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20,278 results on '"University of Southampton [Southampton]"'

1. Effect of Oestrogen on Musculoskeletal Outcomes (E2)

Author: University of East Anglia, Norwich, United Kingdom, Osteolabs, Kiel, Germany, University of Salford, Salford, United Kingdom, University of Southampton, Southampton, United Kingdom, and Dr. Thomas O'Leary, Higher Scientific Officer
Published: 2023

2. Cross-Correlation Effects Involving Curie Spin Relaxation in Methyl Groups

Author: Madhu, P.K., Mandal, Pravat K., and Müller, Norbert
Published: 2002
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3. HERAFitter

Author: Alekhin, S.Deutsches Elektronen-Synchrotron (DESY), Platanenallee 6, 15738, Zeuthen, Germany, Behnke, O.(Deutsches Elektronen-Synchrotron (DESY), Hamburg, Germany), Belov, P.(Deutsches Elektronen-Synchrotron (DESY), Hamburg, Germany), Borroni, S.(Deutsches Elektronen-Synchrotron (DESY), Hamburg, Germany), Botje, M.(Nikhef, Science Park, Amsterdam, The Netherlands), Britzger, D.(Deutsches Elektronen-Synchrotron (DESY), Hamburg, Germany), Camarda, S.(Deutsches Elektronen-Synchrotron (DESY), Hamburg, Germany), Cooper-Sarkar, A. M.(Department of Physics, University of Oxford, Oxford, UK), Daum, K.(Fachbereich C, Universität Wuppertal, Wuppertal, Germany), Diaconu, C.(Aix Marseille Universite, CNRS/IN2P3, CPPM UMR 7346, 13288, Marseille, France), Feltesse, J.(CEA, DSM/Irfu, CE-Saclay, Gif-sur-Yvette, France), Gizhko, A.(Deutsches Elektronen-Synchrotron (DESY), Hamburg, Germany), Glazov, A.(Deutsches Elektronen-Synchrotron (DESY), Hamburg, Germany), Guffanti, A.(Niels Bohr International Academy and Discovery Center, Niels Bohr Institute, University of Copenhagen, Blegdamsvej 17, 2100, Copenhagen, Denmark), Guzzi, M.(Deutsches Elektronen-Synchrotron (DESY), Hamburg, Germany), Hautmann, F.(School of Physics and Astronomy, University of Southampton, Southampton, UK), Jung, A.(FERMILAB, 60510, Batavia, IL, USA), Jung, H.(Deutsches Elektronen-Synchrotron (DESY), Hamburg, Germany), Kolesnikov, V.(Joint Institute for Nuclear Research (JINR), Joliot-Curie 6, 141980, Dubna, Moscow Region, Russia), Kowalski, H.(Deutsches Elektronen-Synchrotron (DESY), Hamburg, Germany), Kuprash, O.(Deutsches Elektronen-Synchrotron (DESY), Hamburg, Germany), Kusina, A.(Southern Methodist University, Dallas, TX, USA), Levonian, S.(Deutsches Elektronen-Synchrotron (DESY), Hamburg, Germany), Lipka, K.(Deutsches Elektronen-Synchrotron (DESY), Hamburg, Germany), Lobodzinski, B.(Max Planck Institut für Physik, Werner Heisenberg Institut, Föhringer Ring 6, München, Germany), Lohwasser, K.(Deutsches Elektronen-Synchrotron (DESY), Platanenallee 6, 15738, Zeuthen, Germany), Luszczak, A.(T. Kosciuszko University of Technology, Kraków, Poland), Malaescu, B.(Laboratoire de Physique Nucléaire et de Hautes Energies, UPMC and Université, Paris-Diderot and CNRS/IN2P3, Paris, France), McNulty, R.(University College Dublin, Dublin 4, Ireland), Myronenko, V.(Deutsches Elektronen-Synchrotron (DESY), Hamburg, Germany), Naumann-Emme, S.(Deutsches Elektronen-Synchrotron (DESY), Hamburg, Germany), Nowak, K.(Deutsches Elektronen-Synchrotron (DESY), Hamburg, Germany), Olness, F.(Southern Methodist University, Dallas, TX, USA), Perez, E.(CERN, European Organization for Nuclear Research, Geneva, Switzerland), Pirumov, H.(Deutsches Elektronen-Synchrotron (DESY), Hamburg, Germany), Plačakytė, R.(Deutsches Elektronen-Synchrotron (DESY), Hamburg, Germany), Rabbertz, K.(Institut für Experimentelle Kernphysik, Karlsruhe, Germany), Radescu, V.(Deutsches Elektronen-Synchrotron (DESY), Hamburg, Germany), Sadykov, R.(Joint Institute for Nuclear Research (JINR), Joliot-Curie 6, 141980, Dubna, Moscow Region, Russia), Salam, G. P.(CERN, PH-TH, 1211, Geneva 23, Switzerland), Sapronov, A.(Joint Institute for Nuclear Research (JINR), Joliot-Curie 6, 141980, Dubna, Moscow Region, Russia), Schöning, A.(Physikalisches Institut, Universität Heidelberg, Heidelberg, Germany), Schörner-Sadenius, T.(Deutsches Elektronen-Synchrotron (DESY), Hamburg, Germany), Shushkevich, S.(Deutsches Elektronen-Synchrotron (DESY), Hamburg, Germany), Slominski, W.(Institute of Physics, Jagiellonian University, Reymonta 4, 30-059, Kraków, Poland), Spiesberger, H.(PRISMA Cluster of Excellence, Institut für Physik (WA THEP), Johannes-Gutenberg-Universität, 55099, Mainz, Germany), Starovoitov, P.(Deutsches Elektronen-Synchrotron (DESY), Hamburg, Germany), Sutton, M.(Department of Physics and Astronomy, University of Sussex, Sussex House, BN1 9RH, Brighton, UK), Tomaszewska, J.(Faculty of Physics, Warsaw University of Technology, Koszykowa 75, 00-662, Warsaw, Poland), Turkot, O.(Deutsches Elektronen-Synchrotron (DESY), Hamburg, Germany), Vargas, A.(Deutsches Elektronen-Synchrotron (DESY), Hamburg, Germany), Watt, G.(Institute for Particle Physics Phenomenology, Durham University, DH1 3LE, Durham, UK), and Wichmann, K.(Deutsches Elektronen-Synchrotron (DESY), Hamburg, Germany)
Subjects: Physics and Astronomy (miscellaneous), Physics, High Energy Physics::Experiment, Nuclear Experiment, Engineering (miscellaneous), QC
Abstract: HERAFitter is an open-source package that provides a framework for the determination of the parton distribution functions (PDFs) of the proton and for many different kinds of analyses in Quantum Chromodynamics (QCD). It encodes results from a wide range of experimental measurements in lepton-proton deep inelastic scattering and proton-proton (proton-antiproton) collisions at hadron colliders. These are complemented with a variety of theoretical options for calculating PDF-dependent cross section predictions corresponding to the measurements. The framework covers a large number of the existing methods and schemes used for PDF determination. The data and theoretical predictions are brought together through numerous methodological options for carrying out PDF fits and plotting tools to help to visualise the results. While primarily based on the approach of collinear factorisation, HERAFitter also provides facilities for fits of dipole models and transverse-momentum dependent PDFs. The package can be used to study the impact of new precise measurements from hadron colliders. This paper describes the general structure of HERAFitter and its wide choice of options.
Published: 2015

4. EXACT ELASTIC STABILITY ANALYSIS BASED ON DYNAMIC STIFFNESS METHOD

Author: Iakovliev, Andrii; University of Southampton, Southampton, United Kingdom and Iakovliev, Andrii; University of Southampton, Southampton, United Kingdom
Abstract: The article is dedicated to the discussion on the exact dynamic stiffness matrix method applied to the problems of elastic stability of engineering structures. The detailed formulation of the member dynamic stiffness matrix for beams is presented along with the general guidelines on automatisation of the assembly of member dynamic stiffness matrices into the global matrix that corresponds to the whole structure. The advantage of the dynamic stiffness matrix in case of parametric studies is explained. The problem of computing the eigenvalues of transcendental matrix is addressed. The straightforward approach as well as a powerful Witrick-Williams algorithm are discussed in details. The general guidelines on programming the DS matrix method are given as well., Статья посвящена обсуждению применения точного метода динамической матрицы жесткости к проблемам упругой устойчивости инженерных конструкций. В статье представлен вывод динамической матрицы жесткости для структурных балочных компонентов с последующим руководством к автоматизации сборки глобальной динамической матрицы жесткости для всей конструкции из матриц для каждого компонента. Также обсуждаются преимущества метода динамической матрицы жесткости в случае параметрических расчетов. Проанализирована проблема расчета собственных значений трансцендентной матрицы жесткости. В деталях анализируются как метод прямого расчета собственных значений, так и мощный алгоритм Виттрика-Вильямса. В статье также приводится общее руководство к программированию метода динамической матрицы жесткости.
Published: 2016

5. Pseudomonas aeruginosa: A model for biofilm formation

Author: Rhem, B., McDougald, Diane, Centre for Marine Biofouling & Bioinnovation, UNSW, Klebensberger, Janosch, Centre for Marine Biofouling & Bioinnovation, UNSW, Tolker-Nielsen, Tim, Centre for Biomedical Microbiology, BioCentrum-DTU, Technical University of Denmark, Lyngby, Denmark, Webb, Jeremy S., School of Biological Sciences, University of Southampton, Southampton, UK, Conibear, Tim, School of Biological Sciences, University of Southampton, Southampton, UK, Rice, Scott A., Centre for Marine Biofouling & Bioinnovation, UNSW, Kirov, Sylvia M., School of Medicine (Pathology), University of Tasmania, Hobart, Australia, Matz, Carsten, GBF - National Research Centre for Biotechnology, Center for Biomedical Microbiology, Kjelleberg, Staffan, Centre for Marine Biofouling & Bioinnovation, UNSW, Rhem, B., McDougald, Diane, Centre for Marine Biofouling & Bioinnovation, UNSW, Klebensberger, Janosch, Centre for Marine Biofouling & Bioinnovation, UNSW, Tolker-Nielsen, Tim, Centre for Biomedical Microbiology, BioCentrum-DTU, Technical University of Denmark, Lyngby, Denmark, Webb, Jeremy S., School of Biological Sciences, University of Southampton, Southampton, UK, Conibear, Tim, School of Biological Sciences, University of Southampton, Southampton, UK, Rice, Scott A., Centre for Marine Biofouling & Bioinnovation, UNSW, Kirov, Sylvia M., School of Medicine (Pathology), University of Tasmania, Hobart, Australia, Matz, Carsten, GBF - National Research Centre for Biotechnology, Center for Biomedical Microbiology, and Kjelleberg, Staffan, Centre for Marine Biofouling & Bioinnovation, UNSW
Abstract: Much of the fundamental understanding of microbial physiology is based onlaboratory studies of freely suspended cells. While these studies have been essentialfor our foundational understanding of the genetics, physiology and behavior ofmicrobes, it is now recognized that a majority of bacterial cells in nature exist inbiofilms [1] associated with surfaces or as floating cell aggregates. In fact, it hasrecently been proposed that microbial communities originally developed on surfaces,including the first bacterial and archael cells, and that the planktonic cell phenotypeevolved as a dispersal mechanism [2]. Hallmarks of cells residing in biofilmcommunities are increased metabolic efficiency [3] as well as increased resistanceto environmental stresses such as desiccation, ultraviolet radiation and oxidativestress [4–6]. This correlation has dramatic consequences as residing in aggregateshas been shown to confer increased resistance of bacterial cells also to biocides suchas antibiotics, disinfectants and detergents [7–9]. In addition, once established, thesebiofilms are able to resist invasion by other organisms and predation by protozoans innature or host immune cells in the human body [5,6,10]. This is especially problematicas it is also recognized that the majority of bacterial infections involve biofilms[11]. The recent explosion of research in the field of biofilm biology has led to anenhanced appreciation for the multicellular aspects of microbiology and has resultedin the general acceptance of a model of the biofilm mode of life.Pseudomonas aeruginosa has become a model organism for the study of biofilmsdue to its metabolic versatility and variability in its response to environmental signals,which promotes successful colonization of different habitats and growth undervarying environmental conditions [12,13]. This ability is likely a reflection of its largegenome, allowing for metabolic plasticity and quick responses to varying stimuli.P. aeruginosa is also a hum
Published: 2008

6. The t(1;9)(p34;q34) fusing ABL1 with SFPQ, a pre-mRNA processing gene, is recurrent in acute lymphoblastic leukemias.

Author: UCL - SSS/IREC - Institut de recherche expérimentale et clinique, Institut Gustave Roussy, Villejuif, France - Laboratoire de Cytogénétique, Centre Hospitalier de Luxembourg, Luxembourg, Luxembourg - Service d’Hémato-Cancérologie, Institut Gustave Roussy, Villejuif, France - Service d’Hématologie, University of Southampton, Southampton, United Kingdom - Wessex Regional Genetics Laboratory, Salisbury District Hospital and Human Genetics Division, UCL - SSS/DDUV - Institut de Duve, UCL - (SLuc) Centre de génétique médicale UCL, Duhoux, François, Auger, Nathalie, De Wilde, Sigrid, Wittnebel, Sebastian, Ameye, Geneviève, Bahloula, Khadija, Van den Berg, Catherine, Libouton, Jeanne-Marie, Saussoy, Pascale, Grand, Francis H, Demoulin, Jean-Baptiste, Poirel, Hélène, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, Institut Gustave Roussy, Villejuif, France - Laboratoire de Cytogénétique, Centre Hospitalier de Luxembourg, Luxembourg, Luxembourg - Service d’Hémato-Cancérologie, Institut Gustave Roussy, Villejuif, France - Service d’Hématologie, University of Southampton, Southampton, United Kingdom - Wessex Regional Genetics Laboratory, Salisbury District Hospital and Human Genetics Division, UCL - SSS/DDUV - Institut de Duve, UCL - (SLuc) Centre de génétique médicale UCL, Duhoux, François, Auger, Nathalie, De Wilde, Sigrid, Wittnebel, Sebastian, Ameye, Geneviève, Bahloula, Khadija, Van den Berg, Catherine, Libouton, Jeanne-Marie, Saussoy, Pascale, Grand, Francis H, Demoulin, Jean-Baptiste, and Poirel, Hélène
Published: 2011

7. Differential suppression of tumor-specific CD8+ T Cells by regulatory T cells

Author: University of Southampton, Southampton, UK - Cancer Sciences Division, School of Medicine, Hannover Medical School, Hannover, Germany - Department of Gastroenterology, Hepatology, and Endocrinology, UCL - SSS/DDUV - Institut de Duve, James, Edward, Yeh, Alex, King, Cathy, Korangy, Firouzeh, Bailey, Ian, Boulanger, Denise S., Van den Eynde, Benoît, Murray, Nicholas, Elliott, Tim J., University of Southampton, Southampton, UK - Cancer Sciences Division, School of Medicine, Hannover Medical School, Hannover, Germany - Department of Gastroenterology, Hepatology, and Endocrinology, UCL - SSS/DDUV - Institut de Duve, James, Edward, Yeh, Alex, King, Cathy, Korangy, Firouzeh, Bailey, Ian, Boulanger, Denise S., Van den Eynde, Benoît, Murray, Nicholas, and Elliott, Tim J.
Abstract: In the CT26 BALB/c murine model of colorectal carcinoma, depletion of regulatory T cells (Tregs) prior to tumor inoculation results in protective immunity to both CT26 and other BALB/c-derived tumors of diverse histological origin. In this paper, we show that cross-protection can be conferred by adoptively transferred CD8(+) CTLs. Other schedules for inducing immunity to CT26 have been described, but they do not lead to cross-protection. We show that Treg ablation facilitates the development of new CTL specificities that are normally cryptic, and have mapped the root epitope of one of these responses. This work has allowed us to demonstrate how the specificity of CTL responses to tumor Ags can be controlled via differential suppression of CTL specificities by Tregs, and how this can result in very different physiological outcomes.
Published: 2010

8. Supersymmetry parameter analysis: SPA convention and project

Author: MCTP, University of Michigan, Ann Arbor, MI, USA, Department of Modern Physics, University of Science and Technology of China, Hefei, China, William I. Fine Theoretical Physics Institute, University of Minnesota, Minneapolis, MN, USA, Laboratoire de Physique des Particules, Annecy-le-Vieux, France, Laboratoire de Physique Subatomique et de Cosmologie, Universit?? Grenoble I, Grenoble, France, Department of Physics, Tohoku University, Sendai, Japan, IPPP, University of Durham, Durham, UK, Department of Physics and Astronomy, Johns Hopkins University, Baltimore, MD, USA, PH Department, CERN, Geneva, Switzerland, Department of Physics, Texas A&M University, College Station, TX, USA, Institut f??r Hochenergiephysik, ??sterreichische Akademie der Wissenschaften, Wien, Austria, Institut f??r Experimentalphysik, Universit??t Hamburg, Hamburg, Germany, Max-Planck-Institut f??r Physik, M??nchen, Germany, Department of Mathematical Sciences, University of Liverpool, Liverpool, UK, Deutsches Elektronen-Synchrotron DESY, Hamburg, Germany, Institute of Theoretical Physics, Warsaw University, Warsaw, Poland, Laboratoire de Physique Theorique, Annecy-le-Vieux, France, Physikalisches Institut, Universit??t Freiburg, Freiburg, Germany, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China, Department of Physics and Astronomy, University of Rochester, Rochester, NY, USA, Lawrence Berkeley National Laboratory, Berkeley, CA, USA, School of Physics and Astronomy, University of Southampton, Southampton, UK, Department of Physics and Astronomy, Michigan State University, East Lansing, MI, USA, LPTA, Universit?? Montpellier II, CNRS-IN2P3, Montpellier, France, High Energy Physics Division, Argonne National Laboratory, Argonne, IL, USA, Department of Physics and Astronomy, University of Sheffield, Sheffield, UK, Harish-Chandra Research Institute, Allahabad, India, University of Colorado, Boulder, CO, USA, IPN Universit?? Lyon, IN2P3-CNRS, Lyon, France, Theory Division, KEK, Tsukuba, Japan, Center for High Energy Physics and Institute of Modern Physics, Tsinghua University, Beijing, China, Santa Cruz Institute for Particle Physics, University of California, Santa Cruz, CA, USA, Fermi National Accelerator Laboratory, Batavia, IL, USA, Departamento de Fisica and CFTP, Instituto Superior Tecnico, Lisbon, Portugal, Department of Physics and Astronomy, University of Glasgow, Glasgow, UK, Deutsches Elektronen-Synchrotron DESY, Zeuthen, Germany, Department of Physics, National Taiwan University, Taipei, Taiwan, Paul Scherrer Institut, Villigen, Switzerland, Institut f??r Theoretische Physik, Universit??t Z??rich, Z??rich, Switzerland, LAL, Universit?? de Paris-Sud, IN2P3-CNRS, Orsay, France, Stanford Linear Accelerator Center, Stanford, CA, USA; University of Delhi, Delhi, India, Institut f??r Theoretische Physik und Astrophysik, Universit??t W??rzburg, W??rzburg, Germany, Instituto de F??sica, UNAM, M??xico, Mexico, School of Physics, Seoul National University, Seoul, Korea, Stanford Linear Accelerator Center, Stanford, CA, USA; PH Department, CERN, Geneva, Switzerland, Tata Institute of Fundamental Research, Mumbai, India, Department of Physics, University of Wisconsin, Madison, WI, USA, Instituto de F??sica Corpuscular, CSIC, Val??ncia, Spain, Department of Physics, Florida State University, Tallahassee, FL, USA, Department of Theoretical Physics, Aristotle University of Thessaloniki, Thessaloniki, Greece, Centre for High Energy Physics, Indian Institute of Science, Bangalore, India, Institut f??r Theoretische Physik, RWTH Aachen, Aachen, Germany, Facultat de F??sica, Universitat de Barcelona, Barcelona, Spain, Department of Physics, Yonsei University, Seoul, Korea, Physikalisches Institut der Universit??t Bonn, Bonn, Germany, Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA, USA, Department of Physics, Chung-Ang University, Seoul, Korea, Department of Physics, Carleton University, Ottawa, ON, Canada, Institut f??r Theoretische Physik, Universit??t Wien, Wien, Austria, Institut f??r Theoretische Physik, Universit??t Z??rich, Z??rich, Switzerland; Instituto de F??sica Corpuscular, CSIC, Val??ncia, Spain, Department of Physics, University of Florida, Gainesville, FL, USA, Royal Holloway University of London, Egham, Surrey, UK, Department of Physics, Chonbuk National University, Chonju, Korea, Skobeltsyn Institute of Nuclear Physics, MSU, Moscow, Russia, Institute of Theoretical Physics, University of Tokushima, Tokushima, Japan, Deutsches Elektronen-Synchrotron DESY, Hamburg, Germany; I. Physikalisches Institut der RWTH Aachen, Aachen, Germany, High Energy Physics, Uppsala University, Uppsala, Sweden, ICEPP, University of Tokyo, Tokyo, Japan, YITP, Kyoto Universty, Kyoto, Japan, ITP, School of Physics, Peking University, Beijing, China, Department of Physics, University of California, Davis, CA, USA, Department of Physics, Tokyo Gakugei University, Tokyo, Japan, DAMTP, University of Cambridge, Cambridge, UK, Physics Department, Universidad Catolica de Chile, Santiago, Chile, Stanford Linear Accelerator Center, Stanford, CA, USA, INFN, Sezione di Pavia, Pavia, Italy, High Energy Physics Division, Argonne National Laboratory, Argonne, IL, USA; Enrico Fermi Institute, University of Chicago, Chicago, IL, USA, Ann Arbor, Allanach, B. C., King, S. F., Blair, G. A., Kraml, S., Kim, C. S., Bagger, J. A., Barnett, M., Ellis, J., Hou, Wei-Shu, Roy, P., Yamada, Y., Xing, Z. -Z., Hurth, T., Jiang, Y., Zerwas, P. M., Belyaev, A., Reuter, J., Langacker, Paul, Valle, J. W. F., M??hlleitner, M. M., Spira, M., Nojiri, M. M., Majerotto, W., Moortgat-Pick, G., Moretti, S., Hesselbach, S., He, H. -J., Haber, H. E., Hagiwara, K., Boos, E., Carena, M., Aguilar-Saavedra, J. A., Miller, D. J., Nowak, H., Nomura, D., Okada, N., Lafaye, R., Erler, J., Wienemann, P., Polesello, G., Jones, D. R. T., Fritzsche, T., Zerwas, D., B??langer, G., Bartl, A., Richardson, P., Rolbiecki, K., Schleper, P., Kilian, W., Rzehak, H., Kang, S. K., Yang, J. M., Bechtle, P., Freitas, A., Kane, Gordon L., Fraas, H., Kalinowski, J., Kamon, T., Jack, I., Eberl, H., Dutta, B., Dutta, S., Barger, V., Wagner, C. E. M., Ma, W. -G., Rainwater, D., Berger, E. L., Desch, K., Gounaris, G. J., Godbole, R. M., Guasch, J., Olive, K. A., Kittel, O., Klasen, M., Kr??mer, M., Logan, H. E., Zhang, R. -Y., Skands, P., Weiglein, G., Slavich, P., Zhang, X., Deppisch, F., Ali, Aejaz., Choi, S. Y., Han, T., Haba, N., Roeck, Albert De, Matchev, Konstantin T., Han, L., Heinemeyer, S., Martyn, H. -U., Moultaka, G., Mondragon, M., Sphicas, P., Mori, T., Mukhopadhyaya, B., Muanza, S., St??ckinger, D., Nauenberg, U., Tait, T., Tovey, D. R., Siyeon, K., Hidaka, K., Gunion, J., R??ckl, R., Weber, Ch., Hirsch, M., Hinchliffe, I., Djouadi, A., Peskin, M., Plehn, T., Arnowitt, R., Diaz, M. A., Baer, H. A., Porod, W., Balazs, C., Quevedo, F., Hohenwarter-Sodek, K., Kernreiter, T., Zhu, S. -H., Battaglia, Marco, ??ller, W., Hollik, W., Kovarik, K., Kneur, J. -L., MCTP, University of Michigan, Ann Arbor, MI, USA, Department of Modern Physics, University of Science and Technology of China, Hefei, China, William I. Fine Theoretical Physics Institute, University of Minnesota, Minneapolis, MN, USA, Laboratoire de Physique des Particules, Annecy-le-Vieux, France, Laboratoire de Physique Subatomique et de Cosmologie, Universit?? Grenoble I, Grenoble, France, Department of Physics, Tohoku University, Sendai, Japan, IPPP, University of Durham, Durham, UK, Department of Physics and Astronomy, Johns Hopkins University, Baltimore, MD, USA, PH Department, CERN, Geneva, Switzerland, Department of Physics, Texas A&M University, College Station, TX, USA, Institut f??r Hochenergiephysik, ??sterreichische Akademie der Wissenschaften, Wien, Austria, Institut f??r Experimentalphysik, Universit??t Hamburg, Hamburg, Germany, Max-Planck-Institut f??r Physik, M??nchen, Germany, Department of Mathematical Sciences, University of Liverpool, Liverpool, UK, Deutsches Elektronen-Synchrotron DESY, Hamburg, Germany, Institute of Theoretical Physics, Warsaw University, Warsaw, Poland, Laboratoire de Physique Theorique, Annecy-le-Vieux, France, Physikalisches Institut, Universit??t Freiburg, Freiburg, Germany, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China, Department of Physics and Astronomy, University of Rochester, Rochester, NY, USA, Lawrence Berkeley National Laboratory, Berkeley, CA, USA, School of Physics and Astronomy, University of Southampton, Southampton, UK, Department of Physics and Astronomy, Michigan State University, East Lansing, MI, USA, LPTA, Universit?? Montpellier II, CNRS-IN2P3, Montpellier, France, High Energy Physics Division, Argonne National Laboratory, Argonne, IL, USA, Department of Physics and Astronomy, University of Sheffield, Sheffield, UK, Harish-Chandra Research Institute, Allahabad, India, University of Colorado, Boulder, CO, USA, IPN Universit?? Lyon, IN2P3-CNRS, Lyon, France, Theory Division, KEK, Tsukuba, Japan, Center for High Energy Physics and Institute of Modern Physics, Tsinghua University, Beijing, China, Santa Cruz Institute for Particle Physics, University of California, Santa Cruz, CA, USA, Fermi National Accelerator Laboratory, Batavia, IL, USA, Departamento de Fisica and CFTP, Instituto Superior Tecnico, Lisbon, Portugal, Department of Physics and Astronomy, University of Glasgow, Glasgow, UK, Deutsches Elektronen-Synchrotron DESY, Zeuthen, Germany, Department of Physics, National Taiwan University, Taipei, Taiwan, Paul Scherrer Institut, Villigen, Switzerland, Institut f??r Theoretische Physik, Universit??t Z??rich, Z??rich, Switzerland, LAL, Universit?? de Paris-Sud, IN2P3-CNRS, Orsay, France, Stanford Linear Accelerator Center, Stanford, CA, USA; University of Delhi, Delhi, India, Institut f??r Theoretische Physik und Astrophysik, Universit??t W??rzburg, W??rzburg, Germany, Instituto de F??sica, UNAM, M??xico, Mexico, School of Physics, Seoul National University, Seoul, Korea, Stanford Linear Accelerator Center, Stanford, CA, USA; PH Department, CERN, Geneva, Switzerland, Tata Institute of Fundamental Research, Mumbai, India, Department of Physics, University of Wisconsin, Madison, WI, USA, Instituto de F??sica Corpuscular, CSIC, Val??ncia, Spain, Department of Physics, Florida State University, Tallahassee, FL, USA, Department of Theoretical Physics, Aristotle University of Thessaloniki, Thessaloniki, Greece, Centre for High Energy Physics, Indian Institute of Science, Bangalore, India, Institut f??r Theoretische Physik, RWTH Aachen, Aachen, Germany, Facultat de F??sica, Universitat de Barcelona, Barcelona, Spain, Department of Physics, Yonsei University, Seoul, Korea, Physikalisches Institut der Universit??t Bonn, Bonn, Germany, Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA, USA, Department of Physics, Chung-Ang University, Seoul, Korea, Department of Physics, Carleton University, Ottawa, ON, Canada, Institut f??r Theoretische Physik, Universit??t Wien, Wien, Austria, Institut f??r Theoretische Physik, Universit??t Z??rich, Z??rich, Switzerland; Instituto de F??sica Corpuscular, CSIC, Val??ncia, Spain, Department of Physics, University of Florida, Gainesville, FL, USA, Royal Holloway University of London, Egham, Surrey, UK, Department of Physics, Chonbuk National University, Chonju, Korea, Skobeltsyn Institute of Nuclear Physics, MSU, Moscow, Russia, Institute of Theoretical Physics, University of Tokushima, Tokushima, Japan, Deutsches Elektronen-Synchrotron DESY, Hamburg, Germany; I. Physikalisches Institut der RWTH Aachen, Aachen, Germany, High Energy Physics, Uppsala University, Uppsala, Sweden, ICEPP, University of Tokyo, Tokyo, Japan, YITP, Kyoto Universty, Kyoto, Japan, ITP, School of Physics, Peking University, Beijing, China, Department of Physics, University of California, Davis, CA, USA, Department of Physics, Tokyo Gakugei University, Tokyo, Japan, DAMTP, University of Cambridge, Cambridge, UK, Physics Department, Universidad Catolica de Chile, Santiago, Chile, Stanford Linear Accelerator Center, Stanford, CA, USA, INFN, Sezione di Pavia, Pavia, Italy, High Energy Physics Division, Argonne National Laboratory, Argonne, IL, USA; Enrico Fermi Institute, University of Chicago, Chicago, IL, USA, Ann Arbor, Allanach, B. C., King, S. F., Blair, G. A., Kraml, S., Kim, C. S., Bagger, J. A., Barnett, M., Ellis, J., Hou, Wei-Shu, Roy, P., Yamada, Y., Xing, Z. -Z., Hurth, T., Jiang, Y., Zerwas, P. M., Belyaev, A., Reuter, J., Langacker, Paul, Valle, J. W. F., M??hlleitner, M. M., Spira, M., Nojiri, M. M., Majerotto, W., Moortgat-Pick, G., Moretti, S., Hesselbach, S., He, H. -J., Haber, H. E., Hagiwara, K., Boos, E., Carena, M., Aguilar-Saavedra, J. A., Miller, D. J., Nowak, H., Nomura, D., Okada, N., Lafaye, R., Erler, J., Wienemann, P., Polesello, G., Jones, D. R. T., Fritzsche, T., Zerwas, D., B??langer, G., Bartl, A., Richardson, P., Rolbiecki, K., Schleper, P., Kilian, W., Rzehak, H., Kang, S. K., Yang, J. M., Bechtle, P., Freitas, A., Kane, Gordon L., Fraas, H., Kalinowski, J., Kamon, T., Jack, I., Eberl, H., Dutta, B., Dutta, S., Barger, V., Wagner, C. E. M., Ma, W. -G., Rainwater, D., Berger, E. L., Desch, K., Gounaris, G. J., Godbole, R. M., Guasch, J., Olive, K. A., Kittel, O., Klasen, M., Kr??mer, M., Logan, H. E., Zhang, R. -Y., Skands, P., Weiglein, G., Slavich, P., Zhang, X., Deppisch, F., Ali, Aejaz., Choi, S. Y., Han, T., Haba, N., Roeck, Albert De, Matchev, Konstantin T., Han, L., Heinemeyer, S., Martyn, H. -U., Moultaka, G., Mondragon, M., Sphicas, P., Mori, T., Mukhopadhyaya, B., Muanza, S., St??ckinger, D., Nauenberg, U., Tait, T., Tovey, D. R., Siyeon, K., Hidaka, K., Gunion, J., R??ckl, R., Weber, Ch., Hirsch, M., Hinchliffe, I., Djouadi, A., Peskin, M., Plehn, T., Arnowitt, R., Diaz, M. A., Baer, H. A., Porod, W., Balazs, C., Quevedo, F., Hohenwarter-Sodek, K., Kernreiter, T., Zhu, S. -H., Battaglia, Marco, ??ller, W., Hollik, W., Kovarik, K., and Kneur, J. -L.
Abstract: High-precision analyses of supersymmetry parameters aim at reconstructing the fundamental supersymmetric theory and its breaking mechanism. A well defined theoretical framework is needed when higher-order corrections are included. We propose such a scheme, Supersymmetry Parameter Analysis SPA, based on a consistent set of conventions and input parameters. A repository for computer programs is provided which connect parameters in different schemes and relate the Lagrangian parameters to physical observables at LHC and high energy e + e - linear collider experiments, i.e., masses, mixings, decay widths and production cross sections for supersymmetric particles. In addition, programs for calculating high-precision low energy observables, the density of cold dark matter (CDM) in the universe as well as the cross sections for CDM search experiments are included. The SPA scheme still requires extended efforts on both the theoretical and experimental side before data can be evaluated in the future at the level of the desired precision. We take here an initial step of testing the SPA scheme by applying the techniques involved to a specific supersymmetry reference point.
Published: 2006

9. Response to Guttman & Levy's article???on the definition and varieties of attitude and wellbeing???

Author: University of Michigan, Ann Arbor, USA; University of Southampton, Southampton, UK, Ann Arbor, McKennell, Aubrey C., Andrews, Frank M., University of Michigan, Ann Arbor, USA; University of Southampton, Southampton, UK, Ann Arbor, McKennell, Aubrey C., and Andrews, Frank M.
Abstract: Guttman and Levy have prepared an extravagant critique focused mainly on the 1980 Andrews-McKennell article in this journal. The clearly stated purpose of that article was to report a???series of explorations into the affective and cognitive components of some of the more widely used measures of perceived well-being???. Guttman and Levy ignore this. They proceed on the mistaken impression that we were (or perhaps should have been) embarking upon a definitional exercise to relate the concepts of attitude and wellbeing. Yet the reason we did not cite their article on that topic was precisely because it did not address in a direct or focused way the topic that concerned us. Their critique consists of an entirely irrelevant reanalysis of some attitudinal data by Ostrom, together with a tissue of recondite definitional and methodological issues of little consequence either for the objectives or the conclusions of our research. Their dismissal of our work as???scientific retrogression??? rests on an a priori definition of science that fits their own methodological style but excludes that of many other prominent researchers. Their comments reflect an attempt at methodological imperialism. We defend our independence??? and that of other investigators??? to use promising new methodologies other than the particular approach advocated by Guttman and Levy. (Their denunciation of the new methods of structural equation modeling is not shared even by the authoritative reviewer they themselves quote.) In addition to Guttman and Levy's specific criticisms, our Response addresses general methodological issues such as the status of structural modeling and the testing of structural models. In a concluding section we identify areas that merit further research.
Published: 2006

10. Modelling of composition changes during F-region storms: a reassessment

Author: Space Physics Research Laboratory, University of Michigan, Ann Arbor, MI 48105, U.S.A., Department of Physics and Astronomy, University College London, Gower Street, London WC1E 6BT, U.K., Department of Physics, University of Southampton, Southampton SO9 5NH, U.K., National Center for Atmospheric Research, P.O. Box 3000, Boulder, CO 80307, U.S.A., Fuller-Rowell, T.J., Rees, D., Rishbeth, H., Burns, A.G., Killeen, Timothy L., Roble, Raymond Gerald, Space Physics Research Laboratory, University of Michigan, Ann Arbor, MI 48105, U.S.A., Department of Physics and Astronomy, University College London, Gower Street, London WC1E 6BT, U.K., Department of Physics, University of Southampton, Southampton SO9 5NH, U.K., National Center for Atmospheric Research, P.O. Box 3000, Boulder, CO 80307, U.S.A., Fuller-Rowell, T.J., Rees, D., Rishbeth, H., Burns, A.G., Killeen, Timothy L., and Roble, Raymond Gerald
Abstract: A recalculation of the global changes of thermospheric gas composition, resulting from strong heat inputs in the auroral ovals, shows that (contrary to some previous suggestions) widespread increases of mean molecular mass are produced at mid-latitudes, in summer and at equinox. Decreases of mean molecular mass occur at mid-latitudes in winter. Similar results are given by both the `UCL' and `NCAR TIGCM' three-dimensional models. The computed composition changes now seem consistent with the local time and seasonal response observed by satellites, and can broadly account for `negative storm effects' in the ionospheric F2-layer at mid-latitudes.
Published: 2006

11. Physician's appraisal vs documented signs and symptoms in the interpretation of food challenge tests: The EuroPrevall birth cohort

Author: [ 1 ] Robert Koch Inst, Dept Infect Dis Epidemiol, Berlin, Germany Show more [ 2 ] Charite Univ Med Berlin, Dept Dermatol Venerol & Allergol, Berlin, Germany Show more [ 3 ] German Rheumatism Res Ctr, Berlin, Germany [ 4 ] RTI Int, HTA Hlth Econ Strategy & Res, Manchester, Lancs, England Show more [ 5 ] Univ Groningen, Univ Med Ctr Groningen, Dept Pediat Pulmonol & Pediat Allergol, Groningen, Netherlands Show more [ 6 ] Univ Southampton, Univ Child Hlth, Southampton, Hants, England Show more [ 7 ] Univ Southampton, Clin Expt Sci, Southampton, Hants, England Show more [ 8 ] Paediat Hosp Bambino Gesu, Dept Paediat, Rome, Italy Show more [ 9 ] Univ Athens, Dept Allergy & Clin Immunol, Pediat Clin 2, Athens, Greece Show more [ 10 ] Univ Manchester, Div Infect Immun & Resp Med, Manchester, Lancs, England Show more [ 11 ] Hosp Univ La Paz, Alergia Infantil, Madrid, Spain [ 12 ] Med Univ, Dept Immunol Rheumatol & Allergy, Lodz, Poland [ 13 ] Landspitali, Dept Immunol, Reykjavik, Iceland Show more [ 14 ] Vilnius Univ, Fac Med, Vilnius, Lithuania Show more [ 15 ] Univ Coll, Paediat & Child Hlth, Cork, Ireland Show more [ 16 ] Charite Univ Med Berlin, Dept Paediat Pneumol & Immunol, Berlin, Germany Show more [ 17 ] Charite Univ Med Berlin, Inst Social Med Epidemiol & Hlth Econ, Berlin, Germany, Department for Infectious Disease Epidemiology; Robert Koch Institute; Berlin Germany, German Rheumatism Research Center; Berlin Germany, HTA Health Economics Strategy and Research; RTI International; Manchester UK, Department of Pediatric Pulmonology & Pediatric Allergology; University of Groningen, University Medical Center Groningen; Groningen The Netherlands, University Child Health; University of Southampton; Southampton Hampshire UK, Clinical Experimental Sciences; University of Southampton; Southampton Hampshire UK, Department of Paediatrics; Paediatric Hospital Bambino Gesù; Rome Italy, Department of Allergy and Clinical Immunology; 2nd Pediatric Clinic; National & Kapodistrian University of Athens; Athens Greece, Division of Infection Immunity & Respiratory Medicine; University of Manchester; Manchester UK, Alergia Infantil; Hospital Universitario La Paz; Madrid Spain, Department of Immunology, Rheumatology and Allergy; Medical University; Lodz Poland, Department of Immunology; Landspitali - The National University Hospital of Iceland; Reykjavik Iceland, Faculty of Medicine; Vilnius University; Vilnius Lithuania, Paediatrics and Child Health; University College; Cork Ireland, Department of Paediatric Pneumology and Immunology; Charité - Universitätsmedizin Berlin; Berlin Germany, Institute for Social Medicine, Epidemiology and Health Economics; Charité - Universitätsmedizin Berlin; Berlin Germany, Grabenhenrich, Linus B., Reich, Andreas, McBride, Doreen, Sprikkelman, Aline, Roberts, Graham, Grimshaw, Kate E. C., Fiocchi, Alessandro G., Saxoni-Papageorgiou, Photini, Papadopoulos, Nikolaos G., Fiandor, Ana, Quirce, Santiago, Kowalski, Marek L., Sigurdardottir, Sigurveig T., Dubakiene, Ruta, Hourihane, Jonathan O. B., Rosenfeld, Leonard, Niggemann, Bodo, Keil, Thomas, Beyer, Kirsten, [ 1 ] Robert Koch Inst, Dept Infect Dis Epidemiol, Berlin, Germany Show more [ 2 ] Charite Univ Med Berlin, Dept Dermatol Venerol & Allergol, Berlin, Germany Show more [ 3 ] German Rheumatism Res Ctr, Berlin, Germany [ 4 ] RTI Int, HTA Hlth Econ Strategy & Res, Manchester, Lancs, England Show more [ 5 ] Univ Groningen, Univ Med Ctr Groningen, Dept Pediat Pulmonol & Pediat Allergol, Groningen, Netherlands Show more [ 6 ] Univ Southampton, Univ Child Hlth, Southampton, Hants, England Show more [ 7 ] Univ Southampton, Clin Expt Sci, Southampton, Hants, England Show more [ 8 ] Paediat Hosp Bambino Gesu, Dept Paediat, Rome, Italy Show more [ 9 ] Univ Athens, Dept Allergy & Clin Immunol, Pediat Clin 2, Athens, Greece Show more [ 10 ] Univ Manchester, Div Infect Immun & Resp Med, Manchester, Lancs, England Show more [ 11 ] Hosp Univ La Paz, Alergia Infantil, Madrid, Spain [ 12 ] Med Univ, Dept Immunol Rheumatol & Allergy, Lodz, Poland [ 13 ] Landspitali, Dept Immunol, Reykjavik, Iceland Show more [ 14 ] Vilnius Univ, Fac Med, Vilnius, Lithuania Show more [ 15 ] Univ Coll, Paediat & Child Hlth, Cork, Ireland Show more [ 16 ] Charite Univ Med Berlin, Dept Paediat Pneumol & Immunol, Berlin, Germany Show more [ 17 ] Charite Univ Med Berlin, Inst Social Med Epidemiol & Hlth Econ, Berlin, Germany, Department for Infectious Disease Epidemiology; Robert Koch Institute; Berlin Germany, German Rheumatism Research Center; Berlin Germany, HTA Health Economics Strategy and Research; RTI International; Manchester UK, Department of Pediatric Pulmonology & Pediatric Allergology; University of Groningen, University Medical Center Groningen; Groningen The Netherlands, University Child Health; University of Southampton; Southampton Hampshire UK, Clinical Experimental Sciences; University of Southampton; Southampton Hampshire UK, Department of Paediatrics; Paediatric Hospital Bambino Gesù; Rome Italy, Department of Allergy and Clinical Immunology; 2nd Pediatric Clinic; National & Kapodistrian University of Athens; Athens Greece, Division of Infection Immunity & Respiratory Medicine; University of Manchester; Manchester UK, Alergia Infantil; Hospital Universitario La Paz; Madrid Spain, Department of Immunology, Rheumatology and Allergy; Medical University; Lodz Poland, Department of Immunology; Landspitali - The National University Hospital of Iceland; Reykjavik Iceland, Faculty of Medicine; Vilnius University; Vilnius Lithuania, Paediatrics and Child Health; University College; Cork Ireland, Department of Paediatric Pneumology and Immunology; Charité - Universitätsmedizin Berlin; Berlin Germany, Institute for Social Medicine, Epidemiology and Health Economics; Charité - Universitätsmedizin Berlin; Berlin Germany, Grabenhenrich, Linus B., Reich, Andreas, McBride, Doreen, Sprikkelman, Aline, Roberts, Graham, Grimshaw, Kate E. C., Fiocchi, Alessandro G., Saxoni-Papageorgiou, Photini, Papadopoulos, Nikolaos G., Fiandor, Ana, Quirce, Santiago, Kowalski, Marek L., Sigurdardottir, Sigurveig T., Dubakiene, Ruta, Hourihane, Jonathan O. B., Rosenfeld, Leonard, Niggemann, Bodo, Keil, Thomas, and Beyer, Kirsten
Abstract: To access publisher's full text version of this article click on the hyperlink below, BACKGROUND: Blinded food challenges are considered the current gold standard for the diagnosis of food allergies. We used data from a pan-European multicenter project to assess differences between study centers, aiming to identify the impact of subjective aspects for the interpretation of oral food challenges. METHODS: Nine study centers of the EuroPrevall birth cohort study about food allergy recruited 12 049 newborns and followed them for up to 30 months in regular intervals. Intensive training was conducted and every center visited to ensure similar handling of the protocols. Suspected food allergy was clinically evaluated by double-blind, placebo-controlled food challenges using a nine dose escalation protocol. The primary challenge outcomes based on physician's appraisal were compared to documented signs and symptoms. RESULTS: Of 839 challenges conducted, study centers confirmed food allergy in 15.6% to 53.6% of locally conducted challenges. Centers reported 0 to 16 positive placebo challenges. Worsening of eczema was the most common sign when challenged with placebo. Agreement between documented objective signs and the challenge outcome assigned by the physician was heterogeneous, with Cohen's kappa spanning from 0.42 to 0.84. CONCLUSIONS: These differences suggest that the comparison of food challenge outcomes between centers is difficult despite common protocols and training. We recommend detailed symptom assessment and documentation as well as objective sign-based challenge outcome algorithms to assure accuracy and comparability of blinded food challenges. Training and supervision of staff conducting food challenges is a mandatory component of reliable outcome data.

12. SOUND TRANSMISSION THROUGH A RIB-STIFFENED PLATE: COMPARISONS OF A LIGHT-FLUID APPROXIMATION WITH EXPERIMENTAL RESULTS

Author: MAURY, C. and MATTEI, P.-O.
Published: 2002
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13. Remote assessment of ADHD in children and adolescents : recommendations from the European ADHD Guidelines Group following the clinical experience during the COVID-19 pandemic

Author: Santosh, P., Cortese, S., Hollis, C., Bölte, S., Daley, D., Coghill, David, Holtmann, M., Sonuga-Barke, E. J. S., Buitelaar, J., Banaschewski, Tobias, Stringaris, A., Döpfner, M., Van der Oord, S., Carucci, S., Brandeis, D., Nagy, P., Ferrin, M., Baeyens, D., van den Hoofdakker, B. J., Purper-Ouakil, D., Ramos-Quiroga, A., Romanos, M., Soutullo, C. A., Thapar, A., Wong, I. C. K., Zuddas, A., Galera, C., Simonoff, E., Universitat Autònoma de Barcelona, University of Zurich, Institut Català de la Salut, [Santosh P] Department of Child and Adolescent Psychiatry, Institute of Psychology, Psychiatry and Neuroscience, King’s College London, London, UK. Centre for Interventional Paediatric Psychopharmacology and Rare Diseases, South London and Maudsley NHS Foundation Trust, London, UK. HealthTracker Ltd, Gillingham, Kent, UK. [Cortese S] Centre for Innovation in Mental Health, School of Psychology, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, UK. Clinical and Experimental Sciences (CNS and Psychiatry), Faculty of Medicine, University of Southampton, Southampton, UK. Solent NHS Trust, Southampton, UK. Hassenfeld Children’s Hospital at NYU Langone, New York University Child Study Center, New York City, NY, USA. Mental Health and Clinical Neurosciences, School of Medicine, University of Nottingham, Nottingham, UK. [Hollis C] School of Medicine, National Institute for Health Research (NIHR) MindTech Mental Health MedTech Cooperative, NIHR Nottingham Biomedical Research Centre, Institute of Mental Health, Mental Health and Clinical Neurosciences, University of Nottingham, Nottingham, UK. [Bölte S] Center of Neurodevelopmental Disorders (KIND), Centre for Psychiatry Research, Department of Women’s and Children’s Health, Karolinska Institute and Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden. Child and Adolescent Psychiatry, Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden. Curtin Autism Research Group, Curtin School of Allied Health, Curtin University, Perth, WA, Australia. [Daley D] NTU Psychology, School of Social Science, Nottingham Trent University, Nottingham, UK. [Coghill D] Departments of Paediatrics and Psychiatry, University of Melbourne, Melbourne, VIC, Australia. Murdoch Children’s Research Institute, Melbourne, VIC, Australia. Royal Children’s Hospital, Melbourne, Melbourne, VIC, Australia. [Ramos-Quiroga A] Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain, and Vall d'Hebron Barcelona Hospital Campus
Subjects: Pandemic, European ADHD Guidelines Group (EAGG), COVID-19, Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [DISEASES], 610 Medicine & health, Remote assessment, General Medicine, 10058 Department of Child and Adolescent Psychiatry, Perinatology and Child Health, Adolescents, COVID-19 (Malaltia), Pediatrics, Psychiatry and Mental health, Trastorn per dèficit d'atenció amb hiperactivitat, Mental Disorders::Neurodevelopmental Disorders::Attention Deficit and Disruptive Behavior Disorders::Attention Deficit Disorder with Hyperactivity [PSYCHIATRY AND PSYCHOLOGY], Assistència sanitària, Pediatrics, Perinatology and Child Health, virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus [ENFERMEDADES], Developmental and Educational Psychology, ADHD, administración de los servicios de salud::gestión de la atención al paciente::prestación sanitaria [ATENCIÓN DE SALUD], trastornos mentales::trastornos del desarrollo neurológico::trastornos conductuales disruptivos y déficit de atención::trastornos de déficit de atención con hiperactividad [PSIQUIATRÍA Y PSICOLOGÍA], 10064 Neuroscience Center Zurich, Children, Health Services Administration::Patient Care Management::Delivery of Health Care [HEALTH CARE]
Abstract: Adolescents; COVID-19; Remote assessment Adolescents; COVID-19; Avaluació a distància Adolescentes; COVID-19; Evaluación a distancia The COVID-19 pandemic led ADHD services to modify the clinical practice to reduce in-person contact as much as possible to minimise viral spread. This had far-reaching effects on day-to-day clinical practice as remote assessments were widely adopted. Despite the attenuation of the acute threat from COVID, many clinical services are retaining some remote practices. The lack of clear evidence-based guidance about the most appropriate way to conduct remote assessments meant that these changes were typically implemented in a localised, ad hoc, and un-coordinated way. Here, the European ADHD Guidelines Group (EAGG) discusses the strengths and weaknesses of remote assessment methods of children and adolescents with ADHD in a narrative review based on available data and expert opinions to highlight key recommendations for future studies and clinical practice. We conclude that going forward, despite remote working in clinical services functioning adequately during the pandemic, all required components of ADHD assessment should still be completed following national/international guidelines; however, the process may need adaptation. Social restrictions, including changes in education provision, can either mask or exacerbate features associated with ADHD and therefore assessment should carefully chart symptom profile and impairment prior to, as well as during an ongoing pandemic. While remote assessments are valuable in allowing clinical services to continue despite restrictions and may have benefits for routine care in the post-pandemic world, particular attention must be paid to those who may be at high risk but not be able to use/access remote technologies and prioritize these groups for conventional face-to-face assessments.
Published: 2023

14. Studies of lead(II) complexes of substituted calix[4]diquinones: the remarkable self-assembly of a novel redox-active 3D channel network.

Author: Beer, Paul D., Drew, Michael G. B., GalePresent address: Department of Chemistry University of Southampton Southampton UK SO17 1BJ., Philip A., OgdenPresent address: School of Applied Chemistry Curtin University of Technology Perth Western Australia., Mark I., and Powell, Harold R.
Published: 2000
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15. Northern hemisphere Holocence land-cover reconstructions from fossil pollen data

Author: Dawson, Andria, Cao, Xianyong, Chaput, Michelle, Hopla, Emma, Kaplan, Jed, Furong, Li, Edwards, Mary, Fyfe, Ralph, Gajewski, Konrad, Goring, Simon, Herzschuh, Ulrike, Mazier, Florence, Sugita, Shinya, Williams, Jack, Gaillard, M.J., Mount Royal University, Alfred Wegener Institute for Polar and Marine Research (AWI), University of Ottawa [Ottawa], University of Southampton, Southampton, United Kingdom., University of Oxford, Oxford, United Kingdom, Linnaeus University, University of Southampton, Southampton, United Kingdom, Plymouth University, Plymouth, United Kingdom, Université d'Ottawa [Ontario] (uOttawa), University of Wisconsin, Madison, Madison, USA, Géographie de l'environnement (GEODE), Université Toulouse - Jean Jaurès (UT2J)-Centre National de la Recherche Scientifique (CNRS), Tallinn University, and Gil, Emilie
Subjects: [SDE.MCG] Environmental Sciences/Global Changes, [SHS.ENVIR] Humanities and Social Sciences/Environmental studies, [SHS.GEO] Humanities and Social Sciences/Geography, [SDE.MCG]Environmental Sciences/Global Changes, [SHS.ENVIR]Humanities and Social Sciences/Environmental studies, HOLOCENE, northern hemisphere, [SHS.GEO]Humanities and Social Sciences/Geography, climate, pollen data
Abstract: International audience; Terrestrial ecosystems play an important role in Earth systems processes, yet we still do not fully understand the feedbacks between these ecosystems and Earth’s climate. These ecosystem processes operate at multiple timescales; fast processes occur at sub-annual timescales, and slow processes, driven by changes in forest composition and structure, occur over decadal and longer timescales. Slow processes are rarely directly observed from instrumental data, yet are critical to understanding the stability of the terrestrial biosphere over the coming decades. Networks of paleoecological data, particularly sedimentary pollen data, offer our strongest observational constraint on long-term vegetation dynamics and underlying processes and feedbacks. We reconstruct land-cover for the Holocene for the Northern Hemisphere. To do this, we use: (i) networks of fossil pollen records - the most reliable paleoecological proxy for land-cover; (ii) estimates of pollen productivity and fall speed, and (iii) a model of pollen-vegetation relationships, REVEALS (Sugita, 2007). For the Northern Hemisphere, we estimate the fraction of summergreen trees, evergreen trees, and open land. To determine the differences between these pollen-based reconstructions and land-use scenarios that are more commonly used land-use models, we compare the fraction of open land with estimates of deforestation from the anthropogenic land-cover change (ALCC) scenarios generated by KK10 (Kaplan et al., 2009). Identifying cause to these differences provides an opportunity for improvement in ALCCs used to inform both global earth system and dynamic vegetation models.This work results in improved understanding of the history of Holocene land-use change over a large spatial extent and slow ecosystem processes, the biogeochemical and physical forcings from past anthropogenic land-cover change on climate, and the long-term carbon dioxide budget. It is a contribution to PAGES LandCover6k.
Published: 2019

16. Extending the phenotypes associated with <scp> TRIO </scp> gene variants in a cohort of 25 patients and review of the literature

Author: Gabriella Gazdagh, David Hunt, Anna Maria Cueto Gonzalez, Monserrat Pons Rodriguez, Ayeshah Chaudhry, Marcos Madruga, Fleur Vansenne, Deborah Shears, Aurore Curie, Eva‐Lena Stattin, Britt‐Marie Anderlid, Slavica Trajkova, Elena Sukarova Angelovska, Catherine McWilliam, Philip R. Wyatt, Mary O'Driscoll, Giles Atton, Anke K. Bergman, Pia Zacher, Leena D. Mewasingh, Antonio Gonzalez‐Meneses López, Olga Alonso‐Luengo, Htoo A. Wai, Ottilie Rohde, Pauline Boiroux, Anne Debant, Susanne Schmidt, Diana Baralle, Institut Català de la Salut, [Gazdagh G] Wessex Clinical Genetics Service, Princess Anne Hospital, University Hospital Southampton NHS Trust, Southampton, UK. Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK. [Hunt D] Wessex Clinical Genetics Service, Princess Anne Hospital, University Hospital Southampton NHS Trust, Southampton, UK. [Cueto Gonzalez AM] Servei de Genètica Clínica i Molecular, Vall d'Hebron Hospital Universitari, Barcelona, Spain. [Pons Rodriguez M] Hospital Universitari Son Espases, Palma, Illes Balears, Spain. [Chaudhry A] Department of Laboratory Medicine and Genetics, Trillium Health Partners, Mississauga, Ontario, Canada. Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada. [Madruga M] Hospital Viamed Santa Angela De la Cruz, Sevilla, Spain, and Vall d'Hebron Barcelona Hospital Campus
Subjects: enfermedades del sistema nervioso::malformaciones del sistema nervioso [ENFERMEDADES], phenotype, Nervous System Diseases::Nervous System Malformations [DISEASES], fenómenos genéticos::variación genética::mutación::mutación de sentido erróneo [FENÓMENOS Y PROCESOS], macrocephaly, Sistema nerviós - Malalties - Aspectes genètics, Fenotip, spectrin, Anomalies cromosòmiques, GEFD, Genetic Phenomena::Phenotype [PHENOMENA AND PROCESSES], Genetics, TRIO gene, Malformacions, Genetic Phenomena::Genetic Variation::Mutation::Mutation, Missense [PHENOMENA AND PROCESSES], microcephaly, Medical Genetics, fenómenos genéticos::fenotipo [FENÓMENOS Y PROCESOS], Genetics (clinical), Medicinsk genetik
Abstract: TRIO gene; Macrocephaly; Phenotype Gen TRIO; Macrocefàlia; Fenotip Gen TRIO; Macrocefalia; Fenotipo The TRIO gene encodes a rho guanine exchange factor, the function of which is to exchange GDP to GTP, and hence to activate Rho GTPases, and has been described to impact neurodevelopment. Specific genotype-to-phenotype correlations have been established previously describing striking differentiating features seen in variants located in specific domains of the TRIO gene that are associated with opposite effects on RAC1 activity. Currently, 32 cases with a TRIO gene alteration have been published in the medical literature. Here, we report an additional 25, previously unreported individuals who possess heterozygous TRIO variants and we review the literature. In addition, functional studies were performed on the c.4394A > G (N1465S) and c.6244-2A > G TRIO variants to provide evidence for their pathogenicity. Variants reported by the current study include missense variants, truncating nonsense variants, and an intragenic deletion. Clinical features were previously described and included developmental delay, learning difficulties, microcephaly, macrocephaly, seizures, behavioral issues (aggression, stereotypies), skeletal problems including short, tapering fingers and scoliosis, dental problems (overcrowding/delayed eruption), and variable facial features. Here, we report clinical features that have not been described previously, including specific structural brain malformations such as abnormalities of the corpus callosum and ventriculomegaly, additional psychological and dental issues along with a more recognizable facial gestalt linked to the specific domains of the TRIO gene and the effect of the variant upon the function of the encoded protein. This current study further strengthens the genotype-to-phenotype correlation that was previously established and extends the range of phenotypes to include structural brain abnormalities, additional skeletal, dental, and psychiatric issues. This work was supported by grants from the Agence Nationale de la Recherche to Anne Debant (ANR-2019 TRIOTISM). Diana Baralle is supported by National Institute for Health Research (NIHR) (RP-2016-07-011) research professorship.
Published: 2023

17. The Heidelberg Laureate Forum on the moving frontier between mathematics and computer science

Author: Baarslag, Tim [Centrum Wiskunde & Informatica and Nagoya University of Technology, Nagoya, Japan and University of Southampton, Southampton, England and Delft University of Technology]
Published: 2017
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18. Towards mapping the late Quaternary vegetation change of Europe

Author: Giesecke, T., Davis, B., Brewer, S., Finsinger, W., Wolters, S., Blaauw, M., de Beaulieu, J.-L., Binney, H., Fyfe, R.M., Gaillard, M.-J., Gil-Romera, G., van der Knaap, W.O., Kunes, P., Kühl, N., van Leeuwen, J.F.N., Leydet, M., Lotter, A.F., Ortu, E., Semmler, M., Bradshaw, R.H.W., Coastal dynamics, Fluvial systems and Global change, Dep Biologie, Palaeo-ecologie, Department of Geography, University of Liverpool-University of Liverpool, ÉcolePolytechniqueFédérale de Lausanne (EPFL), School of Architecture, Civil and Environmental, Centre européen de recherche et d'enseignement des géosciences de l'environnement (CEREGE), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Collège de France (CdF (institution))-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Recherche Agronomique (INRA), Institut des Sciences de l'Evolution de Montpellier (UMR ISEM), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Centre National de la Recherche Scientifique (CNRS)-Institut de recherche pour le développement [IRD] : UR226, Queen's University [Belfast] (QUB), Institut méditerranéen de biodiversité et d'écologie marine et continentale (IMBE), Avignon Université (AU)-Aix Marseille Université (AMU)-Institut de recherche pour le développement [IRD] : UMR237-Centre National de la Recherche Scientifique (CNRS), Palaeoecology Laboratory, University of Southampton-University of Southampton, School of Geography, Plymouth University-Plymouth University, Department of Biology and Environmental Science, Institute of Plant Sciences, University of Bern, Environnements, Dynamiques et Territoires de la Montagne (EDYTEM), Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Centre européen de recherche et d'enseignement de géosciences de l'environnement ( CEREGE ), Centre National de la Recherche Scientifique ( CNRS ) -Institut de Recherche pour le Développement ( IRD ) -Aix Marseille Université ( AMU ) -Collège de France ( CdF ) -Institut National de la Recherche Agronomique ( INRA ) -Institut national des sciences de l'Univers ( INSU - CNRS ), Institut des Sciences de l'Evolution de Montpellier ( ISEM ), Université de Montpellier ( UM ) -Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique ( CNRS ), Queen's University [Belfast] ( QUB ), Institut Méditerranéen d'Ecologie et de Paléoécologie ( IMEP ), Université Paul Cézanne - Aix-Marseille 3-Université de Provence - Aix-Marseille 1-Université d'Avignon et des Pays de Vaucluse ( UAPV ) -Centre National de la Recherche Scientifique ( CNRS ), University of Southampton [Southampton]-University of Southampton [Southampton], University of Plymouth-University of Plymouth, Institut méditerranéen de biodiversité et d'écologie marine et continentale ( IMBE ), Université d'Avignon et des Pays de Vaucluse ( UAPV ) -Aix Marseille Université ( AMU ) -Institut de recherche pour le développement [IRD] : UMR237-Centre National de la Recherche Scientifique ( CNRS ), Environnements, Dynamiques et Territoires de la Montagne ( EDYTEM ), Université Savoie Mont Blanc ( USMB [Université de Savoie] [Université de Chambéry] ) -Centre National de la Recherche Scientifique ( CNRS ), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Collège de France (CdF)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Institut National de la Recherche Agronomique (INRA), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École pratique des hautes études (EPHE)-Université de Montpellier (UM)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut de recherche pour le développement [IRD] : UMR237-Aix Marseille Université (AMU)-Avignon Université (AU), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche pour le Développement (IRD)-Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS), Environnements, Dynamiques et Territoires de Montagne (EDYTEM), Coastal dynamics, Fluvial systems and Global change, Dep Biologie, and Palaeo-ecologie
Subjects: 010506 paleontology, Archeology, 010504 meteorology & atmospheric sciences, [ SDV.BV.BOT ] Life Sciences [q-bio]/Vegetal Biology/Botanics, [SDE.MCG]Environmental Sciences/Global Changes, Climate change, Plant Science, 580 Plants (Botany), 01 natural sciences, [ SDV.SA.SF ] Life Sciences [q-bio]/Agricultural sciences/Silviculture, forestry, law.invention, Paleontology, [SDV.SA.SF]Life Sciences [q-bio]/Agricultural sciences/Silviculture, forestry, law, Plantago lanceolata, [ SDU.ENVI ] Sciences of the Universe [physics]/Continental interfaces, environment, Radiocarbon dating, [ SDV.BIBS ] Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], [SDU.ENVI]Sciences of the Universe [physics]/Continental interfaces, environment, Holocene, ComputingMilieux_MISCELLANEOUS, 0105 earth and related environmental sciences, Chronology, [ SDE.BE ] Environmental Sciences/Biodiversity and Ecology, EPD, European pollen database, Age-depth relationships, Age uncertainty, Palaeontology, Earth Sciences, Biogeosciences, Climate Change, Anthropology, Archaeology, Vegetation, [SDV.BV.BOT]Life Sciences [q-bio]/Vegetal Biology/Botanics, [SDE.ES]Environmental Sciences/Environmental and Society, [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], [ SDE.MCG ] Environmental Sciences/Global Changes, 13. Climate action, European Pollen Database, Physical geography, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, Scale (map), Quaternary, Geology, [ SDE.ES ] Environmental Sciences/Environmental and Society
Abstract: 23 páginas.- Thomas Giesecke et.al., The number of well-dated pollen diagrams in Europe has increased considerably over the last 30 years and many of them have been submitted to the European Pollen Database (EPD). This allows for the construction of increasingly precise maps of Holocene vegetation change across the continent. Chronological information in the EPD has been expressed in uncalibrated radiocarbon years, and most chronologies to date are based on this time scale. Here we present new chronologies for most of the datasets stored in the EPD based on calibrated radiocarbon years. Age information associated with pollen diagrams is often derived from the pollen stratigraphy itself or from other sedimentological information. We reviewed these chronological tie points and assigned uncertainties to them. The steps taken to generate the new chronologies are described and the rationale for a new classification system for age uncertainties is introduced. The resulting chronologies are fit for most continental-scale questions. They may not provide the best age model for particular sites, but may be viewed as general purpose chronologies. Taxonomic particularities of the data stored in the EPD are explained. An example is given of how the database can be queried to select samples with appropriate age control as well as the suitable taxonomic level to answer a specific research question. The readers are reques, We wish to thank all those who have contributed data to the EPD. Keith Bennett provided valuable comments in discussions and to the manuscript.
Published: 2013

19. Risk-Adjusted Cancer Screening and Prevention (RiskAP): Complementing Screening for Early Disease Detection by a Learning Screening Based on Risk Factors

Author: Per Hall, Diana Eccles, Peter Dabrock, Sabine C. Linn, Tade Spranger, Peter Devilee, Judith Balmaña, Kerstin Rhiem, Stefania Boccia, Björn Schmitz-Luhn, Bettina Borisch, Christiane Woopen, Alexander Katalinic, Wolfgang Gaissmaier, Dominique Stoppa-Lyonnet, Stefanie Houwaart, Rita K. Schmutzler, Paul D.P. Pharoah, Marc van den Bulcke, Karin Kast, Jacek Gronwald, Johannes Jozef Marten van Delden, Stefan Huster, Sowmiya Moorthie, Günter Emons, Institut Català de la Salut, [Schmutzler RK] Center Familial Breast and Ovarian Cancer and Center of Integrated Oncology (CIO), University Hospital Cologne, Cologne, Germany. [Schmitz-Luhn B] Cologne Center for Ethics, Rights, Economics, and Social Sciences of Health (ceres), University of Cologne, and Research Unit Ethics, University Hospital of Cologne, Cologne, Germany. [Borisch B] Institute of Global Health, University of Geneva, Geneva, Switzerland. [Devilee P] Leids Universitair Medisch Zentrum, Universiteit Leiden, Leiden, The Netherlands. [Eccles D] Clinical Trials Unit, University of Southampton, Southampton, UK. [Hall P] Karolinska Institutet, Stockholm, Sweden. [Balmaña J] Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain, and Vall d'Hebron Barcelona Hospital Campus
Subjects: ELSI ethical, Otros calificadores::Otros calificadores::/prevención & control [Otros calificadores], medicine.medical_specialty, social implications, Neoplasms::Neoplasms by Site::Breast Neoplasms [DISEASES], diagnóstico::diagnóstico precoz::detección precoz del cáncer [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], Review Article, Risk-adjusted prevention, técnicas de investigación::métodos epidemiológicos::estadística como asunto::probabilidad::riesgo::factores de riesgo [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], Individual risk, Other subheadings::Other subheadings::/prevention & control [Other subheadings], Breast cancer, ddc:150, Cancer screening, Medicine, Mama - Càncer - Diagnòstic, Intensive care medicine, Settore MED/42 - IGIENE GENERALE E APPLICATA, legal, Risk adjusted, neoplasias::neoplasias por localización::neoplasias de la mama [ENFERMEDADES], Cancer prevention, business.industry, Early disease, Evidence-generating care, Mama - Càncer - Factors de risc, Increased risk, Mama - Càncer - Prevenció, Oncology, Preventive intervention, Risk-adjusted prevention · Breast cancer · Evidencegenerating care · ELSI ethical, legal, social implications, Surgery, Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], Genetic risk factor, business, ELSI ethical, legal, social implications, Diagnosis::Early Diagnosis::Early Detection of Cancer [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT]
Abstract: Breast cancer; Evidence-generating care; Risk-adjusted prevention Cáncer de mama; Atención generadora de evidencia; Prevención ajustada al riesgo Càncer de mama; Atenció generadora d'evidències; Prevenció ajustada al risc Background: Risk-adjusted cancer screening and prevention is a promising and continuously emerging option for improving cancer prevention. It is driven by increasing knowledge of risk factors and the ability to determine them for individual risk prediction. However, there is a knowledge gap between evidence of increased risk and evidence of the effectiveness and efficiency of clinical preventive interventions based on increased risk. This gap is, in particular, aggravated by the extensive availability of genetic risk factor diagnostics, since the question of appropriate preventive measures immediately arises when an increased risk is identified. However, collecting proof of effective preventive measures, ideally by prospective randomized preventive studies, typically requires very long periods of time, while the knowledge about an increased risk immediately creates a high demand for action. Summary: Therefore, we propose a risk-adjusted prevention concept that is based on the best current evidence making needed and appropriate preventive measures available, and which is constantly evaluated through outcome evaluation, and continuously improved based on these results. We further discuss the structural and procedural requirements as well as legal and socioeconomical aspects relevant for the implementation of this concept. The project was funded by the German Federal Ministry of Health (grant No. 2515FSB401 to Rita Schmutzler and Christiane Woopen) for supporting the international expert meetings, and a grant of the EU Horizon 2020 program, BRIDGES (grant No. 634935, PI Peter Devilee, WP5-PI Rita Schmutzler), for the compilation of the most recent findings of genetic risk prediction.
Published: 2021

20. International BEAT-PCD Consensus Statement for Infection Prevention and Control for Primary Ciliary Dyskinesia in collaboration with ERN-LUNG PCD Core NETWORK and patient representatives

Author: Mieke Boon, Antonio Moreno-Galdó, Jane S. Lucas, Kim G. Nielsen, Bernhard Rindlisbacher, Woolf T. Walker, June K. Marthin, Bernard Maitre, Phil Robinson, Huda Mussaffi, Vendula Martinu, Panayiotis K. Yiallouros, Heymut Omran, Amparo Escribano, Gemma Marsh, Helle Krogh Johansen, Ernst Eber, Claire Hogg, Damien M.S. Destouches, Carmen Casaulta, Petr Pohunek, Eric G. Haarman, Deborah Snijders, Suzanne Crowley, Pediatrics, Amsterdam Reproduction & Development (AR&D), CCA - Cancer biology and immunology, Institut Català de la Salut, [Marthin JK] Danish PCD Centre Copenhagen, Paediatric Pulmonary Service, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark. [Lucas JS] Primary Ciliary Dyskinesia Centre, NIHR Respiratory Biomedical Research Centre, Clinical and Experimental Science, University of Southampton, Southampton, UK. [Boon M] Dept of Paediatrics, University Hospital Gasthuisberg, Leuven, Belgium. [Casaulta C] Division of Paediatric Respiratory Medicine, University Children’s Hospital, Bern, Switzerland. [Crowley S] Paediatric Dept of Allergy and Lung Diseases, Oslo University Hospital, Oslo, Norway. [Destouches DMS] Association des Patients Ayant une Dyskinésie Ciliaire Primitive, Limeil-Brevannes, France. [Moreno-Galdó A] Servei de Pediatria, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. CIBER of Rare Diseases (CIBERER), Instituto de Salud Carlos III (ISCIII), Madrid, Spain, and Vall d'Hebron Barcelona Hospital Campus
Subjects: Otros calificadores::Otros calificadores::/prevención & control [Otros calificadores], Infeccions respiratòries en els infants, Primary Ciliary Dyskinesia, Statement (logic), Respiratory System, MULTICENTER, RECOMMENDATIONS, 0302 clinical medicine, Original Research Articles, Pandemic, STENOTROPHOMONAS-MALTOPHILIA, Infection control, Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Chronic Disease [DISEASES], 030212 general & internal medicine, Primary ciliary dyskinesia, Malalties transmissibles - Transmissió, Environmental Health::Health::Environmental Illness::Communicable Diseases::Communicable Disease Control [PUBLIC HEALTH], FOUNDATION, biology, Transmission (medicine), Congenital, Hereditary, and Neonatal Diseases and Abnormalities::Congenital Abnormalities::Abnormalities, Multiple::Ciliopathies::Congenital, Hereditary, and Neonatal Diseases and Abnormalities::Ciliary Motility Disorders [DISEASES], afecciones patológicas, signos y síntomas::procesos patológicos::atributos de la enfermedad::enfermedad crónica [ENFERMEDADES], salud ambiental::salud::enfermedad ambiental::enfermedades transmisibles::control de enfermedades transmisibles [SALUD PÚBLICA], medicine.anatomical_structure, Medicine, Patient representatives, Life Sciences & Biomedicine, Pulmonary and Respiratory Medicine, medicine.medical_specialty, 610 Medicine & health, enfermedades y anomalías neonatales congénitas y hereditarias::anomalías congénitas::anomalías múltiples::ciliopatías::enfermedades y anomalías neonatales congénitas y hereditarias::trastornos de la motilidad ciliar [ENFERMEDADES], Other subheadings::Other subheadings::/prevention & control [Other subheadings], 03 medical and health sciences, otorhinolaryngologic diseases, medicine, Intensive care medicine, Science & Technology, CYSTIC-FIBROSIS, Lung, business.industry, PSEUDOMONAS-AERUGINOSA, Malalties cròniques - Prevenció, CARE, EFFICACY, medicine.disease, biology.organism_classification, respiratory tract diseases, 030228 respiratory system, Nontuberculous mycobacteria, 610 Medizin und Gesundheit, business
Abstract: Introduction In primary ciliary dyskinesia (PCD) impaired mucociliary clearance leads to recurrent airway infections and progressive lung destruction, and concern over chronic airway infection and patient-to-patient transmission is considerable. So far, there has been no defined consensus on how to control infection across centres caring for patients with PCD. Within the BEAT-PCD network, COST Action and ERS CRC together with the ERN-Lung PCD core a first initiative has now been taken towards creating such a consensus statement. Methods A multidisciplinary international PCD expert panel was set up to create a consensus statement for infection prevention and control (IP&C) for PCD, covering diagnostic microbiology, infection prevention for specific pathogens considered indicated for treatment and segregation aspects. Using a modified Delphi process, consensus to a statement demanded at least 80% agreement within the PCD expert panel group. Patient organisation representatives were involved throughout the process. Results We present a consensus statement on 20 IP&C statements for PCD including suggested actions for microbiological identification, indications for treatment of Pseudomonas aeruginosa, Burkholderia cepacia and nontuberculous mycobacteria and suggested segregation aspects aimed to minimise patient-to-patient transmission of infections whether in-hospital, in PCD clinics or wards, or out of hospital at meetings between people with PCD. The statement also includes segregation aspects adapted to the current coronavirus disease 2019 (COVID-19) pandemic. Conclusion The first ever international consensus statement on IP&C intended specifically for PCD is presented and is targeted at clinicians managing paediatric and adult patients with PCD, microbiologists, patient organisations and not least the patients and their families., For the first time ever, an international consensus statement for infection prevention and control in PCD is presented. A total of 20 statements were developed in a collaboration of BEAT-PCD, COST Action, ERS CRC and ERN-LUNG PCD Core Network. https://bit.ly/3yuahKt
Published: 2021

21. Severe Chronic Allergic (and related) Diseases: a uniform approach- a MeDALL- GA(2)LEN-ARIA Position Paper

Author: WHO Collaborating Center for Asthma, Rhinitis, Bousquet, J, Anto, Jm, Demoly, P, Schünemann, Hj, Togias, A, Akdis, M, Auffray, C, Bachert, C, Bieber, T, Bousquet, Pj, Carlsen, Kh, Casale, Tb, Cruz, Aa, Keil, T, Lodrup Carlsen KC, Maurer, M, Ohta, K, Papadopoulos, Ng, Roman Rodriguez, M, Samolinski, B, Agache, I, Andrianarisoa, A, Ang, Cs, Annesi Maesano, I, Ballester, F, Baena Cagnani CE, Basagaña, X, Bateman, Ed, Bel, Eh, Bedbrook, A, Beghe', Bianca, Beji, M, Ben Kheder, A, Benet, M, Bennoor, Ks, Bergmann, Kc, Berrissoul, F, Bindslev Jensen, C, Bleecker, Er, Bonini, S, Boner, Al, Boulet, Lp, Brightling, Ce, Brozek, Jl, Bush, A, Busse, Ww, Camargos, Pa, Canonica, Gw, Carr, W, Cesario, A, Chen, Yz, Chiriac, Am, Costa, Dj, Cox, L, Custovic, A, Dahl, R, Darsow, U, Didi, T, Dolen, Wk, Douagui, H, Dubakiene, R, El Meziane, A, Fonseca, Ja, Fokkens, Wj, Fthenou, E, Gamkrelidze, A, Garcia Aymerich, J, Gerth van Wijk, R, Gimeno Santos, E, Guerra, S, Haahtela, T, Haddad, H, Hellings, Pw, Hellquist Dahl, B, Hohmann, C, Howarth, P, Hourihane, Jo, Humbert, M, Jacquemin, B, Just, J, Kalayci, O, Kaliner, Ma, Kauffmann, F, Kerkhof, M, Khayat, G, Koffi N'Goran, B, Kogevinas, M, Koppelman, Gh, Kowalski, Ml, Kull, I, Kuna, P, Larenas, D, Lavi, I, Le, Lt, Lieberman, P, Lipworth, B, Mahboub, B, Makela, Mj, Martin, F, Martinez, Fd, Marshall, Gd, Mazon, A, Melen, E, Meltzer, Eo, Mihaltan, F, Mohammad, Y, Mohammadi, A, Momas, I, Morais Almeida, M, Mullol, J, Muraro, A, Naclerio, R, Nafti, S, Namazova Baranova, L, Nawijn, Mc, Nyembue, Td, Oddie, S, O'Hehir, Re, Okamoto, Y, Orru, Mp, Ozdemir, C, Ouedraogo, Gs, Palkonen, S, Panzner, P, Passalacqua, G, Pawankar, R, Pigearias, B, Pin, I, Pinart, M, Pison, C, Popov, Ta, Porta, D, Postma, Ds, Price, D, Rabe, Kf, Ratomaharo, J, Reitamo, S, Rezagui, D, Ring, J, Roberts, R, Roca, J, Rogala, B, Romano, A, Rosado Pinto, J, Ryan, D, Sanchez Borges, M, Scadding, Gk, Sheikh, A, Simons, Fe, Siroux, V, Schmid Grendelmeier PD, Smit, Ha, Sooronbaev, T, Stein, Rt, Sterk, Pj, Sunyer, J, Terreehorst, I, Toskala, E, Tremblay, Y, Valenta, R, Valeyre, D, Vandenplas, O, van Weel, C, Vassilaki, M, Varraso, R, Viegi, G, Wang, Dy, Wickman, M, Williams, D, Wöhrl, S, Wright, J, Yorgancioglu, A, Yusuf, Om, Zar, Hj, Zernotti, Me, Zidarn, M, Zhong, N, Zuberbier, T., Beghe', B., Fthenou, E., Boudier, Anne, Hôpital Arnaud de Villeneuve [CHRU Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), IMIM-Hospital del Mar, Generalitat de Catalunya, Center for Research in Environmental Epidemiology (CREAL), Universitat Pompeu Fabra [Barcelona] (UPF)-Catalunya ministerio de salud, CIBER Epidemiologia y Salud Publica, CIBER de Epidemiología y Salud Pública (CIBERESP), Universitat Pompeu Fabra [Barcelona] (UPF), WHO Collaborating Center for Asthma and Rhinitis, Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Pharmacoepidemiologie et évaluation de l'impact des produits de santé sur les populations, Université Bordeaux Segalen - Bordeaux 2-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Clinical Epidemiology and Biostatistics and Medicine, McMaster University [Hamilton, Ontario], National Institute of Allergy and Infectious Diseases [Bethesda] (NIAID-NIH), National Institutes of Health [Bethesda] (NIH), Swiss Institute of Allergy and Asthma Research (SIAF), Universität Zürich [Zürich] = University of Zurich (UZH), Génomique fonctionnelle et biologie systémique pour la santé, Institut des Sciences Biologiques du CNRS, Upper Airway Research Laboratory (URL), Ghent University Hospital, Department of Dermatology and Allergy, VU University Medical Center [Amsterdam], Department of Paediatrics, University of Oslo (UiO)-Oslo University Hospital [Oslo], Division of Allergy and Immunology, Department of Medicine, Creighton University, ProAR - FMB, Federal University of Bahia School of Medicine, Epidemiology and Health Economics, Instittute of Social Health-Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Department of Dermatology, Medical School-Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Division of Respiratory Medicine and Allergology, Teikyo University School of Medicine, Allergy Department, 2nd Pediatric Clinic, Son Pisa Primary Care Centre, IB-Salut Balearic Health Service, Department of Prevention of Environmental Hazards and Allergology, Medical University of Warsaw - Poland-Faculté de Pharmacie de Paris, Department of Allergy and Clinical Immunology, Faculty of Medicine-Transylvania University, Public Hospital Medical Service, Ministry of Health [Mozambique], Epidémiologie des maladies infectieuses et modélisation (ESIM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Center for Public Health Research (CSISP), University of Valencia, Respiratory Medicine, Università degli studi di Genova = University of Genoa (UniGe)-School of Specialization, Faculty of Medicine, Catholic University, Health Sciences Faculty, University of Cape Town, Department of Pulmonology, University of Amsterdam [Amsterdam] (UvA)-Academic Medical Centre, Divisions of Human Genetics Infection, Inflammation and Repair, University of Southampton-School of Medicine, Service de Pneumologie Allergologie, Hôpital La Rabta [Tunis], Service de Pneumologie, Hôpital Abderrahmen Mami, National Asthma Centre, National Institute of Diseases of the Chest and Hospital (NIDCH), Pneumologie / Anesthésie - réanimation / Oxygénothérapie, Hôpital AKS Phnom Penh-Hôpital Provincial de Siemreap, Department of Dermatology and Allergy Center, Odense University Hospital, Center for Genomics and Personalized Medicine, Wake Forest University, Institute of Neurobiology and Molecular Medicine, CNR, Rome, Italy and Department of Medicine-University of Naples Federico II = Università degli studi di Napoli Federico II, Università degli studi di Verona = University of Verona (UNIVR), Institut de cardiologie et de pneumologie, Université Laval [Québec] (ULaval)-Centre Hospitalier de Laval (CH Laval), Department of Respiratory Medicine and Thoracic Surgery, University of Leicester-Institute for Lung Health, Department of Paediatric Respiratory Medicine, Imperial College London-Royal Brompton Hospital-National Heart and Lung Institute [UK], Department of Medicine, University of Wisconsin School of Medicine and Public Health, Department of Pediatrics, Universidade Federal de Minas Gerais [Belo Horizonte] (UFMG)-Medical School, Allergy & Respiratory Diseases, Università degli studi di Genova = University of Genoa (UniGe)-Department of Internal Medicine (DIMI), Allergy & Asthma Associates, University of California [Irvine] (UC Irvine), University of California (UC)-University of California (UC), Deputy Scientific Director, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Pisana, Department of Thoracic Surgery, Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma] (Unicatt), National Cooperative Group of Pediatric Research on Asthma, Asthma Clinic and Education Center of the Capital Institute of Pediatrics, Service des Premiers Soins, Université Montpellier 1 (UM1), Osteopathic College of Medicine, Nova Southeastern University (NSU), Respiratory Research Group, University of Manchester [Manchester]-School of Translational Medicine, Department of Respiratory Diseases, Aarhus University Hospital, Department of Dermatology and Allergy Biederstein, Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM), Service de pneumologie, Centre hospitalier de la région d'Annecy, Service de pneumo-allergologie, Centre Hospitalo-Universitaire de Béni-Messous, Allergy Centre, Vilnius University Antakalnis Hospital, Société Marocaine des Maladies Respiratoires, Centre of Respiratory Diseases and Allergy-Centre commercial Nadia, Allergy Division, Hospital S. João-Centre for Research in Health Technologies and Information Systems (CINTESIS)-Biostatistics and Medical Informatics Department-Porto University Medical School, Department of Otorhinolaryngology, Academic Medical Center - Academisch Medisch Centrum [Amsterdam] (AMC), University of Amsterdam [Amsterdam] (UvA)-University of Amsterdam [Amsterdam] (UvA), Department of Social Medicine, University of Crete [Heraklion] (UOC)-Faculty of Medicine, Health Care, Minister Of Labour-Ministry of Labor, Health and Social Affairs, Section of Allergology, Erasmus Medical Centre, Epidemiology and Biostatistics Division, University of Arizona-Associate Research Scientist, Respiratory Sciences-Arizona Respiratory Center, Helsinki University Hospital-Skin and Allergy Hospital, Centre Hospitalier de Bigorre [Tarbes]-Association Franco-Libanaise de Pneumologie (AFLP), Department of Otorhinolaryngology, Head, and Neck Surgery, University Hospital Leuven, Engineering and the Environment, University of Southampton, Paediatrics and Child Health, University College Cork (UCC), Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Antoine Béclère [Clamart], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de l'Asthme et des Allergies [CHU Trousseau], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Pediatric Allergy and Asthma Unit, Ihsan Dogramaci Children's Hospital-Hacettepe University School of Medicine, Institute for Asthma and Allergy, George Washington University Medical School, Department of Epidemiology, University of Groningen [Groningen]-University Medical Center Groningen [Groningen] (UMCG)-Groningen Research Institute for Asthma and COPD (GRIAC), Université Saint-Joseph de Beyrouth (USJ)-Faculté de Médecine-Hôtel-Dieu de France, Service des Maladies Respiratoires, CHU de Cocody-UFR des Sciences Médicales, Pediatric Pulmonology, Allergology & Epidemiology, University of Groningen [Groningen]-University Medical Center Groningen [Groningen] (UMCG)-Beatrix Children's Hospital-Groningen Research Institute for Asthma and COPD, Department of Clinical Immunology and Allergy, Medical University of Łódź (MUL)-Faculty ot Medicine, Centre for Allergy Research, Karolinska Institutet [Stockholm], Department of Clinical Science and Education, Division of Internal Medicine, Asthma and Allergy, Medical University of Łódź (MUL)-Barlicki University Hospital, Hospital Medica Sur, Physiology Department, University of Medicine and Pharmacy, Division of Allergy Immunology, Department of Medicine-The University of Tennessee Health Science Center [Memphis] (UTHSC), university of dundee asthma - allergic rhinitis - COPD - beta-2-adrenoceptor, University of Dundee, Pulmonary and allergy unit, American University of Sharjah-Rashid Hospital-Dubai Health Authority (DHA), Association Franco-Vietnamienne de Pneumologie (AFVP), Centre Hospitalier de Compiègne (CHC), Arizona Respiratory Center, Department of Medicine, Clinical Immunology and Allergy, University of Mississippi Medical Center (UMMC), Institute of Environmental Medicine, Karolinska Institutet [Stockholm]-Karolinska University Hospital [Stockholm]-Astrid Lindgren Children's Hospital, Allergy & Asthma Medical Group & Research Center, University of California [San Diego] (UC San Diego), Pneumology Department, Marius Nasta Institute of Pneumology, Department of Internal Medicine, Tishreen University School of Medicine, Association Franco-Marocaine de Pathologie Thoracique (AFMAPATH), Collège National des Pneumologues Marocains, Epidémiologie Environnementale : Impact Sanitaire des Pollutions (EA 4064), Université Paris Descartes - Paris 5 (UPD5), Immunoallergy Department, Hospital CUF Descobertas, Rhinology Unit & Smell Clinic, Universitat de Barcelona (UB)-Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-Department of Medicine-Hospital Clinic-ENT Department, Allergy Unit, Università degli Studi di Padova = University of Padua (Unipd)-Department of Paediatrics, Section of Otolaryngology-Head & Neck Surgery (OHNS), University of Chicago, Clinique des maladies respiratoires, centre hospitalo-universitaire Mustapha Pacha d'Alger (CHUMA), Scientific Center for Children's Health, Russian Academy of Medical Sciences (RAMS), Laboratory of Allergology and Pulmonary Diseases, University of Groningen [Groningen]-University Medical Center Groningen [Groningen] (UMCG)-Department of Pathology and Medical Biology-GRIAC Research Institute, ENT Department, University of Kinshasa (UNIKIN), Bradford Neonatology, Bradford Teaching Hospitals NHS Foundation Trust-Bradford Institute for Health Research, Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital-Monash University Building, AMREP, Chiba University Hospital, Asthme Rhinite allergique, Pharmacie, Division of Pediatric Allergy and Immunology, marmara university, Pédiatrie, Centre Hospitalier National Pédiatrique Charles de Gaulle (CHNP-CDG), European Federation of Allergy (EFA), Airways Diseases Patients' Associations, Department of Allergology and Clinical Immunology, Charles University [Prague] (CU)-Medical Faculty in Pilsen, Immunopharmacology, Nippon Medical School-Medical Research Council Clinical, Laboratoire du Sommeil et de l'Effort, Société de Pneumologie de Langue Française (SPLF)-Clinique St George, Institut d'oncologie/développement Albert Bonniot de Grenoble (INSERM U823), Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de bioénergétique fondamentale et appliquée (LBFA), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Clinic of Allergy and Asthma, Medical University Sofia-Alexander's University Hospital, Regional Health Service - Lazio, Primary Care Respiratory Medicine, University of Aberdeen-Department of General Practice and Primary Care-General Practice Airways Group (GPIAG), Department of Pulmonary Medicine, Leiden University Medical Center (LUMC), Pneumalgia, Centre Hospitalier Regional-Espace Francophone de Pneumologie (EFP)-Société de Pneumologie de l'Océan Indien (SPOI), Association Franco-Algérienne de Pneumologie (AFAP), Espace Francophone de pneumologie de la SPLF, Department of Pneumology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-Hospital Clínic de Barcelona-Institut Clínic del Tórax (ICT)-CIBER de Enfermedades Respiratorias (CIBERES)-University of Barcelona, Allergology and Clinical Immunology, Medical University of Silesia (SUM)-Chair and Clinical Department of Internal Diseases, UCSC-Allergy Unit, Complesso Integrato Columbus-Department of Internal Medicine and Geriatrics, Hospital da Luz, Medical Centre, Woodbrook Medical Centre, Research Fellow, University of Aberdeen-Department of General Practice, Centro Médico Docente La Trinidad, Department of Pharmacology, University College of London [London] (UCL)-The Royal National Throat, Nose and Ear Hospital, Primary Care Research & Development, University of Edinburgh-Centre for Population Health Sciences, Section of Allergy & Clinical Immunology, University of Manitoba [Winnipeg]-Department of Pediatrics & Child Health, Allergy Unit - Department of Dermatology, Julius Center for Health Sciences and Primary Care, University Medical Center [Utrecht], National Centre of Cardiology and Internal Medicine, Ministry of Health Kyrgyz Republic, School of Medicine, Pontifícia Universidade Católica, Department of ENT and Pediatrics, Finnish Institute of Occupational Health, Department of Obstetrics and Gynaecology, Université Laval [Québec] (ULaval)-Faculty of Medicine, Christian Doppler Laboratory for Allergy Research, Medizinische Universität Wien = Medical University of Vienna-Division of Immunopathology-Department of Pathophysiology and Allergy Research-Center for Pathophysiology, Infectiology and Immunology, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Avicenne [AP-HP], Department of Chest Medicine, Mont-Godinne Hospital-Catholic University of Louvain de Mont-Godinne, Department of Primary and Community Care, Radboud University Medical Center [Nijmegen], Epidemiology Unit, National Research Council (CNR)-Institute of Biomedicine and Molecular Immunology (IBIM), Pulmonary Environmental Epidemiology Unit, CNR Institute of Clinical Physiology, Department of Otolaryngology, National University of Singapore (NUS)-Yong Loo Lin School of Medicine, Karolinska Institutet [Stockholm]-Sachs' Children's Hospital, GLP Analytical Facility, School of Pharmacy, Department of Dermatology Division of Immunology, Allergy and Infectious Diseases (DIAID), Medical University of Vienna (MUW), Celal Bayar University School of Medicine, Allergy and Asthma Clinics, The Allergy and Asthma Institute, Department of Paediatrics and Child Health, Respiratory and Allergic Diseases, University Clinic of Respiratory and Allergic Diseases Golnik, State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Diseases-Guangzhou Medical College, Secretary General of the Global Allergy and Asthma European Network (GA2LEN), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], In collaboration with the WHO Collaborating Center for Asthma and Rhinitis, University of Genoa (UNIGE)-School of Specialization, CNR, Rome, Italy and Department of Medicine-University of Naples Federico II, University of Verona (UNIVR), Medical School-Federal University of Minas Gerais, University of Genoa (UNIGE)-Department of Internal Medicine (DIMI), University of California [Irvine] (UCI), University of California-University of California, Catholic University Rome, University of Amsterdam [Amsterdam] (UvA)-Academic Medical Center - Academisch Medisch Centrum [Amsterdam] (AMC), University of Amsterdam [Amsterdam] (UvA), Centre Hospitalier de Bigorre (Tarbes)-Association Franco-Libanaise de Pneumologie (AFLP), CUF-Descobertas Hospital, Universita degli Studi di Padova-Department of Paediatrics, Medical Faculty in Pilsen-Charles University in Prague - the First Faculty of Medicine, Centro Medico-Docente La Trinidad, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]-Instittute of Social Health, Department of Internal Medicine (DIMI)-University of Genoa (UNIGE), Medical University of Silesia-Chair and Clinical Department of Internal Diseases, Dermatology, Internal Medicine, Immunology, Hôpital Arnaud de Villeneuve, Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ), Centre de recherche en épidémiologie et santé des populations ( CESP ), Université de Versailles Saint-Quentin-en-Yvelines ( UVSQ ) -Université Paris-Sud - Paris 11 ( UP11 ) -Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Center for Research in Environmental Epidemiology ( CREAL ), Universitat Pompeu Fabra [Barcelona]-Catalunya ministerio de salud, Universitat Pompeu Fabra [Barcelona], WHO(OMS), Université Bordeaux Segalen - Bordeaux 2-Université de Rouen Normandie ( UNIROUEN ), Normandie Université ( NU ) -Normandie Université ( NU ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), National Institute of Allergy and Infectious Diseases [Bethesda], National Institutes of Health ( NIH ), Swiss Institute of Allergy and Asthma Research ( SIAF ), University of Zürich [Zürich] ( UZH ), Upper Airway Research Laboratory ( URL ), University Medical Center, University of Oslo ( UiO ) -Oslo University Hospital, Charite-Universitatsmedizin Berlin [Berlin]-Instittute of Social Health, Medical School-Charité - University Medicine Berlin, Medical University of Warsaw-Faculté de Pharmacie de Paris, Ministry of Health, Epidémiologie des maladies infectieuses et modélisation ( ESIM ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Center for Public Health Research ( CSISP ), University of Genoa ( UNIGE ) -School of Specialization, University of Amsterdam [Amsterdam] ( UvA ) -Academic Medical Centre, University of Southampton [Southampton]-School of Medicine, Hôpital La Rabta [Tunis), Wake Forest University Health Sciences, CNR, Rome, Italy and Department of Medicine-Second University of Naples, Università degli Studi di Verona, Université Laval-l'Hôpital Laval, Imperial College London-Royal Brompton Hospital-National Heart and Lung Institute, University of Genoa ( UNIGE ) -Department of Internal Medicine (DIMI), Southern California Research, Université Montpellier 1 ( UM1 ), Nova Southeastern University, Technische Universität München [München] ( TUM ), Academic Medical Center [Amsterdam] ( AMC ), University of Amsterdam [Amsterdam] ( UvA ) -University of Amsterdam [Amsterdam] ( UvA ), University of Crete ( UOC ) -Faculty of Medicine, University of Southampton [Southampton], UUniversity College Cork - National University of Ireland, Cork (UCC), Université Paris-Sud - Paris 11 ( UP11 ) -Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Antoine Béclère, Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Trousseau [APHP], University of Groningen [Groningen]-University Medical Center Groningen-Groningen Research Institute for Asthma and COPD (GRIAC), Université Saint-Joseph de Beyrouth ( USJ ) -Faculté de Médecine-Hôtel-Dieu de France, University of Groningen [Groningen]-University Medical Center Groningen-Beatrix Children's Hospital-Groningen Research Institute for Asthma and COPD, Medical University of Łódź ( MUL ) -Faculty ot Medicine, Medical University of Łódź ( MUL ) -Barlicki University Hospital, Department of Medicine-University of Tennessee College for Medicine, Association Franco-Vietnamienne de Pneumologie ( AFVP ), University of Mississippi Medical Center, University of California [San Diego] ( UC San Diego ), Association Franco-Marocaine de Pathologie Thoracique ( AFMAPATH ), Epidémiologie Environnementale : Impact Sanitaire des Pollutions ( EA 4064 ), Université Paris Descartes - Paris 5 ( UPD5 ), Universitat de Barcelona ( UB ) -Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-Department of Medicine-Hospital Clinic-ENT Department, Section of Otolaryngology-Head & Neck Surgery ( OHNS ), University of Groningen [Groningen]-University Medical Center Groningen-Department of Pathology and Medical Biology-GRIAC Research Institute, University Hospital of Kinshasa, European Federation of Allergy ( EFA ), Institut d'oncologie/développement Albert Bonniot de Grenoble ( INSERM U823 ), Université Joseph Fourier - Grenoble 1 ( UJF ) -CHU Grenoble-EFS-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Bioenergétique fondamentale et appliquée ( LBFA ), Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Department of General Practice and Primary Care-General Practice Airways Group (GPIAG)-University of Aberdeen, Association Franco-Algérienne de Pneumologie ( AFAP ), Department of General Practice-University of Aberdeen, University College of London [London] ( UCL ) -The Royal National Throat, Nose and Ear Hospital, University Medical Center Utrecht, Faculty of Medicine-Laval University [Québec], Medical University of Vienna-Division of Immunopathology-Department of Pathophysiology and Allergy Research-Center for Pathophysiology, Infectiology and Immunology, Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Avicenne, National University of Singapore ( NUS ) -Yong Loo Lin School of Medicine, Department of Dermatology Division of Immunology, Allergy and Infectious Diseases ( DIAID ), Secretary General of the Global Allergy and Asthma European Network ( GA2LEN ), Network of Excellence, Charité - Universitätsmedizin Berlin, CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK (BIHR), Universiteit Leiden-Universiteit Leiden, and Medizinische Universität Wien = Medical University of Vienna
Subjects: MESH: Asthma, severity, MESH: Comorbidity, Comorbidity, Severity of Illness Index, urticaria, MESH : Chronic Disease, MESH: Practice Guidelines as Topic, MESH : Dermatitis, Atopic, MESH: Urticaria, risk, 216-31 [Rhinitis, atopy, allergen Int Arch Allergy Immunol. 2012,158(3)], atopic dermatitis, MESH : Rhinitis, MESH: Rhinitis, [ SDV.SPEE ] Life Sciences [q-bio]/Santé publique et épidémiologie, Effective primary care and public health [NCEBP 7], Immunoglobulin E - Asthma - Rhinitis - Rhinosinusitis - Urticaria - Atopic dermatitis, MESH : Practice Guidelines as Topic, Practice Guidelines as Topic, MESH : Comorbidity, MESH : Severity of Illness Index, IgE, MESH: Sinusitis, MESH : Urticaria, MESH: Hypersensitivity, macromolecular substances, MESH : Asthma, Dermatitis, Atopic, rhinitis, SDG 3 - Good Health and Well-being, MESH: Dermatitis, Atopic, MESH: Severity of Illness Index, Hypersensitivity, Humans, Sinusitis, rhinosinusitis, MESH : Hypersensitivity, MESH: Humans, MESH: Chronic Disease, MESH : Humans, Asthma, Atopic dermatitis, Immunoglobulin E, Rhinitis, Rhinosinusitis, Urticaria, asthma, allergy, MESH : Sinusitis, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Chronic Disease, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, control
Abstract: Concepts of disease severity, activity, control and responsiveness to treatment are linked but different. Severity refers to the loss of function of the organs induced by the disease process or to the occurrence of severe acute exacerbations. Severity may vary over time and needs regular follow-up. Control is the degree to which therapy goals are currently met. These concepts have evolved over time for asthma in guidelines, task forces or consensus meetings. The aim of this paper is to generalize the approach of the uniform definition of severe asthma presented to WHO for chronic allergic and associated diseases (rhinitis, chronic rhinosinusitis, chronic urticaria and atopic dermatitis) in order to have a uniform definition of severity, control and risk, usable in most situations. It is based on the appropriate diagnosis, availability and accessibility of treatments, treatment responsiveness and associated factors such as comorbidities and risk factors. This uniform definition will allow a better definition of the phenotypes of severe allergic (and related) diseases for clinical practice, research (including epidemiology), public health purposes, education and the discovery of novel therapies. Copyright (C) 2012 S. Karger AG, Basel
Published: 2012

22. Validation of living with chronic illness scale in a type 2 diabetes mellitus population

Author: Leire Ambrosio, Silvia Corchon, Jorge Caro-Bautista, Eva Timonet-Andreu, David Pérez-Manchón, Gloria Carvajal-Carrascal, Carmen Rodriguez-Blazquez, Alejandra Fuentes-Ramírez, Marta Aranda-Gallardo, Ministerio de Ciencia, Innovación y Universidades (España), European Regional Development Fund, [Caro-Bautista,J] Andalusian Public Health System, District of Primary Health Care of Málaga-Valle del Guadalhorce and Instituto de Investigación Biomédica de Málaga-IBIMA, Málaga, Spain. [Rodríguez-Blázquez,C] National Centre of Epidemiology and CIBERNED, Carlos III Institute of Health, Madrid, Spain. [Perez-Manchon,D] Faculty of Health, Camilo José Cela University, Madrid, Spain. [Timonet-Andreu,E] Department of Cardiology, Costa del Sol Hospital and Instituto de Investigación Biomédica de Málaga-IBIMA, Málaga, Spain. [Carvajal-Carrascal,G, Fuentes-Ramírez,A] Facultad de Enfermería y Rehabilitación, Universidad de La Sabana, Chía, Colombia. [Corchon,S] Faculty of Nursing and Chiropody, University of Valencia, Valencia, Spain. [Aranda-Gallardo,M] Department of Internal Medicine, Costa del Sol Hospital, Marbella, Málaga, Spain. [Ambrosio,L] School of Health Sciences, NIHR ARC Wessex, University of Southampton, Southampton, United Kingdom, and This study has been funded by the Ministry of Science, Innovation and University of the Spanish Government (FEDER/Ministerio de Ciencia, Innovación y Universidades—Agencia Estatal de Investigación/ Proyecto (CSO2017-82691-R)).
Subjects: Male, Intraclass correlation, España, Chronic illness, Geographical Locations::Geographic Locations::Americas::South America::Colombia [Medical Subject Headings], Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Surveys and Questionnaires, Medicine, Persons::Persons::Patients::Outpatients [Medical Subject Headings], education.field_of_study, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Questionnaires [Medical Subject Headings], General Medicine, Middle Aged, Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Personal Satisfaction [Medical Subject Headings], Confirmatory factor analysis, Checklist, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cross-Sectional Studies [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Research Design::Reproducibility of Results [Medical Subject Headings], Diabetes mellitus tipo 2, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Feasibility Studies [Medical Subject Headings], Anthropology, Education, Sociology and Social Phenomena::Social Sciences::Quality of Life [Medical Subject Headings], Long-term condition, Psicometría, lcsh:R858-859.7, Female, Psychometric, Clinical psychology, Adult, Population, Check Tags::Male [Medical Subject Headings], Health Care::Health Services Administration::Organization and Administration::Professional Practice::Referral and Consultation [Medical Subject Headings], Colombia, lcsh:Computer applications to medicine. Medical informatics, Estudio de validación, Psychiatry and Psychology::Behavioral Disciplines and Activities::Psychological Tests::Psychometrics [Medical Subject Headings], Social support, Quality of life (healthcare), Cronbach's alpha, Study validation, Type 2 diabetes mellitus, Humans, COSMIN, Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Data Collection::Checklist [Medical Subject Headings], Persons::Persons::Age Groups::Adult [Medical Subject Headings], education, Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], business.industry, Research, Enfermedad crónica, Public Health, Environmental and Occupational Health, Diseases::Endocrine System Diseases::Diabetes Mellitus::Diabetes Mellitus, Type 2 [Medical Subject Headings], Reproducibility of Results, Persons::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings], Cross-Sectional Studies, Check Tags::Female [Medical Subject Headings], Diabetes Mellitus, Type 2, Spain, Quality of Life, Observational study, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Factor Analysis, Statistical [Medical Subject Headings], business
Abstract: Background Worldwide, type 2 diabetes mellitus (T2DM) is one of the most prevalent chronic diseases and one of those producing greatest impact on patients’ day-to-day quality of life. Our study aim is to validate the “Living with Chronic Illness Scale” for a Spanish-speaking T2DM population. Methods In this observational, international, cross-sectional study, 582 persons with T2DM were recruited in primary care and outpatient hospital consultations, in Spain and Colombia, during the period from May 2018 to June 2019. The properties analysed were feasibility/acceptability, internal consistency, reliability, precision and (structural) content-construct validity including confirmatory factor analysis. The COSMIN checklist was used to assess the methodological/psychometric quality of the instrument. Results The scale had an adequate internal consistency and test retest reliability (Cronbach’s alpha = 0.90; intraclass correlation coefficient = 0.96, respectively). In addition, the instrument is precise (standard error of measurement = 3.34, with values s = 0.56), quality of life (WHOQOL-BREF) (rs = 0.51–0.30) and ssatisfaction with life (SLS-6) (rs = 0.50–0.38). The original 26-items version of the scale did not support totally the confirmatory factor analysis. The COSMIN checklist is favourable for all the properties analysed, although weaknesses are detected for structural validity. Conclusions The LW-CI-T2DM is a valid, reliable and accurate instrument for use in clinical practice to determine how a person’s life is affected by the presence of diabetes. This instrument correlates well with the associated constructs of social support, quality of life and satisfaction. Additional research is needed to determine how well the questionnaire structure performs when robust factor analysis methods are applied.
Published: 2021

23. On the origin of resistive switching volatility in Ni/TiO{sub 2}/Ni stacks

Author: Prodromakis, Themistoklis [Nano Research Group, Electronics and Computer Science, University of Southampton, Southampton, Hampshire, SO17 1BJ (United Kingdom)]
Published: 2016
Full Text: View/download PDF

24. Engineering the switching dynamics of TiO{sub x}-based RRAM with Al doping

Author: Prodromakis, Themistoklis [Nano Group, School of Electronics and Computer Science, University of Southampton, Southampton SO17 1BJ (United Kingdom)]
Published: 2016
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25. Skeletal stem cell and bone implant interactions are enhanced by LASER titanium modification

Author: Oreffo, Richard [Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Institute of Developmental Sciences, University of Southampton, Southampton SO16 6YD (United Kingdom)]
Published: 2016
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26. FIRST SEARCH FOR AN X-RAY–OPTICAL REVERBERATION SIGNAL IN AN ULTRALUMINOUS X-RAY SOURCE

Author: Gandhi, Poshak [School of Physics and Astronomy, University of Southampton, Southampton SO17 1BJ (United Kingdom)]
Published: 2016
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27. Circles in the sea: annual courtship 'torus' behaviour of basking sharks Cetorhinus maximus identified in the eastern North Atlantic Ocean

Author: David W. Sims, Simon D. Berrow, Ken M. O'Sullivan, Nicholas J. Pfeiffer, Richard Collins, Kev L. Smith, Brianna M. Pfeiffer, Paul Connery, Shane Wasik, Lois Flounders, Nuno Queiroz, Nicolas E. Humphries, Freya C. Womersley, Emily J. Southall, The Laboratory, Marine Biological Association, Citadel Hill, Plymouth, UK, Ocean and Earth Science, National Oceanography Centre Southampton, University of Southampton, Southampton, UK, Irish Basking Shark Group, Merchants Quay, Kilrush, Ireland, Marine and Freshwater Research Centre, Department of Natural Resources and the Environment, Atlantic Technological University, Galway, Ireland, SeaFever Productions, Woodview Park, Ennistymon, Ireland, MERC Ecological Consultants, Galway, Ireland, Irish Basking Shark Group, Kilkee, Ireland, Basking Shark Scotland, Oban, UK, CIBIO, Centro de Investigação em Biodiversidade e Recursos Genéticos, InBIO Laboratório Associado, Campus de Vairão, Universidade do Porto, Vairão, Portugal, BIOPOLIS Program in Genomics, Biodiversity and Land Planning, Vairão, Portugal, and David W. Sims is supported by a Marine Biological Association Senior Research Fellowship.
Subjects: Male, Marine and Freshwater Research Centre, Courtship, Sharks, Animals, Female, Seasons, Aquatic Science, Atlantic Ocean, Ecology, Evolution, Behavior and Systematics, Ecosystem
Abstract: Groups of basking sharks engaged in circling behaviour are rarely observed, and their function remains enigmatic in the absence of detailed observations. Here, underwater and aerial video recordings of multiple circling groups of basking sharks during late summer (August and September 2016–2021) in the eastern North Atlantic Ocean showed groups numbering between 6 and 23 non-feeding individuals of both sexes. Sharks swam slowly in a rotating “torus” (diameter range: 17–39 m), with individuals layered vertically from the surface to a maximum depth of 16 m. Within a torus, sharks engaged in close-following, echelon, close-flank approach or parallel-swimming behaviours. Measured shark total body lengths were 5.4–9.5 m (mean LT: 7.3 m ± 0.9 s.d.; median: 7.2 m, n = 27), overlapping known lengths of sexually mature males and females. Males possessed large claspers with abrasions that were also observed on female pectoral fins. Female body colouration was paler than that of males, similar to colour changes observed during courtship and mating in other shark species. Individuals associated with most other members rapidly (within minutes), indicating toroidal behaviours facilitate multiple interactions. Sharks interacted through fin–fin and fin–body contacts, rolling to expose the ventral surfaces to following sharks, and breaching behaviour. Toruses formed in late summer when feeding aggregations in zooplankton-rich thermal fronts switched to non-feeding following and circling behaviours. Collectively, the observations explain a courtship function for toruses. This study highlights northeast Atlantic coastal waters as a critical habitat supporting courtship reproductive behaviour of endangered basking sharks, the first such habitat identified for this species globally. (https://www.youtube.com/watch?v=7i2H1wVOmb4) yes
Published: 2022

28. Near field fluid coupling between internal motion of the organ of Corti and the basilar membrane

Author: Ni, Guangjian [Institute of Sound and Vibration Research, University of Southampton, Southampton (United Kingdom)]
Published: 2015
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29. The electro-mechanical effect from charge dynamics on polymeric insulation lifetime

Author: Vaughan, A. [Faculty of Physical Sciences and Engineering, University of Southampton, Southampton, SO17 1BJ (United Kingdom)]
Published: 2015
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30. Noble Magnificence: Cultures of the Performing Arts in Rome, 1644-1740

Author: Anne-Madeleine Goulet, Michela Berti, Orsetta Baroncelli, Diana Blichmann, Teresa Chirico, Émilie Corswarem, Valeria De Lucca, José María Domínguez, Gloria Giordano, Chiara Pelliccia, Antonella Fabriani Rojas, Cristina Fernandes, Irene Fosi, Natalia Gozzano, Manuela Grillo, Letizia Leli, Sarah Malfatti, Benoît Maréchaux, Margaret Murata, Giulia Veneziano, Barbara Nestola, Alexandra Nigito, Elodie Oriol, Valentina Panzanaro, Maurizio Pegrari, Aldo Roma, Marco Cavietti, Sara Elisa Stangalino, Huub van Der Linden, Centre d'études supérieures de la Renaissance UMR 7323 (CESR), Ministère de la Culture et de la Communication (MCC)-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), Accademia Nazionale di Santa Cecilia [Rome], Université de Liège, University of Southampton, Southampton, University of Southampton, Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] (UCM), Accademia Nazionale di Danza (AND), Conservatorio di musica 'Nicola Sala' di Benevento, Universidade Nova de Lisboa = NOVA University Lisbon (NOVA), Università degli studi 'G. d'Annunzio' Chieti-Pescara [Chieti-Pescara], Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), Accademia dell'Arcadia, Conservatorio di Musica 'San Pietro a Majella' - Napoli, University of Brescia, Ecole française de Rome (EFR), Direzione generale Archivi (DGA), Università degli Studi dell'Aquila = University of L'Aquila (UNIVAQ), Vendrix, Philippe, European Project: 681415,PERFORMART, Goulet, Anne-Madeleine, and Promoting, Patronising and Practising the Arts in Roman Aristocratic Families (1644-1740). The Contribution of Roman Families’ Archives to the History of Performing Arts - PERFORMART - 681415 - INCOMING
Subjects: [SHS.MUSIQ] Humanities and Social Sciences/Musicology and performing arts, [SHS.MUSIQ]Humanities and Social Sciences/Musicology and performing arts
Abstract: International audience
Published: 2022

31. Near-field enhanced optical tweezers utilizing femtosecond-laser nanostructured substrates

Author: Lagoudakis, P. [Department of Physics and Astronomy, University of Southampton, Southampton SO17 1BJ (United Kingdom)]
Published: 2015
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32. Health-Related Quality of Life in SCALOP, a Randomized Phase 2 Trial Comparing Chemoradiation Therapy Regimens in Locally Advanced Pancreatic Cancer

Author: Johnson, Colin [University Surgical Unit, Faculty of Medicine, University Hospital Southampton, Southampton (United Kingdom)]
Published: 2015
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33. X-RAY OUTBURSTS OF ESO 243-49 HLX-1: COMPARISON WITH GALACTIC LOW-MASS X-RAY BINARY TRANSIENTS

Author: Altamirano, Diego [Physics and Astronomy, University of Southampton, Southampton, Hampshire SO17 1BJ (United Kingdom)]
Published: 2015
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34. Polarization sensitive anisotropic structuring of silicon by ultrashort light pulses

Author: Kazansky, Peter [Optoelectronics Research Centre, University of Southampton, Southampton SO17 1BJ (United Kingdom)]
Published: 2015
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35. Switching kinetics of SiC resistive memory for harsh environments

Author: Jiang, L. [Faculty of Engineering and the Environment, University of Southampton, Southampton, Hampshire, United Kingdom, SO171BJ (United Kingdom)]
Published: 2015
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36. Spin noise amplification and giant noise in optical microcavity

Author: Lagoudakis, P. [Department of Physics and Astronomy, University of Southampton, Southampton SO17 1BJ (United Kingdom)]
Published: 2015
Full Text: View/download PDF

37. Multi-field inflation from holography

Author: Skenderis, Kostas [STAG Research Centre and Mathematical Sciences, University of Southampton, Southampton SO17 1BJ (United Kingdom)]
Published: 2015
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38. Tephra Deposition and Bonding With Reactive Oxides Enhances Burial of Organic Carbon in the Bering Sea

Author: Jack Longman, Hayley Manners, Thomas M. Gernon, Martin R. Palmer, Gernon, Thomas M., 2 School of Ocean & Earth Science University of Southampton Southampton UK, Palmer, Martin R., and Manners, Hayley R.
Subjects: Total organic carbon, Atmospheric Science, Global and Planetary Change, Environmental chemistry, ddc:551.9, Environmental Chemistry, Environmental science, Tephra, Deposition (chemistry), General Environmental Science
Abstract: Preservation of organic carbon (OC) in marine sediments exerts a major control on the cycling of carbon in the Earth system. In these marine environments, OC preservation may be enhanced by diagenetic reactions in locations where deposition of fragmental volcanic material called tephra occurs. While the mechanisms by which this process occurs are well understood, site‐specific studies of this process are limited. Here, we report a study of sediments from the Bering Sea (IODP Site U1339D) to investigate the effects of marine tephra deposition on carbon cycling during the Pleistocene and Holocene. Our results suggest that tephra layers are loci of OC burial with distinct δ13C values, and that this process is primarily linked to bonding of OC with reactive metals, accounting for ∼80% of all OC within tephra layers. In addition, distribution of reactive metals from the tephra into non‐volcanic sediments above and below the tephra layers enhances OC preservation in these sediments, with ∼33% of OC bound to reactive phases. Importantly, OC‐Fe coupling is evident in sediments >700,000 years old. Thus, these interactions may help explain the observed preservation of OC in ancient marine sediments., Plain Language Summary: The burial of organic carbon (OC) in marine sediments is one of the major carbon sinks on Earth, meaning that it removes carbon dioxide from the ocean‐atmosphere system. However, the speed at which burial occurs varies across the globe, and is dependent on a range of factors, from the amount of nutrients in the water column, to the type of sediment. Despite evidence suggesting that when tephra is deposited to the seafloor carbon burial is enhanced, very little work has been done to investigate this process. We have therefore analyzed sediments from the Bering Sea, where volcanoes from the Aleutian Islands and Kamchatka regularly deposit tephra in the ocean. We found that OC burial is indeed associated with ash deposition, and importantly, that OC is preserved in the ash layers themselves. We show here that this carbon is preserved effectively because of chemical reactions between the OC and reactive iron, which is released by the ash, creating conditions which preserve carbon for hundreds of thousands of years., Key Points: Tephra layers are loci of marine organic carbon (OC) burial with distinct carbon isotopic compositions. Preservation primarily linked to association of OC with reactive iron phases, accounting for ∼80% of all OC in tephra layers. OC‐reactive Fe coupling is observed in sediments >700,000 years old, indicating long‐term persistence of these complexes., NERC
Published: 2021

39. Improved mechanical and electrical properties in electrospun polyimide/multiwalled carbon nanotubes nanofibrous composites

Author: Chen, George [School of Electronics and Computer Science, University of Southampton, Southampton SO17 1BJ (United Kingdom)]
Published: 2014
Full Text: View/download PDF

40. Dynamic control of spin wave spectra using spin-polarized currents

Author: Fangohr, Hans [Faculty of Engineering and the Environment, University of Southampton, Southampton SO17 1BJ (United Kingdom)]
Published: 2014
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41. Anisotropic Ta{sub 2}O{sub 5} waveguide etching using inductively coupled plasma etching

Author: Charlton, Martin [Nano Research Group, Electronics and Computer Science, Faculty of Physical and Applied Sciences, University of Southampton, Southampton SO17 1BJ (United Kingdom)]
Published: 2014
Full Text: View/download PDF

42. Single beam optical vortex tweezers with tunable orbital angular momentum

Author: Kazansky, Peter [Optoelectronics Research Centre, University of Southampton, Southampton SO17 1BJ (United Kingdom)]
Published: 2014
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43. Unveiling the intrinsic X-ray properties of broad absorption line quasars with a relatively unbiased sample

Author: Shankar, Francesco [School of Physics and Astronomy, University of Southampton, Southampton SO17 IBJ (United Kingdom)]
Published: 2014
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44. P2.17 Comparing villous branching of zebra, horse and human placenta using 3D imaging

Author: Harris, Shelley, Beasley, Olivia, Shotton, Justine, Irvine, Wendy, Constable-Dakeyne, Georgina, Free, Danielle, Cleal, Jane, Gostling, Neil, Chavatte-Palmer, Pascale, lewis, rohan, Faculty of Medicine, University of Southampton, Southampton, UK, Centre for Biological Sciences (University of Southampton), University of Southampton, Marwell Wildlife, Biologie de la Reproduction, Environnement, Epigénétique & Développement (BREED), Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-École nationale vétérinaire d'Alfort (ENVA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), and Leverhulme foundation comparative placentation project
Subjects: [SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health, villous, Placenta, [SDV.BA.ZV]Life Sciences [q-bio]/Animal biology/Vertebrate Zoology, zebra, term, ComputingMilieux_MISCELLANEOUS, horse
Abstract: International audience
Published: 2021

45. Wavelet-based parallel dynamic mesh adaptation for magnetohydrodynamics in the AMROC framework

Author: Margarete Oliveira Domingues, Odim Mendes, Ralf Deiterding, Müller Moreira Lopes, Kai Schneider, Anna Karina Fontes Gomes, National Institute for Space Research [Sao José dos Campos] (INPE), University of Southampton, Southampton, University of Southampton, Instituto Nacional de Pesquisas Espaciais (INPE), Space Geophysics Division (DGE/CEA), Institut de Mathématiques de Marseille (I2M), and Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: General Computer Science, Adaptive mesh refinement, Computer science, [SPI.PLASMA]Engineering Sciences [physics]/Plasmas, General Engineering, FOS: Physical sciences, Context (language use), [PHYS.MECA]Physics [physics]/Mechanics [physics], 010103 numerical & computational mathematics, Computational Physics (physics.comp-ph), Solver, 01 natural sciences, Computational science, 010101 applied mathematics, Wavelet, Feature (computer vision), Polygon mesh, 0101 mathematics, Adaptation (computer science), Physics - Computational Physics, Computational magnetohydrodynamics, ComputingMilieux_MISCELLANEOUS, [MATH.MATH-NA]Mathematics [math]/Numerical Analysis [math.NA]
Abstract: Computational magnetohydrodynamics (MHD) for space physics has become an essential area in understanding the multiscale dynamics of geophysical and astrophysical plasma processes, partially motivated by the lack of space data. Full MHD simulations are typically very demanding and may require substantial computational efforts. In particular, computational space-weather forecasting is an essential long-term goal in this area, motivated for instance by the needs of modern satellite communication technology. We present a new feature of a recently developed compressible two- and three-dimensional MHD solver, which has been successfully implemented into the parallel AMROC (Adaptive Mesh Refinement in Object-oriented C++) framework with improvements concerning the mesh adaptation criteria based on wavelet techniques. The developments are related to computational efficiency while controlling the precision using dynamically adapted meshes in space-time in a fully parallel context.
Published: 2019

46. Leaf Wax Hydrogen Isotopes as a Hydroclimate Proxy in the Tropical Pacific

Author: Ashley E. Maloney, David Sear, Julian P. Sachs, Sarah Nemiah Ladd, Giorgia Camperio, Matthew Prebble, J. D. Hassall, Daniel B. Nelson, Nathalie Dubois, Peter G. Langdon, Maloney, A. E., 4 School of Oceanography University of Washington Seattle WA USA, Nelson, D. B., 6 Department of Environmental Sciences‐Botany University of Basel Basel Switzerland, Prebble, M., 7 School of Earth and Environment University of Canterbury Christchurch New Zealand, Camperio, G., 1 Swiss Federal Institute of Aquatic Science and Technology (EAWAG) Dept. of Surface Waters—Research and Management Dübendorf Switzerland, Sear, D. A., 9 School of Geography and Environmental Science University of Southampton Southampton UK, Hassall, J. D., Langdon, P. G., Sachs, J. P., and Dubois, N.
Subjects: Atmospheric Science, 010504 meteorology & atmospheric sciences, Hydrogen, Soil Science, chemistry.chemical_element, Aquatic Science, 01 natural sciences, Proxy (climate), 0105 earth and related environmental sciences, Water Science and Technology, Tropical pacific, Wax, Ecology, Isotope, Hydrogen isotope, ddc:551, Paleontology, Forestry, 15. Life on land, 16. Peace & justice, chemistry, 13. Climate action, Environmental chemistry, visual_art, ddc:577.7, visual_art.visual_art_medium, Environmental science, Mangrove
Abstract: Hydrogen isotope ratios of sedimentary leaf waxes (δ2HWax values) are increasingly used to reconstruct past hydroclimate. Here, we add δ2HWax values from 19 lakes and four swamps on 15 tropical Pacific islands to an updated global compilation of published data from surface sediments and soils. Globally, there is a strong positive linear correlation between δ2H values of mean annual precipitation (δ2HP values) and the leaf waxes n‐C29‐alkane (R2 = 0.74, n = 665) and n‐C28‐acid (R2 = 0.74, n = 242). Tropical Pacific δ2HWax values fall within the predicted range of values based on the global calibration, and the largest residuals from the global regression line are no greater than those observed elsewhere, despite large uncertainties in δ2HP values at some Pacific sites. However, tropical Pacific δ2HWax values in isolation are not correlated with estimated δ2HP values from isoscapes or from isotope‐enabled general circulation models. Palynological analyses from these same Pacific sediment samples suggest no systematic relationship between any particular type of pollen distribution and deviations from the global calibration line. Rather, the poor correlations observed in the tropical Pacific are likely a function of the small range of δ2HP values relative to the typical residuals around the global calibration line. Our results suggest that δ2HWax values are currently most suitable for use in detecting large changes in precipitation in the tropical Pacific and elsewhere, but that ample room for improving this threshold exits in both improved understanding of δ2H variability in plants, as well as in precipitation., Plain Language Summary: Past precipitation patterns are difficult to reconstruct, limiting our ability to understand Earth’s climate system. Geochemists reconstruct past precipitation by measuring the amount of heavy hydrogen naturally incorporated into the waxy coating of leaves, which is preserved in mud that accumulates in lakes, soils, and oceans. Heavy hydrogen in leaf waxes is strongly correlated with local precipitation, allowing us to learn about rainfall intensity, temperature, and cloud movement. However, no existing calibration studies include sites from the tropical Pacific, home to the most intense rainfall on the planet and populations that rely on rain for drinking water and farming. We measured heavy hydrogen in leaf waxes from tropical Pacific islands and show that although values are within the global calibration error, no precipitation relationship exists within the region. Plant type distributions do not explain the lack of correlation, which is best attributed to poorly constrained estimates of heavy hydrogen in local rain and the relatively small range of variability within the region. At present, heavy hydrogen from ancient leaf waxes can show large changes in past precipitation, but improved process‐level understanding is needed to use this tool to understand smaller changes in the tropical Pacific and elsewhere., Key Points: Leaf wax 2H/1H ratios are correlated with mean annual precipitation 2H/1H ratios globally, but not in the tropical Pacific. Deviations from the global relationship between precipitation leaf wax 2H/1H ratios cannot be predicted from palynological assemblages. Small range and large uncertainties in estimates of tropical Pacific precipitation 2H/1H ratios likely account for poor correlations., Swiss National Science Foundation, National Science Foundation (NSF) http://dx.doi.org/10.13039/100000001, Natural Environment Research Council (NERC) http://dx.doi.org/10.13039/501100000270, Department of Education and Training, Australian Research Council (ARC) http://dx.doi.org/10.13039/501100000923, http://10.0.15.89/ethz-b-000412154
Published: 2021

47. Trace Element Biogeochemistry in the High‐Latitude North Atlantic Ocean: Seasonal Variations and Volcanic Inputs

Author: Sebastian Steigenberger, Eric P. Achterberg, Jessica K. Klar, Alex R. Baker, C. Mark Moore, Toste Tanhua, Douglas S. Hamilton, Thomas J. Browning, Chris M. Marsay, Stuart C. Painter, Lucia Helena Vieira, Steigenberger, Sebastian, 1 Ocean and Earth Science, National Oceanography Centre Southampton University of Southampton Southampton UK, Klar, Jessica K., 4 Centre de Formation et de Recherche sur les Environnements Méditerranéens (CEFREM), UMR 5110, Université de Perpignan Via Domitia, CNRS Perpignan France, Browning, Thomas J., 2 GEOMAR Helmholtz Centre for Ocean Research Kiel Kiel Germany, Marsay, Chris M., 5 Skidaway Institute of Oceanography University of Georgia Savannah GA USA, Painter, Stuart C., 3 National Oceanography Centre Southampton UK, Vieira, Lúcia H., Baker, Alex R., 6 School of Environmental Sciences University of East Anglia Norwich UK, Hamilton, Douglas S., 7 Department of Earth and Atmospheric Science Cornell University Ithaca NY USA, Tanhua, Toste, and Moore, C. Mark
Subjects: 0106 biological sciences, Atmospheric Science, Global and Planetary Change, geography, 551.9, geography.geographical_feature_category, Vulcanian eruption, 010504 meteorology & atmospheric sciences, Mixed layer, 010604 marine biology & hydrobiology, Trace element, Biogeochemistry, Stratification (water), Atmospheric sciences, 01 natural sciences, Water column, Flux (metallurgy), Volcano, 13. Climate action, Environmental Chemistry, Environmental science, 14. Life underwater, 0105 earth and related environmental sciences, General Environmental Science
Abstract: We present dissolved and total dissolvable trace elements for spring and summer cruises in 2010 in the high‐latitude North Atlantic. Surface and full depth data are provided for Al, Cd, Co, Cu, Mn, Ni, Pb, and Zn in the Iceland and Irminger Basins, and consequences of biological uptake and inputs by the spring Eyjafjallajökull volcanic eruption are assessed. Ash from Eyjafjallajökull resulted in pronounced increases in Al, Mn, and Zn in surface waters in close proximity to Iceland during the eruption, while 3 months later during the summer cruise levels had returned to more typical values for the region. The apparent seasonal removal ratios of surface trace elements were consistent with biological export. Assessment of supply of trace elements to the surface mixed layer for the region, excluding volcanic inputs, indicated that deep winter mixing was the dominant source, with diffusive mixing being a minor source (between 13.5% [dissolved Cd, DCd] and −2.43% [DZn] of deep winter flux), and atmospheric inputs being an important source only for DAl and DZn (DAl up to 42% and DZn up to 4.2% of deep winter + diffusive fluxes) and typically less than 1% for the other elements. Elemental supply ratios to the surface mixed layer through convection were comparable to apparent removal ratios we calculated between spring and summer. Given that deep mixing dominated nutrient and trace element supply to surface waters, predicted increases in water column stratification in this region may reduce supply, with potential consequences for primary production and the biological carbon pump., Key Points: Bio‐essential element concentrations in surface waters decreased from spring to summer with removal ratios reflecting biological uptake. Effects of volcanic inputs from Eyjafjallajökull in spring 2010 were pronounced for Al, Mn, and Zn but returned to typical levels in summer. Deep winter convection dominated trace element supply to surface waters with minor contributions from atmospheric and diffusive mixing., GEOMAR Helmholtz Centre for Ocean Research Kiel http://dx.doi.org/10.13039/501100003153, Natural Environment Research Council http://dx.doi.org/10.13039/501100000270
Published: 2021

48. Biodegradation and flushing of MBT wastes

Author: Powrie, W. [Waste Management Research Group, Faculty of Engineering and the Environment, University of Southampton, Southampton SO17 1BJ (United Kingdom)]
Published: 2013
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49. MEASURING THE ROTATIONAL PERIODS OF ISOLATED MAGNETIC WHITE DWARFS

Author: Knigge, Christian [School of Physics and Astronomy, University of Southampton, Southampton SO17 1BJ (United Kingdom)]
Published: 2013
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50. Leptogenesis with heavy neutrino flavours: from density matrix to Boltzmann equations

Author: Marzola, Luca [School of Physics and Astronomy, University of Southampton, Southampton, SO17 1BJ (United Kingdom)]
Published: 2013
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20,278 results on '"University of Southampton [Southampton]"'

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