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157 results on '"University of Kentucky (UK)"'

1. Some trace monotonicity properties and applications

Author: Jean-Michel Combes, Peter D. Hislop, CPT - E8 Dynamique quantique et analyse spectrale, Centre de Physique Théorique - UMR 7332 (CPT), Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), University of Kentucky, Department of Mathematics, University of Kentucky (UK)-University of Kentucky (UK), and University of Kentucky-University of Kentucky
Subjects: Pure mathematics, Control and Optimization, Trace (linear algebra), Relation (database), [PHYS.MPHY]Physics [physics]/Mathematical Physics [math-ph], Loewner’s Theorem, FOS: Physical sciences, Monotonic function, 47B80, 47A60, operator monotone functions, [MATH.MATH-FA]Mathematics [math]/Functional Analysis [math.FA], random Schrodinger operators, symbols.namesake, FOS: Mathematics, Mathematical Physics, Mathematics, Algebra and Number Theory, Continuum (topology), operator trace inequalities, Wegner estimate, Mathematical Physics (math-ph), Mathematics::Spectral Theory, Functional Analysis (math.FA), Mathematics - Functional Analysis, 47B10, 47B10, 81Q10, 47B80, symbols, Analysis, Schrödinger's cat
Abstract: We present some results on the monotonicity of some traces involving functions of self-adjoint operators with respect to the natural ordering of their associated quadratic forms. The relation between these results and Löwner’s Theorem is discussed. We also apply these results to complete a proof of the Wegner estimate for continuum models of random Schrödinger operators as given in a 1994 paper by Combes and Hislop.
Published: 2016

2. Trait‐dependent diversification in angiosperms: Patterns, models and data

Author: Andrew J. Helmstetter, Rosana Zenil-Ferguson, Hervé Sauquet, Sarah P. Otto, Marcos Méndez, Mario Vallejo-Marin, Jürg Schönenberger, Concetta Burgarella, Bruce Anderson, Hugo de Boer, Sylvain Glémin, Jos Käfer, Centre de Synthèse et d’Analyse sur la Biodiversité (CESAB), Fondation pour la recherche sur la Biodiversité (FRB), University of Kentucky (UK), University of New South Wales [Sydney] (UNSW), University of British Columbia [Vancouver], Universidad Rey Juan Carlos [Madrid] (URJC), Uppsala University, University of Vienna [Vienna], Stellenbosch University, Natural History Museum [Oslo], University of Oslo (UiO), Ecosystèmes, biodiversité, évolution [Rennes] (ECOBIO), Université de Rennes (UR)-Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR), Université de Rennes (UR)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Diversité, adaptation, développement des plantes (UMR DIADE), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM), and Fondation pour la recherche sur la biodiversité
Subjects: phylogenetics, flowering plants, macroevolution, trait evolution, speciation, BiSSE, extinction, [SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE], [SDE.BE]Environmental Sciences/Biodiversity and Ecology, [SDV.BV.BOT]Life Sciences [q-bio]/Vegetal Biology/Botanics, Ecology, Evolution, Behavior and Systematics
Abstract: Variation in species richness across the tree of life, accompanied by the incredible variety of ecological and morphological characteristics found in nature, has inspired many studies to link traits with species diversification. Angiosperms are a highly diverse group that has fundamentally shaped life on earth since the Cretaceous, and illustrate how species diversification affects ecosystem functioning. Numerous traits and processes have been linked to differences in species richness within this group, but we know little about how these interact and their relative importance. Here, we synthesized data from 152 studies that used state-dependent speciation and extinction (SSE) models on angiosperm clades. Intrinsic traits related to reproduction and morphology were often linked to diversification but a set of universal drivers did not emerge as traits did not have consistent effects across clades. Importantly, dataset properties were correlated to SSE model results - trees that were larger, older, or less well-sampled tended to yield trait-dependent outcomes. We compared these properties to recommendations for SSE model use and provide a set of best practices to follow when designing studies and reporting results. Finally, we argue that SSE model inferences should be considered in a larger context incorporating species’ ecology, demography and genetics.
Published: 2023

3. Band functions in presence of magnetic steps

Author: Nicolas Popoff, Mikael Persson Sundqvist, Nicolas Raymond, Peter D. Hislop, University of Kentucky, Department of Mathematics, University of Kentucky-University of Kentucky, Équipe EDP et Physique Mathématique, Institut de Mathématiques de Bordeaux (IMB), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS)-Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche Mathématique de Rennes (IRMAR), AGROCAMPUS OUEST, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-École normale supérieure - Rennes (ENS Rennes)-Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA), Department of Mathematics [Lund University], Lund University [Lund], University of Kentucky (UK)-University of Kentucky (UK), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1 (UB)-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS)-Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1 (UB)-Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux (Bordeaux INP)-Centre National de la Recherche Scientifique (CNRS), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École normale supérieure - Rennes (ENS Rennes)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-INSTITUT AGRO Agrocampus Ouest, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Institut de Mathématiques de Bordeaux ( IMB ), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1-Université de Bordeaux ( UB ) -Institut Polytechnique de Bordeaux ( Bordeaux INP ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1-Université de Bordeaux ( UB ) -Institut Polytechnique de Bordeaux ( Bordeaux INP ) -Centre National de la Recherche Scientifique ( CNRS ), Institut de Recherche Mathématique de Rennes ( IRMAR ), Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -AGROCAMPUS OUEST-École normale supérieure - Rennes ( ENS Rennes ) -Institut National de Recherche en Informatique et en Automatique ( Inria ) -Institut National des Sciences Appliquées ( INSA ) -Université de Rennes 2 ( UR2 ), and Université de Rennes ( UNIV-RENNES ) -Centre National de la Recherche Scientifique ( CNRS )
Subjects: [ MATH ] Mathematics [math], media_common.quotation_subject, Essential spectrum, 35J10, 35P20, 35Q60, 81Q10, 01 natural sciences, Asymmetry, Mathematics - Spectral Theory, Operator (computer programming), magnetic Schrödinger operators, Quantum mechanics, 0103 physical sciences, FOS: Mathematics, edge currents, 0101 mathematics, [MATH]Mathematics [math], Spectral Theory (math.SP), media_common, Mathematics, Applied Mathematics, 010102 general mathematics, 35J10, 81Q10, 35P20, Magnetic field, band functions, Discontinuity (linguistics), Modeling and Simulation, Piecewise, 010307 mathematical physics, Constant (mathematics), Asymptotic expansion
Abstract: International audience; We complete the analysis of the band functions for two-dimensional magnetic Schrödinger operators with piecewise constant magnetic fields. The discontinuity of the magnetic field can create edge currents that flow along the discontinuity that have been described by physicists. Properties of these edge currents are directly related to the behavior of the band functions. The effective potential of the fiber operator is an asymmetric double well (eventually degenerated) and the analysis of the splitting of the bands incorporates the asymmetry. If the magnetic field vanishes, the reduced operator has essential spectrum and we provide an explicit description of the band functions located below the essential spectrum. For non degenerate magnetic steps, we provide an asymptotic expansion of the band functions at infinity. We prove that when the ratio of the two magnetic fields is rational, a splitting of the band functions occurs and has a natural order, predicted by numerical computations.
Published: 2016

4. Stokes Problems in Irregular Domains with Various Boundary Conditions

Author: Zhongwei Shen, Sylvie Monniaux, Institut de Mathématiques de Marseille (I2M), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), University of Kentucky, Department of Mathematics, University of Kentucky-University of Kentucky, Yoshikazu Giga, Antonin Novotny, ANR-12-BS01-0013,HAB,Aux frontières de l'analyse Harmonique(2012), and University of Kentucky (UK)-University of Kentucky (UK)
Subjects: Operator (physics), Mathematical analysis, 010102 general mathematics, Mathematics::Analysis of PDEs, Boundary (topology), Fixed-point theorem, Lipschitz continuity, 01 natural sciences, Robin boundary condition, 010101 applied mathematics, Bounded function, [MATH.MATH-AP]Mathematics [math]/Analysis of PDEs [math.AP], Boundary value problem, 0101 mathematics, Stokes operator, Mathematics
Abstract: International audience; Different boundary conditions for the Navier-Stokes equations in bounded Lipschitz domains in ℝ 3 , such as Dirichlet, Neumann, Hodge or Robin boundary conditions are presented here. The situation is a little different from the case of smooth domains. The analysis of the problem involves a good comprehension of the behaviour near the boundary. The linear Stokes operator associated to the various boundary conditions is first studied. Then a classical fixed point theorem is used to show how the properties of the operator lead to local solutions or global solutions for small initial data.
Published: 2016

5. Impacts of nutrient addition on soil carbon and nitrogen stoichiometry and stability in globally-distributed grasslands

Author: Katherine S. Rocci, Kaydee S. Barker, Eric W. Seabloom, Elizabeth T. Borer, Sarah E. Hobbie, Jonathan D. Bakker, Andrew S. MacDougall, Rebecca L. McCulley, Joslin L. Moore, Xavier Raynaud, Carly J. Stevens, M. Francesca Cotrufo, Colorado State University [Fort Collins] (CSU), University of Minnesota [Twin Cities] (UMN), University of Minnesota System, University of Washington [Seattle], University of Guelph, University of Kentucky, Monash University [Clayton], Institut d'écologie et des sciences de l'environnement de Paris (iEES Paris ), Institut de Recherche pour le Développement (IRD)-Sorbonne Université (SU)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Lancaster University, This material is based upon work supported by the National Science Foundation Graduate Research Fellowship Program under Grant No. #1650114. This work has benefited from technical and human resources provided by CEREEP-Ecotron IleDeFrance (CNRS/ENS UMS 3194) as well as financial support from the Regional Council of Ile-de-France under the DIM Program R2DS bearing the reference I-05-098/R., Coordination and data management have been supported by funding to E. Borer and E. Seabloom from the National Science Foundation Research Coordination Network (NSF-DEB-1042132) and Long Term Ecological Research (NSF-DEB-1234162 and NSF-DEB-1831944 to Cedar Creek LTER) programs, and the Institute on the Environment (DG-0001-13). We also thank the Minnesota Supercomputer Institute for hosting project data and the Institute on the Environment for hosting Network meetings. Soil analyses were supported, in part, by USDA-ARS Grant 58-3098-7-007 to ETB., ANR-11-INBS-0001,ANAEE-FR,ANAEE-Services(2011), ANR-10-IDEX-0001,PSL,Paris Sciences et Lettres(2010), and University of Kentucky (UK)
Subjects: Soil organic matter, Nitrogen, Nutrient addition, Nutrient network (NutNet), Particulate organic matter, Grasslands, [SDE]Environmental Sciences, Phosphorous, Potassium, Environmental Chemistry, Mineral-associated organic matter, Earth-Surface Processes, Water Science and Technology
Abstract: Global changes will modify future nutrient availability with implications for grassland biogeochemistry. Soil organic matter (SOM) is central to grasslands for both provision of nutrients and climate mitigation through carbon (C) storage. While we know that C and nitrogen (N) in SOM can be influenced by greater nutrient availability, we lack understanding of nutrient effects on C and N coupling and stability in soil. Different SOM fractions have different functional relevance and mean residence times, i.e., mineral-associated organic matter (MAOM) has a higher mean residence time than particulate organic matter (POM). By separating effects of nutrient supply on the different SOM fractions, we can better evaluate changes in soil C and N coupling and stability and associated mechanisms. To this end, we studied responses of C and N ratios and distributions across POM and MAOM to 6–10 years of N, phosphorus (P), potassium and micronutrients (K +µ), and combined NPK +µ additions at 11 grassland sites spanning 3 continents and globally relevant environmental gradients in climate, plant growth, soil texture, and nutrient availability. We found addition of N and NPK +µ generally reduced C:N in MAOM and POM. However, at low fertility and at warm, sandy sites, nutrient addition promoted higher MAOM and POM C:N, respectively. Addition of NPK +µ also promoted C storage in POM relative to MAOM, and this was consistent across sites. Our results suggest that addition of macro- and micronutrients consistently decrease SOM stabilization, whereas responses of soil C:N stoichiometry were contingent on SOM fraction and environmental conditions.
Published: 2022

6. Human physiology adaptation to altered gravity environments

Author: Gilles Clément, Andrew P. Blaber, Olivier White, Jack J. W. A. van Loon, Nandu Goswami, Joyce M. Evans, Medical University Graz, Mohammed Bin Rashid University of Medicine and Health Sciences (MBRU), Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] (CAPS), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM), Simon Fraser University (SFU.ca), University of Kentucky (UK), Vrije Universiteit Amsterdam [Amsterdam] (VU), Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Clement, Gilles, University of Kentucky, Centre de recherche en neurosciences de Lyon (CRNL), and Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Gravity (chemistry), [SDV.MHEP.PHY] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Computer science, Aerospace Engineering, Hypergravity, Spaceflight, law.invention, Gravitation, [SCCO]Cognitive science, 03 medical and health sciences, 0302 clinical medicine, law, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Hypogravity, 030304 developmental biology, Cognitive science, 0303 health sciences, [SCCO] Cognitive science, Human physiology, Deconditioning, Artificial gravity, Sex, Microgravity, Adaptation, Centrifuge, 030217 neurology & neurosurgery
Abstract: International audience; Multiple transitions between gravity levels will occur during planetary exploration missions. In reaction to these gravitational transitions, physiological adaptation will be initiated. However, the physiological effects of longduration exposures to hypogravity and hypergravity are poorly understood. In this review we present an overview of how humans perceive gravity, review sex-based differences in adaptation to changes in gravity, and introduces rather limited evidence currently available related to the effects of partial gravity. The paper then argues that there is a need for more research to better understand the extent and dynamics of physiological adaptation mechanisms during gravity level transitions in spaceflight and proposes a need for artificial gravity (AG) as a multi-system countermeasure and explore the efficacy of AG as countermeasure between short and very long-arm centrifuges. Discussed here are the effects of acute short-arm AG application. The topical review also discusses the usage of chronic AG application via the innovative large-radius Hypergravity Human Habitat, H 3 , concept.
Published: 2021

7. Edge currents and eigenvalue estimates for magnetic barrier Schr\'odinger operators

Author: Nicolas Dombrowski, Peter D. Hislop, Eric Soccorsi, Department of Mathematics, University of Kentucky, University of Kentucky-University of Kentucky, Centre de Physique Théorique - UMR 7332 (CPT), Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), and University of Kentucky (UK)-University of Kentucky (UK)
Subjects: magnetic edge states, edge conductance, General Mathematics, 010102 general mathematics, Essential spectrum, Mathematical analysis, magnetic field, Absolute continuity, Mathematics::Spectral Theory, 01 natural sciences, Magnetic field, magnetic Schrödinger operators, Effective mass (solid-state physics), Operator (computer programming), [MATH.MATH-MP]Mathematics [math]/Mathematical Physics [math-ph], 0103 physical sciences, Direct integral, AMS 2000: 35J10, 81Q10, 35P20, 010307 mathematical physics, 0101 mathematics, snake orbits, Eigenvalues and eigenvectors, Harmonic oscillator, Mathematical Physics, Mathematics
Abstract: International audience; We study two-dimensional magnetic Schrödinger operators with a magnetic field that is equal to b>0 for x > 0 and (-b) for x < 0. This magnetic Schrödinger operator exhibits a magnetic barrier at x=0. The unperturbed system is invariant with respect to translations in the y-direction. As a result, the Schrödinger operator admits a direct integral decomposition. We analyze the band functions of the fiber operators as functions of the wave number and establish their asymptotic behavior. Because the fiber operators are reflection symmetric, the band functions may be classified as odd or even. The odd band functions have a unique absolute minimum. We calculate the effective mass at the minimum and prove that it is positive. The even band functions are monotone decreasing. We prove that the eigenvalues of an Airy operator, respectively, harmonic oscillator operator, describe the asymptotic behavior of the band functions for large negative, respectively positive, wave numbers. We prove a Mourre estimate for perturbations of the magnetic Schrödinger operator and establish the existence of absolutely continuous spectrum in certain energy intervals. We prove lower bounds on magnetic edge currents for states with energies in the same intervals. We also prove that these lower bounds imply stable lower bounds for the asymptotic currents. We study the perturbation by slowly decaying negative potentials and establish the asymptotic behavior of the eigenvalue counting function for the infinitely-many eigenvalues below the bottom of the essential spectrum.
Published: 2013

8. Edge states induced by Iwatsuka Hamiltonians with positive magnetic fields

Author: Eric Soccorsi, Peter D. Hislop, University of Kentucky, Department of Mathematics, University of Kentucky-University of Kentucky, Centre de Physique Théorique - UMR 7332 (CPT), Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), and University of Kentucky (UK)-University of Kentucky (UK)
Subjects: magnetic edge states, FOS: Physical sciences, magnetic field, Schödinger operators, asymptotic velocity, 01 natural sciences, Upper and lower bounds, symbols.namesake, magnetic barrier, Mathematics - Analysis of PDEs, [MATH.MATH-MP]Mathematics [math]/Mathematical Physics [math-ph], 0103 physical sciences, FOS: Mathematics, [MATH.MATH-AP]Mathematics [math]/Analysis of PDEs [math.AP], Edge states, 0101 mathematics, Mathematical Physics, Mathematics, Condensed matter physics, Magnetic barrier, Applied Mathematics, 010102 general mathematics, Mathematical Physics (math-ph), Magnetic field, 35J10, 81Q10, 35P20, Bounded function, symbols, 010307 mathematical physics, Hamiltonian (quantum mechanics), Analysis, Schrödinger's cat, Analysis of PDEs (math.AP)
Abstract: We study purely magnetic Schrodinger operators in two dimensions ( x , y ) with magnetic fields b ( x ) that depend only on the x-coordinate. The magnetic field b ( x ) is assumed to be bounded, there are constants 0 b − b + ∞ such that b − ≤ b ( x ) ≤ b + , and outside of a strip of small width − ϵ x ϵ , where 0 ϵ b − − 1 / 2 , we have b ( x ) = b ± x for ± x > ϵ . The case of a jump in the magnetic field at x = 0 corresponding to ϵ = 0 is also studied. We prove that the magnetic field creates an effective barrier near x = 0 that causes edge currents to flow along it consistent with the classical interpretation. We prove lower bounds on edge currents carried by states with energy localized inside the energy bands of the Hamiltonian. We prove that these edge current-carrying states are well-localized in x to a region of size b − − 1 / 2 , also consistent with the classical interpretation. We demonstrate that the edge currents are stable with respect to various magnetic and electric perturbations. These lower bounds on the edge current hold for all time. For a family of perturbations compactly supported in the y-direction, we prove that the time asymptotic current exists and satisfies the same lower bound.
Published: 2013
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9. A comprehensive phylogeny and revised taxonomy illuminate the origin and diversification of the global radiation of Papilio (Lepidoptera: Papilionidae)

Author: Condamine, Fabien, Allio, Rémi, Reboud, Eliette, Dupuis, Julian, Toussaint, Emmanuel, Mazet, Nathan, Hu, Shao-Ji, Lewis, Delano, Kunte, Krushnamegh, Cotton, Adam, Sperling, Felix, Institut des Sciences de l'Evolution de Montpellier (UMR ISEM), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Centre de Biologie pour la Gestion des Populations (UMR CBGP), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Montpellier, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Université de Montpellier (UM), University of Kentucky (UK), Museum d'Histoire Naturelle [Genève] (MHN), Yunnan Agricultural University, Burman University, Tata Institute of Fundamental Research [Bangalore], National Centre for Biological Sciences [TIFR] (NCBS), Tata Institute for Fundamental Research (TIFR), Chercheur indépendant, University of Alberta, This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (project GAIA, agreement no. 851188), and an ‘Investissement d’Avenir’ grant from the Agence Nationale de la Recherche (project CASMA, CEBA, ref. ANR-10-LABX-0025) to F.L.C., a Ramanujan Fellowship from the Dept. of Science and Technology, Govt. of India, to K.K., and support of the Dept. of Atomic Energy, Govt. of India, under project nos. 12-RandD-TFR-5.04-0800 and 12-RandD-TFR-5.04-0900 to TIFR/NCBS, a Natural Sciences and Engineering Research Council of Canada (NSERC) Discovery Grant to F.A.H.S. Sequencing of most Indian Papilio was done at NCBS under research and voucher specimen collection permits issued to K.K. by the state forest departments in Kerala (permit no. WL 10-3781/2012 dated 18/12/2012, and GO (RT) No. 376/2012/FandWLD dated 26/07/2012) and Nagaland (permit no. CWL/GEN/240/522-39 dated 14 August 2012). Alberto Fracasso (Italy) and Laurie Wills (New Zealand) are thanked for providing samples of some hard to obtain taxa., ANR-10-LABX-0025,CEBA,CEnter of the study of Biodiversity in Amazonia(2010), and European Project: 851188,GAIA
Subjects: [SDV.BA.ZI]Life Sciences [q-bio]/Animal biology/Invertebrate Zoology, [SDV.GEN.GPO]Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE], Systematics, Genetics, Macroevolution, Paleotropics, Butterflies, Molecular Biology, Historical biogeography, Ecology, Evolution, Behavior and Systematics, Taxonomy
Abstract: International audience; Highlights:• A dense and robust phylogeny of Papilio is reconstructed with seven DNA markers.• A taxonomic working list is proposed, including 235 extant species• Papilio originated in the Oligocene in a northern region centered on the Bering Land Bridge• The role of Paleotropics is revealed within the radiation of Old World Papilio• Synchronous southward dispersals explained the current tropical distribution of PapilioAbstract:The swallowtail genus Papilio (Lepidoptera: Papilionidae) is species rich, distributed worldwide, and has broad morphological habits and ecological niches. Because of its elevated species richness, it has been historically difficult to reconstruct a densely sampled phylogeny for this clade. Here we provide a taxonomic working list for the genus, resulting in 235 Papilio species, and assemble a molecular dataset of seven gene fragments representing ca. 80% of the currently described diversity. Phylogenetic analyses reconstructed a robust tree with highly supported relationships within subgenera, although a few nodes in the early history of the Old World Papilio remain unresolved. Contrasting with previous results, we found that Papilio alexanor is sister to all Old World Papilio and that the subgenus Eleppone is no longer monotypic. The latter includes the recently described Fijian Papilio natewa with the Australian Papilio anactus and is sister to subgenus Araminta (formerly included in subgenus Menelaides) occurring in Southeast Asia. Our phylogeny also includes rarely studied (P. antimachus, P. benguetana) or endangered species (P. buddha, P. chikae). Taxonomic changes resulting from this study are elucidated. Molecular dating and biogeographic analyses indicate that Papilio originated ca. 30 million years ago (Oligocene), in a northern region centered on Beringia. A rapid early Miocene radiation in the Paleotropics is revealed within Old World Papilio, potentially explaining their low early branch support. Most subgenera originated in the early to middle Miocene followed by synchronous southward biogeographic dispersals and repeated local extirpations in northern latitudes. This study provides a comprehensive phylogenetic framework for Papilio with clarification of subgeneric systematics and species taxonomic changes enumerated, which will facilitate further studies to address questions on their ecology and evolutionary biology using this model clade.
Published: 2023

10. Predicting attitudinal and behavioral responses to COVID-19 pandemic using machine learning

Author: Tomislav Pavlović, Flavio Azevedo, Koustav De, Julián C Riaño-Moreno, Marina Maglić, Theofilos Gkinopoulos, Patricio Andreas Donnelly-Kehoe, César Payán-Gómez, Guanxiong Huang, Jaroslaw Kantorowicz, Michèle D Birtel, Philipp Schönegger, Valerio Capraro, Hernando Santamaría-García, Meltem Yucel, Agustin Ibanez, Steve Rathje, Erik Wetter, Dragan Stanojević, Jan-Willem van Prooijen, Eugenia Hesse, Christian T Elbaek, Renata Franc, Zoran Pavlović, Panagiotis Mitkidis, Aleksandra Cichocka, Michele Gelfand, Mark Alfano, Robert M Ross, Hallgeir Sjåstad, John B Nezlek, Aleksandra Cislak, Patricia Lockwood, Koen Abts, Elena Agadullina, David M Amodio, Matthew A J Apps, John Jamir Benzon Aruta, Sahba Besharati, Alexander Bor, Becky Choma, William Cunningham, Waqas Ejaz, Harry Farmer, Andrej Findor, Biljana Gjoneska, Estrella Gualda, Toan L D Huynh, Mostak Ahamed Imran, Jacob Israelashvili, Elena Kantorowicz-Reznichenko, André Krouwel, Yordan Kutiyski, Michael Laakasuo, Claus Lamm, Jonathan Levy, Caroline Leygue, Ming-Jen Lin, Mohammad Sabbir Mansoor, Antoine Marie, Lewend Mayiwar, Honorata Mazepus, Cillian McHugh, Andreas Olsson, Tobias Otterbring, Dominic Packer, Jussi Palomäki, Anat Perry, Michael Bang Petersen, Arathy Puthillam, Tobias Rothmund, Petra C Schmid, David Stadelmann, Augustin Stoica, Drozdstoy Stoyanov, Kristina Stoyanova, Shruti Tewari, Bojan Todosijević, Benno Torgler, Manos Tsakiris, Hans H Tung, Radu Gabriel Umbreș, Edmunds Vanags, Madalina Vlasceanu, Andrew J Vonasch, Yucheng Zhang, Mohcine Abad, Eli Adler, Hamza Alaoui Mdarhri, Benedict Antazo, F Ceren Ay, Mouhamadou El Hady Ba, Sergio Barbosa, Brock Bastian, Anton Berg, Michał Białek, Ennio Bilancini, Natalia Bogatyreva, Leonardo Boncinelli, Jonathan E Booth, Sylvie Borau, Ondrej Buchel, Chrissie Ferreira de Carvalho, Tatiana Celadin, Chiara Cerami, Hom Nath Chalise, Xiaojun Cheng, Luca Cian, Kate Cockcroft, Jane Conway, Mateo A Córdoba-Delgado, Chiara Crespi, Marie Crouzevialle, Jo Cutler, Marzena Cypryańska, Justyna Dabrowska, Victoria H Davis, John Paul Minda, Pamala N Dayley, Sylvain Delouvée, Ognjan Denkovski, Guillaume Dezecache, Nathan A Dhaliwal, Alelie Diato, Roberto Di Paolo, Uwe Dulleck, Jānis Ekmanis, Tom W Etienne, Hapsa Hossain Farhana, Fahima Farkhari, Kristijan Fidanovski, Terry Flew, Shona Fraser, Raymond Boadi Frempong, Jonathan Fugelsang, Jessica Gale, E Begoña García-Navarro, Prasad Garladinne, Kurt Gray, Siobhán M Griffin, Bjarki Gronfeldt, June Gruber, Eran Halperin, Volo Herzon, Matej Hruška, Matthias F C Hudecek, Ozan Isler, Simon Jangard, Frederik Jørgensen, Oleksandra Keudel, Lina Koppel, Mika Koverola, Anton Kunnari, Josh Leota, Eva Lermer, Chunyun Li, Chiara Longoni, Darragh McCashin, Igor Mikloušić, Juliana Molina-Paredes, César Monroy-Fonseca, Elena Morales-Marente, David Moreau, Rafał Muda, Annalisa Myer, Kyle Nash, Jonas P Nitschke, Matthew S Nurse, Victoria Oldemburgo de Mello, M Soledad Palacios-Galvez, Yafeng Pan, Zsófia Papp, Philip Pärnamets, Mariola Paruzel-Czachura, Silva Perander, Michael Pitman, Ali Raza, Gabriel Gaudencio Rêgo, Claire Robertson, Iván Rodríguez-Pascual, Teemu Saikkonen, Octavio Salvador-Ginez, Waldir M Sampaio, Gaia Chiara Santi, David Schultner, Enid Schutte, Andy Scott, Ahmed Skali, Anna Stefaniak, Anni Sternisko, Brent Strickland, Jeffrey P Thomas, Gustav Tinghög, Iris J Traast, Raffaele Tucciarelli, Michael Tyrala, Nick D Ungson, Mete Sefa Uysal, Dirk Van Rooy, Daniel Västfjäll, Joana B Vieira, Christian von Sikorski, Alexander C Walker, Jennifer Watermeyer, Robin Willardt, Michael J A Wohl, Adrian Dominik Wójcik, Kaidi Wu, Yuki Yamada, Onurcan Yilmaz, Kumar Yogeeswaran, Carolin-Theresa Ziemer, Rolf A Zwaan, Paulo Sergio Boggio, Ashley Whillans, Paul A M Van Lange, Rajib Prasad, Michal Onderco, Cathal O'Madagain, Tarik Nesh-Nash, Oscar Moreda Laguna, Emily Kubin, Mert Gümren, Ali Fenwick, Arhan S Ertan, Michael J Bernstein, Hanane Amara, Jay Joseph Van Bavel, Brain and Cognition, Public Administration, Pavlovic, Tomislav, Avezedo, Flávio, De, Koustav, Maglić, Marina, Donnelly-Kehoe, Patricio Andreas, Payán-Gómez, César, Van Bavel, Jay J., Schmid, Petra Claudia, Crouzevialle, Marie, Willardt, Robin, et al., Ivo Pilar Institute of Social Sciences, University of Cambridge [UK] (CAM), University of Kentucky (UK), Universidad El Bosque [Bogota], University of Crete [Heraklion] (UOC), Universidad del Rosario [Bogota], Universidad Nacional de Colombia [Bogotà] (UNAL), City University of Hong Kong [Hong Kong] (CUHK), Universiteit Leiden, University of Greenwich, University of St Andrews [Scotland], Middlesex University [London], Pontifical Xavierian University, Duke University [Durham], Universidad Adolfo Ibáñez [Santiago], University of California (UC), Trinity College Dublin, Stockholm School of Economics (SSE), University of Belgrade [Belgrade], Vrije Universiteit Amsterdam [Amsterdam] (VU), Universidad Mayor de San Andrés (UMSA), Aarhus University [Aarhus], University of Kent [Canterbury], Stanford University, Macquarie University, Norwegian School of Economics and Business Administration, SWPS University of Social Sciences and Humanities (SWPS), University of Birmingham [Birmingham], University of Oxford, Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Vysšaja škola èkonomiki = National Research University Higher School of Economics [Moscow] (HSE), University of Amsterdam [Amsterdam] (UvA), Sunway University [Malaysia], University of the Witwatersrand [Johannesburg] (WITS), University of Toronto, National University of Sciences and Technology [Islamabad] (NUST), Comenius University in Bratislava, Macedonian Academy of Sciences and Arts [Skopje, North Macedonia] (MASA), Universidad de Huelva, University of Southampton, BRAC University, The Hebrew University of Jerusalem (HUJ), Erasmus University Rotterdam, Kieskompas, Helsingin yliopisto = Helsingfors universitet = University of Helsinki, University of Vienna [Vienna], Reichman University [Herzliya], Aalto University, Universidad Nacional Autónoma de México = National Autonomous University of Mexico (UNAM), National Taiwan University [Taiwan] (NTU), HEMS School, BI Norwegian Business School [Oslo], University of Limerick (UL), Karolinska Institutet [Stockholm], University of Agder (UIA), Lehigh University [Bethlehem], Monk Prayogshala, Friedrich-Schiller-Universität = Friedrich Schiller University Jena [Jena, Germany], Eidgenössische Technische Hochschule Zürich - Swiss Federal Institute of Technology in Zürich (ETH Zurïch), University of Bayreuth, National School of Political and Administrative Studies (SNSPA), Plovdiv University 'Paisii Hilendarski', Indian Institute of Management Indore (IMM Indore), Institute of Social Sciences Belgrade, Queensland University of Technology [Brisbane] (QUT), Royal Holloway [University of London] (RHUL), University of London [London], National University of Political Studies and Public Administration, University of Latvia (LU), New York University [New York] (NYU), NYU System (NYU), University of Canterbury [Christchurch], Hebei University of Technology [Tianjin], Université Mohammed VI Polytechnique [Ben Guerir] (UM6P), AnsuR Technologies [Fornebu], Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD), Victoria University [Melbourne], University of Wrocław [Poland] (UWr), IMT Institute for Advanced Studies [Lucca], Université de Florence, Università degli Studi di Firenze = University of Florence (UniFI), London School of Economics and Political Science (LSE), TBS Education, Slovak Academy of Science [Bratislava] (SAS), Santa Catarina State University (UDESC), University of Bologna/Università di Bologna, Tribhuvan University, Shenzhen Univerisity [Shenzhen], University of Virginia, Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT), University of Western Ontario (UWO), Université de Rennes 2 (UR2), Laboratoire de Psychologie Sociale et Cognitive (LAPSCO), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), University of British Columbia (UBC), University of Queensland [Brisbane], Pennsylvania State University (Penn State), Penn State System, Westfälische Wilhelms-Universität Münster = University of Münster (WWU), The University of Sydney, University of Waterloo [Waterloo], University of North Carolina [Chapel Hill] (UNC), University of North Carolina System (UNC), University of Colorado [Boulder], University of Regensburg, Kyiv School of economic (KSE), Linköping University (LIU), Monash University [Clayton], Ansbach University of Applied Sciences, Ludwig Maximilian University [Munich] (LMU), Department of Management - London School of Economics and Political Science (LSE), Questrom School of Business, Boston University [Boston] (BU), Dublin City University [Dublin] (DCU), University of Auckland [Auckland], Maria Curie-Sklodowska University (UMCS), City University of New York [New York] (CUNY), University of Alberta, Australian National University (ANU), University of Silesia in Katowice, Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] (UCM), Zhejiang University, Mackenzie Presbyterian University [São Paulo] (UPM), NYU Department of Psychology [New-York University], NYU System (NYU)-NYU System (NYU), University of Turku, City College of New York [CUNY] (CCNY), University of Groningen [Groningen], Carleton University, Département d'Etudes Cognitives - ENS Paris (DEC), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Faculté de Gouvernance, Sciences Économiques et Sociales [UM6P] (FGSES), University College of London [London] (UCL), Susquehanna University, University of Antwerp (UA), University of Exeter, University of Koblenz-Landau, Nicolaus Copernicus University [Toruń], University of California [San Diego] (UC San Diego), Kyushu University, Kadir Has University (KHAS), Harvard Business School, Harvard University, Vidyasagar College For Women, Koç University, Hult International Business School, Boǧaziçi üniversitesi = Boğaziçi University [Istanbul], Penn State Abington, Pennsylvania Commonwealth System of Higher Education (PCSHE)-Penn State System, Communication Science, Network Institute, Communication Choices, Content and Consequences (CCCC), Social Psychology, IBBA, A-LAB, University of St Andrews. Philosophy, University of St Andrews. School of Psychology and Neuroscience, Pavlović, Tomislav [0000-0002-4470-3715], Azevedo, Flavio [0000-0001-9000-8513], De, Koustav [0000-0001-9562-0672], Riaño-Moreno, Julián C [0000-0003-4182-0550], Maglić, Marina [0000-0002-6851-4601], Gkinopoulos, Theofilos [0000-0003-1070-6245], Donnelly-Kehoe, Patricio Andreas [0000-0002-3738-9537], Payán-Gómez, César [0000-0002-0633-1332], Huang, Guanxiong [0000-0002-8588-1454], Kantorowicz, Jaroslaw [0000-0002-1186-5427], Birtel, Michèle D [0000-0002-2383-9197], Schönegger, Philipp [0000-0001-9930-487X], Capraro, Valerio [0000-0002-0579-0166], Santamaría-García, Hernando [0000-0001-9422-3579], Yucel, Meltem [0000-0002-7274-5971], Ibanez, Agustin [0000-0001-6758-5101], Rathje, Steve [0000-0001-6727-571X], Wetter, Erik [0000-0002-5821-6651], Stanojević, Dragan [0000-0002-3667-2461], van Prooijen, Jan-Willem [0000-0001-6236-0819], Hesse, Eugenia [0000-0002-9077-9833], Elbaek, Christian T [0000-0002-7039-4565], Franc, Renata [0000-0002-1909-2393], Pavlović, Zoran [0000-0002-9231-5100], Mitkidis, Panagiotis [0000-0002-9495-7369], Cichocka, Aleksandra [0000-0003-1703-1586], Alfano, Mark [0000-0001-5879-8033], Ross, Robert M [0000-0001-8711-1675], Sjåstad, Hallgeir [0000-0002-8730-1038], Nezlek, John B [0000-0003-4963-3637], Cislak, Aleksandra [0000-0002-9880-6947], Lockwood, Patricia [0000-0001-7195-9559], Abts, Koen [0000-0001-8546-8347], Agadullina, Elena [0000-0002-1505-1412], Amodio, David M [0000-0001-7746-0150], Apps, Matthew AJ [0000-0001-5793-2202], Aruta, John Jamir Benzon [0000-0003-4155-1063], Besharati, Sahba [0000-0003-2836-7982], Bor, Alexander [0000-0002-2624-9221], Choma, Becky [0000-0002-8286-8983], Ejaz, Waqas [0000-0002-2492-4115], Farmer, Harry [0000-0002-3684-0605], Findor, Andrej [0000-0002-5896-6989], Gjoneska, Biljana [0000-0003-1200-6672], Gualda, Estrella [0000-0003-0220-2135], Huynh, Toan LD [0000-0002-6653-7447], Imran, Mostak Ahamed [0000-0002-5101-3149], Israelashvili, Jacob [0000-0003-1289-223X], Kantorowicz-Reznichenko, Elena [0000-0001-8128-7290], Krouwel, André [0000-0003-0952-6028], Kutiyski, Yordan [0000-0003-0889-4232], Laakasuo, Michael [0000-0003-2826-6073], Lamm, Claus [0000-0002-5422-0653], Levy, Jonathan [0000-0003-1007-2393], Leygue, Caroline [0000-0002-0355-1030], Lin, Ming-Jen [0000-0002-7174-2226], Mansoor, Mohammad Sabbir [0000-0002-6541-3506], Marie, Antoine [0000-0002-7958-0153], Mayiwar, Lewend [0000-0003-1404-4779], Mazepus, Honorata [0000-0002-5005-9399], McHugh, Cillian [0000-0002-9701-3232], Olsson, Andreas [0000-0001-5272-7744], Otterbring, Tobias [0000-0002-0283-8777], Packer, Dominic [0000-0001-8420-6548], Palomäki, Jussi [0000-0001-6063-0926], Perry, Anat [0000-0003-2329-856X], Petersen, Michael Bang [0000-0002-6782-5635], Puthillam, Arathy [0000-0003-2426-8362], Rothmund, Tobias [0000-0003-2979-5129], Schmid, Petra C [0000-0002-9990-5445], Stadelmann, David [0000-0002-1211-9936], Stoica, Augustin [0000-0003-0585-1114], Stoyanov, Drozdstoy [0000-0002-9975-3680], Stoyanova, Kristina [0000-0001-8362-6444], Tewari, Shruti [0000-0003-1903-7252], Todosijević, Bojan [0000-0002-6116-993X], Torgler, Benno [0000-0002-9809-963X], Tsakiris, Manos [0000-0001-7753-7576], Tung, Hans H [0000-0001-5332-7582], Umbreș, Radu Gabriel [0000-0002-6121-4518], Vanags, Edmunds [0000-0003-1932-936X], Vlasceanu, Madalina [0000-0003-2138-1968], Vonasch, Andrew J [0000-0002-2784-5420], Zhang, Yucheng [0000-0001-9435-6734], Abad, Mohcine [0000-0002-4964-5411], Adler, Eli [0000-0002-9005-5536], Mdarhri, Hamza Alaoui [0000-0001-9831-6561], Antazo, Benedict [0000-0001-9993-8960], Ay, F Ceren [0000-0003-4444-2268], Ba, Mouhamadou El Hady [0000-0002-2707-1242], Barbosa, Sergio [0000-0003-1989-158X], Bastian, Brock [0000-0003-4619-3322], Berg, Anton [0000-0001-7143-762X], Białek, Michał [0000-0002-5062-5733], Bilancini, Ennio [0000-0002-2027-3992], Bogatyreva, Natalia [0000-0002-6024-2322], Boncinelli, Leonardo [0000-0003-0626-5133], Booth, Jonathan E [0000-0002-8563-4613], Borau, Sylvie [0000-0003-1564-0695], Buchel, Ondrej [0000-0002-0139-5513], de Carvalho, Chrissie Ferreira [0000-0002-1369-6188], Celadin, Tatiana [0000-0002-7743-3117], Cerami, Chiara [0000-0003-1974-3421], Chalise, Hom Nath [0000-0002-9301-6890], Cian, Luca [0000-0002-8051-1366], Cockcroft, Kate [0000-0002-6166-8050], Conway, Jane [0000-0003-3883-349X], Córdoba-Delgado, Mateo A [0000-0002-2264-7388], Crespi, Chiara [0000-0002-7851-9887], Crouzevialle, Marie [0000-0002-5538-6030], Cutler, Jo [0000-0003-1073-764X], Cypryańska, Marzena [0000-0001-9234-562X], Dabrowska, Justyna [0000-0002-8821-7161], Davis, Victoria H [0000-0002-7207-4629], Minda, John Paul [0000-0002-4081-010X], Dayley, Pamala N [0000-0001-8955-9502], Delouvée, Sylvain [0000-0002-4029-597X], Denkovski, Ognjan [0000-0002-9739-4100], Dezecache, Guillaume [0000-0002-9366-6287], Dhaliwal, Nathan A [0000-0002-4667-0689], Di Paolo, Roberto [0000-0002-6081-6656], Dulleck, Uwe [0000-0002-0953-5963], Ekmanis, Jānis [0000-0003-1781-1785], Etienne, Tom W [0000-0002-4299-6593], Farkhari, Fahima [0000-0002-8484-5128], Fidanovski, Kristijan [0000-0002-9006-0140], Flew, Terry [0000-0003-4485-9338], Fraser, Shona [0000-0003-1505-0652], Frempong, Raymond Boadi [0000-0002-4603-5570], Fugelsang, Jonathan [0000-0002-6342-7023], Gale, Jessica [0000-0001-5677-8629], García-Navarro, E Begoña [0000-0001-6913-8882], Gray, Kurt [0000-0001-5816-2676], Griffin, Siobhán M [0000-0002-3613-2844], Gronfeldt, Bjarki [0000-0001-9941-7903], Gruber, June [0000-0002-7789-1353], Halperin, Eran [0000-0002-3379-2935], Herzon, Volo [0000-0001-7781-1651], Hruška, Matej [0000-0002-4521-3697], Hudecek, Matthias FC [0000-0002-7696-766X], Isler, Ozan [0000-0002-4638-2230], Jangard, Simon [0000-0002-7876-4161], Jørgensen, Frederik [0000-0002-5461-912X], Keudel, Oleksandra [0000-0001-6322-3103], Koppel, Lina [0000-0002-6302-0047], Koverola, Mika [0000-0001-8227-6120], Kunnari, Anton [0000-0002-2951-6399], Leota, Josh [0000-0002-7714-4630], Lermer, Eva [0000-0002-6600-9580], Li, Chunyun [0000-0001-5909-0889], Longoni, Chiara [0000-0002-4945-4957], McCashin, Darragh [0000-0003-2686-2111], Mikloušić, Igor [0000-0002-6539-2901], Monroy-Fonseca, César [0000-0003-4696-8159], Morales-Marente, Elena [0000-0002-1227-9606], Moreau, David [0000-0002-1957-1941], Muda, Rafał [0000-0003-4953-6642], Myer, Annalisa [0000-0002-2363-4757], Nash, Kyle [0000-0003-0461-3835], Nitschke, Jonas P [0000-0002-3244-8585], Nurse, Matthew S [0000-0003-1787-5914], de Mello, Victoria Oldemburgo [0000-0003-2867-8529], Palacios-Galvez, Maria Soledad [0000-0002-6802-6202], Pan, Yafeng [0000-0002-5633-8313], Papp, Zsófia [0000-0001-6257-0568], Pärnamets, Philip [0000-0001-8360-9097], Paruzel-Czachura, Mariola [0000-0002-8716-9778], Perander, Silva [0000-0001-6711-8079], Pitman, Michael [0000-0001-5532-5388], Raza, Ali [0000-0002-2438-6054], Rêgo, Gabriel Gaudencio [0000-0003-3304-4723], Robertson, Claire [0000-0001-8403-6358], Rodríguez-Pascual, Iván [0000-0002-5385-3643], Saikkonen, Teemu [0000-0001-9619-3270], Salvador-Ginez, Octavio [0000-0002-1652-8788], Sampaio, Waldir M [0000-0002-6066-4314], Santi, Gaia Chiara [0000-0002-9253-6122], Schultner, David [0000-0003-2253-4065], Schutte, Enid [0000-0002-6653-5409], Scott, Andy [0000-0002-3294-0078], Skali, Ahmed [0000-0002-4753-3280], Stefaniak, Anna [0000-0002-1706-7784], Sternisko, Anni [0000-0002-2507-3076], Strickland, Brent [0000-0002-7573-3722], Thomas, Jeffrey P [0000-0002-5939-5559], Tinghög, Gustav [0000-0002-8159-1249], Tucciarelli, Raffaele [0000-0002-0342-308X], Tyrala, Michael [0000-0001-5268-8319], Ungson, Nick D [0000-0003-2494-4498], Uysal, Mete Sefa [0000-0002-8698-9213], Van Rooy, Dirk [0000-0003-2525-5408], Västfjäll, Daniel [0000-0003-2873-4500], Vieira, Joana B [0000-0001-7335-4588], von Sikorski, Christian [0000-0002-3787-8277], Walker, Alexander C [0000-0003-1431-6770], Watermeyer, Jennifer [0000-0001-7918-8832], Willardt, Robin [0000-0002-2495-3450], Wohl, Michael JA [0000-0001-6945-5562], Wójcik, Adrian Dominik [0000-0002-7073-6019], Wu, Kaidi [0000-0001-6881-7437], Yamada, Yuki [0000-0003-1431-568X], Yilmaz, Onurcan [0000-0002-6094-7162], Yogeeswaran, Kumar [0000-0002-1978-5077], Ziemer, Carolin-Theresa [0000-0002-0794-7702], Zwaan, Rolf A [0000-0001-9967-7879], Boggio, Paulo Sergio [0000-0002-6109-0447], Van Lange, Paul AM [0000-0001-7774-6984], Prasad, Rajib [0000-0003-0913-1624], Onderco, Michal [0000-0001-9911-3782], O'Madagain, Cathal [0000-0002-4086-524X], Nesh-Nash, Tarik [0000-0002-5532-9095], Kubin, Emily [0000-0003-0606-8594], Gümren, Mert [0000-0002-3298-6295], Fenwick, Ali [0000-0002-5412-9745], Ertan, Arhan S [0000-0001-9730-8391], Bernstein, Michael J [0000-0002-8083-9839], Amara, Hanane [0000-0003-0732-2320], Van Bavel, Jay Joseph [0000-0002-2520-0442], Apollo - University of Cambridge Repository, Sociale Psychologie (Psychologie, FMG), ASCoR Other Research (FMG), Department of Neuroscience and Biomedical Engineering, Aalto-yliopisto, Department of Digital Humanities, Department of Psychology and Logopedics, Cognitive Science, High Performance Cognition group, Mind and Matter, and Department of Computer Science
Subjects: Hälso- och sjukvårdsorganisation, hälsopolitik och hälsoekonomi, Economics, COVID-19, social distancing, hygiene, policy support, public health measures, J Political Science, [SHS.PSY]Humanities and Social Sciences/Psychology, psychology, Settore SECS-P/02 - Politica Economica, Q1, H Social Sciences, [STAT.ML]Statistics [stat]/Machine Learning [stat.ML], SDG 3 - Good Health and Well-being, RA0421, RA0421 Public health. Hygiene. Preventive Medicine, Machine learning, Psychology, Nationalekonomi, Settore SECS-P/01 - Economia Politica, MCC, Computer. Automation, Psykologi (exklusive tillämpad psykologi), DAS, Health Care Service and Management, Health Policy and Services and Health Economy, [SHS.SCIPO]Humanities and Social Sciences/Political science, Psychology (excluding Applied Psychology), machine learning, Settore SECS-P/03 - Scienza delle Finanze, 5171 Political Science, Human medicine, COVID-19, social distancing, hygiene, policy support, public health measures
Abstract: At the beginning of 2020, COVID-19 became a global problem. Despite all the efforts to emphasize the relevance of preventive measures, not everyone adhered to them. Thus, learning more about the characteristics determining attitudinal and behavioral responses to the pandemic is crucial to improving future interventions. In this study, we applied machine learning on the multinational data collected by the International Collaboration on the Social and Moral Psychology of COVID-19 (N = 51,404) to test the predictive efficacy of constructs from social, moral, cognitive, and personality psychology, as well as socio-demographic factors, in the attitudinal and behavioral responses to the pandemic. The results point to several valuable insights. Internalized moral identity provided the most consistent predictive contribution—individuals perceiving moral traits as central to their self-concept reported higher adherence to preventive measures. Similar results were found for morality as cooperation, symbolized moral identity, self-control, open-mindedness, and collective narcissism, while the inverse relationship was evident for the endorsement of conspiracy theories. However, we also found a non-neglible variability in the explained variance and predictive contributions with respect to macro-level factors such as the pandemic stage or cultural region. Overall, the results underscore the importance of morality-related and contextual factors in understanding adherence to public health recommendations during the pandemic., PNAS Nexus, 1 (3), ISSN:2752-6542
Published: 2022

11. International electronic health record-derived post-acute sequelae profiles of COVID-19 patients

Author: Harrison G, Zhang, Arianna, Dagliati, Zahra, Shakeri Hossein Abad, Xin, Xiong, Clara-Lea, Bonzel, Zongqi, Xia, Bryce W Q, Tan, Paul, Avillach, Gabriel A, Brat, Chuan, Hong, Michele, Morris, Shyam, Visweswaran, Lav P, Patel, Alba, Gutiérrez-Sacristán, David A, Hanauer, John H, Holmes, Malarkodi Jebathilagam, Samayamuthu, Florence T, Bourgeois, Sehi, L'Yi, Sarah E, Maidlow, Bertrand, Moal, Shawn N, Murphy, Zachary H, Strasser, Antoine, Neuraz, Kee Yuan, Ngiam, Ne Hooi Will, Loh, Gilbert S, Omenn, Andrea, Prunotto, Lauren A, Dalvin, Jeffrey G, Klann, Petra, Schubert, Fernando J Sanz, Vidorreta, Vincent, Benoit, Guillaume, Verdy, Ramakanth, Kavuluru, Hossein, Estiri, Yuan, Luo, Alberto, Malovini, Valentina, Tibollo, Riccardo, Bellazzi, Kelly, Cho, Yuk-Lam, Ho, Amelia L M, Tan, Byorn W L, Tan, Nils, Gehlenborg, Sara, Lozano-Zahonero, Vianney, Jouhet, Luca, Chiovato, Bruce J, Aronow, Emma M S, Toh, Wei Gen Scott, Wong, Sara, Pizzimenti, Kavishwar B, Wagholikar, Mauro, Bucalo, Tianxi, Cai, Andrew M, South, Isaac S, Kohane, Griffin M, Weber, Admin, Oskar, Harvard Medical School [Boston] (HMS), Columbia University [New York], Università degli Studi di Pavia = University of Pavia (UNIPV), Harvard T.H. Chan School of Public Health, University of Pittsburgh (PITT), Pennsylvania Commonwealth System of Higher Education (PCSHE), National University Hospital [Singapore] (NUH), Duke University [Durham], University of Kansas Medical Center [Kansas City, KS, USA], University of Michigan Medical School [Ann Arbor], University of Michigan [Ann Arbor], University of Michigan System-University of Michigan System, University of Pennsylvania, University of Michigan System, CHU Bordeaux [Bordeaux], Massachusetts General Hospital [Boston], Université Paris Cité (UPCité), Service d'informatique médicale et biostatistiques [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), National University Health System [Singapore] (NUHS), University of Freiburg [Freiburg], Mayo Clinic [Rochester], VA Boston Healthcare System, University of California [Los Angeles] (UCLA), University of California (UC), University of Kentucky (UK), Northwestern University [Chicago, Ill. USA], Istituti Clinici Scientifici Maugeri [Pavia] (IRCCS Pavia - ICS Maugeri), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Cincinnati Children's Hospital Medical Center, National University of Singapore (NUS), Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, BIOMERIS [Pavia], Wake Forest School of Medicine [Winston-Salem], and Wake Forest Baptist Medical Center
Subjects: [SDV.MHEP.ME] Life Sciences [q-bio]/Human health and pathology/Emerging diseases, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, Health Information Management, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Medicine (miscellaneous), [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Health Informatics, Computer Science Applications
Abstract: The risk profiles of post-acute sequelae of COVID-19 (PASC) have not been well characterized in multi-national settings with appropriate controls. We leveraged electronic health record (EHR) data from 277 international hospitals representing 414,602 patients with COVID-19, 2.3 million control patients without COVID-19 in the inpatient and outpatient settings, and over 221 million diagnosis codes to systematically identify new-onset conditions enriched among patients with COVID-19 during the post-acute period. Compared to inpatient controls, inpatient COVID-19 cases were at significant risk for angina pectoris (RR 1.30, 95% CI 1.09–1.55), heart failure (RR 1.22, 95% CI 1.10–1.35), cognitive dysfunctions (RR 1.18, 95% CI 1.07–1.31), and fatigue (RR 1.18, 95% CI 1.07–1.30). Relative to outpatient controls, outpatient COVID-19 cases were at risk for pulmonary embolism (RR 2.10, 95% CI 1.58–2.76), venous embolism (RR 1.34, 95% CI 1.17–1.54), atrial fibrillation (RR 1.30, 95% CI 1.13–1.50), type 2 diabetes (RR 1.26, 95% CI 1.16–1.36) and vitamin D deficiency (RR 1.19, 95% CI 1.09–1.30). Outpatient COVID-19 cases were also at risk for loss of smell and taste (RR 2.42, 95% CI 1.90–3.06), inflammatory neuropathy (RR 1.66, 95% CI 1.21–2.27), and cognitive dysfunction (RR 1.18, 95% CI 1.04–1.33). The incidence of post-acute cardiovascular and pulmonary conditions decreased across time among inpatient cases while the incidence of cardiovascular, digestive, and metabolic conditions increased among outpatient cases. Our study, based on a federated international network, systematically identified robust conditions associated with PASC compared to control groups, underscoring the multifaceted cardiovascular and neurological phenotype profiles of PASC.
Published: 2022

12. A generalization of combinatorial identities for stable discrete series constants

Author: Richard Ehrenborg, Sophie Morel, Margaret Readdy, Department of Mathematics (Kentucky), University of Kentucky (UK), Unité de Mathématiques Pures et Appliquées (UMPA-ENSL), École normale supérieure de Lyon (ENS de Lyon)-Centre National de la Recherche Scientifique (CNRS), University of Kentucky, École normale supérieure - Lyon (ENS Lyon)-Centre National de la Recherche Scientifique (CNRS), and Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Lyon (ENS Lyon)
Subjects: Algebra and Number Theory, [MATH.MATH-RT]Mathematics [math]/Representation Theory [math.RT], [MATH.MATH-CO]Mathematics [math]/Combinatorics [math.CO], FOS: Mathematics, Mathematics - Combinatorics, Discrete Mathematics and Combinatorics, Combinatorics (math.CO), Primary 20F55, 17B22, 52C35, Secondary 52B45, 14G35, 14F43, 05E45, 06A07, 52B22, Representation Theory (math.RT), [MATH]Mathematics [math], Mathematics::Representation Theory, Mathematics - Representation Theory
Abstract: This article is concerned with the constants that appear in Harish-Chandra's character formula for stable discrete series of real reductive groups, although it does not require any knowledge about real reductive groups or discrete series. In Harish-Chandra's work the only information we have about these constants is that they are uniquely determined by an inductive property. Later Goresky-Kottwitz-MacPherson and Herb gave different formulas for these constants. In this article we generalize these formulas to the case of arbitrary finite Coxeter groups (in this setting, discrete series no longer make sense), and give a direct proof that the two formulas agree. We actually prove a slightly more general identity that also implies the combinatorial identity underlying the discrete series character identities of Morel. We deduce this identity from a general abstract theorem giving a way to calculate the alternating sum of the values of a valuation on the chambers of a Coxeter arrangement. We also introduce a ring structure on the set of valuations on polyhedral cones in Euclidean space with values in a fixed ring. This gives a theoretical framework for the valuation appearing in Appendix A of the Goresky-Kottwitz-MacPherson paper. In Appendix B we extend the notion of $2$-structures (due to Herb) to pseudo-root systems., 58 pages, 3 figures, 2 tables; to appear in the Journal of Combinatorial Algebra
Published: 2022

13. Preference for 50% reinforcement over 75% reinforcement by pigeons

Author: Thomas R. Zentall, Holly C. Miller, Jérôome J. D. Alessandri, Cassandra D. Gipson, Unité de Recherche en Sciences Cognitives et Affectives (URECA), Université de Lille, Sciences Humaines et Sociales-PRES Université Lille Nord de France, Université de Lille, CNRS, CHU Lille, University of Kentucky [UK], Unité de Recherche en Sciences Cognitives et Affectives [URECA], Alessandri, Jerome, University of Kentucky, and University of Kentucky (UK)
Subjects: Reinforcement Schedule, Cognitive Neuroscience, [SHS.PSY]Humanities and Social Sciences/Psychology, Experimental and Cognitive Psychology, Models, Psychological, Stimulus (physiology), Choice Behavior, Developmental psychology, [SHS.PSY] Humanities and Social Sciences/Psychology, Animals, Columbidae, Conditioning, Operant, Models, Psychological, Reinforcement, Psychology, [SCCO]Cognitive science, 03 medical and health sciences, Behavioral Neuroscience, 0302 clinical medicine, 0501 psychology and cognitive sciences, 050102 behavioral science & comparative psychology, ACL, 05 social sciences, Negative contrast, Positive contrast, Conditioning, Operant, Reinforcement, Psychology, 030217 neurology & neurosurgery, Cognitive psychology
Abstract: PMID: 19815925; International audience; When pigeons are given a choice between an initial-link alternative that results in either a terminal-link stimulus correlated with 100% reinforcement or a stimulus correlated with 0% reinforcement (overall 50% reinforcement) and another initial-link alternative that always results in a terminal-link stimulus correlated with 100% reinforcement, some pigeons show a preference for the initial-link alternative correlated with 50% reinforcement. Using this procedure, in Experiment 1, we found a relatively modest preference for 100% over 50% reinforcement. In Experiment 2, we decreased the reinforcement density for the second initial-link alternative to 75% and found a significant preference for the 50% reinforcement initial-link alternative. It may be that this "maladaptive" behavior results from a positive contrast between the expectation of reinforcement correlated with the 50% reinforcement initial-link alternative and the terminal-link stimulus correlated with 100% reinforcement. But apparently, the complementary negative contrast does not develop between the expectation of reinforcement correlated with the 50% reinforcement initial-link alternative and the terminal-link stimulus correlated with 0% reinforcement that often follow. Such paradoxical choice may account for certain human appetitive risk-taking behavior (e.g., gambling) as well.
Published: 2009

14. Opposing effects of plant traits on diversification

Author: Bruce Anderson, John Pannell, Sylvain Billiard, Concetta Burgarella, Hugo de Boer, Mathilde Dufay, Andrew J. Helmstetter, Marcos Méndez, Sarah P. Otto, Denis Roze, Hervé Sauquet, Daniel Schoen, Jürg Schönenberger, Mario Vallejo-Marin, Rosana Zenil-Ferguson, Jos Käfer, Sylvain Glémin, Stellenbosch University, Université de Lausanne = University of Lausanne (UNIL), Évolution, Écologie et Paléontologie (Evo-Eco-Paleo) - UMR 8198 (Evo-Eco-Paléo (EEP)), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Uppsala University, Natural History Museum [Oslo], University of Oslo (UiO), Centre d’Ecologie Fonctionnelle et Evolutive (CEFE), Université Paul-Valéry - Montpellier 3 (UPVM)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Montpellier, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Université de Montpellier (UM), Centre de Synthèse et d’Analyse sur la Biodiversité (CESAB), Fondation pour la recherche sur la Biodiversité (FRB), Universidad Rey Juan Carlos [Madrid] (URJC), University of British Columbia [Vancouver], Station biologique de Roscoff (SBR), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), University of New South Wales [Sydney] (UNSW), McGill University = Université McGill [Montréal, Canada], University of Vienna [Vienna], University of Kentucky (UK), Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Ecosystèmes, biodiversité, évolution [Rennes] (ECOBIO), Université de Rennes (UR)-Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR), Université de Rennes (UR)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS), Horizon 2020 Framework Programme, H2020, H2020 Marie Skłodowska-Curie Actions, MSCA: 839643, and Horizon 2020
Subjects: Plant biology, Biological sciences, Evolutionary theories, Multidisciplinary, Plant population biology, Perspective, Evolutionary biology, [SDE.BE]Environmental Sciences/Biodiversity and Ecology
Abstract: International audience; Species diversity can vary dramatically across lineages due to differences in speciation and extinction rates. Here, we explore the effects of several plant traits on diversification, finding that most traits have opposing effects on diversification. For example, outcrossing may increase the efficacy of selection and adaptation but also decrease mate availability, two processes with contrasting effects on lineage persistence. Such opposing trait effects can manifest as differences in diversification rates that depend on ecological context, spatiotemporal scale, and associations with other traits. The complexity of pathways linking traits to diversification suggests that the mechanistic underpinnings behind their correlations may be difficult to interpret with any certainty, and context dependence means that the effects of specific traits on diversification are likely to differ across multiple lineages and timescales. This calls for taxonomically and context-controlled approaches to studies that correlate traits and diversification. © 2023
Published: 2023

15. Preference for rewards that follow greater effort and greater delay

Author: Yvonne Delevoye-Turrell, Thomas R. Zentall, Jérôme Alessandri, Jean-Claude Darcheville, Alessandri, Jerome, Unité de Recherche en Sciences Cognitives et Affectives (URECA), Université de Lille, Sciences Humaines et Sociales-PRES Université Lille Nord de France, University of Kentucky, Université de Lille, CNRS, CHU Lille, Unité de Recherche en Sciences Cognitives et Affectives [URECA], University of Kentucky [UK], and University of Kentucky (UK)
Subjects: Male, medicine.medical_specialty, Time Factors, Cognitive Neuroscience, [SHS.PSY]Humanities and Social Sciences/Psychology, Experimental and Cognitive Psychology, Effort justification, Audiology, Choice Behavior, [SHS.PSY] Humanities and Social Sciences/Psychology, 03 medical and health sciences, Behavioral Neuroscience, Young Adult, [SCCO]Cognitive science, 0302 clinical medicine, Reward, medicine, Cognitive dissonance, Humans, 0501 psychology and cognitive sciences, 050102 behavioral science & comparative psychology, 10. No inequality, Reinforcement, Short duration, Motivation, ACL, 05 social sciences, Classical conditioning, Preference, Attitude, Duration (music), Female, Stimulus control, Psychology, Social psychology, 030217 neurology & neurosurgery
Abstract: PMID: 18927058; International audience; Humans prefer (conditioned) rewards that follow greater effort (Aronson & Mills, 1959). This phenomenon can be interpreted as evidence for cognitive dissonance (or as justification of effort) but may also result from (1) the contrast between the relatively greater effort and the signal for reinforcement or (2) the delay reduction signaled by the conditioned reinforcer. In the present study, we examined the effect of prior force and prior time to produce stimuli associated with equal reinforcement. As expected, pressing with greater force or for a longer time was less preferred than pressing with less force or for a shorter time. However, participants preferred the conditioned reinforcer that followed greater force and more time. Furthermore, participants preferred a long duration with no force requirement over a shorter duration with a high force requirement and, consistent with the contrast account but not with the delay reduction account, they preferred the conditioned stimulus that followed the less preferred, shorter duration, high-force event. Within-trial contrast provides a more parsimonious account than justification of effort, and a more complete account than delay reduction.
Published: 2008

16. Comparison of Nanomaterials for Delivery of Double-Stranded RNA in Caenorhabditis elegans

Author: Olga V. Tsyusko, Jérôme Laisney, Stuart S. Lichtenberg, Subba Reddy Palli, Armand Masion, Zeinah Elhaj Baddar, Clément Levard, Jason M. Unrine, University of Kentucky, Centre européen de recherche et d'enseignement des géosciences de l'environnement (CEREGE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), National Science Foundation (NSF) CBET-1712323Centre National de la Recherche Scientifique (CNRS) 08322United States Department of Health & Human Services National Institutes of Health (NIH) - USA P40 OD010440, and University of Kentucky (UK)
Subjects: layered double hydroxide, 0106 biological sciences, Peptide, 01 natural sciences, Marker gene, Nanomaterials, RNA interference, gene knockdown, Caenorhabditis elegans, nanomaterials, 2. Zero hunger, chemistry.chemical_classification, Gene knockdown, biology, Chemistry, 010401 analytical chemistry, General Chemistry, Double stranded rna, biology.organism_classification, 0104 chemical sciences, Cell biology, RNA silencing, imogolite, RNAi, [SDE]Environmental Sciences, General Agricultural and Biological Sciences, insecticides, cationic polymers, 010606 plant biology & botany
Abstract: International audience; RNA interference is a promising crop protection technology that has seen rapid development in the past several years. Here, we investigated polyamino acid biopolymers, inorganic nanomaterials, and hybrid organic–inorganic nanomaterials for delivery of dsRNA and efficacy of gene knockdown using the model nematode Caenorhabditis elegans. Using an oral route of delivery, we are able to approximate how nanomaterials will be delivered in the environment. Of the materials investigated, only Mg–Al layered double-hydroxide nanoparticles were effective at gene knockdown in C. elegans, reducing marker gene expression to 66.8% of that of the control at the lowest tested concentration. In addition, we identified previously unreported injuries to the mouthparts of C. elegans associated with the use of a common cell-penetrating peptide, poly-l-arginine. Our results will allow the pursuit of further research into promising materials for dsRNA delivery and also allow for the exclusion of those with little efficacy or deleterious effects.
Published: 2020

17. Annals of Forest Science promotes multidisciplinary research on forests and wood in a changing world and is now a full Open Access journal

Author: Erwin Dreyer, Jean Michel Leban, Shuguang Léo Liu, Andreas Bolte, John Lhotka, Marco Ferretti, Véronique Lesage, SILVA (SILVA), AgroParisTech-Université de Lorraine (UL)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Unité de recherche Biogéochimie des Ecosystèmes Forestiers (BEF), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Central South University of Forestry and Technology (CSUFT ), Johann Heinrich von Thünen Institut, University of Kentucky (UK), Swiss Federal Institute for Forest, Snow and Landscape Research WSL, Laboratoire de Physique et Physiologie Intégratives de l’Arbre en environnement Fluctuant (PIAF), and Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA)
Subjects: [SDV.SA.SF]Life Sciences [q-bio]/Agricultural sciences/Silviculture, forestry, Ecology, Forestry
Abstract: International audience
Published: 2022

18. National identity predicts public health support during a global pandemic

Author: Van Bavel, Jay J., Cichocka, Aleksandra, Capraro, Valerio, Sjåstad, Hallgeir, Nezlek, John B., Pavlović, Tomislav, Alfano, Mark, Gelfand, Michele J., Azevedo, Flavio, Birtel, Michèle D., Cislak, Aleksandra, Lockwood, Patricia L., Ross, Robert Malcolm, Abts, Koen, Agadullina, Elena, Aruta, John Jamir Benzon, Besharati, Sahba Nomvula, Bor, Alexander, Choma, Becky L., Crabtree, Charles David, Cunningham, William A., De, Koustav, Ejaz, Waqas, Elbaek, Christian T., Findor, Andrej, Flichtentrei, Daniel, Franc, Renata, Gjoneska, Biljana, Gruber, June, Gualda, Estrella, Horiuchi, Yusaku, Huynh, Toan Luu Duc, Ibanez, Agustin, Imran, Mostak Ahamed, Israelashvili, Jacob, Jasko, Katarzyna, Kantorowicz, Jaroslaw, Kantorowicz-Reznichenko, Elena, Krouwel, André, Laakasuo, Michael, Lamm, Claus, Leygue, Caroline, Lin, Ming-Jen, Mansoor, Mohammad Sabbir, Marie, Antoine, Mayiwar, Lewend, Mazepus, Honorata, McHugh, Cillian, Minda, John Paul, Mitkidis, Panagiotis, Olsson, Andreas, Otterbring, Tobias, Packer, Dominic J., Perry, Anat, Petersen, Michael Bang, Puthillam, Arathy, Riaño-Moreno, Julián C., Rothmund, Tobias, Santamaría-García, Hernando, Schmid, Petra C., Stoyanov, Drozdstoy, Tewari, Shruti, Todosijević, Bojan, Tsakiris, Manos, Tung, Hans H., Umbreș, Radu G., Vanags, Edmunds, Vlasceanu, Madalina, Vonasch, Andrew, Yucel, Meltem, Zhang, Yucheng, Abad, Mohcine, Adler, Eli, Akrawi, Narin, Mdarhri, Hamza Alaoui, Amara, Hanane, Amodio, David M., Antazo, Benedict G., Apps, Matthew, Ay, F. Ceren, Ba, Mouhamadou Hady, Barbosa, Sergio, Bastian, Brock, Berg, Anton, Bernal-Zárate, Maria P., Bernstein, Michael, Białek, Michał, Bilancini, Ennio, Bogatyreva, Natalia, Boncinelli, Leonardo, Booth, Jonathan E., Borau, Sylvie, Buchel, Ondrej, Cameron, C. Daryl, Carvalho, Chrissie F., Celadin, Tatiana, Cerami, Chiara, Chalise, Hom Nath, Cheng, Xiaojun, Cian, Luca, Cockcroft, Kate, Conway, Jane, Córdoba-Delgado, Mateo Andres, Crespi, Chiara, Crouzevialle, Marie, Cutler, Jo, Cypryańska, Marzena, Dabrowska, Justyna, Daniels, Michael A., Davis, Victoria H., Dayley, Pamala N., Delouvee, Sylvain, Denkovski, Ognjan, Dezecache, Guillaume, Dhaliwal, Nathan A., Diato, Alelie B., Di Paolo, Roberto, Drosinou, Marianna, Dulleck, Uwe, Ekmanis, Jānis, Ertan, Arhan S., Etienne, Tom W., Farhana, Hapsa Hossain, Farkhari, Fahima, Farmer, Harry, Fenwick, Ali, Fidanovski, Kristijan, Flew, Terry, Fraser, Shona, Frempong, Raymond Boadi, Fugelsang, Jonathan A., Gale, Jessica, Garcia-Navarro, E. Begoña, Garladinne, Prasad, Ghajjou, Oussama, Gkinopoulos, Theofilos, Gray, Kurt, Griffin, Siobhán M., Gronfeldt, Bjarki, Gümren, Mert, Gurung, Ranju Lama, Halperin, Eran, Harris, Elizabeth, Herzon, Volo, Hruška, Matej, Huang, Guanxiong, Hudecek, Matthias F. C., Isler, Ozan, Jangard, Simon, Jørgensen, Frederik J., Kachanoff, Frank, Kahn, John, Dangol, Apsara Katuwal, Keudel, Oleksandra, Koppel, Lina, Koverola, Mika, Kubin, Emily, Kunnari, Anton, Kutiyski, Yordan, Laguna, Oscar, Leota, Josh, Lermer, Eva, Levy, Jonathan, Levy, Neil, Li, Chunyun, Long, Elizabeth U., Longoni, Chiara, Maglić, Marina, McCashin, Darragh, Metcalf, Alexander L., Mikloušić, Igor, El Mimouni, Soulaimane, Miura, Asako, Molina-Paredes, Juliana, Monroy-Fonseca, César, Morales-Marente, Elena, Moreau, David, Muda, Rafał, Myer, Annalisa, Nash, Kyle, Nesh-Nash, Tarik, Nitschke, Jonas P., Nurse, Matthew S., Ohtsubo, Yohsuke, Oldemburgo De Mello, Victoria, O’Madagain, Cathal, Onderco, Michal, Palacios-Galvez, M. Soledad, Palomäki, Jussi, Pan, Yafeng, Papp, Zsófia, Pärnamets, Philip, Paruzel-Czachura, Mariola, Pavlović, Zoran, Payán-Gómez, César, Perander, Silva, Pitman, Michael Mark, Prasad, Rajib, Pyrkosz-Pacyna, Joanna, Rathje, Steve, Raza, Ali, Rêgo, Gabriel G., Rhee, Kasey, Robertson, Claire E., Rodríguez-Pascual, Iván, Saikkonen, Teemu, Salvador-Ginez, Octavio, Sampaio, Waldir M., Santi, Gaia C., Santiago-Tovar, Natalia, Savage, David, Scheffer, Julian A., Schönegger, Philipp, Schultner, David T., Schutte, Enid M., Scott, Andy, Sharma, Madhavi, Sharma, Pujan, Skali, Ahmed, Stadelmann, David, Stafford, Clara Alexandra, Stanojević, Dragan, Stefaniak, Anna, Sternisko, Anni, Stoica, Agustin, Stoyanova, Kristina K., Strickland, Brent, Sundvall, Jukka, Thomas, Jeffrey P., Tinghög, Gustav, Torgler, Benno, Traast, Iris J., Tucciarelli, Raffaele, Tyrala, Michael, Ungson, Nick D., Uysal, Mete S., Van Lange, Paul A. M., Van Prooijen, Jan-Willem, Van Rooy, Dirk, Västfjäll, Daniel, Verkoeijen, Peter, Vieira, Joana B., Von Sikorski, Christian, Walker, Alexander Cameron, Watermeyer, Jennifer, Wetter, Erik, Whillans, Ashley, Willardt, Robin, Wohl, Michael J. A., Wójcik, Adrian Dominik, Wu, Kaidi, Yamada, Yuki, Yilmaz, Onurcan, Yogeeswaran, Kumar, Ziemer, Carolin-Theresa, Zwaan, Rolf A., Boggio, Paulo S., Van Bavel, Jay J., Cichocka, Aleksandra, Capraro, Valerio, Sjåstad, Hallgeir, Nezlek, John B., Pavlović, Tomislav, Alfano, Mark, Gelfand, Michele J., Azevedo, Flavio, Birtel, Michèle D., Cislak, Aleksandra, Lockwood, Patricia L., Ross, Robert Malcolm, Abts, Koen, Agadullina, Elena, Aruta, John Jamir Benzon, Besharati, Sahba Nomvula, Bor, Alexander, Choma, Becky L., Crabtree, Charles David, Cunningham, William A., De, Koustav, Ejaz, Waqa, Elbaek, Christian T., Findor, Andrej, Flichtentrei, Daniel, Franc, Renata, Gjoneska, Biljana, Gruber, June, Gualda, Estrella, Horiuchi, Yusaku, Huynh, Toan Luu Duc, Ibanez, Augustin, Imran, Mostak Ahamed, Israelashvili, Jacob, Jasko, Katarzyna, Kantorowicz, Jaroslaw, Kantorowicz-Reznichenko, Elena, Krouwel, André, Laakasuo, Michael, Lamm, Clau, Leygue, Caroline, Lin, Ming-Jen, Mansoor, Mohammad Sabbir, Marie, Antoine, Mayiwar, Lewend, Mazepus, Honorata, McHugh, Cillian, Minda, John Paul, Mitkidis, Panagioti, Olsson, Andrea, Otterbring, Tobia, Packer, Dominic J., Perry, Anat, Petersen, Michael Bang, Puthillam, Arathy, Riaño-Moreno, Julián C., Rothmund, Tobia, Santamaría-García, Hernando, Schmid, Petra C., Stoyanov, Drozdstoy, Tewari, Shruti, Todosijević, Bojan, Tsakiris, Mano, Tung, Hans H., Umbreș, Radu G., Vanags, Edmund, Vlasceanu, Madalina, Vonasch, Andrew, Yucel, Meltem, Zhang, Yucheng, Abad, Mohcine, Adler, Eli, Akrawi, Narin, Mdarhri, Hamza Alaoui, Amara, Hanane, Amodio, David M., Antazo, Benedict G., Apps, Matthew, Ay, F. Ceren, Ba, Mouhamadou Hady, Barbosa, Sergio, Bastian, Brock, Berg, Anton, Bernal-Zárate, Maria P., Bernstein, Michael, Białek, Michał, Bilancini, Ennio, Bogatyreva, Natalia, Boncinelli, Leonardo, Booth, Jonathan E., Borau, Sylvie, Buchel, Ondrej, Cameron, C. Daryl, Carvalho, Chrissie F., Celadin, Tatiana, Cerami, Chiara, Chalise, Hom Nath, Cheng, Xiaojun, Cian, Luca, Cockcroft, Kate, Conway, Jane, Córdoba-Delgado, Mateo Andre, Crespi, Chiara, Crouzevialle, Marie, Cutler, Jo, Cypryańska, Marzena, Dabrowska, Justyna, Daniels, Michael A., Davis, Victoria H., Dayley, Pamala N., Delouvee, Sylvain, Denkovski, Ognjan, Dezecache, Guillaume, Dhaliwal, Nathan A., Diato, Alelie B., Di Paolo, Roberto, Drosinou, Marianna, Dulleck, Uwe, Ekmanis, Jāni, Ertan, Arhan S., Etienne, Tom W., Farhana, Hapsa Hossain, Farkhari, Fahima, Farmer, Harry, Fenwick, Ali, Fidanovski, Kristijan, Flew, Terry, Fraser, Shona, Frempong, Raymond Boadi, Fugelsang, Jonathan A., Gale, Jessica, Garcia-Navarro, E. Begoña, Garladinne, Prasad, Ghajjou, Oussama, Gkinopoulos, Theofilo, Gray, Kurt, Griffin, Siobhán M., Gronfeldt, Bjarki, Gümren, Mert, Gurung, Ranju Lama, Halperin, Eran, Harris, Elizabeth, Herzon, Volo, Hruška, Matej, Huang, Guanxiong, Hudecek, Matthias F. C., Isler, Ozan, Jangard, Simon, Jørgensen, Frederik J., Kachanoff, Frank, Kahn, John, Dangol, Apsara Katuwal, Keudel, Oleksandra, Koppel, Lina, Koverola, Mika, Kubin, Emily, Kunnari, Anton, Kutiyski, Yordan, Laguna, Oscar, Leota, Josh, Lermer, Eva, Levy, Jonathan, Levy, Neil, Li, Chunyun, Long, Elizabeth U., Longoni, Chiara, Maglić, Marina, McCashin, Darragh, Metcalf, Alexander L., Mikloušić, Igor, El Mimouni, Soulaimane, Miura, Asako, Molina-Paredes, Juliana, Monroy-Fonseca, César, Morales-Marente, Elena, Moreau, David, Muda, Rafał, Myer, Annalisa, Nash, Kyle, Nesh-Nash, Tarik, Nitschke, Jonas P., Nurse, Matthew S., Ohtsubo, Yohsuke, Oldemburgo de Mello, Victoria, O’Madagain, Cathal, Onderco, Michal, Palacios-Galvez, M. Soledad, Palomäki, Jussi, Pan, Yafeng, Papp, Zsófia, Pärnamets, Philip, Paruzel-Czachura, Mariola, Pavlović, Zoran, Payán-Gómez, César, Perander, Silva, Pitman, Michael Mark, Prasad, Rajib, Pyrkosz-Pacyna, Joanna, Rathje, Steve, Raza, Ali, Rêgo, Gabriel G., Rhee, Kasey, Robertson, Claire E., Rodríguez-Pascual, Iván, Saikkonen, Teemu, Salvador-Ginez, Octavio, Sampaio, Waldir M., Santi, Gaia C., Santiago-Tovar, Natalia, Savage, David, Scheffer, Julian A., Schönegger, Philipp, Schultner, David T., Schutte, Enid M., Scott, Andy, Sharma, Madhavi, Sharma, Pujan, Skali, Ahmed, Stadelmann, David, Stafford, Clara Alexandra, Stanojević, Dragan, Stefaniak, Anna, Sternisko, Anni, Stoica, Augustin, Stoyanova, Kristina K., Strickland, Brent, Sundvall, Jukka, Thomas, Jeffrey P., Tinghög, Gustav, Torgler, Benno, Traast, Iris J., Tucciarelli, Raffaele, Tyrala, Michael, Ungson, Nick D., Uysal, Mete S., Van Lange, Paul A. M., van Prooijen, Jan-Willem, van Rooy, Dirk, Västfjäll, Daniel, Verkoeijen, Peter, Vieira, Joana B., von Sikorski, Christian, Walker, Alexander Cameron, Watermeyer, Jennifer, Wetter, Erik, Whillans, Ashley, Willardt, Robin, Wohl, Michael J. A., Wójcik, Adrian Dominik, Wu, Kaidi, Yamada, Yuki, Yilmaz, Onurcan, Yogeeswaran, Kumar, Ziemer, Carolin-Theresa, Zwaan, Rolf A., Boggio, Paulo S., Department of Digital Humanities, Faculty Common Matters (Faculty of Arts), Cognitive Science, Helsinki Research Hub on Religion, Media and Social Change, Helsinki Social Computing Group, Doctoral Programme in Cognition, Learning, Instruction and Communication, Mind and Matter, High Performance Cognition group, Medicum, Digital Humanities, Law and Economics, Pharmacy, Public Administration, Molecular Genetics, Research Methods and Techniques, Brain and Cognition, Van Bavel, Jay J [0000-0002-2520-0442], Cichocka, Aleksandra [0000-0003-1703-1586], Sjåstad, Hallgeir [0000-0002-8730-1038], Nezlek, John B [0000-0003-4963-3637], Pavlović, Tomislav [0000-0002-4470-3715], Alfano, Mark [0000-0001-5879-8033], Azevedo, Flavio [0000-0001-9000-8513], Cislak, Aleksandra [0000-0002-9880-6947], Lockwood, Patricia L [0000-0001-7195-9559], Ross, Robert Malcolm [0000-0001-8711-1675], Abts, Koen [0000-0001-8546-8347], Agadullina, Elena [0000-0002-1505-1412], Aruta, John Jamir Benzon [0000-0003-4155-1063], Besharati, Sahba Nomvula [0000-0003-2836-7982], Bor, Alexander [0000-0002-2624-9221], Crabtree, Charles David [0000-0001-5144-8671], De, Koustav [0000-0001-9562-0672], Ejaz, Waqas [0000-0002-2492-4115], Elbaek, Christian T [0000-0002-7039-4565], Findor, Andrej [0000-0002-5896-6989], Franc, Renata [0000-0002-1909-2393], Gjoneska, Biljana [0000-0003-1200-6672], Huynh, Toan Luu Duc [0000-0002-1486-127X], Ibanez, Augustin [0000-0001-6758-5101], Imran, Mostak Ahamed [0000-0002-5101-3149], Kantorowicz, Jaroslaw [0000-0002-1186-5427], Krouwel, André [0000-0003-0952-6028], Laakasuo, Michael [0000-0003-2826-6073], Lamm, Claus [0000-0002-5422-0653], Leygue, Caroline [0000-0002-0355-1030], Lin, Ming-Jen [0000-0002-7174-2226], Mansoor, Mohammad Sabbir [0000-0002-6541-3506], Marie, Antoine [0000-0002-7958-0153], McHugh, Cillian [0000-0002-9701-3232], Minda, John Paul [0000-0002-4081-010X], Mitkidis, Panagiotis [0000-0002-9495-7369], Olsson, Andreas [0000-0001-5272-7744], Otterbring, Tobias [0000-0002-0283-8777], Perry, Anat [0000-0003-2329-856X], Petersen, Michael Bang [0000-0002-6782-5635], Riaño-Moreno, Julián C [0000-0003-4182-0550], Rothmund, Tobias [0000-0003-2979-5129], Schmid, Petra C [0000-0002-9990-5445], Stoyanov, Drozdstoy [0000-0002-9975-3680], Todosijević, Bojan [0000-0002-6116-993X], Tsakiris, Manos [0000-0001-7753-7576], Tung, Hans H [0000-0001-5332-7582], Vanags, Edmunds [0000-0003-1932-936X], Vlasceanu, Madalina [0000-0003-2138-1968], Yucel, Meltem [0000-0002-7274-5971], Zhang, Yucheng [0000-0001-9435-6734], Abad, Mohcine [0000-0002-4964-5411], Mdarhri, Hamza Alaoui [0000-0001-9831-6561], Amara, Hanane [0000-0003-0732-2320], Antazo, Benedict G [0000-0001-9993-8960], Apps, Matthew [0000-0001-5793-2202], Barbosa, Sergio [0000-0003-1989-158X], Bastian, Brock [0000-0003-4619-3322], Bernal-Zárate, Maria P [0000-0001-8232-6220], Białek, Michał [0000-0002-5062-5733], Boncinelli, Leonardo [0000-0003-0626-5133], Booth, Jonathan E [0000-0002-8563-4613], Borau, Sylvie [0000-0003-1564-0695], Buchel, Ondrej [0000-0002-0139-5513], Chalise, Hom Nath [0000-0002-9301-6890], Cian, Luca [0000-0002-8051-1366], Cockcroft, Kate [0000-0002-6166-8050], Conway, Jane [0000-0003-3883-349X], Córdoba-Delgado, Mateo Andres [0000-0002-2264-7388], Crouzevialle, Marie [0000-0002-5538-6030], Cutler, Jo [0000-0003-1073-764X], Dabrowska, Justyna [0000-0002-8821-7161], Davis, Victoria H [0000-0002-7207-4629], Dayley, Pamala N [0000-0001-8955-9502], Delouvee, Sylvain [0000-0002-4029-597X], Di Paolo, Roberto [0000-0002-6081-6656], Dulleck, Uwe [0000-0002-0953-5963], Ekmanis, Jānis [0000-0003-1781-1785], Etienne, Tom W [0000-0002-4299-6593], Farkhari, Fahima [0000-0002-8484-5128], Farmer, Harry [0000-0002-3684-0605], Fenwick, Ali [0000-0002-5412-9745], Flew, Terry [0000-0003-4485-9338], Frempong, Raymond Boadi [0000-0002-4603-5570], Gale, Jessica [0000-0001-5677-8629], Garcia-Navarro, E Begoña [0000-0001-6913-8882], Ghajjou, Oussama [0000-0002-2975-0265], Griffin, Siobhán M [0000-0002-3613-2844], Halperin, Eran [0000-0002-3379-2935], Herzon, Volo [0000-0001-7781-1651], Huang, Guanxiong [0000-0002-8588-1454], Hudecek, Matthias FC [0000-0002-7696-766X], Isler, Ozan [0000-0002-4638-2230], Jangard, Simon [0000-0002-7876-4161], Jørgensen, Frederik J [0000-0002-5461-912X], Kahn, John [0000-0002-0548-3123], Koppel, Lina [0000-0002-6302-0047], Koverola, Mika [0000-0001-8227-6120], Leota, Josh [0000-0002-7714-4630], Lermer, Eva [0000-0002-6600-9580], Maglić, Marina [0000-0002-6851-4601], Metcalf, Alexander L [0000-0001-9532-585X], Miura, Asako [0000-0002-7563-7503], Monroy-Fonseca, César [0000-0003-4696-8159], Morales-Marente, Elena [0000-0002-1227-9606], Moreau, David [0000-0002-1957-1941], Nesh-Nash, Tarik [0000-0002-5532-9095], Nitschke, Jonas P [0000-0002-3244-8585], Nurse, Matthew S [0000-0003-1787-5914], Palomäki, Jussi [0000-0001-6063-0926], Pan, Yafeng [0000-0002-5633-8313], Pavlović, Zoran [0000-0002-9231-5100], Payán-Gómez, César [0000-0002-0633-1332], Perander, Silva [0000-0001-6711-8079], Pitman, Michael Mark [0000-0001-5532-5388], Pyrkosz-Pacyna, Joanna [0000-0002-9112-8629], Raza, Ali [0000-0002-2438-6054], Rhee, Kasey [0000-0002-8562-0801], Rodríguez-Pascual, Iván [0000-0002-5385-3643], Saikkonen, Teemu [0000-0001-9619-3270], Sampaio, Waldir M [0000-0002-6066-4314], Schönegger, Philipp [0000-0001-9930-487X], Schultner, David T [0000-0003-2253-4065], Scott, Andy [0000-0002-3294-0078], Skali, Ahmed [0000-0002-4753-3280], Stadelmann, David [0000-0002-1211-9936], Stafford, Clara Alexandra [0000-0003-1716-7870], Stanojević, Dragan [0000-0002-3667-2461], Stefaniak, Anna [0000-0002-1706-7784], Sternisko, Anni [0000-0002-2507-3076], Stoica, Augustin [0000-0003-0585-1114], Sundvall, Jukka [0000-0003-4310-1162], Tinghög, Gustav [0000-0002-8159-1249], Torgler, Benno [0000-0002-9809-963X], Tucciarelli, Raffaele [0000-0002-0342-308X], Tyrala, Michael [0000-0001-5268-8319], Van Lange, Paul AM [0000-0001-7774-6984], van Prooijen, Jan-Willem [0000-0001-6236-0819], Västfjäll, Daniel [0000-0003-2873-4500], von Sikorski, Christian [0000-0002-3787-8277], Walker, Alexander Cameron [0000-0003-1431-6770], Watermeyer, Jennifer [0000-0001-7918-8832], Whillans, Ashley [0000-0002-1726-6978], Willardt, Robin [0000-0002-2495-3450], Wohl, Michael JA [0000-0001-6945-5562], Wójcik, Adrian Dominik [0000-0002-7073-6019], Wu, Kaidi [0000-0001-6881-7437], Yamada, Yuki [0000-0003-1431-568X], Yilmaz, Onurcan [0000-0002-6094-7162], Ziemer, Carolin-Theresa [0000-0002-0794-7702], Apollo - University of Cambridge Repository, Communication Science, Network Institute, Communication Choices, Content and Consequences (CCCC), Social Psychology, IBBA, A-LAB, New York University [New York] (NYU), NYU System (NYU), University of Kent [Canterbury], Middlesex University [London], Norwegian School of Economics and Business Administration, SWPS University of Social Sciences and Humanities (SWPS), College of William and Mary [Williamsburg] (WM), Ivo Pilar Institute of Social Sciences, Macquarie University, Stanford University, Friedrich-Schiller-Universität = Friedrich Schiller University Jena [Jena, Germany], University of Greenwich, University of Oxford, University of Birmingham [Birmingham], Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Vysšaja škola èkonomiki = National Research University Higher School of Economics [Moscow] (HSE), De La Salle University [Manila] (DLSU), University of the Witwatersrand [Johannesburg] (WITS), Aarhus University [Aarhus], University of Toronto, Dartmouth College [Hanover], University of Kentucky (UK), National University of Sciences and Technology [Islamabad] (NUST), Comenius University in Bratislava, IntraMed, Buenos Aires, DF, Argentina, Macedonian Academy of Sciences and Arts [Skopje, North Macedonia] (MASA), University of Colorado [Boulder], Universidad de Huelva, WHU-Otto Beisheim School of Management, University Adolfo Ibanez (Santiago), University of Dhaka, The Hebrew University of Jerusalem (HUJ), Uniwersytet Jagielloński w Krakowie = Jagiellonian University (UJ), Universiteit Leiden, Erasmus University Rotterdam, Vrije Universiteit Amsterdam [Amsterdam] (VU), Helsingin yliopisto = Helsingfors universitet = University of Helsinki, University of Vienna [Vienna], Universidad Nacional Autónoma de México = National Autonomous University of Mexico (UNAM), National Taiwan University [Taiwan] (NTU), Tribhuvan University, BI Norwegian Business School [Oslo], University of Limerick (UL), University of Western Ontario (UWO), Duke University [Durham], Karolinska Institute, University of Agder (UIA), Lehigh University [Bethlehem], Monk Prayogshala, Cooperative University of Colombia, Pontificia Universidad Javeriana (PUJ), Department of Management, Technology, and Economics [ETH Zürich] (D-MTEC), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Medical University of Plovdiv, Indian Institute of Management Indore (IMM Indore), Institute of Social Sciences Belgrade, University of London [London], University of Luxembourg [Luxembourg], National School of Political and Administrative Studies (SNSPA), University of Latvia (LU), Princeton University, University of Canterbury [Christchurch], University of Virginia, Hebei University of Technology [Tianjin], Université Mohammed VI Polytechnique [Ben Guerir] (UM6P), Institute for Research and Development-Kurdistan, University of Amsterdam [Amsterdam] (UvA), Jose Rizal Memorial State University, Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD), Universidad del Rosario [Bogota], University of Melbourne, Penn State Abington, Pennsylvania Commonwealth System of Higher Education (PCSHE)-Penn State System, University of Wrocław [Poland] (UWr), IMT Alti Studi Lucca, Università degli Studi di Firenze = University of Florence (UniFI), London School of Economics and Political Science (LSE), Toulouse School of Economics (TSE-R), Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT)-Université de Toulouse (UT)-École des hautes études en sciences sociales (EHESS)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Tilburg University [Tilburg], Netspar, Pennsylvania State University (Penn State), Penn State System, Universidade Federal de Santa Catarina = Federal University of Santa Catarina [Florianópolis] (UFSC), University of Bologna/Università di Bologna, Istituto Universitario di Studi Superiori (IUSS), Shenzhen University [Shenzhen], Institute for Advanced Study in Toulouse (IAST), Università degli Studi di Pavia = University of Pavia (UNIPV), Cracow University of Economics, University of British Columbia (UBC), University of California [Los Angeles] (UCLA), University of California (UC), Laboratoire de Psychologie : Cognition, Comportement, Communication (LP3C - EA1285), Université de Bretagne Sud (UBS)-Université de Brest (UBO)-Université de Rennes 2 (UR2)-Institut Brestois des Sciences de l'Homme et de la Société (IBSHS), Université de Brest (UBO), Laboratoire de Psychologie Sociale et Cognitive (LAPSCO), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), University of British Columbia [Vancouver], Cavite State University-General Trias City Campus, School for Advanced Studies Lucca (IMT), Queensland University of Technology [Brisbane] (QUT), Australian National University (ANU), Boǧaziçi üniversitesi = Boğaziçi University [Istanbul], Kieskompas, Hult International Business School Dubai, The University of Sydney, University of Bayreuth, University of Waterloo [Waterloo], University of Bradford, University of Crete [Heraklion] (UOC), University of North Carolina [Chapel Hill] (UNC), University of North Carolina System (UNC), Koç University, City University of Hong Kong [Hong Kong] (CUHK), University of Regensburg, Universität Duisburg-Essen = University of Duisburg-Essen [Essen], Free University of Berlin (FU), Linköping University (LIU), University of Koblenz-Landau, University of Alberta, Ludwig Maximilian University [Munich] (LMU), Interdisciplinary Center Herzliya (IDC), Aalto University, Macquarie University [Sydney], Boston University [Boston] (BU), Dublin City University [Dublin] (DCU), University of Montana, Osaka University [Osaka], SEELE Neuroscience, University of Auckland [Auckland], Maria Curie-Sklodowska University (UMCS), CUNY Graduate Center (The Graduate Center), City University of New York [New York] (CUNY), The University of Tokyo (UTokyo), Mohammed VI Polytechnic University, Hungarian Academy of Sciences (MTA), Medical University of Silesia (SUM), University of Belgrade [Belgrade], Vidyasagar College For Women, AGH University of Science and Technology [Krakow, PL] (AGH UST), University of Cambridge [UK] (CAM), Mackenzie Presbyterian University [São Paulo] (UPM), University of Turku, University of Newcastle [Callaghan, Australia] (UoN), University of St Andrews [Scotland], University of Groningen [Groningen], Carleton University, National University of Political Studies and Public Administration Bucharest, Romania (SNSPA), University of Plovdiv, Institut Jean-Nicod (IJN), Département d'Etudes Cognitives - ENS Paris (DEC), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École des hautes études en sciences sociales (EHESS)-Collège de France (CdF (institution))-Centre National de la Recherche Scientifique (CNRS)-Département de Philosophie - ENS Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Center for Research in Economics, Management and the Arts (CREMA), Partenaires INRAE, University College of London [London] (UCL), The Hong Kong University of Science and Technology, Susquehanna University, Dokuz Eylül Üniversitesi = Dokuz Eylül University [Izmir] (DEÜ), Stockholm School of Economics (SSE), Harvard Business School, Harvard University, Nicolaus Copernicus University [Toruń], University of California [San Diego] (UC San Diego), Kyushu University, Kadir Has University (KHAS), Van Bavel, Jay J. [0000-0002-2520-0442], Nezlek, John B. [0000-0003-4963-3637], Lockwood, Patricia L. [0000-0001-7195-9559], Elbaek, Christian T. [0000-0002-7039-4565], Ibanez, Agustin [0000-0001-6758-5101], Riaño-Moreno, Julián C. [0000-0003-4182-0550], Schmid, Petra C. [0000-0002-9990-5445], Tung, Hans H. [0000-0001-5332-7582], Antazo, Benedict G. [0000-0001-9993-8960], Bernal-Zárate, Maria P. [0000-0001-8232-6220], Booth, Jonathan E. [0000-0002-8563-4613], Davis, Victoria H. [0000-0002-7207-4629], Dayley, Pamala N. [0000-0001-8955-9502], Etienne, Tom W. [0000-0002-4299-6593], Garcia-Navarro, E. Begoña [0000-0001-6913-8882], Griffin, Siobhán M. [0000-0002-3613-2844], Hudecek, Matthias F. C. [0000-0002-7696-766X], Jørgensen, Frederik J. [0000-0002-5461-912X], Metcalf, Alexander L. [0000-0001-9532-585X], Nitschke, Jonas P. [0000-0002-3244-8585], Nurse, Matthew S. [0000-0003-1787-5914], Sampaio, Waldir M. [0000-0002-6066-4314], Schultner, David T. [0000-0003-2253-4065], Stoica, Agustin [0000-0003-0585-1114], Van Lange, Paul A. M. [0000-0001-7774-6984], Wohl, Michael J. A. [0000-0001-6945-5562], New York University, University of Kent, Middlesex University, Norwegian School of Economics, College of William and Mary, Institute of Social Sciences Ivo Pilar, Friedrich Schiller University Jena, SWPS University of Social Sciences and Humanities, KU Leuven, Higher School of Economics, De La Salle University Manila, University of the Witwatersrand, Aarhus University, X University, Dartmouth College, University of Kentucky, National University of Sciences and Technology Pakistan, IntraMed, Macedonian Academy of Sciences and Arts, University of Colorado Boulder, University of Huelva, Otto Beisheim School of Management, Universidad Adolfo Ibáñez, Hebrew University of Jerusalem, Jagiellonian University in Kraków, Leiden University, Vrije Universiteit Amsterdam, University of Helsinki, University of Vienna, Universidad Nacional Autónoma de México, National Taiwan University, BI Norwegian Business School, University of Limerick, Western University, Karolinska Institutet, University of Agder, Lehigh University, Universidad Cooperativa de Colombia, Universidad Javeriana, Swiss Federal Institute of Technology Zurich, Indian Institute of Management Indore, Institute of Social Sciences, Royal Holloway University of London, University of Latvia, University of Canterbury, Duke University, Hebei University of Technology, University of Kurdistan, Impact For Development, Jose Rizal University, University of Birmingham, Université Cheikh Anta Diop de Dakar, Universidad del Rosario, Pennsylvania State University, University of Wrocław, IMT Institute for Advanced Studies Lucca, University of Florence, Birkbeck University of London, Toulouse Business School, Tilburg University, Universidade Federal de Santa Catarina, Universita di Bologna, University of Pavia, Shenzhen University, Université Toulouse 1 Capitole, IRCCS Fondazione Istituto Neurologico Casimiro Mondino - Pavia, University of British Columbia, University of California Los Angeles, University of Rennes 2, University of Amsterdam, Université Clermont Auvergne, Cavite State University, Queensland University of Technology, Bogazici University, University of Sydney, University of Waterloo, University of North Carolina at Chapel Hill, Koc University, City University of Hong Kong, Free University of Berlin, Linköping University, Ludwig Maximilian University of Munich, Department of Neuroscience and Biomedical Engineering, Boston University, Dublin City University, Osaka University, University of Auckland, Maria Curie-Sklodowska University, Australian National University, The University of Tokyo, Hungarian Academy of Sciences, University of Silesia in Katowice, University of Belgrade, University of Calcutta, AGH University of Science and Technology, University of Cambridge, Universidade Presbiteriana Mackenzie, University of Newcastle, University of St Andrews, University of Groningen, National School of Political and Administrative Studies, University College London, Hong Kong University of Science and Technology, Dokuz Eylul University, Stockholm School of Economics, Nicolaus Copernicus University in Toruń, University of California San Diego, Kadir Has University, Aalto-yliopisto, University of St Andrews. School of International Relations, University of St Andrews. School of Psychology and Neuroscience, Van Bavel, J, Cichocka, A, Capraro, V, Sjastad, H, Nezlek, J, Pavlovic, T, Alfano, M, Gelfand, M, Azevedo, F, Birtel, M, Cislak, A, Lockwood, P, Ross, R, Abts, K, Agadullina, E, Aruta, J, Besharati, S, Bor, A, Choma, B, Crabtree, C, Cunningham, W, De, K, Ejaz, W, Elbaek, C, Findor, A, Flichtentrei, D, Franc, R, Gjoneska, B, Gruber, J, Gualda, E, Horiuchi, Y, Huynh, T, Ibanez, A, Imran, M, Israelashvili, J, Jasko, K, Kantorowicz, J, Kantorowicz-Reznichenko, E, Krouwel, A, Laakasuo, M, Lamm, C, Leygue, C, Lin, M, Mansoor, M, Marie, A, Mayiwar, L, Mazepus, H, Mchugh, C, Minda, J, Mitkidis, P, Olsson, A, Otterbring, T, Packer, D, Perry, A, Petersen, M, Puthillam, A, Riano-Moreno, J, Rothmund, T, Santamaria-Garcia, H, Schmid, P, Stoyanov, D, Tewari, S, Todosijevic, B, Tsakiris, M, Tung, H, Umbres, R, Vanags, E, Vlasceanu, M, Vonasch, A, Yucel, M, Zhang, Y, Abad, M, Adler, E, Akrawi, N, Mdarhri, H, Amara, H, Amodio, D, Antazo, B, Apps, M, Ay, F, Ba, M, Barbosa, S, Bastian, B, Berg, A, Bernal-Zarate, M, Bernstein, M, Bialek, M, Bilancini, E, Bogatyreva, N, Boncinelli, L, Booth, J, Borau, S, Buchel, O, Cameron, C, Carvalho, C, Celadin, T, Cerami, C, Chalise, H, Cheng, X, Cian, L, Cockcroft, K, Conway, J, Cordoba-Delgado, M, Crespi, C, Crouzevialle, M, Cutler, J, Cypryanska, M, Dabrowska, J, Daniels, M, Davis, V, Dayley, P, Delouvee, S, Denkovski, O, Dezecache, G, Dhaliwal, N, Diato, A, Di Paolo, R, Drosinou, M, Dulleck, U, Ekmanis, J, Ertan, A, Etienne, T, Farhana, H, Farkhari, F, Farmer, H, Fenwick, A, Fidanovski, K, Flew, T, Fraser, S, Frempong, R, Fugelsang, J, Gale, J, Garcia-Navarro, E, Garladinne, P, Ghajjou, O, Gkinopoulos, T, Gray, K, Griffin, S, Gronfeldt, B, Gumren, M, Gurung, R, Halperin, E, Harris, E, Herzon, V, Hruska, M, Huang, G, Hudecek, M, Isler, O, Jangard, S, Jorgensen, F, Kachanoff, F, Kahn, J, Dangol, A, Keudel, O, Koppel, L, Koverola, M, Kubin, E, Kunnari, A, Kutiyski, Y, Laguna, O, Leota, J, Lermer, E, Levy, J, Levy, N, Li, C, Long, E, Longoni, C, Maglic, M, Mccashin, D, Metcalf, A, Miklousic, I, El Mimouni, S, Miura, A, Molina-Paredes, J, Monroy-Fonseca, C, Morales-Marente, E, Moreau, D, Muda, R, Myer, A, Nash, K, Nesh-Nash, T, Nitschke, J, Nurse, M, Ohtsubo, Y, Oldemburgo de Mello, V, O'Madagain, C, Onderco, M, Palacios-Galvez, M, Palomaki, J, Pan, Y, Papp, Z, Parnamets, P, Paruzel-Czachura, M, Pavlovic, Z, Payan-Gomez, C, Perander, S, Pitman, M, Prasad, R, Pyrkosz-Pacyna, J, Rathje, S, Raza, A, Rego, G, Rhee, K, Robertson, C, Rodriguez-Pascual, I, Saikkonen, T, Salvador-Ginez, O, Sampaio, W, Santi, G, Santiago-Tovar, N, Savage, D, Scheffer, J, Schonegger, P, Schultner, D, Schutte, E, Scott, A, Sharma, M, Sharma, P, Skali, A, Stadelmann, D, Stafford, C, Stanojevic, D, Stefaniak, A, Sternisko, A, Stoica, A, Stoyanova, K, Strickland, B, Sundvall, J, Thomas, J, Tinghog, G, Torgler, B, Traast, I, Tucciarelli, R, Tyrala, M, Ungson, N, Uysal, M, Van Lange, P, van Prooijen, J, van Rooy, D, Vastfjall, D, Verkoeijen, P, Vieira, J, von Sikorski, C, Walker, A, Watermeyer, J, Wetter, E, Whillans, A, Willardt, R, Wohl, M, Wojcik, A, Wu, K, Yamada, Y, Yilmaz, O, Yogeeswaran, K, Ziemer, C, Zwaan, R, and Boggio, P
Subjects: IMAGE, Health Behavior, COVID-19, national identity, public health, pandemic, cross-cultural, Collective narcissism, Settore SECS-P/02 - Politica Economica, health behavior, Sociology, RA0421 Public health. Hygiene. Preventive Medicine, Settore SECS-P/01 - Economia Politica, public health behaviours, COVID-19, collective behaviour, Public health, [SHS.SOCIO]Humanities and Social Sciences/Sociology, Social Identification, 706/689/477/2811, article, Social identity, Public Health, Global Health, Social Medicine and Epidemiology, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, 3142 Public health care science, environmental and occupational health, VDP::Medisinske Fag: 700::Helsefag: 800, 5141 Sociology, Settore SECS-P/03 - Scienza delle Finanze, National identity, Human, Cross-Cultural Comparison, BF Psychology, Science, COVID-19 pandemic, BF, national narcissism, HV Social pathology. Social and public welfare. Criminology, Humans, Leadership, Pandemics, Public Health, SARS-CoV-2, Self Report, Social Conformity, Human development, 692/699/255/2514, SDG 3 - Good Health and Well-being, Human behaviour, political ideology, COLLECTIVE NARCISSISM, SOCIAL IDENTITY, MCC, Pandemic, IDENTIFICATION, DAS, [SHS.SCIPO]Humanities and Social Sciences/Political science, Coronavirus, MODEL, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, Viral infection, Idenfication, Image, RA Public aspects of medicine, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Human medicine, RA, Model
Abstract: Funder: Research Council of Norway through its Centres of Excellence Scheme, FAIR project No 262675, Funder: J. William Fulbright Program, Funder: Institute for Lifecourse Development, University of Greenwich, Funder: Economic Social Research Council Impact Acceleration Award, University of Oxford, Funder: Institute of Social Sciences Ivo Pilar, Funder: Academy of Finland (Suomen Akatemia); doi: https://doi.org/10.13039/501100002341, Funder: Universität Wien (University of Vienna); doi: https://doi.org/10.13039/501100003065, Funder: Ministry of Science and Technology, Taiwan (Ministry of Science and Technology of Taiwan); doi: https://doi.org/10.13039/501100004663, Funder: NOMIS Stiftung (NOMIS Foundation); doi: https://doi.org/10.13039/501100008483, Funder: Princeton Graduate Student Research Funding (Program in Cognitive Science), Funder: Corruption Laboratory on Ethics, Accountability, and the Rule of Law (CLEAR), University of Virginia, Funder: Project Pro.Co.P.E., IMT School (PAI2019), Funder: Italian Ministry of University and Research - PRIN 2017 (20178293XT), Funder: Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada (Conseil de Recherches en Sciences Naturelles et en Génie du Canada); doi: https://doi.org/10.13039/501100000038, Funder: Australian Research Council (DP180102384), Funder: Ernst and Young (EY); doi: https://doi.org/10.13039/501100003064, Changing collective behaviour and supporting non-pharmaceutical interventions is an important component in mitigating virus transmission during a pandemic. In a large international collaboration (Study 1, N = 49,968 across 67 countries), we investigated self-reported factors associated with public health behaviours (e.g., spatial distancing and stricter hygiene) and endorsed public policy interventions (e.g., closing bars and restaurants) during the early stage of the COVID-19 pandemic (April-May 2020). Respondents who reported identifying more strongly with their nation consistently reported greater engagement in public health behaviours and support for public health policies. Results were similar for representative and non-representative national samples. Study 2 (N = 42 countries) conceptually replicated the central finding using aggregate indices of national identity (obtained using the World Values Survey) and a measure of actual behaviour change during the pandemic (obtained from Google mobility reports). Higher levels of national identification prior to the pandemic predicted lower mobility during the early stage of the pandemic (r = −0.40). We discuss the potential implications of links between national identity, leadership, and public health for managing COVID-19 and future pandemics.
Published: 2022

19. Alzheimer's disease research progress in Australia: The Alzheimer's Association International Conference Satellite Symposium in Sydney

Author: Henry Brodaty, Anna M. Barron, Rachel A. Whitmer, Jürgen Götz, Akinori Nakamura, Simon M. Laws, Colin L. Masters, Kate Smith, Darren M. Lipnicki, Filippo Baldacci, Lisa J. Bain, Wendy Moyle, Cassandra Szoeke, Claire Sexton, Maria C. Carrillo, Christopher J. Barnum, Einar M. Sigurdsson, Peter R. Schofield, Fanny M. Elahi, Nicola T. Lautenschlager, Samantha C. Burnham, Susan M. Landau, Hanzhang Lu, Malú G. Tansey, Maya Koronyo-Hamaoui, Velandai Srikanth, Donna M. Wilcock, Kaj Blennow, Yun-Hee Jeon, Perminder S. Sachdev, Christopher C. Rowe, Kaarin J. Anstey, Naren P. Rao, Giulio Maria Pasinetti, Tien Yin Wong, Alzheimer's Association, University of New South Wales [Sydney] (UNSW), University of Pisa - Università di Pisa, INmune Bio, Lee Kong Chian School of Medicine, Nanyang Technological University (NTU), University of Gothenburg (GU), The Australian e-Health Research centre, Royal Brisbane and Women's Hospital, Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), The University of Sydney, Cedars-Sinai Medical Center, University of California [Berkeley], University of California, Department of Psychiatry and National Ageing Research Institute, University of Melbourne, Edith Cowan University (ECU), Commonwealth Scientific and Industrial Research Organisation [Canberra] (CSIRO)-Planning and Transport Research Centre (PATREC), Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney, Johns Hopkins University School of Medicine [Baltimore], The Florey Institute of Neuroscience and Mental Health, Menzies Health Institute Queensland, Griffith University Brisbane, National Center for Geriatrics and Gerontology, Research Institute, Icahn School of Medicine at Mount Sinai [New York] (MSSM), National Institute of Mental Health and Neurosciences [Bagalore, India], Neuroscience Research Australia (NeuRA), New York University School of Medicine (NYU Grossman School of Medicine), The University of Western Australia (UWA), Peninsula Clinical School, The University of Florida College of Medicine, University of California [Davis] (UC Davis), University of Kentucky, Singapore Eye Research Institute [Singapore] (SERI), Chercheur indépendant, Gestionnaire, HAL Sorbonne Université 5, Nanyang Technological University [Singapour], Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), University of California [Berkeley] (UC Berkeley), University of California (UC), and University of Kentucky (UK)
Subjects: 0301 basic medicine, Gerontology, Aging, Biomedical Research, Epidemiology, behavioral symptoms, Disease, Neurodegenerative, Alzheimer's Disease, Alzheimer&apos, 0302 clinical medicine, Global studies, prevention, Cognitive impairment, health care economics and organizations, Health Policy, Alzheimer's, 3. Good health, Psychiatry and Mental health, Neurological, Disease Progression, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Psychology, biomarkers, dementia, education, Clinical Sciences, Prodromal Symptoms, Alzheimer's disease research, 03 medical and health sciences, Cellular and Molecular Neuroscience, Developmental Neuroscience, Alzheimer Disease, Lifestyle intervention, Behavioral and Social Science, medicine, Acquired Cognitive Impairment, Dementia, Humans, Cognitive Dysfunction, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Healthy aging, Life Style, Australia, Neurosciences, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), medicine.disease, Brain Disorders, 030104 developmental biology, Increased risk, Geriatrics, Positron-Emission Tomography, Neurology (clinical), Geriatrics and Gerontology, 030217 neurology & neurosurgery
Abstract: International audience; The Alzheimer's Association International Conference held its sixth Satellite Symposium in Sydney, Australia in 2019, highlighting the leadership of Australian researchers in advancing the understanding of and treatment developments for Alzheimer's disease (AD) and other dementias.This leadership includes the Australian Imaging, Biomarker, and Lifestyle Flagship Study of Ageing (AIBL), which has fueled the identification and development of many biomarkers and novel therapeutics. Two multimodal lifestyle intervention studies have been launched in Australia; and Australian researchers have played leadership roles in other global studies in diverse populations.Australian researchers have also played an instrumental role in efforts to understand mechanisms underlying vascular contributions to cognitive impairment and dementia; and through the Women's Healthy Aging Project have elucidated hormonal and other factors that contribute to the increased risk of AD in women. Alleviating the behavioral and psychological symptoms of dementia has also been a strong research and clinical focus in Australia.
Published: 2022

20. SEMA6B variants cause intellectual disability and alter dendritic spine density and axon guidance

Author: Amélie Cordovado, Martina Schaettin, Médéric Jeanne, Veranika Panasenkava, Anne-Sophie Denommé-Pichon, Boris Keren, Cyril Mignot, Martine Doco-Fenzy, Lance Rodan, Keri Ramsey, Vinodh Narayanan, Julie R Jones, Eloise J Prijoles, Wendy G Mitchell, Jillian R Ozmore, Kali Juliette, Erin Torti, Elizabeth A Normand, Leslie Granger, Andrea K Petersen, Margaret G Au, Juliann P Matheny, Chanika Phornphutkul, Mary-Kathryn Chambers, Joaquín-Alejandro Fernández-Ramos, Eduardo López-Laso, Michael C Kruer, Somayeh Bakhtiari, Marcella Zollino, Manuela Morleo, Giuseppe Marangi, Davide Mei, Tiziana Pisano, Renzo Guerrini, Raymond J Louie, Anna Childers, David B Everman, Betrand Isidor, Séverine Audebert-Bellanger, Sylvie Odent, Dominique Bonneau, Brigitte Gilbert-Dussardier, Richard Redon, Stéphane Bézieau, Frédéric Laumonnier, Esther T Stoeckli, Annick Toutain, Marie-Laure Vuillaume, Jonchère, Laurent, Imagerie et cerveau (iBrain - Inserm U1253 - UNIV Tours ), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Universität Zürich [Zürich] = University of Zurich (UZH), FHU TRANSLAD (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Equipe GAD (LNC - U1231), Lipides - Nutrition - Cancer [Dijon - U1231] (LNC), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Agro Dijon, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Agro Dijon, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Hémostase et Remodelage Vasculaire Post-Ischémie (HERVI - EA 3801), Université de Reims Champagne-Ardenne (URCA), Boston Children's Hospital, Harvard Medical School [Boston] (HMS), The Translational Genomics Research Institute (TGen), The Greenwood Genetic Center, Keck School of Medicine [Los Angeles], University of Southern California (USC), Dartmouth Hitchcock Medical Center [Lebanon], Gillette Children's Specialty Healthcare [St Paul], GeneDx [Gaithersburg, MD, USA], Randall Children's Hospital [Portland], University of Kentucky (UK), Warren Alpert Medical School of Brown University, Rhode Island Hospital [Providence, RI, États-Unis], Instituto Maimonides de Investigación Biomédica de Cordoba (IMIBIC), Universidad de Córdoba = University of Córdoba [Córdoba]-Hospital Universitario Reina Sofía, Barrow Neurological Institute, Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS), Telethon Institute of Genetics and Medicine = Istituto Telethon di Genetica e Medicina (TIGEM), Università degli Studi di Firenze = University of Florence (UniFI), Centre hospitalier universitaire de Nantes (CHU Nantes), Hôpital Morvan - CHRU de Brest (CHU - BREST ), Institut de Génétique et Développement de Rennes (IGDR), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), CHU Pontchaillou [Rennes], MitoVasc - Physiopathologie Cardiovasculaire et Mitochondriale (MITOVASC), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Funding for HUGODIMS (Western France exome-based trio approach project to identifygenes involved in intellectual disability) was supported by a grant from the French Ministryof Health and from the Health Regional Agency from Poitou-Charentes [HUGODIMS, 2013,RC14_0107]. [A.C.] is a research student recipient of a grant from the University of Tours., Cordovado, Amélie, Schaettin, Martina, Jeanne, Médéric, Panasenkava, Veranika, Denommé-Pichon, Anne-Sophie, Keren, Bori, Mignot, Cyril, Doco-Fenzy, Martine, Rodan, Lance, Ramsey, Keri, Narayanan, Vinodh, Jones, Julie R, Prijoles, Eloise J, Mitchell, Wendy G, Ozmore, Jillian R, Juliette, Kali, Torti, Erin, Normand, Elizabeth A, Granger, Leslie, Petersen, Andrea K, Au, Margaret G, Matheny, Juliann P, Phornphutkul, Chanika, Chambers, Mary-Kathryn, Fernández-Ramos, Joaquín-Alejandro, López-Laso, Eduardo, Kruer, Michael C, Bakhtiari, Somayeh, Zollino, Marcella, Morleo, Manuela, Marangi, Giuseppe, Mei, Davide, Pisano, Tiziana, Guerrini, Renzo, Louie, Raymond J, Childers, Anna, Everman, David B, Isidor, Betrand, Audebert-Bellanger, Séverine, Odent, Sylvie, Bonneau, Dominique, Gilbert-Dussardier, Brigitte, Redon, Richard, Bézieau, Stéphane, Laumonnier, Frédéric, Stoeckli, Esther T, Toutain, Annick, and Vuillaume, Marie-Laure
Subjects: [SDV.GEN]Life Sciences [q-bio]/Genetics, Epilepsy, Dendritic Spines, [SDV]Life Sciences [q-bio], Intellectual disability, Chick Embryo, Semaphorins, [SDV.GEN] Life Sciences [q-bio]/Genetics, General Medicine, Settore MED/03 - GENETICA MEDICA, Axon Guidance, [SDV] Life Sciences [q-bio], HEK293 Cells, SEMA6B, Intellectual Disability, Genetics, Animals, Humans, Original Article, Molecular Biology, Genetics (clinical)
Abstract: Intellectual disability (ID) is a neurodevelopmental disorder frequently caused by monogenic defects. In this study, we collected 14 SEMA6B heterozygous variants in 16 unrelated patients referred for ID to different centers. Whereas, until now, SEMA6B variants have mainly been reported in patients with progressive myoclonic epilepsy, our study indicates that the clinical spectrum is wider and also includes non-syndromic ID without epilepsy or myoclonus. To assess the pathogenicity of these variants, selected mutated forms of Sema6b were overexpressed in Human Embryonic Kidney 293T (HEK293T) cells and in primary neuronal cultures. shRNAs targeting Sema6b were also used in neuronal cultures to measure the impact of the decreased Sema6b expression on morphogenesis and synaptogenesis. The overexpression of some variants leads to a subcellular mislocalization of SEMA6B protein in HEK293T cells and to a reduced spine density owing to loss of mature spines in neuronal cultures. Sema6b knockdown also impairs spine density and spine maturation. In addition, we conducted in vivo rescue experiments in chicken embryos with the selected mutated forms of Sema6b expressed in commissural neurons after knockdown of endogenous SEMA6B. We observed that expression of these variants in commissural neurons fails to rescue the normal axon pathway. In conclusion, identification of SEMA6B variants in patients presenting with an overlapping phenotype with ID and functional studies highlight the important role of SEMA6B in neuronal development, notably in spine formation and maturation and in axon guidance. This study adds SEMA6B to the list of ID-related genes.
Published: 2022

21. COPD: Providing the right treatment for the right patient at the right time

Author: Alvar Agusti, Nicolino Ambrosino, Felicity Blackstock, Jean Bourbeau, Richard Casaburi, Bartolome Celli, Gerard J. Criner, Rebecca Crouch, Roberto W. Dal Negro, Michael Dreher, Chris Garvey, Daniel A. Gerardi, Roger Goldstein, Nicola A. Hanania, Anne E. Holland, Antarpreet Kaur, Suzanne Lareau, Peter K. Lindenauer, David Mannino, Barry Make, François Maltais, Jeffrey D. Marciniuk, Paula Meek, Mike Morgan, Jean-Louis Pepin, Jane Z. Reardon, Carolyn L. Rochester, Sally Singh, Martijn A. Spruit, Michael C. Steiner, Thierry Troosters, Michele Vitacca, Enico Clini, Jose Jardim, Linda Nici, Jonathan Raskin, Richard ZuWallack, University of Barcelona, Istituti Clinici Scientifici Maugeri [Pavia] (IRCCS Pavia - ICS Maugeri), La Trobe University [Melbourne], McGill University = Université McGill [Montréal, Canada], UCLA School of Medicine [Torrance, CA, USA], Harvard Medical School [Boston] (HMS), Campbell University [Buies Creek, NC, USA] (CU), CESFAR - Centro Nazionale Studi di Farmacoeconmia, Universitätsklinikum RWTH Aachen - University Hospital Aachen [Aachen, Germany] (UKA), Rheinisch-Westfälische Technische Hochschule Aachen University (RWTH), UCSF Sleep Disorders [San Francisco, CA, USA], Trinity Health of New England [Hartford, CT, USA] (THNE), West Park Health Care Centre [Toronto, ON, Canada] (WPH2C), Baylor College of Medicine (BCM), Baylor University, Monash University [Melbourne], University of Colorado Anschutz [Aurora], University of Massachusetts System (UMASS), University of Kentucky (UK), National Jewish Health (NJH), Institut Universitaire de Cardiologie et de Pneumologie de Québec (IUCPQ), Université Laval [Québec] (ULaval), University of Saskatchewan [Saskatoon] (U of S), University of Utah, University of Leicester, Hypoxie et PhysioPathologie (HP2), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), Yale University [New Haven], CIRO [Horn, The Netherlands], Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE), Federal University of Sao Paulo (Unifesp), Brown University, Mount Sinai School of Medicine, Department of Psychiatry-Icahn School of Medicine at Mount Sinai [New York] (MSSM), Université Saint-Francis-Xavier (CANADA), and SALAS, Danielle
Subjects: [SDV] Life Sciences [q-bio], Pulmonary and Respiratory Medicine, COPD, Pulmonary Rehabilitation, Non-Pharmacologic Treatment, Comprehensive Care of the COPD Patient, [SDV]Life Sciences [q-bio]
Abstract: International audience; Chronic Obstructive Pulmonary Disease (COPD) is a common disease associated with significant morbidity and mortality that is both preventable and treatable. However, a major challenge in recognizing, preventing, and treating COPD is understanding its complexity. While COPD has historically been characterized as a disease defined by airflow limitation, we now understand it as a multi-component disease with many clinical phenotypes, systemic manifestations, and associated co-morbidities. Evidence is rapidly emerging in our understanding of the many factors that contribute to the pathogenesis of COPD and the identification of "early" or "pre-COPD" which should provide exciting opportunities for early treatment and disease modification. In addition to breakthroughs in our understanding of the origins of COPD, we are optimizing treatment strategies and delivery of care that are showing impressive benefits in patient-centered outcomes and healthcare utilization. This special issue of Respiratory Medicine, "COPD: Providing the Right Treatment for the Right Patient at the Right Time" is a summary of the proceedings of a conference held in Stresa, Italy in April 2022 that brought together international experts to discuss emerging evidence in COPD and Pulmonary Rehabilitation in honor of a distinguished friend and colleague, Claudio Ferdinando Donor (1948-2021). Claudio was a true pioneer in the field of pulmonary rehabilitation and the comprehensive care of individuals with COPD. He held numerous leadership roles in in the field, provide editorial stewardship of several respiratory journals, authored numerous papers, statement and guidelines in COPD and Pulmonary Rehabilitation, and provided mentorship to many in our field. Claudio's most impressive talent was his ability to organize spectacular conferences and symposia that highlighted cutting edge science and clinical medicine. It is in this spirit that this conference was conceived and planned. These proceedings are divided into 4 sections which highlight crucial areas in the field of COPD: (1) New concepts in COPD pathogenesis; (2) Enhancing outcomes in COPD; (3) Non-pharmacologic management of COPD; and (4) Optimizing delivery of care for COPD. These presentations summarize the newest evidence in the field and capture lively discussion on the exciting future of treating this prevalent and impactful disease. We thank each of the authors for their participation and applaud their efforts toward pushing the envelope in our understanding of COPD and optimizing care for these patients. We believe that this edition is a most fitting tribute to a dear colleague and friend and will prove useful to students, clinicians, and researchers as they continually strive to provide the right treatment for the right patient at the right time. It has been our pleasure and a distinct honor to serve as editors and oversee such wonderful scholarly work.
Published: 2023

22. Simultaneously minimizing residual stress and enhancing strength of selective laser melted nano-TiB 2 decorated Al alloy via post-uphill quenching and ageing

Author: Zuojia Chen, Huiying Wang, Hongze Wang, Zeyu Bian, Q. Lian, Gang Ji, Yinglin Xiao, Y. J. Wu, Chimie des polymères (LCP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut Parisien de Chimie Moléculaire (IPCM), Institut de Chimie du CNRS (INC)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Jack Baskin School of Engineering (UCSC), University of California [Santa Cruz] (UCSC), University of California-University of California, Institute of Applied Physics and Computational Mathematics - IACM (Beijing, China)), Chinese Academy of Sciences [Beijing] (CAS), Unité Matériaux et Transformations - UMR 8207 (UMET), Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centrale Lille Institut (CLIL), University of Kentucky, University of California [Santa Cruz] (UC Santa Cruz), University of California (UC)-University of California (UC), Centrale Lille-Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and University of Kentucky (UK)
Subjects: Materials science, Alloy, Residual stress, chemistry.chemical_element, Mechanical properties, 02 engineering and technology, engineering.material, 01 natural sciences, [SPI]Engineering Sciences [physics], Aluminium, 0103 physical sciences, Nano, Ultimate tensile strength, General Materials Science, Composite material, Selective laser melting, 010302 applied physics, Quenching, Mechanical Engineering, Aluminium alloys, 021001 nanoscience & nanotechnology, Condensed Matter Physics, chemistry, Mechanics of Materials, engineering, Dislocation, Uphill quenching and ageing, 0210 nano-technology
Abstract: International audience; Selective laser melting (SLM) of aluminium alloys is of research interest to produce customized or complexshaped metal components for functional or structural applications. In order to palliate the undesirable residual stress developed in the SLM process, traditional post-annealing heat treatment has been widely used to lower residual stress in selective laser melted (SLMed) Al alloys. However, the traditional post-annealing method usually leads to a decrease in strength which is another concern for applications. In this study, we developed and validated a new strategy combining post-uphill quenching and subsequent ageing to simultaneously minimise residual stress and increase the strength of SLMed nano-TiB2 decorated Al alloy parts. The results show that the high as-built residual stress was partly counteracted by the newly-produced residual stress in the opposite direction during the uphill quenching stage and synergistically reduced by dislocation recovery during the ageing stage. The microstructural features of grains and cell structures remain unchanged after the treatment. While substantial new nano-Si particles with dot-like or needle-like morphology precipitate inside the cells. The tensile strength was improved mainly due to effective precipitation strengthening by dispersed nanosized Si precipitates. The proposed strategy is expected to be useful in other materials and components fabricated by SLM in which residual stress is also unwanted.
Published: 2021

23. Population genomics of apricots unravels domestication history and adaptive events

Author: Patrick Wincker, Corinne Cruaud, William Marande, Guillaume Roch, Amandine Cornille, Nathalie Rodde, Jean-Marc Aury, Robert Debuchy, Quynh Trang Bui, David Tricon, Pierre Pétriacq, Jérôme Salse, Rémy Félix Serre, Sandrine Arribat, Tatiana Giraud, Alexis Groppi, Erwan Denis, Wassim Rhalloussi, Céline Lopez-Roques, Véronique Decroocq, Olivier Bouchez, Shuo Liu, Macha Nikolski, Jean Marc Audergon, Sébastien Carrère, Xilong Chen, Patrick Lambert, Caroline Belser, Cecile Huneau, Stéphane Decroocq, Tetyana Zhebentyayeva, Stéphane Cauet, Weisheng Liu, Joseph Tran, Benjamin Istace, Albert G. Abbott, Aurélien Barré, Centre de Bioinformatique de Bordeaux (CBIB), CGFB, Institut de biochimie et génétique cellulaires (IBGC), Université Bordeaux Segalen - Bordeaux 2-Centre National de la Recherche Scientifique (CNRS), Biologie du fruit et pathologie (BFP), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Research Institute of Pomology (RIP CAAS), Chinese Academy of Agricultural Sciences (CAAS), Génétique Quantitative et Evolution - Le Moulon (Génétique Végétale) (GQE-Le Moulon), AgroParisTech-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Genoscope - Centre national de séquençage [Evry] (GENOSCOPE), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Génomique métabolique (UMR 8030), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université d'Évry-Val-d'Essonne (UEVE), Centre National de Ressources Génomiques Végétales (CNRGV), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Génétique Diversité et Ecophysiologie des Céréales (GDEC), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), Laboratoire des interactions plantes micro-organismes (LIPM), Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Génétique et Amélioration des Fruits et Légumes (GAFL), CEP Innovation, The Schatz Center for Tree Molecular Genetics,Department of Ecosystem Science and Management, The Pennsylvania State University, Génome et Transcriptome - Plateforme Génomique ( GeT-PlaGe), Plateforme Génome & Transcriptome (GET), Génopole Toulouse Midi-Pyrénées [Auzeville] (GENOTOUL), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Génopole Toulouse Midi-Pyrénées [Auzeville] (GENOTOUL), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Ecophysiologie et Génomique Fonctionnelle de la Vigne (UMR EGFV), Université de Bordeaux (UB)-Institut des Sciences de la Vigne et du Vin (ISVV)-Ecole Nationale Supérieure des Sciences Agronomiques de Bordeaux-Aquitaine (Bordeaux Sciences Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Forest Health Research and Education Center,University of Kentucky, (FHC), Ecologie Systématique et Evolution (ESE), AgroParisTech-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), ANR-11-CHEX-0002,ABRIWG,Génomique comparative et fonctionnelle de la résistance à la sharka et des besoins en froid chez les arbres fruitiers à noyaux(2011), Université de Bordeaux (UB)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Laboratoire des Interactions Plantes Microbes Environnement (LIPME), Pennsylvania State University (Penn State), Penn State System, Liaoning Institute of Pomology, Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), University of Kentucky (UK), GET-PACBIO program (« Programme opérationnel FEDER-FSEMIDI-PYRENEES ET GARONNE 2014-2020 »), ANR-10-INBS-0009,France-Génomique,Organisation et montée en puissance d'une Infrastructure Nationale de Génomique(2010), Gauthier, Muriel, Organisation et montée en puissance d'une Infrastructure Nationale de Génomique - - France-Génomique2010 - ANR-10-INBS-0009 - INBS - VALID, Université Bordeaux Segalen - Bordeaux 2-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Sciences et Technologies - Bordeaux 1, Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Génopole Toulouse Midi-Pyrénées [Auzeville] (GENOTOUL), Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and University of Kentucky
Subjects: 0106 biological sciences, 0301 basic medicine, Prunus armeniaca, [SDV]Life Sciences [q-bio], General Physics and Astronomy, adaptation, 01 natural sciences, Gene flow, Population genomics, Plant evolution, [SDV.BV] Life Sciences [q-bio]/Vegetal Biology, Arbre fruitier à noyau, Génétique, Phylogeny, Disease Resistance, Multidisciplinary, biology, Phylogenomics, [SDV] Life Sciences [q-bio], Génomique, Phenotype, [SDV.BV.AP] Life Sciences [q-bio]/Vegetal Biology/Plant breeding, Gene pool, Fruit à noyau, Genome, Plant, Gene Flow, Agricultural genetics, Abricotier, Science, Chromosomes, Plant, Article, General Biochemistry, Genetics and Molecular Biology, Evolution, Molecular, [SDV.GEN.GPL]Life Sciences [q-bio]/Genetics/Plants genetics, 03 medical and health sciences, domestication, [SDV.BV]Life Sciences [q-bio]/Vegetal Biology, Selection, Genetic, Domestication, Abricot, Life Cycle Stages, Genetic diversity, [SDV.GEN]Life Sciences [q-bio]/Genetics, Genetic Variation, General Chemistry, Phenotypic trait, biology.organism_classification, [SDV.BV.AP]Life Sciences [q-bio]/Vegetal Biology/Plant breeding, 030104 developmental biology, Evolutionary biology, Fruit, Metagenomics, Adaptation, divergence, 010606 plant biology & botany
Abstract: Among crop fruit trees, the apricot (Prunus armeniaca) provides an excellent model to study divergence and adaptation processes. Here, we obtain nearly 600 Armeniaca apricot genomes and four high-quality assemblies anchored on genetic maps. Chinese and European apricots form two differentiated gene pools with high genetic diversity, resulting from independent domestication events from distinct wild Central Asian populations, and with subsequent gene flow. A relatively low proportion of the genome is affected by selection. Different genomic regions show footprints of selection in European and Chinese cultivated apricots, despite convergent phenotypic traits, with predicted functions in both groups involved in the perennial life cycle, fruit quality and disease resistance. Selection footprints appear more abundant in European apricots, with a hotspot on chromosome 4, while admixture is more pervasive in Chinese cultivated apricots. Our study provides clues to the biology of selected traits and targets for fruit tree research and breeding., The evolutionary and domestication history of apricots is poorly understood. Here, the authors provide four apricot high-quality genome assemblies, the genomes of 578 accessions from natural and cultivated populations, and show that Chinese and European apricots constitute two different gene pools, resulting from independent domestication events.
Published: 2021

24. Changes in laboratory value improvement and mortality rates over the course of the pandemic: an international retrospective cohort study of hospitalised patients infected with SARS-CoV-2

Author: Hong, Chuan, Zhang, Harrison, L'Yi, Sehi, Weber, Griffin, Avillach, Paul, Tan, Bryce, Gutiérrez-Sacristán, Alba, Bonzel, Clara-Lea, Palmer, Nathan, Malovini, Alberto, Tibollo, Valentina, Luo, Yuan, Hutch, Meghan, Liu, Molei, Bourgeois, Florence, Bellazzi, Riccardo, Chiovato, Luca, Sanz Vidorreta, Fernando, Le, Trang, Wang, Xuan, Yuan, William, Neuraz, Antoine, Benoit, Vincent, Moal, Bertrand, Morris, Michele, Hanauer, David, Maidlow, Sarah, Wagholikar, Kavishwar, Murphy, Shawn, Estiri, Hossein, Makoudjou, Adeline, Tippmann, Patric, Klann, Jeffery, Follett, Robert, Gehlenborg, Nils, Omenn, Gilbert, Xia, Zongqi, Dagliati, Arianna, Visweswaran, Shyam, Patel, Lav, Mowery, Danielle, Schriver, Emily, Samayamuthu, Malarkodi Jebathilagam, Kavuluru, Ramakanth, Lozano-Zahonero, Sara, Zöller, Daniela, Tan, Amelia, Tan, Byorn, Ngiam, Kee Yuan, Holmes, John, Schubert, Petra, Cho, Kelly, Ho, Yuk-Lam, Beaulieu-Jones, Brett, Pedrera-Jiménez, Miguel, García-Barrio, Noelia, Serrano-Balazote, Pablo, Kohane, Isaac, South, Andrew, Brat, Gabriel, Cai, T, Harvard Medical School [Boston] (HMS), Brigham & Women’s Hospital [Boston] (BWH), Columbia University [New York], National University Hospital [Singapore] (NUH), Istituti Clinici Scientifici Maugeri [Pavia] (IRCCS Pavia - ICS Maugeri), Northwestern University [Chicago, Ill. USA], Università degli Studi di Pavia = University of Pavia (UNIPV), Laboratoire Magmas et Volcans (LMV), Institut national des sciences de l'Univers (INSU - CNRS)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut de Recherche pour le Développement et la société-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS)-Observatoire de Physique du Globe de Clermont-Ferrand (OPGC), Institut national des sciences de l'Univers (INSU - CNRS)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), University of Science and Technology of China [Hefei] (USTC), Université Paris Cité (UPCité), Health data- and model- driven Knowledge Acquisition (HeKA), Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), Service d'informatique médicale et biostatistiques [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Northwestern University [Evanston], Harvard T.H. Chan School of Public Health, David Geffen School of Medicine [Los Angeles], University of California [Los Angeles] (UCLA), University of California (UC)-University of California (UC), University of Pennsylvania, École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité)-École Pratique des Hautes Études (EPHE), Université de Bordeaux (UB), University of Pittsburgh (PITT), Pennsylvania Commonwealth System of Higher Education (PCSHE), University of Michigan Medical School [Ann Arbor], University of Michigan [Ann Arbor], University of Michigan System-University of Michigan System, University of Michigan System, Massachusetts General Hospital [Boston], University of Freiburg [Freiburg], University of Kansas [Kansas City], Hospital of the University of Pennsylvania (HUP), Perelman School of Medicine, University of Pennsylvania-University of Pennsylvania, University of Kentucky (UK), VA Boston Healthcare System, Hospital Universitario 12 de Octubre [Madrid], and Wake Forest University
Subjects: Hospitalization, SARS-CoV-2, COVID-19, Humans, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, General Medicine, Pandemics, Retrospective Studies
Abstract: ObjectiveTo assess changes in international mortality rates and laboratory recovery rates during hospitalisation for patients hospitalised with SARS-CoV-2 between the first wave (1 March to 30 June 2020) and the second wave (1 July 2020 to 31 January 2021) of the COVID-19 pandemic.Design, setting and participantsThis is a retrospective cohort study of 83 178 hospitalised patients admitted between 7 days before or 14 days after PCR-confirmed SARS-CoV-2 infection within the Consortium for Clinical Characterization of COVID-19 by Electronic Health Record, an international multihealthcare system collaborative of 288 hospitals in the USA and Europe. The laboratory recovery rates and mortality rates over time were compared between the two waves of the pandemic.Primary and secondary outcome measuresThe primary outcome was all-cause mortality rate within 28 days after hospitalisation stratified by predicted low, medium and high mortality risk at baseline. The secondary outcome was the average rate of change in laboratory values during the first week of hospitalisation.ResultsBaseline Charlson Comorbidity Index and laboratory values at admission were not significantly different between the first and second waves. The improvement in laboratory values over time was faster in the second wave compared with the first. The average C reactive protein rate of change was –4.72 mg/dL vs –4.14 mg/dL per day (p=0.05). The mortality rates within each risk category significantly decreased over time, with the most substantial decrease in the high-risk group (47.1% in March–April 2020 vs 30.8% in November 2020 to January 2021, pConclusionsAdmission profiles of patients hospitalised with SARS-CoV-2 infection did not differ greatly between the first and second waves of the pandemic, but there were notable differences in laboratory improvement rates during hospitalisation. Mortality risks among patients with similar risk profiles decreased over the course of the pandemic. The improvement in laboratory values and mortality risk was consistent across multiple countries.
Published: 2022

25. Sharing pizza in n dimensions

Author: Richard Ehrenborg, Sophie Morel, Margaret Readdy, Department of Mathematics (Kentucky), University of Kentucky (UK), Unité de Mathématiques Pures et Appliquées (UMPA-ENSL), École normale supérieure de Lyon (ENS de Lyon)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Lyon (ENS Lyon), and University of Kentucky
Subjects: [MATH.MATH-CO]Mathematics [math]/Combinatorics [math.CO], FOS: Mathematics, Mathematics - Combinatorics, Combinatorics (math.CO), 51F15, 52C35, 51M20, 51M25 (Primary), 26B15 (Secondary)
Abstract: We introduce and prove the $n$-dimensional Pizza Theorem: Let $\mathcal{H}$ be a hyperplane arrangement in $\mathbb{R}^{n}$. If $K$ is a measurable set of finite volume, the {pizza quantity} of $K$ is the alternating sum of the volumes of the regions obtained by intersecting $K$ with the arrangement $\mathcal{H}$. We prove that if $\mathcal{H}$ is a Coxeter arrangement different from $A_{1}^{n}$ such that the group of isometries $W$ generated by the reflections in the hyperplanes of $\mathcal{H}$ contains the map $-\mathrm{id}$, and if $K$ is a translate of a convex body that is stable under $W$ and contains the origin, then the pizza quantity of $K$ is equal to zero. Our main tool is an induction formula for the pizza quantity involving a subarrangement of the restricted arrangement on hyperplanes of $\mathcal{H}$ that we call the {even restricted arrangement}. More generally, we prove that for a class of arrangements that we call {even} (this includes the Coxeter arrangements above) and for a {sufficiently symmetric} set $K$, the pizza quantity of $K+a$ is polynomial in $a$ for $a$ small enough, for example if $K$ is convex and $0\in K+a$. We get stronger results in the case of balls, more generally, convex bodies bounded by quadratic hypersurfaces. For example, we prove that the pizza quantity of the ball centered at $a$ having radius $R\geq\|a\|$ vanishes for a Coxeter arrangement $\mathcal{H}$ with $|\mathcal{H}|-n$ an even positive integer. We also prove the Pizza Theorem for the surface volume: When $\mathcal{H}$ is a Coxeter arrangement and $|\mathcal{H}| - n$ is a nonnegative even integer, for an $n$-dimensional ball the alternating sum of the $(n-1)$-dimensional surface volumes of the regions is equal to zero., Comment: 25 pages, to appear in Transaction of the AMS
Published: 2021
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26. Prevention of relapse to methamphetamine self-administration by environmental enrichment: involvement of glucocorticoid receptors

Author: Virginie Lardeux, Emilie Dugast, Rebecca S. Hofford, Céline Nicolas, Pauline Belujon, Marcello Solinas, Nathalie Thiriet, Michael T. Bardo, Laboratoire de neurosciences expérimentales et cliniques (LNEC), Université de Poitiers-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Kentucky, Centre hospitalier universitaire de Poitiers (CHU Poitiers), University of Kentucky (UK), and SOLINAS, Marcello
Subjects: media_common.quotation_subject, Drug-Seeking Behavior, Addiction, Self Administration, Pharmacology, Amygdala, Methamphetamine, Rats, Sprague-Dawley, 03 medical and health sciences, 0302 clinical medicine, Glucocorticoid receptor, Receptors, Glucocorticoid, Recurrence, Medicine, Animals, Glucocorticoid receptors, media_common, Craving, Environmental enrichment, business.industry, [SCCO.NEUR]Cognitive science/Neuroscience, [SCCO.NEUR] Cognitive science/Neuroscience, Antagonist, Self-administration, Mifepristone, Abstinence, 030227 psychiatry, 3. Good health, Rats, medicine.anatomical_structure, business, 030217 neurology & neurosurgery, medicine.drug
Abstract: International audience; Rationale: In rodents, environmental enrichment (EE) produces both preventive and curative effects on drug addiction, and this effect is believed to depend at least in part on EE's actions on the stress system.Objectives: This study investigated whether exposure to EE during abstinence reduces methamphetamine seeking after extended self-administration. In addition, we investigated whether these effects are associated with alterations in the levels of glucocorticoid receptors (GR) in the brain and whether administration of GR antagonists blocks methamphetamine relapse.Methods: We allowed rats to self-administer methamphetamine for twenty 14-h sessions. After 3 weeks of abstinence either in standard (SE) or EE conditions, we measured methamphetamine seeking in a single 3-h session. Then, we used western blot techniques to measure GR levels in several brain areas. Finally, in an independent group of rats, after methamphetamine self-administration and abstinence in SE, we administered the GR antagonist mifepristone, and we investigated methamphetamine seeking.Results: Exposure to EE reduced methamphetamine seeking and reversed methamphetamine-induced increases in GR levels in the ventral and dorsal hippocampus. In addition, EE decreased GR levels in the amygdala in drug-naive animals, but this effect was prevented by previous exposure to methamphetamine. Administration of mifepristone significantly decreased methamphetamine seeking.Conclusions: The anti-craving effects of EE are paralleled by restoration of methamphetamine-induced dysregulation of GR in the hippocampus. These results provide support for the hypothesis that the effect of EE on methamphetamine relapse is at least in part mediated by EE's action on the brain stress system.
Published: 2021

27. Pizza and 2-structures

Author: Ehrenborg, Richard, Morel, Sophie, Readdy, Margaret, Morel, Sophie, Unité de Mathématiques Pures et Appliquées (UMPA-ENSL), Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Lyon (ENS Lyon), Department of Mathematics (Kentucky), University of Kentucky, École normale supérieure de Lyon (ENS de Lyon)-Centre National de la Recherche Scientifique (CNRS), and University of Kentucky (UK)
Subjects: [MATH.MATH-CO] Mathematics [math]/Combinatorics [math.CO], [MATH.MATH-CO]Mathematics [math]/Combinatorics [math.CO], FOS: Mathematics, Mathematics - Combinatorics, Primary: 52B45, 20F55, 51F15, secondary: 51M20, 51M25, Combinatorics (math.CO)
Abstract: Let $\mathcal{H}$ be a Coxeter hyperplane arrangement on $\mathbb{R}^n$ with Coxeter group $W$. We assume that the map $-\mathrm{id}$ is in the group $W$ and that $\mathcal{H}$ is not of type $A_1^n$. Let $K$ be a measurable subset of $\mathbb{R}^n$ with finite volume such that $K$ is stable by $W$ and let $a\in\mathbb{R}^n$ such that $K$ contains the convex hull of $\{w(a) : w\in W\}$. The authors proved in a previous article that the alternating sum over the chambers $T$ of $\mathcal{H}$ of the volumes of the sets $T\cap(K+a)$ is zero. In this paper we give a dissection proof of this result. In fact, we lift the identity to an abstract dissection group to obtain a similar identity with the volume replaced by any valuation that is invariant under affine isometries. This includes the cases of all intrinsic volumes. Apart from some basic geometry, the main ingredient is a previous theorem of the authors (the proof of which uses only properties of Coxeter systems and closed convex polyhedral cones) where we relate the alternating sum of the values of certain valuations over the chambers of a Coxeter arrangement to similar alternating sums for simpler subarrangements called $2$-structures., Comment: 19 pages, 6 figures, submitted
Published: 2021

28. Genomic architecture of endogenous ichnoviruses reveals distinct evolutionary pathways leading to virus domestication in parasitic wasps

Author: Gabor Gyapay, Claire Lemaitre, Seán G. Brady, Frédéric Baudat, Denis Tagu, Anne-Nathalie Volkoff, Fabrice Legeai, Anthony Bretaudeau, Rebecca B. Dikow, Xin Zhou, Marc Ravallec, Stéphanie Robin, Jean-Michel Drezen, Bernardo F. Santos, Shanlin Liu, Véronique Jouan, Bruce A. Webb, Institut de Génétique, Environnement et Protection des Plantes (IGEPP), Université de Rennes (UR)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-INSTITUT AGRO Agrocampus Ouest, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Scalable, Optimized and Parallel Algorithms for Genomics (GenScale), Inria Rennes – Bretagne Atlantique, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-GESTION DES DONNÉES ET DE LA CONNAISSANCE (IRISA-D7), Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Smithsonian Institution, Diversité, Génomes & Interactions Microorganismes - Insectes [Montpellier] (DGIMI), Université de Montpellier (UM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut de recherche sur la biologie de l'insecte UMR7261 (IRBI), Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), Institut de génétique humaine (IGH), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Genoscope - Centre national de séquençage [Evry] (GENOSCOPE), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), School of Earth and Space Sciences, Peking University [Beijing], China Agricultural University Library, Beijing Genomics Institute [Shenzhen] (BGI), University of Kentucky (UK), AIPINRA project (GenomeInsect, AIP BIORESSOURCES 2012), Sackler Institute of Comparative Genomics (AMNH), ANR-12-ADAP-0001,ABC - PaPoGen,Adaptation en lutte biologique - Génomique des populations de parasitoïdes(2012), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-AGROCAMPUS OUEST, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université de Bretagne Sud (UBS)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National de Recherche en Informatique et en Automatique (Inria)-École normale supérieure - Rennes (ENS Rennes)-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-CentraleSupélec-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Bretagne Sud (UBS)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-École normale supérieure - Rennes (ENS Rennes)-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, University of Kentucky, and Université de Tours-Centre National de la Recherche Scientifique (CNRS)
Subjects: 0106 biological sciences, food.ingredient, IVSPERs, Physiology, Endogenous virus architecture, Koinobiont, [SDV]Life Sciences [q-bio], Wasps, Plant Science, Genome, Viral, macromolecular substances, 010603 evolutionary biology, 01 natural sciences, Genome, Campopleginae, General Biochemistry, Genetics and Molecular Biology, Parasitoid, Parasitoid wasp, Evolution, Molecular, 03 medical and health sciences, food, Species Specificity, Structural Biology, Polydnavirus, Animals, lcsh:QH301-705.5, Gene, Ecology, Evolution, Behavior and Systematics, 030304 developmental biology, 0303 health sciences, biology, Host Microbial Interactions, Whole Genome Sequencing, Host (biology), Cell Biology, biology.organism_classification, lcsh:Biology (General), Evolutionary biology, Polydnaviridae, Ichnovirus, General Agricultural and Biological Sciences, Bracovirus, Developmental Biology, Biotechnology, Research Article
Abstract: Background Polydnaviruses (PDVs) are mutualistic endogenous viruses inoculated by some lineages of parasitoid wasps into their hosts, where they facilitate successful wasp development. PDVs include the ichnoviruses and bracoviruses that originate from independent viral acquisitions in ichneumonid and braconid wasps respectively. PDV genomes are fully incorporated into the wasp genomes and consist of (1) genes involved in viral particle production, which derive from the viral ancestor and are not encapsidated, and (2) proviral segments harboring virulence genes, which are packaged into the viral particle. To help elucidating the mechanisms that have facilitated viral domestication in ichneumonid wasps, we analyzed the structure of the viral insertions by sequencing the whole genome of two ichnovirus-carrying wasp species, Hyposoter didymator and Campoletis sonorensis. Results Assemblies with long scaffold sizes allowed us to unravel the organization of the endogenous ichnovirus and revealed considerable dispersion of the viral loci within the wasp genomes. Proviral segments contained species-specific sets of genes and occupied distinct genomic locations in the two ichneumonid wasps. In contrast, viral machinery genes were organized in clusters showing highly conserved gene content and order, with some loci located in collinear wasp genomic regions. This genomic architecture clearly differs from the organization of PDVs in braconid wasps, in which proviral segments are clustered and viral machinery elements are more dispersed. Conclusions The contrasting structures of the two types of ichnovirus genomic elements are consistent with their different functions: proviral segments are vehicles for virulence proteins expected to adapt according to different host defense systems, whereas the genes involved in virus particle production in the wasp are likely more stable and may reflect ancestral viral architecture. The distinct genomic architectures seen in ichnoviruses versus bracoviruses reveal different evolutionary trajectories that have led to virus domestication in the two wasp lineages.
Published: 2020

29. Discussion on radioactive iodine treatment of hyperthyroidism and the risk of induced cancer

Author: Slimane Zerdoud, Kenneth B. Ain, Elif Hindié, Anca M. Avram, University of Kentucky, Institut Universitaire du Cancer de Toulouse - Oncopole (IUCT Oncopole - UMR 1037), CHU Toulouse [Toulouse]-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of radiology (Massachusetts General Hospital), Massachusetts General Hospital [Boston], University of Kentucky (UK), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM), and CCSD, Accord Elsevier
Subjects: Thyroid nodules, Pediatrics, medicine.medical_specialty, Radiological and Ultrasound Technology, business.industry, [SDV]Life Sciences [q-bio], Biophysics, Cancer, Radioiodine therapy, Disease, medicine.disease, 3. Good health, 030218 nuclear medicine & medical imaging, [SDV] Life Sciences [q-bio], 03 medical and health sciences, 0302 clinical medicine, Increased risk, medicine, Radiology, Nuclear Medicine and imaging, Radioactive iodine, business, Initial therapy, Short duration
Abstract: Iodine-131 (131I, radioiodine) has been used for over eight decades for the treatment of Graves’ disease, either as initial therapy or following failure of thionamides, as well as for the treatment of autonomous thyroid nodules. 131I treatment is simple to administer, effective, and relatively inexpensive. Recently, there has been some turmoil after a study published in JAMA Internal Medicine reported an increased risk of cancer from 131I treatment. The impact was of short duration however, as the paper received severe criticisms from many nuclear medicine physicians as well as from endocrinologists. Here we explain why that paper's conclusions are doubtful. We also review the major data on the topic of 131I therapy of hyperthyroidism and the risk of cancer.
Published: 2020

30. Derivation and the morphological complexity of three French-based creoles

Author: Gregory Stump, Fabiola Henri, Delphine Tribout, University at Buffalo [SUNY] (SUNY Buffalo), State University of New York (SUNY), University of Kentucky, Savoirs, Textes, Langage (STL) - UMR 8163 (STL), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Peter Arkadiev, Francesco Gardani, and University of Kentucky (UK)
Subjects: Algebra, [SHS.LANGUE]Humanities and Social Sciences/Linguistics, Mathematics
Abstract: International audience; Creolistic research persistently asserts the simplicity of creoles, citing as evidence the claimed poverty of creole morphology. Yet, creoles not only exhibit morphology, but evince a surprising degree of morphological complexity. Drawing on the evidence of derivational morphology from three different French-based creoles − Mauritian (Indian Ocean), Haitian, and Guadeloupean (Caribbean) – the current contribution provides new evidence for this claim. It pursues a view of morphological complexity where the interaction of a lexeme's inventory of forms with its participation in deverbal derivation contributes to the integrative complexity of a language's morphology. Such a perspective is compatible with psycholinguistic approaches to language acquisition and language change.
Published: 2020

31. Characterization and Enzyme Engineering of a Hyperthermophilic Laccase Toward Improving Its Activity in Ionic Liquid

Author: David W. Rodgers, Jian Shi, Joseph C. Stevens, Claire Dumon, University of Kentucky, CIMES - Catalysis and Enzyme Molecular Engineering (TBI-CIMES), Toulouse Biotechnology Institute (TBI), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), National Science Foundation (NSF) 1355438, National Institute of Food and Agriculture, United States Department of Agriculture, Hatch-Multistate project 1018315, Chateaubriand Fellowship of the Office for Science & Technology of the Embassy of France in the United States, University of Kentucky (UK), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), and Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
Subjects: Economics and Econometrics, [SDV.BIO]Life Sciences [q-bio]/Biotechnology, biocatalysis, 020209 energy, [SDV]Life Sciences [q-bio], rational design, Energy Engineering and Power Technology, lignin, lcsh:A, 02 engineering and technology, laccase, ionic liquids, chemistry.chemical_compound, 0202 electrical engineering, electronic engineering, information engineering, Lignin, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], Laccase, biology, Renewable Energy, Sustainability and the Environment, Chemistry, Rational design, Active site, Thermus thermophilus, 021001 nanoscience & nanotechnology, biology.organism_classification, Combinatorial chemistry, enzyme engineering, Fuel Technology, Docking (molecular), Biocatalysis, Ionic liquid, biology.protein, lcsh:General Works, 0210 nano-technology
Abstract: International audience; Ionic liquids (ILs) are organic salts molten at room temperature that can be used for a wide variety of applications. Many ILs, such as 1-ethyl-3-methylimidazolium acetate ([C(2)C(1)Im][OAc]), have been shown to remove a significant fraction of the complex biopolymer lignin from biomass during pretreatment. Valorizing ligninviabiological pathways (e.g., enzymes) holds promise but is limited by the low biocompatibility of many ILs used for pretreatment. The discovery of thermostable enzymes and the application of enzyme engineering techniques have yielded biocatalysts capable of withstanding high concentrations of ILs. Converting lignin from a waste product to value-added chemicals is vital to the success of future cellulosic biorefineries. To that end, we screened the activity of the lignolytic enzyme laccase from a hyperthermophilic bacterium (Thermus thermophilus) in aqueous [C(2)C(1)Im][OAc]. Despite the thermophilicity (T-opt> 90 degrees C) of this laccase, significant activity loss (>50%) was observed in only 2% (w/v) [C(2)C(1)Im][OAc]. Kinetics studies show that the IL can bind to the free enzyme and the enzyme-substrate complex. Docking simulations suggest that the cation favors binding to a region close to the active site. We then used a rational design strategy to improve the activity of the laccase in [C(2)C(1)Im][OAc]. A total of 8 single amino acid mutations were made; however, there were no significant improvements in the activity of the mutants in [C(2)C(1)Im][OAc] compared to the wild type. The results of this study shed light on the complex nature of enzyme-IL interactions and the challenges faced when designing a biological lignin valorization strategy.
Published: 2020

32. General destabilizing effects of eutrophication on grassland productivity at multiple spatial scales

Author: Martin Schütz, Peter B. Adler, Melinda D. Smith, Lars A. Brudvig, Yann Hautier, Carlos Alberto Arnillas, Michel Loreau, Andy Hector, Marc W. Cadotte, Forest Isbell, Juan Alberti, Mahesh Sankaran, Jonathan D. Bakker, Peter A. Wilfahrt, John W. Morgan, Pablo Luis Peri, Amandine Hansar, Jonathan S. Lefcheck, Peter B. Reich, Sally E. Koerner, Kevin R. Wilcox, Christiane Roscher, Philip A. Fay, Miguel N. Bugalho, Edwin Pos, Mick Crawley, Elizabeth T. Borer, Pengfei Zhang, Rebecca L. McCulley, Anita C. Risch, Laura E. Dee, Jodi N. Price, Maria C. Caldeira, Johannes M. H. Knops, Oliver Carroll, Nico Eisenhauer, Risto Virtanen, Sally A. Power, Carly J. Stevens, Andrew S. MacDougall, Anu Eskelinen, Benjamin Gilbert, Jarrett E. K. Byrnes, Glenda M. Wardle, Scott L. Collins, Eric W. Seabloom, Joslin L. Moore, Akira Mori, Shaopeng Wang, Pedro M. Tognetti, Kimberly J. Komatsu, Pedro Daleo, Department of Biology, Faculty of Sciences, Utrecht University, Utrecht University [Utrecht], Lanzhou University, Shandong University, Ministry of Justice Hub for Research & Practice in Eco-Environmental Forensics, Station d'écologie théorique et expérimentale (SETE), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), University of Wyoming (UW), University of Minnesota [Twin Cities] (UMN), University of Minnesota System, University of Massachusetts [Boston] (UMass Boston), University of Massachusetts System (UMASS), University of North Carolina [Greensboro] (UNCG), University of North Carolina System (UNC), Smithsonian Environmental Research Center (SERC), University of Oxford, Utah State University (USU), Instituto de Investigaciones Marinas y Costeras [Mar del Plata] (IIMyC), Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] (CONICET)-Facultad de Ciencias Exactas y Naturales [Mar del Plata], Universidad Nacional de Mar del Plata [Mar del Plata] (UNMdP)-Universidad Nacional de Mar del Plata [Mar del Plata] (UNMdP), University of Toronto at Scarborough, University of Washington [Seattle], Michigan State University System, Universidade de Lisboa = University of Lisbon (ULISBOA), University of Guelph, Imperial College London, The University of New Mexico [Albuquerque], University of Colorado [Boulder], German Centre for Integrative Biodiversity Research (iDiv), Leipzig University, Helmholtz Zentrum für Umweltforschung = Helmholtz Centre for Environmental Research (UFZ), University of Oulu, USDA-ARS Grassland, Soil, and Water Research Laboratory, Temple, Department of Ecology and Evolutionary Biology [University of Toronto] (EEB), University of Toronto, CEREEP-Ecotron Ile de France (UMS 3194), Département de Biologie - ENS Paris, École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Xi'an Jiaotong-Liverpool University [Suzhou], University of Kentucky (UK), Monash University [Clayton], La Trobe University [Melbourne], Yokohama National University, INTA UNPA CONICET SANTA CRUZ ARG, Partenaires IRSTEA, Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), Western Sydney University, Charles Sturt University [Australia], Department of Forest Resources, University of Minnesota, St. Paul, MN, USA, Swiss Federal Institute for Forest, Snow and Landscape Research WSL, National Centre for Biological Sciences, TIFR, Bangalore, University of Leeds, Colorado State University [Fort Collins] (CSU), Graduate Degree Program in Ecology, Colorado State University, Lancaster University, Universidad de Buenos Aires [Buenos Aires] (UBA), The University of Sydney, Peking University [Beijing], Department of Ecology, Evolution, and Behavior, University of Minnesota System-University of Minnesota System, Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD), Smithsonian Environmental Research Center, University of Oxford [Oxford], Facultad de Ciencias Exactas y Naturales [Mar del Plata], Universidad Nacional de Mar del Plata [Mar del Plata] (UNMdP)-Universidad Nacional de Mar del Plata [Mar del Plata] (UNMdP)-Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] (CONICET), University of Toronto [Scarborough, Canada], Universidade de Lisboa (ULISBOA), Centre National de la Recherche Scientifique (CNRS)-Département de Biologie - ENS Paris, École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Kentucky, and Nature Publishing Group
Subjects: 0106 biological sciences, Grassland ecology, Spatial scales, Environmental change, Beta diversity, Biodiversity, spatial variation, Functional Ecosystem Change, 01 natural sciences, Plantas, Biomass, lcsh:Science, ComputingMilieux_MISCELLANEOUS, Índices de Diversidad, Diversity Alpha, Biomass (ecology), Ecology, spatial scales, Life Sciences, food and beverages, Phosphorus, Eutrophication, Plants, Pastizales, Productivity (ecology), Abundancia, Grasslands, Nutrient cycles, EUTROPHICATION, Escalas de Análisis, Diversity Indices, Preservación de las Funcionalidades de los Pastizales, Eutrofización, Primary Productivity, Nitrogen, [SDE.MCG]Environmental Sciences/Global Changes, Science, Diversidad Biológica, CONSERVATION, ECOLOGY, General Biochemistry, Genetics and Molecular Biology, Article, Productividad Primaria, Ecosystem, Community ecology, PRESERVATION, Author Correction, Estabilidad, PLANT DIVERSITY, 010604 marine biology & hydrobiology, 15. Life on land, destabilizing effects, ENVIRONMENTAL CHANGE, Diversity Beta, Ciclo de nutrientes en ecosistemas, Fósforo, lcsh:Q, Species Richness, Cambios en las Funciones del Ecosistema, Fertilizer Application, [SDV]Life Sciences [q-bio], Ecology and Evolutionary Biology, General Physics and Astronomy, purl.org/becyt/ford/1 [https], Abundance, Abonos, Riqueza de Especies, Productivity, Diversidad Beta, 2. Zero hunger, Praderas, grassland productive, Multidisciplinary, LARGE SCALE STABILITY, Preserving Grassland Functional Stability, Nitrógeno, chronic fertilization, respiratory system, Biota, Grassland, Implicancias en la productividad, Stability, Diversidad Alfa, Biology, ENVIRONMENTAL FLUCTUATIONS, 010603 evolutionary biology, Models, Biological, [SDV.EE.ECO]Life Sciences [q-bio]/Ecology, environment/Ecosystems, Productividad de la Tierra, Ecosystem services, purl.org/becyt/ford/1.6 [https], grassland productivity, Pastures, Plant community, General Chemistry, plant diversity, Fertilization, Spatial variability, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, COMMUNITIES, human activities
Abstract: Eutrophication is a widespread environmental change that usually reduces the stabilizing effect of plant diversity on productivity in local communities. Whether this effect is scale dependent remains to be elucidated. Here, we determine the relationship between plant diversity and temporal stability of productivity for 243 plant communities from 42 grasslands across the globe and quantify the effect of chronic fertilization on these relationships. Unfertilized local communities with more plant species exhibit greater asynchronous dynamics among species in response to natural environmental fluctuations, resulting in greater local stability (alpha stability). Moreover, neighborhood communities that have greater spatial variation in plant species composition within sites (higher beta diversity) have greater spatial asynchrony of productivity among communities, resulting in greater stability at the larger scale (gamma stability). Importantly, fertilization consistently weakens the contribution of plant diversity to both of these stabilizing mechanisms, thus diminishing the positive effect of biodiversity on stability at differing spatial scales. Our findings suggest that preserving grassland functional stability requires conservation of plant diversity within and among ecological communities., Eutrophication has been shown to weaken diversity-stability relationships in grasslands, but it is unclear whether the effect depends on scale. Analysing a globally distributed network of grassland sites, the authors show a positive role of beta diversity and spatial asynchrony as drivers of stability but find that nitrogen enrichment weakens the diversity-stability relationships at different spatial scales.
Published: 2020

33. Clozapine is strongly associated with the risk of pneumonia and inflammation

Author: Can Jun Ruan, Chuanyue Wang, Hélène Verdoux, Jose de Leon, University of Kentucky, Beijing Anding Hospital [Pékin, Chine], Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Bodescot, Myriam, and University of Kentucky (UK)
Subjects: medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), lcsh:RC435-571, [SDV.MHEP.PSM] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, Clinical Neurology, Inflammation, Dose level, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, 03 medical and health sciences, 0302 clinical medicine, lcsh:Psychiatry, Internal medicine, medicine, Clozapine, [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, [SDV.MHEP.ME] Life Sciences [q-bio]/Human health and pathology/Emerging diseases, PharmacoEpi-Drugs, psychopharmacology, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, business.industry, Forum, High mortality, medicine.disease, 3. Good health, 030227 psychiatry, schizophrenia, Psychiatry and Mental health, Pneumonia, Neurology, Schizophrenia, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, [SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, Neurology (clinical), Psychopharmacology, medicine.symptom, business, 030217 neurology & neurosurgery, medicine.drug
Abstract: International audience; Clinicians need to remember that (1) systemic inflammations can increase clozapine level; (2) clozapine, by itself, can cause inflammation, particularly during titration that is too rapid for that patient; (3) clozapine may increase the risk of infection; and (4) more specifically, clozapine may be particularly strongly associated with the risk of pneumonia. Pneumonia appears to be associated with high mortality in clozapine patients around the world. Clinicians who are alert to the risk of pneumonia in clozapine patients may significantly decrease mortality in clozapine patients. There is no data on COVID-19 infections in clozapine patients, but based on what we know about clozapine pharmacology, we can hypothesise that clozapine, possibly by impairing immunological mechanisms, may increase the risk of pneumonia in infected patients. More importantly, once fever and/or pneumonia develops, the clozapine dose should be cut in half to decrease the risk of clozapine intoxication. If there is any doubt that in spite of halving the dose there are still signs of clozapine intoxication, completely stopping clozapine may be indicated. Once the signs of inflammation and fever have disappeared, the clozapine dose can be increased to the prior dosage level.
Published: 2020

34. ICDP workshop on the Lake Tanganyika Scientific Drilling Project: a late Miocene–present record of climate, rifting, and ecosystem evolution from the world's oldest tropical lake

Author: Russell, J., Barker, P., Cohen, A., Ivory, S., Kimirei, I., Lane, C., Leng, M., Maganza, N., McGlue, M., Msaky, E., Noren, A., Park Boush, L., Salzburger, W., Scholz, C., Tiedemann, R., Nuru, S., Albrecht, C., Ali, R., Arrowsmith, R., Asanga, D., Asmerom, Y., Bakundukize, C., Bauersachs, T., Beck, C., Berke, M., Beverley, E., Blaauw, M., Boush, L., Brown, E., Campisano, C., Carrapa, B., Castaûeda, I., Dee, S., Deino, A., Ebinger, C., Ellis, G., Foerster, V., Fontijn, K., Gehrels, G., Indemaur, A., Jovanovska, E., Junginger, A., Kaboth, S., Kallmeyer, J., King, L., Konecky, B., Mark, D., McIntyre, P., Michel, E., Mkuu, D., Morgan, L., Mtetela, C., Muderwha, N., Muirhead, J., Mumbi, C., Muschick, M., Nahimana, D., Ngowi, V., Njiko, P., Nkenyeli, S., Nkotagu, H., Ntakimazi, G., Oppo, D., Purkamo, L., Rick, J., Roberts, H., Ronco, F., Sangweni, C., Shaghude, Y., Shigela, J., Shillington, D., Sophia, C., Sier, M., Soreghan, M., Spanbauer, T., Spencer-Jones, C., Staff, R., Stone, J., Todd, J., Trauth, M., van Bocxlaer, B., Viehberg, F., Vogel, H., Vonhof, H., Wolff, C., Wu, Q., Yost, C., Zeeden, C., Brown University, Lancaster University, Department of Geosciences, University of Arizona, University of Arizona, Pennsylvania State University (Penn State), Penn State System, Tanzania Fisheries Research Institute, University of Cambridge [UK] (CAM), British Geological Survey [Keyworth], British Geological Survey (BGS), Tanzania Petroleum Development Corporation, University of Kentucky, University of Minnesota [Duluth], University of Minnesota System, University of Connecticut (UCONN), University of Basel (Unibas), Syracuse University, University of Potsdam, Justus-Liebig-Universität Gießen (JLU), Petroleum Upstream Regulatory Authority, Arizona State University [Tempe] (ASU), The University of New Mexico [Albuquerque], University of Burundi, University of Kiel, Hamilton College, University of Notre Dame [Indiana] (UND), University of Houston, Queen's University [Kingston, Canada], University of Massachusetts [Amherst] (UMass Amherst), University of Massachusetts System (UMASS), Rice University [Houston], Berkeley Geochronology Center (BGC), Tulane University, United States Geological Survey (USGS), University of Cologne, University of Brussels, University of Tübingen, GeoForschungsZentrum - Helmholtz-Zentrum Potsdam (GFZ), University of Rhode Island (URI), University of Washington [Seattle], Scottish Universities Environmental Research Centre (SUERC), University of Glasgow-University of Edinburgh, University of Wisconsin-Madison, The Natural History Museum [London] (NHM), University of Dar es Salaam (UDSM), Hydrobiology Laboratory - Uvira, Tanzania Wildlife Research Institute (TAWIRI), University of Bern, University of Louisiana, Geological Survey of Finland, University of Wyoming (UW), Aberystwyth University, Lamont-Doherty Earth Observatory (LDEO), Columbia University [New York], Nanjing Institute of Geography and Limnology (Niglas), Chinese Academy of Sciences [Beijing] (CAS), CNIEH, University of Oklahoma (OU), University of Texas at Austin [Austin], Durham University, University of Glasgow, Indiana State University, Évolution, Écologie et Paléontologie (Evo-Eco-Paleo) - UMR 8198 (Evo-Eco-Paléo), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Max Planck Institute for Chemistry (MPIC), Max-Planck-Gesellschaft, Leibnitz Institute of Applied Geophysics, Department of Geosciences [University of Arizona], University of Kentucky (UK), University of Potsdam = Universität Potsdam, Justus-Liebig-Universität Gießen = Justus Liebig University (JLU), Université libre de Bruxelles (ULB), Geological Survey of Finland = Geologian tutkimuskeskus tuottaa (GKT), and Évolution, Écologie et Paléontologie (Evo-Eco-Paleo) - UMR 8198 (Evo-Eco-Paléo (EEP))
Subjects: 010504 meteorology & atmospheric sciences, Environmental change, Earth science, [SDE.MCG]Environmental Sciences/Global Changes, Energy Engineering and Power Technology, Context (language use), Stratigraphie, 010502 geochemistry & geophysics, Sciences de l'ingénieur, 01 natural sciences, Paleoclimatology, Tropical climate, 550 Earth sciences & geology, 0105 earth and related environmental sciences, Mechanical Engineering, Scientific drilling, Géochronologie, Sédimentologie, lcsh:QE1-996.5, Biosphere, 15. Life on land, lcsh:Geology, Mécanique sectorielle, 13. Climate action, [SDU.STU.CL]Sciences of the Universe [physics]/Earth Sciences/Climatology, Paleoecology, 570 Life sciences, biology, Climatologie, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, Global cooling, Geology, Géodynamique et tectonique
Abstract: The Neogene and Quaternary are characterized by enormous changes in global climate and environments, including global cooling and the establishment of northern high-latitude glaciers. These changes reshaped global ecosystems, including the emergence of tropical dry forests and savannahs that are found in Africa today, which in turn may have influenced the evolution of humans and their ancestors. However, despite decades of research we lack long, continuous, well-resolved records of tropical climate, ecosystem changes, and surface processes necessary to understand their interactions and influences on evolutionary processes. Lake Tanganyika, Africa, contains the most continuous, long continental climate record from the mid-Miocene (∼ 10 Ma) to the present anywhere in the tropics and has long been recognized as a top-priority site for scientific drilling. The lake is surrounded by the Miombo woodlands, part of the largest dry tropical biome on Earth. Lake Tanganyika also harbors incredibly diverse endemic biota and an entirely unexplored deep microbial biosphere, and it provides textbook examples of rift segmentation, fault behavior, and associated surface processes. To evaluate the interdisciplinary scientific opportunities that an ICDP drilling program at Lake Tanganyika could offer, more than 70 scientists representing 12 countries and a variety of scientific disciplines met in Dar es Salaam, Tanzania, in June 2019. The team developed key research objectives in basin evolution, source-to-sink sedimentology, organismal evolution, geomicrobiology, paleoclimatology, paleolimnology, terrestrial paleoecology, paleoanthropology, and geochronology to be addressed through scientific drilling on Lake Tanganyika. They also identified drilling targets and strategies, logistical challenges, and education and capacity building programs to be carried out through the project. Participants concluded that a drilling program at Lake Tanganyika would produce the first continuous Miocene-present record from the tropics, transforming our understanding of global environmental change, the environmental context of human origins in Africa, and providing a detailed window into the dynamics, tempo and mode of biological diversification and adaptive radiations., SCOPUS: ar.j, info:eu-repo/semantics/published
Published: 2020

35. Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci

Author: Daniele Cusi, Etsuo Chihara, Leyla Al-Jasim, Ya Xing Wang, Tero Kivelä, Jinghong Sang, Adeyinka O. Ashaye, Bowen Zhao, Tan Do, Susanne Moebus, Ursula Schlötzer-Schrehardt, Shamira A. Perera, Augustine W O Cheong, Afsaneh Naderi Beni, Francisco A. Escudero-Domínguez, Yoshiaki Kiuchi, Tomomi Higashide, DS Klobassa, Friedrich E. Kruse, Nicole Weisschuh, Chunyan Qiao, Muhammad Imran Khan, Martin L. Hibberd, Arthur J. Sit, Jamie E Craig, Akitoshi Yoshida, Periasamy Sundaresan, Humaira Ayub, Kathryn P. Burdon, Jonathan G Crowston, Kazunori Miyata, Marisa Cruz-Aguilar, Markus M. Nöthen, Hasnaa Lamari, Michael A. Hauser, Louis R. Pasquale, Anneke I. den Hollander, Eija Vesti, Ursula Hoja, Raphael Q Soh, Burcu Kasım, Adeola O Onakoya, Rachel W. Kuchtey, Eugeny L. Akopov, Liang Xu, Juan Carlos Zenteno, Chaiwat Teekhasaenee, Saleh A. Al-Obeidan, Eleftherios Anastasopoulos, Anita S Y Chan, Nagahisa Yoshimura, John Kuchtey, Naris Kitnarong, Yaan Fun Chong, Boonsong Wanichwecharugruang, R.R. Fayzrakhmanov, Paul Mitchell, N Kalpana, Unnur Thorsteinsdottir, Kei Tashiro, Rajesh Kumar, Jin Wook Jeoung, Deepak P. Edward, Frederico Martinon-Torres, Bilge Batu, Anavaj Sakuntabhai, Robert N. Weinreb, Héctor González-Iglesias, Sasan Moghimi, Jia Nee Foo, Nkechi J Uche, Karen Curtin, Kenji Inoue, Lingam Vijaya, Makoto Aihara, Dilek Aktas, Norimoto Gotoh, Wasu Supakontanasan, Laura Dallorto, Takako Sugimoto, Jonathan L. Haines, Olusola Olawoye, Janey L. Wiggs, Sripriya Sarangapani, Craig J. Chaya, Theofanis Pappas, Fotis Topouzis, Eranga N. Vithana, Steffen Heegaard, Fridbert Jonasson, Kazuhiko Mori, Idakwo Ugbede, Hongyan Jia, Anthi Chatzikyriakidou, Robert P. Igo, Soon Cheol Cha, Yueming Chen, Su-Ling Ho, Zhenglin Yang, Jost B. Jonas, Francesca Pasutto, Ken Hayashi, Rahat Husain, Georg Mossböck, S Fabian Lerner, R. Rand Allingham, Priti Sahay, Fumihiko Matsuda, Yanin Suwan, Teresa Rolle, Robert Ritch, Peter Kraft, Trevor R. Carmichael, Kar Seng Sim, Raheel Qamar, Gordana Sunaric Megevand, Tomasz Zarnowski, Shazia Micheal, Scott Thomas, Paolo Frezzotti, Vera Vysochinskaya, Linda M. Zangwill, Alina Popa Cherecheanu, Tin Aung, Jessica N. Cooke Bailey, Kyu Hyung Park, Edward Dervan, Suhanya Okeke, Pablo Fornero, Sidi M Ezzouhairi, Pascal Reynier, Gudmar Thorleifsson, Michael V. Dubina, Kazuhisa Sugiyama, Sylvain Roy, Per Kappelgaard, Mineo Ozaki, Vijayan Saravanan, Carlo Lavia, Wenda L. Greer, Takanori Mizoguchi, Alireza Lashay, A. Binder, Daniel Berner, Su Qin Peh, Balram Chowbay, Nino Kobakhidze, Ifeoma N. Asimadu, Delia Sivori, Gopalakrishnan Prakadeeswari, Alexandros Lambropoulos, Michael Coote, Sergei Y. Astakhov, Shahin Yazdani, Dan Milea, Montserrat García, Lydia Álvarez, Kenji Yamashiro, Soumya Raychaudhuri, Pratap Challa, Aparna Rao, Jae H. Kang, Khai Koon Heng, Richard K. Lee, Tien Yin Wong, Alex W. Hewitt, Yoko Ikeda, Kessara Pathanapitoon, Panayiota Founti, Daniella Bach-Holm, Emmanuelle Souzeau, Margaret A. Pericak-Vance, Michèle Ramsay, Nkiru Kizor-Akaraiwe, Yosai Mori, Antonio Maria Fea, Chandrashekaran Shivkumar, Xiao Yu Ng, Jie Jin Wang, Erika Salvi, Giang T T Nguyn, Steffen Uebe, Tamara Zompa, Anne L. Coleman, Werner Zenz, Min Sagong, Luis Fernández-Vega Cueto, Farah Akhtar, Susan Williams, Sarah C. Nelson, Bradford J. Shingleton, Ryuichi Ideta, Leon W. Herndon, Zheng Li, Murat Irkec, M. Roy Wilson, Ewa Kosior-Jarecka, Christian Y. Mardin, Mozhgan Rezaei Kanavi, Tsutomu Ohashi, Abderrahman Rafei, Rengaraj Venkatesh, Stefan Herms, George Chichua, Mohammad Pakravan, Robyn M. Rautenbach, Shi Qi Mok, Trình V Nguyn, Patricio G. Schlottmann, Nassim Khatibi, Daniel Gaston, Masaru Inatani, Morio Ueno, Mukharram M. Bikbov, Eoin Silke, Homa Naderifar, Linda Hansapinyo, Paolo Manunta, Z. Xie, Urszula Lukasik, Eray Atalay, Lulin Huang, Xuyang Liu, Chie Sotozono, Shuang Ru Goh, John H. Fingert, Richard A. Mills, Khaled K. Abu-Amero, Xiao Yin Chen, Matthias Zenkel, Sergo Tabagari, Irma Järvelä, Xueyi Chen, Stéphanie Leruez, Yury S. Astakhov, Sonia Davila, Yildirim Nilgün, Ronnie George, Shin-ichi Manabe, Miguel Coca-Prados, Masahiro Miyake, Ignacio Lischinsky, Rogelio González-Sarmiento, Arkasubhra Ghosh, A. Emelyanov, Çilingir Oguz, Masakazu Nakano, Rohit Shetty, Karen Bedard, Toshiya Sakurai, Yutao Liu, Barbara M Wirostko, Hui Zhang, Ulrich-Christoph Welge-Luessen, Toshiaki Kubota, Vania Castro, Hip X Nguyn, Liyun Jia, Ari Ziskind, Hideki Chuman, Andrew C. Orr, Satoko Nakano, Daniela Paoli, Masahide Yanagi, Aravind Haripriya, Kari Stefansson, Pedro Pablo Rodríguez-Calvo, Hui Meng Soo, Chiea Chuen Khor, Gyulli M. Kazakbaeva, Osvaldo Cuello, Mei Chin Lee, Ki Ho Park, Natalia Porporato, Lourdes de Juan Marcos, Ching-Yu Cheng, Shigeyasu Kazama, Shigeru Kinoshita, Axel M. Hillmer, Alan S. Crandall, Victor H. K. Yong, Ohoud Owaidhah, Rodolfo Perez Grossmann, Jeeyun Ahn, André Reis, Nevbahar Tamçelik, Satoshi Ishiko, Antonio Salas, Ningli Wang, Singapore Eye Research Institute [Singapore] (SERI), Ozaki Eye Hospital [Miyazaki], Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), deCODE genetics [Reykjavik], Mizoguchi Eye Hospital [Sasebo], Case Western Reserve University [Cleveland], Aravind Eye Hospital [Madurai, India], University of the Witwatersrand [Johannesburg] (WITS), Pavlov First Saint Petersburg State Medical University [St. Petersburg], Dalhousie University [Halifax], Flinders University [Adelaide, Australia], Kyoto Prefectural University of Medicine [Kyoto, Japon], King Saud University [Riyadh] (KSU), Genome Institute of Singapore (GIS), Aravind Medical Research Foundation (AMRF), Université de Médecine Carol Davila, Harvard Medical School [Boston] (HMS), University of Washington [Seattle], Hayashi Eye Hospital [Fukuoka], Shinjo Eye Clinic [Nagoya], Medical University of Lublin, Inoue Eye Hospital [Tokyo], Hacettepe University = Hacettepe Üniversitesi, Universidad de Oviedo [Oviedo], Kanazawa University (KU), Department of Medical and Clinical Genetics [Helsinki], Haartman Institute [Helsinki], Faculty of Medecine [Helsinki], Helsingin yliopisto = Helsingfors universitet = University of Helsinki-Helsingin yliopisto = Helsingfors universitet = University of Helsinki-Faculty of Medecine [Helsinki], Helsingin yliopisto = Helsingfors universitet = University of Helsinki-Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Organizacion Medica de Investigacion (OMI BUENOS AIRES), Fundacion para el Estudio del Glaucoma [Buenos Aires], Chercheur indépendant, Eskisehir Osmangazi University, Ufa Eye Research Institute [Bashkortostan], Seoul National University Hospital, Yeungnam University [South Korea], Kyoto University, Universidad Nacional Autónoma de México = National Autonomous University of Mexico (UNAM), Universität Heidelberg [Heidelberg] = Heidelberg University, Birla Institute of Scientific Research (BISR), B. M. Birla Science and Technology Center, Faculty of Computer Science, Department of Pathology and Immunology, Geneva University Hospital (HUG), Key Laboratory for Information System Security, ministry of education, Numerical modeling and high performance computing for evolution problems in complex domains and heterogeneous media (NACHOS), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire Jean Alexandre Dieudonné (LJAD), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Institute of Human Genetics [Erlangen, Allemagne], Department of Ophthalmology, School of Medicine [Thessaloniki, Grèce], Aristotle University of Thessaloniki, Università degli Studi di Siena = University of Siena (UNISI), Department of Medicine, Surgery, and Dentistry, University of Milano, Japan Advanced Institute of Science and Technology (JAIST), Etudes génomiques trans-ethniques des maladies multifactorielles, Kyoto University-Institut National de la Santé et de la Recherche Médicale (INSERM), Fondation Ophtalmologique Adolphe de Rothschild [Paris], Archaeogenetics Laboratory, Génétique fonctionnelle des Maladies infectieuses - Functional Genetics of Infectious Diseases, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Rheinische Friedrich-Wilhelms-Universität Bonn, University of Kentucky (UK), Helsinki University Eye Hospital, Turku University Hospital, Turku, Finland, COMSATS Institute of Information Technology (CIIT), Department of Epidemiology, Harvard School of Public Health, University of Miami Leonard M. Miller School of Medicine (UMMSM), Brigham and Women's Hospital [Boston], Department of Neuroscience and Pharmacology, Section of Eye Pathology, University of Copenhagen, University of Copenhagen = Københavns Universitet (UCPH), Helsingin yliopisto = Helsingfors universitet = University of Helsinki, University of California [San Diego] (UC San Diego), University of California (UC), University of Iceland [Reykjavik], New York Eye and Ear Infirmary of Mount Sinai [New York] (NYEE), Oita University Faculty of Medicine [Oita, Japon], Radboud University Medical Center [Nijmegen], Oogheelkunde, RS: FHML non-thematic output, Kyoto University [Kyoto], Universidad Nacional Autónoma de México (UNAM), Universität Heidelberg [Heidelberg], Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire Jean Alexandre Dieudonné (JAD), Dipartimento di Scienze oftalmologiche e Neurochirurgiche, Universita' degli Studi di Siena, Siena, Kyoto University [Kyoto]-Institut National de la Santé et de la Recherche Médicale (INSERM), Rothschild Hospital, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), University of Kentucky, University of Copenhagen = Københavns Universitet (KU), University of California, Aung, Tin, Ozaki, Mineo, Lee, Mei Chin, Schlötzer Schrehardt, Ursula, Thorleifsson, Gudmar, Mizoguchi, Takanori, Igo, Robert P, Haripriya, Aravind, Williams, Susan E, Astakhov, Yury S, Orr, Andrew C, Burdon, Kathryn P, Nakano, Satoko, Mori, Kazuhiko, Abu Amero, Khaled, Hauser, Michael, Li, Zheng, Prakadeeswari, Gopalakrishnan, Bailey, Jessica N. Cooke, Cherecheanu, Alina Popa, Kang, Jae H, Nelson, Sarah, Hayashi, Ken, Manabe, Shin Ichi, Kazama, Shigeyasu, Zarnowski, Tomasz, Inoue, Kenji, Irkec, Murat, Coca Prados, Miguel, Sugiyama, Kazuhisa, Järvelä, Irma, Schlottmann, Patricio, Lerner, S. Fabian, Lamari, Hasnaa, Nilgün, Yildirim, Bikbov, Mukharram, Park, Ki Ho, Cha, Soon Cheol, Yamashiro, Kenji, Zenteno, Juan C, Jonas, Jost B, Kumar, Rajesh S, Perera, Shamira A, Chan, Anita S. Y, Kobakhidze, Nino, George, Ronnie, Vijaya, Lingam, Do, Tan, Edward, Deepak P, de Juan Marcos, Lourde, Pakravan, Mohammad, Moghimi, Sasan, Ideta, Ryuichi, Bach Holm, Daniella, Kappelgaard, Per, Wirostko, Barbara, Thomas, Samuel, Gaston, Daniel, Bedard, Karen, Greer, Wenda L, Yang, Zhenglin, Chen, Xueyi, Huang, Lulin, Sang, Jinghong, Jia, Hongyan, Jia, Liyun, Qiao, Chunyan, Zhang, Hui, Liu, Xuyang, Zhao, Bowen, Wang, Ya Xing, Xu, Liang, Leruez, Stéphanie, Reynier, Pascal, Chichua, George, Tabagari, Sergo, Uebe, Steffen, Zenkel, Matthia, Berner, Daniel, Mossböck, Georg, Weisschuh, Nicole, Hoja, Ursula, Welge Luessen, Ulrich Christoph, Mardin, Christian, Founti, Panayiota, Chatzikyriakidou, Anthi, Pappas, Theofani, Anastasopoulos, Eleftherio, Lambropoulos, Alexandro, Ghosh, Arkasubhra, Shetty, Rohit, Porporato, Natalia, Saravanan, Vijayan, Venkatesh, Rengaraj, Shivkumar, Chandrashekaran, Kalpana, Narendran, Sarangapani, Sripriya, Kanavi, Mozhgan R, Beni, Afsaneh Naderi, Yazdani, Shahin, Lashay, Alireza, Naderifar, Homa, Khatibi, Nassim, Fea, Antonio, Lavia, Carlo, Dallorto, Laura, Rolle, Teresa, Frezzotti, Paolo, Paoli, Daniela, Salvi, Erika, Manunta, Paolo, Mori, Yosai, Miyata, Kazunori, Higashide, Tomomi, Chihara, Etsuo, Ishiko, Satoshi, Yoshida, Akitoshi, Yanagi, Masahide, Kiuchi, Yoshiaki, Ohashi, Tsutomu, Sakurai, Toshiya, Sugimoto, Takako, Chuman, Hideki, Aihara, Makoto, Inatani, Masaru, Miyake, Masahiro, Gotoh, Norimoto, Matsuda, Fumihiko, Yoshimura, Nagahisa, Ikeda, Yoko, Ueno, Morio, Sotozono, Chie, Jeoung, Jin Wook, Sagong, Min, Park, Kyu Hyung, Ahn, Jeeyun, Cruz Aguilar, Marisa, Ezzouhairi, Sidi M, Rafei, Abderrahman, Chong, Yaan Fun, Ng, Xiao Yu, Goh, Shuang Ru, Chen, Yueming, Yong, Victor H. K, Khan, Muhammad Imran, Olawoye, Olusola O, Ashaye, Adeyinka O, Ugbede, Idakwo, Onakoya, Adeola, Kizor Akaraiwe, Nkiru, Teekhasaenee, Chaiwat, Suwan, Yanin, Supakontanasan, Wasu, Okeke, Suhanya, Uche, Nkechi J, Asimadu, Ifeoma, Ayub, Humaira, Akhtar, Farah, Kosior Jarecka, Ewa, Lukasik, Urszula, Lischinsky, Ignacio, Castro, Vania, Grossmann, Rodolfo Perez, Megevand, Gordana Sunaric, Roy, Sylvain, Dervan, Edward, Silke, Eoin, Rao, Aparna, Sahay, Priti, Fornero, Pablo, Cuello, Osvaldo, Sivori, Delia, Zompa, Tamara, Mills, Richard A, Souzeau, Emmanuelle, Mitchell, Paul, Wang, Jie Jin, Hewitt, Alex W, Coote, Michael, Crowston, Jonathan G, Astakhov, Sergei Y, Akopov, Eugeny L, Emelyanov, Anton, Vysochinskaya, Vera, Kazakbaeva, Gyulli, Fayzrakhmanov, Rinat, Al Obeidan, Saleh A, Owaidhah, Ohoud, Aljasim, Leyla Ali, Chowbay, Balram, Foo, Jia Nee, Soh, Raphael Q, Sim, Kar Seng, Xie, Zhicheng, Cheong, Augustine W. O, Mok, Shi Qi, Soo, Hui Meng, Chen, Xiao Yin, Peh, Su Qin, Heng, Khai Koon, Husain, Rahat, Ho, Su Ling, Hillmer, Axel M, Cheng, Ching Yu, Escudero Domínguez, Francisco A, González Sarmiento, Rogelio, Martinon Torres, Frederico, Salas, Antonio, Pathanapitoon, Kessara, Hansapinyo, Linda, Wanichwecharugruang, Boonsong, Kitnarong, Nari, Sakuntabhai, Anavaj, Nguyn, Hip X, Nguyn, Giang T. T, Nguyn, Trình V, Zenz, Werner, Binder, Alexander, Klobassa, Daniela S, Hibberd, Martin L, Davila, Sonia, Herms, Stefan, Nöthen, Markus M, Moebus, Susanne, Rautenbach, Robyn M, Ziskind, Ari, Carmichael, Trevor R, Ramsay, Michele, Álvarez, Lydia, García, Montserrat, González Iglesias, Héctor, Rodríguez Calvo, Pedro P, Cueto, Luis Fernández Vega, Oguz, Çilingir, Tamcelik, Nevbahar, Atalay, Eray, Batu, Bilge, Aktas, Dilek, Kasım, Burcu, Wilson, M. Roy, Coleman, Anne L, Liu, Yutao, Challa, Pratap, Herndon, Leon, Kuchtey, Rachel W, Kuchtey, John, Curtin, Karen, Chaya, Craig J, Crandall, Alan, Zangwill, Linda M, Wong, Tien Yin, Nakano, Masakazu, Kinoshita, Shigeru, den Hollander, Anneke I, Vesti, Eija, Fingert, John H, Lee, Richard K, Sit, Arthur J, Shingleton, Bradford J, Wang, Ningli, Cusi, Daniele, Qamar, Raheel, Kraft, Peter, Pericak Vance, Margaret A, Raychaudhuri, Soumya, Heegaard, Steffen, Kivelä, Tero, Reis, André, Kruse, Friedrich E, Weinreb, Robert N, Pasquale, Louis R, Haines, Jonathan L, Thorsteinsdottir, Unnur, Jonasson, Fridbert, Allingham, R. Rand, Milea, Dan, Ritch, Robert, Kubota, Toshiaki, Tashiro, Kei, Vithana, Eranga N, Micheal, Shazia, Topouzis, Foti, Craig, Jamie E, Dubina, Michael, Sundaresan, Periasamy, Stefansson, Kari, Wiggs, Janey L, Pasutto, Francesca, Khor, Chiea Chuen, University of Helsinki-University of Helsinki-Faculty of Medecine [Helsinki], University of Helsinki-University of Helsinki, Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris], and University of Helsinki
Subjects: 0301 basic medicine, Male, Calcium Channels/genetics, Messenger, Medizin, PSEUDOEXFOLIATION SYNDROME, Genome-wide association study, BLOOD-PRESSURE, Disease, Exfoliation Syndrome, Eye, Exfoliation Syndrome/ethnology/genetics, Sensory disorders Donders Center for Medical Neuroscience [Radboudumc 12], 0302 clinical medicine, PARKINSONS-DISEASE, 80 and over, ta319, Missense mutation, Genetics, Aged, 80 and over, Amino Acid Oxidoreductases/genetics/physiology, Alleles, Amino Acid Oxidoreductases, Amino Acid Substitution, Asian Continental Ancestry Group, Calcium Channels, Cell Adhesion, Extracellular Matrix, Female, Gene Expression Profiling, Genetic Predisposition to Disease, Haplotypes, Humans, Molecular Chaperones, RNA, Messenger, Spheroids, Cellular, Genome-Wide Association Study, Mutation, Missense, Point Mutation, Metaanalysis, [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], 3. Good health, ALZHEIMERS-DISEASE, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Molecular Chaperones/biosynthesis/genetics, Biology, SYNONYMOUS MUTATIONS, ta3111, Article, 03 medical and health sciences, Asian People, Asian Continental Ancestry Group/genetics, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, Allele, Risk factor, GENOME-WIDE ASSOCIATION, Eye/metabolism, Aged, Genetic association, [SDV.GEN.GPO]Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE], Haplotype, Individuals, Glaucoma, Odds ratio, Extracellular Matrix/metabolism, RNA, Messenger/biosynthesis, MACULAR DEGENERATION, RISK LOCI, eye diseases, COMMON SEQUENCE VARIANTS, 030104 developmental biology, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, Mutation, 030221 ophthalmology & optometry, RNA, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Cellular, Spheroids, Missense, [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM], Polymorphisms, purl.org/pe-repo/ocde/ford#1.06.07 [https], INFLAMMATORY-BOWEL-DISEASE
Abstract: International audience; Exfoliation syndrome (XFS) is the commonest known risk factor for secondary glaucoma and a significant cause of blindness worldwide. Variants in two genes, LOXL1 and CACNA1A have been previously associated with XFS. To further elucidate the genetic basis of XFS, we collected a global sample of XFS cases to refine the association at LOXL1, which previously showed inconsistent results between populations,and to identify new variants associated with XFS. We identified a rare, protective allele at LOXL1 (p.407Phe, OR= 25, P=2.9 x 10-14) through deep resequencing of XFS cases and controls from 9 countries. This variant results in increased cellular adhesion strength compared to the wild-type (p.407Tyr) allele. A genome-wide association study (GWAS) of XFS cases and controls from 24 countries followed by replication in 18 countries identified seven genome-wide significant loci (P < 5 x 10-8). Index variants at the new loci map to chromosomes 13q12 (POMP), 11q23.3 (TMEM136), 6p21 (AGPAT1), 3p24 (RBMS3) and 5q23 (near SEMA6A). These findings provide biological insights into the pathology of XFS, and highlight a potential role for naturally occurring rare LOXL1 variants in disease biology.
Published: 2017

36. Updated Expert Consensus Statement on Platelet Function and Genetic Testing for Guiding P2Y12 Receptor Inhibitor Treatment in Percutaneous Coronary Intervention

Author: Derek So, Franz-Josef Neumann, Naveen L. Pereira, Gregg W. Stone, Lisa Gross, Robert F. Storey, Dietmar Trenk, David J. Moliterno, Jean-Philippe Collet, Marco Valgimigli, Dominick J. Angiolillo, Udaya S. Tantry, Matthew J. Price, Laurent Bonello, Young-Hoon Jeong, Dimitrios Alexopoulos, Francesco Franchi, Paul A. Gurbel, Roxana Mehran, Daniel Aradi, Deepak L. Bhatt, Thomas Cuisset, Dirk Sibbing, Jurriën M. ten Berg, Ron Waksman, Marc S. Sabatine, Ludwig-Maximilians-Universität München (LMU), Semmelweis University [Budapest], University of Athens Medical School [Athens], St. Antonius Hospital [Nieuwegein], VA Boston Healthcare System, Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut de cardiologie [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), University of North Florida [Jacksonville] (UNF), Gyeongsang National University, Icahn School of Medicine at Mount Sinai [New York] (MSSM), University of Kentucky, University Hospital Freiburg, Mayo Clinic, Scripps Clinic [San Diego, CA, USA], Harvard Medical School [Boston] (HMS), University of Ottawa [Ottawa], Columbia University [New York], University of Sheffield [Sheffield], Mount Sinai Hospital [Toronto, Canada] (MSH), University of Bern, Washington University School of Medicine in St. Louis, Washington University in Saint Louis (WUSTL), University of Florida [Gainesville] (UF), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), and University of Kentucky (UK)
Subjects: medicine.medical_specialty, Acute coronary syndrome, OF-FUNCTION POLYMORPHISM, Prasugrel, medicine.medical_treatment, [SDV]Life Sciences [q-bio], GUIDED ANTIPLATELET THERAPY, 030204 cardiovascular system & hematology, Coronary artery disease, 03 medical and health sciences, 0302 clinical medicine, PATIENTS SHOWING RESISTANCE, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, ASPIRIN AND/OR RESISTANCE, CLOPIDOGREL-TREATED PATIENTS, DUAL ANTIPLATELET, STENT THROMBOSIS, medicine, 030212 general & internal medicine, Intensive care medicine, thrombosis, business.industry, Standard treatment, P2Y(12) receptor inhibitor, ELEVATION MYOCARDIAL-INFARCTION, Percutaneous coronary intervention, BYPASS GRAFT-SURGERY, Guideline, Clopidogrel, medicine.disease, 3. Good health, genotyping, CYP2C19 GENOTYPE, Cardiology and Cardiovascular Medicine, business, Ticagrelor, platelet function testing, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, medicine.drug
Abstract: International audience; Dual-antiplatelet therapy (DAPT) with aspirin and a P2Y(12) receptor inhibitor is the standard treatment for patients undergoing percutaneous coronary intervention. The availability of different P2Y(12) receptor inhibitors (clopidogrel, prasugrel, ticagrelor) with varying levels of potency has enabled physicians to contemplate individualized treatment regimens, which may include escalation or de-escalation of P2Y(12)-inhibiting therapy. Indeed, individualized and alternative DAPT strategies may be chosen according to the clinical setting (stable coronary artery disease vs. acute coronary syndrome), the stage of the disease (early-vs. long-term treatment), and patient risk for ischemic and bleeding complications. A tailored DAPT approach may be potentially guided by platelet function testing (PFT) or genetic testing. Although the routine use of PFT or genetic testing in percutaneous coronary intervention-treated patients is not recommended, recent data have led to an update in guideline recommendations that allow considering selective use of PFT for DAPT de-escalation. However, guidelines do not expand on when to implement the selective use of such assays into decision making for personalized treatment approaches. Therefore, an international expert consensus group of key leaders from North America, Asia, and Europe with expertise in the field of antiplatelet treatment was convened. This document updates 2 prior consensus papers on this topic and summarizes the contemporary updated expert consensus recommendations for the selective use of PFT or genotyping in patients undergoing percutaneous coronary intervention. (c) 2019 by the American College of Cardiology Foundation.
Published: 2019

37. Molecular evolutionary trends and feeding ecology diversification in the Hemiptera, anchored by the milkweed bug genome

Author: Shwetha C. Murali, Hsiao-ling Lu, Siegfried Roth, Huyen Dinh, Peter K. Dearden, Barbara M. I. Vreede, M. Emília Santos, Evgeny M. Zdobnov, Viera Kovacova, Christopher J. Holmes, Stefano Colella, Yuichiro Suzuki, Tamsin E. M. Jones, Chun-che Chang, Stefan Koelzer, Jeffery W. Jones, Essia Sghaier, Thorsten Horn, Richard A. Gibbs, Mackenzie Lovegrove, Panagiotis Ioannidis, Lucila Traverso, Subba Reddy Palli, Megan L. Porter, Olivia Tidswell, Peter Nagui Refki, Neta Ginzburg, Rolando Rivera-Pomar, Sandra L. Lee, Chris Jacobs, Cassandra G. Extavour, Jan Seibert, Amanda Dolan, David Armisén, Jayendra Nath Shukla, Kristen A. Panfilio, Christopher P. Childers, Matthew T. Weirauch, Daniel S.T. Hughes, Jiaxin Qu, Kim C. Worley, Hugh M. Robertson, Monica Munoz-Torres, Markus Friedrich, Emily C. Jennings, Elizabeth J. Duncan, Andrew G. Cridge, Hsu Chao, J. Spencer Johnston, Maurijn van der Zee, Mei-Ju May Chen, John H. Werren, Abderrahman Khila, Shannon Dugan, Stephen Richards, Lena Sachs, Joshua B. Benoit, Antonin J.J. Crumière, Nicolas Parisot, Megan Leask, Yen-Ta Chen, Harshavardhan Doddapaneni, Gérard Febvay, Donna M. Muzny, Ariel D. Chipman, Rose Richter, Robert M. Waterhouse, Leslie Pick, Monica F. Poelchau, Patricia J. Moore, Chloé Suzanne Berger, Richard J. Stancliffe, Yi Min Hsiao, Séverine Viala, Chien-Yueh Lee, Yi Han, Iris M. Vargas Jentzsch, Elise M. Didion, Deniz F. Erezyilmaz, Yong Lu, Andrew J. Rosendale, Peter Heger, Patrice Baa-Puyoulet, Biologie Fonctionnelle, Insectes et Interactions (BF2I), Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut National de la Recherche Agronomique (INRA)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA), University of Illinois [Chicago] (UIC), University of Illinois System, Department of Biology, Georgetown University, Université de Lausanne (UNIL), Cincinnati Children's Hospital Medical Center, Biochemistry Department, University of Otago [Dunedin, Nouvelle-Zélande], Human Genome Sequencing Center, Baylor College of Medicine, Baylor College of Medicine (BCM), Baylor University-Baylor University, University of Edinburgh, Lawrence Berkeley National Laboratory [Berkeley] (LBNL), Department of Entomology [Lexington], University of Kentucky, Cologne Biocenter, Institute of Developmental Biology, Institute of Developmental Biology, University of Basel (Unibas), Institut de Génomique Fonctionnelle de Lyon (IGFL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Recherche Agronomique (INRA)-École normale supérieure - Lyon (ENS Lyon), Human Genome Sequencing Center [Houston] (HGSC), Department of Genetic Medicine and Development [Geneva], Université de Genève (UNIGE), United States Department of Health & Human Services National Institutes of Health (NIH) - USA [U54 HG003273], German Research Foundation (DFG) [PA 2044/1 1 SFB 680], Swiss National Science Foundation (SNSF) [31003A_143936, PP00P3_170664], European Research Council grant ERC-CoG [616346], German Research Foundation (DFG) [SFB 680], National Science Foundation (NSF) [US NSF DEB1257053], United States Department of Health & Human Services National Institutes of Health (NIH) - USA [5R01GM080203, 5R01HG004483, R01GM113230], United States Department of Energy (DOE) [DE-AC02-05CH11231], École normale supérieure - Lyon (ENS Lyon)-Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Georgetown University [Washington] (GU), Université de Lausanne = University of Lausanne (UNIL), University of Kentucky (UK), École normale supérieure de Lyon (ENS de Lyon)-Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Genève = University of Geneva (UNIGE), Panfilio, Kristen A [0000-0002-6417-251X], Vargas Jentzsch, Iris M [0000-0003-4527-1560], Benoit, Joshua B [0000-0002-4018-3513], Erezyilmaz, Deniz [0000-0001-8416-8561], Suzuki, Yuichiro [0000-0002-0957-3564], Colella, Stefano [0000-0003-3139-6055], Poelchau, Monica F [0000-0002-4584-6056], Waterhouse, Robert M [0000-0003-4199-9052], Ioannidis, Panagiotis [0000-0003-0939-6745], Weirauch, Matthew T [0000-0001-7977-9122], Werren, John H [0000-0001-9353-2070], Jacobs, Chris GC [0000-0002-3128-2288], Duncan, Elizabeth J [0000-0002-1841-504X], Vreede, Barbara MI [0000-0002-5023-4601], Chang, Chun-Che [0000-0002-3586-1607], Chen, Mei-Ju M [0000-0001-7768-8905], Chen, Yen-Ta [0000-0002-4570-6061], Childers, Christopher P [0000-0002-1253-5550], Chipman, Ariel D [0000-0001-6696-840X], Cridge, Andrew G [0000-0002-1399-5188], Crumière, Antonin JJ [0000-0003-2214-2993], Dearden, Peter K [0000-0001-7790-9675], Didion, Elise M [0000-0002-4987-8901], Dinh, Huyen [0000-0003-0336-0362], Doddapaneni, Harsha Vardhan [0000-0002-2433-633X], Dugan, Shannon [0000-0003-1482-816X], Extavour, Cassandra G [0000-0003-2922-5855], Febvay, Gérard [0000-0002-0654-2340], Friedrich, Markus [0000-0002-5622-7920], Han, Yi [0000-0001-7605-8979], Holmes, Christopher J [0000-0001-9612-366X], Horn, Thorsten [0000-0001-8181-939X], Hsiao, Yi-Min [0000-0002-1817-0302], Jennings, Emily C [0000-0002-7687-5319], Johnston, J Spencer [0000-0003-4792-2945], Jones, Tamsin E [0000-0002-0027-0858], Khila, Abderrahman [0000-0003-0908-483X], Kovacova, Viera [0000-0003-4581-4254], Lee, Chien-Yueh [0000-0002-4304-974X], Lu, Hsiao-Ling [0000-0002-4029-6470], Moore, Patricia J [0000-0001-9802-7217], Munoz-Torres, Monica C [0000-0001-8430-6039], Muzny, Donna M [0000-0002-3055-0359], Palli, Subba R [0000-0002-0873-3247], Parisot, Nicolas [0000-0001-5217-8415], Pick, Leslie [0000-0002-4505-5107], Porter, Megan L [0000-0001-7985-2887], Qu, Jiaxin [0000-0002-1122-9391], Rivera-Pomar, Rolando [0000-0002-7720-7064], Rosendale, Andrew J [0000-0002-2463-8856], Roth, Siegfried [0000-0001-5772-3558], Shukla, Jayendra N [0000-0003-1589-1929], Stancliffe, Richard J [0000-0002-6972-9655], van der Zee, Maurijn [0000-0002-8728-8646], Worley, Kim C [0000-0002-0282-1000], Richards, Stephen [0000-0001-8959-5466], and Apollo - University of Cambridge Repository
Subjects: gene family evolution, Lineage (evolution), [SDV]Life Sciences [q-bio], Genome, Insect, Gene Transfer, Gene Dosage, Insect, Genome, purl.org/becyt/ford/1 [https], 0302 clinical medicine, CYS2-HIS2 Zinc Fingers, phytophagy, ddc:576.5, lcsh:QH301-705.5, media_common, [SDV.EE]Life Sciences [q-bio]/Ecology, environment, 0303 health sciences, biology, Large milkweed bug, Ecology, Pigmentation, [SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE], Genes, Homeobox, Biological Sciences, Lygaeidae, Hemiptera, séquence du génome, Smell, evolution of development, TRANSCRIPTION FACTORS, puceron, Biotechnology, lcsh:QH426-470, Gene Transfer, Horizontal, ddc:025.063/570, Evolution, Bioinformatics, media_common.quotation_subject, 1.1 Normal biological development and functioning, Transcription Factors/genetics, Zoology, Amino Acid Sequence, Animals, Evolution, Molecular, Feeding Behavior, Gene Expression Profiling, Hemiptera/genetics, Hemiptera/growth & development, Hemiptera/metabolism, Pigmentation/genetics, Evolution of development, Gene family evolution, Gene structure, Lateral gene transfer, Phytophagy, RNAi, Transcription factors, GENE FAMILY EVOLUTION, Genomics, Biotechnologies, LATERAL GENE TRANSFER, Horizontal, 03 medical and health sciences, Molecular evolution, Underpinning research, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], Information and Computing Sciences, transcription factors, RNAI, Genetics, Homeobox, GENE STRUCTURE, purl.org/becyt/ford/1.6 [https], SB, Genome size, Ciencias Exactas, 030304 developmental biology, Whole genome sequencing, QL, QH, Research, gene structure, lateral gene transfer, Human Genome, fungi, Molecular, biology.organism_classification, Hemiptera/genetics/growth & development/metabolism, diversité des populations, lcsh:Genetics, [SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics, PHYTOPHAGY, lcsh:Biology (General), Genes, Animal ecology, Evolutionary biology, EVOLUTION OF DEVELOPMENT, Evolutionary developmental biology, 030217 neurology & neurosurgery, Environmental Sciences
Abstract: Background: The Hemiptera (aphids, cicadas, and true bugs) are a key insect order, with high diversity for feeding ecology and excellent experimental tractability for molecular genetics. Building upon recent sequencing of hemipteran pests such as phloem-feeding aphids and blood-feeding bed bugs, we present the genome sequence and comparative analyses centered on the milkweed bug Oncopeltus fasciatus, a seed feeder of the family Lygaeidae. Results: The 926-Mb Oncopeltus genome is well represented by the current assembly and official gene set. We use our genomic and RNA-seq data not only to characterize the protein-coding gene repertoire and perform isoform-specific RNAi, but also to elucidate patterns of molecular evolution and physiology. We find ongoing, lineage-specific expansion and diversification of repressive C2H2 zinc finger proteins. The discovery of intron gain and turnover specific to the Hemiptera also prompted the evaluation of lineage and genome size as predictors of gene structure evolution. Furthermore, we identify enzymatic gains and losses that correlate with feeding biology, particularly for reductions associated with derived, fluid nutrition feeding. Conclusions: With the milkweed bug, we now have a critical mass of sequenced species for a hemimetabolous insect order and close outgroup to the Holometabola, substantially improving the diversity of insect genomics. We thereby define commonalities among the Hemiptera and delve into how hemipteran genomes reflect distinct feeding ecologies. Given Oncopeltus’s strength as an experimental model, these new sequence resources bolster the foundation for molecular research and highlight technical considerations for the analysis of medium-sized invertebrate genomes., La lista completa de autores puede verse en el archivo asociado., Facultad de Ciencias Exactas, Centro Regional de Estudios Genómicos
Published: 2019

38. Perspectives on ethnic and racial disparities in Alzheimer's disease and related dementias: Update and areas of immediate need

Author: Jennifer J. Manly, Ralph N. Martins, Lon S. Schneider, Kerry Kilborn, Yakeel T. Quiroz, Scott M. Hofer, Robert A. Rissman, Octavio A. Santos, Hiroko H. Dodge, Steven D. Edland, Charlotte E. Teunissen, Ganesh M. Babulal, Hector M. González, Esther S. Oh, Donna M. Wilcock, Debora Melo van Lent, Michael Weinborn, Michelle M. Mielke, Carrie Ciro, Andre Strydom, James Hendrix, Catherine M. Roe, Roos J. Jutten, Graciela Muniz Terrera, Claudio Babiloni, Nicole Schupf, Melissa E. Murray, Benedict C. Albensi, Heather M. Snyder, Gaël Chételat, Gene L. Bowman, Elizabeth Head, Peggye Dilworth-Anderson, Anna J. Esbensen, Simone Dreux, Eider M. Arenaza-Urquijo, Adam M. Brickman, Sid E. O'Bryant, Mario A. Parra, Sietske A.M. Sikkes, Ann D. Cohen, Henrik Zetterberg, Martha Clare Morris, Leigh A. Johnson, Alex Bahar-Fuchs, Linda M.P. Wesselman, Lisbeth Evered, Keith N. Fargo, Joanne Bell, Arlene Astell, Juan Fortea, Michael Ewers, Nikolaos Scarmeas, Krista L. Lanctôt, Yaakov Stern, Hamid R. Sohrabi, Deborah Gustafson, Yi Tang, Washington University School of Medicine in St. Louis, Washington University in Saint Louis (WUSTL), Massachusetts General Hospital [Boston], Harvard Medical School [Boston] (HMS), St. Boniface Hospital Albrechtsen Research Centre [Winnipeg], University of Manitoba [Winnipeg], Mayo Clinic [Rochester], University of Toronto, University of Reading (UOR), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], IRCCS-Hospital San Raffaele Pisana of Rome and Cassino, University of Melbourne, Syneos Health [Wilmington], Nestlé Institute of Health Sciences SA [Lausanne, Switzerland], Oregon Health & Science University [Portland], Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University [New York], Physiopathologie et imagerie des troubles neurologiques (PhIND), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Kansas [Kansas City], University of Pittsburgh School of Medicine, Pennsylvania Commonwealth System of Higher Education (PCSHE), University of North Carolina [Chapel Hill] (UNC), University of North Carolina System (UNC), Harvard College [Cambridge], University of California [San Diego] (UC San Diego), University of California, University of Cincinnati (UC), Cincinnati Children's Hospital Medical Center, Klinikum der Universität [München], Medical & Scientific Relations, Alzheimer's Association [Chicago], Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona (UAB), Fundació Catalana de Síndrome de Down [Barcelona], Psychiatry and neurochemistry, SUNY Downstate Medical Center, State University of New York (SUNY), University of Kentucky, University of Victoria [Canada] (UVIC), University of North Texas Health Science Center [Fort Worth], VU University Medical Center [Amsterdam], University of Glasgow, Edith Cowan University [Joondalup], Rush University [Chicago], Mayo Clinic [Jacksonville], Johns Hopkins University School of Medicine [Baltimore], Department of Psychology [Edinburgh], Heriot-Watt University [Edinburgh] (HWU), Universidad Autonoma del Caribe [Barranquilla], University of Southern California (USC), Mailman School of Public Health Columbia University [New-York], Institute of Psychiatry, Psychology & Neuroscience, King's College London, King‘s College London, Xuan Wu Hospital [Beijing], Capital University of Medical Sciences [Beijing] (CUMS), University of Edinburgh, German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Sahlgrenska University Hospital, University College of London [London] (UCL), University of Gothenburg (GU), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), University of California (UC), University of Kentucky (UK), and Duchange, Nathalie
Subjects: Gerontology, Ethnoracial, Aging, Biomedical Research, epidemiology [Alzheimer Disease], Alzheimer's related dementias, Ethnic group, Disease, Underserved, Neurodegenerative, cellular and molecular neuroscience, 0302 clinical medicine, White paper, Ethnicity, 030212 general & internal medicine, Alzheimer's Association, media_common, neurology (clinical), Diversity, Continental Population Groups, Translational, health policy, Alzheimer's disease, 3. Good health, psychiatry and mental health, epidemiology, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], geriatrics and gerontology, International Society to Advance Alzheimer's Research and Treatment, Alzheimer's Association, Population ageing, media_common.quotation_subject, Clinical Sciences, BF, Ethnic Groups, International Society to Advance Alzheimer's Research and Treatment, Article, Neglect, 03 medical and health sciences, Alzheimer Disease, Political science, medicine, diversity, ethnicity, ethnoracial, translational, underserved, developmental neuroscience, Acquired Cognitive Impairment, Dementia, Humans, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], ddc:610, Healthcare Disparities, Aged, ethnology [Alzheimer Disease], Racial Groups, Neurosciences, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), medicine.disease, Brain Disorders, Geriatrics, 030217 neurology & neurosurgery, Biomarkers, Diversity (politics)
Abstract: Altres ajuts: Fondo Europeo de Desarrollo Regional (FEDER), Unión Europea, "Una manera de hacer Europa", La "Marató TV3" grant (20141210 to J.F.) Alzheimer's disease and related dementias (ADRDs) are a global crisis facing the aging population and society as a whole. With the numbers of people with ADRDs predicted to rise dramatically across the world, the scientific community can no longer neglect the need for research focusing on ADRDs among underrepresented ethnoracial diverse groups. The Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART; alz.org/ISTAART) comprises a number of professional interest areas (PIAs), each focusing on a major scientific area associated with ADRDs. We leverage the expertise of the existing international cadre of ISTAART scientists and experts to synthesize a cross-PIA white paper that provides both a concise "state-of-the-science" report of ethnoracial factors across PIA foci and updated recommendations to address immediate needs to advance ADRD science across ethnoracial populations.
Published: 2019

39. A Comparative Assessment of the Performance of Individual Tree Crowns Delineation Algorithms from ALS Data in Tropical Forests

Author: Aubry-Kientz, M., Dutrieux, R., Ferraz, A., Saatchi, S., Hamraz, H., Williams, J., Coomes, D., Piboule, A., Vincent, Grégoire, Ecologie des forêts de Guyane (UMR ECOFOG), Université des Antilles (UA)-Université de Guyane (UG)-Centre National de la Recherche Scientifique (CNRS)-AgroParisTech-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA), Botanique et Modélisation de l'Architecture des Plantes et des Végétations (UMR AMAP), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de la Recherche Agronomique (INRA)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD [France-Sud]), Jet Propulsion Laboratory (JPL), NASA-California Institute of Technology (CALTECH), California Institute of Technology (CALTECH), University of Kentucky, Department of Plant Sciences (Cambridge, UK), University of Cambridge [UK] (CAM), Office National des Forêts (ONF), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-AgroParisTech-Université de Guyane (UG)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), University of Kentucky (UK), Office national des forêts (ONF), and California Institute of Technology (CALTECH)-NASA
Subjects: tropical forest, benchmark, [SDE.IE]Environmental Sciences/Environmental Engineering, Science, airborne laser scanning, individual tree crown segmentation, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing
Abstract: International audience; Tropical forest canopies are comprised of tree crowns of multiple species varying in shape and height, and ground inventories do not usually reliably describe their structure. Airborne laser scanning data can be used to characterize these individual crowns, but analytical tools developed for boreal or temperate forests may require to be adjusted before they can be applied to tropical environments. Therefore, we compared results from six different segmentation methods applied to six plots (39 ha) from a study site in French Guiana. We measured the overlap of automatically segmented crowns projection with selected crowns manually delineated on high-resolution photography. We also evaluated the goodness of fit following automatic matching with field inventory data using a model linking tree diameter to tree crown width. The different methods tested in this benchmark segmented highly different numbers of crowns having different characteristics. Segmentation methods based on the point cloud (AMS3D and Graph-Cut) globally outperformed methods based on the Canopy Height Models, especially for small crowns; the AMS3D method outperformed the other methods tested for the overlap analysis, and AMS3D and Graph-Cut performed the best for the automatic matching validation. Nevertheless, other methods based on the Canopy Height Model performed better for very large emergent crowns. The dense foliage of tropical moist forests prevents sufficient point densities in the understory to segment subcanopy trees accurately, regardless of the segmentation method.
Published: 2019

40. Unlocking the Capabilities of Future High-Resolution X-ray Spectroscopy Missions Through Laboratory Astrophysics

Author: Betancourt-Martinez, Gabriele, Akamatsu, Hiroki, Barret, Didier, Bautista, Manuel, Bernitt, Sven, Bianchi, Stefano, Bodewits, Dennis, Brickhouse, Nancy, Brown, Gregory V., Costantini, Elisa, Coreno, Marcello, López-Urrutia, José R. Crespo, Cumbee, Renata, Eckart, Megan, Ferland, Gary, Fiore, Fabrizio, Fogle, Michael, Foster, Adam, Garcia, Javier, Gorczyca, Tom, Grinberg, Victoria, Grosso, Nicolas, Gu, Liyi, Gu, Ming Feng, Guainazzi, Matteo, Hell, Natalie, Herder, Jan-Willem Den, Kaastra, Jelle, Kallman, Timothy, Lee, Julia, Leutenegger, Maurice, Marler, Joan, Mccammon, Dan, Nakashima, Shinya, Nicastro, Fabrizio, Paerels, Frits, Pajot, François, Pointecouteau, Etienne, Porquet, Delphine, Porter, F. Scott, Savin, Daniel Wolf, Sawada, Makoto, Shah, Chintan, Simionescu, Aurora, de Simone, Monica, Sosolik, Chad, Stancil, Phillip, Steinbrügge, René, Yamaguchi, Hiroya, Institut de recherche en astrophysique et planétologie (IRAP), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), SRON Netherlands Institute for Space Research (SRON), Friedrich-Schiller-Universität = Friedrich Schiller University Jena [Jena, Germany], Università degli Studi Roma Tre = Roma Tre University (ROMA TRE), Auburn University (AU), Lawrence Livermore National Laboratory (LLNL), Max-Planck-Institut für Kernphysik (MPIK), Max-Planck-Gesellschaft, NASA Goddard Space Flight Center (GSFC), University of Kentucky (UK), Istituto Nazionale di Astrofisica (INAF), California Institute of Technology (CALTECH), Eberhard Karls Universität Tübingen = Eberhard Karls University of Tuebingen, Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Space Sciences Laboratory [Berkeley] (SSL), University of California [Berkeley] (UC Berkeley), University of California (UC)-University of California (UC), Agence Spatiale Européenne = European Space Agency (ESA), University of Wisconsin-Madison, Columbia University [New York], Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Clemson University, University of Georgia [USA], Deutsches Elektronen-Synchrotron [Hamburg] (DESY), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Università degli Studi Roma Tre, University of Kentucky, Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Centre National d'Études Spatiales [Toulouse] (CNES), University of California [Berkeley], University of California-University of California, Agence Spatiale Européenne (ESA), European Space Agency (ESA), and Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)
Subjects: High Energy Astrophysical Phenomena (astro-ph.HE), [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], [SDU.ASTR.HE]Sciences of the Universe [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], Astrophysics of Galaxies (astro-ph.GA), Astrophysics::Instrumentation and Methods for Astrophysics, FOS: Physical sciences, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Astrophysics of Galaxies
Abstract: Thanks to high-resolution and non-dispersive spectrometers onboard future X-ray missions such as XRISM and Athena, we are finally poised to answer important questions about the formation and evolution of galaxies and large-scale structure. However, we currently lack an adequate understanding of many atomic processes behind the spectral features we will soon observe. Large error bars on parameters as critical as transition energies and atomic cross sections can lead to unacceptable uncertainties in the calculations of e.g., elemental abundance, velocity, and temperature. Unless we address these issues, we risk limiting the full scientific potential of these missions. Laboratory astrophysics, which comprises theoretical and experimental studies of the underlying physics behind observable astrophysical processes, is therefore central to the success of these missions., Comment: Science white paper submitted to the Astro2020 Decadal Survey
Published: 2019
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41. Conserved and specific genomic features of endogenous polydnaviruses revealed by whole genome sequencing of two ichneumonid wasps

Author: Claire Lemaitre, Seán G. Brady, Fabrice Legeai, Stéphanie Robin, Denis Tagu, Bernardo F. Santos, Shanlin Liu, Véronique Jouan, Anthony Bretaudeau, Anne-Nathalie Volkoff, Xin Zhou, Marc Ravallec, Rebecca B. Dikow, Gabor Gyapay, Jean-Michel Drezen, Bruce A. Webb, Institut de Génétique, Environnement et Protection des Plantes (IGEPP), Institut National de la Recherche Agronomique (INRA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-AGROCAMPUS OUEST, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES), National Museum for Natural History, Smithsonian Institution, Diversité, Génomes & Interactions Microorganismes - Insectes [Montpellier] (DGIMI), Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de la Recherche Agronomique (INRA), Université de Tours, Institut de Génomique d'Evry (IG), Institut de Biologie François JACOB (JACOB), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Department of Entomology, China Agricultural University (CAU), China National GeneBank, University of Kentucky, Institut National de la Recherche Agronomique (INRA)-Université de Rennes (UR)-AGROCAMPUS OUEST, Université de Rennes (UR), Institut National de la Recherche Agronomique (INRA)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université de Montpellier (UM), Université de Tours (UT), Université Paris-Saclay-Institut de Biologie François JACOB (JACOB), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), and University of Kentucky (UK)
Subjects: 0106 biological sciences, food.ingredient, ichnovirus, Virulence, macromolecular substances, Biology, 010603 evolutionary biology, 01 natural sciences, Genome, endogenous virusarchitecture, Parasitoid, 03 medical and health sciences, food, virus domestication, Gene, 030304 developmental biology, Genomic organization, Whole genome sequencing, 0303 health sciences, fungi, biology.organism_classification, Evolutionary biology, Ichnovirus, polydnavirus, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, Bracovirus, parasitoid wasp
Abstract: Polydnaviruses (PDVs) are mutualistic endogenous viruses associated with some lineages of parasitoid wasps that allow successful development of the wasps within their hosts. PDVs include two taxa resulting from independent virus acquisitions in braconid (bracoviruses) and ichneumonid wasps (ichnoviruses). PDV genomes are fully incorporated into the wasp genomes and comprise (1) virulence genes located on proviral segments that are packaged into the viral particle, and (2) genes involved in the production of the viral particles, which are not encapsidated. Whereas the genomic organization of bracoviruses within the wasp genome is relatively well known, the architecture of endogenous ichnoviruses remains poorly understood. We sequenced the genome of two ichnovirus-carrying wasp species,Hyposoter didymatorandCampoletis sonorensis. Complete assemblies with long scaffold sizes allowed identification of the integrated ichnovirus, highlighting an extreme dispersion within the wasp genomes of the viral loci,i.e.isolated proviral segments and clusters of replication genes. Comparing the two wasp species, proviral segments harbor distinct gene content and variable genomic environment, whereas viral machinery clusters show conserved gene content and order, and can be inserted in collinear wasp genomic regions. This distinct architecture is consistent with the biological properties of the two viral elements: proviral segments producing virulence proteins allowing parasitism success are fine-tuned to the host physiology, while an ancestral viral architecture was likely maintained for the genes involved in virus particle production. Finding a distinct genomic architecture of ichnoviruses and bracoviruses highlights different evolutionary trajectories leading to virus domestication in the two wasp lineages.
Published: 2019

42. Mechanisms underlying resilience in ageing

Author: Marc Cantillon, Allyson C. Rosen, Corinne Pettigrew, Yen Ying Lim, Brian T. Gold, Ainara Estanga, Gaël Chételat, Yaakov Stern, Sean A. P. Clouston, Ozioma C. Okonkwo, Silvia Morbelli, Nikolaos Scarmeas, Pablo Martinez-Lage, Christian G. Habeck, Anna C. van Loenhoud, Michael Valenzuela, Rik Ossenkoppele, Chinedu T. Udeh-Momoh, Eider M. Arenaza-Urquijo, Richard N. Jones, Jeremy A. Elman, David Bartrés-Faz, Prashanthi Vemuri, Anja Soldan, Eero Vuoksimaa, Gerd Kempermann, CHETELAT, Gaëlle, Columbia University [New York], Physiopathologie et imagerie des troubles neurologiques (PhIND), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Normandie Université (NU), Mayo Clinic [Rochester], Departament de Psiquiatria i Psicobiologia Clinica, Universitat de Barcelona (UB), Rutgers Robert Wood Johnson Medical School [New Brunswick, NJ, USA] (Rutgers-New Brunswick), Stony Brook University [SUNY] (SBU), State University of New York (SUNY), University of California [San Diego] (UC San Diego), University of California (UC), University of Kentucky (UK), College of Engineering and Computer Science, Australian National University (ANU), German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Florey Institute of Neuroscience and Mental Health [Melbourne, Victoria, Australia], VU University Medical Center [Amsterdam], Fundación Alzheimer Centre Educational, IRCCS Ospedale Policlinico San Martino [Genoa, Italy], University of Wisconsin-Madison, Johns Hopkins University School of Medicine [Baltimore], Stanford University, National and Kapodistrian University of Athens (NKUA), Imperial College London, The University of Sydney, Helsingin yliopisto = Helsingfors universitet = University of Helsinki, University of California, University of Kentucky, and University of Helsinki
Subjects: [SDV]Life Sciences [q-bio], Cognitive Neuroscience, Cognitive neuroscience, Healthy Aging, 03 medical and health sciences, 0302 clinical medicine, ddc:570, Adaptation, Psychological, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Healthy aging, Adaptation, Resilience (network), Brain aging, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, Defense Mechanisms, 0303 health sciences, Resilience, General Neuroscience, Resilience, Psychological, [SDV] Life Sciences [q-bio], Ageing, Psychological, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Cognitive ageing, Psychology, 030217 neurology & neurosurgery, Cognitive psychology
Abstract: International audience; No abstract available
Published: 2019

43. Some combinatorial identities appearing in the calculation of the cohomology of Siegel modular varieties

Author: Richard Ehrenborg, Margaret Readdy, Sophie Morel, Department of Mathematics (Kentucky), University of Kentucky (UK), Unité de Mathématiques Pures et Appliquées (UMPA-ENSL), École normale supérieure de Lyon (ENS de Lyon)-Centre National de la Recherche Scientifique (CNRS), University of Kentucky, and École normale supérieure - Lyon (ENS Lyon)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Pure mathematics, Averaged discrete series characters, Computation, 01 natural sciences, Representation theory, 010104 statistics & probability, shellability, Intersection homology, Symmetric group, [MATH.MATH-CO]Mathematics [math]/Combinatorics [math.CO], FOS: Mathematics, Mathematics - Combinatorics, Discrete Mathematics and Combinatorics, Rank (graph theory), intersection cohomology, Representation Theory (math.RT), 0101 mathematics, Mathematics, Permutohedron, Primary 14G35, 05E45, Secondary 14F43, 05A18, 06A07, 06A11, 52B22, 010102 general mathematics, 16. Peace & justice, Cohomology, Coxeter complex, permutahedron, ordered set partitions, Combinatorics (math.CO), Mathematics - Representation Theory
Abstract: In the computation of the intersection cohomology of Shimura varieties, or of the $L^2$ cohomology of equal rank locally symmetric spaces, combinatorial identities involving averaged discrete series characters of real reductive groups play a large technical role. These identities can become very complicated and are not always well-understood (see for example the appendix of [8]). We propose a geometric approach to these identities in the case of Siegel modular varieties using the combinatorial properties of the Coxeter complex of the symmetric group. Apart from some introductory remarks about the origin of the identities, our paper is entirely combinatorial and does not require any knowledge of Shimura varieties or of representation theory., Comment: 17 pages, 1 figure; to appear in Algebraic Combinatorics
Published: 2019

44. Multilayer bimineralic models for Southern Highlands magnetic anomalies on Mars:Insights from peridotitic laterites in New Caledonia

Author: Ferré, Eric, Ravat, Dhananjay, Clark, David, Launay, Nicolas, Quesnel, Yoann, University of Kentucky (UK), Australian National University (ANU), Centre européen de recherche et d'enseignement des géosciences de l'environnement (CEREGE), and Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
Subjects: [SDU.STU.PL]Sciences of the Universe [physics]/Earth Sciences/Planetology, [SDU.STU.GP]Sciences of the Universe [physics]/Earth Sciences/Geophysics [physics.geo-ph]
Abstract: International audience; Previous models built to explain the large amplitude Southern Highlands magnetic anomalies on Mars involve uniformly magnetized bodies and a single mineral origin. Common sources proposed to account for such large anomalies include mafic dikes, hematite deposits, serpentinized peridotites or layered mafic intrusions. In these models, the main magnetization component arises from the remanence of phases such as single domain magnetite, multi-domain hematite, or hemo-ilmenite.Previous numerical simulations overlooked important aspects of the Mars early history. First, the Martian anomalies occur primarily in the Southern Highlands, where the magnetized crust is Noachian. A lot of information for previous models was derived SNC meteorites extracted from a much younger crust and is therefore probably not relevant. Second, many models consider chiefly anhydrous rock types as potential sources, yet growing evidence suggest not only the presence of liquid water in Noachian times but furthermore indicate abundance of water. Third, while the presence of unaltered olivine at the surface has been interpreted as evidence for lack of water, this inference is incorrect because fresh olivine exists at the surface of Earth. The presence of olivine rather indicates the existence of peridotitic source rocks at the exposure level. Fourth, the Southern Highlands magnetic anomalies are linear, broad, extensive and of large amplitude, although their linear shapes may arise from coalescence of stringed non-linear anomalies.We propose a series of magnetic models built on an upper regolith layer of laterites produced by alteration of serpentinized harzburgites. These models are dominated by hematite in the upper layer and magnetite in the lower one. The magnetic characteristics of the materials involved are derived from those of thick terrestrial laterite deposits in New Caledonia.An alternative hypothesis involves belts of ultramafic volcanic rocks, similar with komatiites (greenstone belts) that are quite common in Archean terrains on Earth. Yet, this model does not seem viable because ultramafic lavas typically have a low viscosity, resulting in the formation of high aspect ratio (thin) flows, hence this type of source would not form thick peridotitic bodies unlike terrestrial ophiolites.
Published: 2018

45. Environmentally Mediated Social Dilemmas

Author: Florence Débarre, Eric Libby, Jorge Peña, Maxime Deforet, Michael E. Hochberg, Sam P. Brown, Jeremy Van Cleve, William R. Harcombe, Sylvie Estrela, Yale University [New Haven], Santa Fe Institute, Umeå University, University of Kentucky, Institut d'écologie et des sciences de l'environnement de Paris (iEES Paris), Institut National de la Recherche Agronomique (INRA)-Sorbonne Université (SU)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Jean Perrin (LJP), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie Paris Seine (IBPS), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), University of Minnesota System, Institute for Advanced Study in Toulouse (IAST), Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées, Georgia Institute of Technology [Atlanta], Institut des Sciences de l'Evolution de Montpellier (UMR ISEM), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS), Agence Nationale de la Recherche (ANR) [14-ACHN-0003], ANR-Labex Institute for Advanced Study in Toulouse (IAST), McDonnell Foundation [220020294], Institut d'écologie et des sciences de l'environnement de Paris (IEES (UMR_7618 / UMR_D_242 / UMR_A_1392 / UM_113) ), Institut de Recherche sur les Phénomènes Hors Equilibre (IRPHE), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École pratique des hautes études (EPHE)-Université de Montpellier (UM)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS), University of Kentucky (UK), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École Pratique des Hautes Études (EPHE), Institut National de la Recherche Agronomique (INRA), Sorbonne Universités (COMUE), Department of Ecology, Evolution, and Behavior, University of Minnesota [Twin Cities] (UMN), University of Minnesota System-University of Minnesota System, Université de Montpellier (UM), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Centre National de la Recherche Scientifique (CNRS)-Institut de recherche pour le développement [IRD] : UR226, Department of Biology, and University of Florida [Gainesville] (UF)
Subjects: 0106 biological sciences, 0301 basic medicine, [SDV]Life Sciences [q-bio], cooperation, Environment, 010603 evolutionary biology, 01 natural sciences, Environmental resource, 03 medical and health sciences, Animals, kin selection, experimental evolution, Social Behavior, dispersal, B- ECONOMIE ET FINANCE, Ecosystem, Ecology, Evolution, Behavior and Systematics, Organism, ComputingMilieux_MISCELLANEOUS, [SDV.GEN.GPO]Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE], Spatial structure, [SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE], Environmental ethics, social, Social dilemma, dynamics, pulbic-goods, spatial structure, populations, Biological Evolution, Invertebrates, Niche construction, evolution niche, 030104 developmental biology, Harm, altruism, Vertebrates, [SDE]Environmental Sciences, structure ecology, Business, construction microbes dispersal spatial, Social evolution, competition, Social behavior, [SDV.EE.IEO]Life Sciences [q-bio]/Ecology, environment/Symbiosis
Abstract: Organisms modify their environments in ways that can be beneficial or detrimental not only to themselves but also to others sharing the same environment. Such niche-constructing or niche-destroying activities are often due to the production or consumption of environmental factors, such as resources, wastes, or toxins, which ultimately influence the ecology and evolution of social interactions. We present a new, four-way classification of social behaviors where individual behaviors are categorized into producing/consuming an environmental factor, as well as into helping/harming others. Although not immediately obvious, dispersal (the act of moving within a habitat or between habitats) is another mechanism by which organisms modify their environment. An explicit representation of such environmentally mediated interactions is key to capturing realistic system complexity and can reveal some unexpected outcomes in social dilemmas.
Published: 2018

46. Analysis of shared heritability in common disorders of the brain

Author: Brainstorm Consortium, Anttila, Verneri, Bulik-Sullivan, Brendan, Finucane, Hilary K, Walters, Raymond K, Bras, Jose, Duncan, Laramie, Escott-Price, Valentina, Falcone, Guido J, Gormley, Padhraig, Malik, Rainer, Patsopoulos, Nikolaos A, Ripke, Stephan, Wei, Zhi, Yu, Dongmei, Lee, Phil H, Turley, Patrick, Grenier-Boley, Benjamin, Chouraki, Vincent, Kamatani, Yoichiro, Berr, Claudine, Letenneur, Luc, Hannequin, Didier, Amouyel, Philippe, Boland, Anne, Deleuze, Jean-François, Duron, Emmanuelle, Vardarajan, Badri N, Reitz, Christiane, Goate, Alison M, Huentelman, Matthew J, Kamboh, M Ilyas, Larson, Eric B, Rogaeva, Ekaterina, St George-Hyslop, Peter, Hakonarson, Hakon, Kukull, Walter A, Farrer, Lindsay A, Barnes, Lisa L, Beach, Thomas G, Demirci, F Yesim, Head, Elizabeth, Hulette, Christine M, Jicha, Gregory A, Kauwe, John SK, Kaye, Jeffrey A, Leverenz, James B, Levey, Allan I, Lieberman, Andrew P, Pankratz, Vernon S, Poon, Wayne W, Quinn, Joseph F, Saykin, Andrew J, Schneider, Lon S, Smith, Amanda G, Sonnen, Joshua A, Stern, Robert A, Van Deerlin, Vivianna M, Van Eldik, Linda J, Harold, Denise, Russo, Giancarlo, Rubinsztein, David C, Bayer, Anthony, Tsolaki, Magda, Proitsi, Petra, Fox, Nick C, Hampel, Harald, Owen, Michael J, Mead, Simon, Passmore, Peter, Morgan, Kevin, Nöthen, Markus M, Rossor, Martin, Lupton, Michelle K, Hoffmann, Per, Kornhuber, Johannes, Lawlor, Brian, McQuillin, Andrew, Al-Chalabi, Ammar, Bis, Joshua C, Ruiz, Agustin, Boada, Mercè, Seshadri, Sudha, Beiser, Alexa, Rice, Kenneth, Van Der Lee, Sven J, De Jager, Philip L, Geschwind, Daniel H, Riemenschneider, Matthias, Riedel-Heller, Steffi, Rotter, Jerome I, Ransmayr, Gerhard, Hyman, Bradley T, Cruchaga, Carlos, Alegret, Montserrat, Winsvold, Bendik, Palta, Priit, Farh, Kai-How, Cuenca-Leon, Ester, Furlotte, Nicholas, Kurth, Tobias, Ligthart, Lannie, Terwindt, Gisela M, Freilinger, Tobias, Ran, Caroline, Gordon, Scott D, Borck, Guntram, Adams, Hieab HH, Lehtimäki, Terho, Wedenoja, Juho, Buring, Julie E, Schürks, Markus, Hrafnsdottir, Maria, Hottenga, Jouke-Jan, Penninx, Brenda, Artto, Ville, Kaunisto, Mari, Vepsäläinen, Salli, Martin, Nicholas G, Montgomery, Grant W, Kurki, Mitja I, Hämäläinen, Eija, Huang, Hailiang, Huang, Jie, Sandor, Cynthia, Webber, Caleb, Muller-Myhsok, Bertram, Schreiber, Stefan, Salomaa, Veikko, Loehrer, Elizabeth, Göbel, Hartmut, Macaya, Alfons, Pozo-Rosich, Patricia, Hansen, Thomas, Werge, Thomas, Kaprio, Jaakko, Metspalu, Andres, Kubisch, Christian, Ferrari, Michel D, Belin, Andrea C, Van Den Maagdenberg, Arn MJM, Zwart, John-Anker, Boomsma, Dorret, Eriksson, Nicholas, Olesen, Jes, Chasman, Daniel I, Nyholt, Dale R, Avbersek, Andreja, Baum, Larry, Berkovic, Samuel, Bradfield, Jonathan, Buono, Russell J, Catarino, Claudia B, Cossette, Patrick, De Jonghe, Peter, Depondt, Chantal, Dlugos, Dennis, Ferraro, Thomas N, French, Jacqueline, Hjalgrim, Helle, Jamnadas-Khoda, Jennifer, Kälviäinen, Reetta, Kunz, Wolfram S, Lerche, Holger, Leu, Costin, Lindhout, Dick, Lo, Warren, Lowenstein, Daniel, McCormack, Mark, Møller, Rikke S, Molloy, Anne, Ng, Ping-Wing, Oliver, Karen, Privitera, Michael, Radtke, Rodney, Ruppert, Ann-Kathrin, Sander, Thomas, Schachter, Steven, Schankin, Christoph, Scheffer, Ingrid, Schoch, Susanne, Sisodiya, Sanjay M, Smith, Philip, Sperling, Michael, Striano, Pasquale, Surges, Rainer, Thomas, G Neil, Visscher, Frank, Whelan, Christopher D, Zara, Federico, Heinzen, Erin L, Marson, Anthony, Becker, Felicitas, Stroink, Hans, Zimprich, Fritz, Gasser, Thomas, Gibbs, Raphael, Heutink, Peter, Martinez, Maria, Morris, Huw R, Sharma, Manu, Ryten, Mina, Mok, Kin Y, Pulit, Sara, Bevan, Steve, Holliday, Elizabeth, Attia, John, Battey, Thomas, Boncoraglio, Giorgio, Thijs, Vincent, Chen, Wei-Min, Mitchell, Braxton, Rothwell, Peter, Sharma, Pankaj, Sudlow, Cathie, Vicente, Astrid, Markus, Hugh, Kourkoulis, Christina, Pera, Joana, Raffeld, Miriam, Silliman, Scott, Boraska Perica, Vesna, Thornton, Laura M, Huckins, Laura M, William Rayner, N, Lewis, Cathryn M, Gratacos, Monica, Rybakowski, Filip, Keski-Rahkonen, Anna, Raevuori, Anu, Hudson, James I, Reichborn-Kjennerud, Ted, Monteleone, Palmiero, Karwautz, Andreas, Mannik, Katrin, Baker, Jessica H, O'Toole, Julie K, Trace, Sara E, Davis, Oliver SP, Helder, Sietske G, Ehrlich, Stefan, Herpertz-Dahlmann, Beate, Danner, Unna N, Van Elburg, Annemarie A, Clementi, Maurizio, Forzan, Monica, Docampo, Elisa, Lissowska, Jolanta, Hauser, Joanna, Tortorella, Alfonso, Maj, Mario, Gonidakis, Fragiskos, Tziouvas, Konstantinos, Papezova, Hana, Yilmaz, Zeynep, Wagner, Gudrun, Cohen-Woods, Sarah, Herms, Stefan, Julià, Antonio, Rabionet, Raquel, Dick, Danielle M, Ripatti, Samuli, Andreassen, Ole A, Espeseth, Thomas, Lundervold, Astri J, Steen, Vidar M, Pinto, Dalila, Scherer, Stephen W, Aschauer, Harald, Schosser, Alexandra, Alfredsson, Lars, Padyukov, Leonid, Halmi, Katherine A, Mitchell, James, Strober, Michael, Bergen, Andrew W, Kaye, Walter, Szatkiewicz, Jin Peng, Cormand, Bru, Ramos-Quiroga, Josep Antoni, Sánchez-Mora, Cristina, Ribasés, Marta, Casas, Miguel, Hervas, Amaia, Arranz, Maria Jesús, Haavik, Jan, Zayats, Tetyana, Johansson, Stefan, Williams, Nigel, Dempfle, Astrid, Rothenberger, Aribert, Kuntsi, Jonna, Oades, Robert D, Banaschewski, Tobias, Franke, Barbara, Buitelaar, Jan K, Arias Vasquez, Alejandro, Doyle, Alysa E, Reif, Andreas, Lesch, Klaus-Peter, Freitag, Christine, Rivero, Olga, Palmason, Haukur, Romanos, Marcel, Langley, Kate, Rietschel, Marcella, Witt, Stephanie H, Dalsgaard, Soeren, Børglum, Anders D, Waldman, Irwin, Wilmot, Beth, Molly, Nikolas, Bau, Claiton HD, Crosbie, Jennifer, Schachar, Russell, Loo, Sandra K, McGough, James J, Grevet, Eugenio H, Medland, Sarah E, Robinson, Elise, Weiss, Lauren A, Bacchelli, Elena, Bailey, Anthony, Bal, Vanessa, Battaglia, Agatino, Betancur, Catalina, Bolton, Patrick, Cantor, Rita, Celestino-Soper, Patrícia, Dawson, Geraldine, De Rubeis, Silvia, Duque, Frederico, Green, Andrew, Klauck, Sabine M, Leboyer, Marion, Levitt, Pat, Maestrini, Elena, Mane, Shrikant, De-Luca, Daniel Moreno, Parr, Jeremy, Regan, Regina, Reichenberg, Abraham, Sandin, Sven, Vorstman, Jacob, Wassink, Thomas, Wijsman, Ellen, Cook, Edwin, Santangelo, Susan, Delorme, Richard, Rogé, Bernadette, Magalhaes, Tiago, Arking, Dan, Schulze, Thomas G, Thompson, Robert C, Strohmaier, Jana, Matthews, Keith, Melle, Ingrid, Morris, Derek, Blackwood, Douglas, McIntosh, Andrew, Bergen, Sarah E, Schalling, Martin, Jamain, Stéphane, Maaser, Anna, Fischer, Sascha B, Reinbold, Céline S, Fullerton, Janice M, Guzman-Parra, José, Mayoral, Fermin, Schofield, Peter R, Cichon, Sven, Mühleisen, Thomas W, Degenhardt, Franziska, Schumacher, Johannes, Bauer, Michael, Mitchell, Philip B, Gershon, Elliot S, Rice, John, Potash, James B, Zandi, Peter P, Craddock, Nick, Ferrier, I Nicol, Alda, Martin, Rouleau, Guy A, Turecki, Gustavo, Ophoff, Roel, Pato, Carlos, Anjorin, Adebayo, Stahl, Eli, Leber, Markus, Czerski, Piotr M, Cruceanu, Cristiana, Jones, Ian R, Posthuma, Danielle, Andlauer, Till FM, Forstner, Andreas J, Streit, Fabian, Baune, Bernhard T, Air, Tracy, Sinnamon, Grant, Wray, Naomi R, MacIntyre, Donald J, Porteous, David, Homuth, Georg, Rivera, Margarita, Grove, Jakob, Middeldorp, Christel M, Hickie, Ian, Pergadia, Michele, Mehta, Divya, Smit, Johannes H, Jansen, Rick, De Geus, Eco, Dunn, Erin, Li, Qingqin S, Nauck, Matthias, Schoevers, Robert A, Beekman, Aartjan Tf, Knowles, James A, Viktorin, Alexander, Arnold, Paul, Barr, Cathy L, Bedoya-Berrio, Gabriel, Bienvenu, O Joseph, Brentani, Helena, Burton, Christie, Camarena, Beatriz, Cappi, Carolina, Cath, Danielle, Cavallini, Maria, Cusi, Daniele, Darrow, Sabrina, Denys, Damiaan, Derks, Eske M, Dietrich, Andrea, Fernandez, Thomas, Figee, Martijn, Freimer, Nelson, Gerber, Gloria, Grados, Marco, Greenberg, Erica, Hanna, Gregory L, Hartmann, Andreas, Hirschtritt, Matthew E, Hoekstra, Pieter J, Huang, Alden, Huyser, Chaim, Illmann, Cornelia, Jenike, Michael, Kuperman, Samuel, Leventhal, Bennett, Lochner, Christine, Lyon, Gholson J, Macciardi, Fabio, Madruga-Garrido, Marcos, Malaty, Irene A, Maras, Athanasios, McGrath, Lauren, Miguel, Eurípedes C, Mir, Pablo, Nestadt, Gerald, Nicolini, Humberto, Okun, Michael S, Pakstis, Andrew, Paschou, Peristera, Piacentini, John, Pittenger, Christopher, Plessen, Kerstin, Ramensky, Vasily, Ramos, Eliana M, Reus, Victor, Richter, Margaret A, Riddle, Mark A, Robertson, Mary M, Roessner, Veit, Rosário, Maria, Samuels, Jack F, Sandor, Paul, Stein, Dan J, Tsetsos, Fotis, Van Nieuwerburgh, Filip, Weatherall, Sarah, Wendland, Jens R, Wolanczyk, Tomasz, Worbe, Yulia, Zai, Gwyneth, Goes, Fernando S, McLaughlin, Nicole, Nestadt, Paul S, Grabe, Hans-Jorgen, Depienne, Christel, Konkashbaev, Anuar, Lanzagorta, Nuria, Valencia-Duarte, Ana, Bramon, Elvira, Buccola, Nancy, Cahn, Wiepke, Cairns, Murray, Chong, Siow A, Cohen, David, Crespo-Facorro, Benedicto, Crowley, James, Davidson, Michael, DeLisi, Lynn, Dinan, Timothy, Donohoe, Gary, Drapeau, Elodie, Duan, Jubao, Haan, Lieuwe, Hougaard, David, Karachanak-Yankova, Sena, Khrunin, Andrey, Klovins, Janis, Kučinskas, Vaidutis, Lee Chee Keong, Jimmy, Limborska, Svetlana, Loughland, Carmel, Lönnqvist, Jouko, Maher, Brion, Mattheisen, Manuel, McDonald, Colm, Murphy, Kieran C, Nenadic, Igor, Van Os, Jim, Pantelis, Christos, Pato, Michele, Petryshen, Tracey, Quested, Digby, Roussos, Panos, Sanders, Alan R, Schall, Ulrich, Schwab, Sibylle G, Sim, Kang, So, Hon-Cheong, Stögmann, Elisabeth, Subramaniam, Mythily, Toncheva, Draga, Waddington, John, Walters, James, Weiser, Mark, Cheng, Wei, Cloninger, Robert, Curtis, David, Gejman, Pablo V, Henskens, Frans, Mattingsdal, Morten, Oh, Sang-Yun, Scott, Rodney, Webb, Bradley, Breen, Gerome, Churchhouse, Claire, Bulik, Cynthia M, Daly, Mark, Dichgans, Martin, Faraone, Stephen V, Guerreiro, Rita, Holmans, Peter, Kendler, Kenneth S, Koeleman, Bobby, Mathews, Carol A, Price, Alkes, Scharf, Jeremiah, Sklar, Pamela, Williams, Julie, Wood, Nicholas W, Cotsapas, Chris, Palotie, Aarno, Smoller, Jordan W, Sullivan, Patrick, Rosand, Jonathan, Corvin, Aiden, Neale, Benjamin M, Schott, Jonathan M, Anney, Richard, Elia, Josephine, Grigoroiu-Serbanescu, Maria, Edenberg, Howard J, Murray, Robin, Massachusetts General Hospital [Boston], Broad Institute of MIT and Harvard (BROAD INSTITUTE), Harvard Medical School [Boston] (HMS)-Massachusetts Institute of Technology (MIT)-Massachusetts General Hospital [Boston], UK Dementia Research Institute (UK DRI), University College of London [London] (UCL), School of Psychology [Cardiff University], Cardiff University, Institute for Stroke and Dementia Research (ISD), Klinikum der Universität [München]-Ludwig Maximilian University [Munich] (LMU), New Jersey Institute of Technology [Newark] (NJIT), Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 (RID-AGE), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), RIKEN Center for Integrative Medical Sciences [Yokohama] (RIKEN IMS), RIKEN - Institute of Physical and Chemical Research [Japon] (RIKEN), Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC), Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Laboratoire de Biotechnologie et Microbiologie Appliquée (LBMA), Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de neurologie [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU), Institut de Biologie François JACOB (JACOB), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Gériatrie générale et aigüe [Paris], AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Columbia University [New York], Dpt of Neuroscience [New York], Icahn School of Medicine at Mount Sinai [New York] (MSSM), University of Pittsburgh (PITT), Pennsylvania Commonwealth System of Higher Education (PCSHE), University of Washington [Seattle], Tanz Center Research in Neurodegenerative Diseases [Toronto], University of Toronto, Children’s Hospital of Philadelphia (CHOP ), University of Kentucky (UK), School of medicine, Duke University [Durham], College of medicine, Brigham Young University (BYU), Oregon Health and Science University [Portland] (OHSU), Cleveland Clinic, Department of Neurology, Emory University [Atlanta, GA], Medical School, University of Michigan [Ann Arbor], University of Michigan System-University of Michigan System, Health sciences center, The University of New Mexico [Albuquerque], Institute for Memory Impairments and Neurological Disorders [Irvine], University of California [Irvine] (UC Irvine), University of California (UC)-University of California (UC), Indiana University - Purdue University Indianapolis (IUPUI), Indiana University System, Keck School of Medicine [Los Angeles], University of Southern California (USC), University of South Florida [Tampa] (USF), University of Utah School of Medicine [Salt Lake City], Boston University School of Medicine (BUSM), Boston University [Boston] (BU), Perelman School of Medicine, University of Pennsylvania, Dublin City University [Dublin] (DCU), Functional Genomics Center Zurich, Universität Zürich [Zürich] = University of Zurich (UZH)- Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Cambridge Institute for Medical Research (CIMR), University of Cambridge [UK] (CAM), Aristotle University of Thessaloniki, Maurice Wohl Clinical Neuroscience Institut, King‘s College London, Dementia Research Centre [London] (DRC), Groupe de recherche clinique Alzheimer Precision Medicine (GRC 21 - APM), Sorbonne Université (SU), MRC Centre for Neuropsychiatric Genetics and Genomics, Medical Research Council-Cardiff University, MRC Prion Unit [London], Queen's University [Belfast] (QUB), School of Life Sciences, University of Nottingham, UK (UON), Rheinische Friedrich-Wilhelms-Universität Bonn, Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), QIMR Berghofer Medical Research Institute, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), School of Medicine [Dublin], Trinity College Dublin, Department of Medicine, University of Texas Health Science Center, The University of Texas Health Science Center at Houston (UTHealth), School of Public Health [Boston], Erasmus University Medical Center [Rotterdam] (Erasmus MC), Columbia University Medical Center (CUMC), David Geffen School of Medicine [Los Angeles], University of California [Los Angeles] (UCLA), Saarland University [Saarbrücken], Universität Leipzig, School of Medicine [Los Angeles], Johannes Kepler Universität Linz - Johannes Kepler University Linz [Autriche] (JKU), Department of Neurology [Boston], Harvard Medical School [Boston] (HMS)-Massachusetts General Hospital [Boston], School of Medecine, Washington University in Saint Louis (WUSTL), Oslo University Hospital [Oslo], Institute for Molecular Medicine Finland [Helsinki] (FIMM), Helsinki Institute of Life Science (HiLIFE), Helsingin yliopisto = Helsingfors universitet = University of Helsinki-Helsingin yliopisto = Helsingfors universitet = University of Helsinki, 23andMe Inc., Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Department of Biological Psychology [Amsterdam], Vrije Universiteit Amsterdam [Amsterdam] (VU), Leiden University Medical Center (LUMC), Universiteit Leiden, University-Hospital Munich-Großhadern [München], Karolinska Institutet [Stockholm], Universität Ulm - Ulm University [Ulm, Allemagne], Faculty of Medicine and Life Sciences [Tampere], University of Tampere [Finland], Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Brigham & Women’s Hospital [Boston] (BWH), Harvard Medical School [Boston] (HMS), Landspitali National University Hospital of Iceland, VU University Medical Center [Amsterdam], Boston VA Research Institute (BVARI), Department of Physiology, Anatomy and Genetics [Oxford], University of Oxford, Max Planck Institute of Psychiatry, Max-Planck-Gesellschaft, Christian-Albrechts-Universität zu Kiel (CAU), Institute of Clinical Molecular Biology, Kiel University, National Institute for Health and Welfare [Helsinki], Harvard T.H. Chan School of Public Health, Universitat Autònoma de Barcelona (UAB), Vall d'Hebron University Hospital [Barcelona], University of Tartu, Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg] (UKE), Center for Human and Clinical Genetics, Universiteit Leiden-Universiteit Leiden, University of Copenhagen = Københavns Universitet (UCPH), Institute of Health and Biomedical Innovation (IHBI), Queensland University of Technology [Brisbane] (QUT), Discipline of Psychiatry [Dublin], Trinity College Dublin-Trinity College Dublin, Institute of Neurology [London], The University of Hong Kong (HKU), University of Melbourne, Cooper Medical School of Rowan University [Camden] (CMSRU), Centre Hospitalier de l'Université de Montréal (CHUM), Université de Montréal (UdeM), University of Antwerp (UA), Hôpital Erasme [Bruxelles] (ULB), Faculté de Médecine [Bruxelles] (ULB), Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB), New York University School of Medicine (NYU), New York University School of Medicine, NYU System (NYU)-NYU System (NYU), University of Eastern Finland, Universitätsklinikum Bonn (UKB), Hertie Institute for Clinical Brain Research [Tubingen], University of Tübingen, NIHR Biomedical Research Centre [London], Guy's and St Thomas' NHS Foundation Trust-King‘s College London, University Medical Center [Utrecht], Ohio State University [Columbus] (OSU), University of California [San Francisco] (UC San Francisco), University of California (UC), Royal College of Surgeons in Ireland (RCSI), University of Southern Denmark (SDU), United Christian Hospital [Hong Kong] (UCH), University of Cincinnati (UC), University of Cologne, Inselspital Bern, University of Wales, Jefferson University Hospitals, University of Liverpool, Medizinische Universität Wien = Medical University of Vienna, National Institutes of Health [Bethesda] (NIH), German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Institut de Recherche en Santé Digestive (IRSD ), Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Lincoln, University of Newcastle [Callaghan, Australia] (UoN), Fondazione IRCCS Istituto Neurologico 'Carlo Besta', University of Virginia, University of Maryland [Baltimore County] (UMBC), University of Maryland System, Royal Holloway [University of London] (RHUL), University of Edinburgh, Universidade de Lisboa = University of Lisbon (ULISBOA), Uniwersytet Jagielloński w Krakowie = Jagiellonian University (UJ), University of Split, University of North Carolina [Chapel Hill] (UNC), University of North Carolina System (UNC), Center for Genomic Regulation (CRG-UPF), CIBER de Epidemiología y Salud Pública (CIBERESP), McLean Hospital [Belmont, Ma.], Norwegian Institute of Public Health [Oslo] (NIPH), Università degli Studi di Salerno = University of Salerno (UNISA), University of Bristol [Bristol], Technische Universität Dresden = Dresden University of Technology (TU Dresden), Rheinisch-Westfälische Technische Hochschule Aachen University (RWTH), Utrecht University [Utrecht], Azienda Ospedaliera di Padova, Université de Liège, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology (MCMCC), Università degli Studi di Perugia = University of Perugia (UNIPG), Università degli studi della Campania 'Luigi Vanvitelli' = University of the Study of Campania Luigi Vanvitelli, National and Kapodistrian University of Athens (NKUA), Charles University [Prague] (CU), SURFACES, Institut de recherches sur la catalyse et l'environnement de Lyon (IRCELYON), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Flinders University [Adelaide, Australia], Virginia Commonwealth University (VCU), University of Oslo (UiO), University of Bergen (UiB), Weill Medical College of Cornell University [New York], University of North Dakota [Grand Forks] (UND), Oregon Research Institute (ORI), University of California [San Diego] (UC San Diego), Universitat de Barcelona (UB), Centro de Investigación Biomédica en Red Salud Mental [Madrid] (CIBER-SAM), Hospital Universitario Mutua de Terrassa, School of Computer Science and Communication [Stockholm], Royal Institute of Technology [Stockholm] (KTH ), Jefferson (Philadelphia University + Thomas Jefferson University), University Medical Center Göttingen (UMG), Universität Heidelberg [Heidelberg] = Heidelberg University, Radboud University Medical Center [Nijmegen], Universitätsklinikum Frankfurt, Maastricht University [Maastricht], Institute of Psychological Medicine and Clinical Neurosciences, Aarhus University [Aarhus], University of Iowa [Iowa City], Universidade Federal do Rio Grande do Sul [Porto Alegre] (UFRGS), The Hospital for sick children [Toronto] (SickKids), Hospital de Clínicas de Porto Alegre (HCPA), Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), University of British Columbia (UBC), IRCCS Fondazione Stella Maris [Pisa], Institut de Biologie Paris Seine (IBPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Neuroscience Paris Seine (NPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie Paris Seine (IBPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Universidade de Coimbra [Coimbra], Academic Centre on Rare Diseases (ACoRD), University College Dublin [Dublin] (UCD), Our Lady's Children's Hospital Crumlin (OLCHC), German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Children’s Hospital Los Angeles [Los Angeles], Yale University [New Haven], Brown University, Institute of Neuroscience [Newcastle] (ION), Newcastle University [Newcastle], Department of Medical Epidemiology and Biostatistics (MEB), Division of Medical Genetics [Seattle], University of Illinois [Chicago] (UIC), University of Illinois System, Maine Medical Center Research Institute (MMCRI), Génétique humaine et fonctions cognitives - Human Genetics and Cognitive Functions (GHFC (UMR_3571 / U-Pasteur_1)), Institut Pasteur [Paris] (IP)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Centre d’Etudes et de Recherches en Psychopathologie et Psychologie de la Santé (CERPPS), Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-Toulouse Mind & Brain Institut (TMBI), Université de Toulouse (UT)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT), Johns Hopkins University School of Medicine [Baltimore], Ludwig Maximilian University [Munich] (LMU), University of Michigan System, Department of Genetic Epidemiology in Psychiatry [Mannhein], Universität Heidelberg [Heidelberg] = Heidelberg University-Central Institute of Mental Health Mannheim, University of Dundee, National University of Ireland [Galway] (NUI Galway), University Hospital Basel [Basel], Neuroscience Research Australia (NeuRA), Forschungszentrum Jülich GmbH | Centre de recherche de Juliers, Helmholtz-Gemeinschaft = Helmholtz Association, UNSW Faculty of Medicine [Sydney], University of New South Wales [Sydney] (UNSW), University of Chicago, Johns Hopkins University (JHU), Johns Hopkins Bloomberg School of Public Health [Baltimore], Dalhousie University [Halifax], Montreal Neurological Institute and Hospital, McGill University = Université McGill [Montréal, Canada], State University of New York (SUNY), University Hospital of Cologne [Cologne], University of Adelaide, James Cook University (JCU), Institute for Molecular Bioscience, University of Queensland [Brisbane], Greifswald University Hospital, The University of Sydney, University Medical Center Groningen [Groningen] (UMCG), University of Calgary, University Health Network, Universidad de Antioquia = University of Antioquia [Medellín, Colombia], Universidade de São Paulo = University of São Paulo (USP), Ospedale San Raffaele, University of Amsterdam [Amsterdam] (UvA), University of Groningen [Groningen], Yale School of Medicine [New Haven, Connecticut] (YSM), Academic Medical Center - Academisch Medisch Centrum [Amsterdam] (AMC), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), University of Cape Town, Cold Spring Harbor Laboratory (CSHL), Universidad de Sevilla / University of Sevilla, University of Florida [Gainesville] (UF), University of Denver, Purdue University [West Lafayette], Centre Hospitalier Universitaire Vaudois [Lausanne] (CHUV), Moscow Institute of Physics and Technology [Moscow] (MIPT), Sunnybrook Health Sciences Centre, Federal Institute of São Paulo (IFSP), Democritus University of Thrace (DUTH), Universiteit Gent = Ghent University (UGENT), Medical University of Warsaw - Poland, Sorbonne Université - Faculté de Médecine - Département d'Enseignement et de Recherche en Médecine Générale, Universitätsklinikum Essen [Universität Duisburg-Essen] (Uniklinik Essen), Vanderbilt University Medical Center [Nashville], Vanderbilt University [Nashville], Institute of Mental Health [Singapore], Universidad de Cantabria [Santander], Tel Aviv University (TAU), University College Cork (UCC), University of Rochester [USA], Statens Serum Institut [Copenhagen], Софийски университет = Sofia University, Russian Academy of Sciences [Moscow] (RAS), Latvian Biomedical Research and Study Centre [Rīga], Vilnius University [Vilnius], Nanyang Technological University [Singapour], Department of Life Sciences, Imperial College London, Jena University Hospital [Jena], Oxford University Hospitals NHS Trust, Schizophrenia Research Institute [Sydney], Faculty of Science, Medicine and Health [Wollongong], University of Wollongong [Australia], City University of Hong Kong [Hong Kong] (CUHK), Lawrence Berkeley National Laboratory [Berkeley] (LBNL), This work was supported by grants 1R01MH10764901 and 5U01MH09443203 from the National Institute of Mental Health, as well as the Orion Farmos Research Foundation (V.A.) and the Fannie and John Hertz Foundation (H.K.F.). Consortium specific funding is detailed in the supplementary materials ('Study-specific acknowledgments')., Brainstorm Consortium, University of Kentucky, University of California [Irvine] (UCI), University of California-University of California, University of Pennsylvania [Philadelphia], Alzheimer Precision Medicine [CHU Pitié-Salpétriêre] (GRC 21 AMP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Universität Leipzig [Leipzig], Johannes Kepler University Linz [Linz] (JKU), University of Helsinki-University of Helsinki, University of Helsinki, University of Oxford [Oxford], University of Copenhagen = Københavns Universitet (KU), University of California [San Francisco] (UCSF), University of California, Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Newcastle [Australia] (UoN), University of Virginia [Charlottesville], Universidade de Lisboa (ULISBOA), Università degli Studi di Salerno (UNISA), Rheinisch-Westfälische Technische Hochschule Aachen (RWTH), Università degli Studi di Perugia (UNIPG), Università degli studi della Campania 'Luigi Vanvitelli', Universität Heidelberg [Heidelberg], Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris]-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Universität Heidelberg [Heidelberg]-Central Institute of Mental Health Mannheim, VU University Amsterdam, Universidade de São Paulo (USP), Yale University School of Medicine, Universidad de Sevilla, Universiteit Gent = Ghent University [Belgium] (UGENT), Service de Psychiatrie de l'Enfant et de l'Adolescent [CHU Pitié-Salpêtrière] (SPEA), Tel Aviv University [Tel Aviv], University of Sofia, Anttila, Verneri, Bulik-Sullivan, Brendan, Finucane, Hilary K., Walters, Raymond K., Bras, Jose, Duncan, Laramie, Escott-Price, Valentina, Falcone, Guido J., Gormley, Padhraig, Malik, Rainer, Patsopoulos, Nikolaos A., Ripke, Stephan, Wei, Zhi, Yu, Dongmei, Lee, Phil H., Turley, Patrick, Grenier-Boley, Benjamin, Chouraki, Vincent, Kamatani, Yoichiro, Berr, Claudine, Letenneur, Luc, Hannequin, Didier, Amouyel, Philippe, Boland, Anne, Deleuze, Jean-Françoi, Duron, Emmanuelle, Vardarajan, Badri N., Reitz, Christiane, Goate, Alison M., Huentelman, Matthew J., Ilyas Kamboh, M., Larson, Eric B., Rogaeva, Ekaterina, George-Hyslop, Peter St, Hakonarson, Hakon, Kukull, Walter A., Farrer, Lindsay A., Barnes, Lisa L., Beach, Thomas G., Yesim Demirci, F., Head, Elizabeth, Hulette, Christine M., Jicha, Gregory A., Kauwe, John S.K., Kaye, Jeffrey A., Leverenz, James B., Levey, Allan I., Lieberman, Andrew P., Pankratz, Vernon S., Poon, Wayne W., Quinn, Joseph F., Saykin, Andrew J., Schneider, Lon S., Smith, Amanda G., Sonnen, Joshua A., Stern, Robert A., Van Deerlin, Vivianna M., Van Eldik, Linda J., Harold, Denise, Russo, Giancarlo, Rubinsztein, David C., Bayer, Anthony, Tsolaki, Magda, Proitsi, Petra, Fox, Nick C., Hampel, Harald, Owen, Michael J., Mead, Simon, Passmore, Peter, Morgan, Kevin, Nöthen, Markus M., Rossor, Martin, Lupton, Michelle K., Hoffmann, Per, Kornhuber, Johanne, Lawlor, Brian, McQuillin, Andrew, Al-Chalabi, Ammar, Bis, Joshua C., Ruiz, Agustin, Boada, Mercè, Seshadri, Sudha, Beiser, Alexa, Rice, Kenneth, Van Der Lee, Sven J., De Jager, Philip L., Geschwind, Daniel H., Riemenschneider, Matthia, Riedel-Heller, Steffi, Rotter, Jerome I., Ransmayr, Gerhard, Hyman, Bradley T., Cruchaga, Carlo, Alegret, Montserrat, Winsvold, Bendik, Palta, Priit, Farh, Kai-How, Cuenca-Leon, Ester, Furlotte, Nichola, Kurth, Tobia, Ligthart, Lannie, Terwindt, Gisela M., Freilinger, Tobia, Ran, Caroline, Gordon, Scott D., Borck, Guntram, Adams, Hieab H.H., Lehtimäki, Terho, Wedenoja, Juho, Buring, Julie E., Schürks, Marku, Hrafnsdottir, Maria, Hottenga, Jouke-Jan, Penninx, Brenda, Artto, Ville, Kaunisto, Mari, Vepsäläinen, Salli, Martin, Nicholas G., Montgomery, Grant W., Kurki, Mitja I., Hämäläinen, Eija, Huang, Hailiang, Huang, Jie, Sandor, Cynthia, Webber, Caleb, Muller-Myhsok, Bertram, Schreiber, Stefan, Salomaa, Veikko, Loehrer, Elizabeth, Göbel, Hartmut, Macaya, Alfon, Pozo-Rosich, Patricia, Hansen, Thoma, Werge, Thoma, Kaprio, Jaakko, Metspalu, Andre, Kubisch, Christian, Ferrari, Michel D., Belin, Andrea C., Van Den Maagdenberg, Arn M. J. M., Zwart, John-Anker, Boomsma, Dorret, Eriksson, Nichola, Olesen, Je, Chasman, Daniel I., Nyholt, Dale R., Avbersek, Andreja, Baum, Larry, Berkovic, Samuel, Bradfield, Jonathan, Buono, Russell, Catarino, Claudia B., Cossette, Patrick, De Jonghe, Peter, Depondt, Chantal, Dlugos, Denni, Ferraro, Thomas N., French, Jacqueline, Hjalgrim, Helle, Jamnadas-Khoda, Jennifer, Kälviäinen, Reetta, Kunz, Wolfram S., Lerche, Holger, Leu, Costin, Lindhout, Dick, Lo, Warren, Lowenstein, Daniel, McCormack, Mark, Møller, Rikke S., Molloy, Anne, Ng, Ping-Wing, Oliver, Karen, Privitera, Michael, Radtke, Rodney, Ruppert, Ann-Kathrin, Sander, Thoma, Schachter, Steven, Schankin, Christoph, Scheffer, Ingrid, Schoch, Susanne, Sisodiya, Sanjay M., Smith, Philip, Sperling, Michael, Striano, Pasquale, Surges, Rainer, Neil Thomas, G., Visscher, Frank, Whelan, Christopher D., Zara, Federico, Heinzen, Erin L., Marson, Anthony, Becker, Felicita, Stroink, Han, Zimprich, Fritz, Gasser, Thoma, Gibbs, Raphael, Heutink, Peter, Martinez, Maria, Morris, Huw R., Sharma, Manu, Ryten, Mina, Mok, Kin Y., Pulit, Sara, Bevan, Steve, Holliday, Elizabeth, Attia, John, Battey, Thoma, Boncoraglio, Giorgio, Thijs, Vincent, Chen, Wei-Min, Mitchell, Braxton, Rothwell, Peter, Sharma, Pankaj, Sudlow, Cathie, Vicente, Astrid, Markus, Hugh, Kourkoulis, Christina, Pera, Joana, Raffeld, Miriam, Silliman, Scott, Perica, Vesna Boraska, Thornton, Laura M., Huckins, Laura M., William Rayner, N., Lewis, Cathryn M., Gratacos, Monica, Rybakowski, Filip, Keski-Rahkonen, Anna, Raevuori, Anu, Hudson, James I., Reichborn-Kjennerud, Ted, Monteleone, Palmiero, Karwautz, Andrea, Mannik, Katrin, Baker, Jessica H., O'Toole, Julie K., Trace, Sara E., Davis, Oliver S. P., Helder, Sietske G., Ehrlich, Stefan, Herpertz-Dahlmann, Beate, Danner, Unna N., Van Elburg, Annemarie A., Clementi, Maurizio, Forzan, Monica, Docampo, Elisa, Lissowska, Jolanta, Hauser, Joanna, Tortorella, Alfonso, Maj, Mario, Gonidakis, Fragisko, Tziouvas, Konstantino, Papezova, Hana, Yilmaz, Zeynep, Wagner, Gudrun, Cohen-Woods, Sarah, Herms, Stefan, Julia, Antonio, Rabionet, Raquel, Dick, Danielle M., Ripatti, Samuli, Andreassen, Ole A., Espeseth, Thoma, Lundervold, Astri J., Steen, Vidar M., Pinto, Dalila, Scherer, Stephen W., Aschauer, Harald, Schosser, Alexandra, Alfredsson, Lar, Padyukov, Leonid, Halmi, Katherine A., Mitchell, Jame, Strober, Michael, Bergen, Andrew W., Kaye, Walter, Szatkiewicz, Jin Peng, Cormand, Bru, Ramos-Quiroga, Josep Antoni, Sánchez-Mora, Cristina, Ribasés, Marta, Casas, Miguel, Hervas, Amaia, Arranz, Maria Jesú, Haavik, Jan, Zayats, Tetyana, Johansson, Stefan, Williams, Nigel, Dempfle, Astrid, Rothenberger, Aribert, Kuntsi, Jonna, Oades, Robert D., Banaschewski, Tobia, Franke, Barbara, Buitelaar, Jan K., Vasquez, Alejandro Aria, Doyle, Alysa E., Reif, Andrea, Lesch, Klaus-Peter, Freitag, Christine, Rivero, Olga, Palmason, Haukur, Romanos, Marcel, Langley, Kate, Rietschel, Marcella, Witt, Stephanie H., Dalsgaard, Soeren, Børglum, Anders D., Waldman, Irwin, Wilmot, Beth, Molly, Nikola, Bau, Claiton H.D., Crosbie, Jennifer, Schachar, Russell, Loo, Sandra K., McGough, James J., Grevet, Eugenio H., Medland, Sarah E., Robinson, Elise, Weiss, Lauren A., Bacchelli, Elena, Bailey, Anthony, Bal, Vanessa, Battaglia, Agatino, Betancur, Catalina, Bolton, Patrick, Cantor, Rita, Celestino-Soper, Patrícia, Dawson, Geraldine, De Rubeis, Silvia, Duque, Frederico, Green, Andrew, Klauck, Sabine M., Leboyer, Marion, Levitt, Pat, Maestrini, Elena, Mane, Shrikant, Moreno-De-Luca, Daniel, Parr, Jeremy, Regan, Regina, Reichenberg, Abraham, Sandin, Sven, Vorstman, Jacob, Wassink, Thoma, Wijsman, Ellen, Cook, Edwin, Santangelo, Susan, Delorme, Richard, Roge, Bernadette, Magalhaes, Tiago, Arking, Dan, Schulze, Thomas G., Thompson, Robert C., Strohmaier, Jana, Matthews, Keith, Melle, Ingrid, Morris, Derek, Blackwood, Dougla, McIntosh, Andrew, Bergen, Sarah E., Schalling, Martin, Jamain, Stéphane, Maaser, Anna, Fischer, Sascha B., Reinbold, Céline S., Fullerton, Janice M., Guzman-Parra, José, Mayoral, Fermin, Schofield, Peter R., Cichon, Sven, Mühleisen, Thomas W., Degenhardt, Franziska, Schumacher, Johanne, Bauer, Michael, Mitchell, Philip B., Gershon, Elliot S., Rice, John, Potash, James B., Zandi, Peter P., Craddock, Nick, Nicol Ferrier, I., Alda, Martin, Rouleau, Guy A., Turecki, Gustavo, Ophoff, Roel, Pato, Carlo, Anjorin, Adebayo, Stahl, Eli, Leber, Marku, Czerski, Piotr M., Cruceanu, Cristiana, Jones, Ian R., Posthuma, Danielle, Andlauer, Till F.M., Forstner, Andreas J., Streit, Fabian, Baune, Bernhard T., Air, Tracy, Sinnamon, Grant, Wray, Naomi R., MacIntyre, Donald J., Porteous, David, Homuth, Georg, Rivera, Margarita, Grove, Jakob, Middeldorp, Christel M., Hickie, Ian, Pergadia, Michele, Mehta, Divya, Smit, Johannes H., Jansen, Rick, De Geus, Eco, Dunn, Erin, Li, Qingqin S., Nauck, Matthia, Schoevers, Robert A., Beekman, Aartjan TF, Knowles, James A., Viktorin, Alexander, Arnold, Paul, Barr, Cathy L., Bedoya-Berrio, Gabriel, Joseph Bienvenu, O., Brentani, Helena, Burton, Christie, Camarena, Beatriz, Cappi, Carolina, Cath, Danielle, Cavallini, Maria, Cusi, Daniele, Darrow, Sabrina, Denys, Damiaan, Derks, Eske M., Dietrich, Andrea, Fernandez, Thoma, Figee, Martijn, Freimer, Nelson, Gerber, Gloria, Grados, Marco, Greenberg, Erica, Hanna, Gregory L., Hartmann, Andrea, Hirschtritt, Matthew E., Hoekstra, Pieter J., Huang, Alden, Huyser, Chaim, Illmann, Cornelia, Jenike, Michael, Kuperman, Samuel, Leventhal, Bennett, Lochner, Christine, Lyon, Gholson J., Macciardi, Fabio, Madruga-Garrido, Marco, Malaty, Irene A., Maras, Athanasio, McGrath, Lauren, Miguel, Eurípedes C., Mir, Pablo, Nestadt, Gerald, Nicolini, Humberto, Okun, Michael S., Pakstis, Andrew, Paschou, Peristera, Piacentini, John, Pittenger, Christopher, Plessen, Kerstin, Ramensky, Vasily, Ramos, Eliana M., Reus, Victor, Richter, Margaret A., Riddle, Mark A., Robertson, Mary M., Roessner, Veit, Rosário, Maria, Samuels, Jack F., Sandor, Paul, Stein, Dan J., Tsetsos, Foti, Van Nieuwerburgh, Filip, Weatherall, Sarah, Wendland, Jens R., Wolanczyk, Tomasz, Worbe, Yulia, Zai, Gwyneth, Goes, Fernando S., McLaughlin, Nicole, Nestadt, Paul S., Grabe, Hans-Jorgen, Depienne, Christel, Konkashbaev, Anuar, Lanzagorta, Nuria, Valencia-Duarte, Ana, Bramon, Elvira, Buccola, Nancy, Cahn, Wiepke, Cairns, Murray, Chong, Siow A., Cohen, David, Crespo-Facorro, Benedicto, Crowley, Jame, Davidson, Michael, DeLisi, Lynn, Dinan, Timothy, Donohoe, Gary, Drapeau, Elodie, Duan, Jubao, Haan, Lieuwe, Hougaard, David, Karachanak-Yankova, Sena, Khrunin, Andrey, Klovins, Jani, Kučinskas, Vaiduti, Keong, Jimmy Lee Chee, Limborska, Svetlana, Loughland, Carmel, Lönnqvist, Jouko, Maher, Brion, Mattheisen, Manuel, McDonald, Colm, Murphy, Kieran C., Nenadic, Igor, Van Os, Jim, Pantelis, Christo, Pato, Michele, Petryshen, Tracey, Quested, Digby, Roussos, Pano, Sanders, Alan R., Schall, Ulrich, Schwab, Sibylle G., Sim, Kang, So, Hon-Cheong, Stögmann, Elisabeth, Subramaniam, Mythily, Toncheva, Draga, Waddington, John, Walters, Jame, Weiser, Mark, Cheng, Wei, Cloninger, Robert, Curtis, David, Gejman, Pablo V., Henskens, Fran, Mattingsdal, Morten, Oh, Sang-Yun, Scott, Rodney, Webb, Bradley, Breen, Gerome, Churchhouse, Claire, Bulik, Cynthia M., Daly, Mark, Dichgans, Martin, Faraone, Stephen V., Guerreiro, Rita, Holmans, Peter, Kendler, Kenneth S., Koeleman, Bobby, Mathews, Carol A., Price, Alke, Scharf, Jeremiah, Sklar, Pamela, Williams, Julie, Wood, Nicholas W., Cotsapas, Chri, Palotie, Aarno, Smoller, Jordan W., Sullivan, Patrick, Rosand, Jonathan, Corvin, Aiden, Neale, Benjamin M., Epidemiology, Radiology & Nuclear Medicine, Anttila, V, 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K., Mcquillin, Andrew, Adams, Hieab H. H., Mccormack, Mark, Bau, Claiton H. D., Mcgough, James J., Mcintosh, Andrew, Andlauer, Till F. M., Macintyre, Donald J., Mcgrath, Lauren, Mclaughlin, Nicole, Delisi, Lynn, Mcdonald, Colm, Université Montpellier 1 (UM1)-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Vrije universiteit = Free university of Amsterdam [Amsterdam] (VU), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement (Inserm U1167 - RID-AGE - Institut Pasteur), RIKEN Center for Integrative Medical Science, Neuropsychiatrie : recherche épidémiologique et clinique, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 1 (UM1)-Université de Montpellier (UM), University of South Florida (USF), University of Zürich [Zürich] (UZH)-Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology in Zürich [Zürich] (ETH Zürich), Alzheimer Precision Medicine GRC n°21 (APM), CHU Pitié-Salpêtrière [APHP], Cardiff University-Medical Research Council, Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Aix Marseille Université (AMU), Johannes Kepler University Linz [linz] (JKU), Washington University in St Louis, Charité - Universitätsmedizin Berlin / Charite - University Medicine Berlin, Universitat Autònoma de Barcelona [Barcelona] (UAB), Hôpital Erasme (Bruxelles), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Jagiellonian University [Krakow] (UJ), Technische Universität Dresden (TUD), National and Kapodistrian University of Athens = University of Athens (NKUA | UoA), Charles University [Prague], Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), University of Bergen (UIB), University Medicine Goettingen, Università di Bologna [Bologna] (UNIBO), Forschungszentrum Jülich GmbH, UNSW Medicine [Sydney], McGill University, Universidad de Antioquia, University of Florida [Gainesville], Universiteit Gent [Ghent], Service Psychiatrie de l'Enfant et de l'Adolescent [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Pitié-Salpêtrière [APHP], University of Wollongong, Alzheimer Precision Medicine [CHU Pitié-Salpétriêre] (GRC 21 APM), Anttila, Verneri [0000-0002-0073-4675], Finucane, Hilary K [0000-0003-3864-9828], Walters, Raymond K [0000-0001-8422-6530], Duncan, Laramie [0000-0003-1131-661X], Escott-Price, Valentina [0000-0003-1784-5483], Falcone, Guido J [0000-0002-6407-0302], Gormley, Padhraig [0000-0002-8908-6968], Malik, Rainer [0000-0001-9212-2520], Ripke, Stephan [0000-0003-3622-835X], Wei, Zhi [0000-0001-6059-4267], Yu, Dongmei [0000-0001-7901-4365], Lee, Phil H [0000-0003-1770-3100], Breen, Gerome [0000-0003-2053-1792], Bulik, Cynthia M [0000-0001-7772-3264], Daly, Mark [0000-0002-0949-8752], Dichgans, Martin [0000-0002-0654-387X], Faraone, Stephen V [0000-0002-9217-3982], Holmans, Peter [0000-0003-0870-9412], Koeleman, Bobby [0000-0001-7749-182X], Mathews, Carol A [0000-0003-2208-7058], Sklar, Pamela [0000-0001-9715-4943], Williams, Julie [0000-0002-4069-0259], Wood, Nicholas W [0000-0002-9500-3348], Cotsapas, Chris [0000-0002-7772-5910], Smoller, Jordan W [0000-0002-0381-6334], Sullivan, Patrick [0000-0002-6619-873X], Rosand, Jonathan [0000-0002-1014-9138], Corvin, Aiden [0000-0001-6717-4089], Neale, Benjamin M [0000-0003-1513-6077], and Apollo - University of Cambridge Repository
Subjects: Etiology, [SDV]Life Sciences [q-bio], MESH: Brain Diseases, body-mass index, genetics [Mental Disorders], Disorders of the Brain, Risks factors, classification [Mental Disorders], MESH: Quantitative Trait, Heritable, MESH: Risk Factors, Risk Factors, MESH: Genetic Variation, alzheimers-disease, 610 Medicine & health, bipolar disorder, Brain Diseases, deficit hyperactivity disorder, Multidisciplinary, Mental Disorders, genetics [Brain Diseases], Brain Disease, Brain, Genetic Variation, Genome-Wide Association Study, Humans, Phenotype, Quantitative Trait, Heritable, Psychiatric Disorders, anorexia-nervosa, Mental Disorder, Psychiatric Genomics, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], long-term survival, Engineering sciences. Technology, Human, General Science & Technology, population-based twin, diagnosis [Mental Disorders], MESH: Phenotype, Neurological Disorders, Quantitative Trait, MD Multidisciplinary, MESH: Mental Disorders, diagnosis [Brain Diseases], Heritable, genetic correlations, [SDV.GEN]Life Sciences [q-bio]/Genetics, MESH: Humans, major depressive disorder, Risk Factor, Brain Diseases/classification, Brain Diseases/diagnosis, Brain Diseases/genetics, Mental Disorders/classification, Mental Disorders/diagnosis, Mental Disorders/genetics, classification [Brain Diseases], Perturbações do Desenvolvimento Infantil e Saúde Mental, ddc:320, MESH: Genome-Wide Association Study, genome-wide association, Brainstorm Consortium, Genetic Factors, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: INTRODUCTION Brain disorders may exhibit shared symptoms and substantial epidemiological comorbidity, inciting debate about their etiologic overlap. However, detailed study of phenotypes with different ages of onset, severity, and presentation poses a considerable challenge. Recently developed heritability methods allow us to accurately measure correlation of genome-wide common variant risk between two phenotypes from pools of different individuals and assess how connected they, or at least their genetic risks, are on the genomic level. We used genome-wide association data for 265,218 patients and 784,643 control participants, as well as 17 phenotypes from a total of 1,191,588 individuals, to quantify the degree of overlap for genetic risk factors of 25 common brain disorders. RATIONALE Over the past century, the classification of brain disorders has evolved to reflect the medical and scientific communities’ assessments of the presumed root causes of clinical phenomena such as behavioral change, loss of motor function, or alterations of consciousness. Directly observable phenomena (such as the presence of emboli, protein tangles, or unusual electrical activity patterns) generally define and separate neurological disorders from psychiatric disorders. Understanding the genetic underpinnings and categorical distinctions for brain disorders and related phenotypes may inform the search for their biological mechanisms. RESULTS Common variant risk for psychiatric disorders was shown to correlate significantly, especially among attention deficit hyperactivity disorder (ADHD), bipolar disorder, major depressive disorder (MDD), and schizophrenia. By contrast, neurological disorders appear more distinct from one another and from the psychiatric disorders, except for migraine, which was significantly correlated to ADHD, MDD, and Tourette syndrome. We demonstrate that, in the general population, the personality trait neuroticism is significantly correlated with almost every psychiatric disorder and migraine. We also identify significant genetic sharing between disorders and early life cognitive measures (e.g., years of education and college attainment) in the general population, demonstrating positive correlation with several psychiatric disorders (e.g., anorexia nervosa and bipolar disorder) and negative correlation with several neurological phenotypes (e.g., Alzheimer’s disease and ischemic stroke), even though the latter are considered to result from specific processes that occur later in life. Extensive simulations were also performed to inform how statistical power, diagnostic misclassification, and phenotypic heterogeneity influence genetic correlations. CONCLUSION The high degree of genetic correlation among many of the psychiatric disorders adds further evidence that their current clinical boundaries do not reflect distinct underlying pathogenic processes, at least on the genetic level. This suggests a deeply interconnected nature for psychiatric disorders, in contrast to neurological disorders, and underscores the need to refine psychiatric diagnostics. Genetically informed analyses may provide important “scaffolding” to support such restructuring of psychiatric nosology, which likely requires incorporating many levels of information. By contrast, we find limited evidence for widespread common genetic risk sharing among neurological disorders or across neurological and psychiatric disorders. We show that both psychiatric and neurological disorders have robust correlations with cognitive and personality measures. Further study is needed to evaluate whether overlapping genetic contributions to psychiatric pathology may influence treatment choices. Ultimately, such developments may pave the way toward reduced heterogeneity and improved diagnosis and treatment of psychiatric disorders.
Published: 2018

47. Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: A pooled analysis of 1018 population-based measurement studies with 88.6 million participants

Author: Yiallouros, Panayiotis K., Escobedo-de la Peña, Jorge, Zhou, Bin, Bentham, James, Di Cesare, Mariachiara, Bixby, Honor, Danaei, Goodarz, Hajifathalian, Kaveh, Taddei, Cristina, Carrillo-Larco, Rodrigo M., Djalalinia, Shirin, Khatibzadeh, Shahab, Lugero, Charles, Peykari, Niloofar, Zhang, Wan Zhu, Bennett, James, Bilano, Ver, Stevens, Gretchen A., Cowan, Melanie J., Riley, Leanne M., Chen, Zhengming, Hambleton, Ian R., Jackson, Rod T., Kengne, Andre Pascal, Khang, Young-Ho, Laxmaiah, Avula, Liu, Jing, Malekzadeh, Reza, Neuhauser, Hannelore K., Sorić, Maroje, Starc, Gregor, Sundström, Johan, Woodward, Mark, Ezzati, Majid, Abarca-Gómez, Leandra, Abdeen, Ziad A., Abu-Rmeileh, Niveen M., Acosta-Cazares, Benjamin, Adams, Robert J., Aekplakorn, Wichai, Afsana, Kaosar, Aguilar-Salinas, Carlos A., Agyemang, Charles, Ahmad, Noor Ani, Ahmadvand, Alireza, Ahrens, Wolfgang, Ajlouni, Kamel, Akhtaeva, Nazgul, Al-Raddadi, Rajaa, Ali, Mohamed M., Ali, Osman, Alkerwi, Ala'a, Aly, Eman, Amarapurkar, Deepak N., Amouyel, Philippe, Amuzu, Antoinette, Andersen, Lars Bo, Anderssen, Sigmund A., Ängquist, Lars H., Anjana, Ranjit Mohan, Ansong, Daniel, Aounallah-Skhiri, Hajer, Araújo, Joana, Ariansen, Inger, Aris, Tahir, Arlappa, Nimmathota, Arveiler, Dominique, Aryal, Krishna K., Aspelund, Thor, Assah, Felix K., Assunção, Maria Cecília F., Avdicová, Mária, Azevedo, Ana, Azizi, Fereidoun, Babu, Bontha V., Bahijri, Suhad, Balakrishna, Nagalla, Bamoshmoosh, Mohamed, Banach, Maciej, Bandosz, Piotr, Banegas, José R., Barbagallo, Carlo M., Barceló, Alberto, Barkat, Amina, Barros, Aluisio J. D., Barros, Mauro V., Bata, Iqbal, Batieha, Anwar M., Batyrbek, Assembekov, Baur, Louise A., Beaglehole, Robert, Romdhane, Habiba Ben, Benet, Mikhail, Benson, Lowell S., Bernabe-Ortiz, Antonio, Bernotiene, Gailute, Bettiol, Heloisa, Bhagyalaxmi, Aroor, Bharadwaj, Sumit, Bhargava, Santosh K., Bi, Yufang, Bikbov, Mukharram, Bista, Bihungum, Bjerregaard, Peter, Bjertness, Espen, Bjertness, Marius B., Björkelund, Cecilia, Blokstra, Anneke, Bo, Simona, Bobak, Martin, Boeing, Heiner, Boggia, Jose G., Boissonnet, Carlos P., Bongard, Vanina, Borchini, Rossana, Bovet, Pascal, Braeckman, Lutgart, Brajkovich, Imperia, Branca, Francesco, Breckenkamp, Juergen, Brenner, Hermann, Brewster, Lizzy M., Bruno, Graziella, Bueno-de-Mesquita, H. B(as), Bugge, Anna, Burns, Con, Bursztyn, Michael, de León, Antonio Cabrera, Cacciottolo, Joseph, Cai, Hui, Cameron, Christine, Can, Günay, Cândido, Ana Paula C., Capuano, Vincenzo, Cardoso, Viviane C., Carlsson, Axel C., Carvalho, Maria J., Casanueva, Felipe F., Casas, Juan-Pablo, Caserta, Carmelo A., Chamukuttan, Snehalatha, Chan, Angelique W., Chan, Queenie, Chaturvedi, Himanshu K., Chaturvedi, Nishi, Chen, Chien-Jen, Chen, Fangfang, Chen, Huashuai, Chen, Shuohua, Cheng, Ching-Yu, Dekkaki, Imane Cherkaoui, Chetrit, Angela, Chiolero, Arnaud, Chiou, Shu-Ti, Chirita-Emandi, Adela, Chirlaque, María-Dolores, Cho, Belong, Cho, Yumi, Christofaro, Diego G., Chudek, Jerzy, Cifkova, Renata, Cinteza, Eliza, Claessens, Frank, Clays, Els, Concin, Hans, Cooper, Cyrus, Cooper, Rachel, Coppinger, Tara C., Costanzo, Simona, Cottel, Dominique, Cowell, Chris, Craig, Cora L., Crujeiras, Ana B., Cruz, Juan J., D'Arrigo, Graziella, d'Orsi, Eleonora, Dallongeville, Jean, Damasceno, Albertino, Dankner, Rachel, Dantoft, Thomas M., Dauchet, Luc, Davletov, Kairat, De Backer, Guy, De Bacquer, Dirk, de Gaetano, Giovanni, De Henauw, Stefaan, de Oliveira, Paula Duarte, De Smedt, Delphine, Deepa, Mohan, Dehghan, Abbas, Delisle, Hélène, Deschamps, Valérie, Dhana, Klodian, Di Castelnuovo, Augusto F., Dias-da-Costa, Juvenal Soares, Diaz, Alejandro, Dickerson, Ty T., Do, Ha T. 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Donfrancesco, Chiara, Donoso, Silvana P, Döring, Angela, Dorobantu, Maria, Doua, Kouamelan, Drygas, Wojciech, Dulskiene, Virginija, Džakula, Aleksandar, Dzerve, Vilni, Dziankowska-Zaborszczyk, Elzbieta, Eggertsen, Robert, Ekelund, Ulf, El Ati, Jalila, Elliott, Paul, Elosua, Roberto, Erasmus, Rajiv T, Erem, Cihangir, Eriksen, Louise, Eriksson, Johan G, Escobedo-de la Peña, Jorge, Evans, Alun, Faeh, David, Fall, Caroline H, Farzadfar, Farshad, Felix-Redondo, Francisco J, Ferguson, Trevor S, Fernandes, Romulo A, Fernández-Bergés, Daniel, Ferrante, Daniel, Ferrari, Marika, Ferreccio, Catterina, Ferrieres, Jean, Finn, Joseph D, Fischer, Krista, Föger, Bernhard, Foo, Leng Huat, Forslund, Ann-Sofie, Forsner, Maria, Fouad, Heba M, Francis, Damian K, do Carmo Franco, Maria, Franco, Oscar H, Frontera, Guillermo, Fuchs, Flavio D, Fuchs, Sandra C, Fujita, Yuki, Furusawa, Takuro, Gaciong, Zbigniew, Galvano, Fabio, Garcia-de-la-Hera, Manoli, Gareta, Dickman, Garnett, Sarah P, Gaspoz, Jean-Michel, Gasull, Magda, Gates, Louise, Geleijnse, Johanna M, Ghasemian, Anoosheh, Ghimire, Anup, Giampaoli, Simona, Gianfagna, Francesco, Gill, Tiffany K, Giovannelli, Jonathan, Goldsmith, Rebecca A, Gonçalves, Helen, Gonzalez-Gross, Marcela, González-Rivas, Juan P, Gorbea, Mariano Bonet, Gottrand, Frederic, Graff-Iversen, Sidsel, Grafnetter, Dušan, Grajda, Aneta, Grammatikopoulou, Maria G, Gregor, Ronald D, Grodzicki, Tomasz, Grøntved, Ander, Grosso, Giuseppe, Gruden, Gabriella, Grujic, Vera, Gu, Dongfeng, Guan, Ong Peng, Gudmundsson, Elias F, Gudnason, Vilmundur, Guerrero, Ramiro, Guessous, Idri, Guimaraes, Andre L, Gulliford, Martin C, Gunnlaugsdottir, Johanna, Gunter, Marc, Gupta, Prakash C, Gupta, Rajeev, Gureje, Oye, Gurzkowska, Beata, Gutierrez, Laura, Gutzwiller, Felix, Hadaegh, Farzad, Halkjær, Jytte, Hardy, Rebecca, Hari Kumar, Rachakulla, Hata, Jun, Hayes, Alison J, He, Jiang, He, Yuna, Elisabeth, Marleen, Henriques, Ana, Cadena, Leticia Hernandez, Herrala, Sauli, Heshmat, Ramin, Hihtaniemi, Ilpo Tapani, Ho, Sai Yin, Ho, Suzanne C, Hobbs, Michael, Hofman, Albert, Dinc, Gonul Horasan, Horimoto, Andrea R V R, Hormiga, Claudia M, Horta, Bernardo L, Houti, Leila, Howitt, Christina, Htay, Thein Thein, Htet, Aung Soe, Than Htike, Maung Maung, Hu, Yonghua, Huerta, José María, Huisman, Martijn, Husseini, Abdullatif S, Huybrechts, Inge, Hwalla, Nahla, Iacoviello, Licia, Iannone, Anna G, Ibrahim, Mohsen M, Wong, Norazizah Ibrahim, Ikeda, Nayu, Ikram, M Arfan, Irazola, Vilma E, Islam, Muhammad, al-Safi Ismail, Aziz, Ivkovic, Vanja, Iwasaki, Masanori, Jacobs, Jeremy M, Jaddou, Hashem, Jafar, Tazeen, Jamrozik, Konrad, Janszky, Imre, Jasienska, Grazyna, Jelaković, Ana, Jelaković, Bojan, Jennings, Garry, Jeong, Seung-lyeal, Jiang, Chao Qiang, Joffres, Michel, Johansson, Mattia, Jokelainen, Jari J, Jonas, Jost B, Jørgensen, Torben, Joshi, Pradeep, Jóźwiak, Jacek, Juolevi, Anne, Jurak, Gregor, Jureša, Vesna, Kaaks, Rudolf, Kafatos, Anthony, Kajantie, Eero O, Kalter-Leibovici, Ofra, Kamaruddin, Nor Azmi, Karki, Khem B, Kasaeian, Amir, Katz, Joanne, Kauhanen, Jussi, Kaur, Prabhdeep, Kavousi, Maryam, Kazakbaeva, Gyulli, Keil, Ulrich, Boker, Lital Keinan, Keinänen-Kiukaanniemi, Sirkka, Kelishadi, Roya, Kemper, Han C G, Kengne, Andre P, Kerimkulova, Alina, Kersting, Mathilde, Key, Timothy, Khader, Yousef Saleh, Khalili, Davood, Khateeb, Mohammad, Khaw, Kay-Tee, Kiechl-Kohlendorfer, Ursula, Kiechl, Stefan, Killewo, Japhet, Kim, Jeongseon, Kim, Yeon-Yong, Klumbiene, Jurate, Knoflach, Michael, Kolle, Elin, Kolsteren, Patrick, Korrovits, Paul, Koskinen, Seppo, Kouda, Katsuyasu, Kowlessur, Sudhir, Koziel, Slawomir, Kriemler, Susi, Kristensen, Peter Lund, Krokstad, Steinar, Kromhout, Daan, Kruger, Herculina S, Kubinova, Ruzena, Kuciene, Renata, Kuh, Diana, Kujala, Urho M, Kulaga, Zbigniew, Krishna Kumar, R, Kurjata, Pawel, Kusuma, Yadlapalli S, Kuulasmaa, Kari, Kyobutungi, Catherine, Laatikainen, Tiina, Lachat, Carl, Lam, Tai Hing, Landrove, Orlando, Lanska, Vera, Lappas, Georg, Larijani, Bagher, Laugsand, Lars E, Le Nguyen Bao, Khanh, Le, Tuyen D, Leclercq, Catherine, Lee, Jeannette, Lee, Jeonghee, Lehtimäki, Terho, León-Muñoz, Luz M, Levitt, Naomi S, Li, Yanping, Lilly, Christa L, Lim, Wei-Yen, Lima-Costa, M Fernanda, Lin, Hsien-Ho, Lin, Xu, Lind, Lar, Linneberg, Allan, Lissner, Lauren, Litwin, Mieczyslaw, Lorbeer, Roberto, Lotufo, Paulo A, Lozano, José Eugenio, Luksiene, Dalia, Lundqvist, Annamari, Lunet, Nuno, Lytsy, Per, Ma, Guansheng, Ma, Jun, Machado-Coelho, George L L, Machi, Suka, Maggi, Stefania, Magliano, Dianna J, Magriplis, Emmanuella, Majer, Marjeta, Makdisse, Marcia, Malhotra, Rahul, Mallikharjuna Rao, Kodavanti, Malyutina, Sofia, Manios, Yanni, Mann, Jim I, Manzato, Enzo, Margozzini, Paula, Marques-Vidal, Pedro, Marques, Larissa Pruner, Marrugat, Jaume, Martorell, Reynaldo, Mathiesen, Ellisiv B, Matijasevich, Alicia, Matsha, Tandi E, Mbanya, Jean Claude N, Mc Donald Posso, Anselmo J, McFarlane, Shelly R, McGarvey, Stephen T, McLachlan, Stela, McLean, Rachael M, McLean, Scott B, McNulty, Breige A, Mediene-Benchekor, Sounnia, Medzioniene, Jurate, Meirhaeghe, Aline, Meisinger, Christa, Menezes, Ana Maria B, Menon, Geetha R, Meshram, Indrapal I, Metspalu, Andre, Meyer, Haakon E, Mi, Jie, Mikkel, Kairit, Miller, Jody C, Minderico, Cláudia S, Francisco, Juan, Miranda, J Jaime, Mirrakhimov, Erkin, Mišigoj-Durakovic, Marjeta, Modesti, Pietro A, Mohamed, Mostafa K, Mohammad, Kazem, Mohammadifard, Noushin, Mohan, Viswanathan, Mohanna, Salim, Mohd Yusoff, Muhammad Fadhli, Møllehave, Line T, Møller, Niels C, Molnár, Déne, Momenan, Amirabba, Mondo, Charles K, Monyeki, Kotsedi Daniel K, Moon, Jin Soo, Moreira, Leila B, Morejon, Alain, Moreno, Luis A, Morgan, Karen, Moschonis, George, Mossakowska, Malgorzata, Mostafa, Aya, Mota, Jorge, Esmaeel Motlagh, Mohammad, Motta, Jorge, Msyamboza, Kelias P, Mu, Thet Thet, Muiesan, Maria L, Müller-Nurasyid, Martina, Murphy, Neil, Mursu, Jaakko, Musil, Vera, Nabipour, Iraj, Nagel, Gabriele, Naidu, Balkish M, Nakamura, Harunobu, Námešná, Jana, Nang, Ei Ei K, Nangia, Vinay B, Narake, Sameer, Nauck, Matthia, Navarrete-Muñoz, Eva Maria, Ndiaye, Ndeye Coumba, Neal, William A, Nenko, Ilona, Neovius, Martin, Nervi, Flavio, Nguyen, Chung T, Nguyen, Nguyen D, Nguyen, Quang Ngoc, Nguyen, Quang V, Nieto-Martínez, Ramfis E, Niiranen, Teemu J, Ning, Guang, Ninomiya, Toshiharu, Nishtar, Sania, Noale, Marianna, Noboa, Oscar A, Noorbala, Ahmad Ali, Norat, Teresa, Noto, Davide, Al Nsour, Mohannad, O'Reilly, Dermot, Oda, Eiji, Oehlers, Glenn, Oh, Kyungwon, Ohara, Kumiko, Olinto, Maria Teresa A, Oliveira, Isabel O, Omar, Mohd Azahadi, Onat, Altan, Ong, Sok King, Ono, Lariane M, Ordunez, Pedro, Ornelas, Rui, Osmond, Clive, Ostojic, Sergej M, Ostovar, Afshin, Otero, Johanna A, Overvad, Kim, Owusu-Dabo, Elli, Paccaud, Fred Michel, Padez, Cristina, Pahomova, Elena, Pajak, Andrzej, Palli, Domenico, Palmieri, Luigi, Pan, Wen-Harn, Panda-Jonas, Songhomitra, Panza, Francesco, Papandreou, Dimitrio, Park, Soon-Woo, Parnell, Winsome R, Parsaeian, Mahboubeh, Patel, Nikhil D, Pecin, Ivan, Pednekar, Mangesh S, Peer, Nasheeta, Peeters, Petra H, Peixoto, Sergio Viana, Peltonen, Markku, Pereira, Alexandre C, Peters, Annette, Petersmann, Astrid, Petkeviciene, Janina, Pham, Son Thai, Pigeot, Iri, Pikhart, Hynek, Pilav, Aida, Pilotto, Lorenza, Pitakaka, Freda, Piwonska, Aleksandra, Plans-Rubió, Pedro, Polašek, Ozren, Porta, Miquel, Portegies, Marileen L P, Pourshams, Akram, Poustchi, Hossein, Pradeepa, Rajendra, Prashant, Mathur, Price, Jacqueline F, Puder, Jardena J, Puiu, Maria, Punab, Margu, Qasrawi, Radwan F, Qorbani, Mostafa, Bao, Tran Quoc, Radic, Ivana, Radisauskas, Ricarda, Rahman, Mahfuzar, Raitakari, Olli, Raj, Manu, Ramachandra Rao, Sudha, Ramachandran, Ambady, Ramos, Elisabete, Rampal, Lekhraj, Rampal, Sanjay, Rangel Reina, Daniel A, Redon, Josep, Reganit, Paul Ferdinand M, Ribeiro, Robespierre, Riboli, Elio, Rigo, Fernando, Rinke de Wit, Tobias F, Ritti-Dias, Raphael M, Robinson, Sian M, Robitaille, Cynthia, Rodríguez-Artalejo, Fernando, del Cristo Rodriguez-Perez, María, Rodríguez-Villamizar, Laura A, Rojas-Martinez, Rosalba, Romaguera, Dora, Ronkainen, Kimmo, Rosengren, Annika, Roy, Joel G R, Rubinstein, Adolfo, Sandra Ruiz-Betancourt, Blanca, Rutkowski, Marcin, Sabanayagam, Charumathi, Sachdev, Harshpal S, Saidi, Olfa, Sakarya, Sibel, Salanave, Benoit, Salazar Martinez, Eduardo, Salmerón, Diego, Salomaa, Veikko, Salonen, Jukka T, Salvetti, Massimo, Sánchez-Abanto, Jose, Sans, Susana, Santos, Diana A, Santos, Ina S, Nunes dos Santos, Renata, Santos, Rute, Saramies, Jouko L, Sardinha, Luis B, Sarganas, Giselle, Sarrafzadegan, Nizal, Saum, Kai-Uwe, Savva, Savva, Scazufca, Marcia, Schargrodsky, Herman, Schipf, Sabine, Schmidt, Carsten O, Schöttker, Ben, Schultsz, Constance, Schutte, Aletta E, Sein, Aye Aye, Sen, Abhijit, Senbanjo, Idowu O, Sepanlou, Sadaf G, Sharma, Sanjib K, Shaw, Jonathan E, Shibuya, Kenji, Shin, Dong Wook, Shin, Youchan, Si-Ramlee, Khairil, Siantar, Rosalynn, Sibai, Abla M, Santos Silva, Diego Augusto, Simon, Mary, Simons, Judith, Simons, Leon A, Sjöström, Michael, Skovbjerg, Sine, Slowikowska-Hilczer, Jolanta, Slusarczyk, Przemyslaw, Smeeth, Liam, Smith, Margaret C, Snijder, Marieke B, So, Hung-Kwan, Sobngwi, Eugène, Söderberg, Stefan, Solfrizzi, Vincenzo, Sonestedt, Emily, Song, Yi, Sørensen, Thorkild I A, Soric, Maroje, Jérome, Charles Sossa, Soumare, Aicha, Staessen, Jan A, Stathopoulou, Maria G, Stavreski, Bill, Steene-Johannessen, Jostein, Stehle, Peter, Stein, Aryeh D, Stergiou, George S, Stessman, Jochanan, Stieber, Jutta, Stöckl, Dori, Stocks, Tanja, Stokwiszewski, Jakub, Stronks, Karien, Strufaldi, Maria Wany, Sun, Chien-An, Sung, Yn-Tz, Suriyawongpaisal, Paibul, Sy, Rody G, Shyong Tai, E, Tammesoo, Mari-Lii, Tamosiunas, Abdona, Tan, Eng Joo, Tang, Xun, Tanser, Frank, Tao, Yong, Tarawneh, Mohammed Rasoul, Tarqui-Mamani, Carolina B, Tautu, Oana-Florentina, Taylor, Anne, Theobald, Holger, Theodoridis, Xenophon, Thijs, Lutgarde, Thuesen, Betina H, Tjonneland, Anne, Tolonen, Hanna K, Tolstrup, Janne S, Topbas, Murat, Topór-Madry, Roman, Tormo, María José, Torrent, Matie, Traissac, Pierre, Trichopoulos, Dimitrio, Trichopoulou, Antonia, Trinh, Oanh T H, Trivedi, Atul, Tshepo, Lechaba, Tulloch-Reid, Marshall K, Tullu, Fikru, Tuomainen, Tomi-Pekka, Tuomilehto, Jaakko, Turley, Maria L, Tynelius, Per, Tzourio, Christophe, Ueda, Peter, Ugel, Eunice E, Ulmer, Hanno, Uusitalo, Hannu M T, Valdivia, Gonzalo, Valvi, Damaskini, van der Schouw, Yvonne T, Van Herck, Koen, Van Minh, Hoang, van Rossem, Lenie, Van Schoor, Natasja M, van Valkengoed, Irene G M, Vanderschueren, Dirk, Vanuzzo, Diego, Vatten, Lar, Vega, Toma, Velasquez-Melendez, Gustavo, Veronesi, Giovanni, Monique Verschuren, W M, Verstraeten, Roosmarijn, Victora, Cesar G, Viet, Lucie, Viikari-Juntura, Eira, Vineis, Paolo, Vioque, Jesu, Virtanen, Jyrki K, Visvikis-Siest, Sophie, Viswanathan, Bharathi, Vlasoff, Tiina, Vollenweider, Peter, Voutilainen, Sari, Wade, Alisha N, Wagner, Aline, Walton, Janette, Wan Bebakar, Wan Mohamad, Wan Mohamud, Wan Nazaimoon, Wanderley, Rildo S, Wang, Ming-Dong, Wang, Qian, Wang, Ya Xing, Wang, Ying-Wei, Wannamethee, S Goya, Wareham, Nichola, Wedderkopp, Niel, Weerasekera, Deepa, Whincup, Peter H, Widhalm, Kurt, Widyahening, Indah S, Wiecek, Andrzej, Wijga, Alet H, Wilks, Rainford J, Willeit, Johann, Willeit, Peter, Williams, Emmanuel A, Wilsgaard, Tom, Wojtyniak, Bogdan, Wong-McClure, Roy A, Wong, Justin Y Y, Wong, Tien Yin, Woo, Jean, Giwercman Wu, Aleksander, Wu, Frederick C, Wu, Shouling, Xu, Haiquan, Yan, Weili, Yang, Xiaoguang, Ye, Xingwang, Yiallouros, Panayiotis K, Yoshihara, Akihiro, Younger-Coleman, Novie O, Yusoff, Ahmad Faudzi, Zainuddin, Ahmad Ali, Zambon, Sabina, Zampelas, Antoni, Zdrojewski, Tomasz, Zeng, Yi, Zhao, Dong, Zhao, Wenhua, Zheng, Wei, Zheng, Yingfeng, Zhu, Dan, Zhussupov, Baurzhan, Zimmermann, Esther, Cisneros, Julio Zuñiga, The State Key Laboratory of Cell Biology [Shanghai, China] (CAS Center for Excellence in Molecular Cell Science), Shanghai Institute of Biochemistry and Cell Biology [Shanghai, China]-University of Chinese Academy of Sciences [Shanghai, China], Imperial College London, University of Kentucky, Middlesex University, Cleveland Clinic, Universidad Peruana Cayetano Heredia (UPCH), Brandeis University, Mulago Hospital [Kampala, Ouganda], Department of Epidemiology and Public Health, Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), World Health Organisation (WHO), Al-Quds University, Discipline of Medicine, University of South Australia [Adelaide], Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán - National Institute of Medical Science and Nutrition Salvador Zubiran [Mexico], Leibniz Institute for Prevention Research and Epidemiology - BIPS, Leibniz Association, Centre for Industrial Management, Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Epidémiologie des maladies chroniques : impact des interactions gène environnement sur la santé des populations, Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé, Institute of Preventive Medicine, Copenhagen University Hospitals, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Dept. Atherosclerose, University of Iceland [Reykjavik], Institute for Biotechnology and Bioengineering (IBB), Technical University of Lisbon, Medical University of Łódź (MUL), Department of Preventive Medicine and Public Health, Universidad Autónoma de Madrid (UAM), Faculté de Médecine de Tunis, Université de Tunis El Manar (UTM), Sunder Lal Jain Hospital, Ufa Eye Research Institute [Bashkortostan], National Institute of Public Health, Department of Epidemiology, Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke (DifE), Leibniz Association-Leibniz Association, CHU Toulouse [Toulouse], Institute of Social and Preventive Medicine, Lausanne university hospital, Division of Clinical Epidemiology and Aging Research, German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), Department of Medical Sciences [Turin, Italy] (DMS), Università degli studi di Torino = University of Turin (UNITO), ASU - School for Engineering of Matter, Transport and Energy, Arizona State University [Tempe] (ASU), Universidade do Porto = University of Porto, University of Oxford [Oxford], Cancer & Radiation Epidemiology Unit, Gertner Institute, Chaim Sheba Medical Center, Consorcio de Investigación Biomédica en Red especializado en Epidemiología y Salud Pública (CIBERESP), Los Centros de Investigación Biomédica en Red (CIBER), 2nd Department of Internal Medicine, Molecular Medicine, Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven)-IRC KULAK, Department of Public Health, State University of Ghent, MRC Lifecourse Epidemiology Unit [Southampton, UK], University of Southampton, Réseau International des Instituts Pasteur (RIIP), Institute of Epidemiology [Neuherberg] (EPI), German Research Center for Environmental Health - Helmholtz Center München (GmbH), Sahlgrenska University Hospital [Gothenburg], Institute of Metabolic Science, MRC, Institut National de Nutrition et de Technologie Alimentaire (INNTA), University of Huddersfield, IMIM-Hospital del Mar, Generalitat de Catalunya, Medstar Research Institute, Queen's University [Belfast] (QUB), Medical Research Council, Applied Sciences, National Research Institute on Food and Nutrition, Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps (LEASP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Infectious diseases division, Department of internal medicine, Washington University in Saint Louis (WUSTL), Innsbruck Medical University [Austria] (IMU), Department of Epidemiology [Rotterdam], Erasmus University Medical Center [Rotterdam] (Erasmus MC), Laboratoire d'Etude des Mammifères Marins (LEMM), Océanopolis [Brest], Faculté de Médecine Henri Warembourg - Université de Lille, Institute of Sport Science and Clinical Biomechanics, University of Southern Denmark (SDU), Icelandic Heart Association, Heart Preventive Clinic and Research Institute, Centro Investig Quim Aplicada, Coahuila, Mexico, Centro Investigacion en Quimica Aplicada, Coahuila, Mexico, University of Geneva [Switzerland], Department of Civil Engineering [Hamirpur], National Institute of Technology [Hamirpur], Health Services Research Unit, Danish Cancer Society, Institute of Cancer Epidemiology, London School of Hygiene and Tropical Medicine (LSHTM), University College of London [London] (UCL), The Georges Institute for International Health, The University of Sydney, School of Information Technology, Deakin University Waurn Ponds, Faculté de Médecine, Université Djilali Liabès [Sidi-Bel-Abbès], Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), CIBER de Epidemiología y Salud Pública (CIBERESP), VU University Medical Center [Amsterdam], Universiteit Gent = Ghent University [Belgium] (UGENT), Faculty of Agricultural and Food Science, American University of Beirut [Beyrouth] (AUB), Åbo Akademi University [Turku], Department of Public Health Sciences, Karolinska Institutet [Stockholm], Great Lakes Institute for Environmental Research, University of Windsor [Ca], Universität Heidelberg [Heidelberg], Research Center for Prevention and Health, University of Ljubljana, Division of Cancer Epidemiology, University of Crete School of medicine, School of Public Health and Clinical Nutrition, University of Eastern Finland, Institute of Epidemiology and Social Medicine, Westfälische Wilhelms-Universität Münster = University of Münster (WWU), Research Institute of Child Nutrition Dortmund, Rheinische Friedrich-Wilhelms-Universität Bonn, Cancer Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge [UK] (CAM), Department of Oncology, University of Tampere Medical School, University of Tampere, Wageningen University and Research [Wageningen] (WUR), Centre for Environmental Health, National Institue of Public Health, School of Public Health, The University of Hong Kong (HKU), Tehran University of Medical Sciences, Istituto Nazionale di Ricerca per gli Alimenti e la Nutrizione (INRAN), INRAN, National University of Singapore (NUS), Faculty of Medicine and Life Sciences [Tampere], University of Tampere [Finland], Centre Européen de Réalité Virtuelle (CERV), École Nationale d'Ingénieurs de Brest (ENIB), Uppsala Universitet [Uppsala], Department of Public Health and Community Medicine, University of Gothenburg (GU), Institute of Earthquake Science, CEA, Beijing, CEA, Beijing, University of Porto Medical School, Laboratoire de Chimie Physique D'Orsay (LCPO), Université Paris-Sud - Paris 11 (UP11)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Aging Program, National research council, Padua, Italy, Baker IDI Heart and Diabetes Institute, Institute of Internal Medicine, Russian Academy of Medical Sciences, Department of Nutrition and Dietetics, Harokopio University, Emory University [Atlanta, GA], Départment of Biotechnology, Faculty of Science, University of Oran Es-Senia [Oran] | Université d'Oran Es-Senia [Oran], Institut National de la Santé et de la Recherche Médicale (INSERM), University of Tartu, Department of Community, Université Ain Shams-Faculty of Medicine-Environmental and Occupational Medicine, Pécsi Tudemányegyetem, Department of Community, Environmental and Occupational Medicine, Université Ain Shams, Research Centre in Physical Activity, Health and Leisure, Nutrition and Metabolism Section, International Agency for Research on Cancer, Bushehr University of Medical Sciences, Institute of Epidemiology and Medical Biometry [Ulm, Allemagne], Universität Ulm - Ulm University [Ulm, Allemagne], Università degli studi di Palermo - University of Palermo, MRc Environmental Epidemiology Unit, Department of Cardiology and Department of Clinical Epidemiology, Aarhus University Hospital, Kumasi Centre for Collaborative Research in Tropical Medicine (KCCR), Department of Epidemiology and Population Studies, Jagiellonian University, Uniwersytet Jagielloński w Krakowie = Jagiellonian University (UJ), Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute – ISPO, Social Robotics Laboratory, University of Freiburg, Freiburg im Breisgau, Department of Ophthalmology, Universitätsklinikum Mannheim, Medizinische Fakultät Mannheim der Universität Heidelberg, University of Bari Aldo Moro (UNIBA), Department of Cardiology, Eastbourne General Hospital, Julius Center for Health Sciences and Primary Care, University Medical Center [Utrecht], Laboratoire d'Innovation pour les Technologies des Energies Nouvelles et les nanomatériaux (LITEN), Institut National de L'Energie Solaire (INES), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), King‘s College London, Public Health Sciences, University of Edinburgh, Movement Disorders and Tourette Centre, Genetica medicala, Victor Babeş University of Medicine and Pharmacy (UMFT), Andrology Unit, United Laboratories of Tartu University Clinics, Tampere University Hospital, Department of Hygiene and Epidemiology, Dept of Epidemiology and Public Health, Department of Epidemiology and Biostatistics, Imperial College London-School of public health, The University of Hong Kong (HKU)-The University of Hong Kong (HKU), Department of Emergency and Cardiovascular Medicine, Sahlgrenska Academy, Institut de Veille Sanitaire (INVS), Department of Epidemiology, Murcia Regional Health Council, Murcia, Spain, parent, Department of Chronic Disease Prevention, National Institute for Health and Welfare [Helsinki], University of São Paulo (USP), Institut de Recherche pour le Développement (IRD [France-Sud]), Institute for plasma research, Institute for Plasma Research, Department of Biosciences and Nutrition, Department of Reproductive Endocrinology, Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam UMC - Academic medical center, Central Hospital and Faculty of medicine and biomedical sciences university, University of Yaoundé [Cameroun], Department of Clinical Sciences, Lund University [Lund]-Lund University Diabetes Centre, School of Computing [Leeds], University of Leeds, Copenhagen University Hospital, Neuroépidémiologie, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Maastricht University [Maastricht], Interactions Gène-Environnement en Physiopathologie Cardio-Vasculaire (IGE-PCV), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Applied Food Science, Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, University of Amsterdam, Dept. of Social Medecine, Department of Medical Sciences and Uppsala Clinical Research Center, Uppsala University Hospital, Africa Centre for Health and Population Studies, University of KwaZulu-Natal [Durban, Afrique du Sud] (UKZN)-Medical Research Council of South Africa, Center for Family and Community Medicine, Department of Neurobiology, Care Sciences and Society, Department of Cardiovascular Sciences [Leuven], Cancer Epidemiology Institute, Department of Epidemiology and Health Promotion (MONICA Data Centre), National Public Health Institute, Nutrition et Alimentation des Populations aux Suds (NutriPass), Université Montpellier 1 (UM1)-Institut de Recherche pour le Développement (IRD)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université de Montpellier (UM)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Havard School of Public Health, Dept of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School [Athens], University of Kuopio, Tampere University, University Medical Centre Utrecht, Department of Social Medicine, Amsterdam, Center for Metabolic Bone Diseases, Catholic University of Leuven, Norwegian University of Science and Technology [Trondheim] (NTNU), Norwegian University of Science and Technology (NTNU), Universidad Miguel Hernández [Elche] (UMH), Institute of Public Health and Clinical Nutrition [Kuopio, Finland], Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois [Lausanne] (CHUV), Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg (UNISTRA), Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Division of Community Health Sciences, St George's University of London, Medizinische Universität Wien = Medical University of Vienna, Medical University of Silesia (SUM), National Institute for Public Health and the Environment [Bilthoven] (RIVM), University of Innsbruck, National Institute of Hygiene Warsaw, Johns Hopkins University School of Medicine [Baltimore], Food Science and Technology, Beijing Forestry University, College of Automation Engineering, Nanjing University of Aeronautics and Astronautics (CAE-NUAA), NUAA, Chinese Center for Disease Control and Prevention, Department of Applied Mathematics, School of Science, Northwestern Polytechnical University, Xi’an, Shaanxi 710072, Siemens Corporate Research, Siemens AG [Munich], Franche-Comté Électronique Mécanique, Thermique et Optique - Sciences et Technologies (UMR 6174) (FEMTO-ST), Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), This work was supported by the Wellcome Trust [101506/Z/13/Z]., NCD Risk Factor Collaboration (NCD-RisC). We thank WHO country and regional offices and the World Heart Federation for support in data identification and access., Universidad Autonoma de Madrid (UAM), University of Turin, Universidade do Porto, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Université Lille 2 - Faculté de Médecine, Westfälische Wilhelms-Universität Münster (WWU), Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), University of KwaZulu-Natal (UKZN)-Medical Research Council of South Africa, Institut de Recherche pour le Développement (IRD)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Université de Montpellier (UM), Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS), Lund University Diabetes Centre-Lund University [Lund], Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Medical University of Silesia, Katowice, Apollo - University of Cambridge Repository, University of Kentucky (UK), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Lausanne University Hospital, University of Oxford, Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Innsbruck Medical University = Medizinische Universität Innsbruck (IMU), Université de Genève = University of Geneva (UNIGE), Deakin University [Waurn Ponds], Universiteit Gent = Ghent University (UGENT), Universität Heidelberg [Heidelberg] = Heidelberg University, Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro (UNIBA), Universidade de São Paulo = University of São Paulo (USP), Lund University [Lund], Laboratoire Chrono-environnement (UMR 6249) (LCE), Leopold Franzens Universität Innsbruck - University of Innsbruck, National Institute of Public Health - National Institute of Hygiene [Poland], Yiallouros, Panayiotis K. [0000-0002-8339-9285], Giampaoli, Simona [0000-0002-6679-1488], Moschonis, George [0000-0003-3009-6675], Papandreou, Dimitrios [0000-0002-4923-484X], Stathopoulou, Maria G. [0000-0003-4376-2083], Stergiou, George S. [0000-0002-6132-0038], Trichopoulou, Antonia [0000-0002-7204-6396], Valvi, Damaskini [0000-0003-4633-229X], Chen, Z, Woodward, M, Key, T, and Smith, M
Subjects: systolic blood pressure, Settore MED/09 - Medicina Interna, blood pressure measurement, HEALTH EXAMINATION SURVEYS, Blood Pressure, Hypertension, Population Health, Global Health, Non-communicable Disease, Epidemiology, [SDV]Life Sciences [q-bio], global health, South Asia, purl.org/pe-repo/ocde/ford#3.03.09 [https], kohonnut verenpaine, Medicine and Health Sciences, middle income country, measurement method, skin and connective tissue diseases, VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771, Public, Environmental & Occupational Health, adult, Population health, public health, blood pressure regulation, Public Health, Global Health, Social Medicine and Epidemiology, Non-communicable disease, kansainvälinen vertailu, health survey, aged, female, priority journal, Blood pressure, mean arterial pressure, GLOBAL TRENDS, SODIUM-INTAKE, Life Sciences & Biomedicine, survey design, hypertension, prevalence, Global health, UNITED-STATES, URBAN COMMUNITIES, Article, SECULAR TRENDS, Middle East, Central Asia, male, disease prevalence, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, kansanterveys, blood, SYSTEMATIC ANALYSIS, human, verenpainetauti, non-communicable disease, Science & Technology, Pacific Ocean, high income country, diastolic blood pressure, Pacific Rim, Blood Pressure - Epidemiology - Population, North Africa, major clinical study, HYPERTENSION PREVALENCE, verenpaine, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, ARTERIAL-HYPERTENSION, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, POTASSIUM INTAKE, sense organs, trend analysis, trend study, population research, population health, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, low income country
Abstract: Background: Change in the prevalence of raised blood pressure could be due to both shifts in the entire distribution of blood pressure (representing the combined effects of public health interventions and secular trends) and changes in its high-blood-pressure tail (representing successful clinical interventions to control blood pressure in the hypertensive population). Our aim was to quantify the contributions of these two phenomena to the worldwide trends in the prevalence of raised blood pressure. Methods: We pooled 1018 population-based studies with blood pressure measurements on 88.6 million participants from 1985 to 2016. We first calculated mean systolic blood pressure (SBP), mean diastolic blood pressure (DBP) and prevalence of raised blood pressure by sex and 10-year age group from 20-29 years to 70-79 years in each study, taking into account complex survey design and survey sample weights, where relevant. We used a linear mixed effect model to quantify the association between (probit-transformed) prevalence of raised blood pressure and age-group-and sex-specific mean blood pressure. We calculated the contributions of change in mean SBP and DBP, and of change in the prevalence-mean association, to the change in prevalence of raised blood pressure. Results: In 2005-16, at the same level of population mean SBP and DBP, men and women in South Asia and in Central Asia, the Middle East and North Africa would have the highest prevalence of raised blood pressure, and men and women in the high-income Asia Pacific and high-income Western regions would have the lowest. In most region-sex-age groups where the prevalence of raised blood pressure declined, one half or more of the decline was due to the decline in mean blood pressure. Where prevalence of raised blood pressure has increased, the change was entirely driven by increasing mean blood pressure, offset partly by the change in the prevalence-mean association. Conclusions: Change in mean blood pressure is the main driver of the worldwide change in the prevalence of raised blood pressure, but change in the high-blood-pressure tail of the distribution has also contributed to the change in prevalence, especially in older age groups., This work was supported by the Wellcome Trust [101506/Z/13/Z].
Published: 2018

48. Burden of Metastatic Castrate Naive Prostate Cancer Patients, to Identify Men More Likely to Benefit from Early Docetaxel: Further Analyses of CHAARTED and GETUG-AFU15 Studies

Author: Florence Joly, Muriel Habibian, Manish Kohli, Jean Marie Boher, Christopher Sweeney, Jorge A. Garcia, Glenn Liu, Gwenaelle Gravis, Joel Picus, Mario J. Eisenberger, Michel Soulié, David M. Jarrard, Maha Hussain, Michael A. Carducci, Karim Fizazi, Nicholas J. Vogelzang, Robert Dreicer, Stéphane Oudard, Yu-Hui Chen, Robert S. DiPaola, Centre de Recherche en Cancérologie de Marseille (CRCM), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Aix Marseille Université (AMU), Unité de Biostatistiques [Institut Paoli-Calmettes] (Département de la Recherche clinique et de l'Innovation), Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC), ECOG-ACRIN Biostatistics Center [Boston, MA, USA], Dana-Farber Cancer Institute [Boston], Carbone Cancer Center [Madison, WI, USA], University of Wisconsin-Madison, Département de médecine oncologique [Gustave Roussy], Institut Gustave Roussy (IGR), Johns Hopkins University (JHU), Service d'oncologie médicale [CHU HEGP], Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Service d'oncologie génétique [Caen] (Centre François Baclesse), Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU), Service d'Urologie - Transplantation Rénale - Andrologie, CHU Toulouse [Toulouse]-Hôpital de Rangueil, CHU Toulouse [Toulouse], UNICANCER [Paris], Fédération nationale des Centres de lutte contre le Cancer (FNCLCC), University of Virginia [Charlottesville, VA, USA], Cleveland Clinic, Comprehensive Cancer [Ann Arbor, MI, USA], University of Michigan [Ann Arbor], University of Michigan System-University of Michigan System, Mayo Clinic [Rochester, MN, USA], Mayo Clinic [Rochester], Nevada Cancer Research Foundation, Saint Louis University (SLU), College of Medicine [Lexington, KY, USA], University of Kentucky, Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Service d'Oncologie médicale [CHU Caen], CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Département d'Urologie-Andrologie et Transplantation Rénale [CHU Toulouse], Pôle Urologie - Néphrologie - Dialyse - Transplantations - Brûlés - Chirurgie plastique - Explorations fonctionnelles et physiologiques [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), University of Kentucky (UK), and Dupuis, Christine
Subjects: Oncology, Male, medicine.medical_specialty, Urology, 030232 urology & nephrology, Bone Neoplasms, [SDV.CAN]Life Sciences [q-bio]/Cancer, Disease, Docetaxel, Metastatic castrate naive prostate cancer, Androgen deprivation therapy, Metastasis, Gonadotropin-Releasing Hormone, 03 medical and health sciences, Prostate cancer, Metastatic prostate cancer, 0302 clinical medicine, High volume, [SDV.CAN] Life Sciences [q-bio]/Cancer, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, medicine, Clinical endpoint, Humans, Chemotherapy, Neoplasm Metastasis, Low volume, Aged, Randomized Controlled Trials as Topic, business.industry, Hazard ratio, Prostatic Neoplasms, Androgen Antagonists, Middle Aged, medicine.disease, Prognosis, Confidence interval, 3. Good health, Tumor Burden, Survival Rate, Clinical Trials, Phase III as Topic, 030220 oncology & carcinogenesis, Volume disease, business, Orchiectomy, medicine.drug
Abstract: International audience; BACKGROUND:Docetaxel (D) at the time of starting androgen deprivation therapy (ADT) for metastatic castrate naive prostate cancer shows a clear survival benefit for patients with high-volume (HV) disease. It is unclear whether patients with low-volume (LV) disease benefit from early D.OBJECTIVE:To define the overall survival (OS) of aggregate data of patient subgroups from the CHAARTED and GETUG-AFU15 studies, defined by metastatic burden (HV and LV) and time of metastasis occurrence (at diagnosis or after prior local treatment [PRLT]).DESIGN, SETTING, AND PARTICIPANTS:Data were accessed from two independent phase III trials of ADT alone or ADT+D-GETUG-AFU15 (N=385) and CHAARTED (N=790), with median follow-ups for survivors of 83.2 and 48.2 mo, respectively. The definition of HV and LV disease was harmonized.OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS:The primary end point was OS.RESULTS AND LIMITATIONS:Meta-analysis results of the aggregate data showed significant heterogeneity in ADT+D versus ADT effect sizes between HV and LV subgroups (p=0.017), and failed to detect heterogeneity in ADT+D versus ADT effect sizes between upfront and PRLT subgroups (p=0.4). Adding D in patients with HV disease has a consistent effect in improving median OS (HV-ADT: 34.4 and 35.1 mo, HV-ADT+D: 51.2 and 39.8 mo in CHAARTED and GETUG-AFU15, respectively; pooled average hazard ratio or HR (95% confidence interval [CI]) 0.68 ([95% CI 0.56; 0.82], p
Published: 2018

49. Reconstructing deep-time palaeoclimate legacies in the clusioid Malpighiales unveils their role in the evolution and extinction of the boreotropical flora

Author: Charles C. Davis, Jorge M. Lobo, David J. Beerling, Josselin Cornuault, Isabel Sanmartín, Brad R. Ruhfel, Emmanuelle Jousselin, Andrea S. Meseguer, Centre de Biologie pour la Gestion des Populations (UMR CBGP), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Université de Montpellier (UM)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Institut des Sciences de l'Evolution de Montpellier (UMR ISEM), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS), Department of Animal and Plant Sciences, University of Sheffield [Sheffield], University of Kentucky, Harvard University [Cambridge], European Project: 267196,EC:FP7:PEOPLE,FP7-PEOPLE-2010-COFUND,AGREENSKILLS(2012), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École Pratique des Hautes Études (EPHE), University of Kentucky (UK), Harvard University, Ministerio de Economía y Competitividad (España), European Commission, Agence Nationale de la Recherche (France), Sánchez Meseguer, Andrea [0000-0003-0743-404X], Sanmartin Bastida, Isabel [0000-0001-6104-9658], Sánchez Meseguer, Andrea, and Sanmartin Bastida, Isabel
Subjects: 0106 biological sciences, 0301 basic medicine, Niche evolution, Boreotropical flora, Diversification (marketing strategy), 010603 evolutionary biology, 01 natural sciences, Climate cooling, 03 medical and health sciences, [SDV.BV]Life Sciences [q-bio]/Vegetal Biology, Ecology, Evolution, Behavior and Systematics, Deep time, Global and Planetary Change, Extinction, Ecology, biology, Fossils, 15. Life on land, biology.organism_classification, Malpighiales, 030104 developmental biology, Geography, 13. Climate action, Diversification, Hypericum
Abstract: Aim: During its entire history, the Earth has gone through periods of climate change similar in scale and pace to the warming trend observed today in the Anthropocene. The impact of these ancient climatic events on the evolutionary trajectories of organisms provides clues on the organismal response to climate change, including extinction, migration and persistence. Here, we examine the evolutionary response to climate cooling/warming events of the clusioid families Calophyllaceae, Podostemaceae and Hypericaceae (CPH clade) and the genus Hypericum as test cases. Location: Holarctic. Time period: Late Cretaceous–Cenozoic. Major taxa studied: Angiosperms. Methods: We use palaeoclimate simulations, species distribution models and phylogenetic com- parative approaches calibrated with fossils. Results: Ancestral CPH lineages could have been distributed in the Holarctic 100 Ma, occupying tropical subhumid assemblages, a finding supported by the fossil record. Expansion to closed- canopy tropical rain forest habitats occurred after 60 Ma, in the Cenozoic, in agreement with ear- lier ideas of a post-Cretaceous origin of current tropical rain forest. Posterior Cooling during the Eocene triggered diversification declines in CPH tropical lineages, and was associated with a cli- matic shift towards temperate affinities in Hypericum. Hypericum subsequently migrated to tropical mountains, where it encountered different temperate conditions than in the Holarctic. Main conclusions: We hypothesize that most clusioid CPH lineages failed to adapt to temperate regimes during periods of Cenozoic climate change, and went extinct in the Holarctic. In contrast, boreotropical descendants including Hypericum that underwent niche evolution demonstrated selective advantages as climates became colder. Our results point toward macroevolutionary tra- jectories involving the altering fates of closely related clades that adapt to periods of global climate change versus those that do not. Moreover, they suggest the hypothesis that potentially many clades, particularly inhabitants of boreotropical floras, were likely extirpated from the Holarctic and persist today (if at all) in more southern tropical locations., Spanish Government: Grant Numbers: PhD Fellowship: AP‐2007‐01698, Projects CGL2009‐13322‐C01 , CGL2011‐25544 , CGL2012‐40129‐C01 , CGL2015‐67849‐P (MINECO/FEDER)., Marie‐Curie FP7–COFUND (AgreenSkills Fellowship–26719), Agence Nationale de la Recherche (CEBA, ref. ANR-10-LABX-25- 01), Marie-Curie Actions People H2020 (MSCA- IF-EF-ST-708207)
Published: 2018

50. Chemical states of surface oxygen during CO oxidation on Pt(1 1 0) surface revealed by ambient pressure XPS

Author: Kazuhisa Isegawa, Jean Jacques Gallet, Philip N. Ross, Daehyun Kim, Hojoon Lim, Bongjin Simon Mun, Kazuhiko Mase, Youngseok Yu, Hiroshi Kondoh, Kohei Ueda, Ethan J. Crumlin, Beomgyun Jeong, Fabrice Bournel, Yoobin Esther Koh, Gwangju Institute of Science and Technology (GIST), University of Kentucky (UK), Keio University, KEK (High energy accelerator research organization), Laboratoire de Chimie Physique - Matière et Rayonnement (LCPMR), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Exothermic reaction, Photoemission spectroscopy, Diffusion, Fluids & Plasmas, Inorganic chemistry, Oxide, Analytical chemistry, chemistry.chemical_element, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Oxygen, chemistry.chemical_compound, X-ray photoelectron spectroscopy, [CHIM]Chemical Sciences, Nanotechnology, General Materials Science, [PHYS]Physics [physics], [CHIM.MATE]Chemical Sciences/Material chemistry, Materials Engineering, 021001 nanoscience & nanotechnology, Condensed Matter Physics, 0104 chemical sciences, Chemical state, chemistry, [PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci], 0210 nano-technology, Ambient pressure
Abstract: The study of CO oxidation on Pt(1 1 0) surface is revisited using ambient pressure x-ray photoemission spectroscopy. When the surface temperature reaches the activation temperature for CO oxidation under elevated pressure conditions, both the α-phase of PtO2 oxide and chemisorbed oxygen are formed simultaneously on the surface. Due to the exothermic nature of CO oxidation, the temperature of the Pt surface increases as CO oxidation takes place. As the CO/O2 ratio increases, the production of CO2 increases continuously and the surface temperature also increases. Interestingly, within the diffusion limited regions, the amount of surface oxide changes little while the chemisorbed oxygen is reduced.
Published: 2017

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