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1. Editor's note

Author: KL Goh Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia
Subjects: Diseases of the digestive system. Gastroenterology, RC799-869
Published: 2020
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2. Finite element analysis of the flexural behavior of square CFST beams at ambient and elevated temperature

Author: University of Malaya, Kuala Lumpur, Javed, Muhammad, Ramli Sulong, Nor Hafizah, Khan, Niaz, Kashif, Sardar, University of Malaya, Kuala Lumpur, Javed, Muhammad, Ramli Sulong, Nor Hafizah, Khan, Niaz, and Kashif, Sardar
Abstract: [EN] This paper presents the finite element (FE) analysis and modeling of square concrete-filled steel tube (CFST) members subjected to a flexural load at ambient and elevated temperature. The commercial FE tool ANSYS was used in the 3D modeling taking into consideration material and geometric non-linearities. The developed FE model can accurately predict the ultimate moment capacity of the square CFST members subjected to flexural loads and fire resistance time. A parametric study is conducted using the verified FE model to study the effect of the compressive strength of infilled concrete and the yield strength of the steel tube on the flexural behavior of the square CFST members. The ultimate bending capacity of the CFST members increases by up to 27% when the yield strength of the steel tube increases from 210 MPa to 400 MPa while its fire resistance time decreases. For a D/t ratio equal to 30, the flexural capacity increases by 20% when the compressive strength of the infilled concrete increases from 60 MPa to 100 MPa, while it shows increase in fire resistance time.
Published: 2018

3. A Survey on Proxy Mobile IPv6 Handover

Author: Universitat Politècnica de València. Departamento de Comunicaciones - Departament de Comunicacions, University of Malaya, Kuala Lumpur, Modares, Hero, Moravejosharieh, Amirhossein, Lloret, Jaime, Salleh, R.B., Universitat Politècnica de València. Departamento de Comunicaciones - Departament de Comunicacions, University of Malaya, Kuala Lumpur, Modares, Hero, Moravejosharieh, Amirhossein, Lloret, Jaime, and Salleh, R.B.
Abstract: [EN] As wireless technologies have been improving in recent years, a mobility management mechanism is required to provide seamless and ubiquitous mobility for end users who are roaming among points of attachment in wireless networks. Thus, Mobile IPv6 was developed by the Internet Engineering Task Force (IETF) to support the mobility service. However, Mobile IPv6 is unable to fulfill the requirements of real-time applications, such as video streaming service and voice over IP service, due to its high handover (HO) latency. To address this problem, Proxy Mobile IPv6 (PMIPv6) has been introduced by the IETF. In PMIPv6, which is a network-based approach, the serving network controls mobility management on behalf of the mobile node (MN). Thus, the MN is not required to participate in any mobility-related signaling. However, the PMIPv6 still suffers from lengthy HO latency and packet loss during a HO. This paper explores an elaborated survey on the HO procedure of PMIPv6 protocols and proposed approaches accompanied by a discussion about their points of weakness.
Published: 2016

4. A survey of secure protocols in Mobile IPv6

Author: Universitat Politècnica de València. Departamento de Comunicaciones - Departament de Comunicacions, Universitat Politècnica de València. Instituto de Investigación para la Gestión Integral de Zonas Costeras - Institut d'Investigació per a la Gestió Integral de Zones Costaneres, University of Malaya, Kuala Lumpur, Modares, Hero, Moravejosharieh, Amirhossein, Lloret, Jaime, Salleh, Rosli, Universitat Politècnica de València. Departamento de Comunicaciones - Departament de Comunicacions, Universitat Politècnica de València. Instituto de Investigación para la Gestión Integral de Zonas Costeras - Institut d'Investigació per a la Gestió Integral de Zones Costaneres, University of Malaya, Kuala Lumpur, Modares, Hero, Moravejosharieh, Amirhossein, Lloret, Jaime, and Salleh, Rosli
Abstract: [EN] Mobile IPv6, also known as MIPv6, is an IP-layer protocol that offers mobility support. The MIPv6 protocol allows Mobile Nodes (MNs) to remain connected to Correspondent Nodes (CNs), even when moving to foreign networks. Basically, MNs may change their position throughout the IPv6 network while retaining their existing connections by managing address variations in the Internet layer. Numerous advantages are thus attained, but security remains a fundamental concern. According to our research, a number of protocols can form a secure connection environment between MNs and CNs, though each has advantages and disadvantages. This paper presents a state-of-the art survey of security protocols in MIPv6. Moreover, we propose taxonomy, and comparative study that does not exist in the surveys in the literature. Along with the location management feature within these protocols, potential attacks and security threats, together with the security services and requirements are necessary for minimizing such problems, are subsequently presented. (C) 2013 Elsevier Ltd. All rights reserved.
Published: 2014

5. Enhancing security in mobile IPv6

Author: Universitat Politècnica de València. Departamento de Comunicaciones - Departament de Comunicacions, University of Malaya, Kuala Lumpur, Modares, Hero, Moravejosharieh, Amirhossein, Bin Salleh, Rosli, Lloret, Jaime, Universitat Politècnica de València. Departamento de Comunicaciones - Departament de Comunicacions, University of Malaya, Kuala Lumpur, Modares, Hero, Moravejosharieh, Amirhossein, Bin Salleh, Rosli, and Lloret, Jaime
Abstract: In the Mobile IPv6 (MIPv6) protocol, a mobile node (MN) is a mobile device with a permanent home address (HoA) on its home link. The MN will acquire a care-of address (CoA) when it roams into a foreign link. It then sends a binding update (BU) message to the home agent (HA) and the correspondent node (CN) to inform them of its current CoA so that future data packets destined for its HoA will be forwarded to the CoA. The BU message, however, is vulnerable to different types of security attacks, such as the man-in-the-middle attack, the session hijacking attack, and the denial-of-service attack. The current security protocols in MIPv6 are not able to effectively protect the BU message against these attacks. The private-key-based BU (PKBU) protocol is proposed in this research to overcome the shortcomings of some existing MIPv6 protocols. PKBU incorporates a method to assert the address ownership of the MN, thus allowing the CN to validate that the MN is not a malicious node. The results obtained show that it addresses the security requirements while being able to check the address ownership of the MN. PKBU also incorporates a method to verify the reachability of the MN.
Published: 2014

6. Intention to Use Green IT among Students

Author: University of Malaya, Kuala Lumpur, Guan Choon, Tho; Faculty of Business and Accountancy, University of Malaya, Malaysia, Sulaiman, Ainin; Faculty of Business and Accountancy, University of Malaya, Malaysia, Mallasi, Hisham; Faculty of Business and Accountancy, University of Malaya, Malaysia, University of Malaya, Kuala Lumpur, Guan Choon, Tho; Faculty of Business and Accountancy, University of Malaya, Malaysia, Sulaiman, Ainin; Faculty of Business and Accountancy, University of Malaya, Malaysia, and Mallasi, Hisham; Faculty of Business and Accountancy, University of Malaya, Malaysia
Abstract: This research incorporates the Theory of planned behavior and Personality theory to examine factors influencing Green IT adoption by Malaysian students. The 5 variables from TPB, namely attitude towards Green IT, subjective norms toward Green IT, perceived behavioral control towards Green IT, intention to use Green IT behaviors and actual Green IT behavior. From the Personality theory, two variables i.e. consideration of future consequences and openness to experience were included. Empirical data was collected from 542 valid questionnaires. The results reveal that, all the variables influence the adoption of Green IT however attitude towards Green IT shows the strongest effect on intention to Green IT adoption while experience shows the weakness effect.
Published: 2014

7. Security Overview of Wireless Sensor Network

Author: Universitat Politècnica de València. Departamento de Comunicaciones - Departament de Comunicacions, Universitat Politècnica de València. Instituto de Investigación para la Gestión Integral de Zonas Costeras - Institut d'Investigació per a la Gestió Integral de Zones Costaneres, University of Malaya, Kuala Lumpur, Modares, Hero, Moravejosharieh, Amirhossein, Salleh, Rosli, Lloret, Jaime, Universitat Politècnica de València. Departamento de Comunicaciones - Departament de Comunicacions, Universitat Politècnica de València. Instituto de Investigación para la Gestión Integral de Zonas Costeras - Institut d'Investigació per a la Gestió Integral de Zones Costaneres, University of Malaya, Kuala Lumpur, Modares, Hero, Moravejosharieh, Amirhossein, Salleh, Rosli, and Lloret, Jaime
Abstract: [EN] There are several types of security threats that can give rise to vulnerability issues and performance degradation for the Wireless Sensor Network (WSN). The existing protocols that incorporate security features for authentication, key management, and secure routing, have not able to protect the WSN, effectively but a new Intrusion Detection System (IDS) can overcome these problems. The IDS collects data for analysis in order to identify any abnormal behaviour at the sensor nodes, which if present, could indicate an attack on the network. Many different intrusion detection systems for wireless sensor networks have been proposed in the past years. This paper focuses on the security requirements, layering-based attacks, and intrusion detection in WSN.
Published: 2013

8. APPLICATION OF MODEL PREDICTIVE CONTROL TO BATCH POLYMERIZATION REACTOR

Author: Ghasem, N. M.; Department of Chemical Engineering, University of Malaya, Kuala Lumpur, Malaysia, Hussain, M. A.; Department of Chemical Engineering, University of Malaya, Kuala Lumpur, Malaysia, Sata, S. A.; Department of Chemical Engineering, University of Malaya, Kuala Lumpur, Malaysia, Ghasem, N. M.; Department of Chemical Engineering, University of Malaya, Kuala Lumpur, Malaysia, Hussain, M. A.; Department of Chemical Engineering, University of Malaya, Kuala Lumpur, Malaysia, and Sata, S. A.; Department of Chemical Engineering, University of Malaya, Kuala Lumpur, Malaysia

9. APPLICATION OF MODEL PREDICTIVE CONTROL TO BATCH POLYMERIZATION REACTOR

Author: Ghasem, N. M.; Department of Chemical Engineering, University of Malaya, Kuala Lumpur, Malaysia, Hussain, M. A.; Department of Chemical Engineering, University of Malaya, Kuala Lumpur, Malaysia, Sata, S. A.; Department of Chemical Engineering, University of Malaya, Kuala Lumpur, Malaysia, Ghasem, N. M.; Department of Chemical Engineering, University of Malaya, Kuala Lumpur, Malaysia, Hussain, M. A.; Department of Chemical Engineering, University of Malaya, Kuala Lumpur, Malaysia, and Sata, S. A.; Department of Chemical Engineering, University of Malaya, Kuala Lumpur, Malaysia

10. APPLICATION OF MODEL PREDICTIVE CONTROL TO BATCH POLYMERIZATION REACTOR

Author: Ghasem, N. M.; Department of Chemical Engineering, University of Malaya, Kuala Lumpur, Malaysia, Hussain, M. A.; Department of Chemical Engineering, University of Malaya, Kuala Lumpur, Malaysia, Sata, S. A.; Department of Chemical Engineering, University of Malaya, Kuala Lumpur, Malaysia, Ghasem, N. M.; Department of Chemical Engineering, University of Malaya, Kuala Lumpur, Malaysia, Hussain, M. A.; Department of Chemical Engineering, University of Malaya, Kuala Lumpur, Malaysia, and Sata, S. A.; Department of Chemical Engineering, University of Malaya, Kuala Lumpur, Malaysia
Abstract: The absence of a stable operational state in polymerization reactors that operates in batches is factor that determine the need of a special control system. In this study, advanced control methodology is implemented for controlling the operation of a batch polymerization reactor for polystyrene production utilizing model predictive control. By utilizing a model of the polymerization process, the necessary operational conditions were determined for producing the polymer within the desired characteristics. The main control objective is to bring the reactor temperature to its target temperature as rapidly as possible with minimal temperature overshoot. Control performance for the proposed method is encouraging. It has been observed that temperature overshoot can be minimized by the proposed method with the use of both reactor and jacket energy balance for reactor temperature control.

11. Editor's note.

Author: Goh Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia, KL
Subjects: COVID-19, PUBLIC health
Published: 2020
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12. Frontal Electroencephalogram Alpha Asymmetry during Mental Stress Related to Workplace Noise

Author: Emad Alyan, Mohd Zuki Yusoff, Frédéric Merienne, Nidal Kamel, Mohammad Abdul Rahman, Naufal M. Saad, Mohd Azman Zakariya, Christophe Guillet, Centre for Intelligent Signal and Imaging Research [Petronas] (CISIR), Universiti Teknologi PETRONAS (UTP), Department of Electrical & Electronics Engineering [Petronas], Faculty of Engineering [Petronas], Universiti Teknologi PETRONAS (UTP)-Universiti Teknologi PETRONAS (UTP), Faculty of Medicine, University of Malaya [Kuala Lumpur, Malaisie], University of Malaya [Kuala Lumpur, Malaisie], Laboratoire d’Ingénierie des Systèmes Physiques et Numériques (LISPEN), Arts et Métiers Sciences et Technologies, HESAM Université (HESAM)-HESAM Université (HESAM), and Ministry of Higher Education Malaysia under the Higher Institutional Centre of Excellence (HICoE) Scheme
Subjects: medicine.medical_specialty, Brain activity and meditation, Alpha (ethology), Electroencephalography, Audiology, lcsh:Chemical technology, Biochemistry, Prefrontal cortex, Article, 050105 experimental psychology, Noise stress, Analytical Chemistry, Traitement du signal et de l'image [Informatique], Salivary alpha-amylase, 03 medical and health sciences, 0302 clinical medicine, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, Stress (linguistics), medicine, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, Humans, Imagerie médicale [Informatique], lcsh:TP1-1185, Attention, 0501 psychology and cognitive sciences, Electrical and Electronic Engineering, Workplace, EEG alpha-asymmetry, Instrumentation, medicine.diagnostic_test, 05 social sciences, Cognition, Atomic and Molecular Physics, and Optics, Electroencephalogram (EEG), Frontal Lobe, Alpha Rhythm, Noise, QUIET, Psychology, Stress, Psychological, 030217 neurology & neurosurgery
Abstract: This study aims to investigate the effects of workplace noise on neural activity and alpha asymmetries of the prefrontal cortex (PFC) during mental stress conditions. Workplace noise exposure is a pervasive environmental pollutant and is negatively linked to cognitive effects and selective attention. Generally, the stress theory is assumed to underlie the impact of noise on health. Evidence for the impacts of workplace noise on mental stress is lacking. Fifteen healthy volunteer subjects performed the Montreal imaging stress task in quiet and noisy workplaces while their brain activity was recorded using electroencephalography. The salivary alpha-amylase (sAA) was measured before and immediately after each tested workplace to evaluate the stress level. The results showed a decrease in alpha rhythms, or an increase in cortical activity, of the PFC for all participants at the noisy workplace. Further analysis of alpha asymmetry revealed a greater significant relative right frontal activation of the noisy workplace group at electrode pairs F4-F3 but not F8-F7. Furthermore, a significant increase in sAA activity was observed in all participants at the noisy workplace, demonstrating the presence of stress. The findings provide critical information on the effects of workplace noise-related stress that might be neglected during mental stress evaluations. Ministry of Higher Education Malaysia under the Higher Institutional Centre of Excellence (HICoE) Scheme
Published: 2021
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13. Polygenic risk scores and breast and epithelial ovarian cancer risks for carriers of BRCA1 and BRCA2 pathogenic variants

Author: Daniel R. Barnes, Matti A. Rookus, Lesley McGuffog, Goska Leslie, Thea M. Mooij, Joe Dennis, Nasim Mavaddat, Julian Adlard, Munaza Ahmed, Kristiina Aittomäki, Nadine Andrieu, Irene L. Andrulis, Norbert Arnold, Banu K. Arun, Jacopo Azzollini, Judith Balmaña, Rosa B. Barkardottir, Daniel Barrowdale, Javier Benitez, Pascaline Berthet, Katarzyna Białkowska, Amie M. Blanco, Marinus J. Blok, Bernardo Bonanni, Susanne E. Boonen, Åke Borg, Aniko Bozsik, Angela R. Bradbury, Paul Brennan, Carole Brewer, Joan Brunet, Saundra S. Buys, Trinidad Caldés, Maria A. Caligo, Ian Campbell, Lise Lotte Christensen, Wendy K. Chung, Kathleen B.M. Claes, Chrystelle Colas, Marie-Agnès Collonge-Rame, Capucine Delnatte, Laurence Faivre, Sophie Giraud, Christine Lasset, Véronique Mari, Noura Mebirouk, Emmanuelle Mouret-Fourme, Hélène Schuster, Dominique Stoppa-Lyonnet, Antonis Antoniou, Jackie Cook, Rosemarie Davidson, Douglas Easton, Ros Eeles, D. Gareth Evans, Debra Frost, Helen Hanson, Louise Izatt, Kai-ren Ong, Lucy Side, Aoife O’Shaughnessy-Kirwan, Marc Tischkowitz, Lisa Walker, Mary B. Daly, Miguel de la Hoya, Robin de Putter, Peter Devilee, Orland Diez, Yuan Chun Ding, Susan M. Domchek, Cecilia M. Dorfling, Martine Dumont, Bent Ejlertsen, Christoph Engel, Lenka Foretova, Florentia Fostira, Michael Friedlander, Eitan Friedman, Patricia A. Ganz, Judy Garber, Andrea Gehrig, Anne-Marie Gerdes, Paul Gesta, Gord Glendon, Andrew K. Godwin, David E. Goldgar, Anna González-Neira, Mark H. Greene, Daphne Gschwantler-Kaulich, Eric Hahnen, Ute Hamann, Julia Hentschel, Frans B.L. Hogervorst, Maartje J. Hooning, Judit Horvath, Chunling Hu, Peter J. Hulick, Evgeny N. Imyanitov, Georgia Chenevix-Trench, Kelly-Anne Phillips, Amanda Spurdle, Marinus Blok, Frans Hogervorst, Maartje Hooning, Marco Koudijs, Arjen Mensenkamp, Hanne Meijers-Heijboer, Matti Rookus, Klaartje van Engelen, Catherine Noguès, Claudine Isaacs, Angel Izquierdo, Anna Jakubowska, Paul A. James, Ramunas Janavicius, Esther M. John, Vijai Joseph, Beth Y. Karlan, Karin Kast, Torben A. Kruse, Ava Kwong, Yael Laitman, Conxi Lazaro, Jenny Lester, Fabienne Lesueur, Annelie Liljegren, Jennifer T. Loud, Jan Lubiński, Phuong L. Mai, Siranoush Manoukian, Hanne E.J. Meijers-Heijboer, Alfons Meindl, Arjen R. Mensenkamp, Austin Miller, Marco Montagna, Semanti Mukherjee, Anna Marie Mulligan, Katherine L. Nathanson, Susan L. Neuhausen, Heli Nevanlinna, Dieter Niederacher, Finn Cilius Nielsen, Liene Nikitina-Zake, Edith Olah, Olufunmilayo I. Olopade, Ana Osorio, Claus-Eric Ott, Laura Papi, Sue K. Park, Michael T. Parsons, Inge Sokilde Pedersen, Bernard Peissel, Ana Peixoto, Paolo Peterlongo, Georg Pfeiler, Karolina Prajzendanc, Miquel Angel Pujana, Paolo Radice, Juliane Ramser, Susan J. Ramus, Johanna Rantala, Gad Rennert, Harvey A. Risch, Mark Robson, Karina Rønlund, Ritu Salani, Leigha Senter, Payal D. Shah, Priyanka Sharma, Lucy E. Side, Christian F. Singer, Thomas P. Slavin, Penny Soucy, Melissa C. Southey, Amanda B. Spurdle, Doris Steinemann, Zoe Steinsnyder, Christian Sutter, Yen Yen Tan, Manuel R. Teixeira, Soo Hwang Teo, Darcy L. Thull, Silvia Tognazzo, Amanda E. Toland, Alison H. Trainer, Nadine Tung, Elizabeth J. van Rensburg, Ana Vega, Jeroen Vierstraete, Gabriel Wagner, Shan Wang-Gohrke, Barbara Wappenschmidt, Jeffrey N. Weitzel, Siddhartha Yadav, Xin Yang, Drakoulis Yannoukakos, Dario Zimbalatti, Kenneth Offit, Mads Thomassen, Fergus J. Couch, Rita K. Schmutzler, Jacques Simard, Douglas F. Easton, Antonis C. Antoniou, Pediatric surgery, Human genetics, CCA - Cancer biology and immunology, CCA - Cancer Treatment and quality of life, Amsterdam Reproduction & Development (AR&D), Apollo - University of Cambridge Repository, University of Cambridge [UK] (CAM), Netherlands Cancer Institute (NKI), Antoni van Leeuwenhoek Hospital, Chapel Allerton Hospital, Great Ormond Street Hospital for Children [London] (GOSH), Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Cancer et génome: Bioinformatique, biostatistiques et épidémiologie d'un système complexe, Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Curie [Paris], Université Paris sciences et lettres (PSL), Mount Sinai Hospital [Toronto, Canada] (MSH), University of Toronto (University of Toronto), Christian-Albrechts University of Kiel, The University of Texas M.D. Anderson Cancer Center [Houston], Fondazione IRCCS Istituto Nazionale Tumori - National Cancer Institute [Milan], Vall d'Hebron Institute of Oncology [Barcelone] (VHIO), Vall d'Hebron University Hospital [Barcelona], Landspitali National University Hospital of Iceland, University of Iceland [Reykjavik], CIBER de Enfermedades Raras (CIBERER), Spanish National Cancer Research Center (CNIO), Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), Normandie Université (NU)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN), Pomeranian Medical University [Szczecin] (PUM), University of California (UC), Maastricht University Medical Centre (MUMC), Maastricht University [Maastricht], European Institute of Oncology IRCCS [Milan, Italy] (EIO), Zealand University Hospital [Roskilde, Denmark], Lund University [Lund], National Institute of Oncology [Budapest, Hungary], Abramson Cancer Center [philadelphia], University of Pennsylvania-Perelman School of Medicine, University of Pennsylvania, Institute of Genetic Medicine [Newcastle], Newcastle University [Newcastle], Royal Devon & Exeter Hospital, Exeter, UK, Catalan Institute of Oncology [Barcelone, Espagne], Huntsman Cancer Institute [Salt Lake City], University of Utah, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos [Madrid, Spain] (IdISSC), Pisa University Hospital, Peter MacCallum Cancer Centre [Melbourne, Australie], University of Melbourne, Aarhus University Hospital, Columbia University [New York], Ghent University Hospital, Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Sheffield Children's NHS Foundation Trust, Fox Chase Cancer Center, Queen Elizabeth University Hospital (Glasgow), Centre hospitalier universitaire de Nantes (CHU Nantes), Leiden University Medical Center (LUMC), Beckman Research Institute of the City of Hope, Abramson Cancer Center, University of Pretoria [South Africa], Centre Hospitalier Universitaire de Québec Research Center [Canada], Royal Marsden NHS Foundation Trust, Copenhagen University Hospital, Leipzig University, University of Manchester [Manchester], Manchester Academic Health Science Centre (MAHSC), Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] (UNICANCER/CRLCC-CGFL), UNICANCER, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Masaryk Memorial Cancer Institute (MMCI), Institute of Nuclear and Radiological Sciences and Technology, Energy and Safety (INRASTES), National Center for Scientific Research 'Demokritos' (NCSR), NHMRC Clinical Trials Centre [Camperdown NSW 2050, Australie], Chaim Sheba Medical Center, Tel Aviv University (TAU), Jonsson Comprehensive Cancer Center, University of California [Los Angeles] (UCLA), University of California (UC)-University of California (UC), Dana-Farber Cancer Institute [Boston], University of Würzburg, Rigshospitalet [Copenhagen], Centre Hospitalier Georges Renon [Niort] (CH Georges Renon Niort), Hospices Civils de Lyon (HCL), University of Kansas [Kansas City], National Cancer Institute [Bethesda] (NCI-NIH), National Institutes of Health [Bethesda] (NIH), Medizinische Universität Wien = Medical University of Vienna, University of Cologne, German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), Lancashire NHS Foundation Trust, University Hospital Leipzig, Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center [Rotterdam] (Erasmus MC), Westfälische Wilhelms-Universität Münster = University of Münster (WWU), Mayo Clinic, NorthShore University HealthSystem [Evanston, IL, USA], The University of Chicago Medicine [Chicago], N. N. Petrov Institute of Oncology, Georgetown Lombardi Comprehensive Cancer Center, Guy's and St Thomas' NHS Foundation Trust [London, UK], Peter MacCallum Cancer Center, East Melbourne, Peter MacCallum Cancer Center, Vilnius University [Vilnius], The State Scientific Research Institute Nature Research Centre, Vilnius, Lithuania, Stanford University School of Medicine [CA, USA], Memorial Sloane Kettering Cancer Center [New York], Cedars-Sinai Medical Center, Technische Universität Dresden = Dresden University of Technology (TU Dresden), University Medical Center [Utrecht], Odense University Hospital [Odense, Denmark], The Hong Kong Hereditary Breast Cancer Family Registry, The University of Hong Kong (HKU), Hong Kong Sanatorium and Hospital [Hong Kong] (HKSH), Equipe de prévention et épidémiologie génétique, Centre Léon Bérard [Lyon], Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), David Geffen School of Medicine [Los Angeles], Fondation MINES ParisTech, Karolinska Institutet [Stockholm], University of Pittsburgh School of Medicine, Pennsylvania Commonwealth System of Higher Education (PCSHE), Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] (UNICANCER/CAL), UNICANCER-Université Côte d'Azur (UCA), Amsterdam UMC - Amsterdam University Medical Center, Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM), Radboud University Medical Center [Nijmegen], Roswell Park Cancer Institute [Buffalo], Veneto Institute of Oncology IOV-IRCCS [Padua, Italy], University of Toronto, University Health Network, University Hospital Düsseldorf, Latvian Biomedical Research and Study Centre [Rīga], Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC), University of Chicago, Birmingham Women's and Children's NHS Foundation Trust, Cambridge University Hospitals - NHS (CUH), Charité Campus Virchow-Klinikum (CVK), Università degli Studi di Firenze = University of Florence (UniFI), Seoul National University College of Medicine [Séoul, Corée du Sud] (SNUCM), Seoul National University [Seoul] (SNU), QIMR Berghofer Medical Research Institute, Aalborg University [Denmark] (AAU), IRCCS Istituto Nazionale dei Tumori [Milano], Instituto Português de Oncologia do Porto / Portuguese Oncology Institute of Porto (IPO Porto), IFOM, Istituto FIRC di Oncologia Molecolare (IFOM), Institut d'Investigació Biomèdica de Bellvitge [Barcelone] (IDIBELL), Klinikum rechts der Isar [Munich, Germany], University of New South Wales [Sydney] (UNSW), Garvan Institute of medical research, Technion Faculty of Medicine [Haifa, Israel], Yale School of Medicine [New Haven, Connecticut] (YSM), Vejle Hospital [Danemark], Ohio State University [Columbus] (OSU), Centre de lutte contre le cancer Paul-Strauss, Institut de Cancérologie de Strasbourg Europe (ICANS), Immuno-Rhumatologie Moléculaire, Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Kansas Medical Center [Kansas City, KS, USA], Princess Anne Hospital, City of Hope Comprehensive Cancer Center [Duarte], Monash University [Clayton], Cancer Council Victoria [Melbourne, VIC, Australia], Hannover Medical School [Hannover] (MHH), Unité de génétique et biologie des cancers (U830), Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris Descartes - Paris 5 (UPD5), Heidelberg University Hospital [Heidelberg], Institute of Biomedical Sciences Abel Salazar - ICBAS [Porto, Portugal], Malaysia and University Malaya Cancer Research Institute, Faculty of Medicine, University of Malaya [Kuala Lumpur, Malaisie], University of Malaya = Universiti Malaya [Kuala Lumpur, Malaisie] (UM), McGill University = Université McGill [Montréal, Canada], Beth Israel Deaconess Medical Center [Boston] (BIDMC), Harvard Medical School [Boston] (HMS), Fundación Pública Galega Medicina Xenómica - SERGAS [Santiago de Compostela, Spain] (Grupo de Medicina Xenómica), CIBER de Enfermedades Raras (CIBERER)-Universidade de Santiago de Compostela [Spain] (USC ), Instituto de Investigaciones Sanitarias, Universidade de Santiago de Compostela [Spain] (USC ), Universiteit Gent = Ghent University (UGENT), Oxford University Hospitals NHS Trust, University of Oxford, Universitätsklinikum Ulm - University Hospital of Ulm, University Hospital of Cologne [Cologne], Mayo Clinic [Rochester], Collaborators : Pascaline Berthet, Chrystelle Colas, Marie-Agnès Collonge-Rame, Capucine Delnatte, Laurence Faivre, Sophie Giraud, Christine Lasset, Véronique Mari, Noura Mebirouk, Emmanuelle Mouret-Fourme, Hélène Schuster, Dominique Stoppa-Lyonnet, Julian Adlard, Munaza Ahmed, Antonis Antoniou, Daniel Barrowdale, Paul Brennan, Carole Brewer, Jackie Cook, Rosemarie Davidson, Douglas Easton, Ros Eeles, D Gareth Evans, Debra Frost, Helen Hanson, Louise Izatt, Kai-Ren Ong, Lucy Side, Aoife O'Shaughnessy-Kirwan, Marc Tischkowitz, Lisa Walker, Georgia Chenevix-Trench, Kelly-Anne Phillips, Amanda Spurdle, Marinus Blok, Peter Devilee, Frans Hogervorst, Maartje Hooning, Marco Koudijs, Arjen Mensenkamp, Hanne Meijers-Heijboer, Matti Rookus, Klaartje van Engelen, Nadine Andrieu, Catherine Noguès, Dupuis, Christine, Institut Català de la Salut, [Barnes DR, McGuffog L, Leslie G, Dennis J] Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. [Rookus MA, Mooij TM] The Netherlands Cancer Institute, Department of Epidemiology (PSOE), Amsterdam, The Netherlands. [Balmaña J] High Risk and Cancer Prevention Group, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Servei d’Oncologia Mèdica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Diez O] Oncogenetics Group, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Àrea de Genètica Clínica i Molecular, Vall d’Hebron Hospital Universitari, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus, Barnes, Daniel [0000-0002-3781-7570], Leslie, Goska [0000-0001-5756-6222], Dennis, Joe [0000-0003-4591-1214], Mavaddat, Nasim [0000-0003-0307-055X], RS: GROW - R4 - Reproductive and Perinatal Medicine, MUMC+: DA KG Lab Centraal Lab (9), Universiteit Leiden, Roswell Park Cancer Institute [Buffalo] (RPCI), Medical Oncology, Medicum, Kristiina Aittomäki / Principal Investigator, HUSLAB, Department of Medical and Clinical Genetics, Helsinki University Hospital Area, Department of Obstetrics and Gynecology, Biosciences, HUS Gynecology and Obstetrics, University of Helsinki, Institut Curie [Paris]-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM), MINES ParisTech - École nationale supérieure des mines de Paris, UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU), Pomeranian Medical University, University of California, University of Pennsylvania [Philadelphia]-Perelman School of Medicine, University of Pennsylvania [Philadelphia], University of Leipzig [Leipzig, Allemagne], Masaryk Memorial Cancer Institute (RECAMO), Tel Aviv University [Tel Aviv], University of California-University of California, University of Münster, Amsterdam UMC, Technical University of Munich (TUM), Università degli Studi di Firenze = University of Florence [Firenze] (UNIFI), Garvan Institute of Medical Research [Sydney, Australia], Yale University School of Medicine, Vejle Hospital, University of Kansas Medical Center [Lawrence], Université Paris Descartes (Paris 5), University of Malaya [Kuala Lumpur, Malaisie], Universiteit Gent = Ghent University [Belgium] (UGENT), and University of Oxford [Oxford]
Subjects: 0301 basic medicine, Oncology, endocrine system diseases, Neoplasms::Neoplasms by Site::Breast Neoplasms [DISEASES], [SDV]Life Sciences [q-bio], Càncer d'ovari, Genetic Phenomena::Genotype::Genetic Predisposition to Disease [PHENOMENA AND PROCESSES], MODIFIERS, Diàtesi, SUSCEPTIBILITY, Carcinoma, Ovarian Epithelial, PRS, 0302 clinical medicine, Breast cancer, 3123 Gynaecology and paediatrics, Risk Factors, Medicine and Health Sciences, Medicine, Genetics(clinical), genetics, Prospective Studies, Prospective cohort study, skin and connective tissue diseases, Genetics (clinical), Ovarian Neoplasms, education.field_of_study, neoplasias::neoplasias por localización::neoplasias de la mama [ENFERMEDADES], Women's cancers Radboud Institute for Molecular Life Sciences [Radboudumc 17], BRCA1 Protein, Hazard ratio, Absolute risk reduction, 1184 Genetics, developmental biology, physiology, article, ASSOCIATION, neoplasias::neoplasias::neoplasias por localización::neoplasias de las glándulas endocrinas::neoplasias ováricas::carcinoma epitelial de ovario [ENFERMEDADES], ddc, 3. Good health, [SDV] Life Sciences [q-bio], ovarian cancer, 030220 oncology & carcinogenesis, Female, Cohort study, medicine.medical_specialty, Heterozygote, Population, 3122 Cancers, Single-nucleotide polymorphism, Breast Neoplasms, MUTATION CARRIERS, Ovaris - Càncer - Aspectes genètics, Càncer de mama, 03 medical and health sciences, breast cancer, SDG 3 - Good Health and Well-being, Ovarian cancer, BRCA1/2, Internal medicine, Humans, Genetic Predisposition to Disease, education, Retrospective Studies, fenómenos genéticos::genotipo::predisposición genética a la enfermedad [FENÓMENOS Y PROCESOS], BRCA2 Protein, IDENTIFICATION, business.industry, Neoplasms::Neoplasms::Neoplasms by Site::Endocrine Gland Neoplasms::Ovarian Neoplasms::Carcinoma, Ovarian Epithelial [DISEASES], Retrospective cohort study, ALLELES, medicine.disease, BRCA1, BRCA2, MODEL, PATHOLOGY, 030104 developmental biology, Mutation, Mama - Càncer - Aspectes genètics, 3111 Biomedicine, business
Abstract: Contains fulltext : 229292.pdf (Publisher’s version ) (Open Access) PURPOSE: We assessed the associations between population-based polygenic risk scores (PRS) for breast (BC) or epithelial ovarian cancer (EOC) with cancer risks for BRCA1 and BRCA2 pathogenic variant carriers. METHODS: Retrospective cohort data on 18,935 BRCA1 and 12,339 BRCA2 female pathogenic variant carriers of European ancestry were available. Three versions of a 313 single-nucleotide polymorphism (SNP) BC PRS were evaluated based on whether they predict overall, estrogen receptor (ER)-negative, or ER-positive BC, and two PRS for overall or high-grade serous EOC. Associations were validated in a prospective cohort. RESULTS: The ER-negative PRS showed the strongest association with BC risk for BRCA1 carriers (hazard ratio [HR] per standard deviation = 1.29 [95% CI 1.25-1.33], P = 3×10(-72)). For BRCA2, the strongest association was with overall BC PRS (HR = 1.31 [95% CI 1.27-1.36], P = 7×10(-50)). HR estimates decreased significantly with age and there was evidence for differences in associations by predicted variant effects on protein expression. The HR estimates were smaller than general population estimates. The high-grade serous PRS yielded the strongest associations with EOC risk for BRCA1 (HR = 1.32 [95% CI 1.25-1.40], P = 3×10(-22)) and BRCA2 (HR = 1.44 [95% CI 1.30-1.60], P = 4×10(-12)) carriers. The associations in the prospective cohort were similar. CONCLUSION: Population-based PRS are strongly associated with BC and EOC risks for BRCA1/2 carriers and predict substantial absolute risk differences for women at PRS distribution extremes.
Published: 2020
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14. Expression of p53 N-terminal isoforms in B-cell precursor acute lymphoblastic leukemia and its correlation with clinicopathological profiles

Author: Hany Ariffin, Lixian Oh, Sandrine Blanchet, Pierre Hainaut, Faculty of Medicine, University of Malaya [Kuala Lumpur, Malaisie], University of Malaya [Kuala Lumpur, Malaisie], Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire [Grenoble] (CHU)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), This work was supported by the University Malaya Research Grant (UMRG) (RP049B-17HTM) in University Malaya, Malaysia and by INCa Grant PLBIO16–271 ‘p53 Metabolism’ at IAB Grenoble, France., Bodescot, Myriam, University of Malaya = Universiti Malaya [Kuala Lumpur, Malaisie] (UM), and Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)
Subjects: 0301 basic medicine, Gene isoform, Protein isoform, Male, Cancer Research, Oncogene Proteins, Fusion, [SDV.CAN]Life Sciences [q-bio]/Cancer, Biology, medicine.disease_cause, [SDV.BBM.BM] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, lcsh:RC254-282, p53 tumour suppressor protein, 03 medical and health sciences, Childhood ALL, 0302 clinical medicine, Western blot, [SDV.CAN] Life Sciences [q-bio]/Cancer, Recurrence, Cell Line, Tumor, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma, Genetics, medicine, Biomarkers, Tumor, Humans, Protein Interaction Domains and Motifs, RNA, Messenger, Gene, Protein isoforms, B cell, Messenger RNA, Mutation, medicine.diagnostic_test, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Molecular biology, Gene Expression Regulation, Neoplastic, 030104 developmental biology, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Female, Bone marrow, Protein Multimerization, Tumor Suppressor Protein p53, Research Article
Abstract: BackgroundTP53mutations occur in only about 3% of primary and 10–20% of relapse B-cell precursor acute lymphoblastic leukaemia (BCP-ALL). However, alternative mechanisms may contribute to functionally impairing the p53 pathway in the absence of a mutation. Candidate mechanisms include overexpression of p53 mRNA variants encoding either dominant-negative p53 protein isoforms such as Delta40p53 and Delta133p53, or modulatory isoforms such as p53beta, which counteract the effects of Delta133p53 on replicative senescence in T-lymphocytes.MethodsWe used semi-quantitative reverse-transcriptase PCR (RT-PCR) and Western blot to investigate the expression of full length p53 (TAp53), Delta40p53, Delta133p53 or p53beta in diagnostic marrow from a clinical cohort of 50 BCP-ALL patients withoutTP53mutation (29 males and 21 females, age range 2–14 years) and in the bone marrow cells of 4 healthy donors (used as controls).ResultsIrrespective of isoforms, levels of p53 mRNA were low in controls but were increased by 2 to 20-fold in primary or relapse BCP-ALL. TAp53 was increased in primary BCP-ALL, Delta40p53 was elevated in relapse BCP-ALL, whereas Delta133p53 and p53beta were increased in both. Next, mRNA levels were used as a basis to infer the ratio between protein isoform levels. This inference suggested that, in primary BCP-ALL, p53 was predominantly in active oligomeric conformations dominated by TAp53. In contrast, p53 mostly existed in inactive quaternary conformations containing ≥2 Delta40 or Delta133p53 in relapse BCP-ALL. Western blot analysis of blasts from BCP-ALL showed a complex pattern of N-terminally truncated p53 isoforms, whereas TAp53beta was detected as a major isoform. The hypothesis that p53 is in an active form in primary B-ALL was consistent with elevated level of p53 target genesCDKN1AandMDM2in primary cases, whereas in relapse BCP-ALL, onlyCDKN1Awas increased as compared to controls.ConclusionExpression of p53 isoforms is deregulated in BCP-ALL in the absence ofTP53mutation, with increased expression of alternative isoforms in relapse BCP-ALL. Variations in isoform expression may contribute to functional deregulation of the p53 pathway in BCP-ALL, specifically contributing to its down-regulation in relapse forms.
Published: 2020
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15. Immunological history governs human stem cell memory CD4 heterogeneity via the Wnt signaling pathway

Author: Ezequiel Ruiz-Mateos, Naomi Mc Govern, Bernett Lee, Tamas Fulop, Karolina Pilipow, Tze Pin Ng, Crystal Tze Ying Tan, Shu Wen Tan, Reena Rajasuriar, Hartmut Geiger, Wilson How, Mai Chan Lau, Benoit Malleret, Amanda Amoah, Florent Ginhoux, Marie Strickland, Jin Miao Chen, Maria Carolina Florian, Glenn Wong, Enrico Lugli, Adeeba Kamarulzaman, Marion Chevrier, Veronica Zanon, Hassen Kared, Anis Larbi, Josephine Lum, [Kared,H, Tan,SW, Lau,MC, Chevrier,M, Tan,C, How,W, Wong,G, Strickland,M, Malleret,B, Govern,NM, Lum,J, Chen,JM, Lee,B, Ginhoux,F, Larbi,A] Singapore Immunology Network (SIgN), Agency for Science Technology and Research (A*STAR), Immunos Building, Biopolis, Republic of Singapore. [Strickland,M] Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK. [Malleret,B, Larbi,A] Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore. [Amoah,A, Florian,MC, Geiger,H] Institute of Molecular Medicine, University of Ulm, Ulm, Germany. [Pilipow,K, Zanon,V, Lugli,E] Humanitas Clinical and Research Center, Laboratory of Translational Immunology (LTI), Rozzano, Italy. [Geiger,H] Experimental Hematology and Cancer Biology, CCHMC, Cincinnati, OH, USA. [Ruiz-Mateos,E] Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain. [Fulop.T, Larbi,A] Department of Medicine, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Quebec, Canada. [Rajasuriar,R, Kamarulzaman,A] Centre of Excellence for Research in AIDS (CERiA), University of Malaya, Kuala Lumpur, Malaysia. [Rajasuriar,R] The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia. [Rajasuriar,R, Kamarulzaman,A] Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. [Ng,TP] Gerontology Research Programme and Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., The study is supported by a research grant from the Agency for Science, Technology and Research (No. 10-036), by the Singapore Immunology Network and by a Starting Grant from the European Research Council (ERC-StG-2014 PERSYST 640511 to E.L.). A.L. is a scholar of International Society for Advancement of Cytometry (ISAC). R.R. and A.K. are funded by the High Impact Research/Ministry of Higher Education Research Grant, Malaysia (HIR/ MOHE, H-20001-E000001) and the RU grant (UMRG RP029-14HTM). E.R-M was supported by Consejería de Salud y Bienestar Social of Junta de Andalucía through the Nicolás Monardes Program (C-0032/17) and Fondo de Investigación Sanitaria, Instituto de Salud Carlos III, Fondos Europeos para el Desarrollo Regional, FEDER, grants PI16/ 00684, PI19/01127, RETICS, Red de Investigación en SIDA (RD16/0025/0020)., Agency for Science, Technology and Research A*STAR (Singapore), Singapore Immunology Network, European Research Council, International Society for Advancement of Cytometry, Ministry of Higher Education (Malaysia), Junta de Andalucía, Instituto de Salud Carlos III, European Commission, and Red Española de Investigación en SIDA
Subjects: 0301 basic medicine, CD4-Positive T-Lymphocytes, Aging, animal diseases, General Physics and Astronomy, HIV Infections, Signal transduction, Immunological memory, Memory T cells, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Mice, 0302 clinical medicine, Organisms::Eukaryota::Animals [Medical Subject Headings], Cytotoxic T cell, Flow cytometry, lcsh:Science, Wnt Signaling Pathway, beta Catenin, Phenomena and Processes::Chemical Phenomena::Chemical Processes::Biochemical Processes::Signal Transduction::Wnt Signaling Pathway [Medical Subject Headings], Multidisciplinary, Wnt signaling pathway, Catenins, Chemicals and Drugs::Biological Factors::Intercellular Signaling Peptides and Proteins [Medical Subject Headings], 3. Good health, Cell biology, Intercellular Signaling Peptides and Proteins, Diseases::Immune System Diseases::Immunologic Deficiency Syndromes::HIV Infections [Medical Subject Headings], Stem cell, Naive T cell, Science, T cells, Context (language use), chemical and pharmacologic phenomena, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Gene Expression Profiling [Medical Subject Headings], Thymus Gland, Biology, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, Immune system, Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Transcription Factors::beta Catenin [Medical Subject Headings], Antigen, Antigens, CD, Phenomena and Processes::Physiological Phenomena::Physiological Processes::Growth and Development::Aging [Medical Subject Headings], Anatomy::Tissues::Lymphoid Tissue::Thymus Gland [Medical Subject Headings], Cateninas, Animals, Humans, Anatomy::Hemic and Immune Systems::Immune System::Leukocytes::Leukocytes, Mononuclear::Lymphocytes::T-Lymphocytes::CD4-Positive T-Lymphocytes [Medical Subject Headings], Chemicals and Drugs::Biological Factors::Antigens [Medical Subject Headings], Anatomy::Cells::Stem Cells::Hematopoietic Stem Cells::Lymphoid Progenitor Cells::Precursor Cells, T-Lymphoid [Medical Subject Headings], Vía de señalización wnt, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice [Medical Subject Headings], Precursor Cells, T-Lymphoid, Células T de memoria, Gene Expression Profiling, General Chemistry, biochemical phenomena, metabolism, and nutrition, 030104 developmental biology, Sistema inmunológico, Phenomena and Processes::Immune System Phenomena::Immunity::Adaptive Immunity::Immunologic Memory [Medical Subject Headings], bacteria, lcsh:Q, Citometría de flujo, Immunologic Memory, 030215 immunology
Abstract: The diversity of the naïve T cell repertoire drives the replenishment potential and capacity of memory T cells to respond to immune challenges. Attrition of the immune system is associated with an increased prevalence of pathologies in aged individuals, but whether stem cell memory T lymphocytes (TSCM) contribute to such attrition is still unclear. Using single cells RNA sequencing and high-dimensional flow cytometry, we demonstrate that TSCM heterogeneity results from differential engagement of Wnt signaling. In humans, aging is associated with the coupled loss of Wnt/β-catenin signature in CD4 TSCM and systemic increase in the levels of Dickkopf-related protein 1, a natural inhibitor of the Wnt/β-catenin pathway. Functional assays support recent thymic emigrants as the precursors of CD4 TSCM. Our data thus hint that reversing TSCM defects by metabolic targeting of the Wnt/β-catenin pathway may be a viable approach to restore and preserve immune homeostasis in the context of immunological history., Aging is associated with immune attrition that may impact the effectiveness of the immune system to protect the host from pathogens. Here the authors show that immune aging is associated with alterations in the Wnt/β-catenin signaling and reduced stem cell memory T lymphocytes, hinting the Wnt/β-catenin pathway as a potential therapy target.
Published: 2020

16. Recent Emergence of Rhenium(I) Tricarbonyl Complexes as Photosensitisers for Cancer Therapy

Author: May Lee Low, Thiagarajan Madheswaran, Lik Voon Kiew, Nicolas Delsuc, Mohd Zulkefeli, Hui Shan Liew, Chun-Wai Mai, Gestionnaire, Hal Sorbonne Université, International Medical University (IMU), Faculty of Medicine, University of Malaya [Kuala Lumpur, Malaisie], University of Malaya = Universiti Malaya [Kuala Lumpur, Malaisie] (UM), Laboratoire des biomolécules (LBM UMR 7203), Chimie Moléculaire de Paris Centre (FR 2769), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Département de Chimie - ENS Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Département de Chimie - ENS Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), University of Malaya [Kuala Lumpur, Malaisie], Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Département de Chimie - ENS Paris, École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Chimie Moléculaire de Paris Centre (FR 2769), Institut de Chimie du CNRS (INC)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), and Université Paris sciences et lettres (PSL)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: medicine.medical_treatment, Pharmaceutical Science, Photodynamic therapy, Review, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, 01 natural sciences, Analytical Chemistry, Mice, rhenium(I) tricarbonyl complexes, Coordination Complexes, Neoplasms, Drug Discovery, medicinal inorganic chemistry, Photosensitizing Agents, Chemistry, Rhenium, Cancer treatment, Drug Combinations, photodynamic therapy, Chemistry (miscellaneous), Molecular Medicine, Nanomedicine, metals in medicine, Metals in medicine, [CHIM.THER] Chemical Sciences/Medicinal Chemistry, Cancer therapy, chemistry.chemical_element, Antineoplastic Agents, 010402 general chemistry, lcsh:QD241-441, lcsh:Organic chemistry, Cell Line, Tumor, medicine, Animals, Humans, cancer, [CHIM.COOR]Chemical Sciences/Coordination chemistry, Physical and Theoretical Chemistry, Photons, 010405 organic chemistry, Organic Chemistry, Photothermal therapy, [CHIM.COOR] Chemical Sciences/Coordination chemistry, photosensitisers, Combinatorial chemistry, Carbon, 0104 chemical sciences, Oxygen, Photochemotherapy, Molecular oxygen, Reactive Oxygen Species
Abstract: International audience; Photodynamic therapy (PDT) is emerging as a significant complementary or alternative approach for cancer treatment. PDT drugs act as photosensitisers, which upon using appropriate wavelength light and in the presence of molecular oxygen, can lead to cell death. Herein, we reviewed the general characteristics of the different generation of photosensitisers. We also outlined the emergence of rhenium (Re) and more specifically, Re(I) tricarbonyl complexes as a new generation of metal-based photosensitisers for photodynamic therapy that are of great interest in multidisciplinary research. The photophysical properties and structures of Re(I) complexes discussed in this review are summarised to determine basic features and similarities among the structures that are important for their phototoxic activity and future investigations. We further examined the in vitro and in vivo efficacies of the Re(I) complexes that have been synthesised for anticancer purposes. We also discussed Re(I) complexes in conjunction with the advancement of two-photon PDT, drug combination study, nanomedicine, and photothermal therapy to overcome the limitation of such complexes, which generally absorb short wavelengths.
Published: 2020
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17. 2BC Non-Structural Protein of Enterovirus A71 Interacts with SNARE Proteins to Trigger Autolysosome Formation

Author: Jeffrey K.F. Lai, I-Ching Sam, Pauline Verlhac, Mathias Faure, Eeva-Liisa Eskelinen, Joël Baguet, Yoke Fun Chan, Biosciences, Biochemistry and Biotechnology, Autophagy, Faculty of Medicine, University of Malaya [Kuala Lumpur, Malaisie], University of Malaya [Kuala Lumpur, Malaisie], Autophagie infection et immunité - Autophagy Infection Immunity (APY), Centre International de Recherche en Infectiologie - UMR (CIRI), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), HiLIFE - Institute of Biotechnology [Helsinki] (BI), Helsinki Institute of Life Science (HiLIFE), University of Helsinki-University of Helsinki, University of Malaya = Universiti Malaya [Kuala Lumpur, Malaisie] (UM), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Helsingin yliopisto = Helsingfors universitet = University of Helsinki-Helsingin yliopisto = Helsingfors universitet = University of Helsinki
Subjects: 0301 basic medicine, Picornavirus, Autolysosome, lcsh:QR1-502, Viral Nonstructural Proteins, Virus Replication, lcsh:Microbiology, Protein Interaction Mapping, HOPS COMPLEX, 1183 Plant biology, microbiology, virology, Tumor, LAMP1, Qa-SNARE Proteins, enterovirus, synaptosome-associated protein of 29 kDa, Qb-SNARE Proteins, VIRUS-REPLICATION, autolysosome, Cell biology, Infectious Diseases, enterovirus A71, SNARE, Host-Pathogen Interactions, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, [SDV.IMM]Life Sciences [q-bio]/Immunology, MACHINERY, Microtubule-Associated Proteins, Human, Protein Binding, replication, autophagy, Immunoprecipitation, Biology, Article, MATURATION, Cell Line, MECHANISMS, picornavirus, syntaxin-17, 2BC, 03 medical and health sciences, Cell Line, Tumor, Virology, Two-Hybrid System Techniques, Humans, Qc-SNARE Proteins, POLIOVIRUS REPLICATION COMPLEX, Autophagy, Lysosome-Associated Membrane Glycoproteins, biology.organism_classification, Molecular biology, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, Enterovirus A, Human, 030104 developmental biology, AUTOPHAGOSOME-LYSOSOME FUSION, Viral replication, Membrane protein, CELLS, Enterovirus A, Lysosomes, SYNTAXIN 17, INHIBITORS
Abstract: International audience; Viruses have evolved unique strategies to evade or subvert autophagy machinery. Enterovirus A71 (EV-A71) induces autophagy during infection in vitro and in vivo. In this study, we report that EV-A71 triggers autolysosome formation during infection in human rhabdomyosarcoma (RD) cells to facilitate its replication. Blocking autophagosome-lysosome fusion with chloroquine inhibited virus RNA replication, resulting in lower viral titres, viral RNA copies and viral proteins. Overexpression of the non-structural protein 2BC of EV-A71 induced autolysosome formation. Yeast 2-hybrid and co-affinity purification assays showed that 2BC physically and specifically interacted with a N-ethylmaleimide-sensitive factor attachment receptor (SNARE) protein, syntaxin-17 (STX17). Co-immunoprecipitation assay further showed that 2BC binds to SNARE proteins, STX17 and synaptosome associated protein 29 (SNAP29). Transient knockdown of STX17, SNAP29, and microtubule-associated protein 1 light chain 3B (LC3B), crucial proteins in the fusion between autophagosomes and lysosomes) as well as the lysosomal-associated membrane protein 1 (LAMP1) impaired production of infectious EV-A71 in RD cells. Collectively, these results demonstrate that the generation of autolysosomes triggered by the 2BC non-structural protein is important for EV-A71 replication, revealing a potential molecular pathway targeted by the virus to exploit autophagy. This study opens the possibility for the development of novel antivirals that specifically target 2BC to inhibit formation of autolysosomes during EV-A71 infection.
Published: 2017
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18. Solar insolation in springtime influences age of onset of bipolar I disorder

Author: Christian Simhandl, Harriet Birabwa-Oketcho, Slim Khaldi, Claire O'Donovan, Ahmad Hatim Sulaiman, Janusz K. Rybakowski, Dan J. Stein, M. S. Reddy, Rasmus Wentzer Licht, Andreas Reif, Flávio Kapczinski, Y. Pica Ruiz, Ângela Miranda Scippa, Christopher Baethge, Julia Veeh, M. Yee Ming, Kemal Sagduyu, Hiromi Tagata, Biju Viswanath, F. D. R. da Ponte, Scott Monteith, Michael Bauer, Mark A. Frye, Yamima Osher, Raffaella Ardau, Ana González-Pinto, Yoshitaka Tatebayashi, Chantal Henry, Sven Janno, M. A. Aleksandrovich, Timur L. Kot, Beny Lafer, Paul Grof, Yavuz Ayhan, René Ernst Nielsen, Barbara König, Eduard Vieta, Emanuel Severus, Erik Roj Larsen, Kirsi Suominen, Sebastian Kliwicki, Eric Yat Wo Cheung, Peter C. Whybrow, H. Østermark Sørensen, John F. Gottlieb, Mikael Landén, Michael Berk, Andrea Fagiolini, M. Del Zompo, Juan Cabrera, Carlos López-Jaramillo, Mirko Manchia, Tasha Glenn, Ingrid Melle, Starlin V. Mythri, Sule Bicakci, Rita Bauer, Maximilian Pilhatsch, Rodrigo A. Munoz, Danilo Quiroz, Glenda MacQueen, Philipp Ritter, Hirohiko Harima, Ravi Kumar Nadella, Enrica Mosca, Yuly Bersudsky, Natalie L. Rasgon, Wendy K. Marsh, Konstantinos N. Fountoulakis, María Yoldi-Negrete, Adel Omrani, Mathias Kardell, Fatima Meza-Urzua, Letizia Bossini, Fethi Nacef, Franck Bellivier, Erkki Isometsä, Gunnar Morken, Elias Angelopoulos, Marco Pinna, Thomas Bjella, Fabiano G. Nery, Sergio Strejilevich, Markus Donix, Bernhard T. Baune, Ole A. Andreassen, Leonardo Tondo, Rajkumar Ramesar, Claudia Becerra-Palars, Arne E. Vaaler, Yosra Zgueb, Uta Ouali, Seetal Dodd, Rikke Krogh, Ute Lewitzka, Maurício Kunz, S. R. Bharathram, Bruno Etain, Carla Torrent, Mythily Subramaniam, Robert H. Belmaker, Martin Alda, Mónica Martínez-Cengotitabengoa, Mark Zetin, Ben Hassine, AbdelHakim, University Hospital Carl Gustav Carus [Dresden, Germany], Technische Universität Dresden = Dresden University of Technology (TU Dresden), ChronoRecord Association Inc. [Fullerton, USA], Dalhousie University [Halifax], Soviet Psychoneurological Hospital [Urai, Russia], Norwegian Centre for Mental Disorders Research [Oslo] (NORMENT), University of Oslo (UiO)-Haukeland University Hospital, University of Bergen (UiB)-University of Bergen (UiB)-Oslo University Hospital [Oslo], University of Athens Medical School [Athens], Università degli Studi di Cagliari = University of Cagliari (UniCa), Faculty of Medicine [Hacettepe University], Hacettepe University = Hacettepe Üniversitesi, Faculty of Medicine [Cologne], University Hospital of Cologne [Cologne]-University of Cologne, National Institute of Mental Health and Neurosciences [Bangalore, Inde] (NIMHANS ), Adelaide Medical School [Australia], University of Adelaide, National Institute of Psychiatry Ramón de la Fuente Muñiz [Mexico City] (INPRF), Variabilité de réponse aux Psychotropes (VariaPsy - U1144), Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Ben-Gurion University of the Negev (BGU), Deakin University [Burwood], University of Melbourne, Butabika Hospital [Kampala, Uganda], Università degli Studi di Siena = University of Siena (UNISI), Mood Disorders Clinic, Dr. Jose Horwitz Psychiatric Institute, Castle Peak Hospital [Hong Kong], Centre for Innovation in Mental and Physical Health and Clinical Treatment [Geelong Victoria, Australia] (IMPACT), Aristotle University of Thessaloniki, Mayo Clinic [Rochester], University of the Basque Country/Euskal Herriko Unibertsitatea (UPV/EHU), Northwestern University Feinberg School of Medicine, Mood Disorders Center of Ottawa (MDCO), University of Ottawa [Ottawa], Kobe University, Tokyo Metropolitan Matsuzawa Hospital [Tokyo, Japan], Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Perception et Mémoire / Perception and Memory, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), National Institute for Health and Welfare [Helsinki], Helsingin yliopisto = Helsingfors universitet = University of Helsinki, University of Tartu, Universidade Federal do Rio Grande do Sul [Porto Alegre] (UFRGS), Institute of Neuroscience and Physiology [Göteborg], Poznan University of Medical Sciences [Poland] (PUMS), BIPOLAR Zentrum Wiener Neustadt [Wiener Neustadt, Austria], Khanty-Mansiysk Clinical Psychoneurological Hospital [Khanty-Mansiysk, Russia], Aarhus University Hospital, Universidade de São Paulo Medical School (FMUSP), Karolinska Institutet [Stockholm], Aalborg University [Denmark] (AAU), Universidad de Antoquia, University of Calgary, University of Massachusetts Medical School [Worcester] (UMASS), University of Massachusetts System (UMASS), Institute of Mental Health [Singapore], Michigan State University [Traverse City], Michigan State University System, Department of Psychiatry [St. Olav's hospital, Trondheim], St. Olav's Hospital, Norwegian University of Science and Technology [Trondheim] (NTNU), Norwegian University of Science and Technology (NTNU), University of California [San Diego] (UC San Diego), University of California (UC), Asha Bipolar Clinic [Hyderabad, Telangana, India] (ABC), Université de Tunis El Manar (UTM), Faculté de Médecine de Tunis, Hospital Ángeles del Pedregal [Mexico City, Mexico], Centro Lucio Bini [Cagliari, Italy], Universidad Diego Portales [Santiago] (UDP), Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Stanford University School of Medicine [CA, USA], Goethe-Universität Frankfurt am Main, University of Missouri [Kansas City] (UMKC), University of Missouri System, Universidade Federal da Bahia (UFBA), Institute of Neuroscience Foundation Favaloro, Favaloro Foundation, Faculty of Medicine, University of Malaya [Kuala Lumpur, Malaisie], University of Malaya = Universiti Malaya [Kuala Lumpur, Malaisie] (UM), Tokyo Metropolitan Institute of Medical Science (TMIMS), McLean Hospital [Belmont, Ma.], University of Barcelona, Goethe-University Frankfurt am Main, Universitätsklinikum Frankfurt, Consejo Nacional de Ciencia y Tecnología [Mexico] (CONACYT), Chapman University, Semel Institute for Neuroscience and Human Behavior [Los Angeles, Ca], University of California [Los Angeles] (UCLA), University of California (UC)-University of California (UC), Michael Berk is supported by an NHMRC Senior Principal Research Fellowship (1059660). Ole A Andreassen, Thomas DBjella and Ingrid Melle are supported by Research Council of Norway (223273) and KG Jebsen Stiftelsen. Ravi Nadella has received funding from the Accelerator program for Discovery in Brain disorders using Stem cells (ADBS), jointly funded by the Department of Biotechnology, Government of India, and the Pratiksha trust. Biju Viswanath has received funding by Department of Science and Technology INSPIRE scheme, Government of India. Mikael Landén was supported by grants from the Swedish Research Council (K2014‐62X‐14647‐12‐51 and K2010‐61P‐21568‐01‐4), the Swedish foundation for Strategic Research (KF10‐0039), and the Swedish Federal Government under the LUA/ALF agreement (ALF 20130032, ALFGBG‐142041)., We thank Haydeh Olofsson for valuable data management support., Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Tokyo Metropolitan Institute of Medical Science, Universita degli Studi di Cagliari [Cagliari], University of the Basque Country [Bizkaia] (UPV/EHU), University of Helsinki, University of California, University of Malaya [Kuala Lumpur, Malaisie], University of California-University of California, University of Cologne-University Hospital of Cologne [Cologne], and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-IFR10
Subjects: Male, Internationality, Bipolar I disorder, Epidemiology, [SDV]Life Sciences [q-bio], 0302 clinical medicine, MESH: Asia/epidemiology, Age of Onset, Family history, First episode, MESH: Middle Aged, Circadian rhythm, Electromagnetic Radiation, MESH: Australia/epidemiology, Middle Aged, MESH: Seasons, 3. Good health, Europe, [SDV] Life Sciences [q-bio], MESH: Young Adult, Psychiatry and Mental Health, Solar insolation, Sunlight, Female, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Seasons, Solar System, medicine.symptom, Mania, Adult, MESH: Sunlight, Asia, Adolescent, Bipolar disorder, MESH: Electromagnetic Radiation, MESH: Age of Onset, MESH: Solar System, MESH: Internationality, Young Adult, 03 medical and health sciences, MESH: Bipolar Disorder/epidemiology, MESH: South America/epidemiology, medicine, Journal Article, Humans, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], MESH: Adolescent, MESH: Humans, business.industry, Australia, MESH: North America/epidemiology, MESH: Adult, South America, medicine.disease, MESH: Africa/epidemiology, MESH: Male, 030227 psychiatry, MESH: Europe/epidemiology, Mood disorders, 13. Climate action, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Africa, North America, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Age of onset, business, MESH: Female, 030217 neurology & neurosurgery, Demography
Abstract: OBJECTIVE: To confirm prior findings that the larger the maximum monthly increase in solar insolation in springtime, the younger the age of onset of bipolar disorder.METHOD: Data were collected from 5536 patients at 50 sites in 32 countries on six continents. Onset occurred at 456 locations in 57 countries. Variables included solar insolation, birth-cohort, family history, polarity of first episode and country physician density.RESULTS: There was a significant, inverse association between the maximum monthly increase in solar insolation at the onset location, and the age of onset. This effect was reduced in those without a family history of mood disorders and with a first episode of mania rather than depression. The maximum monthly increase occurred in springtime. The youngest birth-cohort had the youngest age of onset. All prior relationships were confirmed using both the entire sample, and only the youngest birth-cohort (all estimated coefficients P < 0.001).CONCLUSION: A large increase in springtime solar insolation may impact the onset of bipolar disorder, especially with a family history of mood disorders. Recent societal changes that affect light exposure (LED lighting, mobile devices backlit with LEDs) may influence adaptability to a springtime circadian challenge.
Published: 2017
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19. On the nature of Mullins effect in swollen nitrile rubber

Author: Mei Sze Loo, Andri Andriyana, Jean-Benoit Le Cam, Grégory Chagnon, Erwan Verron, Amalina Muhammad Afifi, University of Malaya [Kuala Lumpur, Malaisie], Laboratoire de Recherche en Mécanique Appliquée de l'Université de Rennes (LRMAUR), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Ingénierie Biomédicale et Mécanique des Matériaux (TIMC-IMAG-BioMMat), Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF), Institut de Recherche en Génie Civil et Mécanique (GeM), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-École Centrale de Nantes (ECN)-Centre National de la Recherche Scientifique (CNRS), University of Malaya [Kuala Lumpur], University of Malaya, Laboratoire de Recherche en Mécanique Appliquée de l'Université de Rennes ( LRMAUR ), Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ), Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications [Grenoble] ( TIMC-IMAG ), Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut polytechnique de Grenoble - Grenoble Institute of Technology ( Grenoble INP ) -IMAG-Centre National de la Recherche Scientifique ( CNRS ) -Université Grenoble Alpes ( UGA ), Institut de Recherche en Génie Civil et Mécanique ( GeM ), Université de Nantes ( UN ) -École Centrale de Nantes ( ECN ) -Centre National de la Recherche Scientifique ( CNRS ), Faculty of Engineering, University of Malaya, University of Malaya = Universiti Malaya [Kuala Lumpur, Malaisie] (UM), Université de Rennes (UR), and Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)
Subjects: [PHYS.MECA.MEMA]Physics [physics]/Mechanics [physics]/Mechanics of materials [physics.class-ph], [ PHYS.MECA.MEMA ] Physics [physics]/Mechanics [physics]/Mechanics of materials [physics.class-ph]
Abstract: International audience; Nitrile rubber is well recognized for its strength and oil resistance characteristic. The resistance to swelling inhydrocarbon oils permits it to be widely utilized in the industrial and automotive field, such as seals, gaskets, rollers andpackers. However, petroleum-based fuels are no longer dependable source of energy in terms of long term availability,increasing cost and environmental preservation. These undeniable issues have made biofuel a more attractive alternativeenergy source since it is known to have better sustainability and economic feasibility if compared to other choices ofrenewable energy sources. Despite the many advantages of biofuel, the material compatibility, in particularlyrubbers, in biofuel systems remains as a challenge till today.
Published: 2014

20. Enhanced performance of dye-sensitized solar cells based on organic dopant incorporated PVDF-HFP/PEO polymer blend electrolyte with g-C{sub 3}N{sub 4}/TiO{sub 2} photoanode

Author: Arof, A. [Centre for Ionics University Malaya, Department of Physics, University of Malaya, Kuala Lumpur 50603 (Malaysia)]
Published: 2016
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21. Novel bipyridinyl oxadiazole-based metal coordination complexes: High efficient and green synthesis of 3,4-dihydropyrimidin-2(1H)-ones through the Biginelli reactions

Author: Ng, Seik [Department of Chemistry, University of Malaya, Kuala Lumpur 50603 (Malaysia)]
Published: 2016
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22. Effect of viscous dissipation and radiation in an annular cone

Author: Azeem, null [Dept. of Computer System & Technology, University of Malaya, Kuala Lumpur (Malaysia)]
Published: 2016
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23. Synthesis and characterization of (Ni{sub 1−x}Co{sub x})Se{sub 2} based ternary selenides as electrocatalyst for triiodide reduction in dye-sensitized solar cells

Author: Arof, A. [Centre for Ionics University of Malaya, Department of Physics, University of Malaya, Kuala Lumpur 50603 (Malaysia)]
Published: 2016
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24. Heat transfer in porous medium embedded with vertical plate: Non-equilibrium approach - Part B

Author: Badruddin, Irfan [Dept. of Mechanical Engineering, University of Malaya, Kuala Lumpur, 50603 (Malaysia)]
Published: 2016
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25. Influence of radiation on double conjugate diffusion in a porous cavity

Author: Nik-Ghazali, N. [Dept. of Mechanical Engineering, University of Malaya, Kuala Lumpur, 50603 (Malaysia)]
Published: 2016
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26. Radiation dose to Malaysian infants from natural radionuclides via consumption of powdered milk

Author: Amin, Yusoff [Department of Physics, University of Malaya, Kuala Lumpur 50603 (Malaysia)]
Published: 2015
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27. Consensus statement on the role of health systems in advancing the long-term well-being of people living with HIV

Author: Graham S Cooke, Adeeba Kamarulzaman, Margaret Hellard, Jürgen K. Rockstroh, Kenneth H. Mayer, Georg M. N. Behrens, Denise Naniche, Nikos Dedes, Ricardo Baptista Leite, Jeffrey V. Lazarus, David Serwadda, Sanjay Bhagani, María José Fuster-Ruiz de Apodaca, Laura Waters, Shabbar Jaffar, Carlos F. Caceres, Diana Romero, Peter Reiss, Richard Elliott, Susan Buchbinder, Pedro Cahn, Richard Harding, Julia del Amo, Reena Rajasuriar, Teymur Noori, Kelly Safreed-Harmon, Antonella d'Arminio Monforte, Timothy B. Hallett, Jane Anderson, Wafaa El-Sadr, Darren L. Brown, Marina B. Klein, Doreen Moraa, Sharon R Lewin, Nesrine Rizk, Denis Nash, Giovanni Guaraldi, Graham Brown, Anton Pozniak, Georgina Caswell, Caroline A. Sabin, Linda-Gail Bekker, Patrizia Carrieri, Meaghan Kall, José Antonio Pérez-Molina, Instituto de Salud Global - Institute For Global Health [Barcelona] (ISGlobal), University of Malaya [Kuala Lumpur, Malaisie], Homerton University Hospital, Portuguese National Parliament [Lisbon, Portugal] (PNP), Medizinische Hochschule Hannover (MHH), The Desmond Tutu HIV Centre [Cape Town, South Africa], University College of London [London] (UCL), Chelsea and Westminster NHS Foundation Trust [London, UK], University of New South Wales [Sydney] (UNSW), San Francisco Department of Public Health [San Francisco, CA, USA] (SFDPH), Universidad Peruana Cayetano Heredia (UPCH), Fundación Huésped [Buenos Aires], Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut des sciences de la santé publique [Marseille] (ISSPAM), Global Network of People Living with HIV (GNP+) [Cape Town, South Africa], Imperial College London, University of Milan, Positive Voice [Athens, Greece] (PV), Ministerio de Sanidad/Ministry of Health [Madrid, Spain], HIV Legal Network [Toronto, ON, Canada], Columbia University [New York], Universidad Nacional de Educación a Distancia (UNED), Università degli Studi di Modena e Reggio Emilia (UNIMORE), King‘s College London, Burnet Institute [Melbourne, Victoria], Liverpool School of Tropical Medicine (LSTM), Public Health England [London], McGill University Health Center [Montreal] (MUHC), The Peter Doherty Institute for Infection and Immunity [Melbourne], University of Melbourne-The Royal Melbourne Hospital, Monash University [Melbourne], Harvard Medical School [Boston] (HMS), Hospital Universitario Ramón y Cajal [Madrid], Universidad de Alcalá - University of Alcalá (UAH), ESA YOUTH 2030 [Nairobi, Kenya], City University of New York [New York] (CUNY), European Centre for Disease Prevention and Control (ECDC), London School of Hygiene and Tropical Medicine (LSHTM), University of Amsterdam [Amsterdam] (UvA), American University of Beirut [Beyrouth] (AUB), University Hospital Bonn, Makerere University [Kampala, Ouganda] (MAK), Central and North West London NHS Foundation Trust [London, UK], University of Malaya = Universiti Malaya [Kuala Lumpur, Malaisie] (UM), Università degli Studi di Milano = University of Milan (UNIMI), Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE), Malbec, Odile, Ministerio de Sanidad / Ministry of Health [Madrid, Spain], European Centre for Disease Prevention and Control [Stockholm, Sweden] (ECDC), and Medical Research Council (MRC)
Subjects: Gerontology, SYMPTOMS, Social stigma, STIGMA REDUCTION, IMPACT, [SDV]Life Sciences [q-bio], Social Stigma, General Physics and Astronomy, wc_503, HIV Infections, Disease, Comorbidity, DISEASE, Comorbidities, socioeconomic conditions, 0302 clinical medicine, ANTIRETROVIRAL THERAPY, QUALITY-OF-LIFE, Surveys and Questionnaires, Health care, Medicine, 030212 general & internal medicine, RISK, Multidisciplinary, human immunodeficiency virus, 030503 health policy & services, Health services, 3. Good health, Multidisciplinary Sciences, [SDV] Life Sciences [q-bio], HUMAN-IMMUNODEFICIENCY-VIRUS, Perspective, Science & Technology - Other Topics, 0305 other medical science, Adult, Quality of life, wc_503_2, Consensus, Science, Stigma (botany), VALIDATION, General Biochemistry, Genetics and Molecular Biology, long-term change, 03 medical and health sciences, Quality of life (healthcare), Acquired immunodeficiency syndrome (AIDS), Humans, Science & Technology, business.industry, General Chemistry, CARE, medicine.disease, Mental health, quality of life, Well-being, Morbidity, business, Delivery of Health Care
Abstract: Health systems have improved their abilities to identify, diagnose, treat and, increasingly, achieve viral suppression among people living with HIV (PLHIV). Despite these advances, a higher burden of multimorbidity and poorer health-related quality of life are reported by many PLHIV in comparison to people without HIV. Stigma and discrimination further exacerbate these poor outcomes. A global multidisciplinary group of HIV experts developed a consensus statement identifying key issues that health systems must address in order to move beyond the HIV field’s longtime emphasis on viral suppression to instead deliver integrated, person-centered healthcare for PLHIV throughout their lives.
Published: 2021
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28. Insight in the quorum sensing-driven lifestyle of the non-pathogenic Agrobacterium tumefaciens 6N2 and the interactions with the yeast Meyerozyma guilliermondii

Author: Yves Dessaux, Carlos G. Nieto-Peñalver, Camille Garcia, Thibaut Léger, Lucía I. C. de Figueroa, Teik Min Chong, Kok-Gan Chan, Jean-Michel Camadro, Elisa Violeta Bertini, Mariela Analía Torres, Kar-Wai Hong, Planta Piloto de Procesos Industriales Microbiológicos [Tucumán] (PROIMI), Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] (CONICET), Laboratoire de Fougères - ANSES, Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Institut Jacques Monod (IJM (UMR_7592)), Université de Paris (UP)-Centre National de la Recherche Scientifique (CNRS), JiangSu University, University of Malaya [Kuala Lumpur, Malaisie], Shantou University [Shantou, China], UCSI University, Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), This work was supported by the Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET, PIP 2015 N°0946, PU-E22920160100012CO), Agencia Nacional de Promoción Científica y Tecnológica (PICT 2016 N° 0532, PICT 2016 N° 2013), and Secretaría de Ciencia, Arte e Innovación Tecnológica from the Universidad Nacional de Tucumán (PIUNT D609). Kok-Gan Chan thanks the financial support from the University of Malaya (FRGS grant no. FP022-2018A). Carlos Nieto-Peñalver thanks the support from Université Paris Diderot through the Alicia Moreau Chair., Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), and University of Malaya = Universiti Malaya [Kuala Lumpur, Malaisie] (UM)
Subjects: Proteomics, Microorganism, [SDV]Life Sciences [q-bio], détection de quorum, Biology, yeast, MESH: Quorum Sensing, 03 medical and health sciences, Bacterial Proteins, Meyerozyma guilliermondii, agrobactérie, Genetics, agrobacteria, microbiologie, Receptor, MESH: Saccharomycetales, bacteria, MESH: Bacterial Proteins, endophytic, levure, proteomic, 030304 developmental biology, bactérie, 0303 health sciences, Strain (chemistry), 030306 microbiology, intéractions, MESH: Proteomics, MESH: Agrobacterium tumefaciens, microbiology, food and beverages, quorum sensing, Agrobacterium tumefaciens, interactions, biology.organism_classification, Yeast, Quorum sensing, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Saccharomycetales, endophyte
Abstract: International audience; Agrobacterium tumefaciens is considered a prominent phytopathogen, though most isolates are nonpathogenic. Agrobacteria can inhabit plant tissues interacting with other microorganisms. Yeasts are likewise part of these communities. We analyzed the quorum sensing (QS) systems of A. tumefaciens strain 6N2, and its relevance for the interaction with the yeast Meyerozyma guilliermondii, both sugarcane endophytes. We show that strain 6N2 is nonpathogenic, produces OHC8-HSL, OHC10-HSL, OC12-HSL and OHC12-HSL as QS signals, and possesses a complex QS architecture, with one truncated, two complete systems, and three additional QS-signal receptors. A proteomic approach showed differences in QS-regulated proteins between pure (64 proteins) and dual (33 proteins) cultures. Seven proteins were consistently regulated by quorum sensing in pure and dual cultures. M. guilliermondii proteins influenced by QS activity were also evaluated. Several up- and down- regulated proteins differed depending on the bacterial QS. These results show the QS regulation in the bacteria-yeast interactions.; [Figure: see text].
Published: 2021
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29. A set of alkali and alkaline-earth coordination polymers based on the ligand 2-(1H-benzotriazol-1-yl) acetic acid: Effects the radius of metal ions on structures and properties

Author: Weng Ng, Seik [Department of Chemistry, University of Malaya, Kuala Lumpur 50603 (Malaysia)]
Published: 2014
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30. Comparative global epidemiology of influenza, respiratory syncytial and parainfluenza viruses, 2010–2015

Author: Matti Waris, Aripuana Watanabe, Darmaa Badarch, Inspire, H. Lee, Hamid Jalal, Jen Kok, Alice Kabanda, Yang Liu, Pieter L. A. Fraaij, Steven J. Drews, Tommy Tsan-Yuk Lam, André Corriveau, Marion Koopmans, Theo P. Sloots, Sarah Tozer, Ghassan Dbaibo, Jean-Michel Heraud, Florence Lai, Julian W. Tang, Hassan Zaraket, Kok Keng Tee, Mel Krajden, Lance C. Jennings, Pagbajabyn Nymadawa, Hidekazu Nishimura, Dominic E. Dwyer, Seweryn Bialasiewicz, Evelyn Sc Koay, Todd F Hachette, Paul K.S. Chan, Pediatrics, Virology, The University of Hong Kong (HKU), Leicester Royal Infirmary, University Hospitals Leicester, University of Leicester, American University of Beirut [Beyrouth] (AUB), University of Queensland [Brisbane], Children’s Health Queensland [Brisbane] (CHQ), Unité de Virologie [Antananarivo, Madagascar] (IPM), Institut Pasteur de Madagascar, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), University of Alberta, Dalhousie University [Halifax], The Chinese University of Hong Kong [Hong Kong], National University of Singapore (NUS), National University Hospital [Singapore] (NUH), University of Malaya [Kuala Lumpur, Malaisie], Erasmus University Medical Center [Rotterdam] (Erasmus MC), University of Otago [Dunedin, Nouvelle-Zélande], University of Turku, Turku University Hospital (TYKS), British Colombia Centre for Disease Control [Vancouver] (BCCDC), Government of the Northwest Territories [Yellowknife, Canada], Addenbrooke's Hospital, Cambridge University NHS Trust, Sendai Medical Center, National Center for Communicable Disease [Mongolia] (NCCD), Universidade Federal de Juiz de Fora (UFJF), National Reference Laboratory [Kigali, Rwanda], Westmead Hospital [Sydney], The University of Sydney, and ST was supported by the Children's Hospital Foundation Sakzewski Translational Research grant (no. 10416). TL was supported by Theme-based Research Scheme (T11-705/14-N) from University Grants Committee of the HKSAR.
Subjects: 0301 basic medicine, Epidemiology, viruses, MESH: Asia, Southeastern, MESH: Respiratory Syncytial Virus, Human, MESH: Molecular Diagnostic Techniques, Social responsibility, MESH: Africa, Respiratory syncytial virus, Parainfluenza virus, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, 030212 general & internal medicine, Respiratory system, MESH: Influenza B virus, Asia, Southeastern, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, Paramyxoviridae Infections, Incidence (epidemiology), MESH: Influenza, Human, Incidence, Global, 3. Good health, Europe, Infectious Diseases, Molecular Diagnostic Techniques, Influenza A virus, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Seasons, Microbiology (medical), medicine.medical_specialty, Social distancing, 030106 microbiology, MESH: Influenza A virus, Respiratory Syncytial Virus Infections, Biology, Virus, Respirovirus, Article, 03 medical and health sciences, MESH: Respiratory Syncytial Virus Infections, Middle East, Influenza activity, Face mask, Incidence data, Influenza, Human, medicine, Humans, Kuala lumpur, MESH: Australasia, MESH: Humans, Australasia, Tropics, COVID-19, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, Seasonality, Virology, MESH: North America, Out of phase, Influenza B virus, MESH: Respirovirus, MESH: Middle East, Respiratory Syncytial Virus, Human, Multiple sampling, MESH: Paramyxoviridae Infections, Africa, North America, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Europe, Influenza virus, MESH: Seasons
Abstract: International audience; ObjectivesTo improve our understanding of the global epidemiology of common respiratory viruses by analysing their contemporaneous incidence at multiple sites.Methods2010–2015 incidence data for influenza A (IAV), influenza B (IBV), respiratory syncytial (RSV) and parainfluenza (PIV) virus infections were collected from 18 sites (14 countries), consisting of local (n = 6), regional (n = 9) and national (n = 3) laboratories using molecular diagnostic methods. Each site submitted monthly virus incidence data, together with details of their patient populations tested and diagnostic assays used.ResultsFor the Northern Hemisphere temperate countries, the IAV, IBV and RSV incidence peaks were 2–6 months out of phase with those in the Southern Hemisphere, with IAV having a sharp out-of-phase difference at 6 months, whereas IBV and RSV showed more variable out-of-phase differences of 2–6 months. The tropical sites Singapore and Kuala Lumpur showed fluctuating incidence of these viruses throughout the year, whereas subtropical sites such as Hong Kong, Brisbane and Sydney showed distinctive biannual peaks for IAV but not for RSV and PIV.ConclusionsThere was a notable pattern of synchrony of IAV, IBV and RSV incidence peaks globally, and within countries with multiple sampling sites (Canada, UK, Australia), despite significant distances between these sites.
Published: 2019
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31. Synthesis of Cs-ABW nanozeolite in organotemplate-free system

Author: Svetlana Mintova, Séverinne Rigolet, Eng-Poh Ng, Tamara Mahmoud Ali Ghrear, T. Jean Daou, Soon Huat Tan, Tau Chuan Ling, Universiti Sains Malaysia (USM), Laboratoire de Matériaux à Porosité Contrôlée (LMPC), Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Ecole Nationale Supérieure de Chimie de Mulhouse-Centre National de la Recherche Scientifique (CNRS), Institut de Science des Matériaux de Mulhouse (IS2M), Centre National de la Recherche Scientifique (CNRS)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Laboratoire catalyse et spectrochimie (LCS), Centre National de la Recherche Scientifique (CNRS)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Normandie Université (NU)-Institut de Chimie du CNRS (INC)-Université de Caen Normandie (UNICAEN), Normandie Université (NU), University of Malaya [Kuala Lumpur, Malaisie], Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS), Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), University of Malaya = Universiti Malaya [Kuala Lumpur, Malaisie] (UM), and Roland, Pascal
Subjects: Materials science, Nucleation, Crystal growth, 02 engineering and technology, Template-free synthesis, 010402 general chemistry, 01 natural sciences, Hydrothermal circulation, law.invention, law, [CHIM] Chemical Sciences, [CHIM]Chemical Sciences, General Materials Science, Crystallization, Zeolite, General Chemistry, Fast hydrothermal synthesis, 021001 nanoscience & nanotechnology, Condensed Matter Physics, 0104 chemical sciences, Nanocrystal, Chemical engineering, Mechanics of Materials, Agglomerate, Zeolite nanocrystals, Yield (chemistry), Cs-ABW, 0210 nano-technology
Abstract: International audience; Cesium-aluminosilicate zeolite nanocrystals with ABW framework structure are synthesized free of organic template using hydrothermal approach. The crystallization process of Cs-ABW zeolite nanocrystals by varying the initial gel molar composition, heating temperature and crystallization time was studied. More detailed investigations of the formation of Cs-ABW nanozeolite using a reactive clear precursor hydrogel (4SiO2:1Al2O3:16Cs2O:160H2O) were then carried out. Fully crystalline Cs-ABW nanozeolites were obtained within 120 min at 180 °C and 22 bar, which is considerably faster and safer in comparison to the currently available method involving treatment at 695 °C, 1000 bar and 46 h. The Cs-ABW nanocrystals have grain shape morphology with a mean size of 32 nm and they do not agglomerate for long durations. The nanosized Cs-ABW zeolite has high alumina content (Si/Al ratio = 1.04). These nanocrystals can be prepared in high solid yield (ca. 82%) thus offering a promising route for large-scale production of highly basic zeolite nanoparticles.
Published: 2019
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32. Doubly-excited {sup 1,3}D{sup e} resonance states of two-electron positive ions Li{sup +} and Be{sup 2+} in Debye plasmas

Author: Ratnavelu, K. [Institute of Mathematical Sciences, University of Malaya, Kuala Lumpur (Malaysia)]
Published: 2014
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33. Properties of Ta{sub 2}O{sub 5} thin films prepared by ion-assisted deposition

Author: Bushroa, A. [Center of Advanced Manufacturing and Material Processing, Department of Engineering Design and Manufacture, Faculty of Engineering, University of Malaya, Kuala Lumpur 50603 (Malaysia)]
Published: 2013
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34. Offretite zeolite single crystals crystallized using amphiphile-templating approach

Author: Ng, Eng-Poh, Ahmad, Nur Hidayahni, Khoerunnisa, Fitri, Mintova, Svetlana, Ling, Tau Chuan, Daou, T. Jean, School of Chemical Sciences, Universiti Sains Malaysia, Universiti Sains Malaysia (USM), University of Hail, Universitas Pendidikan Indonesia, Partenaires INRAE, Laboratoire catalyse et spectrochimie (LCS), Centre National de la Recherche Scientifique (CNRS)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Normandie Université (NU)-Institut de Chimie du CNRS (INC)-Université de Caen Normandie (UNICAEN), Normandie Université (NU), University of Malaya [Kuala Lumpur, Malaisie], Institut de Science des Matériaux de Mulhouse (IS2M), Centre National de la Recherche Scientifique (CNRS)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, and Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)
Subjects: Amphiphile-templating approach, Offretite zeolite, [CHIM]Chemical Sciences, Crystal growth, Hierarchical zeolites, Acylation of 2-methylfuran
Abstract: International audience; Offretite zeolite synthesis in the presence of cetyltrimethylammonium bromide (CTABr) is reported for the first time. The offretite crystals exhibited novel hexagonal prismatic shape with high crystallinity after only 72 h of hydrothermal treatment at 180 o C which is considerably faster than the already known synthesis procedure used for the preparation of offretite. The study showed that CTABr has dual-functions during crystallization of offretite, viz. as structure-directing agent and as mesoporogen. The resulting offretite crystals (Si/Al ratio = 4.1) possess more acid sites than the conventional offretite thanks to its high 2 crystallinity and hierarchical structure. The synthesized zeolite is also more reactive than its conventional counterpart in the acylation of 2-methylfuran for biofuel production under nonmicrowave instant heating condition, giving 83.5% conversion with 100% selectivity to the desired product 2-acetyl-5-methylfuran. Hence, this amphiphile synthesis approach offers another cost-effective and alternative route for crystallizing zeolite materials that require expensive organic templates.
Published: 2021
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35. A review of the genus Changiola (Orthoptera: Grylloidea: Pteroplistinae) and description of the first species from Borneo

Author: Tony Robillard, Amira Aqilah Muhammad, Ming Kai Tan, Institut de Systématique, Evolution, Biodiversité (ISYEB ), Muséum national d'Histoire naturelle (MNHN)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA), and University of Malaya [Kuala Lumpur, Malaisie]
Subjects: 0106 biological sciences, Subfamily, Insecta, Arthropoda, Orthoptera, gryllidae, 010607 zoology, Zoology, Sarawak, Biology, [SDV.BID.SPT]Life Sciences [q-bio]/Biodiversity/Systematics, Phylogenetics and taxonomy, 010603 evolutionary biology, 01 natural sciences, Malay peninsula, Borneo, Genus, Cricket, Animals, Body Size, Animalia, Southeast asia, Ecology, Evolution, Behavior and Systematics, Taxonomy, Haglotettigoniidae, key to species, Animal Structures, Biodiversity, biology.organism_classification, [SDV.BA.ZI]Life Sciences [q-bio]/Animal biology/Invertebrate Zoology, Key (lock), Animal Science and Zoology, Taxonomy (biology), Grylloidea, Animal Distribution
Abstract: International audience; The taxonomy of the little-known cricket genus Changiola from the subfamily Pteroplistinae is reviewed here. This genus consisted of three species, two from Malay Peninsula and one from Indochina. here, we describe a new species from borneo, the first from the island: Changiola sarawakensis n. sp. We also provide a key to the species, although it is likely that more species will be added to this genus with more sampling in the region.
Published: 2021
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36. Effects of Synthesis Parameters on the Crystallization and Morphological Profiles of SAPO-5 Templated by 1-Benzyl-2,3dimethyl-1H-imidazol-3-ium Hydroxide

Author: Auwal, Ismail Alhassan, Dubray, Florent, Wong, Ka-Lun, Khoerunnisa, Fitri, Ling, Tau Chuan, Mintova, Svetlana, Ng, Eng-Poh, Universiti Sains Malaysia (USM), Laboratoire catalyse et spectrochimie (LCS), Centre National de la Recherche Scientifique (CNRS)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Normandie Université (NU)-Institut de Chimie du CNRS (INC)-Université de Caen Normandie (UNICAEN), Normandie Université (NU), Nanyang Technological University [Singapour], Universitas Pendidikan Indonesia, Partenaires INRAE, University of Malaya [Kuala Lumpur, Malaisie], and School of Chemical Sciences, Universiti Sains Malaysia
Subjects: Zeolite, 3-dimethyl-1H-imidazol-3ium hydroxide, 1-Benzyl-2, [CHIM]Chemical Sciences, Hydrothermal condition, Crystallization process, SAPO-5
Abstract: International audience; The formation of SAPO-5 molecular sieves is investigated under hydrothermal conditions and templated by a new structure-directing agent, 1-benzyl-2,3-dimethyl-1H-imidazol-3-ium hydroxide ([Bzm]OH). The synthesis was carried out by tuning the synthesis parameters, viz. crystallization temperature, heating time and reactants molar composition (SiO 2 , Al 2 O 3 , P 2 O 5 , [Bzm] + , H 2 O) so as to study the roles of each synthesis parameter towards the formation of SAPO-5. The results showed that these synthesis parameters had significant influences on the entire crystallization process (induction, nucleation, crystal growth, and Ostwald ripening) and physicochemical properties of SAPO-5 (morphology and crystal size). Moreover, this study also demonstrated a fast hydrothermal synthesis approach where SAPO-5 molecular sieve with hexagonal prism morphology could be crystallized within 10 h instead of days using novel [Bzm]OH heterocyclic template thus offering an alternative route for synthesizing zeolite-like materials for advanced applications.
Published: 2021
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37. Functional spatial principal Component Analysis and Application to demography

Author: Pathmanathan, Dharini, Hassan, Alaa Ali, Hassan, Alaa, Dabo-Niang, Sophie, MOdel for Data Analysis and Learning (MODAL), Inria Lille - Nord Europe, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire Paul Painlevé - UMR 8524 (LPP), Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Evaluation des technologies de santé et des pratiques médicales - ULR 2694 (METRICS), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-École polytechnique universitaire de Lille (Polytech Lille)-Université de Lille, Sciences et Technologies, University of Malaya [Kuala Lumpur, Malaisie], Laboratoire Paul Painlevé - UMR 8524 (LPP), Université de Lille-Centre National de la Recherche Scientifique (CNRS), University of Malaya = Universiti Malaya [Kuala Lumpur, Malaisie] (UM), Laboratoire Paul Painlevé (LPP), Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université de Lille, Sciences et Technologies-Inria Lille - Nord Europe, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Evaluation des technologies de santé et des pratiques médicales - ULR 2694 (METRICS), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-École polytechnique universitaire de Lille (Polytech Lille), and Dabo-Niang, Sophie
Subjects: Moran's I, functional principal component analysis, contiguity, [MATH.MATH-ST]Mathematics [math]/Statistics [math.ST], KNN, [MATH.MATH-ST] Mathematics [math]/Statistics [math.ST], spatial autocorrelation, mortality
Abstract: We examined the spatial autocorrelation of mortality rates for 28 European countries, with data from the Human Mortality Database (HMD) using spatial associations in the context of functional areal data. We developed a functional Moran's I statistic which is the first of its kind in the functional data analysis framework to determine spatial autocorrelation and spatial PCA for areal data. These data were converted to functions before performing the classical and spatial PCA. Results showed the existence of spatial autocorrelation between neighbouring countries (using K-nearest neighbours (KNN) and contiguity neighbours) based on the functional Moran's I statistic applied on the functional PCA approximation. However, no strong correlation was displayed when the scores of the classical PCA which ignored spatial information, was considered. This work proved the existence of spatial dependency in mortality rates of neighbouring countries in Europe and showed that the functional Moran's I statistic is a powerful tool in measuring spatial dependency.
Published: 2021

38. Growth and characterization of Cl-doped ZnO hexagonal nanodisks

Author: Mahmoudian, M [Department of Chemistry, University of Malaya, Kuala Lumpur 50603 (Malaysia)]
Published: 2011
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39. Stochastic dynamics of charge fluctuations in dusty plasma: A non-Markovian approach

Author: Wong, C [Plasma Research Laboratory, Department of Physics, University of Malaya, Kuala Lumpur 50603 (Malaysia)]
Published: 2011
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40. Role of Triple Phonon Excitations on Large Angle Quasi-elastic Scattering of {sup 54}Cr+{sup 208}Pb System

Author: Kasim, Hasan [Department of Physics, University of Malaya, Kuala Lumpur 50603 (Malaysia)]
Published: 2011
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41. Dielectric Properties of PVDF/PZT

Author: Majid, W [Low dimensional material research center, Department of physics, Faculty of Science, University of Malaya, Kuala Lumpur 50603 (Malaysia)]
Published: 2011
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42. Synthesis and Characterization of Lead Calcium Titanate Nanocomposite

Author: Muhamad, M [Low dimensional materials research centre, Department of Physics, University of Malaya, Kuala Lumpur 50603 (Malaysia)]
Published: 2011
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43. Six Impossible Things: Fractional Charge From Laughlin's Wave Function

Author: Shrivastava, Keshav [Department of Physics, Faculty of Science, University of Malaya, Kuala Lumpur 50603 (Malaysia)]
Published: 2010
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44. Probing the Structure of {sup 74}Ge Nucleus with Coupled-channels Analysis of {sup 74}Ge+{sup 74}Ge Fusion Reaction

Author: Kasim, Hasan [Deparment of Physics University of Malaya, Kuala Lumpur, 50603 (Malaysia)]
Published: 2010
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45. Clustering DNA sequences for phylogenetic trees using a functional data framework

Author: Dabo-Niang, Sophie, Pathmanathan, Dharini, Omar, Hasmahzaiti, Dabo-Niang, Sophie, MOdel for Data Analysis and Learning (MODAL), Inria Lille - Nord Europe, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire Paul Painlevé - UMR 8524 (LPP), Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Evaluation des technologies de santé et des pratiques médicales - ULR 2694 (METRICS), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-École polytechnique universitaire de Lille (Polytech Lille)-Université de Lille, Sciences et Technologies, University of Malaya [Kuala Lumpur, Malaisie], Laboratoire Paul Painlevé (LPP), Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université de Lille, Sciences et Technologies-Inria Lille - Nord Europe, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Evaluation des technologies de santé et des pratiques médicales - ULR 2694 (METRICS), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-École polytechnique universitaire de Lille (Polytech Lille), and University of Malaya = Universiti Malaya [Kuala Lumpur, Malaisie] (UM)
Subjects: [MATH.MATH-ST]Mathematics [math]/Statistics [math.ST], [MATH.MATH-ST] Mathematics [math]/Statistics [math.ST]
Published: 2021

46. Quality and readability of web-based Arabic health information on COVID-19: an infodemiological study

Author: Halboub, Esam, Al-Ak’hali, Mohammed Sultan, Al-Mekhlafi, Hesham, Alhajj, Mohammed Nasser, Jazan University, Sana'a University, University of Malaya [Kuala Lumpur, Malaisie], and Thamar University
Subjects: Public health, Health information, [SHS.INFO]Humanities and Social Sciences/Library and information sciences, Misinformation, COVID-19, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Infodemiology, Quality
Abstract: International audience; Background: This study sought to assess the quality and readability of web-based Arabic health information on COVID-19.Methods: Three search engines were searched on 13 April 2020 for specific Arabic terms on COVID-19. The first 100 consecutive websites from each engine were analyzed for eligibility, which resulted in a sample of 36 websites. These websites were subjected to quality assessments using the Journal of the American Medical Association (JAMA) benchmarks tool, the DISCERN tool, and Health on the Net Foundation Code of Conduct (HONcode) certification. The readability of the websites was assessed using an online readability calculator.Results: Among the 36 eligible websites, only one (2.7%) was HONcode certified. No website attained a high score based on the criteria of the DISCERN tool; the mean score of all websites was 31.5 ± 12.55. As regards the JAMA benchmarks results, a mean score of 2.08 ± 1.05 was achieved by the websites; however, only four (11.1%) met all the JAMA criteria. The average grade levels for readability were 7.2 ± 7.5, 3.3 ± 0.6 and 93.5 ± 19.4 for the Flesch Kincaid Grade Level, Simple Measure of Gobbledygook, and Flesch Reading Ease scales, respectively.Conclusion: Almost all of the most easily accessible web-based Arabic health information on COVID-19 does not meet recognized quality standards regardless of the level of readability and ability to be understood by the general population of Arabic speakers.
Published: 2021
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47. Erratum: 'Effects of strength of dispersion and dust density on the formation of solitons and shocks in unmagnetized dusty plasma' [Phys. Plasmas 16, 073702 (2009)]

Author: Wong, C [Plasma Research Laboratory, Department of Physics, University of Malaya, Kuala Lumpur 50603 (Malaysia)]
Published: 2009
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48. The fractional quantum Hall effect: The cases of 5/2 and 12/5

Author: Shrivastava, Keshav [Department of Physics, University of Malaya, Kuala Lumpur 50603 (Malaysia)]
Published: 2009
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49. Pfaffian States: Quantum Computation

Author: Shrivastava, Keshav [Department of Physics, University of Malaya, Kuala Lumpur 50603 (Malaysia)]
Published: 2009
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50. Screening and eradication of Helicobacter pylori for gastric cancer prevention: the Taipei global consensus

Author: Deng-Chyang Wu, Francis K.L. Chan, Chieh Chang Chen, Wei Lun Chang, David Y. Graham, Jyh-Ming Liou, Khay Guan Yeoh, Bor Shyang Sheu, Tsung-Hsien Chiang, Alex Hwong Ruey Leow, Joseph J.Y. Sung, Varocha Mahachai, Khean-Lee Goh, Francis Mégraud, Ming-Shiang Wu, Yi-Chia Lee, Kentaro Sugano, Tzu Chan Hong, Emad M. El-Omar, Takuji Gotoda, Peter Malfertheiner, Ping-I. Hsu, Mei Jyh Chen, Yoshio Yamaoka, Chun Ying Wu, Hong Lu, Jaw-Town Lin, Jeng Yih Wu, Hsiu Chi Cheng, National Taiwan University Hospital [Taipei], National Taiwan University College of Medicine [Taipei], National Taiwan University Cancer Center [Taipei], Otto-von-Guericke University [Magdeburg] (OVGU), Ludwig Maximilian University [Munich] (LMU), National Cheng Kung University Hospital [Tainan], Kaohsiung Medical University Hospital, Jichi Medical School [Tochigi], Tainan Hospital [Tainan], National University of Singapore (NUS), China Medical University [Tainan], University of Malaya [Kuala Lumpur, Malaisie], Chulalongkorn University [Bangkok], King Chulalongkorn Memorial Hospital [Bangkok], Nihon University School of Medicine [Tokyo, Japan], National Yang Ming University (NYMU), Taipei Veterans General Hospital [Taiwan], National Taiwan University Hospital Bei-Hu Branch [Taipei], Shanghai Jiao Tong University [Shanghai], Oita University Faculty of Medicine [Oita, Japon], Michael E. DeBakey Veterans Affairs Medical Center [Houston] (MEDVAMC), Baylor College of Medicine (BCM), Baylor University, Physiopathologie du cancer du foie, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM), French National Reference Centre for Helicobacters, CHU de Bordeaux Pellegrin [Bordeaux], The Chinese University of Hong Kong [Hong Kong], China Medical University Hospital [Taichung], University of New South Wales [Sydney] (UNSW), Asian Pacific Alliance on Helicobacter and Microbiota (APAHAM), Megraud, Francis, Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg] (OVGU), Jichi Medical University [Tochigi-Ken, Japan], and University of Malaya = Universiti Malaya [Kuala Lumpur, Malaisie] (UM)
Subjects: medicine.medical_specialty, Atrophic gastritis, Asymptomatic, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Health care, medicine, Young adult, Mass screening, 030304 developmental biology, 0303 health sciences, Cancer prevention, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, biology, cancer prevention, business.industry, gastric cancer, screening, Gastroenterology, Intestinal metaplasia, helicobacter pylori - treatment, Helicobacter pylori, biology.organism_classification, medicine.disease, 3. Good health, helicobacter pylori, 030211 gastroenterology & hepatology, medicine.symptom, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: ObjectiveA global consensus meeting was held to review current evidence and knowledge gaps and propose collaborative studies on population-wide screening and eradication of Helicobacter pylori for prevention of gastric cancer (GC).Methods28 experts from 11 countries reviewed the evidence and modified the statements using the Delphi method, with consensus level predefined as ≥80% of agreement on each statement. The Grading of Recommendation Assessment, Development and Evaluation (GRADE) approach was followed.ResultsConsensus was reached in 26 statements. At an individual level, eradication of H. pylori reduces the risk of GC in asymptomatic subjects and is recommended unless there are competing considerations. In cohorts of vulnerable subjects (eg, first-degree relatives of patients with GC), a screen-and-treat strategy is also beneficial. H. pylori eradication in patients with early GC after curative endoscopic resection reduces the risk of metachronous cancer and calls for a re-examination on the hypothesis of ‘the point of no return’. At the general population level, the strategy of screen-and-treat for H. pylori infection is most cost-effective in young adults in regions with a high incidence of GC and is recommended preferably before the development of atrophic gastritis and intestinal metaplasia. However, such a strategy may still be effective in people aged over 50, and may be integrated or included into national healthcare priorities, such as colorectal cancer screening programmes, to optimise the resources. Reliable locally effective regimens based on the principles of antibiotic stewardship are recommended. Subjects at higher risk of GC, such as those with advanced gastric atrophy or intestinal metaplasia, should receive surveillance endoscopy after eradication of H. pylori.ConclusionEvidence supports the proposal that eradication therapy should be offered to all individuals infected with H. pylori. Vulnerable subjects should be tested, and treated if the test is positive. Mass screening and eradication of H. pylori should be considered in populations at higher risk of GC.
Published: 2020
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