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1. Incidence of cancer and overall risk of mortality in individuals treated with raltegravir-based and non-raltegravir-based combination antiretroviral therapy regimens

Author: [ 1 ] UCL, Ctr Clin Res Modelling & Epidemiol, Inst Global Hlth, Res Dept Infect & Populat Hlth,Med Sch, Royal Free Campus,Rowland Hill St, London NW3 2PF, England Show more [ 2 ] Med Univ Innsbruck, Innsbruck, Austria Show more [ 3 ] Charles Univ Prague, Dept Infect & Trop Dis, Fac Med 3, Prague, Czech Republic [ 4 ] Na Bulovce Hosp, Prague, Czech Republic [ 5 ] West Tallinn Cent Hosp, Tallinn, Estonia Show more [ 6 ] Helsinki Univ Hosp, Helsinki, Finland Show more [ 7 ] Univ Nice Sophia Antipolis, LArchet Hosp 1, Nice, France Show more [ 8 ] Univ Copenhagen, Rigshosp, Copenhagen, Denmark Show more [ 9 ] Hippokrateion Hosp, Athens, Greece Show more [ 10 ] Univ Hosp Cologne, Dept Internal Med 1, Cologne, Germany [ 11 ] German Ctr Infect Res DZIF, Partner Site Bonn Cologne, Cologne, Germany Show more [ 12 ] Ichilov Hosp, Tel Aviv, Israel [ 13 ] Kantonsspital St Gallen, St Gallen, Switzerland Show more [ 14 ] Univ Iceland, Sch Hlth Sci, Fac Med, Reykjavik, Iceland Show more [ 15 ] Landspitali Univ Hosp, Reykjavik, Iceland [ 16 ] Ctr HIV AIDS & Infect Dis, Kaliningrad, Russia Show more [ 17 ] Charles Univ Prague, Fac Med 1, Dept Infect & Trop Dis, Prague, Czech Republic Show more [ 18 ] Med Univ Bialystok, Dept Infect Dis & Hepatol, Bialystok, Poland [ 19 ] Ida Viru Cent Hosp, Kohtla Jarve, Estonia [ 20 ] Infectol Ctr Latvia, Riga, Latvia [ 21 ] Dr Victor Babes Hosp, Bucharest, Romania Show more [ 22 ] Hosp JM Ramos Mejia, Buenos Aires, DF, Argentina, Centre for Clinical Research, Modelling and Epidemiology; Research Department of Infection and Population Health; Institute for Global Health; University College London Medical School; Royal Free Campus London UK, Medical University Innsbruck; Innsbruck Austria, Department of Infectious and Tropical Diseases; Third Faculty of Medicine; Charles University and Na Bulovce Hospital; Prague Czech Republic, West-Tallinn Central Hospital; Tallinn Estonia, Helsinki University Hospital; Helsinki Finland, L'Archet 1 Hospital; University of Nice Sophia-Antipolis; Nice France, Rigshospitalet; University of Copenhagen; Copenhagen Denmark, Ippokration General Hospital; Athens Greece, Department of Internal Medicine 1; University Hospital of Cologne; Cologne Germany, Ichilov Hospital; Tel Aviv-Yafo Israel, Kantonsspital St. Gallen; St. Gallen Switzerland, Faculty of Medicine; School of Health Sciences; University of Iceland; Reykjavik, Iceland and Landspitali University Hospital; Reykjavík Iceland, Centre for HIV/AIDS and infectious diseases; Kaliningrad Russian Federation, Department of Infectious and Tropical Diseases; First Faculty of Medicine; Charles University and Na Bulovce Hospital; Prague Czech Republic, Department of Infectious Diseases and Hepatology; Medical University of Bialystok; Bialystok Poland, Ida-Viru Central Hospital; Kohtla-Jarve, Infectology Center of Latvia; Riga Latvia, Dr. Victor Babes Hospital; Bucureşti Romania, Hospital J.M. Ramos Mejia; Buenos Aires Argentina, Cozzi-Lepri, A, Zangerle, R, Machala, L, Zilmer, K, Ristola, M, Pradier, C, Kirk, O, Sambatakou, H, Fätkenheuer, G, Yust, I, Schmid, P, Gottfredsson, M, Khromova, I, Jilich, D, Flisiak, R, Smidt, J, Rozentale, B, Radoi, R, Losso, MH, Lundgren, JD, Mocroft, A, [ 1 ] UCL, Ctr Clin Res Modelling & Epidemiol, Inst Global Hlth, Res Dept Infect & Populat Hlth,Med Sch, Royal Free Campus,Rowland Hill St, London NW3 2PF, England Show more [ 2 ] Med Univ Innsbruck, Innsbruck, Austria Show more [ 3 ] Charles Univ Prague, Dept Infect & Trop Dis, Fac Med 3, Prague, Czech Republic [ 4 ] Na Bulovce Hosp, Prague, Czech Republic [ 5 ] West Tallinn Cent Hosp, Tallinn, Estonia Show more [ 6 ] Helsinki Univ Hosp, Helsinki, Finland Show more [ 7 ] Univ Nice Sophia Antipolis, LArchet Hosp 1, Nice, France Show more [ 8 ] Univ Copenhagen, Rigshosp, Copenhagen, Denmark Show more [ 9 ] Hippokrateion Hosp, Athens, Greece Show more [ 10 ] Univ Hosp Cologne, Dept Internal Med 1, Cologne, Germany [ 11 ] German Ctr Infect Res DZIF, Partner Site Bonn Cologne, Cologne, Germany Show more [ 12 ] Ichilov Hosp, Tel Aviv, Israel [ 13 ] Kantonsspital St Gallen, St Gallen, Switzerland Show more [ 14 ] Univ Iceland, Sch Hlth Sci, Fac Med, Reykjavik, Iceland Show more [ 15 ] Landspitali Univ Hosp, Reykjavik, Iceland [ 16 ] Ctr HIV AIDS & Infect Dis, Kaliningrad, Russia Show more [ 17 ] Charles Univ Prague, Fac Med 1, Dept Infect & Trop Dis, Prague, Czech Republic Show more [ 18 ] Med Univ Bialystok, Dept Infect Dis & Hepatol, Bialystok, Poland [ 19 ] Ida Viru Cent Hosp, Kohtla Jarve, Estonia [ 20 ] Infectol Ctr Latvia, Riga, Latvia [ 21 ] Dr Victor Babes Hosp, Bucharest, Romania Show more [ 22 ] Hosp JM Ramos Mejia, Buenos Aires, DF, Argentina, Centre for Clinical Research, Modelling and Epidemiology; Research Department of Infection and Population Health; Institute for Global Health; University College London Medical School; Royal Free Campus London UK, Medical University Innsbruck; Innsbruck Austria, Department of Infectious and Tropical Diseases; Third Faculty of Medicine; Charles University and Na Bulovce Hospital; Prague Czech Republic, West-Tallinn Central Hospital; Tallinn Estonia, Helsinki University Hospital; Helsinki Finland, L'Archet 1 Hospital; University of Nice Sophia-Antipolis; Nice France, Rigshospitalet; University of Copenhagen; Copenhagen Denmark, Ippokration General Hospital; Athens Greece, Department of Internal Medicine 1; University Hospital of Cologne; Cologne Germany, Ichilov Hospital; Tel Aviv-Yafo Israel, Kantonsspital St. Gallen; St. Gallen Switzerland, Faculty of Medicine; School of Health Sciences; University of Iceland; Reykjavik, Iceland and Landspitali University Hospital; Reykjavík Iceland, Centre for HIV/AIDS and infectious diseases; Kaliningrad Russian Federation, Department of Infectious and Tropical Diseases; First Faculty of Medicine; Charles University and Na Bulovce Hospital; Prague Czech Republic, Department of Infectious Diseases and Hepatology; Medical University of Bialystok; Bialystok Poland, Ida-Viru Central Hospital; Kohtla-Jarve, Infectology Center of Latvia; Riga Latvia, Dr. Victor Babes Hospital; Bucureşti Romania, Hospital J.M. Ramos Mejia; Buenos Aires Argentina, Cozzi-Lepri, A, Zangerle, R, Machala, L, Zilmer, K, Ristola, M, Pradier, C, Kirk, O, Sambatakou, H, Fätkenheuer, G, Yust, I, Schmid, P, Gottfredsson, M, Khromova, I, Jilich, D, Flisiak, R, Smidt, J, Rozentale, B, Radoi, R, Losso, MH, Lundgren, JD, and Mocroft, A
Abstract: To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files, OBJECTIVES: There are currently few data on the long-term risk of cancer and death in individuals taking raltegravir (RAL). The aim of this analysis was to evaluate whether there is evidence for an association. METHODS: The EuroSIDA cohort was divided into three groups: those starting RAL-based combination antiretroviral therapy (cART) on or after 21 December 2007 (RAL); a historical cohort (HIST) of individuals adding a new antiretroviral (ARV) drug (not RAL) to their cART between 1 January 2005 and 20 December 2007, and a concurrent cohort (CONC) of individuals adding a new ARV drug (not RAL) to their cART on or after 21 December 2007. Baseline characteristics were compared using logistic regression. The incidences of newly diagnosed malignancies and death were compared using Poisson regression. RESULTS: The RAL cohort included 1470 individuals [with 4058 person-years of follow-up (PYFU)] compared with 3787 (4472 PYFU) and 4467 (10 691 PYFU) in the HIST and CONC cohorts, respectively. The prevalence of non-AIDS-related malignancies prior to baseline tended to be higher in the RAL cohort vs. the HIST cohort [adjusted odds ratio (aOR) 1.31; 95% confidence interval (CI) 0.95-1.80] and vs. the CONC cohort (aOR 1.89; 95% CI 1.37-2.61). In intention-to-treat (ITT) analysis (events: RAL, 50; HIST, 45; CONC, 127), the incidence of all new malignancies was 1.11 (95% CI 0.84-1.46) per 100 PYFU in the RAL cohort vs. 1.20 (95% CI 0.90-1.61) and 0.83 (95% CI 0.70-0.99) in the HIST and CONC cohorts, respectively. After adjustment, there was no evidence for a difference in the risk of malignancies [adjusted rate ratio (RR) 0.73; 95% CI 0.47-1.14 for RALvs. HIST; RR 0.95; 95% CI 0.65-1.39 for RALvs. CONC] or mortality (adjusted RR 0.87; 95% CI 0.53-1.43 for RALvs. HIST; RR 1.14; 95% CI 0.76-1.72 for RALvs. CONC). CONCLUSIONS: We found no evidence for an oncogenic risk or poorer survival associated with using RAL compared with control groups.

2. Periodic domain patterning by electron beam of proton exchanged waveguides in lithium niobate

Author: De Micheli, M. [Laboratoire de Physique de la Matière Condensée, University of Nice-Sophia Antipolis, 06100 Nice (France)]
Published: 2016
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3. OUTWARD MIGRATION OF JUPITER AND SATURN IN 3:2 OR 2:1 RESONANCE IN RADIATIVE DISKS: IMPLICATIONS FOR THE GRAND TACK AND NICE MODELS

Author: Morbidelli, Alessandro [University of Nice-Sophia Antipolis, CNRS, Observatoire de la côte d'Azur, Laboratoire Lagrange, BP4229, F-06304 NICE Cedex 4 (France)]
Published: 2014
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4. A physical model of the photo- and radiation-induced degradation of ytterbium-doped silica optical fibres

Author: Benabdesselam, Mourad [University of Nice Sophia Antipolis, Laboratoire de Physique de la Matière Condensée (LPMC), CNRS UMR 7336, Parc Valrose, 06108 Nice cedex 2 (France)]
Published: 2014
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5. Simultaneous effects of photo- and radio- darkening in ytterbium-doped aluminosilicate fibers

Author: Benabdesselam, Mourad [University of Nice Sophia Antipolis, Laboratoire de Physique de la Matière Condensée, CNRS UMR 7336, Parc Valrose, 06108 NICE cedex 2 (France)]
Published: 2014
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6. Rotation-dependent catastrophic disruption of gravitational aggregates

Author: Michel, Patrick [Lagrange Laboratory, University of Nice Sophia Antipolis, CNRS, Observatoire de la Côte d'Azur, C.S. 34229, F-06304 Nice Cedex 4 (France)]
Published: 2014
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7. Lager Yeast Design Through Meiotic Segregation of a Saccharomyces cerevisiae × Saccharomyces eubayanus Hybrid

Author: Krogerus, Kristoffer, Magalhães, Frederico, Castillo, Sandra, Peddinti, Gopal, Vidgren, Virve, De Chiara, Matteo, Yue, Jia-xing, Liti, Gianni, Gibson, Brian, School common, CHEM, School services, CHEM, VTT Technical Research Centre of Finland, University of Nice Sophia Antipolis, Aalto-yliopisto, and Aalto University
Subjects: tetraploid, lager yeast, sporulation, brewing, hybrid, S. eubayanus, SDG 3 - Good Health and Well-being, fungi, food and beverages
Abstract: Yeasts in the lager brewing group are closely related and consequently do not exhibit significant genetic variability. Here, an artificial Saccharomyces cerevisiae × Saccharomyces eubayanus tetraploid interspecies hybrid was created by rare mating, and its ability to sporulate and produce viable gametes was exploited to generate phenotypic diversity. Four spore clones obtained from a single ascus were isolated, and their brewing-relevant phenotypes were assessed. These F1 spore clones were found to differ with respect to fermentation performance under lager brewing conditions (15°C, 15 °Plato), production of volatile aroma compounds, flocculation potential and temperature tolerance. One spore clone, selected for its rapid fermentation and acetate ester production was sporulated to produce an F2 generation, again comprised of four spore clones from a single ascus. Again, phenotypic diversity was introduced. In two of these F2 clones, the fermentation performance was maintained and acetate ester production was improved relative to the F1 parent and the original hybrid strain. Strains also performed well in comparison to a commercial lager yeast strain. Spore clones varied in ploidy and chromosome copy numbers, and faster wort fermentation was observed in strains with a higher ploidy. An F2 spore clone was also subjected to 10 consecutive wort fermentations, and single cells were isolated from the resulting yeast slurry. These isolates also exhibited variable fermentation performance and chromosome copy numbers, highlighting the instability of polyploid interspecific hybrids. These results demonstrate the value of this natural approach to increase the phenotypic diversity of lager brewing yeast strains.
Published: 2021
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8. Phytophthora zoospores: From perception of environmental signals to inoculum formation on the host-root surface

Author: Ilaria Bassani, Eric Galiana, Quang D. Tran, Agnès Attard, Marie Larousse, Institut Sophia Agrobiotech (ISA), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Côte d'Azur (UCA), Institut de Physique de Nice (INPHYNI), Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), through the 'Credits Scientifiques Incitatifs' of the University of Nice Sophia-Antipolis, 'Action Recherche' of the INRAE Plant Health and Environment Division, and ANR-15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015)
Subjects: Root surface, Zoospore, [PHYS.PHYS.PHYS-BIO-PH]Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph], lcsh:Biotechnology, Biophysics, Review Article, Biochemistry, 03 medical and health sciences, Motion, Soil, 0302 clinical medicine, Microbial ecology, Structural Biology, lcsh:TP248.13-248.65, Genetics, Host plants, Taxis, 030304 developmental biology, 0303 health sciences, Rhizosphere, biology, Microbiota, 15. Life on land, biology.organism_classification, Phytophthora zoospore, Computer Science Applications, Cell biology, Signaling network, 030220 oncology & carcinogenesis, Perception, Phytophthora, Host-root, [SDV.EE.IEO]Life Sciences [q-bio]/Ecology, environment/Symbiosis, Biotechnology
Abstract: International audience; To explore moist soils and to target host plants, phytopathogenic Phytophthora species utilize the sensory and propulsion capabilities of the biflagellate unicellular zoospores they produce. Zoospore motion and interactions with the microenvironment are of primary importance for Phytophthora physiology. These are also of critical significance for plant pathology in early infection sequential events and their regulation: the directed zoospore migration toward the host, the local aggregation and adhesion at the host penetration site. In the soil, these early events preceding the root colonization are orchestrated by guidance factors, released from the soil particles in water films, or emitted within microbiota and by host plants. This signaling network is perceived by zoospores and results in coordinated behavior and preferential localization in the rhizosphere. Recent computational and structural studies suggest that rhizospheric ion and plant metabolite sensing is a key determinant in driving zoospore motion, orientation and aggregation. To reach their target, zoospores respond to various molecular, chemical and electrical stimuli. However, it is not yet clear how these signals are generated in local soil niches and which gene functions govern the sensing and subsequent responses of zoospores. Here we review studies on the soil, microbial and host-plant factors that drive zoospore motion, as well as the adaptations governing zoospore behavior. We propose several research directions that could be explored to characterize the role of zoospore microbial ecology in disease.
Published: 2020
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9. Impact of Temperature on the Immune Interaction between a Parasitoid Wasp and Drosophila Host Species

Author: Fanny Cavigliasso, Jean-Luc Gatti, Dominique Colinet, Marylène Poirié, Institut Sophia Agrobiotech (ISA), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Côte d'Azur (UCA), University of Nice Sophia Antipolis, French Ministry of Higher Education and Research, ANR-08-BLAN-0231,CLIMEVOL,Climate change and Evolution of host-parasitoid interactions: from molecules to communities(2008), ANR-11-LABX-0028,SIGNALIFE,Réseau d'Innovation sur les Voies de Signalisation en Sciences de la Vie(2011), and ANR-15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015)
Subjects: Drosophila, Science, [SDV]Life Sciences [q-bio], fungi, temperature, encapsulation, venom composition, parasitoid wasp, parasitic success, phenotypic plasticity, Article
Abstract: Simple Summary Global warming affects most species and their interaction s. Insects are ectotherms, meaning their body temperature is affected by the ambient temperature. This is particularly important for koinobiont parasitoids, insects that keep their host insect alive during development of their eggs and larvae, the host eventually being consumed before adult parasitoids emerge. Temperature changes could therefore affect parasitoids directly and/or indirectly through their impact on the host. Here, we tested the effect of temperature on the parasitic success of two parasitoid lines on two host species, and on each partner independently, to determine whether the host immune response and/or the parasitoid venom proteins, injected with the egg to counteract the host immune response, were affected. The host’s immune defense consists of forming a capsule surrounding the parasitoid egg. In half of the interactions tested, the parasitic success increased with temperature. For one, the increase appeared to result solely from an increased capacity of the parasitoid to escape from a capsule, while for the second, it also appeared to involve a decrease in host encapsulation capacity. Finally, we observed a strong change in venom composition depending on the rearing temperature which may partially explain the change in parasitic success. Abstract Temperature is particularly important for ectotherms, including endoparasitoid wasps that develop inside another ectotherm host. In this study, we tested the impact of three temperatures (20 °C, 25 °C and 30 °C) on the host–parasitoid immune interaction using two Drosophila host species (Drosophila melanogaster and D. yakuba) and two parasitoid lines of Leptopilina boulardi. Drosophila’s immune defense against parasitoids consists of the formation of a melanized capsule surrounding the parasitoid egg. To counteract this response, Leptopilina parasitoids rely on the injection of venom during oviposition. Here, we tested the effect of temperature on parasitic success and host encapsulation capacity in response to a parasitoid egg or other foreign body. Increased temperature either promoted or did not affect the parasitic success, depending on the parasitoid–host pairs considered. The mechanisms behind the higher success seemed to vary depending on whether the temperature primarily affected the host immune response or also affected the parasitoid counter-immune response. Next, we tested the effect of parasitoid rearing temperature on its success and venom composition. Venom composition varied strongly with temperature for both parasitoid lines, partially consistent with a change in their parasitic success. Overall, temperature may have a significant impact on the host–parasitoid immune interaction.
Published: 2021
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10. STOCHASTIC GRAVITATIONAL WAVE BACKGROUND FROM COALESCING BINARY BLACK HOLES

Author: Regimbau, T [UMR ARTEMIS, CNRS, University of Nice Sophia-Antipolis, Observatoire de la Cote d'Azur, BP 4229, 06304, Nice Cedex 4 (France)]
Published: 2011
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11. IMPLICATIONS OF A NON-MODAL LINEAR THEORY FOR THE MARGINAL STABILITY STATE AND THE DISSIPATION OF FLUCTUATIONS IN THE SOLAR WIND

Author: Passot, Thierry [University of Nice Sophia Antipolis, CNRS, Observatoire de la Cote d'Azur, B.P. 4229, 06304 Nice Cedex 4 (France)]
Published: 2010
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12. Transient growth in stable collisionless plasma

Author: Passot, Thierry [University of Nice Sophia Antipolis, CNRS, Observatoire de la Cote d'Azur, B.P. 4229, 06304 Nice Cedex 4 (France)]
Published: 2009
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13. Transcriptomic and Ultrastructural Signatures of K+-Induced Aggregation in Phytophthora parasitica Zoospores

Author: Sophie Pagnotta, Xavier Noblin, Nicolas Pons, Franck Panabières, Ilaria Bassani, Eric Galiana, Kevin Lebrigand, Laurent Counillon, François Orange, Corinne Rancurel, Institut Sophia Agrobiotech (ISA), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Côte d'Azur (UCA), Centre Commun de Microscopie Appliquée (CCMA), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Institut de pharmacologie moléculaire et cellulaire (IPMC), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA), Laboratoire de PhysioMédecine Moléculaire (LP2M), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Institut de Physique de Nice (INPHYNI), Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), French government, through 'Credits Scientifiques Incitatifs' of the University of Nice Sophia-Antipolis, French government, through 'Action Recherche' of the INRAE Plant Health and Environment Division, Region Sud -Provence-Alpes-Cote d'Azur, Conseil Departemental des Alpes Maritimes, GIS-IBiSA, ANR-15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015), ANR-10-INTB-0903,COMAGNET,Elaboration de films magnétiques à base cobalt par électrodéposition pulsée sous champ magnétique intense(2010), and ANR-10-INBS-0009,France-Génomique,Organisation et montée en puissance d'une Infrastructure Nationale de Génomique(2010)
Subjects: 0106 biological sciences, 0301 basic medicine, Microbiology (medical), Zoospore, [SDV]Life Sciences [q-bio], Phytophthora zoospores, carbonic anhydrase, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, 01 natural sciences, Microbiology, Article, Transcriptome, 03 medical and health sciences, Virology, [SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB], oomycete, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, lcsh:QH301-705.5, Electroception, Oomycete, biology, Chemistry, potassium, Biofilm, aggregation, biology.organism_classification, Cell biology, 030104 developmental biology, lcsh:Biology (General), [SDE]Environmental Sciences, Ultrastructure, Phytophthora, Intracellular, 010606 plant biology & botany
Abstract: Most pathogenic oomycetes of the genus Phytophthora spread in water films as flagellated zoospores. Zoospores perceive and produce signals attracting other zoospores, resulting in autoaggregation in vitro or biofilm formation on plant surface. The mechanisms underlying intercellular communication and consequent attraction, adhesion and aggregation are largely unknown. In Phytophthora parasitica, the perception of a K+ gradient induces coordinated motion and aggregation. To define cellular and molecular events associated with oomycete aggregation, we combined transcriptomic and ultrastructural analyses. Results indicate involvement of electroception in K+ sensing. They establish that the transcriptome repertoire required for swimming and aggregation is already fully functional at zoospore release. At the time points analyzed, aggregates are mainly constituted of zoospores. They produce vesicular and fibrillary material discharged at cell-to-cell contacts. Consistently, the signature of transcriptome dynamics during transition to aggregates is an upregulation of genes potentially related to vesicular trafficking. Moreover, transcriptomic and functional analyses show a strong enhancement of carbonic anhydrase activity, indicating that pH homeostasis may contribute to aggregation by acting on both zoospore movement and adhesion. This study poses the molecular and cellular bases of aggregative behavior within oomycetes and expands the current knowledge of ion perception-mediated dissemination of propagules in the rhizosphere.
Published: 2020
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14. REGULATION OF MELANOGENESIS BY THE AMINO-ACID TRANSPORTER SLC7A5

Author: Corine Bertolotto, Céline Gaudel, Justine Leclerc, Karine Bille, Robert Ballotti, Frédéric Soysouvanh, François Montcriol, Chrystel Husser, Nunii Laboratoire / Grasse Biotech (Grasse, France), Centre méditerranéen de médecine moléculaire (C3M), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA), This work was supported by grants from INSERM, the University of Nice-Sophia-Antipolis and Nunni laboratoire., BERTOLOTTO-BALLOTTI, BERTOLOTTO-BALLOTTI, Université Nice Sophia Antipolis (... - 2019) (UNS), and COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: 0301 basic medicine, Small interfering RNA, Tyrosinase, Carboxylic Acids, 4-dihydroxyphenylalanine, [SDV.CAN]Life Sciences [q-bio]/Cancer, Dermatology, tyrosinase, Biochemistry, Large Neutral Amino Acid-Transporter 1, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, [SDV.CAN] Life Sciences [q-bio]/Cancer, Cell Line, Tumor, medicine, tyrosine-related protein 1, Animals, Humans, Amino acid transporter, RNA, Small Interfering, Molecular Biology, Melanins, Microphthalmia-Associated Transcription Factor, Gene knockdown, Epidermis (botany), dopachrome tautomerase, Pigmentation, Chemistry, Cell Biology, Norbornanes, Hyperpigmentation, L-3, 3. Good health, 030104 developmental biology, Pyrones, Cell culture, 030220 oncology & carcinogenesis, medicine.symptom, Kojic acid
Abstract: Integration of chromatin immunoprecipitation-sequencing and microarray data enabled us to identify previously unreported MITF-target genes, among which the amino acid transporter SLC7A5 is also included. We reported that small interfering RNA-mediated SLC7A5 knockdown decreased pigmentation in B16F10 cells but neither affected morphology nor dendricity. Treatment with the SLC7A5 inhibitors 2-amino-2-norbornanecarboxylic acid (BCH) or JPH203 also decreased melanin synthesis in B16F10 cells. Our findings indicated that BCH was as potent as reference depigmenting agent, kojic acid, but acted through a different pathway not affecting tyrosinase activity. BCH also decreased pigmentation in human MNT1 melanoma cells or normal human melanocytes. Finally, we tested BCH on a more physiological model, using reconstructed human epidermis and confirmed a strong inhibition of pigmentation, revealing the clinical potential of SLC7A5 inhibition and positioning BCH as a depigmenting agent suitable for cosmetic or dermatological intervention in hyperpigmentation diseases.
Published: 2020
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15. Geometry of Optimal Paths around Focal Singular Surfaces in Differential Games

Author: Bernhard, Pierre [University of Nice-Sophia Antipolis/CNRS I3S, ESSI, 930 Route des Colles, BP 145, 06903 Sophia Antipolis Cedex (France)]
Published: 2005
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16. Opioid-induced constipation

Author: Melchior, Chloé, Chassagne, Philippe, Damon, H., Higuero, T., Siproudhis, Laurent, Vitton, V., Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau (ADEN), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Rouen, Normandie Université (NU), Hospices Civils de Lyon (HCL), Department of Internal Medicine, Archet-1 Hospital, University of Nice-Sophia-Antipolis, 151 Route de Saint Antoine de Ginestière, 06202 Nice, France, Nutrition, Métabolismes et Cancer (NuMeCan), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), CHU Pontchaillou [Rennes], Assistance Publique - Hôpitaux de Marseille (APHM), and Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
Subjects: Management algorithm, Bowel dysfunction, dysfonctionnement intestinal, [SDV]Life Sciences [q-bio], Gastro-intestinal motility, M receptor, constipation induite par les opioïdes, algorithme de prise en charge, Opioid-induced constipation, récepteur μ, motricité intestinale
Abstract: National audience; Opioids use for pain has increased in recent years. Opioid-induced constipation (OIC) is the most common side effect on the gastrointestinal tract. Adverse event could lead to cessation of therapy. Elderly population is extremely exposed to OIC. Gastro-intestinal effect result on the activation of m-receptors widely distributed throughout the gastro-intestinal tract. Opioids effects result on gastrointestinal dysmotility, decrease in chloride and water secretion in the lumen and dysfunction on gastrointestinal sphincters. CIO occurs or worsen after introduction of an opioid and is defined by ROME IV criteria. First of all, other aetiology has to be excluded. A digital rectal examination is strongly recommended to exclude anorectal pathologies. BFI and Bristol Stool Scale are validated questionnaires that can help physicians in clinical management. Management start with prophylactic treatment (fluid intake, activity, high fiber intake). Then management includes standard laxatives, such as osmotic agents and stimulants. In case of inefficacy, peripherally-acting m-opioid receptor antagonist (PAMORAs) could be used. In France, naloxegol and methylnaltrexone could be used.; La prescription d’opioïdes est en augmentation constante dans la prise en charge de la douleur. Un des principaux effets secondaires digestifs est la constipation induite par les opioïdes (CIO). Celle-ci peut être sévère et aboutir à un arrêt du traitement antalgique et à un soulagement inefficace des douleurs, avec un risque majoré chez la personne âgée. Ces effets secondaires digestifs résultent de l’activation des récepteurs μ2 situés sur le tractus gastro-intestinal, à l’origine de troubles de la motricité, de la sécrétion-absorption et de la coordination des sphincters. La CIO est définie selon les critères de Rome IV comme l’apparition ou l’aggravation d’une constipation sous opioïdes. Une autre cause de constipation (médicamenteuse, secondaire à une maladie…) doit avoir été éliminée au préalable. Le Bowel Function Index (BFI) et l’échelle de Bristol sont deux outils simples qui peuvent aider le clinicien dans l’évaluation de la CIO. Le traitement de la CIO repose avant tout sur la prévention avec l’information du patient de la survenue possible d’une constipation sous traitement, et de l’enrichissement en fibres dans l’alimentation avec une hydratation suffisante en particulier chez les personnes âgées. En cas d’échec de ces mesures, elle sera traitée en première intention par des laxatifs « standards » : osmotiques, stimulants puis en association si besoin. En cas de réponse inappropriée aux laxatifs, une classe thérapeutique spécifique (Peripherally-Acting μ-Opioid Receptor Antagonist : PAMORA) peut être proposée en deuxième intention en l’absence de contre-indication. En France, le naloxégol en prise orale et la méthylnaltrexone en injection sous-cutanée sont les deux représentants de cette classe thérapeutique indiqués dans le traitement de la CIO.
Published: 2020
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17. Molecular Weapons Contribute to Intracellular Rhizobia Accommodation Within Legume Host Cell

Author: Laurence Dupont, Geneviève Alloing, Pierre Frendo, Renaud Brouquisse, Alexandre Boscari, Nicolas Pauly, Camille Syska, Marc Bosseno, Institut Sophia Agrobiotech (ISA), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Recherche Agronomique (INRA), Laboratoire des interactions plantes micro-organismes (LIPM), Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Recherche Agronomique, Centre National de la Recherche Scientifique (CNRS), University of Nice-Sophia-Antipolis, ANR-11-PDOC-0028,COPEL,Compréhension et Optimisation de l'Electrogreffage local(2011), and ANR-15-CE20-0005,STAYPINK,Mécanismes contrôlant la transition entre fixation d'azote et sénescence dans les nodosités symbiotiques de légumineuses(2015)
Subjects: 0106 biological sciences, 0301 basic medicine, Root nodule, Mini Review, [SDV]Life Sciences [q-bio], legumes, nitrogen- fixation, nitrogen-fixation, Plant Science, lcsh:Plant culture, 01 natural sciences, Rhizobia, nodule-specific cysteine rich peptides, 03 medical and health sciences, chemistry.chemical_compound, bacteroid, Symbiosis, nitric oxide, lcsh:SB1-1110, Reactive nitrogen species, reactive oxygen species, Innate immune system, biology, food and beverages, Nitrogenase, biology.organism_classification, toxin-antitoxin, symbiosis, nodule- specific cysteine rich peptides, Cell biology, 030104 developmental biology, chemistry, toxin–antitoxin, Nitrogen fixation, Bacteria, 010606 plant biology & botany
Abstract: The interaction between legumes and bacteria of rhizobia type results in a beneficial symbiotic relationship characterized by the formation of new root organs, called nodules. Within these nodules the bacteria, released in plant cells, differentiate into bacteroids and fix atmospheric nitrogen through the nitrogenase activity. This mutualistic interaction has evolved sophisticated signaling networks to allow rhizobia entry, colonization, bacteroid differentiation and persistence in nodules. Nodule cysteine rich (NCR) peptides, reactive oxygen species (ROS), reactive nitrogen species (RNS), and toxin-antitoxin (TA) modules produced by the host plants or bacterial microsymbionts have a major role in the control of the symbiotic interaction. These molecules described as weapons in pathogenic interactions have evolved to participate to the intracellular bacteroid accommodation by escaping control of plant innate immunity and adapt the functioning of the nitrogen-fixation to environmental signalling cues.
Published: 2019
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18. Multifaceted roles of nitric oxide in plants

Author: Renaud Brouquisse, Institut Sophia Agrobiotech (ISA), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Côte d'Azur (UCA), Institut National de la Recherche Agronomique, Centre National de la Recherche Scientifique (CNRS), and University of Nice-Sophia-Antipolis
Subjects: 0106 biological sciences, 0303 health sciences, Physiology, [SDV]Life Sciences [q-bio], Plant Science, Plants, Nitric Oxide, Reactive Nitrogen Species, 01 natural sciences, Redox, Nitric oxide, Fight-or-flight response, 03 medical and health sciences, Plant development, chemistry.chemical_compound, chemistry, Environmental chemistry, Reactive nitrogen species, 030304 developmental biology, 010606 plant biology & botany
Abstract: Nitric oxide (NO) is a reactive free radical gaseous molecule with a broad spectrum of regulatory functions in plant growth and development, and in response to abiotic and biotic (pathogenic and symbiotic interactions) factors. It is known to act either as a signaling molecule (mainly via redox-dependent post-translational modifications), a metabolic intermediate, or a toxic oxidative by-product. The reviews and research papers in this special issue summarize recent advances in our knowledge of plant NO production and degradation pathways, examine NO signaling mechanisms, and highlight its crosstalk with reactive oxygen species, hydrogen sulfide, and hormone-signaling processes for regulation of plant growth and responses to external stimuli.
Published: 2019
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19. Nitric oxide signaling, metabolism and toxicity in nitrogen-fixing symbiosis

Author: Pierre Frendo, Renaud Brouquisse, Alexandre Boscari, Antoine Berger, Institut Sophia Agrobiotech (ISA), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Recherche Agronomique (INRA), Institut National de la Recherche Agronomique', the 'Centre National de la Recherche Scientifique, and University of Nice-Sophia-Antipolis
Subjects: 0106 biological sciences, Physiology, legumes, [SDV]Life Sciences [q-bio], phytoglobin, Plant Science, Bacterial Physiological Phenomena, 01 natural sciences, Nitric oxide, Rhizobia, nitrogen-fixing symbiosis, 03 medical and health sciences, chemistry.chemical_compound, rhizobium, Symbiosis, nitric oxide, Nitrogen Fixation, Hypoxia, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, biology, Bacteria, Nitrogenase, Metabolism, Plants, biology.organism_classification, Cell biology, Enzyme, chemistry, [SDE]Environmental Sciences, Nitrogen fixation, Rhizobium, Root Nodules, Plant, 010606 plant biology & botany, Signal Transduction
Abstract: Interactions between legumes and rhizobia lead to the establishment of a symbiotic relationship characterized by the formation of a new organ, the nodule, which facilitates the fixation of atmospheric nitrogen (N2) by nitrogenase through the creation of a hypoxic environment. Significant amounts of nitric oxide (NO) accumulate at different stages of nodule development, suggesting that NO performs specific signaling and/or metabolic functions during symbiosis. NO, which regulates nodule gene expression, accumulates to high levels in hypoxic nodules. NO accumulation is considered to assist energy metabolism within the hypoxic environment of the nodule via a phytoglobin–NO-mediated respiration process. NO is a potent inhibitor of the activity of nitrogenase and other plant and bacterial enzymes, acting as a developmental signal in the induction of nodule senescence. Hence, key questions concern the relative importance of the signaling and metabolic functions of NO versus its toxic action and how NO levels are regulated to be compatible with nitrogen fixation functions. This review analyses these paradoxical roles of NO at various stages of symbiosis, and highlights the role of plant phytoglobins and bacterial hemoproteins in the control of NO accumulation.
Published: 2019
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20. Guidance of zoospores by potassium gradient sensing mediates aggregation

Author: Xavier Noblin, Catherine Etienne, Eric Galiana, Céline Cohen, Philippe Thomen, Institut Sophia Agrobiotech [Sophia Antipolis] (ISA), Institut National de la Recherche Agronomique (INRA)-Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Université Côte d’Azur, CNRS, INPHYNI, Nice, France, UMR 1355 ISA Institut Sophia Agrobiotech, Université de Nice Sophia-Antipolis (UNSA), Institut Sophia Agrobiotech (ISA), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Recherche Agronomique (INRA), French government, through the UCAJEDI Investments in the Future project managed by the National Research Agency (ANR) under reference number ANR-15-IDEX-01, through the 'Credits Scientifiques Incitatifs' of the University of Nice Sophia-Antipolis and the 'Action Recherche' of the INRA Plant Health and Environment Division., Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Côte d'Azur (UCA), Institut de Physique de Nice (INPHYNI), Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), ANR-15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015), and Galiana, Eric
Subjects: Phytophthora, Zoospore, Potassium, Population, Biomedical Engineering, Biophysics, chemistry.chemical_element, Bioengineering, Biochemistry, Suspension (chemistry), Biomaterials, 03 medical and health sciences, zoospore, Live cell imaging, aggregation, bioconvection, negative chemotaxis, [PHYS.COND]Physics [physics]/Condensed Matter [cond-mat], education, [SDV.MP.MYC]Life Sciences [q-bio]/Microbiology and Parasitology/Mycology, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, 0303 health sciences, education.field_of_study, Plant roots, Negative chemotaxis, biology, 030306 microbiology, Chemistry, Chemotaxis, Life Sciences–Physics interface, Spores, Fungal, biology.organism_classification, Plume, [PHYS.COND.CM-SCM]Physics [physics]/Condensed Matter [cond-mat]/Soft Condensed Matter [cond-mat.soft], Biotechnology
Abstract: Biflagellate zoospores of some phytopathogenic Phytophthora species spontaneously aggregate within few minutes in suspension. Depending on species auto-aggregate formation results from bioconvection or from a sequence bioconvection-positive chemotaxis. In this study, we show that P. parasitica zoospores may form aggregates upon application of a K+ gradient in particular geometric arrangements. Based on the use of macro- and microfluidic devices, in addition to time-lapse live imaging both in the vertical and horizontal planes, we defined (i) the spatiotemporal and concentration scale evolution within the gradient in correlation with (ii) cell distribution and (iii) metrics of zoospore motion (velocity, trajectory). The results indicated that K+-induced aggregates result from a single bi-phasic temporal sequence involving negative chemotaxis and then bioconvection in a K+ gradient concentration scale [0-17 mM]. Each K+-sensing cell undergoes a forward-to-backward movement within a threshold range of 1-4mM, thereby forming progressively a swarm. Once a critical population density is achieved zoospores form a plume which undergoes a downward migration leading to aggregate formation on the support surface. We discuss putative sources for K+ gradient generation in natural environment (zoospore population, microbiota, plant roots, soil particles), and implication for events preceding inoculum formation on host plant.
Published: 2019
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21. The classification societies, an obstacle or an accelerator to international maritime safety?

Author: Raphaël Lissillour, Dominique Bonet Fernandez, François FULCONIS, IPAG Lab (IPAG Lab), IPAG Business School, Centre de Recherche sur le Transport et la Logistique (CRET-LOG), Aix Marseille Université (AMU), Laboratoire Biens, Normes, Contrats (LBNC), Avignon Université (AU), and IPAG Business School, South Champagne Business School, Telfer School of Management - University of Ottawa, and University of Nice Sophia Antipolis (UNS)
Subjects: Théorie de la pratique, Maritime safety, Bourdieu, Sociétés de classification, Theory of practice, Sécurité maritime, [SHS.GESTION]Humanities and Social Sciences/Business administration, Classification societies
Abstract: International audience; The high growth of maritime traffic worldwide is not without causing incidents. The industrial shipping chain links many different actors, including at least five main actors who may play a role in maritime safety matters: ship-owners, shipyards, charterers, insurance underwriters, and classification societies. In a complex chain of operations, what actor is preponderant in the management of maritime safety? Classification societies seem to play a major role in the management and governance of maritime safety. Nevertheless, many maritime casualties are still occurring every year. In this context, our research questions are twofold: are the classification societies a facilitator or a hindrance to maritime safety? What theoretical perspective can contribute to a better understanding of this inter-organizational issue linking classification societies to the maritime logistic ecosystem? We have selected Bourdieu’s theory of practice to provide deep sociological insights into the stakeholders’ interests, their source of power in the field of maritime safety, and how the dominion of the classification societies is sustained and fueled by the practices of each actor. Based on a qualitative field study with major actors of the industrial shipping chain, our results show the centrality of the classification societies. They benefit from major position due to their high endowment in the forms of capital that are predominant in the field, in particular symbolic, social, informational and economic capital.; La forte croissance du trafic maritime mondial n'est pas sans causer d'incidents. La chaîne industrielle de la navigation relie de nombreux acteurs, dont au moins cinq acteurs principaux pouvant jouer un rôle en matière de sécurité maritime: armateurs, chantiers navals, affréteurs, souscripteurs d’assurance et sociétés de classification. Dans une chaîne d'opérations complexe, quel est l’acteur prépondérant dans la gestion de la sécurité maritime? Les sociétés de classification semblent jouer un rôle majeur dans la gestion et la gouvernance de la sécurité maritime. Néanmoins, de nombreux incidents maritimes continuent de se produire chaque année. Dans ce contexte, nos questions de recherche sont: les sociétés de classification sont-elles un facilitateur ou un obstacle à la sécurité maritime? Quelle perspective théorique peut contribuer à une meilleure compréhension de cet enjeu inter-organisationnel liant les sociétés de classification à l’écosystème logistique maritime? Nous avons choisi la théorie de la pratique de Bourdieu pour fournir une approche sociologique approfondie sur les intérêts des parties prenantes, leur source de pouvoir dans le domaine de la sécurité maritime et sur la manière dont la domination des sociétés de classification est soutenue et alimentée par les pratiques de chaque acteur. Basés sur une étude de terrain qualitative auprès d’acteurs majeurs de la chaîne industrielle de navigation, nos résultats montrent la centralité des sociétés de classification. Celles-ci bénéficient d’une position dominante en raison de leur forte dotation en capital prédominante dans le domaine, en particulier en capital symbolique, social, informationnel et économique.
Published: 2019

22. EXPONENTIAL INEQUALITY FOR CHAOS BASED ON SAMPLING WITHOUT REPLACEMENT

Author: Patricia Reynaud-Bouret, P Hodara, Institut National de la Recherche Agronomique (INRA), Laboratoire Jean Alexandre Dieudonné (JAD), Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), ANR: UCA Jedi,ANR-15-IDEX-01, Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS), ANR-15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015), ANR-19-P3IA-0002,3IA@cote d'azur,3IA Côte d'Azur(2019), Mathématiques et Informatique Appliquées du Génome à l'Environnement [Jouy-En-Josas] (MaIAGE), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), FAPESP project Research, Innovation and Dissemination Center for Neuromathematics [2013/07699-0, 2016/17655-8], French government [ANR-15-IDEX-01], structuring program C@UCA of University Cote d'Azur, and University of Nice Sophia-Antipolis
Subjects: Statistics and Probability, Inequality, media_common.quotation_subject, [SDV]Life Sciences [q-bio], Mathematics - Statistics Theory, Statistics Theory (math.ST), 01 natural sciences, 010104 statistics & probability, [MATH.MATH-ST]Mathematics [math]/Statistics [math.ST], FOS: Mathematics, Applied mathematics, [INFO]Computer Science [cs], 0101 mathematics, Concentration inequality, [MATH]Mathematics [math], Randomness, Mathematics, media_common, 010102 general mathematics, Probability (math.PR), [STAT.TH]Statistics [stat]/Statistics Theory [stat.TH], Simple random sample, Exponential function, CHAOS (operating system), [MATH.MATH-PR]Mathematics [math]/Probability [math.PR], Order (business), Chaos, U-statistics, Statistics, Probability and Uncertainty, Mathematics - Probability
Abstract: International audience; We are interested in the behavior of particular functionals, in a framework where the only source of randomness is a sampling without replacement. More precisely the aim of this short note is to prove an exponential concentration inequality for special U-statistics of order 2, that can be seen as chaos. (C) 2018 Published by Elsevier B.V.
Published: 2019
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23. Sub-national context and radical right support in Europe: Policy Brief

Author: Evans, Jocelyn, Norman, Paul, Gould, Myles, Hood, Nicholas, Ivaldi, Gilles, Dutozia, Jérôme, Arzheimer, Kai, Berning, Carl, van der Brug, Wouter, de Lange, Sarah, van der Meer, Tom, Harteveld, Eelco, University of Leeds, Unite de recherche migrations et sociétés (URMIS), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Paris Diderot - Paris 7 (UPD7)-Institut de recherche pour le développement [IRD] : UR205-Centre National de la Recherche Scientifique (CNRS), Johannes Gutenberg - Universität Mainz (JGU), Universiteit van Amsterdam (UvA), University of Amsterdam [Amsterdam] (UvA), University of Nice - Sophia Antipolis, France, Université Nice Sophia Antipolis (1965 - 2019) (UNS), Johannes Gutenberg - Universität Mainz = Johannes Gutenberg University (JGU), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Université Paris Diderot - Paris 7 (UPD7)-Institut de recherche pour le développement [IRD] : UR205-Centre National de la Recherche Scientifique (CNRS), Johannes Gutenberg - University of Mainz (JGU), Challenges to Democratic Representation (AISSR, FMG), Political Sociology (AISSR, FMG), and FMG
Subjects: Europe, Populist Radcal right Parties, Political Behavior, Citizen's Environement, [SHS.SCIPO]Humanities and Social Sciences/Political science
Abstract: The SCoRE project focuses onexplaining regional differences in support for populist radical right parties. More specifically, it examines how developments in citizens’ immediate environment - what one would commonly call the ‘neighbourhood’ or ‘community’ level - affect their attitudes towards immigrants and political elites and thereby their support for populist radical right parties. The project focuses on the impact of developments that manifest themselves very differently in urban and rural areas, such as the settlement of immigrants in cities and the exodus of young citizens and the decline in public services in rural areas. The project is comparative in nature and looks at the impact of these developments in four countries:United Kingdom(excluding Northern Ireland and Scotland), France, Germany, and the Netherlands. These countries are characterized by different historical trajectories with respect to, for example, urban-rural relations, immigration patterns, and support for populist radical right parties.In the countries under study, large-scale representative surveys have been conducted, with proper representation of citizens with different background characteristics (e.g. also including the less educated and politically alienated) and from different kinds of municipalities and neighbourhoods. The survey data, consisting of the same core set of questions in each country, have been connectedto statistical data on developments at the community level, embedding the surveyed respondents in the characteristics of their neighbourhood.On the basis of these data we have investigated how citizens’ attitudes – especially nativist attitudes (the feeling that countries should be populated primarily by natives, and that non-natives are a vital threat to the nation-state) and political discontent (the feeling that political elites are not taking the people and their interests seriously) – are influenced by their daily environment (the environment in which they live), as well as by their broader environment (the environment that they might visit on a regular basis, or read about in the local media). Hence, the impact of developments in the surrounding neighbourhoods on citizens’ opinions and political behaviour has also been examined.
Published: 2019

24. Finishing and polishing effects of multiblade burs on the surface texture of 5 resin composites: microhardness and roughness testing

Author: Etienne Medioni, Nathalie Brulat-Bouchard, Elodie Ehrmann, Microbiologie Orale, Immunothérapie et Santé (MICORALIS), Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Centre de Mise en Forme des Matériaux (CEMEF), MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), and Department of Restorative Dentistry and Endodontics, Faculty of Dentistry, University of Nice Sophia Antipolis
Subjects: Materials science, Finishing, Scanning electron microscope, Polishing, Composite resins, 02 engineering and technology, Surface finish, Indentation hardness, 03 medical and health sciences, 0302 clinical medicine, Surface roughness, Composite material, [SDV.IB.BIO]Life Sciences [q-bio]/Bioengineering/Biomaterials, Dental polishing, ComputingMilieux_MISCELLANEOUS, Nanocomposite, Surface hardness, 030206 dentistry, General Medicine, Multiblade burs, 021001 nanoscience & nanotechnology, Hardness, Profilometer, 0210 nano-technology, Research Article
Abstract: Objectives The aim of this in vitro study was to test the effect of 2 finishing-polishing sequences (QB, combining a 12/15-fluted finishing bur and an EVO-Light polisher; QWB, adding a 30-fluted polishing bur after the 12/15-fluted finishing bur used in the QB sequence) on 5 nanotech-based resin composites (Filtek Z500, Ceram X Mono, Ceram X Duo, Tetric Evoceram, and Tetric Evoceram Bulk Fill) by comparing their final surface roughness and hardness values to those of a Mylar strip control group (MS). Materials and Methods Twelve specimens of each nanocomposite were prepared in Teflon moulds. The surface of each resin composite was finished with QB (5 samples), QWB (5 samples), or MS (2 samples), and then evaluated (60 samples). Roughness was analysed with an optical profilometer, microhardness was tested with a Vickers indenter, and the surfaces were examined by optical and scanning electron microscopy. Data were analysed using the Kruskal-Wallis test (p < 0.05) followed by the Dunn test. Results For the hardness and roughness of nanocomposite resin, the QWB sequence was significantly more effective than QB (p < 0.05). The Filtek Z500 showed significantly harder surfaces regardless of the finishing-polishing sequence (p < 0.05). Conclusions QWB yielded the best values of surface roughness and hardness. The hardness and roughness of the 5 nanocomposites presented less significant differences when QWB was used.
Published: 2019
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25. Redox regulation of differentiation in symbiotic nitrogen fixation

Author: Carolina Werner Cw Ribeiro, Pierre Frendo, Geneviève Alloing, Karine Mandon, Institut Sophia Agrobiotech (ISA), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Recherche Agronomique (INRA), Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (Brasil), Institut National de la Recherche Agronomique, Centre National de la Recherche Scientifique, University of Nice - Sophia Antipolis, and French Government (National Research Agency, ANR) [ANR-11-LABX-0028-01]
Subjects: Root nodule, [SDV]Life Sciences [q-bio], Biophysics, Nitrogen-fixing symbiosis, Biology, Biochemistry, (Homo)glutathione, 03 medical and health sciences, chemistry.chemical_compound, Symbiosis, Nitrogen Fixation, Botany, Molecular Biology, Reactive nitrogen species, 030304 developmental biology, 2. Zero hunger, 0303 health sciences, 030306 microbiology, food and beverages, Nitrogenase, Cell Differentiation, Fabaceae, biology.organism_classification, Plant cell, Reactive Nitrogen Species, Cell biology, chemistry, Redox regulation, [SDE]Environmental Sciences, Host-Pathogen Interactions, Nitrogen fixation, Rhizobium, Reactive Oxygen Species, Root Nodules, Plant, Oxidation-Reduction, Bacteria, Sinorhizobium meliloti
Abstract: International audience; Background: Nitrogen-fixing symbiosis between Rhizobium bacteria and legumes leads to the formation of a new organ, the root nodule. The development of the nodule requires the differentiation of plant root cells to welcome the endosymbiotic bacterial partner. This development includes the formation of an efficient vascular tissue which allows metabolic exchanges between the root and the nodule, the formation of a barrier to oxygen diffusion necessary for the bacterial nitrogenase activity and the enlargement of cells in the infection zone to support the large bacterial population. Inside the plant cell, the bacteria differentiate into bacteroids which are able to reduce atmospheric nitrogen to ammonia needed for plant growth in exchange for carbon sources. Nodule functioning requires a tight regulation of the development of plant cells and bacteria. Scope of the review: Nodule functioning requires a tight regulation of the development of plant cells and bacteria. The importance of redox control in nodule development and N-fixation is discussed in this review. The involvement of reactive oxygen and nitrogen species and the importance of the antioxidant defense are analyzed. Major conclusions: Plant differentiation and bacterial differentiation are controlled by reactive oxygen and nitrogen species, enzymes involved in the antioxidant defense and antioxidant compounds. General significance: The establishment and functioning of nitrogen-fixing symbiosis involve a redox control important for both the plant-bacteria crosstalk and the consideration of environmental parameters. This article is part of a Special Issue entitled Redox regulation of differentiation and de-differentiation.
Published: 2015
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26. One-Year Outcome for Congenital Diaphragmatic Hernia: Results From the French National Register

Author: Charles Muszynski, Jean Breaud, Quentin Ballouhey, Elsa Kermorvant, Sylvain Samperiz, Valérie Datin-Dorrière, Laurent Storme, Anne Schneider, Thierry Blanc, Alexis Arnaud, Odile Pidoux, François Barrière, Norbert Winer, Julia Boubnova, Elisabeth Carricaburu, Fabrice Michel, Armelle Garenne, Nicolas Berte, Frederic Lavrand, Yann Chaussy, Aurélien Binet, Amélie Desrumaux, Sébastien Blanc, Anderson Loundou, Guillaume Levard, Virginie Fouquet, Marie-Odile Marcoux, Isabelle Rayet, Urgences pédiatriques [Hôpital de la Timone - APHM], Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Centre d'études et de recherche sur les services de santé et la qualité de vie (CEReSS), Aix Marseille Université (AMU), Hôpital Bicètre, Service de chirurgie pédiatrique, Hôpital Bicêtre, unité de soins intensifs néonatals, Université Paris Descartes - Paris 5 (UPD5)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Unité de soins intensifs néonatals, Hôpital Femme Mère Enfant [CHU - HCL] (HFME), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Service de chirurgie pédiatrique, AP-HP Hôpital universitaire Robert-Debré [Paris], unité de soins intensifs pédiatriques, hôpital couple-enfant [CHU Grenoble Alpes], département de néonatologie [Centre Hospitalier Régional Universitaire [Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Service de chirurgie pédiatrique [Rennes] = Paediatric / Pediatric surgery [Rennes], CHU Pontchaillou [Rennes], Département de chriurgie, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Service de pédiatrie néonatale et réanimation - neuropédiatrie [CHU Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Hôpital Charles Nicolle [Rouen]-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Service de chirurgie pédiatrique [CHU Bordeaux], Hôpital des Enfants - Groupe hospitalier Pellegrin - CHU de Bordeaux, service de chirurgie pédiatrique, Centre hospitalier universitaire de Poitiers (CHU Poitiers), Hôpital Nord (Saint Etienne), Centre hospitalier Félix-Guyon [Saint-Denis, La Réunion], Département de chirurgie pédiatrique, Hôpital de Hautepierre [Strasbourg], Unité de soins intensifs néonatals [Hôpital des Enfants, Toulouse], Hôpital des Enfants, CHU Toulouse [Toulouse]-CHU Toulouse [Toulouse], Département d'obstétrique et Gynécologie [Hôtel-Dieu, Nantes], Hôtel-Dieu de Nantes, Département de chirurgie pédiatrique [Hôspital Universitaire Jean Minjoz , Besançon], Hôpital JeanMinjoz, Hôpital Côte de Nacre [CHU Caen], CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Service de chirurgie pédiatrique viscérale, orthopédique et plastique [CHU Limoges], CHU Limoges, Département de chirurgie pédiatrique [Clocheville University Hospital, Tours], CHRU Clocheville, Département d'obstétrique Gynécologie [, Amiens University Hospital, Amiens], CHU Amiens-Picardie, Département de chirurgie pédiatrique [Nice Pediatric Hospital, University of Nice-Sophia Antipolis, Nice], Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre Hospitalier Universitaire de Nice (CHU de Nice), CHRU de Brest - Département de Pédiatrie (CHU BREST Pédiatrie), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Service de médecine néonatale [Lille University Hospital, Lille], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Chirurgie orthopédique et pédiatrique [Hôpital de la Timone - APHM], Groupe Hospitalier Sud, Service de pédiatrie néonatale et réanimation - neuropédiatrie [Rouen], Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Hôpital Charles Nicolle [Rouen], Hôpital Universitaire d'Amiens, Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre Hospitalier Universitaire de Nice (CHU de Nice), Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Hôpital Charles Nicolle [Rouen], Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), Service Réanimation néonatale et pédiatrique spécialisée [CHU Toulouse], Pôle Enfants [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre Hospitalier Universitaire de Nice (CHU Nice), Service de chirurgie pédiatrique [Rennes], Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-CHU Pontchaillou [Rennes], Hôpital Charles Nicolle [Rouen]-CHU Rouen, and COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Centre Hospitalier Universitaire de Nice (CHU de Nice)
Subjects: Male, Pediatrics, medicine.medical_specialty, Adverse outcomes, education, congenital diaphragmatic hernia, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, Risk Factors, 030225 pediatrics, Prenatal Diagnosis, Infant Mortality, medicine, Hospital discharge, Humans, 030212 general & internal medicine, Fetal loss, Prospective Studies, Registries, health care economics and organizations, business.industry, Mortality rate, Persistent pulmonary hypertension, Infant, Newborn, Congenital diaphragmatic hernia, Infant, Prenatal Care, medicine.disease, mortality, 3. Good health, Survival Rate, Treatment Outcome, Prenatal risk, Pediatrics, Perinatology and Child Health, outcome, Female, France, prognosis, business, Hernias, Diaphragmatic, Congenital, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: To evaluate the status of congenital diaphragmatic hernia (CDH) management in France and to assess predictors of adverse outcomes.We reviewed the first-year outcome of all cases of CDH reported to the French National Register in 2011.A total of 158 cases were included. Of these, 83% (131) were prenatally diagnosed, with a mortality rate of 39% (44 of 112) for live born infants with a known outcome at hospital discharge. Mortality increased to 47% (60 of 128) including those with termination of pregnancy and fetal loss. This contrasts with the 7% (2 of 27) mortality rate of the patients diagnosed postnatally (P = .002). Mortality worsened with 1 prenatal marker of CDH severity (OR 3.38 [1.30-8.83] P = .013) and worsened further with 2 markers (OR 20.64 [5.29-80.62] P .001). Classic postnatal risk factors of mortality such as side of hernia (nonleft P = .001), prematurity (P .001), low birth weight (P = .002), and size of the defect (P .001) were confirmed. Of the 141 live births (114 prenatal and 27 postnatal diagnosis) with known outcomes, 93 (67%) survived to hospital discharge, 68 (60%) with a prenatal diagnosis and 25 (93%) with a postnatal diagnosis. The median time to hospital discharge was 34 days (IQR, 19.25-62). Of these survivors, 71 (76%) were followed up for 1 year.Despite advances in management of CDH, mortality was high and associated with prenatal risk factors. Postnatally, severe persistent pulmonary hypertension was difficult to predict and presented persistent challenges in management.
Published: 2018
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27. Combination of blood and biphasic calcium phosphate microparticles for the reconstruction of large bone defects in dog: A pilot study

Author: Balaguer, Thierry, Fellah, Borhane H., Boukhechba, Florian, Traverson, Marine, Mouska, Xavier, Ambrosetti, Damien, Dadone, Berengere, Michiels, Jean-Francois, Amri, Ez-Zoubir, Trojani, Christophe, Bouler, Jean-Michel, Gauthier, Olivier, Rochet, Nathalie, Génétique, physiopathologie et ingénierie du tissu osseux (GéPITOS), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA), Graftys SARL, Institut de pharmacologie moléculaire et cellulaire (IPMC), Hôpital Pasteur [Nice] (CHU), Université Nice Sophia Antipolis - Faculté de Médecine (UNS UFR Médecine), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Institute of Developmental Biology and Cancer (IBDC), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Service de Chirurgie Orthopédique et Chirurgie du Sport, Hôpital de L'Archet, University of Nice-Sophia Antipolis, Chimie Et Interdisciplinarité : Synthèse, Analyse, Modélisation (CEISAM), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Dauphine Recherches en Management (DRM), Université Paris Dauphine-PSL, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), and Génétique et pathologies moléculaires (GPM)
Subjects: [CHIM]Chemical Sciences, sense organs
Abstract: We previously reported that biphasic calcium phosphate (BCP) microparticles embedded in a blood clot induces ectopic bone formation in mice and repairs a critical femoral defect in rat. The present pilot study aimed to evaluate in dog and in two models of large defects the efficacy of this composite named blood for reconstruction of bone (BRB). We show here that BRB is a cohesive biomaterial easy to prepare from dog autologous blood and to mold to fill large bone defects. First in a model of cylindrical femoral condyle defect, the BRB was compared with BCP particles alone. After 8 weeks, this revealed that the amount of mature bone was slightly and significantly higher with BRB than with BCP particles. Second, in a model consisting in a 2 cm-long critical interruptive defect of the ulna, the BRB was compared with autologous bone. After 6 months, we observed that implantation of BRB can induce the complete reconstruction of the defect and that newly formed bone exhibits high regenerative potential. Comparison with the results obtained with autologous bone grafting strongly suggests that the BRB might be an efficient biomaterial to repair large bone defects, as an alternative or in addition to autologous bone. (c) 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 1842-1850, 2018.
Published: 2018
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28. In situ hybridization (ISH) in preparasitic and parasitic stages of the plant-parasitic nematode Meloidogyne spp

Author: Marie-Noëlle Rosso, Maëlle Jaouannet, Stéphanie Jaubert-Possamai, C. Nguyen, Michaël Quentin, Bruno Favery, Institut Sophia Agrobiotech [Sophia Antipolis] (ISA), Institut National de la Recherche Agronomique (INRA)-Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), UMR 1355 ISA, Institut National de la Recherche Agronomique (INRA), Université de Nice Sophia-Antipolis (UNSA), Biodiversité et Biotechnologie Fongiques (BBF), Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM), INRA, CNRS, University of Nice Sophia Antipolis, the Region Provence-Alpes-Côte d’Azur, the French Government, the European Union and NATO Collaborative Research Grant. C-N.N. was supported by USTH fellowships, 911-USTH program, from the Ministry of Education and Training of The Socialist Republic of Vietnam., Institut Sophia Agrobiotech (ISA), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Recherche Agronomique (INRA), Aix Marseille Université (AMU)-Institut National de la Recherche Agronomique (INRA)-École Centrale de Marseille (ECM), École Centrale de Marseille (ECM)-Aix Marseille Université (AMU)-Institut National de la Recherche Agronomique (INRA), Favery, Bruno, Institut National de la Recherche Agronomique (INRA)-Université Nice Sophia Antipolis (1965 - 2019) (UNS), and COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)
Subjects: 0106 biological sciences, 0301 basic medicine, Strategy and Management, [SDV]Life Sciences [q-bio], Gene expression pattern, Plant pathogen, Preparasitic and parasitic stages, mRNAs, In situ hybridization, Biology, 01 natural sciences, Industrial and Manufacturing Engineering, 03 medical and health sciences, chemistry.chemical_compound, Dig, Methods Article, Parasite hosting, Digoxigenin, Gene, Mechanical Engineering, Hybridization probe, Metals and Alloys, RNA, virus diseases, biology.organism_classification, Molecular biology, 030104 developmental biology, Nematode, chemistry, 010606 plant biology & botany
Abstract: The spatio-temporal expression pattern of a gene provides important indications to better understand its biological function. In situ hybridization (ISH) uses a labeled complementary single-stranded RNA or DNA probe to localize gene transcripts in a whole organism, a whole organ or a section of tissue. We adapted the ISH technique to the plant parasite Meloidogyne spp. (root-knot nematode) to visualize RNAs both in free-living preparasitic juveniles and in parasitic stages settled in the plant tissues. We describe each step of the probe synthesis, digoxigenin (DIG) labeling, nematode extraction from plant tissue, and ISH procedure.
Published: 2018
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29. Effects of high- versus moderate-intensity training on neuroplasticity and functional recovery after focal ischemia

Author: Annabelle Constans, Caroline Pin-Barre, Jérôme Laurin, Christophe Pellegrino, Jeanick Brisswalter, Laboratoire Motricité Humaine Expertise Sport Santé ( LAMHESS ), Université Nice Sophia Antipolis ( UNS ), Université Côte d'Azur ( UCA ) -Université Côte d'Azur ( UCA ) -Université de Toulon ( UTLN ), Laboratory of Human Motricity, Education Sport and Health, University of Nice Sophia Antipolis, Nice, France The Ohio State University, UNITED STATES, Epilepsie et ischémie cérébrale, Université de la Méditerranée - Aix-Marseille 2-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Institut des Sciences du Mouvement Etienne Jules Marey ( ISM ), Centre National de la Recherche Scientifique ( CNRS ) -Aix Marseille Université ( AMU ), Laboratoire Motricité Humaine Expertise Sport Santé (LAMHESS), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université de Toulon (UTLN)-Université Côte d'Azur (UCA), Université de la Méditerranée - Aix-Marseille 2-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut des Sciences du Mouvement Etienne Jules Marey (ISM), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Université Nice Sophia Antipolis (1965 - 2019) (UNS), and Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)
Subjects: 0301 basic medicine, Male, medicine.medical_specialty, Quantitative Biology - Subcellular Processes, Lactate threshold, KCC2, Ischemia, microglia, [SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], Interval training, Brain Ischemia, 03 medical and health sciences, Grip strength, Random Allocation, 0302 clinical medicine, Grip force, Internal medicine, Physical Conditioning, Animal, Neuroplasticity, medicine, Aerobic exercise, Animals, Subcellular Processes (q-bio.SC), Advanced and Specialized Nursing, Neuronal Plasticity, [SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health, business.industry, [ SDV.BC.BC ] Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], Recovery of Function, medicine.disease, Surgery, Rats, p75 NTR, 030104 developmental biology, medicine.anatomical_structure, Treatment Outcome, FOS: Biological sciences, Quantitative Biology - Neurons and Cognition, Cardiology, Neurons and Cognition (q-bio.NC), Neurology (clinical), Forelimb, [ SDV.BA.MVSA ] Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health, Cardiology and Cardiovascular Medicine, Cotransporter, business, 030217 neurology & neurosurgery
Abstract: Background and Purpose— This study was designed to compare the effects of high-intensity interval training (HIT) and moderate-intensity aerobic training (MOD) on functional recovery and cerebral plasticity during the first 2 weeks after cerebral ischemia. Methods— Rats were randomized as follows: control (n=15), SHAM (n=9), middle cerebral artery occlusion (n=13), middle cerebral artery occlusion at day 1 (n=7), MOD (n=13), and HIT (n=13). Incremental tests were performed at day 1 (D1) and 14 (D14) to identify the running speed associated with the lactate threshold ( S LT ) and the maximal speed ( S max ). Functional tests were performed at D1, D7, and D14. Microglia form, cytokines, p75 NTR (pan-neurotrophin receptor p75), potassium–chloride cotransporter type 2, and sodium–potassium–chloride cotransporter type 1 expression were made at D15. Results— HIT was more effective to improve the endurance performance than MOD and induced a fast recovery of the impaired forelimb grip force. The ionized calcium binding adaptor molecule 1 (Iba-1)–positive cells with amoeboid form and the pro- and anti-inflammatory cytokine expression were lower in HIT group, mainly in the ipsilesional hemisphere. A p75 NTR overexpression is observed on the ipsilesional side together with a restored sodium–potassium–chloride cotransporter type 1/potassium–chloride cotransporter type 2 ratio on the contralesional side. Conclusions— Low-volume HIT based on lactate threshold seems to be more effective after cerebral ischemia than work-matched MOD to improve aerobic fitness and grip strength and might promote cerebral plasticity.
Published: 2017
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30. Patient demographics and surgical characteristics in ACL revision: a comparison of French, Norwegian, and North American cohorts

Author: Christophe Trojani, Philippe Neyret, Lars Engebretsen, Lars-Petter Granan, Christopher C. Kaeding, Philippe Colombet, Robert A. Magnussen, Rick W. Wright, Department of Orthopaedics, Sports Health and Performance Institute, Ohio State University [Columbus] (OSU), Service de Chirurgie Orthopédique et Chirurgie du Sport, Hôpital de L'Archet, University of Nice-Sophia Antipolis, Department of Physical Medicine and Rehabilitation, Oslo University Hospital [Oslo], Laboratoire de Biomécanique et Mécanique des Chocs (LBMC UMR T9406), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR), Centre de chirurgie orthopédique et sportive, Department of Orthopaedics, Department of Orthopaedic Surgery, and Washington University
Subjects: Adult, Male, Reoperation, medicine.medical_specialty, Patient demographics, MEDLINE, INTERNATIONAL, Norwegian, Bone-Patellar Tendon-Bone Grafting, Cohort Studies, Tendons, Young Adult, Humans, Medicine, RECONSTRUCTION, COHORT, Orthopedics and Sports Medicine, GENOU, Autografts, Retrospective Studies, Patient factors, Anterior Cruciate Ligament Reconstruction, Norway, business.industry, Anterior Cruciate Ligament Injuries, Graft Survival, MODELE AGE/COHORTE, Retrospective cohort study, Allografts, musculoskeletal system, language.human_language, REVISION, Family medicine, North America, CHIRURGIE, Orthopedic surgery, Cohort, ORTHOPEDIE, language, Physical therapy, Female, [SDV.IB]Life Sciences [q-bio]/Bioengineering, Surgery, France, business, ANTERIOR CRUCIATE LIGAMENT, Cohort study
Abstract: The goal of this paper is to compare patient factors, intra-operative findings, and surgical techniques between patients followed in large cohorts in France, Norway, and North America.Data collected on 2,286 patients undergoing revision anterior cruciate ligament reconstruction (ACLR) were obtained. These data included 1,216 patients enrolled in the Multicenter ACL Revision Study (MARS) in North America, 793 patients undergoing revision ACLR and recorded in the Norwegian Knee Ligament Registry (NKLR), and 277 patients recorded in the revision ACL database of the Société Française d'Arthroscopie (SFA) in France. Data collected from each database included patient demographics (age, sex, height, and weight), graft choice and reason for failure of the primary ACLR, time from primary to revision ACLR, pre-revision patient-reported outcome scores (Knee Injury and Osteoarthritis Outcome Score, subjective International Knee Documentation Committee), associated intra-articular findings and treatments at revision, and graft choice for revision reconstruction.Patient demographics in the three databases were relatively similar. Graft choice for primary and revision ACLR varied significantly, with more allografts used in the MARS cohort. Hamstring autograft was favoured in the NKRL, while bone-patellar tendon-bone autograft was most common in the SFA cohort. Reasons for failure of the primary ACLR were comparable, with recurrent trauma noted in 46-56 % of patients in each of the three cohorts. Technical error was cited in 44-51 % of patients in the MARS and SFA cohorts, but was not clearly elucidated in the NKLR cohort. Biologic failure of the primary graft was more common in the MARS cohort. Differences in associated intra-articular findings were noted at the time of revision ACLR, with significantly more high-grade cartilage lesions noted in the MARS group.Significant differences exist between patient populations followed in revision ACL cohorts throughout the world that should be considered when applying findings from such cohorts to different patient populations.Retrospective comparative study, Level III.
Published: 2014
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31. Post-translational modifications of Medicago truncatula glutathione peroxidase 1 induced by nitric oxide

Author: Françoise Montrichard, Renaud Brouquisse, Nicolas Rouhier, Aurélie Seassau, Claude Castella, Alain Puppo, Alexandre Boscari, Ioanna Mirtziou, Kalliopi K. Papadopoulou, Institut Sophia Agrobiotech (ISA), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Recherche Agronomique (INRA), University of Thessaly [Volos] (UTH), Institut de Recherche en Horticulture et Semences (IRHS), Université d'Angers (UA)-Institut National de la Recherche Agronomique (INRA)-AGROCAMPUS OUEST, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Interactions Arbres-Microorganismes (IAM), Institut National de la Recherche Agronomique (INRA)-Université de Lorraine (UL), Institut National de la Recherche Agronomique, Centre National de la Recherche Scientifique, University of Nice–Sophia Antipolis, National Research Agency ANR (ANR-11-LABX-0028-01, ANR-11-LABX-0002-01), University of Thessaly, State Scholarships Foundation, Institut Sophia Agrobiotech [Sophia Antipolis] (ISA), Institut National de la Recherche Agronomique (INRA)-Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Université de Lorraine (UL)-Institut National de la Recherche Agronomique (INRA), and AGROCAMPUS OUEST-Institut National de la Recherche Agronomique (INRA)-Université d'Angers (UA)
Subjects: 0301 basic medicine, Cancer Research, GPX1, GPX3, Physiology, Clinical Biochemistry, S-glutathionylation, Biochemistry, Gas Chromatography-Mass Spectrometry, 03 medical and health sciences, chemistry.chemical_compound, Glutathione Peroxidase GPX1, nitric oxide, régulation, [SDV.BV]Life Sciences [q-bio]/Vegetal Biology, Amino Acid Sequence, S-Glutathionylation, glutathione péroxydase, chemistry.chemical_classification, biology, Glutathione peroxidase, food and beverages, Glutathione, S-Nitrosylation, medicago truncatula, S-nitrosylation, 030104 developmental biology, chemistry, biology.protein, Protein Processing, Post-Translational, Peroxynitrite, glutathionylation, Peroxidase
Abstract: Plant glutathione peroxidases (Gpx) catalyse the reduction of various peroxides, such as hydrogen peroxide (H2O2), phospholipid hydroperoxides and peroxynitrite, but at the expense of thioredoxins rather than glutathione. A main function of plant Gpxs is the protection of biological membranes by scavenging phospholipid hydroperoxides, but some Gpxs have also been associated with H2O2 sensing and redox signal transduction. Nitric oxide (NO) is not only known to induce the expression of Gpx family members, but also to inhibit Gpx activity, presumably through the S-nitrosylation of conserved cysteine residues. In the present study, the effects of NO-donors on both the activity and S-nitrosylation state of purified Medicago truncatula Gpxl1 were analyzed using biochemical assay measurements and a biotin-switch/mass spectrometry approach. MtGpx1 activity was only moderately inhibited by the NO donors diethylamine-NONOate and S-nitrosoglutathione, and the inhibition may be reversed by DTT. The three conserved Cys of MtGpx1 were found to be modified through S-nitrosylation and S-glutathionylation, although to different extents, by diethylamine-NONOate and S-nitrosoglutathione, or by a combination of diethylamine-NONOate and reduced glutathione. The regulation of MtGpx1 and its possible involvement in the signaling process is discussed in the light of these results.
Published: 2017
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32. Point and line feature-based observer design on SL(3) for Homography estimation and its application to image stabilization

Author: Hua, Minh-Duc, Trumpf, Jochen, Hamel, Tarek, Mahony, Robert, Morin, Pascal, Laboratoire d'Informatique, Signaux, et Systèmes de Sophia-Antipolis (I3S) / Equipe OSCAR, Signal, Images et Systèmes (Laboratoire I3S - SIS), Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis (I3S), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis (I3S), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Australian National University - Department of engineering (ANU), Australian National University (ANU), Institut des Systèmes Intelligents et de Robotique (ISIR), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), I3S, Université Côte d'Azur, CNRS, University of Nice Sophia Antipolis, I3S, UMR 7271, COATI, Inria, 06900 Sophia Antipolis, France, Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), and HUA, Minh Duc
Subjects: [SPI.AUTO] Engineering Sciences [physics]/Automatic, ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION, [MATH.MATH-OC] Mathematics [math]/Optimization and Control [math.OC], [MATH.MATH-OC]Mathematics [math]/Optimization and Control [math.OC], [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, [SPI.SIGNAL] Engineering Sciences [physics]/Signal and Image processing, [SPI.AUTO]Engineering Sciences [physics]/Automatic
Abstract: This paper presents a new algorithm for online estimation of a sequence of homographies applicable to image sequences obtained from robotic vehicles equipped with a monocular camera. The approach taken exploits the underlying Special Linear group SL(3) structure of the set of homographies along with gyrometer measurements and direct point-and line-feature correspondences between images to develop temporal filter for the homography estimate. Theoretical analysis and experimental results are provided to demonstrate the robustness of the proposed algorithm. The experimental results show excellent performance even in the case of very fast camera motion (relative to frame rate), and in presence of severe occlusion, specular reflection, image blur, and light saturation.
Published: 2017

33. Regulation of Differentiation of Nitrogen-Fixing Bacteria by Microsymbiont Targeting of Plant Thioredoxin s1

Author: Marie M Larousse, Geneviève Alloing, Julie Hopkins, Pierre P Frendo, Sofiane Sm Benyamina, Jérémy Couturier, Pascal Gamas, Nicolas Rouhier, Claude Castella, Fabien Baldacci-Cresp, Olivier Pierre, Françoise Montrichard, Annie Lambert, Carolina Werner Cw Ribeiro, Julie Cazareth, Peter Mergaert, Eric Boncompagni, Institut Sophia Agrobiotech (ISA), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Recherche Agronomique (INRA), Institut de pharmacologie moléculaire et cellulaire (IPMC), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA), Interactions Arbres-Microorganismes (IAM), Institut National de la Recherche Agronomique (INRA)-Université de Lorraine (UL), Intéractions Plantes-Bactéries (PBI), Département Microbiologie (Dpt Microbio), Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Interactions plantes-microorganismes et santé végétale, Institut National de la Recherche Agronomique (INRA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche en Horticulture et Semences (IRHS), AGROCAMPUS OUEST, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de la Recherche Agronomique (INRA)-Université d'Angers (UA), Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (Brazil), French Ministere de l'Enseignement Superieur et de la Recherche, Institut National de la Recherche Agronomique, Centre National de la Recherche Scientifique, University of Nice-Sophia Antipolis, French Government (Agence Nationale de la Recherche [ANR]) : ANR-11-LABX-0028-01 ANR, Investissements d'Avenir program, ANR-11-LABX-0002-01, ANR-11-LABX-0028,SIGNALIFE,Réseau d'Innovation sur les Voies de Signalisation en Sciences de la Vie(2011), Institut Sophia Agrobiotech [Sophia Antipolis] (ISA), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Université Nice Sophia Antipolis (... - 2019) (UNS), Université de Lorraine (UL)-Institut National de la Recherche Agronomique (INRA), Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie Intégrative de la Cellule (I2BC), Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Université d'Angers (UA)-Institut National de la Recherche Agronomique (INRA)-AGROCAMPUS OUEST, ANR: 11-LABX-0028,SIGNALIFE,Réseau d'Innovation sur les Voies de Signalisation en Sciences de la Vie(2011), Institut National de la Recherche Agronomique (INRA)-Université Nice Sophia Antipolis (1965 - 2019) (UNS), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Institut Sophia Agrobiotech [Sophia Antipolis] ( ISA ), Centre National de la Recherche Scientifique ( CNRS ) -Université Nice Sophia Antipolis ( UNS ), Université Côte d'Azur ( UCA ) -Université Côte d'Azur ( UCA ) -Institut National de la Recherche Agronomique ( INRA ), Institut de pharmacologie moléculaire et cellulaire ( IPMC ), Université Nice Sophia Antipolis ( UNS ), Université Côte d'Azur ( UCA ) -Université Côte d'Azur ( UCA ) -Centre National de la Recherche Scientifique ( CNRS ), Interactions Arbres-Microorganismes ( IAM ), Institut National de la Recherche Agronomique ( INRA ) -Université de Lorraine ( UL ), Intéractions Plantes-Bactéries ( PBI ), Département Microbiologie ( Dpt Microbio ), Institut de Biologie Intégrative de la Cellule ( I2BC ), Université Paris-Sud - Paris 11 ( UP11 ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay-Centre National de la Recherche Scientifique ( CNRS ) -Université Paris-Sud - Paris 11 ( UP11 ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay-Centre National de la Recherche Scientifique ( CNRS ) -Institut de Biologie Intégrative de la Cellule ( I2BC ), Université Paris-Sud - Paris 11 ( UP11 ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay-Centre National de la Recherche Scientifique ( CNRS ) -Université Paris-Sud - Paris 11 ( UP11 ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay-Centre National de la Recherche Scientifique ( CNRS ), Université Paris-Sud - Paris 11 ( UP11 ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay-Centre National de la Recherche Scientifique ( CNRS ), Université Côte d'Azur ( UCA ) -Université Côte d'Azur ( UCA ) -Centre National de la Recherche Scientifique ( CNRS ) -Institut National de la Recherche Agronomique ( INRA ), Institut de Recherche en Horticulture et Semences ( IRHS ), Université d'Angers ( UA ) -Institut National de la Recherche Agronomique ( INRA ) -AGROCAMPUS OUEST, and ANR : LABEX SIGNALIFE,ANR-11-LABX-0028-01
Subjects: 0106 biological sciences, 0301 basic medicine, Nitrogen-Fixing Bacteria, animal structures, [SDV]Life Sciences [q-bio], nodule cysteine-rich peptides, 01 natural sciences, bacteroids, General Biochemistry, Genetics and Molecular Biology, thioredoxins, Rhizobia, disulfide bond reduction, nitrogen-fixing symbiosis, 03 medical and health sciences, Gene Expression Regulation, Plant, Medicago truncatula, Gene silencing, Endoreduplication, Cysteine, Symbiosis, Gene, Sinorhizobium meliloti, [ SDV ] Life Sciences [q-bio], biology, food and beverages, differentiation, biology.organism_classification, Peptide Fragments, 030104 developmental biology, Biochemistry, redox state, thiol modifications, Ectopic expression, Thioredoxin, General Agricultural and Biological Sciences, Root Nodules, Plant, 010606 plant biology & botany, Signal Transduction
Abstract: International audience; Legumes associate with rhizobia to form nitrogen (N2)-fixing nodules, which is important for plant fitness [1, 2]. Medicago truncatula controls the terminal differentiation of Sinorhizobium meliloti into N2-fixing bacteroids by producing defensin-like nodule-specific cysteine-rich peptides (NCRs) [3, 4]. The redox state of NCRs influences some biological activities in free-living bacteria, but the relevance of redox regulation of NCRs in planta is unknown [5, 6], although redox regulation plays a crucial role in symbiotic nitrogen fixation [7, 8]. Two thioredoxins (Trx), Trx s1 and s2, define a new type of Trx and are expressed principally in nodules [9]. Here, we show that there are four Trx s genes, two of which, Trx s1 and s3, are induced in the nodule infection zone where bacterial differentiation occurs. Trx s1 is targeted to the symbiosomes, the N2-fixing organelles. Trx s1 interacted with NCR247 and NCR335 and increased the cytotoxic effect of NCR335 in S. meliloti. We show that Trx s silencing impairs bacteroid growth and endoreduplication, two features of terminal bacteroid differentiation, and that the ectopic expression of Trx s1 in S. meliloti partially complements the silencing phenotype. Thus, our findings show that Trx s1 is targeted to the bacterial endosymbiont, where it controls NCR activity and bacteroid terminal differentiation. Similarly, Trxs are critical for the activation of defensins produced against infectious microbes in mammalian hosts. Therefore, our results suggest the Trx-mediated regulation of host peptides as a conserved mechanism among symbiotic and pathogenic interactions.
Published: 2016
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34. Poroelastic behavior of vitreous silica under rare gas compression

Author: Foret, Marie, Weigel, Coralie, Ruffle, Benoit, Polian, Alain, Coasne, Benoit, Vacher, Rene, Laboratoire Charles Coulomb (L2C), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut de minéralogie et de physique des milieux condensés (IMPMC), Université Pierre et Marie Curie - Paris 6 (UPMC)-IPG PARIS-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Interdisciplinaire de Physique [Saint Martin d’Hères] (LIPhy), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), LPMC CNRS UMR 7336, University of Nice Sophia Antipolis, and Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7)-Institut de Physique du Globe de Paris (IPG Paris)-Centre National de la Recherche Scientifique (CNRS)
Subjects: [PHYS.COND.CM-GEN]Physics [physics]/Condensed Matter [cond-mat]/Other [cond-mat.other]
Published: 2016

35. The cleaved FAS ligand activates the Na+/H+ exchanger NHE1 through Akt/ROCK1 to stimulate cell motility

Author: Patrick Legembre, Sébastien Tauzin, Dominique Lagadic-Gossmann, Michael Monet, Laurent Counillon, Mallorie Poët, Auréa Cophignon, Pierre Vacher, Amélie Fouqué, Laboratoire de PhysioMédecine Moléculaire (LP2M), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Institut de recherche en santé, environnement et travail (Irset), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de la Santé et de la Recherche Médicale (INSERM)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université d'Angers (UA), Oncogenesis Stress Signaling (OSS), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-CRLCC Eugène Marquis (CRLCC), Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] (CRCTB), Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux]-Institut National de la Santé et de la Recherche Médicale (INSERM), This work was supported by CNRS and the University of Nice-Sophia Antipolis, the ICST Labex, grants from INCa PLBIOL, Ligue Contre le Cancer (Comités d’Ille-et-Vilaine/du Morbihan/des Côtes d’Armor/du Maine et Loire), ARC, Région Bretagne, Rennes Métropole., Université Nice Sophia Antipolis (1965 - 2019) (UNS), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université de Rennes (UR)-CRLCC Eugène Marquis (CRLCC), and Jonchère, Laurent
Subjects: 0301 basic medicine, Fas Ligand Protein, RHOA, [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Article, Fas ligand, Cell Line, Metastasis, 03 medical and health sciences, 0302 clinical medicine, [SDV.CAN] Life Sciences [q-bio]/Cancer, Cell Movement, Humans, ROCK1, Cell migration, Phosphorylation, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, Protein kinase B, PI3K/AKT/mTOR pathway, ComputingMilieux_MISCELLANEOUS, rho-Associated Kinases, Sodium-Hydrogen Exchanger 1, Multidisciplinary, biology, Fas receptor, Cell biology, 030104 developmental biology, 030220 oncology & carcinogenesis, biology.protein, Cancer research, Protons, Signal transduction, rhoA GTP-Binding Protein, Proto-Oncogene Proteins c-akt, Signal Transduction
Abstract: Transmembrane CD95L (Fas ligand) can be cleaved to release a promigratory soluble ligand, cl-CD95L, which can contribute to chronic inflammation and cancer cell dissemination. The motility signaling pathway elicited by cl-CD95L remains poorly defined. Here, we show that in the presence of cl-CD95L, CD95 activates the Akt and RhoA signaling pathways, which together orchestrate an allosteric activation of the Na+/H+ exchanger NHE1. Pharmacologic inhibition of Akt or ROCK1 independently blocks the cl-CD95L-induced migration. Confirming these pharmacologic data, disruption of the Akt and ROCK1 phosphorylation sites on NHE1 decreases cell migration in cells exposed to cl-CD95L. Together, these findings demonstrate that NHE1 is a novel molecular actor in the CD95 signaling pathway that drives the cl-CD95L-induced cell migration through both the Akt and RhoA signaling pathways.
Published: 2016
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36. Analysis of the Failure Tolerance of Linear Access Networks

Author: Frédéric Giroire, Juan-Carlos Maureira, Combinatorics, Optimization and Algorithms for Telecommunications (COATI), COMmunications, Réseaux, systèmes Embarqués et Distribués (Laboratoire I3S - COMRED), Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis (I3S), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis (I3S), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Universidad de Chile = University of Chile [Santiago] (UCHILE), Associated Inria team AlDyNet, Project ECOS-Sud Chile, Center for Mathematical Modeling of the University of Chile. NLHPC Powered., CNRS, University of Nice Sophia Antipolis, I3S, UMR 7271, COATI, Inria, 06900 Sophia Antipolis, France, Center of Mathematical Modeling, University of Chile, Chile, Inria Sophia Antipolis, ANR-11-LABX-0031,UCN@SOPHIA,Réseau orienté utilisateur(2011), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-COMmunications, Réseaux, systèmes Embarqués et Distribués (Laboratoire I3S - COMRED), Center for Mathematical Modeling (CMM), Université Nice Sophia Antipolis (1965 - 2019) (UNS), and COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (1965 - 2019) (UNS)
Subjects: Engineering, Computer science, Access networks, Context (language use), Topology (electrical circuits), Interval (mathematics), 02 engineering and technology, Computer security, computer.software_genre, Network topology, Maintenance engineering, [INFO.INFO-NI]Computer Science [cs]/Networking and Internet Architecture [cs.NI], 0203 mechanical engineering, Telecommuting, 0202 electrical engineering, electronic engineering, information engineering, Sensitivity (control systems), Access network, failure tolerance, business.industry, Mechanical Engineering, maintenance cost, 020302 automobile design & engineering, 020206 networking & telecommunications, Computer Science Applications, telecommuting, Automotive Engineering, Disconnection, connectivity analysis, business, computer, Computer network
Abstract: In this paper, we study the disconnection of a moving vehicle from a linear access network composed by cheap WiFi Access Points in the context of the telecommuting in massive transportation systems. In concrete, we analyze the probability for a user to experience a disconnection longer than a threshold t∗, leading to a disruption of all on-going communications between the vehicle and the infrastructure network. We provide an approximation formula to estimate this probability for large networks. We then carry out a sensitivity analysis and supply a guide for operators when choosing the parameters of the networks. We focus on two scenarios: an intercity bus and an intercity train. Last, we show that such systems are viable, as they attain a very low probability of long disconnections with a very low maintenance cost.
Published: 2016
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37. Spatial Global Sensitivity Analysis of High Resolution classified topographic data use in 2D urban flood modelling

Author: Morgan Abily, Olivier Delestre, Nathalie Bertrand, Claire-Marie Duluc, Philippe Gourbesville, Innovative CiTy Lab (I-CiTy), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA), Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Mathématiques - Analyse, Probabilités, Modélisation - Orléans (MAPMO), Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS), Institut Jean le Rond d'Alembert (DALEMBERT), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Jean Alexandre Dieudonné (LJAD), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), IRSN, IRSN (Institut de Radioprotection et de Sûreté Nucléaire)/Innovative-CiTy URE 005, Polytech Nice (University of Nice Sophia Antipolis), Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Centre National de la Recherche Scientifique (CNRS)-Université d'Orléans (UO), Laboratoire Jean Alexandre Dieudonné (JAD), and COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)
Subjects: FOS: Computer and information sciences, Sensitivity maps, Environmental Engineering, 010504 meteorology & atmospheric sciences, Discretization, Computer science, 0208 environmental biotechnology, Probability density function, 02 engineering and technology, computer.software_genre, Statistics - Applications, 01 natural sciences, Urban flood, Shallow water equations, FOS: Mathematics, Applications (stat.AP), Mathematics - Numerical Analysis, Sensitivity (control systems), [SDU.STU.HY]Sciences of the Universe [physics]/Earth Sciences/Hydrology, FullSWOF_2D, 0105 earth and related environmental sciences, classified topographic data, [STAT.AP]Statistics [stat]/Applications [stat.AP], Observational error, Flood myth, [SDE.IE]Environmental Sciences/Environmental Engineering, Ecological Modeling, Numerical Analysis (math.NA), uncertainties, 020801 environmental engineering, Photogrammetry, Ranking, Spatial variability, Data mining, computer, Software, [MATH.MATH-NA]Mathematics [math]/Numerical Analysis [math.NA]
Abstract: This paper presents a spatial Global Sensitivity Analysis (GSA) approach in a 2D shallow water equations based High Resolution (HR) flood model. The aim of a spatial GSA is to produce sensitivity maps which are based on Sobol index estimations. Such an approach allows to rank the effects of uncertain HR topographic data input parameters on flood model output. The influence of the three following parameters has been studied: the measurement error, the level of details of above-ground elements representation and the spatial discretization resolution. To introduce uncertainty, a Probability Density Function and discrete spatial approach have been applied to generate 2, 000 DEMs. Based on a 2D urban flood river event modelling, the produced sensitivity maps highlight the major influence of modeller choices compared to HR measurement errors when HR topographic data are used, and the spatial variability of the ranking. Highlights $\bullet$ Spatial GSA allowed the production of Sobol index maps, enhancing the relative weight of each uncertain parameter on the variability of calculated output parameter of interest. 1 $\bullet$ The Sobol index maps illustrate the major influence of the modeller choices, when using the HR topographic data in 2D hydraulic models with respect to the influence of HR dataset accuracy. $\bullet$ Added value is for modeller to better understand limits of his model. $\bullet$ Requirements and limits for this approach are related to subjectivity of choices and to computational cost.
Published: 2016
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38. Surrogate data methods based on a shuffling of the trials for synchrony detection: the centering issue

Author: Yann Bouret, Mélisande Albert, Patricia Reynaud-Bouret, Magalie Fromont, Laboratoire Jean Alexandre Dieudonné (JAD), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de physique de la matière condensée (LPMC), Institut de Recherche Mathématique de Rennes (IRMAR), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École normale supérieure - Rennes (ENS Rennes)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-INSTITUT AGRO Agrocampus Ouest, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), University of Nice Sophia-Antipolis, University Rennes 2, PEPS BMI 2012- 2013, ANR-11-BS01-0010,Calibration,Calibration statistique(2011), Laboratoire Jean Alexandre Dieudonné ( JAD ), Université Nice Sophia Antipolis ( UNS ), Université Côte d'Azur ( UCA ) -Université Côte d'Azur ( UCA ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de physique de la matière condensée ( LPMC ), Centre National de la Recherche Scientifique ( CNRS ) -Université Nice Sophia Antipolis ( UNS ), Université Côte d'Azur ( UCA ) -Université Côte d'Azur ( UCA ), Institut de Recherche Mathématique de Rennes ( IRMAR ), Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -AGROCAMPUS OUEST-École normale supérieure - Rennes ( ENS Rennes ) -Institut National de Recherche en Informatique et en Automatique ( Inria ) -Institut National des Sciences Appliquées ( INSA ) -Université de Rennes 2 ( UR2 ), Université de Rennes ( UNIV-RENNES ) -Centre National de la Recherche Scientifique ( CNRS ), ANR-11-BS01-0010,Calibration,Calibration statistique ( 2011 ), Université Nice Sophia Antipolis (... - 2019) (UNS), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), AGROCAMPUS OUEST, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-École normale supérieure - Rennes (ENS Rennes)-Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), and Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)
Subjects: False discovery rate, Cognitive Neuroscience, Synchronization, 01 natural sciences, permutation, Coincidence, Surrogate data, 010104 statistics & probability, 03 medical and health sciences, Permutation, Independence Tests, 0302 clinical medicine, Arts and Humanities (miscellaneous), [MATH.MATH-ST]Mathematics [math]/Statistics [math.ST], 62P10, 62G10, [ MATH.MATH-ST ] Mathematics [math]/Statistics [math.ST], 0101 mathematics, bootstrap, Independence (probability theory), Mathematics, point process, Multiple Testing, [STAT.AP]Statistics [stat]/Applications [stat.AP], Shuffling, [ STAT.AP ] Statistics [stat]/Applications [stat.AP], Random permutation, Unitary Events, Trial-Shuffling, [ SDV.NEU ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Multiple comparisons problem, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Algorithm, 030217 neurology & neurosurgery
Abstract: International audience; We investigate several distribution-free dependence detection procedures, all based on a shuffling of the trials, from a statistical point of view. The mathematical justification of such procedures lies in the bootstrap principle and its approximation properties. In particular, we show that such a shuffling has mainly to be done on centered quantities-that is, quantities with zero mean under independence-to construct correct p-values, meaning that the corresponding tests control their false positive (FP) rate. Thanks to this study, we introduce a method, named permutation UE, which consists of a multiple testing procedure based on permutation of experimental trials and delayed coincidence count. Each involved single test of this procedure achieves the prescribed level, so that the corresponding multiple testing procedure controls the false discovery rate (FDR), and this with as few assumptions as possible on the underneath distribution, except independence and identical distribution across trials. The mathematical meaning of this assumption is discussed, and it is in particular argued that it does not mean what is commonly referred in neuroscience to as cross-trials stationarity. Some simulations show, moreover, that permutation UE outperforms the trial-shuffling of Pipa and Grün ( 2003 ) and the MTGAUE method of Tuleau-Malot et al. ( 2014 ) in terms of single levels and FDR, for a comparable amount of false negatives. Application to real data is also provided.
Published: 2016
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39. Global Sensitivity Analysis with 2D Hydraulic Codes: Application on Uncertainties Related to High-Resolution Topographic Data

Author: Olivier Delestre, Nathalie Bertrand, Morgan Abily, Claire-Marie Duluc, Philippe Gourbesville, Yann Richet, Innovative CiTy Lab (I-CiTy), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA), Laboratoire Jean Alexandre Dieudonné (JAD), Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS), Institut de Radioprotection et de Sûreté Nucléaire (IRSN), IRSN, Gourbesville, Philippe and Cunge, Jean. and Caignaert, Guy, IRSN - Institut de Radioprotection et de Sûreté Nucléaire, and I-CiTy & Polytech Nice Sophia - University of Nice Sophia Antipolis
Subjects: FOS: Computer and information sciences, 010504 meteorology & atmospheric sciences, Discretization, 0207 environmental engineering, Probability density function, Hydrograph, 02 engineering and technology, photogrammetry, Sobol index, 01 natural sciences, Computational Engineering, Finance, and Science (cs.CE), Global Sensitivity analysis, [SDU.STU.HY]Sciences of the Universe [physics]/Earth Sciences/Hydrology, Computer Science - Computational Engineering, Finance, and Science, 020701 environmental engineering, 0105 earth and related environmental sciences, Mathematics, Parametric statistics, urban flooding, [STAT.AP]Statistics [stat]/Applications [stat.AP], Propagation of uncertainty, Observational error, [SDE.IE]Environmental Sciences/Environmental Engineering, Sobol sequence, 2D numerical modeling, [INFO.INFO-NA]Computer Science [cs]/Numerical Analysis [cs.NA], [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation, Photogrammetry, 13. Climate action, [INFO.INFO-DC]Computer Science [cs]/Distributed, Parallel, and Cluster Computing [cs.DC], Algorithm, [MATH.MATH-NA]Mathematics [math]/Numerical Analysis [math.NA]
Abstract: International audience; Technologies such as aerial photogrammetry allow production of 3D topographic data including complex environments such as urban areas. Therefore, it is possible to create High Resolution (HR) Digital Elevation Models (DEM) incorporating thin above ground elements influencing overland flow paths. Even though this category of big data has a high level of accuracy, there are still errors in measurements and hypothesis under DEM elaboration. Moreover, operators look for optimizing spatial discretization resolution in order to improve flood models computation time. Errors in measurement, errors in DEM generation, and operator choices for inclusion of this data within 2D hydraulic model, might influence results of flood models simulations. These errors and hypothesis may influence significantly flood modelling results variability. The purpose of this study is to investigate uncertainties related to (i) the own error of high resolution topographic data, and (ii) the modeller choices when including topographic data in hydraulic codes. The aim is to perform a Global Sensitivity Analysis (GSA) which goes through a Monte-Carlo uncertainty propagation, to quantify impact of uncertainties, followed by a Sobol' indices computation, to rank influence of identified parameters on result variability. A process using a coupling of an environment for parametric computation (Prométhée) and a code relying on 2D shallow water equations (FullSWOF 2D) has been developed (P-FS tool). The study has been performed over the lower part of the Var river valley using the estimated hydrograph of 1994 flood event. HR topographic data has been made available for the study area, which is 17.5 km 2 , by Nice municipality. Three uncertain parameters were studied: the measurement error (var. E), the level of details of above-ground element representation in DEM (buildings, sidewalks, etc.) (var. S), and the spatial discretization resolution (grid cell size for regular mesh) (var. R). Parameter var. E follows a probability density function, whereas parameters var. S and var. R. are discrete operator choices. Combining these parameters, a database of 2, 000 simulations has been produced using P-FS tool implemented on a high performance computing structure. In our study case, the output of interest is the maximal
Published: 2016
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40. Wine industry Supply Chain: International Comparative Study using Social Networks Analysis

Author: Raymundo Forradellas, Joice De Almeida Goes, Didier Bédé, Laurence Saglietto, François Fulconis, Groupe de Recherche en Droit, Economie et Gestion (GREDEG), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Institut d'Administration des Entreprises (IAE) - Nice, Centre de Recherche sur le Transport et la Logistique (CRET-LOG), Aix Marseille Université (AMU), Laboratoire Biens, Normes, Contrats (LBNC), Avignon Université (AU), Laboratoire de Gestion et de Cognition (LGC), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Logistics Studies and Applications Centre (CEAL), National University of Cuyo, GFI, Université Nice Sophia Antipolis (1965 - 2019) (UNS), Institut d'Administration des Entreprises - Nice (IAE Nice), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA), Laboratoire Gouvernance et Contrôle Organisationnel (LGCO), Université de Toulouse (UT)-Université de Toulouse (UT), Universidad Nacional de Cuyo [Mendoza] (UNCUYO), and This work was supported by the collaborative programme ECOS-Sud/MINCyT which provided the initial framework for the University of Nice Sophia-Antipolis – GREDEG CNRS, France and CEAL – Universidad Nacional de Cuyo – Mendoza, Argentina [grant number A13H02] collaboration.
Subjects: Engineering, Knowledge management, Supply chain, media_common.quotation_subject, 0211 other engineering and technologies, Argentina, Qualitative property, 02 engineering and technology, Management Science and Operations Research, Management of Technology and Innovation, 0502 economics and business, Operations management, Business and International Management, wine, Social network analysis, media_common, Wine, Measure (data warehouse), 021103 operations research, Social network, business.industry, 05 social sciences, Social Networks Analysis (SNA), logistic, Wine Industry, Conceptual model, [SHS.GESTION]Humanities and Social Sciences/Business administration, 050211 marketing, France, business, Wine industry
Abstract: International audience; The objective of this research is to understand the structure of the Wine industry Supply Chain (WSC) using a social network approach in order to identify an appropriate performance measure for the WSC. We adopt a generic approach based on supply chain modelling, and conduct social networks analysis (SNA) to obtain a representation of the WSC. To assess the structure of the WSC, we consider the triad, group and whole network levels. We also conduct a comparative study of the New World and Old World WSCs based on data from the Mendoza Region (Argentina) (MA) and South-Eastern France (SEF) wine regions. We propose a conceptual model of the WSC which is tested using qualitative data from MA and SEF.
Published: 2016
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41. Reactive oxygen species and nitric oxide control early steps of the legume - rhizobium symbiotic interaction

Author: Renaud Brouquisse, Isabelle Damiani, Alain Puppo, Alexandre Boscari, Nicolas Pauly, Institut Sophia Agrobiotech (ISA), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Recherche Agronomique (INRA), Institut National de la Recherche Agronomique', 'Centre National de la Recherche Scientifique', University of Nice-Sophia Antipolis, French Government (National Research Agency, ANR) through the LABEX SIGNALIFE program [ANR-11-LABX-0028-01], ANR [CAROLS ANR-11-BSV7-010-02], and Boscari, Alexandre
Subjects: legume, nitric oxide, nitrogen fixation, Rhizobium, symbiosis, 0106 biological sciences, 0301 basic medicine, Cell division, Mini Review, [SDV]Life Sciences [q-bio], NADPH Oxidase, Plant Science, lcsh:Plant culture, Root hair, 01 natural sciences, Nitric oxide, 03 medical and health sciences, chemistry.chemical_compound, Symbiosis, Nitrate Reductases, lcsh:SB1-1110, Tip growth, chemistry.chemical_classification, Reactive oxygen species, NADPH oxidase, biology, biology.organism_classification, 030104 developmental biology, chemistry, Biochemistry, [SDE]Environmental Sciences, biology.protein, Reactive Oxygen Species, 010606 plant biology & botany
Abstract: International audience; The symbiotic interaction between legumes and nitrogen fixing rhizobium bacteria leads to the formation of a new organ, the nodule. Early steps of the interaction are characterized by the production of bacterial Nod factors, the reorientation of root-hair tip growth, the formation of an infection thread (IT) in the root hair, and the induction of cell division in inner cortical cells of the root, leading to a nodule primordium formation. Reactive oxygen species (ROS) and nitric oxide (NO) have been detected in early steps of the interaction. ROS/NO are determinant signals to arbitrate the specificity of this mutualistic association and modifications in their content impair the development of the symbiotic association. The decrease of ROS level prevents root hair curling and ITs formation, and that of NO conducts to delayed nodule formation. In root hairs, NADPH oxidases were shown to produce ROS which could be involved in the hair tip growth process. The use of enzyme inhibitors suggests that nitrate reductase and NO synthase-like enzymes are the main route for NO production during the early steps of the interaction. Transcriptomic analyses point to the involvement of ROS and NO in the success of the infection process, the induction of early nodulin gene expression, and the repression of plant defense, thereby favoring the establishment of the symbiosis. The occurrence of an interplay between ROS and NO was further supported by the finding of both S-sulfenylated and S-nitrosylated proteins during early symbiotic interaction, linking ROS/NO production to a redox-based regulation of the symbiotic process.
Published: 2016
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42. Lebein, a snake venom disintegrin, suppresses human colon cancer cells proliferation and tumor-induced angiogenesis through cell cycle arrest, apoptosis induction and inhibition of VEGF expression

Author: Ons, Zakraoui, Cezary, Marcinkiewicz, Zohra, Aloui, Houcemeddine, Othman, Renaud, Grépin, Meriam, Haoues, Makram, Essafi, Najet, Srairi-Abid, Ammar, Gasmi, Habib, Karoui, Gilles, Pagès, Khadija, Essafi-Benkhadir, Laboratoire d'Epidémiologie Moléculaire et de Pathologie Expérimentale Appliquée aux Maladies Infectieuses (LR11IPT04), Université de Tunis El Manar (UTM)-Institut Pasteur de Tunis, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Université de Tunis El Manar (UTM), Temple University [Philadelphia], Pennsylvania Commonwealth System of Higher Education (PCSHE), Laboratoire des Venins et Biomolécules Thérapeutiques - Laboratory of Venoms and Therapeutic Biomolecules (LR11IPT08), Institut Pasteur de Tunis, Centre Scientifique de Monaco (CSM), Laboratoire de Transmission, Contrôle et Immunobiologie des Infections - Laboratory of Transmission, Control and Immunobiology of Infection (LR11IPT02), Institut de Recherche sur le Cancer et le Vieillissement (IRCAN), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), and This work was supported by the Tunisian Ministry of Higher Education and Scientific Research, the Institut Pasteur International Network (RIIP) and the University of Nice Sophia Antipolis, the French National Institute of Cancer (INCA) and the French Association for cancer research (ARC).
Subjects: Models, Molecular, Vascular Endothelial Growth Factor A, MESH: Vascular Endothelial Growth Factor A/genetics, MESH: Neovascularization, Pathologic/drug therapy, MESH: Colonic Neoplasms/drug therapy, MESH: Colonic Neoplasms/pathology, Apoptosis, MESH: MAP Kinase Signaling System/drug effects, MESH: Cell Proliferation/drug effects, Lebein, MESH: Colon/drug effects, MESH: Animals, MESH: Colon/metabolism, Neovascularization, Pathologic, MESH: Antineoplastic Agents/pharmacology, Integrin beta1, MESH: Chickens, MESH: Neovascularization, Pathologic/genetics, disintegrin, tumor growth, colon cancer, Colonic Neoplasms, MESH: Antineoplastic Agents/therapeutic use, MESH: Models, Molecular, MESH: Apoptosis/drug effects, MESH: Cell Line, Tumor, Colon, MAP Kinase Signaling System, MESH: Vascular Endothelial Growth Factor A/metabolism, Down-Regulation, Mice, Nude, Antineoplastic Agents, MESH: Viper Venoms/therapeutic use, [SDV.CAN]Life Sciences [q-bio]/Cancer, Viper Venoms, MESH: Cell Cycle Checkpoints/drug effects, MESH: Viper Venoms/pharmacology, Cell Line, Tumor, MESH: Down-Regulation/drug effects, MESH: Mice, Nude, Animals, Humans, MESH: Integrin beta1/metabolism, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Cell Proliferation, cellular effectors, MESH: Humans, Cell Cycle Checkpoints, MESH: Colonic Neoplasms/metabolism, MESH: Reactive Oxygen Species/metabolism, MESH: Colonic Neoplasms/genetics, MESH: Neovascularization, Pathologic/metabolism, MESH: Neovascularization, Pathologic/pathology, MESH: Colon/pathology, Reactive Oxygen Species, Chickens, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: Lebein, is an heterodimeric disintegrin isolated from Macrovipera lebetina snake venom that was previously characterized as an inhibitor of ADP-induced platelet aggregation. In this study, we investigated the effect of Lebein on the p53-dependent growth of human colon adenocarcinoma cell lines. We found that Lebein significantly inhibited LS174 (p53wt), HCT116 (p53wt), and HT29 (p53mut) colon cancer cell viability by inducing cell cycle arrest through the modulation of expression levels of the tumor suppression factor p53, cell cycle regulating proteins cyclin D1, CDK2, CDK4, retinoblastoma (Rb), CDK1, and cyclin-dependent kinase inhibitors p21 and p27. Interestingly, Lebein-induced apoptosis of colon cancer cells was dependent on their p53 status. Thus, in LS174 cells, cell death was associated with PARP cleavage and the activation of caspases 3 and 8 while in HCT116 cells, Lebein induced caspase-independent apoptosis through increased expression of apoptosis inducing factor (AIF). In LS174 cells, Lebein triggers the activation of the MAPK ERK1/2 pathway through induction of reactive oxygen species (ROS). It also decreased cell adhesion and migration to fibronectin through down regulation of α5β1 integrin. Moreover, Lebein significantly reduced the expression of two angiogenesis stimulators, Vascular Endothelial Growth Factor (VEGF) and Neuropilin 1 (NRP1). It inhibited the VEGF-induced neovascularization process in the quail embryonic CAM system and blocked the development of human colon adenocarcinoma in nude mice. Overall, our work indicates that Lebein may be useful to design a new therapy against colon cancer. © 2016 Wiley Periodicals, Inc.
Published: 2016
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43. Use of 3D classified topographic data with FullSWOF for high resolution simulation of a river flood event over a dense urban area

Author: Abily, Morgan, Delestre, Olivier, Amossé, Laura, Bertrand, Nathalie, Laguerre, Christian, Duluc, Claire-Marie, Gourbesville, Philippe, Innovative CiTy Lab (I-CiTy), Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Polytech'Nice Sophia, Université Nice Sophia Antipolis (... - 2019) (UNS), Laboratoire Jean Alexandre Dieudonné (JAD), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS), Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Mathématiques - Analyse, Probabilités, Modélisation - Orléans (MAPMO), Centre National de la Recherche Scientifique (CNRS)-Université d'Orléans (UO), IRSN, IAHR, IRSN - Institut de Radioprotection et de Sûreté Nucléaire, and Polytech Nice Sophia & I-CiTy, University of Nice Sophia Antipolis
Subjects: FOS: Computer and information sciences, surface model, Saint-Venant, hydrostatic reconstruction, photogrammetry, Computational Engineering, Finance, and Science (cs.CE), Shallow-Water equation, DSM, Mathematics - Analysis of PDEs, FullSWOF, parallelization, Var river, FOS: Mathematics, [MATH.MATH-AP]Mathematics [math]/Analysis of PDEs [math.AP], Mathematics - Numerical Analysis, [SDU.STU.HY]Sciences of the Universe [physics]/Earth Sciences/Hydrology, Computer Science - Computational Engineering, Finance, and Science, high resolution modelling, flood hazard, [SDE.IE]Environmental Sciences/Environmental Engineering, Numerical Analysis (math.NA), [INFO.INFO-NA]Computer Science [cs]/Numerical Analysis [cs.NA], [INFO.INFO-DC]Computer Science [cs]/Distributed, Parallel, and Cluster Computing [cs.DC], finite volume, well-balanced, [MATH.MATH-NA]Mathematics [math]/Numerical Analysis [math.NA], Analysis of PDEs (math.AP)
Abstract: High resolution (infra-metric) topographic data, including photogram-metric born 3D classified data, are becoming commonly available at large range of spatial extend, such as municipality or industrial site scale. This category of dataset is promising for high resolution (HR) Digital Surface Model (DSM) generation, allowing inclusion of fine above-ground structures which might influence overland flow hydrodynamic in urban environment. Nonetheless several categories of technical and numerical challenges arise from this type of data use with standard 2D Shallow Water Equations (SWE) based numerical codes. FullSWOF (Full Shallow Water equations for Overland Flow) is a code based on 2D SWE under conservative form. This code relies on a well-balanced finite volume method over a regular grid using numerical method based on hydrostatic reconstruction scheme. When compared to existing industrial codes used for urban flooding simulations, numerical approach implemented in FullSWOF allows to handle properly flow regime changes, preservation of water depth positivity at wet/dry cells transitions and steady state preservation. FullSWOF has already been tested on analytical solution library (SWASHES) and has been used to simulate runoff and dam-breaks. FullSWOFs above mentioned properties are of good interest for urban overland flow. Objectives of this study are (i) to assess the feasibility and added values of using HR 3D classified topographic data to model river overland flow and (ii) to take advantage of FullSWOF code properties for overland flow simulation in urban environment., Comment: 3rd IAHR Europe Congress, 14-16 April 2014, Porto, Portugal, Apr 2014, Porto, Portugal. 2016
Published: 2016
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44. Increased CD271 expression by the NF-kB pathway promotes melanoma cell survival and drives acquired resistance to BRAF inhibitor vemurafenib

Author: Lehraiki, Abdelali, Cerezo, Michaël, Rouaud, Florian, Abbe, Patricia, Allegra, Marilyne, Kluza, Jerome, Marchetti, Philippe, Imbert, Véronique, Cheli, Yann, Bertolotto, Corine, Ballotti, Robert, Rocchi, Stéphane, Centre méditerranéen de médecine moléculaire (C3M), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U1172 Inserm - U837 (JPArc), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Lille Nord de France (COMUE)-Université de Lille, This research was supported by the INSERM, University of Nice Sophia Antipolis, ARC contract n° PJA 20141201849, SILAB fondation and the ‘INCA Recherche Translationnelle 2011’. AL is a recipient of a doctoral fellowship from the ‘Fondation de France’. INSERM U1065, team 1 is ‘équipe labelisée ligue 2013’., Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA), Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 (JPArc), Université Lille Nord de France (COMUE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, and BERTOLOTTO-BALLOTTI, BERTOLOTTO-BALLOTTI
Subjects: resistance, [SDV.CAN] Life Sciences [q-bio]/Cancer, TNFα, melanoma, vemurafenib, [SDV.CAN]Life Sciences [q-bio]/Cancer, Article, NF-κB, CD271
Abstract: International audience; Specific BRAFV600E inhibitors (BRAFi) are highly effective in the treatment of melanoma. However, acquired drug resistances invariably develop after the initial response. Therefore, the identification of new mechanisms of acquired resistance gives important clues towards the development of therapies that could elicit long lasting responses. Here we report that CD271 confers resistance to BRAFi in melanoma cells. The expression of CD271 is increased by BRAFi through a stimulation of tumor necrosis factor-alpha (TNFα) secretion that leads to NF-κB signaling pathway activation. CD271 is upregulated in a subset of BRAFi-resistant melanoma cells. The inhibition of TNFα/NF-κB pathway and CD271 silencing restore the BRAFi sensitivity of resistant melanoma cells. Finally, increase of CD271 expression is validated in BRAFi-resistant xenografts tumors and also in tumors from the patients who relapsed under BRAFi. In summary, these results reveal a novel TNFα/NF-κB/CD271 axis whose activation contributes to the acquisition of resistance to BRAFi and therefore may represent a novel therapeutic target to improve the efficacy of therapy in melanoma.
Published: 2015
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45. A data-dependent weighted LASSO under Poisson noise

Author: Laure Sansonnet, Rebecca Willett, Vincent Rivoirard, Patricia Reynaud-Bouret, Xin Jiang Hunt, Department of Electrical and Computer Engineering [Durham] (ECE), Duke University [Durham], Laboratoire Jean Alexandre Dieudonné (JAD), Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), CEntre de REcherches en MAthématiques de la DEcision (CEREMADE), Université Paris Dauphine-PSL-Centre National de la Recherche Scientifique (CNRS), Mathématiques et Informatique Appliquées (MIA-Paris), AgroParisTech-Institut National de la Recherche Agronomique (INRA), SAS Institute Inc. (SAS-I), Institute Inc., Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Paris Dauphine-PSL, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Department of Mathematics, Statistics and Computer Science [Chicago] (UIC), University of Illinois [Chicago] (UIC), University of Illinois System-University of Illinois System, AFOSR Award [14-AFOSR-1103], NSF [CCF-1418976], University of Nice Sophia Antipolis Visiting Professor Program, ANR [BS01 010 01], Chaire Economie et Gestion des Nouvelles Donnees under Institut Louis Bachelier, Havas-Media, Paris-Dauphine, ANR-15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015), and ANR-19-P3IA-0002,3IA@cote d'azur,3IA Côte d'Azur(2019)
Subjects: FOS: Computer and information sciences, genetic motifs, Computer science, Computer Science - Information Theory, Gaussian, Mathematics - Statistics Theory, 02 engineering and technology, Statistics Theory (math.ST), Library and Information Sciences, Poisson distribution, symbols.namesake, Lasso (statistics), photon-limited imaging, [MATH.MATH-ST]Mathematics [math]/Statistics [math.ST], 0202 electrical engineering, electronic engineering, information engineering, FOS: Mathematics, Poisson noise, Applied mathematics, Sparse matrix, compressed sensing, Information Theory (cs.IT), Shot noise, Estimator, 020206 networking & telecommunications, Inverse problem, Computer Science Applications, Compressed sensing, Terms Weighted LASSO, symbols, Information Systems
Abstract: Sparse linear inverse problems appear in a variety of settings, but often the noise contaminating observations cannot accurately be described as bounded by or arising from a Gaussian distribution. Poisson observations in particular are a feature of several real-world applications. Previous work on sparse Poisson inverse problems encountered several limiting technical hurdles. This paper describes a novel alternative analysis approach for sparse Poisson inverse problems that (a) sidesteps the technical challenges in previous work, (b) admits estimators that can readily be computed using off-the-shelf LASSO algorithms, and (c) hints at a general framework for broad classes of noise in sparse linear inverse problems. At the heart of this new approach lies a weighted LASSO estimator for which data-dependent weights are based on Poisson concentration inequalities. Unlike previous analyses of the weighted LASSO, the proposed analysis depends on conditions which can be checked or shown to hold in general settings with high probability., Comment: 25 pages (48 pages with appendix), 3 figures
Published: 2015
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46. Exploration of the scalability of LocFaults approach for error localization with While-loops programs

Author: Bekkouche, Mohammed, Laboratoire d'Informatique, Signaux, et Systèmes de Sophia-Antipolis (I3S) / Equipe CEP, Modèles Discrets pour les Systèmes Complexes (Laboratoire I3S - MDSC), Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis (I3S), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis (I3S), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), and University of Nice-Sophia Antipolis, I3S/CNRS BP 121, 06903 Sophia Antipolis Cedex, France
Subjects: Minimal Correction Deviations, Minimal Correction Subsets, LocFaults, [INFO.INFO-SE]Computer Science [cs]/Software Engineering [cs.SE], BugAssist, Error localization, Off-by-one bug, [INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI]
Abstract: A model checker can produce a trace of counterexample, for an erroneous program, which is often long and difficult to understand. In general, the part about the loops is the largest among the instructions in this trace. This makes the location of errors in loops critical, to analyze errors in the overall program. In this paper, we explore the scala-bility capabilities of LocFaults, our error localization approach exploiting paths of CFG(Control Flow Graph) from a counterexample to calculate the MCDs (Minimal Correction Deviations), and MCSs (Minimal Correction Subsets) from each found MCD. We present the times of our approach on programs with While-loops unfolded b times, and a number of deviated conditions ranging from 0 to n. Our preliminary results show that the times of our approach, constraint-based and flow-driven, are better compared to BugAssist which is based on SAT and transforms the entire program to a Boolean formula, and further the information provided by LocFaults is more expressive for the user.
Published: 2015

47. Nitric oxide: a multifaceted regulator of the nitrogen-fixing symbiosis

Author: Alexandre Boscari, Claude Castella, Renaud Brouquisse, Imène Hichri, Martina Rovere, Alain Puppo, Institut Sophia Agrobiotech (ISA), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Recherche Agronomique (INRA), Institut National de la Recherche Agronomique, Centre National de la Recherche Scientifique, University of Nice-Sophia Antipolis, and French Government (National Research Agency, ANR) through the LABEX SIGNALIFE programme (ANR-11-LABX-0028-01)
Subjects: Senescence, biology, Physiology, hypoxia, Nitrogenase, Nodule (medicine), Fabaceae, Plant Science, legume, biology.organism_classification, symbiosis, Cell biology, Symbiosis, nitric oxide, nitrogen fixation, Botany, Nitrogen fixation, medicine, Rhizobium, [SDV.BV]Life Sciences [q-bio]/Vegetal Biology, medicine.symptom, Nitrogen cycle, Bacteria
Abstract: International audience; The specific interaction between legumes and Rhizobium-type bacteria leads to the establishment of a symbiotic relationship characterized by the formation of new differentiated organs named nodules, which provide a niche for bacterial nitrogen (N2) fixation. In the nodules, bacteria differentiate into bacteroids with the ability to fix atmospheric N2 via nitrogenase activity. As nitrogenase is strongly inhibited by oxygen, N2 fixation is made possible by the microaerophilic conditions prevailing in the nodules. Increasing evidence has shown the presence of NO during symbiosis, from early interaction steps between the plant and the bacterial partners to N2-fixing and senescence steps in mature nodules. Both the plant and the bacterial partners participate in NO synthesis. NO was found to be required for the optimal establishment of the symbiotic interaction. Transcriptomic analysis at an early stage of the symbiosis showed that NO is potentially involved in the repression of plant defence reactions, favouring the establishment of the plant-microbe interaction. In mature nodules, NO was shown to inhibit N2 fixation, but it was also demonstrated to have a regulatory role in nitrogen metabolism, to play a beneficial metabolic function for the maintenance of the energy status under hypoxic conditions, and to trigger nodule senescence. The present review provides an overview of NO sources and multifaceted effects from the early steps of the interaction to the senescence of the nodule, and presents several approaches which appear to be particularly promising in deciphering the roles of NO in N2-fixing symbioses.
Published: 2015
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48. Quelques contributions à la modélisation géométrique d'environnements urbains

Author: Lafarge, Florent, Geometric Modeling of 3D Environments (TITANE), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), University of Nice Sophia Antipolis, and Pierre Alliez
Subjects: scènes urbaines, géométrie algorithmique, détection d'objets, surface reconstruction, geometry processing, vision par ordinateur, [INFO.INFO-CV]Computer Science [cs]/Computer Vision and Pattern Recognition [cs.CV], Computer vision, object detection, urban reconstruction, reconstruction de surface, [INFO.INFO-CG]Computer Science [cs]/Computational Geometry [cs.CG], 3D modeling
Abstract: This habilitation thesis proposes a series of contributions in the field of geometric modeling from physical measurements. These contributions present concepts and algorithms for object extraction, surface reconstruction, and scene modeling for urban environments. The methodology behind these contributions relies on stochastic geometry and graphical models. These probabilistic models are suited to analyzing the diversity and the complexity of urban objects and to exploring large and highly non-convex solution spaces at city-scales. The physical measurements, data structures, and concepts involved in our work lie between computer vision, geometry processing, and photogrammetry. A general summary also provides a vision of the many remaining challenges in the field.
Published: 2014

49. Discrete maximum principle and the Ultraviolet Catastrophe of finite difference schemes on staggered Cartesian grids for heterogeneous and anisotropic diffusion equations

Author: Dani, Roberta, Simeoni, Chiara, Department of Information Engineering, Computer Science and Mathematics = Dipartimento di Ingegneria e Scienze dell'Informazione e Matematica [L'Aquila] (DISIM), Università degli Studi dell'Aquila (UNIVAQ), Université Côte D'Azur, CNRS, LJAD (France), University of Nice-Sophia Antipolis, France, and Dipartimento di Ingegneria e Scienze dell'Informazione e Matematica [L'Aquila] (DISIM)
Subjects: consistency and stability, Ultraviolet Catastrophe, staggered Cartesian grids, discrete maximum principle, anisotropic diffusion, [MATH.MATH-AP]Mathematics [math]/Analysis of PDEs [math.AP], non-negativity constraints, finite difference/volume schemes, [INFO.INFO-NA]Computer Science [cs]/Numerical Analysis [cs.NA], [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation, [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], [MATH.MATH-NA]Mathematics [math]/Numerical Analysis [math.NA]
Abstract: The maximum principle, closely related to the non-negativity property, is a basic characteristic of second order PDEs of parabolic type. Its preservation for solutions to corresponding discretized problems is a natural requirement in reliable and meaningful numerical modeling of various real-life phenomena. Finite difference or finite volume methods on staggered Cartesian grids have the advantage of being easily parallelizable, for example in CUDA GPUs, with several processes performing at the same time to greatly decrease the computational costs. The aim of this report is to give a uniform introduction to finite difference/volume schemes for approaching anisotropic and heterogeneous diffusion equations, for which the validity of the discrete maximum/minimum principle is satisfied. Details are provided about the stability analysis for one-dimensional and two-dimensional problems, through the algebraic theory of positive matrices, to determine the range of numerical parameters under which fundamental properties are fulfilled. An extensive series of numerical tests is proposed to experimentally validate the theoretical results.
Published: 2014

50. Naturally dissolved arsenic concentrations in the Alpine/Mediterranean Var River watershed (France)

Author: Roland Simler, Aurélie Barats, Yves Travi, Michel Dubar, Gilbert Féraud, Gaël Durrieu, Cécile Potot, Violaine Philippini, Laboratoire de Chimie Analytique Bio-Inorganique et Environnement (LCABIE), Université de Pau et des Pays de l'Adour (UPPA)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Radiochimie et des Sciences Analytiques et Environnement (LRSAE/EA 1175), Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA), Physique des interactions ioniques et moléculaires (PIIM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Radiochimie et des Sciences Analytiques et Environnement (LRSAE), Institut de Chimie de Nice (ICN), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Environnement Méditerranéen et Modélisation des Agro-Hydrosystèmes (EMMAH), Avignon Université (AU)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), ONERA - The French Aerospace Lab [Toulouse], ONERA, Laboratoire de Thermique, Ecoulements Mécaniques matériaux mise en forme PrOduction (TEMPO), Université Polytechnique Hauts-de-France (UPHF), Laboratoire d'Hydrogéologie d'Avignon (LHA), Avignon Université (AU), Laboratoire de Chimie Analytique Bio-Inorganique et Environnement ( LCABIE ), Université de Pau et des Pays de l'Adour ( UPPA ) -Centre National de la Recherche Scientifique ( CNRS ), Université Nice Sophia Antipolis ( UNS ), Université Côte d'Azur ( UCA ) -Université Côte d'Azur ( UCA ), Physique des interactions ioniques et moléculaires ( PIIM ), Aix Marseille Université ( AMU ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Radiochimie et des Sciences Analytiques et Environnement ( LRSAE ), Institut de Chimie de Nice ( ICN ), Université Côte d'Azur ( UCA ) -Université Côte d'Azur ( UCA ) -Centre National de la Recherche Scientifique ( CNRS ), Environnement Méditerranéen et Modélisation des Agro-Hydrosystèmes ( EMMAH ), Institut National de la Recherche Agronomique ( INRA ) -Université d'Avignon et des Pays de Vaucluse ( UAPV ), ONERA - The French Aerospace Lab ( Toulouse ), Laboratoire de Thermique, Ecoulements Mécaniques matériaux mise en forme PrOduction ( TEMPO ), Université de Valenciennes et du Hainaut-Cambresis ( UVHC ), Laboratoire d'Hydrogéologie d'Avignon ( LHA ), Université d'Avignon et des Pays de Vaucluse ( UAPV ), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), Université de Valenciennes et du Hainaut-Cambrésis (UVHC), Conseil General des Alpes-Maritimes, Conseil Regional Provence Alpes Cote d'Azur, Syndicat Mixte d'Etudes de la Basse Vallee du Var, Agence de l'Eau, Plan Pluri-Formation of the University of Nice Sophia-Antipolis, Veolia-Eau, Université Nice Sophia Antipolis (1965 - 2019) (UNS), and COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)
Subjects: Rocks, Mediterranean climate, Geologic Sediments, Environmental Engineering, Permian, Metamorphic rock, Drainage basin, 010501 environmental sciences, 010502 geochemistry & geophysics, 01 natural sciences, Mediterranean Basin, Arsenic, [ SDE ] Environmental Sciences, Mediterranean sea, Rivers, Tributary, Environmental Chemistry, Waste Management and Disposal, 0105 earth and related environmental sciences, Arsenopyrite, Hydrology, geography, geography.geographical_feature_category, Pollution, 6. Clean water, Transfer, visual_art, [SDE]Environmental Sciences, visual_art.visual_art_medium, France, Water Pollutants, Chemical, Geology, Environmental Monitoring
Abstract: International audience; • Variations of dissolved arsenic concentration according to water/rock interactions • As in river water originates from Perm-ian and Hercynian metamorphic rocks • 4.2 tons⋅year − 1 of dissolved As is transferred to the Mediterranean Sea. • The use of a mixing model supports the non-conservative nature of arsenic. A detailed study on arsenic (As) in rocks and water from the Var River watershed was undertaken aiming at identifying (i) the origin and the distribution of As in this typical Alpine/Mediterranean basin, and (ii) As input into the Mediterranean Sea. Dissolved As concentrations in the Var River range from 0.1 to 4.5 μg⋅L −1 , due to high hydrological variability and the draining through different geological formations. In the upper part of the Var drainage basin, in the Tinée and the Vésubie valleys, high levels of dissolved As concentrations occur (up to 263 μg ⋅ L −1). The two main sources of As in rocks are the Hercynian metamorphic rocks and the Permian argilites. Highly heterogeneous distribution of As in waters draining through metamorphic rocks is probably related to ore deposits containing arsenopyrite. As, U, W and Mo concentrations in water and rocks correspond to the formation of As-rich ore deposits around Argentera granite by hydrothermal fluids deposited at the end of the Hercynian chain formation, which occurred about 300 My ago. In 2009, weekly monitoring was performed on the Var River (15 km upstream of the mouth), highlighting an average dissolved As concentration (b0.45 μm) of 2.7 ± 0.9 μg⋅L −1 , which is significantly higher than the world-average baseline for river water (0.83 μg ⋅ L −1). Taking the average annual discharge (49.4 m 3 ⋅ s −1) into account and the As levels in the dissolved phase and in deposits of the Var River, dissolved As input into the Mediterranean Sea would be 4.2 ± 1.4 tons⋅year −1 which represents 59% of the total As flux. This study also reveals a probable non-conservative As behaviour, i.e., possible transfer between aqueous and solid phases, during the mixing of the Var River with a tributary.
Published: 2014
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