show that baseline performances can be significantly outperformed using our methods. The comparative study also shows that our methods can overpass the performances of other data augmentations. SuperpixelGridCut, SuperpixelGridMean, and SuperpixelGridMix codes are publicly available at https://github.com/hammoudiproject/SuperpixelGridMasks.

Published
2023
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43. Characterization of a functional V1B vasopressin receptor in the male rat kidney: evidence for cross talk between V1B and V2 receptor signaling pathways

Author

Claudine Serradeil-Le Gal, Maithé Corbani, Catherine Llorens-Cortes, Nadine Bouby, Annette Hus-Citharel, Csaba Tömböly, Christiane Mendre, Miguel Trueba, Gilles Guillon, Judit Darusi, Julie Mion, Neuropeptides centraux et régulations hydrique et cardiovasculaire, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre interdisciplinaire de recherche en biologie (CIRB), Labex MemoLife, École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Collège de France (CdF (institution))-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Collège de France (CdF (institution))-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Labex MemoLife, Université Paris sciences et lettres (PSL)-Collège de France (CdF (institution))-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP), Institut de Génomique Fonctionnelle (IGF), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), Biological Research Center [Hungarian Academy of Sciences], University of the Basque Country [Bizkaia] (UPV/EHU), VibioSphen, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Collège de France (CdF (institution))-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Labex MemoLife, Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hungarian Academy of Sciences (MTA), and University of the Basque Country/Euskal Herriko Unibertsitatea (UPV/EHU)

Subjects
0301 basic medicine, Physiology, [SDV]Life Sciences [q-bio], 030232 urology & nephrology, Rat kidney, Diuresis, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, Vasopressin V1B and V2 receptor, 03 medical and health sciences, 0302 clinical medicine, Arginine vasopressin receptor 2, medicine, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Receptor, receptor heterodimerization, Arginine vasopressin receptor 1B, Messenger RNA, Kidney, Chemistry, vasopressin V1B and V2 receptors, inner medullary collecting duct, calcium and cAMP signaling, Cell biology, diuresis, 030104 developmental biology, medicine.anatomical_structure, Signal transduction
Abstract

International audience; Although vasopressin V1B receptor (V1BR) mRNA has been detected in the kidney, the precise renal localization as well as pharmacological and physiological properties of this receptor remain unknown. Using the selective V1B agonist d[Leu4, Lys8]VP, either fluorescent or radioactive, we showed that V1BR is mainly present in principal cells of the inner medullary collecting duct (IMCD) in the male rat kidney. Protein and mRNA expression of V1BR were very low compared with the V2 receptor (V2R). On the microdissected IMCD, d[Leu4, Lys8]VP had no effect on cAMP production but induced a dose-dependent and saturable intracellular Ca2+ concentration increase mobilization with an EC50 value in the nanomolar range. This effect involved both intracellular Ca2+ mobilization and extracellular Ca2+ influx. The selective V1B antagonist SSR149415 strongly reduced the ability of vasopressin to increase intracellular Ca2+ concentration but also cAMP, suggesting a cooperation between V1BR and V2R in IMCD cells expressing both receptors. This cooperation arises from a cross talk between second messenger cascade involving PKC rather than receptor heterodimerization, as supported by potentiation of arginine vasopressin-stimulated cAMP production in human embryonic kidney-293 cells coexpressing the two receptor isoforms and negative results obtained by bioluminescence resonance energy transfer experiments. In vivo, only acute administration of high doses of V1B agonist triggered significant diuretic effects, in contrast with injection of selective V2 agonist. This study brings new data on the localization and signaling pathways of V1BR in the kidney, highlights a cross talk between V1BR and V2R in the IMCD, and suggests that V1BR may counterbalance in some pathophysiological conditions the antidiuretic effect triggered by V2R activation.NEW & NOTEWORTHY Although V1BR mRNA has been detected in the kidney, the precise renal localization as well as pharmacological and physiological properties of this receptor remain unknown. Using original pharmaceutical tools, this study brings new data on the localization and signaling pathways of V1BR, highlights a cross talk between V1BR and V2 receptor (V2R) in the inner medullary collecting duct, and suggests that V1BR may counterbalance in some pathophysiological conditions the antidiuretic effect triggered by V2R activation.

Published
2021
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44. Automatically weighted binary multi-view clustering via deep initialization (AW-BMVC)

Author

Khamis Houfar, Djamel Samai, Fadi Dornaika, Azeddine Benlamoudi, Khaled Bensid, Abdelmalik Taleb-Ahmed, Université Kasdi Merbah Ouargla, Universitat Autònoma de Barcelona (UAB), Ikerbasque - Basque Foundation for Science, University of the Basque Country/Euskal Herriko Unibertsitatea (UPV/EHU), Center for Machine Vision Research (CMV), University of Oulu, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), COMmunications NUMériques - IEMN (COMNUM - IEMN), INSA Institut National des Sciences Appliquées Hauts-de-France (INSA Hauts-De-France), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université Polytechnique Hauts-de-France (UPHF), The authors gratefully acknowledge the Directorate General for Scientific Research and Technological Development (DGRSDT) of Algeria for the financial support to this work. This work is part of the grant PID2021-126701OB-I00 funded by MCIN/AEI/10.13039/501100011033 and by ERDF A way of making Europe., Universitat Autònoma de Barcelona [UAB], University of the Basque Country/Euskal Herriko Unibertsitatea [UPV/EHU], Center for Machine Vision Research [CMV], Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN], COMmunications NUMériques - IEMN [COMNUM - IEMN], and Université Polytechnique Hauts-de-France [UPHF]

Subjects
[SPI]Engineering Sciences [physics], Discrete representation, Artificial Intelligence, Multi-view clustering, Anchors, Signal Processing, BD-FFT, Large scale, Computer Vision and Pattern Recognition, Software
Abstract

International audience; Clustering is inherently a process of exploratory data analysis. It has attracted more attention recently because much real-world data consists of multiple representations or views. However, it becomes increasingly problematic when dealing with large and heterogeneous data. It is worth noting that several approaches have been developed to increase computational efficiency, although most of them have some drawbacks: (1) Most existing techniques consider equal or static weights to quantify importance across different views and samples, so common and complementary features cannot be used. (2) The clustering task is performed by arbitrary initialization without caring about the rich structure of the joint discrete representation, and thus poorly executed. In this paper, we propose a novel approach called “Auto-Weighted Binary Multi-View Clustering Via Deep Initialization” for large-scale multi-view clustering based on two main scenarios. First, we consider the distinction between different views based on the importance of samples, and therefore apply a dynamic learning strategy for the automatic weighting of views and samples. Second, in the context of initializing binary clustering, we develop a new CNN feature and use a low-dimensional binary embedding by exploiting the efficient capabilities of Fourier mapping. Moreover, our approach simultaneously learns a joint discrete representation and performs direct clustering using a constrained binary matrix factorization; the optimization problem is perfectly solved in a unified learning model. Experimental results conducted on several challenging datasets demonstrate the effectiveness and superiority of the proposed approach over state-of-the-art methods in terms of accuracy, normalized mutual information, and purity.

Published
2023
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45. Spatial organization of neuron-astrocyte interactions in the somatosensory cortex

Author

Andrés M. Baraibar, Lindsey Belisle, Giovanni Marsicano, Carlos Matute, Susana Mato, Alfonso Araque, Paulo Kofuji, University of the Basque Country/Euskal Herriko Unibertsitatea (UPV/EHU), Achucarro Basque Center for Neuroscience [Leioa, Spain] (ABCN), University of the Basque Country, University of Minnesota [MN, USA], Biocruces Bizkaia Health Research Institute [Baracaldo], Centro de Investigacion Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III [Madrid] (ISC), Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale (U1215 Inserm - UB), Université de Bordeaux (UB)-Institut François Magendie-Institut National de la Santé et de la Recherche Médicale (INSERM), and Admin, Oskar

Subjects
Cellular and Molecular Neuroscience, nervous system, Neuron-astrocyte communication, Cognitive Neuroscience, Calcium imaging, Cortex, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Synaptic transmission, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Astrocyte
Abstract

Microcircuits in the neocortex are functionally organized along layers and columns, which are the fundamental modules of cortical information processing. While the function of cortical microcircuits has focused on neuronal elements, much less is known about the functional organization of astrocytes and their bidirectional interaction with neurons. Here, we show that Cannabinoid type 1 receptor (CB1R)-mediated astrocyte activation by neuron-released endocannabinoids elevate astrocyte Ca2+ levels, stimulate ATP/adenosine release as gliotransmitters, and transiently depress synaptic transmission in layer 5 pyramidal neurons at relatively distant synapses (˃20 μm) from the stimulated neuron. This astrocyte-mediated heteroneuronal synaptic depression occurred between pyramidal neurons within a cortical column and was absent in neurons belonging to adjacent cortical columns. Moreover, this form of heteroneuronal synaptic depression occurs between neurons located in particular layers, following a specific connectivity pattern that depends on a layer-specific neuron-to-astrocyte signaling. These results unravel the existence of astrocyte-mediated nonsynaptic communication between cortical neurons and that this communication is column- and layer-specific, which adds further complexity to the intercellular signaling processes in the neocortex.

Published
2022

46. A comparative study of human facial age estimation: handcrafted features vs. deep features

Author

Abdelkrim Ouafi, Salah Eddine Bekhouche, Fadi Dornaika, Azeddine Benlamoudi, Abdelmalik Taleb-Ahmed, Laboratory of Development in Mechanics and Materials, University of Djelfa, Algeria (LDMM), Speech Interactive Research Group (RG) (University of the Basque Country / Universidad del País Vasco (UPV/EHU)), University of Kasdi Merbah Ouargla, Laboratoire Energie Signal Images et Automatique [Univ Ngaoundéré] (LESIA), Université de Ngaoundéré/University of Ngaoundéré [Cameroun] (UN), Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), COMmunications NUMériques - IEMN (COMNUM - IEMN), Institut d’Électronique, de Microélectronique et de Nanotechnologie - Département Opto-Acousto-Électronique - UMR 8520 (IEMN-DOAE), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-INSA Institut National des Sciences Appliquées Hauts-de-France (INSA Hauts-De-France)-Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-INSA Institut National des Sciences Appliquées Hauts-de-France (INSA Hauts-De-France), University of the Basque Country/Euskal Herriko Unibertsitatea (UPV/EHU), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), and Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)

Subjects
Biometrics, Computer Networks and Communications, Computer science, Feature extraction, 02 engineering and technology, [INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI], [INFO.INFO-NI]Computer Science [cs]/Networking and Internet Architecture [cs.NI], Deep features, [SPI]Engineering Sciences [physics], Pyramid, 0202 electrical engineering, electronic engineering, information engineering, Media Technology, [INFO]Computer Science [cs], Pyramid (image processing), Representation (mathematics), business.industry, 020207 software engineering, Pattern recognition, 16. Peace & justice, [SPI.TRON]Engineering Sciences [physics]/Electronics, Handcrafted features, Support vector machine, Support vector regression, Hardware and Architecture, Face (geometry), Age estimation, Artificial intelligence, business, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, Software
Abstract

International audience; In recent times, the topic of human facial age estimation attracted much attention. This is due to its ability to improve biometrics systems. Recently, several applications that are based on the demographic attributes estimation have been developed. These include law enforcement, re-identification in videos, planed marketing, intelligent advertising, social media, and human-computer interaction. The main contributions of the paper are as follows. Firstly, it extends some handcrafted models that are based on the Pyramid Multi Level (PML) face representation. Secondly, it evaluates the performance of two different kinds of features that are handcrafted and deep features. It compares handcrafted and deep features in terms of accuracy and computational complexity. The proposed scheme of study includes the following three main steps: 1) face preprocessing; 2) feature extraction (two different kinds of features are studied: handcrafted and deep features); 3) feeding the obtained features to a linear regressor. In addition, we investigate the strengths and weaknesses of handcrafted and deep features when used in facial age estimation. Experiments are run on three public databases (FG-NET, PAL and FACES). These experiments show that both handcrafted and deep features are effective for facial age estimation.

Published
2020
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47. Arboreal Tradition and Subversion: An Ecocritical Reading of Shakespeare’s Portrayal of Trees, Woods and Forests

Author

Martin Simonson, Andoni Cossio, Cossio, Andoni - University of the Basque Country (UPV/EHU), Spain, Simonson, Martin - University of the Basque Country (UPV/EHU), Spain, Cossio, Andoni - andoni.cossio@ehu.eus, and Simonson, Martin - martin.simonson@ehu.eus

Subjects
Cultural Studies, Linguistics and Language, Arboreal locomotion, History, Shakespeare, Literature and Literary Theory, Visual Arts and Performing Arts, media_common.quotation_subject, shakespeare, tradition, subversion, English literature, Language and Linguistics, woods, Ecocriticism, Meaning (existential), Subversion, Hamlet (place), media_common, forests, ecocriticism, trees, Magic (paranormal), Aesthetics, Close reading, Tempest, PR1-9680
Abstract

This paper analyses from an ecocritical standpoint the role of trees, woods and forests and their symbolism in William Shakespeare’s Hamlet, Macbeth, The Merchant of Venice, The Merry Wives of Windsor, A Midsummer Night’s Dream, Richard II and The Tempest. The analysis begins with an outline of the representation of trees on stage to continue with a ‘close reading’ of the mentioned plays, clearly distinguishing individual trees from woods and forests. Individual types of trees may represent death, sadness, sorcery and premonitions, or serve as meeting places, while forests and woods are frequently portrayed as settings which create an atmosphere of confusion, false appearances, danger and magic. This reflects a long-standing historical connection between trees and forests and the supernatural in literature and culture. However, while individual trees largely reflect traditional symbology, conventional interpretations are often subverted in Shakespeare’s treatment of forests and woods. From all this we may infer that Shakespeare was not only familiar with the traditions associated to individual tree species and forests in general, but also that he made conscious and active use of these in order to enhance the meaning of an action, reinforce character traits, further the plot and create a specific atmosphere. More subtly, the collective arboreal environments can also be interpreted as spaces in which superstitions and older societal models are questioned in favour of a more rational and reasonable understanding of the world. This essay was completed under the auspices of the Pre-doctoral Funding (PRE_2017_1_0210 MOD.:A), awarded by the Basque Government, and REWEST research group (IT 1026-16), funded by the Basque Government and the University of the Basque Country (UPV/EHU). It was also financed by the research project “New Wests” (PGC2018-094659-B-C2), sponsored by the Ministry of Science and Innovation, Government of Spain.

Published
2020

48. Quantum crystal structure in the 250-kelvin superconducting lanthanum hydride

Author

Ryotaro Arita, José A. Flores-Livas, Terumasa Tadano, Takashi Koretsune, Matteo Calandra, Francesco Mauri, Lorenzo Monacelli, Antonio Sanna, Raffaello Bianco, Francesco Belli, Ion Errea, European Commission, Donostia International Physics Center - DIPC (SPAIN), Donostia International Physics Center (DIPC), University of the Basque Country/Euskal Herriko Unibertsitatea (UPV/EHU)-University of the Basque Country/Euskal Herriko Unibertsitatea (UPV/EHU), Spectroscopie des nouveaux états quantiques (INSP-E2), Institut des Nanosciences de Paris (INSP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Dipartimento di Fisica, Universita di Roma La Sapienza, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Max-Planck-Institut für Mikrostrukturphysik (MPI-HALLE), Max-Planck-Gesellschaft, European Research Council, Ministerio de Economía y Competitividad (España), Ministry of Education, Culture, Sports, Science and Technology (Japan), and Swiss National Science Foundation

Subjects
High-pressure, Ab initio, FOS: Physical sciences, 02 engineering and technology, Crystal structure, 7. Clean energy, 01 natural sciences, Superconductivity (cond-mat.supr-con), Condensed Matter::Superconductivity, 0103 physical sciences, [PHYS.COND]Physics [physics]/Condensed Matter [cond-mat], 010306 general physics, Quantum, Quantum fluctuation, [PHYS]Physics [physics], Physics, Superconductivity, Condensed Matter - Materials Science, Multidisciplinary, Condensed matter physics, superconductivity, Condensed Matter - Superconductivity, Hydrides, Materials Science (cond-mat.mtrl-sci), Energy landscape, Quantum effects, 021001 nanoscience & nanotechnology, Coupling (probability), High-temperature superconductivity, 0210 nano-technology, Ground state
Abstract

arXiv:1907.11916v1, The discovery of superconductivity at 200 kelvin in the hydrogen sulfide system at high pressures demonstrated the potential of hydrogen-rich materials as high-temperature superconductors. Recent theoretical predictions of rare-earth hydrides with hydrogen cages and the subsequent synthesis of LaH10 with a superconducting critical temperature (Tc) of 250 kelvin have placed these materials on the verge of achieving the long-standing goal of room-temperature superconductivity. Electrical and X-ray diffraction measurements have revealed a weakly pressure-dependent Tc for LaH10 between 137 and 218 gigapascals in a structure that has a face-centred cubic arrangement of lanthanum atoms. Here we show that quantum atomic fluctuations stabilize a highly symmetrical Fm3¯¯¯m crystal structure over this pressure range. The structure is consistent with experimental findings and has a very large electron–phonon coupling constant of 3.5. Although ab initio classical calculations predict that this Fm3¯¯¯m structure undergoes distortion at pressures below 230 gigapascals, yielding a complex energy landscape, the inclusion of quantum effects suggests that it is the true ground-state structure. The agreement between the calculated and experimental Tc values further indicates that this phase is responsible for the superconductivity observed at 250 kelvin. The relevance of quantum fluctuations calls into question many of the crystal structure predictions that have been made for hydrides within a classical approach and that currently guide the experimental quest for room-temperature superconductivity. Furthermore, we find that quantum effects are crucial for the stabilization of solids with high electron–phonon coupling constants that could otherwise be destabilized by the large electron–phonon interaction9, thus reducing the pressures required for their synthesis., This research was supported by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement no. 802533); the Spanish Ministry of Economy and Competitiveness (FIS2016-76617-P); Grant-in-Aid for Scientific Research (number 16H06345, 18K03442 and 19H05825) from the Ministry of Education, Culture, Sports, Science and Technology, Japan; and NCCR MARVEL funded by the Swiss National Science Foundation. Computational resources were provided by the Barcelona Superconducting Center (project FI-2019-1-0031) and the Swiss National Supercomputing Center (CSCS) with project s970.

Published
2020
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49. Prevalence and Clinical Outcomes of Poor Immune Response Despite Virologically Suppressive Antiretroviral Therapy Among Children and Adolescents With Human Immunodeficiency Virus in Europe and Thailand: Cohort Study

Author

Chappell, E., Riordan, A., Jourdain, G., Soriano-Arandes, A., Ene, L., Scherpbier, H., Warszawski, J., Collins, I., Smit, C., Marques, L., Klein, N., Guillén, S., Judd, A., Thorne, C., Goodall, R., Königs, C., Spoulou, V., Prata, F., Goetghebuer, T., Chiappini, E., Galli, L., Naver, L., Giaquinto, C., Gibb, D., Marczynska, M., Okhonskaia, L., Klimkait, T., Lallemant, M., Ngo-Giang-Huong, N., Kiseleva, G., Malyuta, R., Volokha, A., Hainaut, M., Delforge, M., Le Chenadec, J., Ramos, E., Dialla, O., Wack, T., Laurent, C., Ait Si Selmi, L., Leymarie, I., Ait Benali, F., Brossard, M., Boufassa, L., Floch-Tudal, C., Firtion, G., Hau, I., Chace, A., Bolot, P., Blanche, S., Levine, M., Bicëtre, L., Fourcade, C., Heller-Roussin, B., Runel-Belliard, C., Tricoire, J., Chirouze, C., Reliquet, V., Brouard, J., Kebaili, K., Fialaire, P., Lalande, M., Schultze-Strasser, S., Baumann, U., Niehues, T., Neubert, J., Kobbe, R., Berlin, C., Feiterna-Sperling, C., Buchholz, B., Notheis, G., de Martino, M., Angelo Tovo, P., Patrizia, O., Larovere, D., Ruggeri, M., Faldella, G., Baldi, F., Badolato, R., Montagnani, C., Venturini, E., Lisi, C., Di Biagio, A., Taramasso, L., Giacomet, V., Erba, P., Esposito, S., Lipreri, R., Salvini, F., Tagliabue, C., Cellini, M., Bruzzese, E., Lo Vecchio, A., Rampon, O., Donà, D., Romano, A., Dodi, I., Maccabruni, A., Consolini, R., Bernardi, S., Tchidjou Kuekou, H., Genovese, O., Olmeo, P., Cristiano, L., Mazza, A., Gabiano, C., Garazzino, S., Pellegatta, A., Pajkrt, D., Weijsenfeld, A., de Boer CG, Jurriaans, S., Back, N., Zaaijer, H., Berkhout, B., Cornelissen, M., Schinkel, C., Wolthers, K., Fraaij, P., van Rossum AMC, van der Knaap LC, Visser, E., Koopmans, M., van Kampen JJA, Pas, S., Henriet, S., van de Flier, M., van Aerde, K., Strik-Albers, R., Rahamat-Langendoen, J., Stelma, F., Schölvinck, E., de Groot-de Jonge, H., Niesters, H., van Leer-Buter CC, Knoester, M., Bont, L., Geelen, S., Wolfs, T., Nauta, N., Ang, C., van Houdt, R., Pettersson, A., Vandenbroucke-Grauls, C., Reiss, P., Bezemer, D., van Sighem AI, Wit, F., Boender, T., Zaheri, S., Hillebregt, M., de Jong, A., Bergsma, D., Grivell, S., Jansen, A., Raethke, M., Meijering, R., de Groot, L., van den Akker, M., Bakker, Y., Claessen, E., El Berkaoui, A., Koops, J., Kruijne, E., Lodewijk, C., Munjishvili, L., Peeck, B., Ree, C., Regtop, R., Ruijs, Y., Rutkens, T., Schoorl, M., Timmerman, A., Tuijn, E., Veenenberg, L., van der Vliet, S., Wisse, A., Woudstra, T., Tuk, B., Popielska, J., Pokorska-Śpiewak, M., Ołdakowska, A., Zawadka, K., Coupland, U., DorobaLaura Marques, M., Teixeira, C., Fernandes, A., Voronin, E., Miloenko, M., Labutina, S., Tomás Ramos, J., Prieto, L., Luisa Navarro, M., Saavedra, J., Santos, M., Angeles Muñoz, M., Ruiz, B., Mc Phee CF, de Ory SJ, Alvarez, S., Ángel Roa, M., Beceiro, J., Martínez, J., Badillo, K., Apilanez, M., Pocheville, I., Garrote, E., Colino, E., Gómez Sirvent, J., Garzón, M., Román, V., Montesdeoca, A., Mateo, M., José Muñoz, M., Angulo, R., Neth, O., Falcón, L., Terol, P., Luis Santos, J., Moreno, D., Lendínez, F., Grande, A., José Romero, F., Lillo, M., Losada, B., Herranz, M., Bustillo, M., Guerrero, C., Collado, P., Antonio Couceiro, J., Pérez, A., Isabel Piqueras, A., Bretón, R., Segarra, I., Gavilán, C., Jareño, E., Montesinos, E., Dapena, M., Álvarez, C., Gloria Andrés, A., Marugán, V., Ochoa, C., Alfayate, S., Isabel Menasalvas, A., de Miguel, E., Aebi-Popp, K., Asner, S., Aubert, V., Battegay, M., Baumann, M., Bernasconi, E., Böni, J., Brazzola, P., Bucher, H., Calmy, A., Cavassini, M., Ciuffi, A., Duppenthaler, A., Dollenmaier, G., Egger, M., Elzi, L., Fehr, J., Fellay, J., Francini, K., Furrer, H., Fux, C., Grawe, C., Günthard, H., Haerry, D., Hasse, B., Hirsch, H., Hoffmann, M., Hösli, I., Kahlert, C., Kaiser, L., Keiser, O., Kovari, H., Kouyos, R., Ledergerber, B., Martinetti, G., de Tejada BM, Metzner, K., Müller, N., Nicca, D., Paioni, P., Pantaleo, G., Polli, C., Posfay-Barbe, K., Rauch, A., Rudin, C., Schmid, P., Scherrer, A., Speck, R., Tarr, P., Thanh Lecompte, M., Trkola, A., Vernazza, P., Wagner, N., Wandeler, G., Weber, R., Wyler, C., Yerly, S., Techakunakorn, P., Hansudewechakul, R., Kham, C., Wanchaitanawong, V., Theansavettrakul, S., Sai, M., Nanta, S., Ngampiyaskul, C., Phanomcheong, S., Hongsiriwon, S., Karnchanamayul, W., Kwanchaipanich, R., Kanjanavanit, S., Kamonpakorn, N., Nantarukchaikul, M., Layangool, P., Mekmullica, J., Lucksanapisitkul, P., Watanayothin, S., Lertpienthum, N., Warachit, B., Hanpinitsak, S., Potchalongsin, S., Thanasiri, P., Krikajornkitti, S., Attavinijtrakarn, P., Srirojana, S., Bunjongpak, S., Puangsombat, A., Na-Rajsima, S., Ananpatharachai, P., Akarathum, N., Phuket, V., Lawtongkum, W., Kheunjan, P., Suriyaboon, T., Saipanya, A., Than-In-At, K., Jaisieng, N., Suaysod, R., Chailoet, S., Naratee, N., Kawilapat, S., Kaleeva, T., Baryshnikova, Y., Soloha, S., Bashkatova, N., Raus, I., Glutshenko, O., Ruban, Z., Prymak, N., Bailey, H., Bamford, A., Butler, K., Doerholt, K., Doherty, C., Foster, C., Francis, K., Harrison, I., Kenny, J., Letting, G., Mcmaster, P., Murau, F., Nsangi, E., Peters, H., Prime, K., Shackley, F., Shingadia, D., Storey, S., Tudor-Williams, G., Turkova, A., Welch, S., Jeannie Collins, I., Cook, C., Crichton, S., Dobson, D., Fairbrother, K., M Gibb D, Harper, L., Le Prevost, M., Van Looy, N., Walsh, A., Thrasyvoulou, L., Bernatoniene, J., Manyika, F., Sharpe, G., Subramaniam, B., Sloper, K., Fidler, K., Hague, R., Price, V., Clapson, M., Flynn, J., Cardoso, A., Abou-Rayyah, M., Gurtin, D., Yeadon, S., Segal, S., Ball, C., Hawkins, S., Dowie, M., Bandi, S., Percival, E., Eisenhut, M., Duncan, K., Clough, S., Anguvaa, L., Conway, S., Flood, T., Pickering, A., Murphy, C., Daniels, J., Lees, Y., Thompson, F., Williams, B., Pope, S., Cliffe, L., Smyth, A., Southall, S., Freeman, A., Freeman, H., Christie, S., Gordon, A., Rogahn, D., Clarke, L., Jones, L., Offerman, B., Greenberg, M., Benson, C., Ibberson, L., Faust, S., Hancock, J., Sharland, M., Lyall, H., Monrose, C., Seery, P., Menson, E., Callaghan, A., Bridgwood, A., Evans, J., Blake, E., Yannoulias, A., Critchton, S., Duff, C., Gomezpena, D., Lundin, R., Mangiarini, L., Nardone, A., Posfay Barbe, Klara, Universidad de Alcalá - University of Alcalá (UAH), Department of Sciences for Woman and Child's Health, Università degli Studi di Firenze = University of Florence (UniFI), Épidémiologie clinique, santé mère-enfant et VIH en Asie du Sud-Est (IRD_PHPT), Harvard University-Chiang Mai University (CMU), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier de Saint-Denis [Ile-de-France], CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Laboratoire Chrono-environnement (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), service de maladies infectieuses CHU J Minjoz Besancon, Service des maladies infectieuses et tropicales [CHU Nantes], Centre hospitalier universitaire de Nantes (CHU Nantes), Service de Pédiatrie Médicale [Caen], Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Service d'hématologie : Immuno-Hématologie pédiatrique et transplantation de moelle osseuse, Hôpital Debrousse, Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Universitätsklinikum Frankfurt, Infectious Diseases, San Martino Hospital, Università degli studi di Genova = University of Genoa (UniGe), Department of Maternal and Pediatric Sciences, University of Milan, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Maternal-Infantile Department, Unit of Paediatrics and Oncohematology, University Hospital of Parma, Department of Infectious Diseases, IRCCS S. Matteo, Department of Paediatrics, Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma] (Unicatt), Dipartimento di Ingegneria [Benevento], Università degli Studi del Sannio, University of Twente, Institut de génétique humaine (IGH), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Laboratory for Infectious Diseases and Perinatal Screening, Center for Infectious Disease Control, National Institute for Public Health and the Environment [Bilthoven] (RIVM), Architecture et réactivité de l'ARN (ARN), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Synthèse, Structure et Propriétés de Matériaux Fonctionnels (STEP), SYstèmes Moléculaires et nanoMatériaux pour l’Energie et la Santé (SYMMES), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Département Interfaces pour l'énergie, la Santé et l'Environnement (DIESE), Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Stichting HIV Monitoring, Universidade Federal do Ceará = Federal University of Ceará (UFC), Departamento de Química Orgánica, Universidade de Vigo, Polytechnical University of Valencia, Fac Biol, Dept Genet, Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] (UCM), University of the Basque Country/Euskal Herriko Unibertsitatea (UPV/EHU), Service des maladies infectieuses, Hôpitaux Universitaires de Genève (HUG), University of Basel (Unibas), Dysfonctions métaboliques et diabètes: Mécanismes et approches thérapeutiques, Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-IFR50-Institut National de la Santé et de la Recherche Médicale (INSERM), University Heart Centre Freiburg - Bad Krozingen, Prapokklao Hospital [Chanthaburi, Thailand], Nakornping Hospital [Chiang Mai, Thailand], Samutsakhon Hospital [Samutsakhon, Thailand], Kalasin Hospital [Kalasin, Thailand], Sanpatong Hospital [Chiang Mai, Thailand], Chiang Mai University (CMU), Microbiology Department, St. Jame's Hospital, University of Edinburgh, Infectious Diseases and Microbiology Unit, Great Ormond Street Hospital for Children [London] (GOSH)-Institute of Child Health, European Synchrotron Radiation Facility (ESRF), Centre for Ecology and Hydrology [Bangor] (CEH), Natural Environment Research Council (NERC), Jet Propulsion Laboratory (JPL), NASA-California Institute of Technology (CALTECH), University of London [London], London South Bank University (LSBU), Dipartimento di Pediatria, Azienda Ospedaliera di Padova, Université Grenoble Alpes - UFR Pharmacie (UGA UFRP), Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), The European Pregnancy and Paediatric HIV Cohort Collaboration (EPPICC) Study Group in EuroCoord, Florence University, Harvard University [Cambridge]-Chiang Mai University (CMU), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), University of Genoa (UNIGE), Catholic University of Rome, University of Twente [Netherlands], Institut de Chimie du CNRS (INC)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), University of the Basque Country [Bizkaia] (UPV/EHU), Université Nice Sophia Antipolis (... - 2019) (UNS), Pediatrics, Virology, Chappell, Elizabeth, Riordan, Andrew, Jourdain, Gonzague, Soriano-Arandes, Antoni, Ene, Luminita, J Scherpbier, Henriette, Warszawski, Josiane, J Collins, Intira, Smit, Colette, Marques, Laura, Klein, Nigel, Guillén, Sara, Judd, Ali, Thorne, Claire, Goodall, Ruth, Königs, Christoph, Spoulou, Vana, Prata, Filipa, Goetghebuer, Tessa, Chiappini, Elena, Galli, Luisa, Naver, Lar, Giaquinto, Carlo, M Gibb, Diana, Marczynska, Magdalena, Okhonskaia, Liubov, Klimkait, Thoma, Lallemant, Marc, Ngo-Giang-Huong, Nicole, Kiseleva, Galyna, Malyuta, Ruslan, Volokha, Alla, Hainaut, Marc, Delforge, Marc, Le Chenadec, Jerome, Ramos, Elisa, Dialla, Olivia, Wack, Thierry, Laurent, Corine, Ait Si Selmi, Lamya, Leymarie, Isabelle, Ait Benali, Fazia, Brossard, Maud, Boufassa, Leila, Floch-Tudal, Corinne, Firtion, Ghislaine, Hau, Isabelle, Chace, Anne, Bolot, Pascal, Blanche, Stéphane, Levine, Martine, Kremlin Bicëtre, Le, Fourcade, Corinne, Heller-Roussin, Brigitte, Runel-Belliard, Camille, Tricoire, Joëlle, Chirouze, Catherine, Reliquet, Véronique, Brouard, Jacque, Kebaili, Kamila, Fialaire, Pascale, Lalande, Muriel, Schultze-Strasser, Stephan, Baumann, U, Niehues, T, Neubert, J, Kobbe, R, Berlin, Charite, Feiterna-Sperling, C, Königs, C, Buchholz, B, Notheis, G, de Martino, Maurizio, Angelo Tovo, Pier, Patrizia, Osimani, Larovere, Domenico, Ruggeri, Maurizio, Faldella, Giacomo, Baldi, Francesco, Badolato, Raffaele, Montagnani, Carlotta, Venturini, Elisabetta, Lisi, Catiuscia, Di Biagio, Antonio, Taramasso, Lucia, Giacomet, Vania, Erba, Paola, Esposito, Susanna, Lipreri, Rita, Salvini, Filippo, Tagliabue, Claudia, Cellini, Monica, Bruzzese, Eugenia, LO VECCHIO, Andrea, Paediatric Infectious Diseases / Rheumatology / Immunology, Amsterdam institute for Infection and Immunity, AII - Infectious diseases, Amsterdam Reproduction & Development (AR&D), APH - Aging & Later Life, Infectious diseases, and Global Health

Subjects
0301 basic medicine, medicine.medical_treatment, lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], HIV Infections, Rate ratio, Cohort Studies, 0302 clinical medicine, Pregnancy, Antiretroviral Therapy, Highly Active, Prevalence, 030212 general & internal medicine, Child, poor immune response, ddc:618, Immunosuppression, Viral Load, Hepatitis B, Thailand, 3. Good health, Europe, Thailand/epidemiology, Infectious Diseases, Cohort, Coinfection, Female, Cohort study, Adult, Microbiology (medical), viral suppression, medicine.medical_specialty, Adolescent, Anti-HIV Agents, antiretroviral therapy, 030106 microbiology, Europe/epidemiology, 03 medical and health sciences, children, Acquired immunodeficiency syndrome (AIDS), SDG 3 - Good Health and Well-being, Internal medicine, medicine, Humans, HIV, Aged, Settore MED/38 - Pediatria Generale e Specialistica, business.industry, Immunity, medicine.disease, HIV Infections/drug therapy/epidemiology, CD4 Lymphocyte Count, lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4], Anti-HIV Agents/therapeutic use, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

Background In human immunodeficiency virus (HIV)–positive adults, low CD4 cell counts despite fully suppressed HIV-1 RNA on antiretroviral therapy (ART) have been associated with increased risk of morbidity and mortality. We assessed the prevalence and outcomes of poor immune response (PIR) in children receiving suppressive ART. Methods Sixteen cohorts from the European Pregnancy and Paediatric HIV Cohort Collaboration (EPPICC) contributed data. Children Results Of 2318 children included, median age was 6.4 years and 68% had advanced/severe immunosuppression at ART initiation. At 1 year of VS, 12% had PIR. In multivariable analysis, PIR was associated with older age and worse immunological stage at ART start, hepatitis B coinfection, and residing in Thailand (all P ≤ .03). Rates of AIDS/death (95% confidence interval) per 100 000 person-years were 1052 (547, 2022) among PIR versus 261 (166, 409) among immune responders; rate ratio of 4.04 (1.83, 8.92; P < .001). Conclusions One in eight children in our cohort experienced PIR despite sustained VS. While the overall rate of AIDS/death was low, children with PIR had a 4-fold increase in risk of event as compared with immune responders.

Published
2020
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50. Global Time-Renormalization of the Gravitational $N$-body Problem

Author

Ander Murua, Philippe Chartier, Joseba Makazaga, Mikel Antoñana, University of the Basque Country [Bizkaia] (UPV/EHU), Institut de Recherche Mathématique de Rennes (IRMAR), AGROCAMPUS OUEST, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-École normale supérieure - Rennes (ENS Rennes)-Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA), MTM2016-77660-P, Ministerio de Economía y Competitividad, IT1294-19, Department of Education of the Basque Government, University of the Basque Country/Euskal Herriko Unibertsitatea (UPV/EHU), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École normale supérieure - Rennes (ENS Rennes)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-INSTITUT AGRO Agrocampus Ouest, and Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)

Subjects
Work (thermodynamics), [MATH.MATH-DS]Mathematics [math]/Dynamical Systems [math.DS], FOS: Physical sciences, Dynamical Systems (math.DS), 010103 numerical & computational mathematics, 01 natural sciences, Gravitational n-body problems, Gravitation, Renormalization, Theoretical physics, 0103 physical sciences, FOS: Mathematics, Mathematics - Dynamical Systems, 0101 mathematics, Blow-up transformation, 010303 astronomy & astrophysics, ComputingMilieux_MISCELLANEOUS, Earth and Planetary Astrophysics (astro-ph.EP), Physics, n-body problem, Global power series representation, Time-renormalization, Numerical integration, Modeling and Simulation, Analysis, Astrophysics - Earth and Planetary Astrophysics, Global time
Abstract

This work considers the {\em gravitational} $N$-body problem and introduces global time-renormalization {\em functions} that allow the efficient numerical integration with fixed time-steps. First, a lower bound of the radius of convergence of the solution to the original equations is derived, which suggests an appropriate time-renormalization. In the new fictitious time $\tau$, it is then proved that any solution exists for all $\tau \in \mathbb{R}$, and that it is uniquely extended as a holomorphic function to a strip of fixed width. As a by-product, a global power series representation of the solutions of the $N$-body problem is obtained. Noteworthy, our global time-renormalizations remain valid in the limit when one of the masses vanishes. Finally, numerical experiments show the efficiency of the new time-renormalization functions for some $N$-body problems with close encounters., Comment: 26 pages; acknowledgments added; remarks 5 and 7 added in second version; remark 4 added and a few minor changes made in third version

Published
2020
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