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4,766 results on '"University of Kent [Canterbury]"'

1. Para Repensar o Trabalho do Ator: algumas considerações improvisadas e provisórias sobre a atuação hoje

Author: Patrice Pavis (University of Kent, Canterbury – Reino Unido)
Subjects: Atuação, Encenação, Treinamento do Ator, Pós-dramático, Teatro, Drama, PN1600-3307, Dramatic representation. The theater, PN2000-3307
Abstract: Este artigo retoma algumas ideias apresentadas durante a conferência Acting Reconsidered. O estudo do ator em performances contemporâneas deveria ser reavaliado à luz de experiências dos últimos cinquenta anos, particularmente a arte da performance, o teatro pós-dramático, o teatro interativo e muitos teatros políticos. Apresentam-se novas tarefas e concepções de ator. Questiona-se a noção de realismo psicológico de Stanislavski. A sugestão de desdramatizar, deslocalizar, destreinar o ator pode ajudá-lo a orientar-se no mundo.
Published: 2015

2. Reconsidering Acting: a few improvised and provisory thoughts on acting today

Author: Patrice Pavis (University of Kent, Canterbury – United Kingdom)
Subjects: Acting, Staging, Actor’s Training, Post-dramatic, Theatre, Drama, PN1600-3307, Dramatic representation. The theater, PN2000-3307
Abstract: This paper summarizes my thoughts during the presentation of the conference Acting reconsidered. The study of the actor in contemporary performances should be reevaluated in the light of the experiments of the last fifty years, particularly performance art, post-dramatic theatre, participative theatre and many political theatre. The new tasks and conceptions of the actor are introduced. Stanislavki’s notion of psychological realism is questioned. The suggestion of de-dramatizing, delocalizing, de-training the actor might help the actor to orient oneself in the world.
Published: 2015

3. Regulation of Endurance Performance: New Frontiers

Author: Hollie S. Jones, Dominic Micklewright, Florentina J. Hettinga, Andrew Renfree, Benjamin Pageaux, Alexis R. Mauger, Jo Corbett, School of Sport and Exercise Sciences [University of Kent, Canterbury], University of Kent [Canterbury], School of Sport, Rehabilitation and Exercise Science [University of Essex, Colchester], University of Essex, Colchester, Institute of Sport and Exercise Science [University of Worcester], University of Worcester, Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] ( CAPS ), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), School of Psychology [University of Central Lancashire, Preston], University of Central Lancashire [Preston] ( UCLAN ), Department of Sport and Exercise Science [University of Portsmouth], University of Portsmouth, and université de Bourgogne, CAPS
Subjects: Reductionism, training, [SDV.MHEP.PHY] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], [ SDV.MHEP.PHY ] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Brain, Cycling, Task (project management), Variety (cybernetics), Running, Keywords: pacing, [ SDV.NEU ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Isolation (psychology), Muscle, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], triathlon, Psychology, Exercise, ComputingMilieux_MISCELLANEOUS, performance, Fatigue, Cognitive psychology
Abstract: Successful endurance performance requires the integration of multiple physiological and psychological systems, working together to regulate exercise intensity in a way that will reduce time taken or increase work done. The systems that ultimately limit performance of the task are hotly contested, and may depend on a variety of factors including the type of task, the environment, external influences, training status of the individual and a host of psychological constructs. These factors can be studied in isolation, or inclusively as a whole-body or integrative system. A reductionist approach has traditionally been favoured, leading to a greater understanding and emphasis on muscle and cardiovascular physiology, but the role of the brain and how this integrates multiple systems is gaining momentum. However, these differing approaches may have led to false dichotomy, and now with better understanding of both fields, there is a need to bring these perspectives together.
Published: 2017

4. 'Cocktail'-type catalysis on bimetallic systems for cinnamaldehyde selective hydrogenation: Role of isolated single atoms, nanoparticles and single atom alloys

Author: Audevard, Jérémy, Navarro-Ruiz, Javier, Bernardin, Vincent, Philippe, Régis, Corrias, Anna, Tison, Yann, Favre-Réguillon, Alain, Del rosal, Iker, Gerber, I.C., Serp, P., Laboratoire de chimie de coordination (LCC), Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de physique et chimie des nano-objets (LPCNO), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut de Chimie de Toulouse (ICT), Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Fédération de recherche « Matière et interactions » (FeRMI), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Catalyse, Polymérisation, Procédés et Matériaux (CP2M), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-École Supérieure de Chimie Physique Électronique de Lyon (CPE)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), University of Kent [Canterbury], Institut des sciences analytiques et de physico-chimie pour l'environnement et les materiaux (IPREM), Université de Pau et des Pays de l'Adour (UPPA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), and ANR-19-CE07-0030,COMET,Catalyse Coopérative Entre Atomes Et Nanoparticules Métalliques(2019)
Subjects: Hydrogen spillover, Nickel, [CHIM.CATA]Chemical Sciences/Catalysis, Ruthenium, Palladium, Selective hydrogenation, Single atoms
Abstract: International audience; Reaching high selectivity at high conversion and high rate in the industrially important selective hydrogenation of α,β-unsaturated aldehydes is a challenging task. Among current approaches reported in the literature, high selectivity towards the unsaturated alcohol or saturated aldehyde is generally achieved at the expense of activity. The use of bimetallic systems can lead either to selectivity or to activity enhancement, but generally not to both. Herein, we show that, for cinnamaldehyde hydrogenation, combining Ni nanoparticles (NiNP) and Ru single atoms (RuSA) on CNTs allows improvement of the hydrocinnamaldehyde selectivity, while obtaining a remarkable activity. The STY of RuSA-NiNP/CNT is approximately 60 times higher than that of the RuSA/CNT and 10 times higher than that of the NiNP/CNT. Importantly, the resulting catalyst shows 94% selectivity at 99% conversion and a good stability in flow. Insights into the cooperative “cocktail”-type catalysis between NiNP and RuSA were revealed from density functional theory calculations.
Published: 2023

5. Regulation of Endurance Performance: New Frontiers

Author: Benjamin Pageaux, Alexis R. Mauger, Andrew Renfree, Hollie S. Jones, Jo Corbett, Dominic Micklewright, Florentina J. Hettinga, School of Sport, Rehabilitation and Exercise Science [University of Essex, Colchester], University of Essex, Colchester, Institute of Sport and Exercise Science [University of Worcester], University of Worcester, Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] ( CAPS ), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), School of Psychology [University of Central Lancashire, Preston], University of Central Lancashire [Preston] ( UCLAN ), Department of Sport and Exercise Science [University of Portsmouth], University of Portsmouth, School of Sport and Exercise Sciences [University of Kent, Canterbury], and University of Kent [Canterbury]
Subjects: Operations research, Physiology, brain, B120, lcsh:Physiology, Task (project management), 03 medical and health sciences, recovery, 0302 clinical medicine, Physiology (medical), sport performance, 030212 general & internal medicine, ComputingMilieux_MISCELLANEOUS, endurance, Reductionism, pacing, training, lcsh:QP1-981, exercise, 030229 sport sciences, decision-making, C600, Variety (cybernetics), C813, Editorial, [ SDV.NEU ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Isolation (psychology), fatigue, Psychology, Sports and Exercise Sciences, Cognitive psychology
Abstract: Successful endurance performance requires the integration of multiple physiological and psychological systems, working together to regulate exercise intensity in a way that will reduce time taken or increase work done. The systems that ultimately limit performance of the task are hotly contested, and may depend on a variety of factors including the type of task, the environment, external influences, training status of the individual and a host of psychological constructs. These factors can be studied in isolation, or inclusively as a whole-body or integrative system. A reductionist approach has traditionally been favored, leading to a greater understanding and emphasis on muscle and cardiovascular physiology, but the role of the brain and how this integrates multiple systems is gaining momentum. However, these differing approaches may have led to false dichotomy, and now with better understanding of both fields, there is a need to bring these perspectives together.
Published: 2017

6. Energy Transfer and Restructuring in Amorphous Solid Water upon Consecutive Irradiation

Author: Herma M. Cuppen, Jennifer A. Noble, Stephane Coussan, Britta Redlich, Sergio Ioppolo, Simulation of Biomolecular Systems (HIMS, FNWI), Radboud University [Nijmegen], Physique des interactions ioniques et moléculaires (PIIM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), University of Kent [Canterbury], and Aarhus University [Aarhus]
Subjects: Earth and Planetary Astrophysics (astro-ph.EP), Chemical Physics (physics.chem-ph), Astrophysics - Solar and Stellar Astrophysics, Astrophysics of Galaxies (astro-ph.GA), Physics - Chemical Physics, FOS: Physical sciences, [PHYS.PHYS.PHYS-CHEM-PH]Physics [physics]/Physics [physics]/Chemical Physics [physics.chem-ph], FELIX Infrared and Terahertz Spectroscopy, Physical and Theoretical Chemistry, Theoretical Chemistry, Astrophysics - Astrophysics of Galaxies, Solar and Stellar Astrophysics (astro-ph.SR), Astrophysics - Earth and Planetary Astrophysics
Abstract: Interstellar and cometary ices play an important role in the formation of planetary systems around young stars. Their main constituent is amorphous solid water (ASW). Although ASW is widely studied, vibrational energy dissipation and structural changes due to vibrational excitation are less well understood. The hydrogen-bonding network is likely a crucial component in this. Here we present experimental results on hydrogen-bonding changes in ASW induced by the intense, nearly monochromatic mid-IR free-electron laser (FEL) radiation of the FELIX-2 beamline at the HFML-FELIX facility at the Radboud University in Nijmegen, the Netherlands. Structural changes in ASW are monitored by reflection-absorption infrared spectroscopy and depend on the irradiation history of the ice. The experiments show that FEL irradiation can induce changes in the local neighborhood of the excited molecules due to energy transfer. Molecular Dynamics simulations confirm this picture: vibrationally excited molecules can reorient for a more optimal tetrahedral surrounding without breaking existing hydrogen bonds. The vibrational energy can transfer through the hydrogen-bonding network to water molecules that have the same vibrational frequency. We hence expect a reduced energy dissipation in amorphous material with respect to crystalline material due to the inhomogeneity in vibrational frequencies as well as the presence of specific hydrogen-bonding defect sites which can also hamper the energy transfer., 34 page, 9 figures
Published: 2022

7. Morphological integration and shape covariation betweenthe trapezium and first metacarpal among extant hominids

Author: Bardo, Ameline, Dunmore, Christopher, Cornette, Raphael, Kivell, Tracy, Histoire naturelle de l'Homme préhistorique (HNHP), Muséum national d'Histoire naturelle (MNHN)-Université de Perpignan Via Domitia (UPVD)-Centre National de la Recherche Scientifique (CNRS), School of Anthropology and Conservation [University of Kent], University of Kent [Canterbury], Institut de Systématique, Evolution, Biodiversité (ISYEB ), Muséum national d'Histoire naturelle (MNHN)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA), Department of Human Origins, Max Planck Institute for Evolutionary Anthropology, Fyssen Foundation Research Fellowship (AB), and European Project: 336301,EC:FP7:ERC,ERC-2013-StG,GRASP(2014)
Subjects: [SDV]Life Sciences [q-bio], [SHS.ANTHRO-BIO]Humanities and Social Sciences/Biological anthropology
Abstract: International audience; ObjectivesThe shape of the trapezium and first metacarpal (Mc1) markedly influence thumb mobility, strength, and the manual abilities of extant hominids. Previous research has typically focused solely on trapezium-Mc1 joint shape. Here we investigate how morphological integration and shape covariation between the entire trapezium (articular and non-articular surfaces) and the entire Mc1 reflect known differences in thumb use in extant hominids.Materials and MethodsWe analyzed shape covariation in associated trapezia and Mc1s across a large, diverse sample of Homo sapiens (n = 40 individuals) and other extant hominids (Pan troglodytes, n = 16; Pan paniscus, n = 13; Gorilla gorilla gorilla, n = 27; Gorilla beringei, n = 6; Pongo pygmaeus, n = 14; Pongo abelii, n = 9) using a 3D geometric morphometric approach. We tested for interspecific significant differences in degree of morphological integration and patterns of shape covariation between the entire trapezium and Mc1, as well as within the trapezium-Mc1 joint specifically.ResultsSignificant morphological integration was only found in the trapezium-Mc1 joint of H. sapiens and G. g. gorilla. Each genus showed a specific pattern of shape covariation between the entire trapezium and Mc1 that was consistent with different intercarpal and carpometacarpal joint postures.DiscussionOur results are consistent with known differences in habitual thumb use, including a more abducted thumb during forceful precision grips in H. sapiens and a more adducted thumb in other hominids used for diverse grips. These results will help to infer thumb use in fossil hominins.
Published: 2023

8. From fossils to mind

Author: de Sousa, A., Beaudet, A., Calvey, T., Bardo, A., Benoit, J., Charvet, C., Dehay, C., Gómez-Robles, A., Gunz, P., https://orcid.org/0000-0002-2350-4450, Heuer, K., van den Heuvel, M., Hurst, S., Lauters, P., Reed, D., Salagnon, M., Sherwood, C., Ströckens, F., Tawane, M., Todorov, O., Toro, R., Wei, Y., de Sousa, Alexandra A [0000-0003-2379-3894], Beaudet, Amélie [0000-0002-9363-5966], Calvey, Tanya [0000-0002-7540-2130], Bardo, Ameline [0000-0003-1840-6423], Gómez-Robles, Aida [0000-0002-8719-2660], Gunz, Philipp [0000-0002-2350-4450], Heuer, Katja [0000-0002-7237-0196], van den Heuvel, Martijn P [0000-0003-1570-1195], Hurst, Shawn [0000-0002-1458-759X], Lauters, Pascaline [0000-0003-3664-3182], Sherwood, Chet C [0000-0001-6711-449X], Todorov, Orlin S [0000-0002-0295-7557], Apollo - University of Cambridge Repository, Bath Spa University, Laboratoire de paléontologie, évolution, paléoécosystèmes, paléoprimatologie (PALEVOPRIM ), Université de Poitiers-Centre National de la Recherche Scientifique (CNRS), University of Cambridge [UK] (CAM), University of Cape Town, Histoire naturelle de l'Homme préhistorique (HNHP), Muséum national d'Histoire naturelle (MNHN)-Université de Perpignan Via Domitia (UPVD)-Centre National de la Recherche Scientifique (CNRS), University of Kent [Canterbury], University of the Witwatersrand [Johannesburg] (WITS), Auburn University (AU), Institut cellule souche et cerveau / Stem Cell and Brain Research Institute (SBRI), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University College of London [London] (UCL), Max Planck Institute for Evolutionary Anthropology [Leipzig], Max-Planck-Gesellschaft, Neuroanatomie Appliquée et Théorique / Applied and Theoretical Neuroanatomy (NAAT), Institut Pasteur [Paris] (IP)-Université Paris Cité (UPCité), Vrije Universiteit Amsterdam [Amsterdam] (VU), Indiana University - Purdue University Indianapolis (IUPUI), Indiana University System, Institut Royal des Sciences Naturelles de Belgique (IRSNB), University of Texas at Austin [Austin], Institut des Maladies Neurodégénératives [Bordeaux] (IMN), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie (PACEA), The George Washington University (GW), Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf], Ditsong National Museum of Natural History [Pretoria, South Africa] (DNMNH), Macquarie University [Sydney], Beijing University of Posts and Telecommunications (BUPT), A.Ba. was funded by the Agence Nationale de la Recherche (grant number: ANR-20-CE27-0009-01). A.Be. was funded by the National Research Foundation of South Africa (Research Development Grants for Y-Rated Researchers (grant number 129336) and the South Africa/France (PROTEA) Joint Research Programme (grant number 129923). C.C.S. was funded by NSF (EF-2021785, DRL-2219759) and NIH (NS092988, AG067419, HG011641). C.J.C. was funded by NIGMS COBRE (grant number 5P20GM103653). J.B. was funded by the NRF African Origins Platform. K.H. and R.T. were supported by the French Agence Nationale de la Recherche, projects NeuroWebLab (ANR-19-DATA-0025) and DMOBE (ANR-21-CE45-0016). K.H. has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No101033485 (Individual Fellowship). O.S.T was funded by a Discovery Project Award (project number: DP210101324) funded by the Australian Government. P.G. was funded by the Max Planck Society (grant number M.IF.A.XXXX8103)., ANR-20-CE27-0009,PaleoBRAIN,Ressusciter le cerveau d'Homo erectus et des Néandertaliens(2020), ANR-19-DATA-0025,NeuroWebLab,Un laboratoire de neuroscience collectif: Au delà de FAIR(2019), and ANR-21-CE45-0016,DMOBE,Méchanique dévelopemental de l'évolution du cerveau(2021)
Subjects: [SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, Archaeology, Fossils, Brain, Artifacts, Phylogeny, [SHS]Humanities and Social Sciences
Abstract: International audience; Fossil endocasts record features of brains from the past: size, shape, vasculature, and gyrification. These data, alongside experimental and comparative evidence, are needed to resolve questions about brain energetics, cognitive specializations, and developmental plasticity. Through the application of interdisciplinary techniques to the fossil record, paleoneurology has been leading major innovations. Neuroimaging is shedding light on fossil brain organization and behaviors. Inferences about the development and physiology of the brains of extinct species can be experimentally investigated through brain organoids and transgenic models based on ancient DNA. Phylogenetic comparative methods integrate data across species and associate genotypes to phenotypes, and brains to behaviors. Meanwhile, fossil and archeological discoveries continuously contribute new knowledge. Through cooperation, the scientific community can accelerate knowledge acquisition. Sharing digitized museum collections improves the availability of rare fossils and artifacts. Comparative neuroanatomical data are available through online databases, along with tools for their measurement and analysis. In the context of these advances, the paleoneurological record provides ample opportunity for future research. Biomedical and ecological sciences can benefit from paleoneurology’s approach to understanding the mind as well as its novel research pipelines that establish connections between neuroanatomy, genes and behavior.
Published: 2023

9. Follow-up investigation into Cryptosporidium prevalence and transmission in Western European dairy farms

Author: Sumaiya Hoque, Pedro Pinto, Cláudia A. Ribeiro, Evi Canniere, Yvonne Daandels, Martine Dellevoet, Anne Bourgeois, Ourida Hammouma, Paul Hunter, Eleni Gentekaki, Martin Kváč, Jérôme Follet, Anastasios D. Tsaousis, University of Kent [Canterbury], Faculdade de Engenharia da Universidade do Porto (FEUP), Universidade do Porto = University of Porto, University of Algarve [Portugal], Inagro, Biological Data Analysis ['s-Hertogenbosch, The Netherlands], PamGene International B.V. ['s-Hertogenbosch, The Netherlands], Affectations Mineralisantes du Systeme Cardiovasculaire : Calcifications Arterielles et Valvulaires Aortiques, Université de Picardie Jules Verne (UPJV)-Institut National de la Santé et de la Recherche Médicale (INSERM), Transfrontalière BioEcoAgro - UMR 1158 (BioEcoAgro), Université d'Artois (UA)-Université de Liège-Université de Picardie Jules Verne (UPJV)-Université du Littoral Côte d'Opale (ULCO)-Université de Lille-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), JUNIA (JUNIA), Université catholique de Lille (UCL), University of Lille, Université libre de Bruxelles (ULB), University of East Anglia [Norwich] (UEA), Faculty of Computer Science, Dalhousie University [Halifax], Mae Fah Luang University [Thaïlande] (MFU), Institute of Parasitology [České Budějovice] (BIOLOGY CENTRE CAS), Biology Centre of the Czech Academy of Sciences (BIOLOGY CENTRE CAS), Czech Academy of Sciences [Prague] (CAS)-Czech Academy of Sciences [Prague] (CAS), University of South Bohemia, Faculty of Agriculture, Studentska 13, 370 05 Ceske Budejovice, Bio-Micro-Electro-Mechanical Systems - IEMN (BIOMEMS - IEMN), Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), and no information
Subjects: [PHYS]Physics [physics], [SPI]Engineering Sciences [physics], General Veterinary, Belgium, Epidemiology, Dairy cows, Prevalence, Cryptosporidium, Parasitology, The Netherlands, General Medicine, France, Diarrhoea
Abstract: International audience; AbstractCryptosporidium parvum is an enteric parasite and a major contributor to acute enteritis in calves worldwide, causing an important economic burden for farmers. This parasite poses a major public health threat through transmission between livestock and humans. Our previous pilot study in Western Europe revealed a high prevalence of Cryptosporidium in calves of dairy farms. In the sequel study herein, 936 faecal samples were collected from the same 51 dairy farms across Belgium, France, and the Netherlands. Following DNA extraction, Cryptosporidium screening was carried out using nested-PCR amplification targeting the SSU rRNA gene. All positive samples were sequenced, and phylogenetic analyses were used to identify the Cryptosporidium spp. present. The 60 kDa glycoprotein (gp60) gene was also sequenced to determine the C. parvum subtypes present. Prevalence of Cryptosporidium ranged from 23.3% to 25%, across the three countries surveyed. The parasite was found in most of the farms sampled, with 90.2% testing positive. Cryptosporidium parvum, C. bovis, C. ryanae and C. andersoni were all identified, with the former being the most predominant, representing 71.4% of all infections. Cryptosporidium parvum was associated with pre-weaned calves, while other species were associated with older animals. Subtyping of gp60 gene revealed nine subtypes, eight of which have previously been reported to cause clinical disease in humans. Similarly to the first study, vertical transmission was not a major contributor to Cryptosporidium spread. Our study highlights the need for further investigation into cryptosporidiosis transmission, and future studies will require a One Health approach to reduce the impact of this disease.
Published: 2023

10. Stochastic local search and parameters recommendation: a case study on flowshop problems

Author: Lucas M. Pavelski, Marie-Eléonore Kessaci, Myriam Regattieri Delgado, Alex A. Freitas, Federal University of Technology - Paraná (UTFPR), Operational Research, Knowledge And Data (ORKAD), Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), School of Computing [Kent], and University of Kent [Canterbury]
Subjects: Mathematical optimization, Computer science, business.industry, Management of Technology and Innovation, Strategy and Management, Local search (optimization), [INFO.INFO-RO]Computer Science [cs]/Operations Research [cs.RO], Management Science and Operations Research, Business and International Management, [INFO.INFO-DM]Computer Science [cs]/Discrete Mathematics [cs.DM], business, Computer Science Applications
Abstract: International audience
Published: 2023

11. N-graphene synthesized in astrochemical ices

Author: B. Sivaraman, K. K. Rahul, M. Ambresh, D. Sahu, J. K. Meka, S.-L. Chou, Y.-J. Wu, D. Gupta, A. Das, J.-I. Lo, B.-M. Cheng, B. N. Rajasekhar, Anil Bhardwaj, H. Hill, P. Janardhan, N. J. Mason, Physical Research Laboratory [Ahmedabad] (PRL), Indian Space Research Organisation (ISRO), Indian Institute of Science [Bangalore] (IISc Bangalore), Academia Sinica, National Synchrotron Radiation Research Center (NSRRC), Institut de Physique de Rennes (IPR), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS), Universität zu Köln = University of Cologne, Bhabha Atomic Research Centre (BARC), Government of India, Department of Atomic Energy, International Space University (ISU), University of Kent [Canterbury], Horizon 2020 Framework Programme, H2020: 654208, 871149, Indian Space Research Organisation, इसरो, National Synchrotron Radiation Research Center, NSRRC: IFA-11CH-11, Physical Research Laboratory, PRL, European Project: 654208,H2020,H2020-INFRAIA-2014-2015,EPN2020-RI(2015), and European Project: 8711495(1988)
Subjects: Synthesised, Aromatic compounds, Nitrogen, Vacuum ultraviolets, Graphene sheets, Laboratory experiments, Physics::Optics, FOS: Physical sciences, High resolution transmission electron microscopy, Energy dispersive spectroscopy, Physics::Atomic and Molecular Clusters, Semiconductor quantum dots, Physics::Chemical Physics, Condition, Instrumentation and Methods for Astrophysics (astro-ph.IM), [PHYS]Physics [physics], Side-chains, Carbon structures, Ice, Benzonitriles, Interstellar medias, Atomic and Molecular Physics, and Optics, Complex molecules, Irradiation, Graphene, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: Icy mantles of benzonitrile, an aromatic with a cyanide side chain that has recently been detected in the interstellar medium, were subjected to vacuum ultraviolet photon irradiation and found to form a residue. The residue was removed from the substrate and placed on a Quantifoil grid for electron microscopy analysis. Transmission electron microscopy showed Quantum Dot (QD) and Nitrogen-doped Graphene (N-Graphene) sheets. Diffraction and Energy Dispersive X-ray Spectroscopy revealed the crystalline nature and carbon-nitrogen composition, of the observed graphene sheet. This is the first result showing QD and N-Graphene synthesis in ice irradiation at interstellar temperatures., Comment: 10 pages, 3 figures
Published: 2023

12. Molecular-rotation-induced splitting of the binary ridge in the velocity map of sub-eV H+ ions ejected from H2 molecules by ion impact

Author: Juhász, Z., Kovács, S, Vizcaïno, V., Herczku, P., Demes, Sándor, Rácz, R., Sulik, B., Biri, S., Sens, N., Mifsud, D., Chesnel, J.-Y., Institute for Nuclear Research [Budapest] (ATOMKI), Hungarian Academy of Sciences (MTA), Centre de recherche sur les Ions, les MAtériaux et la Photonique (CIMAP - UMR 6252), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche sur les Matériaux Avancés (IRMA), Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Rouen Normandie (UNIROUEN), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Atomes, Molécules et Agrégats (AMA), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Université de Caen Normandie (UNICAEN), Centre for Astrophysics and Planetary Science [Canterbury] (CAPS), University of Kent [Canterbury], National Research, Development and Innovation Office, K18 funding scheme, Project No. K128621, CNRS International Emerging Action (IEA-PICS-CNRS No. 7739 & Project NKM-115/2017), and COST Action CA18212 – Molecular Dynamics in the GAS phase (MD-GAS)
Subjects: [PHYS]Physics [physics], [PHYS.PHYS.PHYS-AO-PH]Physics [physics]/Physics [physics]/Atmospheric and Oceanic Physics [physics.ao-ph], molecular processes, [PHYS.PHYS.PHYS-ATM-PH]Physics [physics]/Physics [physics]/Atomic and Molecular Clusters [physics.atm-clus], charge-transfer, Molecular reaction, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Ion-molecule collision, Rotational Dynamics
Abstract: International audience; In studies of ion-induced molecular fragmentation, the challenging measurement of the velocity distribution of fragments emitted below 1-eV kinetic energy is rarely achieved, although most fragments have an energy below this value. Here, we study H$^+$ fragment emission in collisions of 10-keV O$^+$ ions with H$_2$ molecules using a field-free time-of-flight technique developed specifically to detect sub-eV fragments. We find that, in the velocity map, the binary ridge due to direct H$^+$ knockout is split into two parts arising from the rotational motion of the H$_2$ molecule, and that this split scales with rotational velocity. The velocity distribution of the nuclei in the original molecule is determined and the thermally populated J = 1 rotational level is found to be the dominant contributor, although asymmetry in the split indicates projectile-induced rotational transitions between M sublevels. These rotation effects influence fragment emission probabilities, thus carrying important consequences for the radiation-induced hydrogen loss and H$_2$ dissociation in the atmospheres or exospheres of planets and moons.
Published: 2023

13. Adjustment of the Single Atom/Nanoparticle Ratio in Pd/CNT Catalysts for Phenylacetylene Selective Hydrogenation

Author: Jérémy Audevard, Javier Navarro‐Ruiz, Vincent Bernardin, Yann Tison, Anna Corrias, Iker Del Rosal, Alain Favre‐Réguillon, Régis Philippe, Iann C. Gerber, Philippe Serp, Laboratoire de chimie de coordination (LCC), Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de physique et chimie des nano-objets (LPCNO), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut de Chimie de Toulouse (ICT), Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Fédération de recherche « Matière et interactions » (FeRMI), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Catalyse, Polymérisation, Procédés et Matériaux (CP2M), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-École Supérieure de Chimie Physique Électronique de Lyon (CPE)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut des sciences analytiques et de physico-chimie pour l'environnement et les materiaux (IPREM), Université de Pau et des Pays de l'Adour (UPPA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), University of Kent [Canterbury], Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), and ANR-19-CE07-0030,COMET,Catalyse Coopérative Entre Atomes Et Nanoparticules Métalliques(2019)
Subjects: Inorganic Chemistry, Organic Chemistry, Nanoparticles, [CHIM]Chemical Sciences, Hydrogenation, [CHIM.CATA]Chemical Sciences/Catalysis, Physical and Theoretical Chemistry, Catalysis, Palladium, Carbon, Hydrogen
Abstract: International audience; Pd/C catalysts are widely used for hydrogenation reactions in the chemical industry. One of the reasons for their high activity is the ability of Pd nanoparticles (PdNP) to dissociate H2 and promote H-spillover. Nevertheless, for selective hydrogenation unpromoted Pd/C catalysts show disappointing results. The use of supported Pd single atom (PdSA) catalysts permits to achieve high selectivity. However, PdSA show low activity because they have difficulty in activating H2. A cooperative catalysis between PdNP and PdSA operates for the hydrogenation of alkenes thanks to the H-spillover, which makes it possible to obtain active isolated PdSA−H species. Here, we present experimental and computational results obtained for phenylacetylene hydrogenation on Pd/CNT catalysts showing different PdSA/PdNP ratios. Tuning this ratio allows doubling the activity while reaching high selectivity to styrene at high conversion. DFT calculations suggest that the first coordination sphere of PdSA has a pronounced effect on their reactivity.
Published: 2023

14. Infrared free-electron laser irradiation of carbon dioxide ice

Author: Sergio Ioppolo, Jennifer A. Noble, Alejandra Traspas Muiña, Herma M. Cuppen, Stéphane Coussan, Britta Redlich, Queen Mary University of London (QMUL), Physique des interactions ioniques et moléculaires (PIIM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), University of Kent [Canterbury], Institute for Molecules and Materials [Nijmegen], and Radboud University [Nijmegen]
Subjects: Methods: laboratory, ISM [Infrared], FOS: Physical sciences, FELIX Infrared and Terahertz Spectroscopy, Astrophysics - Astrophysics of Galaxies, Atomic and Molecular Physics, and Optics, ISM: molecules, spectroscopic [Techniques], [CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry, Techniques free-electron laser, Infrared ISM, Astrophysics of Galaxies (astro-ph.GA), free-electron laser [Techniques], Astrophysics::Earth and Planetary Astrophysics, Physical and Theoretical Chemistry, Theoretical Chemistry, [SDU.OTHER]Sciences of the Universe [physics]/Other, Spectroscopy, Techniques spectroscopic, molecules [ISM], Physics::Atmospheric and Oceanic Physics, Astrochemistry, laboratory [Methods]
Abstract: Interstellar ice grains are believed to play a key role in the formation of many of the simple and complex organic species detected in space. However, many fundamental questions on the physicochemical processes linked to the formation and survival of species in ice grains remain unanswered. Field work at large-scale facilities such as free-electron lasers (FELs) can aid the investigation of the composition and morphology of ice grains by providing novel tools to the laboratory astrophysics community. We combined the high tunability, wide infrared spectral range and intensity of the FEL beam line FELIX-2 at the HFML-FELIX Laboratory in the Netherlands with the characteristics of the ultrahigh vacuum LISA end station to perform wavelength-dependent mid-IR irradiation experiments of space-relevant pure carbon dioxide (CO2) ice at 20 K. We used the intense monochromatic radiation of FELIX to inject vibrational energy at selected frequencies into the CO2 ice to study ice restructuring effects in situ by Fourier Transform Reflection-Absorption Infrared (FT-RAIR) spectroscopy. This work improves our understanding of how vibrational energy introduced by external triggers such as photons, electrons, cosmic rays, and thermal heating coming from a nascent protostar or field stars is dissipated in an interstellar icy dust grain in space. Moreover, it adds to the current literature debate concerning the amorphous and polycrystalline structure of CO2 ice observed upon deposition at low temperatures, showing that, under our experimental conditions, CO2 ice presents amorphous characteristics when deposited at 20 K and is unambiguously crystalline if deposited at 75 K., Comment: Published in the 'Journal of Molecular Spectroscopy'. Includes 11 pages, 7 figures
Published: 2022

15. Predicting attitudinal and behavioral responses to COVID-19 pandemic using machine learning

Author: Tomislav Pavlović, Flavio Azevedo, Koustav De, Julián C Riaño-Moreno, Marina Maglić, Theofilos Gkinopoulos, Patricio Andreas Donnelly-Kehoe, César Payán-Gómez, Guanxiong Huang, Jaroslaw Kantorowicz, Michèle D Birtel, Philipp Schönegger, Valerio Capraro, Hernando Santamaría-García, Meltem Yucel, Agustin Ibanez, Steve Rathje, Erik Wetter, Dragan Stanojević, Jan-Willem van Prooijen, Eugenia Hesse, Christian T Elbaek, Renata Franc, Zoran Pavlović, Panagiotis Mitkidis, Aleksandra Cichocka, Michele Gelfand, Mark Alfano, Robert M Ross, Hallgeir Sjåstad, John B Nezlek, Aleksandra Cislak, Patricia Lockwood, Koen Abts, Elena Agadullina, David M Amodio, Matthew A J Apps, John Jamir Benzon Aruta, Sahba Besharati, Alexander Bor, Becky Choma, William Cunningham, Waqas Ejaz, Harry Farmer, Andrej Findor, Biljana Gjoneska, Estrella Gualda, Toan L D Huynh, Mostak Ahamed Imran, Jacob Israelashvili, Elena Kantorowicz-Reznichenko, André Krouwel, Yordan Kutiyski, Michael Laakasuo, Claus Lamm, Jonathan Levy, Caroline Leygue, Ming-Jen Lin, Mohammad Sabbir Mansoor, Antoine Marie, Lewend Mayiwar, Honorata Mazepus, Cillian McHugh, Andreas Olsson, Tobias Otterbring, Dominic Packer, Jussi Palomäki, Anat Perry, Michael Bang Petersen, Arathy Puthillam, Tobias Rothmund, Petra C Schmid, David Stadelmann, Augustin Stoica, Drozdstoy Stoyanov, Kristina Stoyanova, Shruti Tewari, Bojan Todosijević, Benno Torgler, Manos Tsakiris, Hans H Tung, Radu Gabriel Umbreș, Edmunds Vanags, Madalina Vlasceanu, Andrew J Vonasch, Yucheng Zhang, Mohcine Abad, Eli Adler, Hamza Alaoui Mdarhri, Benedict Antazo, F Ceren Ay, Mouhamadou El Hady Ba, Sergio Barbosa, Brock Bastian, Anton Berg, Michał Białek, Ennio Bilancini, Natalia Bogatyreva, Leonardo Boncinelli, Jonathan E Booth, Sylvie Borau, Ondrej Buchel, Chrissie Ferreira de Carvalho, Tatiana Celadin, Chiara Cerami, Hom Nath Chalise, Xiaojun Cheng, Luca Cian, Kate Cockcroft, Jane Conway, Mateo A Córdoba-Delgado, Chiara Crespi, Marie Crouzevialle, Jo Cutler, Marzena Cypryańska, Justyna Dabrowska, Victoria H Davis, John Paul Minda, Pamala N Dayley, Sylvain Delouvée, Ognjan Denkovski, Guillaume Dezecache, Nathan A Dhaliwal, Alelie Diato, Roberto Di Paolo, Uwe Dulleck, Jānis Ekmanis, Tom W Etienne, Hapsa Hossain Farhana, Fahima Farkhari, Kristijan Fidanovski, Terry Flew, Shona Fraser, Raymond Boadi Frempong, Jonathan Fugelsang, Jessica Gale, E Begoña García-Navarro, Prasad Garladinne, Kurt Gray, Siobhán M Griffin, Bjarki Gronfeldt, June Gruber, Eran Halperin, Volo Herzon, Matej Hruška, Matthias F C Hudecek, Ozan Isler, Simon Jangard, Frederik Jørgensen, Oleksandra Keudel, Lina Koppel, Mika Koverola, Anton Kunnari, Josh Leota, Eva Lermer, Chunyun Li, Chiara Longoni, Darragh McCashin, Igor Mikloušić, Juliana Molina-Paredes, César Monroy-Fonseca, Elena Morales-Marente, David Moreau, Rafał Muda, Annalisa Myer, Kyle Nash, Jonas P Nitschke, Matthew S Nurse, Victoria Oldemburgo de Mello, M Soledad Palacios-Galvez, Yafeng Pan, Zsófia Papp, Philip Pärnamets, Mariola Paruzel-Czachura, Silva Perander, Michael Pitman, Ali Raza, Gabriel Gaudencio Rêgo, Claire Robertson, Iván Rodríguez-Pascual, Teemu Saikkonen, Octavio Salvador-Ginez, Waldir M Sampaio, Gaia Chiara Santi, David Schultner, Enid Schutte, Andy Scott, Ahmed Skali, Anna Stefaniak, Anni Sternisko, Brent Strickland, Jeffrey P Thomas, Gustav Tinghög, Iris J Traast, Raffaele Tucciarelli, Michael Tyrala, Nick D Ungson, Mete Sefa Uysal, Dirk Van Rooy, Daniel Västfjäll, Joana B Vieira, Christian von Sikorski, Alexander C Walker, Jennifer Watermeyer, Robin Willardt, Michael J A Wohl, Adrian Dominik Wójcik, Kaidi Wu, Yuki Yamada, Onurcan Yilmaz, Kumar Yogeeswaran, Carolin-Theresa Ziemer, Rolf A Zwaan, Paulo Sergio Boggio, Ashley Whillans, Paul A M Van Lange, Rajib Prasad, Michal Onderco, Cathal O'Madagain, Tarik Nesh-Nash, Oscar Moreda Laguna, Emily Kubin, Mert Gümren, Ali Fenwick, Arhan S Ertan, Michael J Bernstein, Hanane Amara, Jay Joseph Van Bavel, Brain and Cognition, Public Administration, Pavlovic, Tomislav, Avezedo, Flávio, De, Koustav, Maglić, Marina, Donnelly-Kehoe, Patricio Andreas, Payán-Gómez, César, Van Bavel, Jay J., Schmid, Petra Claudia, Crouzevialle, Marie, Willardt, Robin, et al., Ivo Pilar Institute of Social Sciences, University of Cambridge [UK] (CAM), University of Kentucky (UK), Universidad El Bosque [Bogota], University of Crete [Heraklion] (UOC), Universidad del Rosario [Bogota], Universidad Nacional de Colombia [Bogotà] (UNAL), City University of Hong Kong [Hong Kong] (CUHK), Universiteit Leiden, University of Greenwich, University of St Andrews [Scotland], Middlesex University [London], Pontifical Xavierian University, Duke University [Durham], Universidad Adolfo Ibáñez [Santiago], University of California (UC), Trinity College Dublin, Stockholm School of Economics (SSE), University of Belgrade [Belgrade], Vrije Universiteit Amsterdam [Amsterdam] (VU), Universidad Mayor de San Andrés (UMSA), Aarhus University [Aarhus], University of Kent [Canterbury], Stanford University, Macquarie University, Norwegian School of Economics and Business Administration, SWPS University of Social Sciences and Humanities (SWPS), University of Birmingham [Birmingham], University of Oxford, Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Vysšaja škola èkonomiki = National Research University Higher School of Economics [Moscow] (HSE), University of Amsterdam [Amsterdam] (UvA), Sunway University [Malaysia], University of the Witwatersrand [Johannesburg] (WITS), University of Toronto, National University of Sciences and Technology [Islamabad] (NUST), Comenius University in Bratislava, Macedonian Academy of Sciences and Arts [Skopje, North Macedonia] (MASA), Universidad de Huelva, University of Southampton, BRAC University, The Hebrew University of Jerusalem (HUJ), Erasmus University Rotterdam, Kieskompas, Helsingin yliopisto = Helsingfors universitet = University of Helsinki, University of Vienna [Vienna], Reichman University [Herzliya], Aalto University, Universidad Nacional Autónoma de México = National Autonomous University of Mexico (UNAM), National Taiwan University [Taiwan] (NTU), HEMS School, BI Norwegian Business School [Oslo], University of Limerick (UL), Karolinska Institutet [Stockholm], University of Agder (UIA), Lehigh University [Bethlehem], Monk Prayogshala, Friedrich-Schiller-Universität = Friedrich Schiller University Jena [Jena, Germany], Eidgenössische Technische Hochschule Zürich - Swiss Federal Institute of Technology in Zürich (ETH Zurïch), University of Bayreuth, National School of Political and Administrative Studies (SNSPA), Plovdiv University 'Paisii Hilendarski', Indian Institute of Management Indore (IMM Indore), Institute of Social Sciences Belgrade, Queensland University of Technology [Brisbane] (QUT), Royal Holloway [University of London] (RHUL), University of London [London], National University of Political Studies and Public Administration, University of Latvia (LU), New York University [New York] (NYU), NYU System (NYU), University of Canterbury [Christchurch], Hebei University of Technology [Tianjin], Université Mohammed VI Polytechnique [Ben Guerir] (UM6P), AnsuR Technologies [Fornebu], Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD), Victoria University [Melbourne], University of Wrocław [Poland] (UWr), IMT Institute for Advanced Studies [Lucca], Université de Florence, Università degli Studi di Firenze = University of Florence (UniFI), London School of Economics and Political Science (LSE), TBS Education, Slovak Academy of Science [Bratislava] (SAS), Santa Catarina State University (UDESC), University of Bologna/Università di Bologna, Tribhuvan University, Shenzhen Univerisity [Shenzhen], University of Virginia, Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT), University of Western Ontario (UWO), Université de Rennes 2 (UR2), Laboratoire de Psychologie Sociale et Cognitive (LAPSCO), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), University of British Columbia (UBC), University of Queensland [Brisbane], Pennsylvania State University (Penn State), Penn State System, Westfälische Wilhelms-Universität Münster = University of Münster (WWU), The University of Sydney, University of Waterloo [Waterloo], University of North Carolina [Chapel Hill] (UNC), University of North Carolina System (UNC), University of Colorado [Boulder], University of Regensburg, Kyiv School of economic (KSE), Linköping University (LIU), Monash University [Clayton], Ansbach University of Applied Sciences, Ludwig Maximilian University [Munich] (LMU), Department of Management - London School of Economics and Political Science (LSE), Questrom School of Business, Boston University [Boston] (BU), Dublin City University [Dublin] (DCU), University of Auckland [Auckland], Maria Curie-Sklodowska University (UMCS), City University of New York [New York] (CUNY), University of Alberta, Australian National University (ANU), University of Silesia in Katowice, Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] (UCM), Zhejiang University, Mackenzie Presbyterian University [São Paulo] (UPM), NYU Department of Psychology [New-York University], NYU System (NYU)-NYU System (NYU), University of Turku, City College of New York [CUNY] (CCNY), University of Groningen [Groningen], Carleton University, Département d'Etudes Cognitives - ENS Paris (DEC), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Faculté de Gouvernance, Sciences Économiques et Sociales [UM6P] (FGSES), University College of London [London] (UCL), Susquehanna University, University of Antwerp (UA), University of Exeter, University of Koblenz-Landau, Nicolaus Copernicus University [Toruń], University of California [San Diego] (UC San Diego), Kyushu University, Kadir Has University (KHAS), Harvard Business School, Harvard University, Vidyasagar College For Women, Koç University, Hult International Business School, Boǧaziçi üniversitesi = Boğaziçi University [Istanbul], Penn State Abington, Pennsylvania Commonwealth System of Higher Education (PCSHE)-Penn State System, Communication Science, Network Institute, Communication Choices, Content and Consequences (CCCC), Social Psychology, IBBA, A-LAB, University of St Andrews. Philosophy, University of St Andrews. School of Psychology and Neuroscience, Pavlović, Tomislav [0000-0002-4470-3715], Azevedo, Flavio [0000-0001-9000-8513], De, Koustav [0000-0001-9562-0672], Riaño-Moreno, Julián C [0000-0003-4182-0550], Maglić, Marina [0000-0002-6851-4601], Gkinopoulos, Theofilos [0000-0003-1070-6245], Donnelly-Kehoe, Patricio Andreas [0000-0002-3738-9537], Payán-Gómez, César [0000-0002-0633-1332], Huang, Guanxiong [0000-0002-8588-1454], Kantorowicz, Jaroslaw [0000-0002-1186-5427], Birtel, Michèle D [0000-0002-2383-9197], Schönegger, Philipp [0000-0001-9930-487X], Capraro, Valerio [0000-0002-0579-0166], Santamaría-García, Hernando [0000-0001-9422-3579], Yucel, Meltem [0000-0002-7274-5971], Ibanez, Agustin [0000-0001-6758-5101], Rathje, Steve [0000-0001-6727-571X], Wetter, Erik [0000-0002-5821-6651], Stanojević, Dragan [0000-0002-3667-2461], van Prooijen, Jan-Willem [0000-0001-6236-0819], Hesse, Eugenia [0000-0002-9077-9833], Elbaek, Christian T [0000-0002-7039-4565], Franc, Renata [0000-0002-1909-2393], Pavlović, Zoran [0000-0002-9231-5100], Mitkidis, Panagiotis [0000-0002-9495-7369], Cichocka, Aleksandra [0000-0003-1703-1586], Alfano, Mark [0000-0001-5879-8033], Ross, Robert M [0000-0001-8711-1675], Sjåstad, Hallgeir [0000-0002-8730-1038], Nezlek, John B [0000-0003-4963-3637], Cislak, Aleksandra [0000-0002-9880-6947], Lockwood, Patricia [0000-0001-7195-9559], Abts, Koen [0000-0001-8546-8347], Agadullina, Elena [0000-0002-1505-1412], Amodio, David M [0000-0001-7746-0150], Apps, Matthew AJ [0000-0001-5793-2202], Aruta, John Jamir Benzon [0000-0003-4155-1063], Besharati, Sahba [0000-0003-2836-7982], Bor, Alexander [0000-0002-2624-9221], Choma, Becky [0000-0002-8286-8983], Ejaz, Waqas [0000-0002-2492-4115], Farmer, Harry [0000-0002-3684-0605], Findor, Andrej [0000-0002-5896-6989], Gjoneska, Biljana [0000-0003-1200-6672], Gualda, Estrella [0000-0003-0220-2135], Huynh, Toan LD [0000-0002-6653-7447], Imran, Mostak Ahamed [0000-0002-5101-3149], Israelashvili, Jacob [0000-0003-1289-223X], Kantorowicz-Reznichenko, Elena [0000-0001-8128-7290], Krouwel, André [0000-0003-0952-6028], Kutiyski, Yordan [0000-0003-0889-4232], Laakasuo, Michael [0000-0003-2826-6073], Lamm, Claus [0000-0002-5422-0653], Levy, Jonathan [0000-0003-1007-2393], Leygue, Caroline [0000-0002-0355-1030], Lin, Ming-Jen [0000-0002-7174-2226], Mansoor, Mohammad Sabbir [0000-0002-6541-3506], Marie, Antoine [0000-0002-7958-0153], Mayiwar, Lewend [0000-0003-1404-4779], Mazepus, Honorata [0000-0002-5005-9399], McHugh, Cillian [0000-0002-9701-3232], Olsson, Andreas [0000-0001-5272-7744], Otterbring, Tobias [0000-0002-0283-8777], Packer, Dominic [0000-0001-8420-6548], Palomäki, Jussi [0000-0001-6063-0926], Perry, Anat [0000-0003-2329-856X], Petersen, Michael Bang [0000-0002-6782-5635], Puthillam, Arathy [0000-0003-2426-8362], Rothmund, Tobias [0000-0003-2979-5129], Schmid, Petra C [0000-0002-9990-5445], Stadelmann, David [0000-0002-1211-9936], Stoica, Augustin [0000-0003-0585-1114], Stoyanov, Drozdstoy [0000-0002-9975-3680], Stoyanova, Kristina [0000-0001-8362-6444], Tewari, Shruti [0000-0003-1903-7252], Todosijević, Bojan [0000-0002-6116-993X], Torgler, Benno [0000-0002-9809-963X], Tsakiris, Manos [0000-0001-7753-7576], Tung, Hans H [0000-0001-5332-7582], Umbreș, Radu Gabriel [0000-0002-6121-4518], Vanags, Edmunds [0000-0003-1932-936X], Vlasceanu, Madalina [0000-0003-2138-1968], Vonasch, Andrew J [0000-0002-2784-5420], Zhang, Yucheng [0000-0001-9435-6734], Abad, Mohcine [0000-0002-4964-5411], Adler, Eli [0000-0002-9005-5536], Mdarhri, Hamza Alaoui [0000-0001-9831-6561], Antazo, Benedict [0000-0001-9993-8960], Ay, F Ceren [0000-0003-4444-2268], Ba, Mouhamadou El Hady [0000-0002-2707-1242], Barbosa, Sergio [0000-0003-1989-158X], Bastian, Brock [0000-0003-4619-3322], Berg, Anton [0000-0001-7143-762X], Białek, Michał [0000-0002-5062-5733], Bilancini, Ennio [0000-0002-2027-3992], Bogatyreva, Natalia [0000-0002-6024-2322], Boncinelli, Leonardo [0000-0003-0626-5133], Booth, Jonathan E [0000-0002-8563-4613], Borau, Sylvie [0000-0003-1564-0695], Buchel, Ondrej [0000-0002-0139-5513], de Carvalho, Chrissie Ferreira [0000-0002-1369-6188], Celadin, Tatiana [0000-0002-7743-3117], Cerami, Chiara [0000-0003-1974-3421], Chalise, Hom Nath [0000-0002-9301-6890], Cian, Luca [0000-0002-8051-1366], Cockcroft, Kate [0000-0002-6166-8050], Conway, Jane [0000-0003-3883-349X], Córdoba-Delgado, Mateo A [0000-0002-2264-7388], Crespi, Chiara [0000-0002-7851-9887], Crouzevialle, Marie [0000-0002-5538-6030], Cutler, Jo [0000-0003-1073-764X], Cypryańska, Marzena [0000-0001-9234-562X], Dabrowska, Justyna [0000-0002-8821-7161], Davis, Victoria H [0000-0002-7207-4629], Minda, John Paul [0000-0002-4081-010X], Dayley, Pamala N [0000-0001-8955-9502], Delouvée, Sylvain [0000-0002-4029-597X], Denkovski, Ognjan [0000-0002-9739-4100], Dezecache, Guillaume [0000-0002-9366-6287], Dhaliwal, Nathan A [0000-0002-4667-0689], Di Paolo, Roberto [0000-0002-6081-6656], Dulleck, Uwe [0000-0002-0953-5963], Ekmanis, Jānis [0000-0003-1781-1785], Etienne, Tom W [0000-0002-4299-6593], Farkhari, Fahima [0000-0002-8484-5128], Fidanovski, Kristijan [0000-0002-9006-0140], Flew, Terry [0000-0003-4485-9338], Fraser, Shona [0000-0003-1505-0652], Frempong, Raymond Boadi [0000-0002-4603-5570], Fugelsang, Jonathan [0000-0002-6342-7023], Gale, Jessica [0000-0001-5677-8629], García-Navarro, E Begoña [0000-0001-6913-8882], Gray, Kurt [0000-0001-5816-2676], Griffin, Siobhán M [0000-0002-3613-2844], Gronfeldt, Bjarki [0000-0001-9941-7903], Gruber, June [0000-0002-7789-1353], Halperin, Eran [0000-0002-3379-2935], Herzon, Volo [0000-0001-7781-1651], Hruška, Matej [0000-0002-4521-3697], Hudecek, Matthias FC [0000-0002-7696-766X], Isler, Ozan [0000-0002-4638-2230], Jangard, Simon [0000-0002-7876-4161], Jørgensen, Frederik [0000-0002-5461-912X], Keudel, Oleksandra [0000-0001-6322-3103], Koppel, Lina [0000-0002-6302-0047], Koverola, Mika [0000-0001-8227-6120], Kunnari, Anton [0000-0002-2951-6399], Leota, Josh [0000-0002-7714-4630], Lermer, Eva [0000-0002-6600-9580], Li, Chunyun [0000-0001-5909-0889], Longoni, Chiara [0000-0002-4945-4957], McCashin, Darragh [0000-0003-2686-2111], Mikloušić, Igor [0000-0002-6539-2901], Monroy-Fonseca, César [0000-0003-4696-8159], Morales-Marente, Elena [0000-0002-1227-9606], Moreau, David [0000-0002-1957-1941], Muda, Rafał [0000-0003-4953-6642], Myer, Annalisa [0000-0002-2363-4757], Nash, Kyle [0000-0003-0461-3835], Nitschke, Jonas P [0000-0002-3244-8585], Nurse, Matthew S [0000-0003-1787-5914], de Mello, Victoria Oldemburgo [0000-0003-2867-8529], Palacios-Galvez, Maria Soledad [0000-0002-6802-6202], Pan, Yafeng [0000-0002-5633-8313], Papp, Zsófia [0000-0001-6257-0568], Pärnamets, Philip [0000-0001-8360-9097], Paruzel-Czachura, Mariola [0000-0002-8716-9778], Perander, Silva [0000-0001-6711-8079], Pitman, Michael [0000-0001-5532-5388], Raza, Ali [0000-0002-2438-6054], Rêgo, Gabriel Gaudencio [0000-0003-3304-4723], Robertson, Claire [0000-0001-8403-6358], Rodríguez-Pascual, Iván [0000-0002-5385-3643], Saikkonen, Teemu [0000-0001-9619-3270], Salvador-Ginez, Octavio [0000-0002-1652-8788], Sampaio, Waldir M [0000-0002-6066-4314], Santi, Gaia Chiara [0000-0002-9253-6122], Schultner, David [0000-0003-2253-4065], Schutte, Enid [0000-0002-6653-5409], Scott, Andy [0000-0002-3294-0078], Skali, Ahmed [0000-0002-4753-3280], Stefaniak, Anna [0000-0002-1706-7784], Sternisko, Anni [0000-0002-2507-3076], Strickland, Brent [0000-0002-7573-3722], Thomas, Jeffrey P [0000-0002-5939-5559], Tinghög, Gustav [0000-0002-8159-1249], Tucciarelli, Raffaele [0000-0002-0342-308X], Tyrala, Michael [0000-0001-5268-8319], Ungson, Nick D [0000-0003-2494-4498], Uysal, Mete Sefa [0000-0002-8698-9213], Van Rooy, Dirk [0000-0003-2525-5408], Västfjäll, Daniel [0000-0003-2873-4500], Vieira, Joana B [0000-0001-7335-4588], von Sikorski, Christian [0000-0002-3787-8277], Walker, Alexander C [0000-0003-1431-6770], Watermeyer, Jennifer [0000-0001-7918-8832], Willardt, Robin [0000-0002-2495-3450], Wohl, Michael JA [0000-0001-6945-5562], Wójcik, Adrian Dominik [0000-0002-7073-6019], Wu, Kaidi [0000-0001-6881-7437], Yamada, Yuki [0000-0003-1431-568X], Yilmaz, Onurcan [0000-0002-6094-7162], Yogeeswaran, Kumar [0000-0002-1978-5077], Ziemer, Carolin-Theresa [0000-0002-0794-7702], Zwaan, Rolf A [0000-0001-9967-7879], Boggio, Paulo Sergio [0000-0002-6109-0447], Van Lange, Paul AM [0000-0001-7774-6984], Prasad, Rajib [0000-0003-0913-1624], Onderco, Michal [0000-0001-9911-3782], O'Madagain, Cathal [0000-0002-4086-524X], Nesh-Nash, Tarik [0000-0002-5532-9095], Kubin, Emily [0000-0003-0606-8594], Gümren, Mert [0000-0002-3298-6295], Fenwick, Ali [0000-0002-5412-9745], Ertan, Arhan S [0000-0001-9730-8391], Bernstein, Michael J [0000-0002-8083-9839], Amara, Hanane [0000-0003-0732-2320], Van Bavel, Jay Joseph [0000-0002-2520-0442], Apollo - University of Cambridge Repository, Sociale Psychologie (Psychologie, FMG), ASCoR Other Research (FMG), Department of Neuroscience and Biomedical Engineering, Aalto-yliopisto, Department of Digital Humanities, Department of Psychology and Logopedics, Cognitive Science, High Performance Cognition group, Mind and Matter, and Department of Computer Science
Subjects: Hälso- och sjukvårdsorganisation, hälsopolitik och hälsoekonomi, Economics, COVID-19, social distancing, hygiene, policy support, public health measures, J Political Science, [SHS.PSY]Humanities and Social Sciences/Psychology, psychology, Settore SECS-P/02 - Politica Economica, Q1, H Social Sciences, [STAT.ML]Statistics [stat]/Machine Learning [stat.ML], SDG 3 - Good Health and Well-being, RA0421, RA0421 Public health. Hygiene. Preventive Medicine, Machine learning, Psychology, Nationalekonomi, Settore SECS-P/01 - Economia Politica, MCC, Computer. Automation, Psykologi (exklusive tillämpad psykologi), DAS, Health Care Service and Management, Health Policy and Services and Health Economy, [SHS.SCIPO]Humanities and Social Sciences/Political science, Psychology (excluding Applied Psychology), machine learning, Settore SECS-P/03 - Scienza delle Finanze, 5171 Political Science, Human medicine, COVID-19, social distancing, hygiene, policy support, public health measures
Abstract: At the beginning of 2020, COVID-19 became a global problem. Despite all the efforts to emphasize the relevance of preventive measures, not everyone adhered to them. Thus, learning more about the characteristics determining attitudinal and behavioral responses to the pandemic is crucial to improving future interventions. In this study, we applied machine learning on the multinational data collected by the International Collaboration on the Social and Moral Psychology of COVID-19 (N = 51,404) to test the predictive efficacy of constructs from social, moral, cognitive, and personality psychology, as well as socio-demographic factors, in the attitudinal and behavioral responses to the pandemic. The results point to several valuable insights. Internalized moral identity provided the most consistent predictive contribution—individuals perceiving moral traits as central to their self-concept reported higher adherence to preventive measures. Similar results were found for morality as cooperation, symbolized moral identity, self-control, open-mindedness, and collective narcissism, while the inverse relationship was evident for the endorsement of conspiracy theories. However, we also found a non-neglible variability in the explained variance and predictive contributions with respect to macro-level factors such as the pandemic stage or cultural region. Overall, the results underscore the importance of morality-related and contextual factors in understanding adherence to public health recommendations during the pandemic., PNAS Nexus, 1 (3), ISSN:2752-6542
Published: 2022

16. R&D productivity and the nexus between product substitutability and innovation: Theory and experimental evidence

Author: Carmine Ornaghi, Miltiadis Makris, Christos A. Ioannou, Centre d'économie de la Sorbonne (CES), Université Paris 1 Panthéon-Sorbonne (UP1)-Centre National de la Recherche Scientifique (CNRS), University of Kent [Canterbury], and University of Southampton
Subjects: Organizational Behavior and Human Resource Management, Economics and Econometrics, JEL: L - Industrial Organization/L.L1 - Market Structure, Firm Strategy, and Market Performance/L.L1.L13 - Oligopoly and Other Imperfect Markets, JEL: C - Mathematical and Quantitative Methods/C.C1 - Econometric and Statistical Methods and Methodology: General/C.C1.C12 - Hypothesis Testing: General, 05 social sciences, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, Investment (macroeconomics), Duopoly, Product substitutability, Microeconomics, 0502 economics and business, JEL: C - Mathematical and Quantitative Methods/C.C7 - Game Theory and Bargaining Theory/C.C7.C72 - Noncooperative Games, Innovation theory, Economics, R&D productivity, JEL: C - Mathematical and Quantitative Methods/C.C9 - Design of Experiments/C.C9.C91 - Laboratory, Individual Behavior, Product (category theory), 050207 economics, Experiments, Productivity, Nexus (standard), 050205 econometrics
Abstract: The present study proposes a theoretical model that investigates how R&D productivity influences the relationship between product substitutability and R&D investment in a duopolistic market. We argue that the effects on R&D investment are more complex than the previous literature suggests. We show theoretically that, in unlevelled industries, the laggard’s R&D investment decreases with product substitutability regardless of the R&D productivity level. In sharp contrast, in levelled industries, whether R&D investment increases or decreases with product substitutability depends crucially on the level of the R&D productivity. We choose parameters and formulate testable predictions that we take to the laboratory. We find that subjects’ behavior is largely consistent with the model’s predictions.
Published: 2021

17. Diverse aging rates in ectothermic tetrapods provide insights for the evolution of aging and longevity

Author: Beth A. Reinke, Hugo Cayuela, Fredric J. Janzen, Jean-François Lemaître, Jean-Michel Gaillard, A. Michelle Lawing, John B. Iverson, Ditte G. Christiansen, Iñigo Martínez-Solano, Gregorio Sánchez-Montes, Jorge Gutiérrez-Rodríguez, Francis L. Rose, Nicola Nelson, Susan Keall, Alain J. Crivelli, Theodoros Nazirides, Annegret Grimm-Seyfarth, Klaus Henle, Emiliano Mori, Gaëtan Guiller, Rebecca Homan, Anthony Olivier, Erin Muths, Blake R. Hossack, Xavier Bonnet, David S. Pilliod, Marieke Lettink, Tony Whitaker, Benedikt R. Schmidt, Michael G. Gardner, Marc Cheylan, Françoise Poitevin, Ana Golubović, Ljiljana Tomović, Dragan Arsovski, Richard A. Griffiths, Jan W. Arntzen, Jean-Pierre Baron, Jean-François Le Galliard, Thomas Tully, Luca Luiselli, Massimo Capula, Lorenzo Rugiero, Rebecca McCaffery, Lisa A. Eby, Venetia Briggs-Gonzalez, Frank Mazzotti, David Pearson, Brad A. Lambert, David M. Green, Nathalie Jreidini, Claudio Angelini, Graham Pyke, Jean-Marc Thirion, Pierre Joly, Jean-Paul Léna, Anton D. Tucker, Col Limpus, Pauline Priol, Aurélien Besnard, Pauline Bernard, Kristin Stanford, Richard King, Justin Garwood, Jaime Bosch, Franco L. Souza, Jaime Bertoluci, Shirley Famelli, Kurt Grossenbacher, Omar Lenzi, Kathleen Matthews, Sylvain Boitaud, Deanna H. Olson, Tim S. Jessop, Graeme R. Gillespie, Jean Clobert, Murielle Richard, Andrés Valenzuela-Sánchez, Gary M. Fellers, Patrick M. Kleeman, Brian J. Halstead, Evan H. Campbell Grant, Phillip G. Byrne, Thierry Frétey, Bernard Le Garff, Pauline Levionnois, John C. Maerz, Julian Pichenot, Kurtuluş Olgun, Nazan Üzüm, Aziz Avcı, Claude Miaud, Johan Elmberg, Gregory P. Brown, Richard Shine, Nathan F. Bendik, Lisa O’Donnell, Courtney L. Davis, Michael J. Lannoo, Rochelle M. Stiles, Robert M. Cox, Aaron M. Reedy, Daniel A. Warner, Eric Bonnaire, Kristine Grayson, Roberto Ramos-Targarona, Eyup Baskale, David Muñoz, John Measey, F. Andre de Villiers, Will Selman, Victor Ronget, Anne M. Bronikowski, David A. W. Miller, Northeastern Illinois University, Pennsylvania State University (Penn State), Penn State System, Department of Ecology and Evolution [Lausanne], Université de Lausanne = University of Lausanne (UNIL), Iowa State University (ISU), W. K. Kellogg Biological Station (KBS), Michigan State University [East Lansing], Michigan State University System-Michigan State University System, Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Texas A&M University [College Station], Earlham College, Partenaires INRAE, Department of Evolutionary Biology and Environmental Studies, Universität Zürich [Zürich] = University of Zurich (UZH), Museo Nacional de Ciencias Naturales [Madrid] (MNCN), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Centro de Investigaciones Biológicas (CSIC), Department of Biological Sciences [Lubbock], Texas Tech University [Lubbock] (TTU), School of Biological Sciences [Wellington, New Zealand], Victoria University of Wellington, Tour du Valat, Research Institute for the conservation of Mediterranean Wetlands, Auteur indépendant, Department of Conservation Biology [UFZ Leipzig], Helmholtz Zentrum für Umweltforschung = Helmholtz Centre for Environmental Research (UFZ), Research Institute on Terrestrial Ecosystems [CNR, Italy] (IRET), Consiglio Nazionale delle Ricerche (CNR), Le Grand Momesson, Bouvron, France, Denison University, Fort Collins Science Center (FORT), US Geological Survey [Fort Collins], United States Geological Survey [Reston] (USGS)-United States Geological Survey [Reston] (USGS), University of Montana, Centre d'Études Biologiques de Chizé - UMR 7372 (CEBC), La Rochelle Université (ULR)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Forest and Rangeland Ecosystem Science Center (FRESC), Info Fauna Karch 2000, Flinders University [Adelaide, Australia], Evolutionary Biology Unit, South Australian Museum, Université Paul-Valéry - Montpellier 3 (UPVM), University of Belgrade [Belgrade], Macedonian Ecological Society, University of Kent [Canterbury], Naturalis Biodiversity Center [Leiden], CEREEP-Ecotron Ile de France (UMS 3194), Département de Biologie - ENS Paris, École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Institut d'écologie et des sciences de l'environnement de Paris (iEES Paris ), Institut de Recherche pour le Développement (IRD)-Sorbonne Université (SU)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institute for Development, Ecology, Conservation and Cooperation [Rome, Italy], Rivers State University of Science and Technology, Université de Lomé [Togo], Museo Civico di Zoologia, U.S. Geological Survey, Forest and Rangeland Ecosystem Science Center, Wildlife Biology Program, Department of Wildlife Ecology and Conservation, University of Florida, Department of Biodiversity, Conservation and Attractions [Australia], Parks and Wildlife Service of Northern Territory, Colorado State University [Fort Collins] (CSU), Redpath Museum, McGill University = Université McGill [Montréal, Canada], Kunming Institute of Botany [CAS] (KIB), Chinese Academy of Sciences [Beijing] (CAS), Macquarie University, Association Objectifs Biodiversités (OBIOS), Équipe 4 - Écophysiologie, Comportement, Conservation (E2C), Laboratoire d'Ecologie des Hydrosystèmes Naturels et Anthropisés (LEHNA), Université de Lyon-Université de Lyon-École Nationale des Travaux Publics de l'État (ENTPE)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-École Nationale des Travaux Publics de l'État (ENTPE)-Centre National de la Recherche Scientifique (CNRS), CSIRO, EcoSciences Precinct, StatiPOP, scientific consulting, Centre d’Ecologie Fonctionnelle et Evolutive (CEFE), Université Paul-Valéry - Montpellier 3 (UPVM)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Montpellier, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Université de Montpellier (UM), Conservatoire d'Espaces Naturels de Nouvelle-Aquitaine, Ohio State University [Columbus] (OSU), Northern Illinois University, California Department of Fish and Wildlife, Universidad de Oviedo [Oviedo], Department of Biology [Mato Grosso], Universidade do Estado de Mato Grosso (UNEMAT), Escola Superior de Agricultura 'Luiz de Queiroz' (ESALQ), Universidade de São Paulo = University of São Paulo (USP), Royal Melbourne Institute of Technology University (RMIT University), University of the Highlands and Islands (UHI), Naturhistorisches Museum [Bern], USDA Forest Service Rocky Mountain Forest and Range Experiment Station, United States Department of Agriculture (USDA), Deakin University [Waurn Ponds], Palmerston North Research Centre, Plant & Food Research, Station d'écologie théorique et expérimentale (SETE), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Universidad Austral de Chile, ONG Ranita de Darwin, U.S Geological Survey, Patuxent Wildlife Research Center, SO Conte Anadromous Fish Laboratory, School of Earth and Environmental Sciences [Wollongong], Faculty of Science, Medicine and Health [Wollongong], University of Wollongong [Australia]-University of Wollongong [Australia], Université de Rennes (UNIV-RENNES), Office national des forêts (ONF), University of Georgia [USA], Centre de Recherche et de Formation en Eco-éthologie (2C2A-CERFE), Université de Reims Champagne-Ardenne (URCA), Adnan Menderes Üniversitesi, University College of Kristianstad, Watershed Protection Department, Cornell Lab of Ornithology [New York], Cornell University [New York], Indiana University School of Medicine, Indiana University System, University of Virginia, Auburn University (AU), University of Richmond, Ministerio de Ciencia, Tecnología y Medio Ambiente (CITMA), Pamukkale University, Stellenbosch University, Millsaps College, Éco-Anthropologie (EA), Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS), This study was supported by National Institutes of Health grant R01AG049416 (to A.M.B., F.J.J., and D.A.W.M.). H.C. was supported as a postdoctoral researcher by the Swiss National Science Foundation (grant no. 31003A_182265)., Office National des Forêts (ONF), University of Virginia [Charlottesville], Éco-Anthropologie (EAE), National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR), Université Paul-Valéry - Montpellier 3 (UPVM)-École Pratique des Hautes Études (EPHE), Université de Toulouse (UT)-Université de Toulouse (UT)-Observatoire Midi-Pyrénées (OMP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Université de Rennes (UR), and Cornell Laboratory of Ornithology
Subjects: life history, demography, Aging, phenotype, [SDV]Life Sciences [q-bio], Longevity, tetrapod, ectothermy, phylogeny, Amphibia, Amphibians, VERTEBRADOS, evolution, Animals, animal, Multidisciplinary, nonhuman, article, Reptiles, mortality, Biological Evolution, phylogenetics, reptile, GN, [SDE]Environmental Sciences, environmental temperature, body size
Abstract: Comparative studies of mortality in the wild are necessary to understand the evolution of aging; yet, ectothermic tetrapods are underrepresented in this comparative landscape, despite their suitability for testing evolutionary hypotheses. We present a study of aging rates and longevity across wild tetrapod ectotherms, using data from 107 populations (77 species) of nonavian reptiles and amphibians. We test hypotheses of how thermoregulatory mode, environmental temperature, protective phenotypes, and pace of life history contribute to demographic aging. Controlling for phylogeny and body size, ectotherms display a higher diversity of aging rates compared with endotherms and include phylogenetically widespread evidence of negligible aging. Protective phenotypes and life-history strategies further explain macroevolutionary patterns of aging. Analyzing ectothermic tetrapods in a comparative context enhances our understanding of the evolution of aging.
Published: 2022

18. Strain engineering of the magnetic anisotropy and magnetic moment in NdFeO 3 epitaxial thin films

Author: M. A. Khaled, J. Ruvalcaba, T. Cordova-Fraga, D. C. Arnold, N. Jaouen, P. Ohresser, M. Jouiad, K. Hoummada, B. Dkhil, M. El Marssi, H. Bouyanfif, Laboratoire de Physique de la Matière Condensée - UR UPJV 2081 (LPMC), Université de Picardie Jules Verne (UPJV), Universidad de Guanajuato, University of Kent [Canterbury], Synchrotron SOLEIL (SSOLEIL), Centre National de la Recherche Scientifique (CNRS), Institut des Matériaux, de Microélectronique et des Nanosciences de Provence (IM2NP), Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Structures, Propriétés et Modélisation des solides (SPMS), Institut de Chimie du CNRS (INC)-CentraleSupélec-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), and ANR-21-CE42-0030,THz-MUFINS,Dynamiques THz dans les nanostructures et super-réseaux de matériaux multiferroïques(2021)
Subjects: [PHYS]Physics [physics], Condensed Matter - Materials Science, Physics and Astronomy (miscellaneous), Materials Science (cond-mat.mtrl-sci), FOS: Physical sciences, General Materials Science, equipment and supplies, human activities
Abstract: Strain engineering is a powerful mean for tuning the various functionalities of ABO3 perovskite oxide thin films. Rare-earth orthoferrite RFeO3 materials such as NdFeO3 (NFO) are of prime interest because of their intriguing magnetic properties as well as their technological potential applications especially as thin films. Here, using a large set of complementary and advanced techniques, we show that NFO epitaxial thin films, successfully grown by pulsed laser deposition on (001)-SrTiO3, show a strong magnetic anisotropy below a critical thickness tc of 54 nm, associated with the occurrence of structural modifications related to symmetry and domain pattern changes. By varying the tensile misfit strain through the decrease of film thickness below tc, the amplitudes of in and out-of-plane magnetization can be continuously tuned while their ratio stays constant. Furthermore, different low-temperature magnetic behaviors are evidenced for strained and relaxed films, suggesting that the strain-induced structural state impacts the magnetic phase stability.
Published: 2022

19. Selected Papers of the 22nd International Conference on Coordination Models and Languages (COORDINATION 2020)

Author: Bliudze, Simon, Bocchi, Laura, Self-adaptation for distributed services and large software systems (SPIRALS), Inria Lille - Nord Europe, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), School of Computing [Kent], and University of Kent [Canterbury]
Subjects: [INFO.INFO-PL]Computer Science [cs]/Programming Languages [cs.PL], [INFO.INFO-MA]Computer Science [cs]/Multiagent Systems [cs.MA], [INFO.INFO-ES]Computer Science [cs]/Embedded Systems, [INFO.INFO-SE]Computer Science [cs]/Software Engineering [cs.SE], [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation
Abstract: International audience
Published: 2022

20. THE SHAPING OF THE MULTIPOLAR PRE-PLANETARY NEBULA CRL 618 BY MULTIDIRECTIONAL BULLETS

Author: Smith, Michael [Centre for Astrophysics and Space Science, University of Kent, Canterbury CT2 7NH (United Kingdom)]
Published: 2016
Full Text: View/download PDF

21. Slow Growth and Increased Spontaneous Mutation Frequency in Respiratory Deficient afo1- Yeast Suppressed by a Dominant Mutation in ATP3

Author: Stefanie Jarolim, Hans Marx, Thomas Karl, Johannes Hartl, Gianni Liti, Jiri Hasek, Özge Ata, Manuela Weber, Bill Burhans, Maria Karolin Streubel, Gregor P Greslehner, Jing Li, Campbell W. Gourlay, Hannelore Breitenbach-Koller, Diethard Mattanovich, Paul J. Cullen, Florian Geltinger, Mark Rinnerthaler, Claudia Moßhammer, Jakob Vowinckel, Michael Mülleder, Michael Sauer, Michael Breitenbach, Chris M. Grant, Meryem Ralser, Sonakshi De, Christian Grabner, Markus Ralser, Victoria Doronina, Institut de Recherche sur le Cancer et le Vieillissement (IRCAN), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Sun Yat-sen University Cancer Center, University of Salzburg, University of Cambridge [UK] (CAM), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], The Francis Crick Institute [London], University of Natural Resources and Life Sciences (BOKU), Austrian Centre of Industrial Biotechnology GmbH (ACIB), Roswell Park Cancer Institute [Buffalo], University of Manchester [Manchester], Manchester Metropolitan University (MMU), University of Kent [Canterbury], Institute of Microbiology of the Czech Academy of Sciences (MBU / CAS), Czech Academy of Sciences [Prague] (CAS), University at Buffalo [SUNY] (SUNY Buffalo), and State University of New York (SUNY)
Subjects: atp3, MESH: Mutation, Saccharomyces cerevisiae Proteins, MESH: Mutation Rate, Saccharomyces cerevisiae, Investigations, QH426-470, medicine.disease_cause, DNA, Mitochondrial, 03 medical and health sciences, 0302 clinical medicine, MESH: Saccharomyces cerevisiae Proteins, Mutation Rate, medicine, Genetics, Missense mutation, saccharomyces cerevisiae, rho-zero, Mutation frequency, Molecular Biology, Genetics (clinical), [SDV.MP.MYC]Life Sciences [q-bio]/Microbiology and Parasitology/Mycology, 030304 developmental biology, Suppressor mutation, 0303 health sciences, Mutation, [SDV.GEN]Life Sciences [q-bio]/Genetics, biology, Strain (chemistry), Point mutation, MESH: DNA, Mitochondrial, biology.organism_classification, Molecular biology, MESH: Saccharomyces cerevisiae, Yeast, mutation frequency, growth velocity, 030217 neurology & neurosurgery
Abstract: A yeast deletion mutation in the nuclear-encoded gene, AFO1, which codes for a mitochondrial ribosomal protein, led to slow growth on glucose, the inability to grow on glycerol or ethanol, and loss of mitochondrial DNA and respiration. We noticed that afo1- yeast readily obtains secondary mutations that suppress aspects of this phenotype, including its growth defect. We characterized and identified a dominant missense suppressor mutation in the ATP3 gene. Comparing isogenic slowly growing rho-zero and rapidly growing suppressed afo1- strains under carefully controlled fermentation conditions showed that energy charge was not significantly different between strains and was not causal for the observed growth properties. Surprisingly, in a wild-type background, the dominant suppressor allele of ATP3 still allowed respiratory growth but increased the petite frequency. Similarly, a slow-growing respiratory deficient afo1- strain displayed an about twofold increase in spontaneous frequency of point mutations (comparable to the rho-zero strain) while the suppressed strain showed mutation frequency comparable to the respiratory-competent WT strain. We conclude, that phenotypes that result from afo1- are mostly explained by rapidly emerging mutations that compensate for the slow growth that typically follows respiratory deficiency.
Published: 2020

22. Localization and Functional Characterization of the Alternative Oxidase in Naegleria

Author: Diego Cantoni, Ashley Osborne, Najwa Taib, Gary Thompson, Rubén Martín‐Escolano, Eleanna Kazana, Elizabeth Edrich, Ian R. Brown, Simonetta Gribaldo, Campbell W. Gourlay, Anastasios D. Tsaousis, University of Kent [Canterbury], Biologie Évolutive de la Cellule Microbienne - Evolutionary Biology of the Microbial Cell, Université Paris Cité (UPCité)-Microbiologie Intégrative et Moléculaire (UMR6047), Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hub Bioinformatique et Biostatistique - Bioinformatics and Biostatistics HUB, Institut Pasteur [Paris] (IP)-Université Paris Cité (UPCité), Alfonso Martín Escudero Foundation, Gordon and Betty Moore Foundation, and Biotechnology and Biological Sciences Research Council, Grant/Award Number: BB/M009971/1
Subjects: Eukaryota, Naegleria, adaptation, confocal microscopy, Microbiology, Mitochondrial Proteins, mitochondria, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, parasitic diseases, evolution, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Oxidoreductases, Naegleria fowleri, respiration, Plant Proteins
Abstract: International audience; The alternative oxidase (AOX) is a protein involved in supporting enzymatic reactions of the Krebs cycle in instances when the canonical (cytochrome-mediated) respiratory chain has been inhibited, while allowing for the maintenance of cell growth and necessary metabolic processes for survival. Among eukaryotes, alternative oxidases have dispersed distribution and are found in plants, fungi, and protists, including Naegleria ssp. Naegleria species are free-living unicellular amoeboflagellates and include the pathogenic species of N. fowleri, the so-called "brain-eating amoeba." Using a multidisciplinary approach, we aimed to understand the evolution, localization, and function of AOX and the role that plays in Naegleria's biology. Our analyses suggest that AOX was present in last common ancestor of the genus and structure prediction showed that all functional residues are also present in Naegleria species. Using cellular and biochemical techniques, we also functionally characterize N. gruberi's AOX in its mitochondria, and we demonstrate that its inactivation affects its proliferation. Consequently, we discuss the benefits of the presence of this protein in Naegleria species, along with its potential pathogenicity role in N. fowleri. We predict that our findings will spearhead new explorations to understand the cell biology, metabolism, and evolution of Naegleria and other free-living relatives.
Published: 2022

23. Vacuum ultraviolet photoabsorption spectra of an in-situ synthesized peptide precursor: hydroxylamine on a cold astrochemical dust analogue

Author: R. Thombre, D. Gupta, S. Pavithraa, J.-I. Lo, S.-L. Chou, Y.-J. Wu, R. Ramachandran, K. K. Rahul, B.-M. Cheng, H. Hill, Anil Bhardwaj, B. N. Rajasekhar, N. J. Mason, B. Sivaraman, University of Kent [Canterbury], Institut de Physique de Rennes (IPR), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS), National Chiao Tung University (NCTU), National Synchrotron Radiation Research Center (NSRRC), Physical Research Laboratory [Ahmedabad] (PRL), Indian Space Research Organisation (ISRO), Bhabha Atomic Research Centre (BARC), Government of India, Department of Atomic Energy, Sir John and Lady Mason academic trust, PRL (Dept of Space, Govt of India), INSPIRE grant [IFA-11CH -11], J. C. Bose fellowshipDepartment of Science and Technology (India), European Union European Commission [871149], and Ministry of Science and Technology, Taiwan Ministry of Science and Technology, Taiwan [MOST 109-2639-M-009-001-ASP]
Subjects: [PHYS]Physics [physics], Molecular physics, Atomic and Molecular Physics, and Optics
Abstract: International audience; The recent discovery of hydroxylamine (NH2OH) molecule in the interstellar medium emphasizes the need to study the molecule in laboratory astrochemical ice analogues. Here, we present the first vacuum ultraviolet photoabsorption spectrum of hydroxylamine ice synthesized in-situ in an ammonia-oxygen (6:1) ice mixture irradiated by similar to 10 eV photons from synchrotron radiation source. The appearance of a new band between the 180-240 nm, with a band centered at similar to 207 nm, is assigned to the characteristic absorption of hydroxylamine molecule in the ice phase. This band maybe used in ammonia dominated, oxygen bearing, icy surfaces for the identification of hydroxylamine.
Published: 2022

24. Social alignment matters: Following pandemic guidelines is associated with better wellbeing

Author: Bahar Tuncgenc, Martha Newson, Justin Sulik, Yi Zhao, Guillaume Dezecache, Ophelia Deroy, Marwa El Zein, Nottingham Trent University, University of Oxford, University of Kent [Canterbury], Ludwig Maximilian University [Munich] (LMU), Indiana University [Bloomington], Indiana University System, Laboratoire de Psychologie Sociale et Cognitive (LAPSCO), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), University of London [London], University College of London [London] (UCL), Max Planck Institute for Human Development, and Max-Planck-Gesellschaft
Subjects: Social distancing, Adolescent, Wellbeing, Social alignment, Physical Distancing, Public Health, Environmental and Occupational Health, [SHS.PSY]Humanities and Social Sciences/Psychology, COVID-19, Anxiety, Mental Health, GN, Humans, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Female, Pandemic adherence, Pandemics, Covid-19 lockdown
Abstract: BackgroundIn response to the Covid-19 pandemic, most countries implemented physical distancing measures. Many mental health experts warned that through increasing social isolation and anxiety, these measures could negatively affect psychosocial wellbeing. However, socially aligning with others by adhering to these measures may also be beneficial for wellbeing.MethodsWe examined these two contrasting hypotheses using cross-national survey data (N = 6675) collected fortnightly from participants in 115 countries over 3 months at the beginning of the pandemic. Participants reported their wellbeing, perceptions of how vulnerable they were to Covid-19 (i.e., high risk of infection) and how much they, and others in their social circle and country, were adhering to the distancing measures.ResultsLinear mixed-effects models showed that being a woman, having lower educational attainment, living alone and perceived high vulnerability to Covid-19 were risk factors for poorer wellbeing. Being young (18–25) was associated with lower wellbeing, but longitudinal analyses showed that young people’s wellbeing improved over 3 months. In contrast to widespread views that physical distancing measures negatively affect wellbeing, results showed that following the guidelines was positively associated with wellbeing even for people in high-risk groups.ConclusionsThese findings provide an important counterpart to the idea that pandemic containment measures such as physical distancing negatively impacted wellbeing unequivocally. Despite the overall burden of the pandemic on psychosocial wellbeing, social alignment with others can still contribute to positive wellbeing. The pandemic has manifested our propensity to adapt to challenges, particularly highlighting how social alignment can forge resilience.
Published: 2022

25. National identity predicts public health support during a global pandemic

Author: Van Bavel, Jay J., Cichocka, Aleksandra, Capraro, Valerio, Sjåstad, Hallgeir, Nezlek, John B., Pavlović, Tomislav, Alfano, Mark, Gelfand, Michele J., Azevedo, Flavio, Birtel, Michèle D., Cislak, Aleksandra, Lockwood, Patricia L., Ross, Robert Malcolm, Abts, Koen, Agadullina, Elena, Aruta, John Jamir Benzon, Besharati, Sahba Nomvula, Bor, Alexander, Choma, Becky L., Crabtree, Charles David, Cunningham, William A., De, Koustav, Ejaz, Waqas, Elbaek, Christian T., Findor, Andrej, Flichtentrei, Daniel, Franc, Renata, Gjoneska, Biljana, Gruber, June, Gualda, Estrella, Horiuchi, Yusaku, Huynh, Toan Luu Duc, Ibanez, Agustin, Imran, Mostak Ahamed, Israelashvili, Jacob, Jasko, Katarzyna, Kantorowicz, Jaroslaw, Kantorowicz-Reznichenko, Elena, Krouwel, André, Laakasuo, Michael, Lamm, Claus, Leygue, Caroline, Lin, Ming-Jen, Mansoor, Mohammad Sabbir, Marie, Antoine, Mayiwar, Lewend, Mazepus, Honorata, McHugh, Cillian, Minda, John Paul, Mitkidis, Panagiotis, Olsson, Andreas, Otterbring, Tobias, Packer, Dominic J., Perry, Anat, Petersen, Michael Bang, Puthillam, Arathy, Riaño-Moreno, Julián C., Rothmund, Tobias, Santamaría-García, Hernando, Schmid, Petra C., Stoyanov, Drozdstoy, Tewari, Shruti, Todosijević, Bojan, Tsakiris, Manos, Tung, Hans H., Umbreș, Radu G., Vanags, Edmunds, Vlasceanu, Madalina, Vonasch, Andrew, Yucel, Meltem, Zhang, Yucheng, Abad, Mohcine, Adler, Eli, Akrawi, Narin, Mdarhri, Hamza Alaoui, Amara, Hanane, Amodio, David M., Antazo, Benedict G., Apps, Matthew, Ay, F. Ceren, Ba, Mouhamadou Hady, Barbosa, Sergio, Bastian, Brock, Berg, Anton, Bernal-Zárate, Maria P., Bernstein, Michael, Białek, Michał, Bilancini, Ennio, Bogatyreva, Natalia, Boncinelli, Leonardo, Booth, Jonathan E., Borau, Sylvie, Buchel, Ondrej, Cameron, C. Daryl, Carvalho, Chrissie F., Celadin, Tatiana, Cerami, Chiara, Chalise, Hom Nath, Cheng, Xiaojun, Cian, Luca, Cockcroft, Kate, Conway, Jane, Córdoba-Delgado, Mateo Andres, Crespi, Chiara, Crouzevialle, Marie, Cutler, Jo, Cypryańska, Marzena, Dabrowska, Justyna, Daniels, Michael A., Davis, Victoria H., Dayley, Pamala N., Delouvee, Sylvain, Denkovski, Ognjan, Dezecache, Guillaume, Dhaliwal, Nathan A., Diato, Alelie B., Di Paolo, Roberto, Drosinou, Marianna, Dulleck, Uwe, Ekmanis, Jānis, Ertan, Arhan S., Etienne, Tom W., Farhana, Hapsa Hossain, Farkhari, Fahima, Farmer, Harry, Fenwick, Ali, Fidanovski, Kristijan, Flew, Terry, Fraser, Shona, Frempong, Raymond Boadi, Fugelsang, Jonathan A., Gale, Jessica, Garcia-Navarro, E. Begoña, Garladinne, Prasad, Ghajjou, Oussama, Gkinopoulos, Theofilos, Gray, Kurt, Griffin, Siobhán M., Gronfeldt, Bjarki, Gümren, Mert, Gurung, Ranju Lama, Halperin, Eran, Harris, Elizabeth, Herzon, Volo, Hruška, Matej, Huang, Guanxiong, Hudecek, Matthias F. C., Isler, Ozan, Jangard, Simon, Jørgensen, Frederik J., Kachanoff, Frank, Kahn, John, Dangol, Apsara Katuwal, Keudel, Oleksandra, Koppel, Lina, Koverola, Mika, Kubin, Emily, Kunnari, Anton, Kutiyski, Yordan, Laguna, Oscar, Leota, Josh, Lermer, Eva, Levy, Jonathan, Levy, Neil, Li, Chunyun, Long, Elizabeth U., Longoni, Chiara, Maglić, Marina, McCashin, Darragh, Metcalf, Alexander L., Mikloušić, Igor, El Mimouni, Soulaimane, Miura, Asako, Molina-Paredes, Juliana, Monroy-Fonseca, César, Morales-Marente, Elena, Moreau, David, Muda, Rafał, Myer, Annalisa, Nash, Kyle, Nesh-Nash, Tarik, Nitschke, Jonas P., Nurse, Matthew S., Ohtsubo, Yohsuke, Oldemburgo De Mello, Victoria, O’Madagain, Cathal, Onderco, Michal, Palacios-Galvez, M. Soledad, Palomäki, Jussi, Pan, Yafeng, Papp, Zsófia, Pärnamets, Philip, Paruzel-Czachura, Mariola, Pavlović, Zoran, Payán-Gómez, César, Perander, Silva, Pitman, Michael Mark, Prasad, Rajib, Pyrkosz-Pacyna, Joanna, Rathje, Steve, Raza, Ali, Rêgo, Gabriel G., Rhee, Kasey, Robertson, Claire E., Rodríguez-Pascual, Iván, Saikkonen, Teemu, Salvador-Ginez, Octavio, Sampaio, Waldir M., Santi, Gaia C., Santiago-Tovar, Natalia, Savage, David, Scheffer, Julian A., Schönegger, Philipp, Schultner, David T., Schutte, Enid M., Scott, Andy, Sharma, Madhavi, Sharma, Pujan, Skali, Ahmed, Stadelmann, David, Stafford, Clara Alexandra, Stanojević, Dragan, Stefaniak, Anna, Sternisko, Anni, Stoica, Agustin, Stoyanova, Kristina K., Strickland, Brent, Sundvall, Jukka, Thomas, Jeffrey P., Tinghög, Gustav, Torgler, Benno, Traast, Iris J., Tucciarelli, Raffaele, Tyrala, Michael, Ungson, Nick D., Uysal, Mete S., Van Lange, Paul A. M., Van Prooijen, Jan-Willem, Van Rooy, Dirk, Västfjäll, Daniel, Verkoeijen, Peter, Vieira, Joana B., Von Sikorski, Christian, Walker, Alexander Cameron, Watermeyer, Jennifer, Wetter, Erik, Whillans, Ashley, Willardt, Robin, Wohl, Michael J. A., Wójcik, Adrian Dominik, Wu, Kaidi, Yamada, Yuki, Yilmaz, Onurcan, Yogeeswaran, Kumar, Ziemer, Carolin-Theresa, Zwaan, Rolf A., Boggio, Paulo S., Van Bavel, Jay J., Cichocka, Aleksandra, Capraro, Valerio, Sjåstad, Hallgeir, Nezlek, John B., Pavlović, Tomislav, Alfano, Mark, Gelfand, Michele J., Azevedo, Flavio, Birtel, Michèle D., Cislak, Aleksandra, Lockwood, Patricia L., Ross, Robert Malcolm, Abts, Koen, Agadullina, Elena, Aruta, John Jamir Benzon, Besharati, Sahba Nomvula, Bor, Alexander, Choma, Becky L., Crabtree, Charles David, Cunningham, William A., De, Koustav, Ejaz, Waqa, Elbaek, Christian T., Findor, Andrej, Flichtentrei, Daniel, Franc, Renata, Gjoneska, Biljana, Gruber, June, Gualda, Estrella, Horiuchi, Yusaku, Huynh, Toan Luu Duc, Ibanez, Augustin, Imran, Mostak Ahamed, Israelashvili, Jacob, Jasko, Katarzyna, Kantorowicz, Jaroslaw, Kantorowicz-Reznichenko, Elena, Krouwel, André, Laakasuo, Michael, Lamm, Clau, Leygue, Caroline, Lin, Ming-Jen, Mansoor, Mohammad Sabbir, Marie, Antoine, Mayiwar, Lewend, Mazepus, Honorata, McHugh, Cillian, Minda, John Paul, Mitkidis, Panagioti, Olsson, Andrea, Otterbring, Tobia, Packer, Dominic J., Perry, Anat, Petersen, Michael Bang, Puthillam, Arathy, Riaño-Moreno, Julián C., Rothmund, Tobia, Santamaría-García, Hernando, Schmid, Petra C., Stoyanov, Drozdstoy, Tewari, Shruti, Todosijević, Bojan, Tsakiris, Mano, Tung, Hans H., Umbreș, Radu G., Vanags, Edmund, Vlasceanu, Madalina, Vonasch, Andrew, Yucel, Meltem, Zhang, Yucheng, Abad, Mohcine, Adler, Eli, Akrawi, Narin, Mdarhri, Hamza Alaoui, Amara, Hanane, Amodio, David M., Antazo, Benedict G., Apps, Matthew, Ay, F. Ceren, Ba, Mouhamadou Hady, Barbosa, Sergio, Bastian, Brock, Berg, Anton, Bernal-Zárate, Maria P., Bernstein, Michael, Białek, Michał, Bilancini, Ennio, Bogatyreva, Natalia, Boncinelli, Leonardo, Booth, Jonathan E., Borau, Sylvie, Buchel, Ondrej, Cameron, C. Daryl, Carvalho, Chrissie F., Celadin, Tatiana, Cerami, Chiara, Chalise, Hom Nath, Cheng, Xiaojun, Cian, Luca, Cockcroft, Kate, Conway, Jane, Córdoba-Delgado, Mateo Andre, Crespi, Chiara, Crouzevialle, Marie, Cutler, Jo, Cypryańska, Marzena, Dabrowska, Justyna, Daniels, Michael A., Davis, Victoria H., Dayley, Pamala N., Delouvee, Sylvain, Denkovski, Ognjan, Dezecache, Guillaume, Dhaliwal, Nathan A., Diato, Alelie B., Di Paolo, Roberto, Drosinou, Marianna, Dulleck, Uwe, Ekmanis, Jāni, Ertan, Arhan S., Etienne, Tom W., Farhana, Hapsa Hossain, Farkhari, Fahima, Farmer, Harry, Fenwick, Ali, Fidanovski, Kristijan, Flew, Terry, Fraser, Shona, Frempong, Raymond Boadi, Fugelsang, Jonathan A., Gale, Jessica, Garcia-Navarro, E. Begoña, Garladinne, Prasad, Ghajjou, Oussama, Gkinopoulos, Theofilo, Gray, Kurt, Griffin, Siobhán M., Gronfeldt, Bjarki, Gümren, Mert, Gurung, Ranju Lama, Halperin, Eran, Harris, Elizabeth, Herzon, Volo, Hruška, Matej, Huang, Guanxiong, Hudecek, Matthias F. C., Isler, Ozan, Jangard, Simon, Jørgensen, Frederik J., Kachanoff, Frank, Kahn, John, Dangol, Apsara Katuwal, Keudel, Oleksandra, Koppel, Lina, Koverola, Mika, Kubin, Emily, Kunnari, Anton, Kutiyski, Yordan, Laguna, Oscar, Leota, Josh, Lermer, Eva, Levy, Jonathan, Levy, Neil, Li, Chunyun, Long, Elizabeth U., Longoni, Chiara, Maglić, Marina, McCashin, Darragh, Metcalf, Alexander L., Mikloušić, Igor, El Mimouni, Soulaimane, Miura, Asako, Molina-Paredes, Juliana, Monroy-Fonseca, César, Morales-Marente, Elena, Moreau, David, Muda, Rafał, Myer, Annalisa, Nash, Kyle, Nesh-Nash, Tarik, Nitschke, Jonas P., Nurse, Matthew S., Ohtsubo, Yohsuke, Oldemburgo de Mello, Victoria, O’Madagain, Cathal, Onderco, Michal, Palacios-Galvez, M. Soledad, Palomäki, Jussi, Pan, Yafeng, Papp, Zsófia, Pärnamets, Philip, Paruzel-Czachura, Mariola, Pavlović, Zoran, Payán-Gómez, César, Perander, Silva, Pitman, Michael Mark, Prasad, Rajib, Pyrkosz-Pacyna, Joanna, Rathje, Steve, Raza, Ali, Rêgo, Gabriel G., Rhee, Kasey, Robertson, Claire E., Rodríguez-Pascual, Iván, Saikkonen, Teemu, Salvador-Ginez, Octavio, Sampaio, Waldir M., Santi, Gaia C., Santiago-Tovar, Natalia, Savage, David, Scheffer, Julian A., Schönegger, Philipp, Schultner, David T., Schutte, Enid M., Scott, Andy, Sharma, Madhavi, Sharma, Pujan, Skali, Ahmed, Stadelmann, David, Stafford, Clara Alexandra, Stanojević, Dragan, Stefaniak, Anna, Sternisko, Anni, Stoica, Augustin, Stoyanova, Kristina K., Strickland, Brent, Sundvall, Jukka, Thomas, Jeffrey P., Tinghög, Gustav, Torgler, Benno, Traast, Iris J., Tucciarelli, Raffaele, Tyrala, Michael, Ungson, Nick D., Uysal, Mete S., Van Lange, Paul A. M., van Prooijen, Jan-Willem, van Rooy, Dirk, Västfjäll, Daniel, Verkoeijen, Peter, Vieira, Joana B., von Sikorski, Christian, Walker, Alexander Cameron, Watermeyer, Jennifer, Wetter, Erik, Whillans, Ashley, Willardt, Robin, Wohl, Michael J. A., Wójcik, Adrian Dominik, Wu, Kaidi, Yamada, Yuki, Yilmaz, Onurcan, Yogeeswaran, Kumar, Ziemer, Carolin-Theresa, Zwaan, Rolf A., Boggio, Paulo S., Department of Digital Humanities, Faculty Common Matters (Faculty of Arts), Cognitive Science, Helsinki Research Hub on Religion, Media and Social Change, Helsinki Social Computing Group, Doctoral Programme in Cognition, Learning, Instruction and Communication, Mind and Matter, High Performance Cognition group, Medicum, Digital Humanities, Law and Economics, Pharmacy, Public Administration, Molecular Genetics, Research Methods and Techniques, Brain and Cognition, Van Bavel, Jay J [0000-0002-2520-0442], Cichocka, Aleksandra [0000-0003-1703-1586], Sjåstad, Hallgeir [0000-0002-8730-1038], Nezlek, John B [0000-0003-4963-3637], Pavlović, Tomislav [0000-0002-4470-3715], Alfano, Mark [0000-0001-5879-8033], Azevedo, Flavio [0000-0001-9000-8513], Cislak, Aleksandra [0000-0002-9880-6947], Lockwood, Patricia L [0000-0001-7195-9559], Ross, Robert Malcolm [0000-0001-8711-1675], Abts, Koen [0000-0001-8546-8347], Agadullina, Elena [0000-0002-1505-1412], Aruta, John Jamir Benzon [0000-0003-4155-1063], Besharati, Sahba Nomvula [0000-0003-2836-7982], Bor, Alexander [0000-0002-2624-9221], Crabtree, Charles David [0000-0001-5144-8671], De, Koustav [0000-0001-9562-0672], Ejaz, Waqas [0000-0002-2492-4115], Elbaek, Christian T [0000-0002-7039-4565], Findor, Andrej [0000-0002-5896-6989], Franc, Renata [0000-0002-1909-2393], Gjoneska, Biljana [0000-0003-1200-6672], Huynh, Toan Luu Duc [0000-0002-1486-127X], Ibanez, Augustin [0000-0001-6758-5101], Imran, Mostak Ahamed [0000-0002-5101-3149], Kantorowicz, Jaroslaw [0000-0002-1186-5427], Krouwel, André [0000-0003-0952-6028], Laakasuo, Michael [0000-0003-2826-6073], Lamm, Claus [0000-0002-5422-0653], Leygue, Caroline [0000-0002-0355-1030], Lin, Ming-Jen [0000-0002-7174-2226], Mansoor, Mohammad Sabbir [0000-0002-6541-3506], Marie, Antoine [0000-0002-7958-0153], McHugh, Cillian [0000-0002-9701-3232], Minda, John Paul [0000-0002-4081-010X], Mitkidis, Panagiotis [0000-0002-9495-7369], Olsson, Andreas [0000-0001-5272-7744], Otterbring, Tobias [0000-0002-0283-8777], Perry, Anat [0000-0003-2329-856X], Petersen, Michael Bang [0000-0002-6782-5635], Riaño-Moreno, Julián C [0000-0003-4182-0550], Rothmund, Tobias [0000-0003-2979-5129], Schmid, Petra C [0000-0002-9990-5445], Stoyanov, Drozdstoy [0000-0002-9975-3680], Todosijević, Bojan [0000-0002-6116-993X], Tsakiris, Manos [0000-0001-7753-7576], Tung, Hans H [0000-0001-5332-7582], Vanags, Edmunds [0000-0003-1932-936X], Vlasceanu, Madalina [0000-0003-2138-1968], Yucel, Meltem [0000-0002-7274-5971], Zhang, Yucheng [0000-0001-9435-6734], Abad, Mohcine [0000-0002-4964-5411], Mdarhri, Hamza Alaoui [0000-0001-9831-6561], Amara, Hanane [0000-0003-0732-2320], Antazo, Benedict G [0000-0001-9993-8960], Apps, Matthew [0000-0001-5793-2202], Barbosa, Sergio [0000-0003-1989-158X], Bastian, Brock [0000-0003-4619-3322], Bernal-Zárate, Maria P [0000-0001-8232-6220], Białek, Michał [0000-0002-5062-5733], Boncinelli, Leonardo [0000-0003-0626-5133], Booth, Jonathan E [0000-0002-8563-4613], Borau, Sylvie [0000-0003-1564-0695], Buchel, Ondrej [0000-0002-0139-5513], Chalise, Hom Nath [0000-0002-9301-6890], Cian, Luca [0000-0002-8051-1366], Cockcroft, Kate [0000-0002-6166-8050], Conway, Jane [0000-0003-3883-349X], Córdoba-Delgado, Mateo Andres [0000-0002-2264-7388], Crouzevialle, Marie [0000-0002-5538-6030], Cutler, Jo [0000-0003-1073-764X], Dabrowska, Justyna [0000-0002-8821-7161], Davis, Victoria H [0000-0002-7207-4629], Dayley, Pamala N [0000-0001-8955-9502], Delouvee, Sylvain [0000-0002-4029-597X], Di Paolo, Roberto [0000-0002-6081-6656], Dulleck, Uwe [0000-0002-0953-5963], Ekmanis, Jānis [0000-0003-1781-1785], Etienne, Tom W [0000-0002-4299-6593], Farkhari, Fahima [0000-0002-8484-5128], Farmer, Harry [0000-0002-3684-0605], Fenwick, Ali [0000-0002-5412-9745], Flew, Terry [0000-0003-4485-9338], Frempong, Raymond Boadi [0000-0002-4603-5570], Gale, Jessica [0000-0001-5677-8629], Garcia-Navarro, E Begoña [0000-0001-6913-8882], Ghajjou, Oussama [0000-0002-2975-0265], Griffin, Siobhán M [0000-0002-3613-2844], Halperin, Eran [0000-0002-3379-2935], Herzon, Volo [0000-0001-7781-1651], Huang, Guanxiong [0000-0002-8588-1454], Hudecek, Matthias FC [0000-0002-7696-766X], Isler, Ozan [0000-0002-4638-2230], Jangard, Simon [0000-0002-7876-4161], Jørgensen, Frederik J [0000-0002-5461-912X], Kahn, John [0000-0002-0548-3123], Koppel, Lina [0000-0002-6302-0047], Koverola, Mika [0000-0001-8227-6120], Leota, Josh [0000-0002-7714-4630], Lermer, Eva [0000-0002-6600-9580], Maglić, Marina [0000-0002-6851-4601], Metcalf, Alexander L [0000-0001-9532-585X], Miura, Asako [0000-0002-7563-7503], Monroy-Fonseca, César [0000-0003-4696-8159], Morales-Marente, Elena [0000-0002-1227-9606], Moreau, David [0000-0002-1957-1941], Nesh-Nash, Tarik [0000-0002-5532-9095], Nitschke, Jonas P [0000-0002-3244-8585], Nurse, Matthew S [0000-0003-1787-5914], Palomäki, Jussi [0000-0001-6063-0926], Pan, Yafeng [0000-0002-5633-8313], Pavlović, Zoran [0000-0002-9231-5100], Payán-Gómez, César [0000-0002-0633-1332], Perander, Silva [0000-0001-6711-8079], Pitman, Michael Mark [0000-0001-5532-5388], Pyrkosz-Pacyna, Joanna [0000-0002-9112-8629], Raza, Ali [0000-0002-2438-6054], Rhee, Kasey [0000-0002-8562-0801], Rodríguez-Pascual, Iván [0000-0002-5385-3643], Saikkonen, Teemu [0000-0001-9619-3270], Sampaio, Waldir M [0000-0002-6066-4314], Schönegger, Philipp [0000-0001-9930-487X], Schultner, David T [0000-0003-2253-4065], Scott, Andy [0000-0002-3294-0078], Skali, Ahmed [0000-0002-4753-3280], Stadelmann, David [0000-0002-1211-9936], Stafford, Clara Alexandra [0000-0003-1716-7870], Stanojević, Dragan [0000-0002-3667-2461], Stefaniak, Anna [0000-0002-1706-7784], Sternisko, Anni [0000-0002-2507-3076], Stoica, Augustin [0000-0003-0585-1114], Sundvall, Jukka [0000-0003-4310-1162], Tinghög, Gustav [0000-0002-8159-1249], Torgler, Benno [0000-0002-9809-963X], Tucciarelli, Raffaele [0000-0002-0342-308X], Tyrala, Michael [0000-0001-5268-8319], Van Lange, Paul AM [0000-0001-7774-6984], van Prooijen, Jan-Willem [0000-0001-6236-0819], Västfjäll, Daniel [0000-0003-2873-4500], von Sikorski, Christian [0000-0002-3787-8277], Walker, Alexander Cameron [0000-0003-1431-6770], Watermeyer, Jennifer [0000-0001-7918-8832], Whillans, Ashley [0000-0002-1726-6978], Willardt, Robin [0000-0002-2495-3450], Wohl, Michael JA [0000-0001-6945-5562], Wójcik, Adrian Dominik [0000-0002-7073-6019], Wu, Kaidi [0000-0001-6881-7437], Yamada, Yuki [0000-0003-1431-568X], Yilmaz, Onurcan [0000-0002-6094-7162], Ziemer, Carolin-Theresa [0000-0002-0794-7702], Apollo - University of Cambridge Repository, Communication Science, Network Institute, Communication Choices, Content and Consequences (CCCC), Social Psychology, IBBA, A-LAB, New York University [New York] (NYU), NYU System (NYU), University of Kent [Canterbury], Middlesex University [London], Norwegian School of Economics and Business Administration, SWPS University of Social Sciences and Humanities (SWPS), College of William and Mary [Williamsburg] (WM), Ivo Pilar Institute of Social Sciences, Macquarie University, Stanford University, Friedrich-Schiller-Universität = Friedrich Schiller University Jena [Jena, Germany], University of Greenwich, University of Oxford, University of Birmingham [Birmingham], Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Vysšaja škola èkonomiki = National Research University Higher School of Economics [Moscow] (HSE), De La Salle University [Manila] (DLSU), University of the Witwatersrand [Johannesburg] (WITS), Aarhus University [Aarhus], University of Toronto, Dartmouth College [Hanover], University of Kentucky (UK), National University of Sciences and Technology [Islamabad] (NUST), Comenius University in Bratislava, IntraMed, Buenos Aires, DF, Argentina, Macedonian Academy of Sciences and Arts [Skopje, North Macedonia] (MASA), University of Colorado [Boulder], Universidad de Huelva, WHU-Otto Beisheim School of Management, University Adolfo Ibanez (Santiago), University of Dhaka, The Hebrew University of Jerusalem (HUJ), Uniwersytet Jagielloński w Krakowie = Jagiellonian University (UJ), Universiteit Leiden, Erasmus University Rotterdam, Vrije Universiteit Amsterdam [Amsterdam] (VU), Helsingin yliopisto = Helsingfors universitet = University of Helsinki, University of Vienna [Vienna], Universidad Nacional Autónoma de México = National Autonomous University of Mexico (UNAM), National Taiwan University [Taiwan] (NTU), Tribhuvan University, BI Norwegian Business School [Oslo], University of Limerick (UL), University of Western Ontario (UWO), Duke University [Durham], Karolinska Institute, University of Agder (UIA), Lehigh University [Bethlehem], Monk Prayogshala, Cooperative University of Colombia, Pontificia Universidad Javeriana (PUJ), Department of Management, Technology, and Economics [ETH Zürich] (D-MTEC), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Medical University of Plovdiv, Indian Institute of Management Indore (IMM Indore), Institute of Social Sciences Belgrade, University of London [London], University of Luxembourg [Luxembourg], National School of Political and Administrative Studies (SNSPA), University of Latvia (LU), Princeton University, University of Canterbury [Christchurch], University of Virginia, Hebei University of Technology [Tianjin], Université Mohammed VI Polytechnique [Ben Guerir] (UM6P), Institute for Research and Development-Kurdistan, University of Amsterdam [Amsterdam] (UvA), Jose Rizal Memorial State University, Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD), Universidad del Rosario [Bogota], University of Melbourne, Penn State Abington, Pennsylvania Commonwealth System of Higher Education (PCSHE)-Penn State System, University of Wrocław [Poland] (UWr), IMT Alti Studi Lucca, Università degli Studi di Firenze = University of Florence (UniFI), London School of Economics and Political Science (LSE), Toulouse School of Economics (TSE-R), Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT)-Université de Toulouse (UT)-École des hautes études en sciences sociales (EHESS)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Tilburg University [Tilburg], Netspar, Pennsylvania State University (Penn State), Penn State System, Universidade Federal de Santa Catarina = Federal University of Santa Catarina [Florianópolis] (UFSC), University of Bologna/Università di Bologna, Istituto Universitario di Studi Superiori (IUSS), Shenzhen University [Shenzhen], Institute for Advanced Study in Toulouse (IAST), Università degli Studi di Pavia = University of Pavia (UNIPV), Cracow University of Economics, University of British Columbia (UBC), University of California [Los Angeles] (UCLA), University of California (UC), Laboratoire de Psychologie : Cognition, Comportement, Communication (LP3C - EA1285), Université de Bretagne Sud (UBS)-Université de Brest (UBO)-Université de Rennes 2 (UR2)-Institut Brestois des Sciences de l'Homme et de la Société (IBSHS), Université de Brest (UBO), Laboratoire de Psychologie Sociale et Cognitive (LAPSCO), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), University of British Columbia [Vancouver], Cavite State University-General Trias City Campus, School for Advanced Studies Lucca (IMT), Queensland University of Technology [Brisbane] (QUT), Australian National University (ANU), Boǧaziçi üniversitesi = Boğaziçi University [Istanbul], Kieskompas, Hult International Business School Dubai, The University of Sydney, University of Bayreuth, University of Waterloo [Waterloo], University of Bradford, University of Crete [Heraklion] (UOC), University of North Carolina [Chapel Hill] (UNC), University of North Carolina System (UNC), Koç University, City University of Hong Kong [Hong Kong] (CUHK), University of Regensburg, Universität Duisburg-Essen = University of Duisburg-Essen [Essen], Free University of Berlin (FU), Linköping University (LIU), University of Koblenz-Landau, University of Alberta, Ludwig Maximilian University [Munich] (LMU), Interdisciplinary Center Herzliya (IDC), Aalto University, Macquarie University [Sydney], Boston University [Boston] (BU), Dublin City University [Dublin] (DCU), University of Montana, Osaka University [Osaka], SEELE Neuroscience, University of Auckland [Auckland], Maria Curie-Sklodowska University (UMCS), CUNY Graduate Center (The Graduate Center), City University of New York [New York] (CUNY), The University of Tokyo (UTokyo), Mohammed VI Polytechnic University, Hungarian Academy of Sciences (MTA), Medical University of Silesia (SUM), University of Belgrade [Belgrade], Vidyasagar College For Women, AGH University of Science and Technology [Krakow, PL] (AGH UST), University of Cambridge [UK] (CAM), Mackenzie Presbyterian University [São Paulo] (UPM), University of Turku, University of Newcastle [Callaghan, Australia] (UoN), University of St Andrews [Scotland], University of Groningen [Groningen], Carleton University, National University of Political Studies and Public Administration Bucharest, Romania (SNSPA), University of Plovdiv, Institut Jean-Nicod (IJN), Département d'Etudes Cognitives - ENS Paris (DEC), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École des hautes études en sciences sociales (EHESS)-Collège de France (CdF (institution))-Centre National de la Recherche Scientifique (CNRS)-Département de Philosophie - ENS Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Center for Research in Economics, Management and the Arts (CREMA), Partenaires INRAE, University College of London [London] (UCL), The Hong Kong University of Science and Technology, Susquehanna University, Dokuz Eylül Üniversitesi = Dokuz Eylül University [Izmir] (DEÜ), Stockholm School of Economics (SSE), Harvard Business School, Harvard University, Nicolaus Copernicus University [Toruń], University of California [San Diego] (UC San Diego), Kyushu University, Kadir Has University (KHAS), Van Bavel, Jay J. [0000-0002-2520-0442], Nezlek, John B. [0000-0003-4963-3637], Lockwood, Patricia L. [0000-0001-7195-9559], Elbaek, Christian T. [0000-0002-7039-4565], Ibanez, Agustin [0000-0001-6758-5101], Riaño-Moreno, Julián C. [0000-0003-4182-0550], Schmid, Petra C. [0000-0002-9990-5445], Tung, Hans H. [0000-0001-5332-7582], Antazo, Benedict G. [0000-0001-9993-8960], Bernal-Zárate, Maria P. [0000-0001-8232-6220], Booth, Jonathan E. [0000-0002-8563-4613], Davis, Victoria H. [0000-0002-7207-4629], Dayley, Pamala N. [0000-0001-8955-9502], Etienne, Tom W. [0000-0002-4299-6593], Garcia-Navarro, E. Begoña [0000-0001-6913-8882], Griffin, Siobhán M. [0000-0002-3613-2844], Hudecek, Matthias F. C. [0000-0002-7696-766X], Jørgensen, Frederik J. [0000-0002-5461-912X], Metcalf, Alexander L. [0000-0001-9532-585X], Nitschke, Jonas P. [0000-0002-3244-8585], Nurse, Matthew S. [0000-0003-1787-5914], Sampaio, Waldir M. [0000-0002-6066-4314], Schultner, David T. [0000-0003-2253-4065], Stoica, Agustin [0000-0003-0585-1114], Van Lange, Paul A. M. [0000-0001-7774-6984], Wohl, Michael J. A. [0000-0001-6945-5562], New York University, University of Kent, Middlesex University, Norwegian School of Economics, College of William and Mary, Institute of Social Sciences Ivo Pilar, Friedrich Schiller University Jena, SWPS University of Social Sciences and Humanities, KU Leuven, Higher School of Economics, De La Salle University Manila, University of the Witwatersrand, Aarhus University, X University, Dartmouth College, University of Kentucky, National University of Sciences and Technology Pakistan, IntraMed, Macedonian Academy of Sciences and Arts, University of Colorado Boulder, University of Huelva, Otto Beisheim School of Management, Universidad Adolfo Ibáñez, Hebrew University of Jerusalem, Jagiellonian University in Kraków, Leiden University, Vrije Universiteit Amsterdam, University of Helsinki, University of Vienna, Universidad Nacional Autónoma de México, National Taiwan University, BI Norwegian Business School, University of Limerick, Western University, Karolinska Institutet, University of Agder, Lehigh University, Universidad Cooperativa de Colombia, Universidad Javeriana, Swiss Federal Institute of Technology Zurich, Indian Institute of Management Indore, Institute of Social Sciences, Royal Holloway University of London, University of Latvia, University of Canterbury, Duke University, Hebei University of Technology, University of Kurdistan, Impact For Development, Jose Rizal University, University of Birmingham, Université Cheikh Anta Diop de Dakar, Universidad del Rosario, Pennsylvania State University, University of Wrocław, IMT Institute for Advanced Studies Lucca, University of Florence, Birkbeck University of London, Toulouse Business School, Tilburg University, Universidade Federal de Santa Catarina, Universita di Bologna, University of Pavia, Shenzhen University, Université Toulouse 1 Capitole, IRCCS Fondazione Istituto Neurologico Casimiro Mondino - Pavia, University of British Columbia, University of California Los Angeles, University of Rennes 2, University of Amsterdam, Université Clermont Auvergne, Cavite State University, Queensland University of Technology, Bogazici University, University of Sydney, University of Waterloo, University of North Carolina at Chapel Hill, Koc University, City University of Hong Kong, Free University of Berlin, Linköping University, Ludwig Maximilian University of Munich, Department of Neuroscience and Biomedical Engineering, Boston University, Dublin City University, Osaka University, University of Auckland, Maria Curie-Sklodowska University, Australian National University, The University of Tokyo, Hungarian Academy of Sciences, University of Silesia in Katowice, University of Belgrade, University of Calcutta, AGH University of Science and Technology, University of Cambridge, Universidade Presbiteriana Mackenzie, University of Newcastle, University of St Andrews, University of Groningen, National School of Political and Administrative Studies, University College London, Hong Kong University of Science and Technology, Dokuz Eylul University, Stockholm School of Economics, Nicolaus Copernicus University in Toruń, University of California San Diego, Kadir Has University, Aalto-yliopisto, University of St Andrews. School of International Relations, University of St Andrews. School of Psychology and Neuroscience, Van Bavel, J, Cichocka, A, Capraro, V, Sjastad, H, Nezlek, J, Pavlovic, T, Alfano, M, Gelfand, M, Azevedo, F, Birtel, M, Cislak, A, Lockwood, P, Ross, R, Abts, K, Agadullina, E, Aruta, J, Besharati, S, Bor, A, Choma, B, Crabtree, C, Cunningham, W, De, K, Ejaz, W, Elbaek, C, Findor, A, Flichtentrei, D, Franc, R, Gjoneska, B, Gruber, J, Gualda, E, Horiuchi, Y, Huynh, T, Ibanez, A, Imran, M, Israelashvili, J, Jasko, K, Kantorowicz, J, Kantorowicz-Reznichenko, E, Krouwel, A, Laakasuo, M, Lamm, C, Leygue, C, Lin, M, Mansoor, M, Marie, A, Mayiwar, L, Mazepus, H, Mchugh, C, Minda, J, Mitkidis, P, Olsson, A, Otterbring, T, Packer, D, Perry, A, Petersen, M, Puthillam, A, Riano-Moreno, J, Rothmund, T, Santamaria-Garcia, H, Schmid, P, Stoyanov, D, Tewari, S, Todosijevic, B, Tsakiris, M, Tung, H, Umbres, R, Vanags, E, Vlasceanu, M, Vonasch, A, Yucel, M, Zhang, Y, Abad, M, Adler, E, Akrawi, N, Mdarhri, H, Amara, H, Amodio, D, Antazo, B, Apps, M, Ay, F, Ba, M, Barbosa, S, Bastian, B, Berg, A, Bernal-Zarate, M, Bernstein, M, Bialek, M, Bilancini, E, Bogatyreva, N, Boncinelli, L, Booth, J, Borau, S, Buchel, O, Cameron, C, Carvalho, C, Celadin, T, Cerami, C, Chalise, H, Cheng, X, Cian, L, Cockcroft, K, Conway, J, Cordoba-Delgado, M, Crespi, C, Crouzevialle, M, Cutler, J, Cypryanska, M, Dabrowska, J, Daniels, M, Davis, V, Dayley, P, Delouvee, S, Denkovski, O, Dezecache, G, Dhaliwal, N, Diato, A, Di Paolo, R, Drosinou, M, Dulleck, U, Ekmanis, J, Ertan, A, Etienne, T, Farhana, H, Farkhari, F, Farmer, H, Fenwick, A, Fidanovski, K, Flew, T, Fraser, S, Frempong, R, Fugelsang, J, Gale, J, Garcia-Navarro, E, Garladinne, P, Ghajjou, O, Gkinopoulos, T, Gray, K, Griffin, S, Gronfeldt, B, Gumren, M, Gurung, R, Halperin, E, Harris, E, Herzon, V, Hruska, M, Huang, G, Hudecek, M, Isler, O, Jangard, S, Jorgensen, F, Kachanoff, F, Kahn, J, Dangol, A, Keudel, O, Koppel, L, Koverola, M, Kubin, E, Kunnari, A, Kutiyski, Y, Laguna, O, Leota, J, Lermer, E, Levy, J, Levy, N, Li, C, Long, E, Longoni, C, Maglic, M, Mccashin, D, Metcalf, A, Miklousic, I, El Mimouni, S, Miura, A, Molina-Paredes, J, Monroy-Fonseca, C, Morales-Marente, E, Moreau, D, Muda, R, Myer, A, Nash, K, Nesh-Nash, T, Nitschke, J, Nurse, M, Ohtsubo, Y, Oldemburgo de Mello, V, O'Madagain, C, Onderco, M, Palacios-Galvez, M, Palomaki, J, Pan, Y, Papp, Z, Parnamets, P, Paruzel-Czachura, M, Pavlovic, Z, Payan-Gomez, C, Perander, S, Pitman, M, Prasad, R, Pyrkosz-Pacyna, J, Rathje, S, Raza, A, Rego, G, Rhee, K, Robertson, C, Rodriguez-Pascual, I, Saikkonen, T, Salvador-Ginez, O, Sampaio, W, Santi, G, Santiago-Tovar, N, Savage, D, Scheffer, J, Schonegger, P, Schultner, D, Schutte, E, Scott, A, Sharma, M, Sharma, P, Skali, A, Stadelmann, D, Stafford, C, Stanojevic, D, Stefaniak, A, Sternisko, A, Stoica, A, Stoyanova, K, Strickland, B, Sundvall, J, Thomas, J, Tinghog, G, Torgler, B, Traast, I, Tucciarelli, R, Tyrala, M, Ungson, N, Uysal, M, Van Lange, P, van Prooijen, J, van Rooy, D, Vastfjall, D, Verkoeijen, P, Vieira, J, von Sikorski, C, Walker, A, Watermeyer, J, Wetter, E, Whillans, A, Willardt, R, Wohl, M, Wojcik, A, Wu, K, Yamada, Y, Yilmaz, O, Yogeeswaran, K, Ziemer, C, Zwaan, R, and Boggio, P
Subjects: IMAGE, Health Behavior, COVID-19, national identity, public health, pandemic, cross-cultural, Collective narcissism, Settore SECS-P/02 - Politica Economica, health behavior, Sociology, RA0421 Public health. Hygiene. Preventive Medicine, Settore SECS-P/01 - Economia Politica, public health behaviours, COVID-19, collective behaviour, Public health, [SHS.SOCIO]Humanities and Social Sciences/Sociology, Social Identification, 706/689/477/2811, article, Social identity, Public Health, Global Health, Social Medicine and Epidemiology, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, 3142 Public health care science, environmental and occupational health, VDP::Medisinske Fag: 700::Helsefag: 800, 5141 Sociology, Settore SECS-P/03 - Scienza delle Finanze, National identity, Human, Cross-Cultural Comparison, BF Psychology, Science, COVID-19 pandemic, BF, national narcissism, HV Social pathology. Social and public welfare. Criminology, Humans, Leadership, Pandemics, Public Health, SARS-CoV-2, Self Report, Social Conformity, Human development, 692/699/255/2514, SDG 3 - Good Health and Well-being, Human behaviour, political ideology, COLLECTIVE NARCISSISM, SOCIAL IDENTITY, MCC, Pandemic, IDENTIFICATION, DAS, [SHS.SCIPO]Humanities and Social Sciences/Political science, Coronavirus, MODEL, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, Viral infection, Idenfication, Image, RA Public aspects of medicine, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Human medicine, RA, Model
Abstract: Funder: Research Council of Norway through its Centres of Excellence Scheme, FAIR project No 262675, Funder: J. William Fulbright Program, Funder: Institute for Lifecourse Development, University of Greenwich, Funder: Economic Social Research Council Impact Acceleration Award, University of Oxford, Funder: Institute of Social Sciences Ivo Pilar, Funder: Academy of Finland (Suomen Akatemia); doi: https://doi.org/10.13039/501100002341, Funder: Universität Wien (University of Vienna); doi: https://doi.org/10.13039/501100003065, Funder: Ministry of Science and Technology, Taiwan (Ministry of Science and Technology of Taiwan); doi: https://doi.org/10.13039/501100004663, Funder: NOMIS Stiftung (NOMIS Foundation); doi: https://doi.org/10.13039/501100008483, Funder: Princeton Graduate Student Research Funding (Program in Cognitive Science), Funder: Corruption Laboratory on Ethics, Accountability, and the Rule of Law (CLEAR), University of Virginia, Funder: Project Pro.Co.P.E., IMT School (PAI2019), Funder: Italian Ministry of University and Research - PRIN 2017 (20178293XT), Funder: Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada (Conseil de Recherches en Sciences Naturelles et en Génie du Canada); doi: https://doi.org/10.13039/501100000038, Funder: Australian Research Council (DP180102384), Funder: Ernst and Young (EY); doi: https://doi.org/10.13039/501100003064, Changing collective behaviour and supporting non-pharmaceutical interventions is an important component in mitigating virus transmission during a pandemic. In a large international collaboration (Study 1, N = 49,968 across 67 countries), we investigated self-reported factors associated with public health behaviours (e.g., spatial distancing and stricter hygiene) and endorsed public policy interventions (e.g., closing bars and restaurants) during the early stage of the COVID-19 pandemic (April-May 2020). Respondents who reported identifying more strongly with their nation consistently reported greater engagement in public health behaviours and support for public health policies. Results were similar for representative and non-representative national samples. Study 2 (N = 42 countries) conceptually replicated the central finding using aggregate indices of national identity (obtained using the World Values Survey) and a measure of actual behaviour change during the pandemic (obtained from Google mobility reports). Higher levels of national identification prior to the pandemic predicted lower mobility during the early stage of the pandemic (r = −0.40). We discuss the potential implications of links between national identity, leadership, and public health for managing COVID-19 and future pandemics.
Published: 2022

26. Glossary of terms relating to electronic, photonic and magnetic properties of polymers (IUPAC Recommendations 2021)

Author: Jiří Vohlídal, François Schué, Richard G. Jones, Natalie Stingelin, Roger C. Hiorns, Christine Luscombe, Carlos Frederico de Oliveira Graeff, Michael G. Walter, Charles University, Universidade Estadual Paulista (UNESP), Univ Pau and Pays Adour, University of Kent, Okinawa Institute of Science and Technology, Science et Techniques du Languedoc, Imperial College, University of North Carolina at Charlotte, Charles University [Prague] (CU), Universidade Estadual Paulista Júlio de Mesquita Filho = São Paulo State University (UNESP), Institut des sciences analytiques et de physico-chimie pour l'environnement et les materiaux (IPREM), Université de Pau et des Pays de l'Adour (UPPA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), University of Kent [Canterbury], Okinawa Institute of Science and Technology Graduate University, Organisation moléculaire (évolution et matériaux fluores) (OMEMF), Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), Imperial College London, University of North Carolina [Charlotte] (UNC), and University of North Carolina System (UNC)
Subjects: optical properties, Glossary, Electric properties, molecular electronics, General Chemical Engineering, Chemical nomenclature, Nanotechnology, 02 engineering and technology, 01 natural sciences, chemistry.chemical_classification, Organic electronics, Quantitative Biology::Biomolecules, 010405 organic chemistry, business.industry, Molecular electronics, General Chemistry, Polymer, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Condensed Matter::Soft Condensed Matter, organic electronics, [CHIM.POLY]Chemical Sciences/Polymers, chemistry, functional polymers, magnetic properties, Functional polymers, Photonics, 0210 nano-technology, business
Abstract: Made available in DSpace on 2022-05-01T11:07:20Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-01-01 These recommendations are specifically for polymers and polymer systems showing a significant response to an electromagnetic field or one of its components (electric field or magnetic field), i.e., for electromagnetic-field-responsive polymer materials. The structures, processes, phenomena and quantities relating to this interdisciplinary field of materials science and technology are herein defined. Definitions are unambiguously explained and harmonized for wide acceptance by the chemistry, physics, polymer and materials science communities. A survey of typical electromagnetic-field-responsive polymers is included. Department of Physical and Macromolecular Chemistry Faculty of Sciences Charles University, Albertov 2030 DF-FC UNESP - Universidade Estadual Paulista, Av. Eng. Luiz Edmundo Carrijo Coube 14-01 Institut des Science Analytiques et Physico-Chimie Pour l'Environnement et les Materiaux CNRS Univ Pau and Pays Adour University of Kent Pi-Conjugated Polymer Unit Okinawa Institute of Science and Technology, Onna-son Organisation Moléculaire Evolution et Matériaux Fluores UMR CNRS 5073 Laboratoire de Chimie Macromoléculaire Université Montpellier II Science et Techniques du Languedoc, Place Eugène Bataillon, Cedex 5 Department of Materials Centre of Plastic Electronics (CPE) Imperial College, Exhibition Road Department of Chemistry University of North Carolina at Charlotte DF-FC UNESP - Universidade Estadual Paulista, Av. Eng. Luiz Edmundo Carrijo Coube 14-01
Published: 2022

27. Functional dynamics of a single tryptophan residue in a BLUF protein revealed by fluorescence spectroscopy

Author: Ildiko Pecsi, Steve R. Meech, James N. Iuliano, Agnieszka A. Gil, Marten H. Vos, Andras Lukacs, Peter J. Tonge, Sofia M. Kapetanaki, Jinnette Tolentino Collado, József Orbán, Miklós Nyitrai, Zsuzsanna Fekete, Katalin Raics, Robert Kapronczai, Kristof Karadi, Gregory M. Greetham, Departement of Biosciences, University of Kent [Canterbury], Laboratoire d'Optique et Biosciences (LOB), and École polytechnique (X)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: 0301 basic medicine, Light, Population, Biophysics, Molecular Conformation, lcsh:Medicine, Flavin group, Molecular Dynamics Simulation, Photoreceptors, Microbial, 010402 general chemistry, Biochemistry, 01 natural sciences, Article, Fluorescence spectroscopy, 03 medical and health sciences, Bacterial Proteins, Flavins, Fluorescence Resonance Energy Transfer, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, education, lcsh:Science, BLUF domain, education.field_of_study, Multidisciplinary, Flavoproteins, Chemistry, lcsh:R, Tryptophan, Hydrogen Bonding, Fluorescence, 0104 chemical sciences, [SDV.BBM.BP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biophysics, 030104 developmental biology, Förster resonance energy transfer, lcsh:Q, Fluorescence anisotropy
Abstract: Blue Light Using Flavin (BLUF) domains are increasingly being adopted for use in optogenetic constructs. Despite this, much remains to be resolved on the mechanism of their activation. The advent of unnatural amino acid mutagenesis opens up a new toolbox for the study of protein structural dynamics. The tryptophan analogue, 7-aza-Trp (7AW) was incorporated in the BLUF domain of the Activation of Photopigment and pucA (AppA) photoreceptor in order to investigate the functional dynamics of the crucial W104 residue during photoactivation of the protein. The 7-aza modification to Trp makes selective excitation possible using 310 nm excitation and 380 nm emission, separating the signals of interest from other Trp and Tyr residues. We used Förster energy transfer (FRET) between 7AW and the flavin to estimate the distance between Trp and flavin in both the light- and dark-adapted states in solution. Nanosecond fluorescence anisotropy decay and picosecond fluorescence lifetime measurements for the flavin revealed a rather dynamic picture for the tryptophan residue. In the dark-adapted state, the major population of W104 is pointing away from the flavin and can move freely, in contrast to previous results reported in the literature. Upon blue-light excitation, the dominant tryptophan population is reorganized, moves closer to the flavin occupying a rigidly bound state participating in the hydrogen-bond network around the flavin molecule.
Published: 2020

28. Glottal Flow Synthesis for Whisper-to-Speech Conversion

Author: Ian McLoughlin, Olivier Perrotin, GIPSA - Cognitive Robotics, Interactive Systems, & Speech Processing (GIPSA-CRISSP), GIPSA Pôle Parole et Cognition (GIPSA-PPC), Grenoble Images Parole Signal Automatique (GIPSA-lab), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-Grenoble Images Parole Signal Automatique (GIPSA-lab), Université Grenoble Alpes (UGA), University of Kent [Canterbury], This work was supported by the French National Research Agency in the framework of the 'Investissements d’avenir' Programs ANR-15-IDEX-02 and ANR-11-LABX-0025-01, ANR-15-IDEX-0002,UGA,IDEX UGA(2015), and ANR-11-LABX-0025,PERSYVAL-lab,Systemes et Algorithmes Pervasifs au confluent des mondes physique et numérique(2011)
Subjects: Glottis, Acoustics and Ultrasonics, Computer science, Speech recognition, Laryngectomy, Speech synthesis, computer.software_genre, 01 natural sciences, Glottal Flow Model, 030507 speech-language pathology & audiology, 03 medical and health sciences, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, 0103 physical sciences, Computer Science (miscellaneous), medicine, [INFO.INFO-HC]Computer Science [cs]/Human-Computer Interaction [cs.HC], Electrical and Electronic Engineering, 010301 acoustics, Vocal source excitation, Glottal flow, Computational Mathematics, Improved performance, Laryngeal Disorder, medicine.anatomical_structure, Vocal folds, Whisper-to-speech conversion, Voice, 0305 other medical science, computer, Vocal tract
Abstract: International audience; Whisper-to-speech conversion is motivated by laryngeal disorders, in which malfunction of the vocal folds leads to loss of voicing. Many patients with laryngeal disorders can still produce functional whispers, since these are characterised by the absence of vocal fold vibration. Whispers therefore constitute a common ground for speech rehabilitation across many kinds of laryngeal disorder. Whisper-to-speech conversion involves recreating natural-sounding speech from recorded whispers, and is a non-invasive and non-surgical rehabilitation that can maintain a natural method of speaking, unlike the existing methods of rehabilitation. This paper proposes a new rule-based method for whisper-to-speech conversion that replaces the noisy whisper sound source with a synthesised speech-like harmonic source, while maintaining the vocal tract component unaltered. In particular, a novel glottal source generator is developed in which whisper information is used to parameterise the excitation through a high-quality glottis model. Evaluation of the system against the standard pulse train excitation method reveals significantly improved performance. Since our method is glottis-based, it is potentially compatible with the many existing vocal tract component adaptation systems.
Published: 2020

29. A Kiloparsec-scale Molecular Wave in the Inner Galaxy: Feather of the Milky Way?

Author: Ralf S. Klessen, Dario Colombo, M. Mattern, Peter Schilke, V. S. Veena, Álvaro Sánchez-Monge, James Urquhart, Mattia C. Sormani, F. Schuller, Timea Csengeri, Universität zu Köln, Centre de résonance magnétique biologique et médicale (CRMBM), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS), Max-Planck-Institut für Radioastronomie (MPIFR), IFP Energies nouvelles (IFPEN), FEMIS 2021, Laboratoire d'Astrophysique de Bordeaux [Pessac] (LAB), Université de Bordeaux (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Centre for Astrophysics and Planetary Science [Canterbury] (CAPS), University of Kent [Canterbury], Universität zu Köln = University of Cologne, and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)
Subjects: Galaxy structure, Aspect ratio, Milky Way, FOS: Physical sciences, Norma Arm, Astrophysics, Kinematics, Astrophysics::Cosmology and Extragalactic Astrophysics, Milky Way Galaxy, 01 natural sciences, Protein filament, Interstellar medium, 0103 physical sciences, QB460, 010303 astronomy & astrophysics, Galaxy kinematics, Astrophysics::Galaxy Astrophysics, Physics, Spiral galaxy, [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], 010308 nuclear & particles physics, Galactic Center, Astronomy and Astrophysics, Astrophysics - Astrophysics of Galaxies, Galaxy, [PHYS.ASTR.GA]Physics [physics]/Astrophysics [astro-ph]/Galactic Astrophysics [astro-ph.GA], Space and Planetary Science, Astrophysics of Galaxies (astro-ph.GA), Giant molecular clouds, Submillimeter astronomy
Abstract: We report the discovery of a velocity coherent, kpc-scale molecular structure towards the Galactic center region with an angular extent of 30deg and an aspect ratio of 60:1. The kinematic distance of the CO structure ranges between 4.4 to 6.5 kpc. Analysis of the velocity data and comparison with the existing spiral arm models support that a major portion of this structure is either a sub-branch of the Norma arm or an inter-arm giant molecular filament, likely to be a kpc-scale feather (or spur) of the Milky Way, similar to those observed in nearby spiral galaxies. The filamentary cloud is at least 2.0 kpc in extent, considering the uncertainties in the kinematic distances, and it could be as long as 4 kpc. The vertical distribution of this highly elongated structure reveals a pattern similar to that of a sinusoidal wave. The exact mechanisms responsible for the origin of such a kpc-scale filament and its wavy morphology remains unclear. The distinct wave-like shape and its peculiar orientation makes this cloud, named as the Gangotri wave, one of the largest and most intriguing structures identified in the Milky Way., 10 pages, 7 figures, accepted for publication in ApJ Letters
Published: 2021

30. 'We Have Been Part of the Response': The Effects of COVID-19 on Community and Allotment Gardens in the Global North

Author: Runrid Fox-Kämper, Lidia Poniży, Chris Blythe, Agnès Fargue-Lelièvre, Nevin Cohen, Kathrin Specht, Konstancja Fedeńczak, Victoria Schoen, Silvio Caputo, University of Kent [Canterbury], Social Farms & Gardens, ILS - Research Institute for Regional and Urban Development (ILS - Research Institute for Regional and Urban Development), ILS - Research Institute for Regional and Urban Development, Sciences pour l'Action et le Développement : Activités, Produits, Territoires (SADAPT), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), City University of New York [New York] (CUNY), Adam Mickiewicz University in Poznań (UAM), JPI Urban Europe's call SUGI—FWE Nexus, ANR-17-SUGI-0001,FEW-meter,The FEW-meter : an integrative model to measure and improve urban agriculture, shifting it towards circular urban metabolism(2017), European Project: ES/S002170/2,FEW-meter project, European Project: 01LF1801A, European Project: 18929627, European Project: 2017/25/Z/HS4/03048, and European Project: 730254
Subjects: Community cohesion, Economic growth, media_common.quotation_subject, [SDV.SA.AGRO]Life Sciences [q-bio]/Agricultural sciences/Agronomy, 010501 environmental sciences, Horticulture, Management, Monitoring, Policy and Law, 01 natural sciences, Food processing and manufacture, 03 medical and health sciences, 0302 clinical medicine, 11. Sustainability, Pandemic, allotment garden, Disinvestment, TX341-641, 030212 general & internal medicine, Urban agriculture, resilience, 0105 earth and related environmental sciences, media_common, 2. Zero hunger, Global and Planetary Change, response, Ecology, community garden, Nutrition. Foods and food supply, COVID-19, TP368-456, Allotment, Geography, Work (electrical), 13. Climate action, Psychological resilience, Agronomy and Crop Science, Nexus (standard), Food Science
Abstract: Throughout history, urban agriculture practitioners have adapted to various challenges by continuing to provide food and social benefits. Urban gardens and farms have also responded to sudden political, economic, ecological, and social crises: wartime food shortages;urban disinvestment and property abandonment;earthquakes and floods;climate-change induced weather events;and global economic disruptions. This paper examines the effects on, and responses by, urban farms and gardens to the COVID-19 pandemic. The paper is based on data collected in the summer of 2020 at the onset of the pandemic when cities were struggling with appropriate responses to curb its spread. It builds on an international research project (FEW-meter) that developed a methodology to measure material and social benefits of urban agriculture (UA) in five countries (France, Germany, Poland, UK and USA) over two growing seasons, from a Food-Energy-Water nexus perspective. We surveyed project partners to ascertain the effects of COVID-19 on those gardens and farms and we interviewed policy stakeholders in each country to investigate the wider impacts of the pandemic on UA. We report the results with respect to five key areas: (1) garden accessibility and service provision during the pandemic;(2) adjustments to operational arrangements;(3) effects on production;(4) support for urban farms and gardens through the pandemic;and (5) thoughts about the future of urban agriculture in the recovery period and beyond. The paper shows that the pandemic resulted in multiple challenges to gardens and farms including the loss of ability to provide support services, lost income, and reductions in output because of reduced labor supply. But COVID-19 also created several opportunities: new markets to sell food locally;more time available to gardeners to work in their allotments;and increased community cohesion as neighboring gardeners looked out for one another. By illustrating the range of challenges faced by the pandemic, and strategies to address challenges used by different farms and gardens, the paper illustrates how gardens in this pandemic have adapted to become more resilient and suggests lessons for pandemic recovery and longer-term planning to enable UA to respond to future public health and other crises. © Copyright © 2021 Schoen, Blythe, Caputo, Fox-Kamper, Specht, Fargue-Lelievre, Cohen, Ponizy and Fedenczak.
Published: 2021

31. On the space of connections having non-trivial twisted harmonic spinors

Author: Waterstraat, Nils [School of Mathematics, Statistics & Actuarial Science, University of Kent, Canterbury, Kent CT2 7NF (United Kingdom)]
Published: 2015
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32. Structural chemistry and magnetic properties of Y{sub 2}CoGe{sub 4}O{sub 12}

Author: Ramos, Silvia [School of Physical Sciences, Ingram Building, University of Kent, Canterbury, Kent CT2 7NH (United Kingdom)]
Published: 2015
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33. Investigating the mesostructure of ordered porous silica nanocomposites by transmission electron microscopy techniques

Author: Corrias, A. [INSTM and Department of Chemical and Geological Science, University of Cagliari, Monserrato (Canada) Italy and School of Physical Sciences, Ingram Building, University of Kent, Canterbury (United Kingdom)]
Published: 2014
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34. Conserved ancestral tropical niche but different continental histories explain the latitudinal diversity gradient in brush-footed butterflies

Author: Chris D. Jiggins, André V. L. Freitas, Chris J. Müller, Ullasa Kodandaramaiah, Fabien L. Condamine, Richard I. Vane-Wright, Carla M. Penz, Nicolas Chazot, Sören Nylin, Sean P. Mullen, Elena Ortiz-Acevedo, Akito Y. Kawahara, David J. Lohman, Carlos Peña, Anna Zubek, Andrew D. Warren, Roger Vila, Christopher W. Wheat, Karina L. Silva-Brandão, Kwaku Aduse-Poku, Pável Matos-Maraví, Marianne Elias, Niklas Wahlberg, Gytis Dudas, Zdenek Fric, Irena Kleckova, Phil DeVries, Gerardo Lamas, Condamine, Fabien L [0000-0003-1673-9910], Kodandaramaiah, Ullasa [0000-0002-1564-1738], Matos-Maraví, Pável [0000-0002-2885-4919], Lohman, David J [0000-0002-0689-2906], Silva-Brandão, Karina L [0000-0002-6423-424X], Zubek, Anna [0000-0003-3663-522X], Vila, Roger [0000-0002-2447-4388], Jiggins, Chris D [0000-0002-7809-062X], Freitas, Andre V L [0000-0002-5763-4990], Wahlberg, Niklas [0000-0002-1259-3363], Apollo - University of Cambridge Repository, Agence Nationale de la Recherche (France), National Geographic Society, Sigma Xi, Czech Science Foundation, Agencia Estatal de Investigación (España), Generalitat de Catalunya, Swedish Research Council, Lund University, Institut de Systématique, Evolution, Biodiversité (ISYEB ), Muséum national d'Histoire naturelle (MNHN)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA), Institut des Sciences de l'Evolution de Montpellier (UMR ISEM), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS), Fred Hutchinson Cancer Research Center [Seattle] (FHCRC), Universidad Nacional Mayor de San Marcos (UNMSM), Indian Institute of Science Education and Research Thiruvananthapuram (IISER TVM), Department of Biological and Environmental Sciences [Gothenburg], University of Gothenburg (GU), Georgia State University, University System of Georgia (USG), Florida Museum of Natural History [Gainesville], University of Florida [Gainesville] (UF), City University of New York [New York] (CUNY), University of New Orleans, Institute of Entomology [České Budějovice] (BIOLOGY CENTRE CAS), Biology Centre of the Czech Academy of Sciences (BIOLOGY CENTRE CAS), Czech Academy of Sciences [Prague] (CAS)-Czech Academy of Sciences [Prague] (CAS), Stockholm University, Australian Museum [Sydney], Universidade Estadual de Campinas = University of Campinas (UNICAMP), Uniwersytet Jagielloński w Krakowie = Jagiellonian University (UJ), Institut de Biologia Evolutiva [Barcelona] (IBE / UPF - CSIC), Universitat Pompeu Fabra [Barcelona] (UPF), The Natural History Museum [London] (NHM), University of Kent [Canterbury], Boston University [Boston] (BU), University of Cambridge [UK] (CAM), Lund University [Lund], ANR-10-LABX-0025,CEBA,CEnter of the study of Biodiversity in Amazonia(2010), ANR-16-CE02-0012,CLEARWING,La transparence : origine physique, fonctions adaptatives et évolution chez les papillons transparents(2016), Muséum national d'Histoire naturelle (MNHN)-École pratique des hautes études (EPHE), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Centre National de la Recherche Scientifique (CNRS)-Institut de recherche pour le développement [IRD] : UR226, Universidade Estadual de Campinas (UNICAMP), University of Campinas [Campinas] (UNICAMP), Condamine, Fabien L. [0000-0003-1673-9910], Lohman, David J. [0000-0002-0689-2906], Silva-Brandão, Karina L. [0000-0002-6423-424X], Jiggins, Chris D. [0000-0002-7809-062X], Freitas, Andre V. L. [0000-0002-5763-4990], and Freitas, Andre VL [0000-0002-5763-4990]
Subjects: 0106 biological sciences, Genetic Speciation, Science, Biogeography, Biodiversity, General Physics and Astronomy, Genes, Insect, [SDV.BID]Life Sciences [q-bio]/Biodiversity, Extinction, Biological, 010603 evolutionary biology, 01 natural sciences, Nymphalidae, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, Spatio-Temporal Analysis, Animals, 631/181/757, 14. Life underwater, Macroecology, Phylogeny, 030304 developmental biology, 0303 health sciences, Tropical Climate, Multidisciplinary, Extinction, biology, Ecology, Geography, General Chemistry, 15. Life on land, biology.organism_classification, Phylogenetics, 631/158/852, 631/158/851, 704/158/670, Biological dispersal, Species richness, Animal Distribution, Butterflies, 631/158/670
Abstract: The global increase in species richness toward the tropics across continents and taxonomic groups, referred to as the latitudinal diversity gradient, stimulated the formulation of many hypotheses to explain the underlying mechanisms of this pattern. We evaluate several of these hypotheses to explain spatial diversity patterns in a butterfly family, the Nymphalidae, by assessing the contributions of speciation, extinction, and dispersal, and also the extent to which these processes differ among regions at the same latitude. We generate a time-calibrated phylogeny containing 2,866 nymphalid species (~45% of extant diversity). Neither speciation nor extinction rate variations consistently explain the latitudinal diversity gradient among regions because temporal diversification dynamics differ greatly across longitude. The Neotropical diversity results from low extinction rates, not high speciation rates, and biotic interchanges with other regions are rare. Southeast Asia is also characterized by a low speciation rate but, unlike the Neotropics, is the main source of dispersal events through time. Our results suggest that global climate change throughout the Cenozoic, combined with tropical niche conservatism, played a major role in generating the modern latitudinal diversity gradient of nymphalid butterflies., F.L.C is supported by an “Investissements d’Avenir” grant managed by the Agence Nationale de la Recherche (CEBA, ref. ANR-10-LABX-25-01). D.J.L. was supported by grants DEB-1541557 from NSF and WW-227R-17 from the National Geographic Society. R.I.V.W. was supported by Leverhulme Trust emeritus programme. M.E. was supported by an ATIP grant, a grant from the Human Frontier Science Program (RGP0014/2016) and a grant from the French National Research Agency (ANR CLEARWING ANR-16-CE02-0012). E.O.A. was supported by Sigma-Xi (G20100315153261), Center for Systematic Entomology and the Council of the Linnean Society and the Systematics Association for the Systematics Research Fund. S.N. was supported by the Swedish Research Council (2015-04218 and 2019-03441). P.M.M. was supported by a Czech Science Foundation grant (Junior GAČR, 20-18566Y). R.V. was supported by projects PID2019-107078GB-I00 / AEI / 10.13039/501100011033 (Agencia Estatal de Investigación) and 2017-SGR-991 (Generalitat de Catalunya). N.W. acknowledges support by the Swedish Research Council (2015-04441) and a start-up grant from the Department of Biology, Lund University.
Published: 2021

35. A prenylated dsRNA sensor protects against severe COVID-19

Author: Wickenhagen, A, Sugrue, E, Lytras, S, Kuchi, S, Noerenberg, M, Turnbull, ML, Loney, C, Herder, V, Allan, J, Jarmson, I, Cameron-Ruiz, N, Varjak, M, Pinto, RM, Lee, JY, Iselin, L, Palmalux, N, Stewart, DG, Swingler, S, Greenwood, EJD, Crozier, TWM, Gu, Q, Davies, EL, Clohisey, S, Wang, B, Trindade Maranhão Costa, F, Freire Santana, M, de Lima Ferreira, LC, Murphy, L, Fawkes, A, Meynert, A, Grimes, G, Da Silva Filho, JL, Marti, M, Hughes, J, Stanton, RJ, Wang, ECY, Ho, A, Davis, I, Jarrett, RF, Castello, A, Robertson, DL, Semple, MG, Openshaw, PJM, Palmarini, M, Lehner, PJ, Baillie, JK, Rihn, SJ, Wilson, SJ, ISARIC4C Investigators, Carson, G, Alex, B, Bach, B, Barclay, WS, Bogaert, D, Chand, M, Cooke, GS, Docherty, AB, Dunning, J, da Silva Filipe, A, Fletcher, T, Green, CA, Harrison, EM, Ho, AYW, Horby, PW, Ijaz, S, Khoo, S, Klenerman, P, Law, A, Lim, WS, Mentzer, AJ, Merson, L, Meynert, AM, Noursadeghi, M, Moore, SC, Paxton, WA, Pollakis, G, Price, N, Rambaut, A, Russell, CD, Sancho-Shimizu, V, Scott, JT, de Silva, T, Sigfrid, L, Solomon, T, Sriskandan, S, Stuart, D, Summers, C, Tedder, RS, Thomson, EC, Thompson, AAR, Thwaites, RS, Turtle, LCW, Gupta, RK, Palmieri, C, Swann, OV, Zambon, M, Dumas, M-E, Griffin, JL, Takats, Z, Chechi, K, Andrikopoulos, P, Osagie, A, Olanipekun, M, Liggi, S, Lewis, MR, Dos Santos Correia, G, Sands, CJ, Takis, P, Maslen, L, Hardwick, H, Donohue, C, Griffiths, F, Oosthuyzen, W, Donegan, C, Spencer, RG, Norman, L, Pius, R, Drake, TM, Fairfield, CJ, Knight, SR, Mclean, KA, Murphy, D, Shaw, CA, Dalton, J, Girvan, M, Saviciute, E, Roberts, S, Harrison, J, Marsh, L, Connor, M, Halpin, S, Jackson, C, Gamble, C, Plotkin, D, Lee, J, Leeming, G, Wham, M, Hendry, R, Scott-Brown, J, Greenhalf, W, Shaw, V, McDonald, SE, Keating, S, Ahmed, KA, Armstrong, JA, Ashworth, M, Asiimwe, IG, Bakshi, S, Barlow, SL, Booth, L, Brennan, B, Bullock, K, Catterall, BWA, Clark, JJ, Clarke, EA, Cole, S, Cooper, L, Cox, H, Davis, C, Dincarslan, O, Dunn, C, Dyer, P, Elliott, A, Evans, A, Finch, L, Fisher, LWS, Foster, T, Garcia-Dorival, I, Gunning, P, Hartley, C, Jensen, RL, Jones, CB, Jones, TR, Khandaker, S, King, K, Kiy, RT, Koukorava, C, Lake, A, Lant, S, Latawiec, D, Lavelle-Langham, L, Lefteri, D, Lett, L, Livoti, LA, Mancini, M, McDonald, S, McEvoy, L, McLauchlan, J, Metelmann, S, Miah, NS, Middleton, J, Mitchell, J, Murphy, EG, Penrice-Randal, R, Pilgrim, J, Prince, T, Reynolds, W, Ridley, PM, Sales, D, Shaw, VE, Shears, RK, Small, B, Subramaniam, KS, Szemiel, A, Taggart, A, Tanianis-Hughes, J, Thomas, J, Trochu, E, van Tonder, L, Wilcock, E, Zhang, JE, Flaherty, L, Maziere, N, Cass, E, Carracedo, AD, Carlucci, N, Holmes, A, Massey, H, Wrobel, N, McCafferty, S, Morrice, K, MacLean, A, Adeniji, K, Agranoff, D, Agwuh, K, Ail, D, Aldera, EL, Alegria, A, Allen, S, Angus, B, Ashish, A, Atkinson, D, Bari, S, Barlow, G, Barnass, S, Barrett, N, Bassford, C, Basude, S, Baxter, D, Beadsworth, M, Bernatoniene, J, Berridge, J, Berry, C, Best, N, Bothma, P, Chadwick, D, Brittain-Long, R, Bulteel, N, Burden, T, Burtenshaw, A, Caruth, V, Chambler, D, Chee, N, Child, J, Chukkambotla, S, Clark, T, Collini, P, Cosgrove, C, Cupitt, J, Cutino-Moguel, M-T, Dark, P, Dawson, C, Dervisevic, S, Donnison, P, Douthwaite, S, Drummond, A, DuRand, I, Dushianthan, A, Dyer, T, Evans, C, Eziefula, C, Fegan, C, Finn, A, Fullerton, D, Garg, S, Garg, A, Gkrania-Klotsas, E, Godden, J, Goldsmith, A, Graham, C, Hardy, E, Hartshorn, S, Harvey, D, Havalda, P, Hawcutt, DB, Hobrok, M, Hodgson, L, Hormis, A, Jacobs, M, Jain, S, Jennings, P, Kaliappan, A, Kasipandian, V, Kegg, S, Kelsey, M, Kendall, J, Kerrison, C, Kerslake, I, Koch, O, Koduri, G, Koshy, G, Laha, S, Laird, S, Larkin, S, Leiner, T, Lillie, P, Limb, J, Linnett, V, Little, J, Lyttle, M, MacMahon, M, MacNaughton, E, Mankregod, R, Masson, H, Matovu, E, McCullough, K, McEwen, R, Meda, M, Mills, G, Minton, J, Mirfenderesky, M, Mohandas, K, Mok, Q, Moon, J, Moore, E, Morgan, P, Morris, C, Mortimore, K, Moses, S, Mpenge, M, Mulla, R, Murphy, M, Nagel, M, Nagarajan, T, Nelson, M, Norris, L, O'Shea, MK, Otahal, I, Ostermann, M, Pais, M, Panchatsharam, S, Papakonstantinou, D, Paraiso, H, Patel, B, Pattison, N, Pepperell, J, Peters, M, Phull, M, Pintus, S, Singh Pooni, J, Planche, T, Post, F, Price, D, Prout, R, Rae, N, Reschreiter, H, Reynolds, T, Richardson, N, Roberts, M, Roberts, D, Rose, A, Rousseau, G, Ruge, B, Ryan, B, Saluja, T, Schmid, ML, Shah, A, Shanmuga, P, Sharma, A, Shawcross, A, Sizer, J, Shankar-Hari, M, Smith, R, Snelson, C, Spittle, N, Staines, N, Stambach, T, Stewart, R, Subudhi, P, Szakmany, T, Tatham, K, Thompson, C, Thompson, R, Tridente, A, Tupper-Carey, D, Twagira, M, Vallotton, N, Vancheeswaran, R, Vincent-Smith, L, Visuvanathan, S, Vuylsteke, A, Waddy, S, Wake, R, Walden, A, Welters, I, Whitehouse, T, Whittaker, P, Whittington, A, Papineni, P, Wijesinghe, M, Williams, M, Wilson, L, Winchester, S, Wiselka, M, Wolverson, A, Wootton, DG, Workman, A, Yates, B, Young, P, Division of Computational and Systems Medicine, Imperial College London, London, SW7 2AZ, UK, Imperial College London - National Heart and Lung Institute, Centre National de la Recherche Scientifique (CNRS), MRC - University of Glasgow Centre for Virus Research, University of Kent [Canterbury], University of Glasgow, National Institute for Health Research, UK Research and Innovation, UKRI MRC COVID-19 Rapid Response Call, Mentzer, AJ, Investigators, ISARIC4C, Lee, J, and Angus, B
Subjects: 2',5'-Oligoadenylate Synthetase/genetics, L PATHWAY, viruses, SINGLE-NUCLEOTIDE POLYMORPHISM, RNASE-L, RNA, Viral/chemistry, RNA, Double-Stranded/chemistry, Virus Replication, Severity of Illness Index, COVID-19/enzymology, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Chiroptera, Sense (molecular biology), 2',5'-Oligoadenylate Synthetase, MESH: COVID-19, MESH: Animals, MESH: Interferons, ENZYME-ACTIVITY, MESH: 2',5'-Oligoadenylate Synthetase, Endoribonucleases/metabolism, 0303 health sciences, MESH: Protein Prenylation, Multidisciplinary, I INTERFERON, Coronaviridae/enzymology, MESH: Polymorphism, Single Nucleotide, 030302 biochemistry & molecular biology, MESH: Chiroptera, CORONAVIRUS REPLICATION, 3. Good health, Cell biology, Multidisciplinary Sciences, Isoenzymes, RNA silencing, VIRUS NS1 PROTEIN, MESH: RNA, Viral, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, MESH: Isoenzymes, Science & Technology - Other Topics, RNA, Viral, MESH: 5' Untranslated Regions, [SDV.IMM]Life Sciences [q-bio]/Immunology, SARS-CORONAVIRUS, Gene isoform, MESH: Endoribonucleases, Retroelements, RNase P, Coronaviridae, General Science & Technology, Protein Prenylation, Biology, Polymorphism, Single Nucleotide, Chiroptera/genetics, 03 medical and health sciences, MESH: RNA, Double-Stranded, MESH: Retroelements, SARS-CoV-2/genetics, MESH: Severity of Illness Index, Endoribonucleases, Animals, Humans, MESH: SARS-CoV-2, Interferons/immunology, Gene, ISARIC4C Investigators, 030304 developmental biology, RNA, Double-Stranded, Science & Technology, MESH: Humans, ACCEPTOR SITE, Phosphoric Diester Hydrolases, SARS-CoV-2, fungi, MESH: Virus Replication, RNA, COVID-19, Phosphoric Diester Hydrolases/genetics, Viral replication, A549 Cells, Protein prenylation, SPLICE-SITE POLYMORPHISM, Interferons, MESH: A549 Cells, 5' Untranslated Regions, MESH: Phosphoric Diester Hydrolases, Isoenzymes/genetics, MESH: Coronaviridae
Abstract: International audience; INTRODUCTIONInterferons (IFNs) are cytokines that are rapidly deployed in response to invading pathogens. By initiating a signaling cascade that stimulates the expression of hundreds of genes, IFNs create an antiviral state in host cells. Because IFNs heavily influence COVID-19 outcomes, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication can be inhibited by the antiviral state, it is important to understand how the individual antiviral effectors encoded by IFN-stimulated genes (ISGs) inhibit SARS-CoV-2.RATIONALEWe hypothesized that IFN-stimulated antiviral effectors can inhibit SARS-CoV-2, and that variation at the loci encoding these defenses underlies why some people are more susceptible to severe COVID-19.RESULTSWe used arrayed ISG expression screening to reveal that 2′-5′-oligoadenylate synthetase 1 (OAS1) consistently inhibited SARS-CoV-2 in different contexts. Using CRISPR-Cas9, we found that endogenous OAS1 makes a substantial contribution to the antiviral state by recognizing short stretches of double-stranded RNA (dsRNA) and activating RNase L. We globally mapped where OAS1 binds to SARS-CoV-2 viral RNAs and found that OAS1 binding is remarkably specific, with two conserved stem loops in the SARS-CoV-2 5′-untranslated region (UTR) constituting the principal viral target.OAS1 expression was readily detectable at the sites of infection in individuals who died of COVID-19, and specific OAS1 alleles are known to be associated with altered susceptibility to infection and severe disease. It had previously been reported that alleles containing a common splice-acceptor single nucleotide polymorphism in OAS1 (Rs10774671) were associated with less severe COVID-19. We determined that people with at least one allele with a G at this position could express a prenylated form of OAS1 (p46), whereas other individuals could not. Using a series of mutants, we found that C-terminal prenylation was necessary for OAS1 to initiate a block to SARS-CoV-2. Furthermore, confocal microscopy revealed that prenylation targeted OAS1 to perinuclear structures rich in viral dsRNA, whereas non-prenylated OAS1 was diffusely localized and unable to initiate a detectable block to SARS-CoV-2 replication.The realization that prenylation is essential for OAS1-mediated sensing of SARS-CoV-2 allowed us to examine the transcriptome of infected patients and investigate whether there was a link between the expression of prenylated OAS1 and SARS-CoV-2 disease progression. Analysis of the OAS1 transcripts from 499 hospitalized COVID-19 patients revealed that expressing prenylated OAS1 was associated with protection from severe COVID-19.Because prenylated OAS1 was so important in human cases, we wanted to determine whether horseshoe bats, the likely source of SARS-CoV-2, possessed the same defense. When we examined the genomic region where the prenylation signal should reside, retrotransposition of a long terminal repeat sequence had ablated this signal, preventing the expression of prenylated anti-CoV OAS1 in these bats.CONCLUSIONC-terminal prenylation targets OAS1 to intracellular sites rich in viral dsRNA, which are likely the SARS-CoV-2 replicative organelles. Once in the right place, OAS1 binds to dsRNA structures in the SARS-CoV-2 5′-UTR and initiates a potent block to SARS-CoV-2 replication. Thus, the correct targeting of OAS1 and the subsequent inhibition of SARS-CoV-2 likely underpins the genetic association of alleles containing a G at Rs10774671 with reduced susceptibility to infection and severe disease in COVID-19. Moreover, the conspicuous absence of this antiviral defense in horseshoe bats potentially explains why SARS-CoV-2 is so sensitive to this defense in humans.
Published: 2021

36. Insights into the dynamic trajectories of protein filament division revealed by numerical investigation into the mathematical model of pure fragmentation

Author: Magali Tournus, Marie Doumic, Miguel Escobedo, Wei-Feng Xue, Institut de Mathématiques de Marseille (I2M), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), Universidad del Pais Vasco / Euskal Herriko Unibertsitatea [Espagne] (UPV/EHU), University of Kent [Canterbury], Modelling and Analysis for Medical and Biological Applications (MAMBA), Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire Jacques-Louis Lions (LJLL (UMR_7598)), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), M.E. is supported by DGES Grant MTM2014-52347-C2-1-R and Basque Government Grant IT641-13.M. D. and M.T. were supported by the ERC Starting Grant SKIPPERAD (number 306321). W.-F.X. was supported by funding from Inria, and Biotechnology and Biological Sciences Research Council (BBSRC)UK grants BB/J008001/1 and BB/S003312/1., Centre National de la Recherche Scientifique (CNRS)-École Centrale de Marseille (ECM)-Aix Marseille Université (AMU), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), and European Commission
Subjects: Kernel Functions, Amyloid Fibrils, [SDV]Life Sciences [q-bio], Biochemistry, 01 natural sciences, Time Measurement, 010104 statistics & probability, Biopolymers, QA297, Cell Cycle and Cell Division, Biology (General), QA377, Operator Theory, QA, Biological sciences, Cytoskeleton, [PHYS]Physics [physics], Measurement, Quantitative Biology::Biomolecules, Ecology, biology, Simulation and Modeling, Monomers, 010101 applied mathematics, Chemistry, Computational Theory and Mathematics, Cell Processes, Modeling and Simulation, Physical Sciences, Engineering and Technology, Research Article, Amyloid, QH301-705.5, Prions, biomedicine, Inverse problem approach, Library science, Research and Analysis Methods, polymeric protein filaments, Cellular and Molecular Neuroscience, Amyloid assembly, Long-time dynamics, Genetics, 0101 mathematics, pure fragmentation, Molecular Biology, Ecology, Evolution, Behavior and Systematics, Numerical experiments, breakage, Fragmentation Models, Biology and Life Sciences, Proteins, Cell Biology, Models, Theoretical, stability, Polymer Chemistry, Probability Theory, Probability Distribution, Self-similar behaviour, Research council, Amyloid Proteins, Mathematics
Abstract: The dynamics by which polymeric protein filaments divide in the presence of negligible growth, for example due to the depletion of free monomeric precursors, can be described by the universal mathematical equations of ‘pure fragmentation’. The rates of fragmentation reactions reflect the stability of the protein filaments towards breakage, which is of importance in biology and biomedicine for instance in governing the creation of amyloid seeds and the propagation of prions. Here, we devised from mathematical theory inversion formulae to recover the division rates and division kernel information from time-dependent experimental measurements of filament size distribution. The numerical approach to systematically analyze the behaviour of pure fragmentation trajectories was also developed. We illustrate how these formulae can be used, provide some insights on their robustness, and show how they inform the design of experiments to measure fibril fragmentation dynamics. These advances are made possible by our central theoretical result on how the length distribution profile of the solution to the pure fragmentation equation aligns with a steady distribution profile for large times., Author summary Amyloid fibrils are fibrillar protein structures involved in many neurodegenerative illnesses, such as Parkinson’s disease or Alzheimer’s disease. To propagate in disease, these misfolded protein aggregates must grow and divide to proliferate. Therefore, the intrinsic characteristics of their division, including the division rate and the pattern of division in terms of whether the fibrils are likely to break in the middle or at the edges, impact the disease aetiology. Here, we discovered mathematical formulae that can be used to directly extract the fibril division characteristics from recent experiments data obtained from time-dependent fibril length distribution measurements. We explain how these formulae can be used, and prove the robustness of the division rate formula where small errors in the measurement leads to small errors in the division rate. We also demonstrate that the mathematical formula is not robust enough to precisely decipher the pattern of division in the data, and suggest instead new future experimental design with short time measurements in experiments starting with fibril suspensions where all fibrils have similar size, which would be suitable to provide improved estimates.
Published: 2021

37. Get a grip: Variation in human hand grip strength and implications for human evolution

Author: Gillian S. Forrester, Trudi Edginton, Haiko Ballieux, Cosmin Stamate, Katie Town, Ameline Bardo, Georgina Donati, Tracy L. Kivell, School of Anthropology and Conservation [University of Kent], University of Kent [Canterbury], University of Oxford [Oxford], University of Westminster [London] (UOW), Birkbeck College [University of London], and University of London [London]
Subjects: medicine.medical_specialty, Physics and Astronomy (miscellaneous), General Mathematics, [SHS.ANTHRO-BIO]Humanities and Social Sciences/Biological anthropology, BF, BH, HM, psyc, 03 medical and health sciences, Grip strength, 0302 clinical medicine, Physical medicine and rehabilitation, human evolution, Form and function, Computer Science (miscellaneous), medicine, QA1-939, 0601 history and archaeology, Bipedalism, functional morphology, 060101 anthropology, Hand function, [SPI.MECA.BIOM]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph], hand shape, 06 humanities and the arts, manual activities, Hand dominance, Variation (linguistics), Human evolution, Chemistry (miscellaneous), GN, Laterality, hand dominance, power grip strength, Psychology, directional asymmetry, 030217 neurology & neurosurgery, Mathematics
Abstract: Although hand grip strength is critical to the daily lives of humans and our arboreal great ape relatives, the human hand has changed in form and function throughout our evolution due to terrestrial bipedalism, tool use, and directional asymmetry (DA) such as handedness. Here we investigate how hand form and function interact in modern humans to gain an insight into our evolutionary past. We measured grip strength in a heterogeneous, cross-sectional sample of human participants (n = 662, 17 to 83 years old) to test the potential effects of age, sex, asymmetry (hand dominance and handedness), hand shape, occupation, and practice of sports and musical instruments that involve the hand(s). We found a significant effect of sex and hand dominance on grip strength, but not of handedness, while hand shape and age had a greater influence on female grip strength. Females were significantly weaker with age, but grip strength in females with large hands was less affected than those with long hands. Frequent engagement in hand sports significantly increased grip strength in the non-dominant hand in both sexes, while only males showed a significant effect of occupation, indicating different patterns of hand dominance asymmetries and hand function. These results improve our understanding of the link between form and function in both hands and offer an insight into the evolution of human laterality and dexterity.
Published: 2021

38. Linear Exponentials as Graded Modal Types

Author: Jack Hughes, Daniel Marshall, James Wood, Dominic Orchard, University of Kent [Canterbury], and University of Strathclyde [Glasgow]
Subjects: Mathematics::Commutative Algebra, Computer Science::Logic in Computer Science, Mathematics::Rings and Algebras, [INFO.INFO-LO]Computer Science [cs]/Logic in Computer Science [cs.LO]
Abstract: International audience; Graded type systems, which allow resource usage in programs to be tracked and reasoned about, are proliferating in recent works. These systems generalise ideas from Bounded Linear Logic (BLL), which allows the exponential modality ! from linear logic to be indexed by a bound on the number of times a formula is used. Graded systems generalise BLL's indexed modality to an arbitrary semiring of grades. Despite their relation to linear logic, particular choices in most graded type systems mean they cannot faithfully model ! due to the interaction between ! and ⊗; there are certain distributive laws that can be derived in graded type systems but cannot be derived in linear logic. We remedy this by enriching the structure of the grading with an additional operation, and show how this recovers the expressive power of Intuitionistic Multiplicative Exponential Linear Logic (IMELL) in a system with graded modal types. We briefly discuss our implementation involving this new operation for the graded modal language Granule.
Published: 2021

39. RootAsRole: Towards a Secure Alternative to sudo/su Commands for Home Users and SME Administrators

Author: Rémi Venant, Romain Laborde, David W. Chadwick, Abdelmalek Benzekri, Ahmad Samer Wazan, Zayed University, Service IntEgration and netwoRk Administration (IRIT-SIERA), Institut de recherche en informatique de Toulouse (IRIT), Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT)-Université de Toulouse (UT)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Toulouse Mind & Brain Institut (TMBI), Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT), University of Kent [Canterbury], Le Mans Université (UM), IFIP : International Federation for Information Processing, Audun Jøsang, Lynn Futcher, Janne Hagen, TC 11, European Project: 830929,CyberSec4Europe, Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse 1 Capitole (UT1), and Université Fédérale Toulouse Midi-Pyrénées
Subjects: Software_OPERATINGSYSTEMS, Computer science, Control (management), Principle of least privilege, sudo/su commands, Access control, 02 engineering and technology, Computer security, computer.software_genre, Task (project management), Set (abstract data type), [INFO.INFO-CR]Computer Science [cs]/Cryptography and Security [cs.CR], [INFO.INFO-NI]Computer Science [cs]/Networking and Internet Architecture [cs.NI], 020204 information systems, Privilege escalation, 0202 electrical engineering, electronic engineering, information engineering, Role-based access control, [INFO]Computer Science [cs], Linux capabilities, business.industry, Context (computing), 020207 software engineering, business, computer
Abstract: Part 4: Application and System Security; International audience; The typical way to run an administrative task on Linux is to execute it in the context of a super user. This breaks the principle of least privilege on access control. Other solutions, such as SELinux and AppArmor, are available but complex to use. In this paper, a new Linux module, named RootAsRole, is proposed to allow users to fine-grained control the privileges they grant to Linux commands as capabilities. It adopts a role-based access control (RBAC) [14], in which administrators can define a set of roles and the capabilities that are assigned to them. Administrators can then define the rules controlling what roles users or groups can assign to themselves. Each time a Linux user wants to execute a program that necessitates one or more capabilities, (s)he should assign the role to him/herself that contains the needed capabilities, providing there is a rule that allows it. A pilot implementation on Linux systems is illustrated in detail.
Published: 2021

40. Defining the indigenous ranges of species to account for geographic and taxonomic variation in the history of human impacts: reply to Sanderson 2019

Author: Erik Meijaard, Thomas M. Brooks, Jon Paul Rodríguez, Ana S. L. Rodrigues, P. J. Stephenson, Molly K. Grace, Barney Long, Craig Hilton-Taylor, H. Resit Akçakaya, Richard P. Young, David Mallon, IUCN Species Survival Commission (IUCN SSC), Department of Zoology [Oxford], University of Oxford [Oxford], Department of Ecology and Evolution, Stony Brook University [SUNY] (SBU), State University of New York (SUNY)-State University of New York (SUNY), Centre d’Ecologie Fonctionnelle et Evolutive (CEFE), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut National de la Recherche Agronomique (INRA)-Université Paul-Valéry - Montpellier 3 (UPVM)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut de Recherche pour le Développement (IRD [France-Sud]), Global Wildlife Conservation (GWC), Division of Biology and Conservation Ecology, Manchester Metropolitan University (MMU), Durrell Institute of Conservation and Ecology, University of Kent [Canterbury], Durrell Wildlife Conservation Trust, International Union for Conservation of Nature (IUCN), Red List Unit, Université Paul-Valéry - Montpellier 3 (UM3)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-École pratique des hautes études (EPHE)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), University of Oxford, Université Paul-Valéry - Montpellier 3 (UPVM)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-École Pratique des Hautes Études (EPHE), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)
Subjects: 0106 biological sciences, Conservation of Natural Resources, Ecology, Range (biology), 010604 marine biology & hydrobiology, Biodiversity, Geographic variation, [SDV.BID]Life Sciences [q-bio]/Biodiversity, 15. Life on land, 010603 evolutionary biology, 01 natural sciences, Indigenous, Geography, Variation (linguistics), Humans, IUCN Red List, Ecosystem, 14. Life underwater, Ecology, Evolution, Behavior and Systematics, Nature and Landscape Conservation
Abstract: International audience; Accounting for taxonomic and geographic variation in historic human impacts on indigenous range will facilitate use of IUCN’s Green List of Species.
Published: 2021

41. Analysis of diverse eukaryotes suggests the existence of an ancestral mitochondrial apparatus derived from the bacterial type II secretion system

Author: Alžběta Motyčková, Čestmír Vlček, Vladimír Klimeš, B. Franz Lang, Michael W. Gray, Zuzana Vaitová, Anastasios D. Tsaousis, Tomáš Pánek, Ingrid Guilvout, Marek Eliáš, Romain Derelle, Vojtěch Žárský, Markéta Petrů, Mohamed Chami, Karel Harant, Lenka Horváthová, Jan Pyrih, Olivera Francetic, Luboš Voleman, Pavel Doležal, Lenka Marková, Veronika Klápšťová, Ivan Čepička, Klára Hryzáková, Martina Vinopalová, Dpt of Parasitology [Prague], Charles University [Prague] (CU), Ostravská univerzita / University of Ostrava, University of Birmingham [Birmingham], University of Kent [Canterbury], Czech Academy of Sciences [Prague] (CAS), Faculty of Medicine [Brno] (MED / MUNI), Masaryk University [Brno] (MUNI), Dalhousie University [Halifax], Center for Cellular Imaging and Nanoanalytics, University of Basel (Unibas), Biochimie des Interactions Macromoléculaires / Biochemistry of Macromolecular Interactions, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Université de Montréal (UdeM), This work was supported by Czech Science Foundation grants 13-29423S to P.D. and 18-18699S to M.E., and the KONTAKT II grant LH15253 provided by Ministry of Education, Youth and Sports of CR (MEYS) to P.D., This work was also supported by MEYS within the National Sustainability Program II (Project BIOCEV-FAR, LQ1604) the project BIOCEV (CZ.1.05/1.1.00/02.0109), and the project 'Centre for research of pathogenicity and virulence of parasites' (No. CZ.02.1.01/0.0/0.0/16_019/0000759) funded by European Regional Development Fund (ERDF) and MEYS and by Moore-Simons Project on the Origin of the Eukaryotic Cell to P.D. https://doi.org/10.37807/GBMF9738, The work in the OF laboratory was funded by the ANR-14-CE09-0004 grant. J.P. was supported by a grant from the Gordon and Betty Moore Foundation to ADT. This work was supported by The Ministry of Education, Youth and Sports from the Large Infrastructures for Research, Experimental Development and Innovations project 'IT4Innovations National Supercomputing Center – LM2015070'., ANR-14-CE09-0004,FiberSpace,Pili de type IV et pseudopili: structure, dynamique, assemblage et fonction moléculaire(2014), and Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Models, Molecular, Protein family, MESH: Mitochondria, MESH: Sequence Homology, Amino Acid, Science, [SDV]Life Sciences [q-bio], Protozoan Proteins, MESH: Amino Acid Sequence, Mitochondrion, Biology, MESH: Naegleria, Models, Biological, Article, Evolutionary genetics, Evolution, Molecular, Mitochondrial Proteins, Gram-Negative Bacteria, Type II Secretion Systems, parasitic diseases, MESH: Gram-Negative Bacteria, Peroxisomes, Secretion, Amino Acid Sequence, MESH: Phylogeny, MESH: Protozoan Proteins, Conserved Sequence, Phylogeny, MESH: Evolution, Molecular, Sequence (medicine), Genetics, MESH: Type II Secretion Systems, Protein translocation, MESH: Conserved Sequence, Sequence Homology, Amino Acid, Phylogenetic tree, Type II secretion system, fungi, MESH: Models, Biological, Eukaryota, MESH: Mitochondrial Proteins, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, Naegleria, Peroxisome, MESH: Peroxisomes, Mitochondria, MESH: Eukaryota, Bacterial outer membrane, MESH: Models, Molecular
Abstract: The type 2 secretion system (T2SS) is present in some Gram-negative eubacteria and used to secrete proteins across the outer membrane. Here we report that certain representative heteroloboseans, jakobids, malawimonads and hemimastigotes unexpectedly possess homologues of core T2SS components. We show that at least some of them are present in mitochondria, and their behaviour in biochemical assays is consistent with the presence of a mitochondrial T2SS-derived system (miT2SS). We additionally identified 23 protein families co-occurring with miT2SS in eukaryotes. Seven of these proteins could be directly linked to the core miT2SS by functional data and/or sequence features, whereas others may represent different parts of a broader functional pathway, possibly also involving the peroxisome. Its distribution in eukaryotes and phylogenetic evidence together indicate that the miT2SS-centred pathway is an ancestral eukaryotic trait. Our findings thus have direct implications for the functional properties of the early mitochondrion., Bacteria use the type 2 secretion system to secrete enzymes and toxins across the outer membrane to the environment. Here the authors analyse the T2SS pathway in three protist lineages and suggest that the early mitochondrion may have been capable of secreting proteins into the cytosol.
Published: 2021

42. Physical and chemical structure of high-mass star-forming regions

Author: Gieser, C, Beuther, H, Semenov, D, Ahmadi, A, Suri, S, Möller, T, Beltrán, MT, Klaassen, P, Zhang, Q, Urquhart, JS, Henning, T, Feng, S, Galván-Madrid, R, de Souza Magalhães, V, Moscadelli, L, Longmore, S, Leurini, S, Kuiper, R, Peters, T, Menten, KM, Csengeri, T, Fuller, G, Wyrowski, F, Lumsden, S, Sánchez-Monge, Á, Maud, L, Linz, H, Palau, A, Schilke, P, Pety, J, Pudritz, R, Winters, JM, Piétu, V, Max-Planck-Institut für Astronomie (MPIA), Max-Planck-Gesellschaft, Ludwig-Maximilians-Universität München (LMU), Leiden University, Universität zu Köln, INAF - Osservatorio Astrofisico di Arcetri (OAA), Istituto Nazionale di Astrofisica (INAF), Royal Observatory Edinburgh (ROE), University of Edinburgh, Harvard-Smithsonian Center for Astrophysics (CfA), Harvard University [Cambridge]-Smithsonian Institution, Centre for Astrophysics and Planetary Science [Canterbury] (CAPS), University of Kent [Canterbury], Academia Sinica Institute of Astronomy and Astrophysics (ASIAA), Academia Sinica, Chinese Academy of Sciences [Beijing] (CAS), National Astronomical Observatory of Japan (NAOJ), Universidad Nacional Autónoma de México (UNAM), Institut de RadioAstronomie Millimétrique (IRAM), Centre National de la Recherche Scientifique (CNRS), Astrophysics Research Institute [Liverpool] (ARI), Liverpool John Moores University (LJMU), INAF - Osservatorio Astronomico di Cagliari (OAC), University of Tübingen, Max-Planck-Institut für Astrophysik (MPA), Max Planck Institute for Radio Astronomy, FEMIS 2021, Laboratoire d'Astrophysique de Bordeaux [Pessac] (LAB), Université de Bordeaux (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), University of Leeds, European Southern Observatory (ESO), Instituto de Matematicas (UNAM), Laboratoire d'Etude du Rayonnement et de la Matière en Astrophysique (LERMA (UMR_8112)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-CY Cergy Paris Université (CY), and McMaster University [Hamilton, Ontario]
Subjects: [PHYS]Physics [physics], stars: formation, astrochemistry, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], ISM: molecules
Abstract: International audience; Aims. Current star formation research centers the characterization of the physical and chemical properties of massive stars, which are in the process of formation, at the spatial resolution of individual high-mass cores.Methods. We use sub-arcsecond resolution (~0.′′4) observations with the NOrthern Extended Millimeter Array at 1.37 mm to study the dust emission and molecular gas of 18 high-mass star-forming regions. With distances in the range of 0.7−5.5 kpc, this corresponds to spatial scales down to 300−2300 au that are resolved by our observations. We combined the derived physical and chemical properties of individual cores in these regions to estimate their ages. The temperature structures of these regions are determined by fitting the H2CO and CH3CN line emission. The density profiles are inferred from the 1.37 mm continuum visibilities. The column densities of 11 different species are determined by fitting the emission lines with XCLASS.Results. Within the 18 observed regions, we identified 22 individual cores with associated 1.37 mm continuum emission and with a radially decreasing temperature profile. We find an average temperature power-law index of q = 0.4 ± 0.1 and an average density power-law index of p = 2.0 ± 0.2 on scales that are on the order of several 1000 au. Comparing these results with values of p derived from the literature presumes that the density profiles remain unchanged from clump to core scales. The column densities relative to N(C18O) between pairs of dense gas tracers show tight correlations. We applied the physical-chemical model MUlti Stage ChemicaL codE to the derived column densities of each core and find a mean chemical age of ~60 000 yr and an age spread of 20 000−100 000 yr. With this paper, we release all data products of the CORE project.Conclusions. The CORE sample reveals well-constrained density and temperature power-law distributions. Furthermore, we characterized a large variety in molecular richness that can be explained by an age spread that is then confirmed by our physical-chemical modeling. The hot molecular cores show the greatest number of emission lines, but we also find evolved cores at an evolutionary stage in which most molecules are destroyed and, thus, the spectra appear line-poor once again.
Published: 2021

43. An international outbreak of Salmonella enterica serotype Enteritidis linked to eggs from Poland: a microbiological and epidemiological study

Author: Roan Pijnacker, Timothy J Dallman, Aloys S L Tijsma, Gillian Hawkins, Lesley Larkin, Saara M Kotila, Giusi Amore, Ettore Amato, Pamina M Suzuki, Sarah Denayer, Sofieke Klamer, Judit Pászti, Jacquelyn McCormick, Hassan Hartman, Gareth J Hughes, Lin C T Brandal, Derek Brown, Joël Mossong, Cecilia Jernberg, Luise Müller, Daniel Palm, Ettore Severi, Joannna Gołębiowska, Blaženka Hunjak, Slawomir Owczarek, Simon Le Hello, Patricia Garvey, Kirsten Mooijman, Ingrid H M Friesema, Coen van der Weijden, Menno van der Voort, Valentina Rizzi, Eelco Franz, Sophie Bertrand, Martine Brennan, Lynda Browning, Ryan Bruce, Vera Cantaert, Marie Chattaway, John Coia, Sarah Couper, Tjaša Žohar Čretnik, Ondřej Daniel, Anna Maria Dionisi, Laetitia Fabre, Ife Fitz-James, Karolina Florek, Martina Florianová, Eithne Fox, Tatjana Frelih, Eva Grilc, Vera Katalinic Jankovic, Nathalie Jourdan, Renata Karpíšková, Hans van den Kerkhof, Sjoerd Kuiling, Sanja Kurečić Filipović, Valeska Laisnez, Heidi Lange, Niall deLappes, Judith Leblanc, Ida Luzzi, Georgia Mandilara, Henry Mather, Wesley Mattheus, Kassiani Mellou, Deborah Morgan, Elizabeth de Pinna, Catherine Ragimbeau, Margrethe Hovda Røed, Saara Salmenlinna, Robert Smith, Alison Smith-Palmer, Michaela Špačková, Mia Torpdahl, Marija Trkov, Linda Trönnberg, Myrsini Tzani, Lara Utsi, Dariusz Wasyl, Pierre Weicherding, Graduate School, AII - Infectious diseases, National Institute for Public Health and the Environment [Bilthoven] (RIVM), Public Health England [London], Netherlands Food and Consumer Product Safety Authority (NVWA), Health Protection Scotland, European Centre for Disease Prevention and Control [Stockholm, Sweden] (ECDC), European Food Safety Authority (EFSA), European Commission [Brussels], Sciensano [Bruxelles], Réseau International des Instituts Pasteur (RIIP), National Centre for Epidemiology (NCE), Norwegian Institute of Public Health [Oslo] (NIPH), NHS Greater Glasgow and Clyde, Laboratoire National de Santé [Luxembourg] (LNS), Public Health Agency of Sweden, Statens Serum Institut [Copenhagen], Independent Author, Croatian Institute of Public Health [Zagreb] (CIPH), Istituto Superiore di Sanità (ISS), Institut Pasteur [Paris] (IP), Health Protection Surveillance Centre (HPSC), UMR 212 EME 'écosystèmes marins exploités' (EME), Institut de Recherche pour le Développement (IRD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de Montpellier (UM), School of Chemistry [Southampton, UK], University of Southampton, Department of Infectious, Centre National de Référence - National Reference Center Escherichia coli, Shigella et Salmonella (CNR-ESS), Institut de Veille Sanitaire (INVS), Stobhill Hospital, Durrell Institute of Conservation and Ecology, University of Kent [Canterbury], Department of Microbiology, National Veterinary Research Institute [Pulawy, Pologne] (NVRI), This study received funding from the European Centre for Disease Prevention and Control, the Directorate General for Health and Food Safety of the European Commission, and the following national public health and food safety institutes: the National Institute for Public Health and the Environment (Netherlands), Public Health England, Health Protection Scotland, the National Institute for Public Health (Sciensano, Belgium), National Centre for Epidemiology (Hungary), the Norwegian Institute for Public Health, the National Health Laboratory (Luxembourg), the Public Health Agency of Sweden, Statens Serum Institut (Denmark), the Croatian Institute of Public Health, Instituto Superiore di Sanità (Italy), Institut Pasteur (France), Health Protection Surveillance Centre (Ireland), the Netherlands Food and Consumer Product Safety Authority, the Chief Veterinary Inspectorate (Poland), the Scottish Salmonella, Shigella, and Clostridium difficile Reference Laboratory, and the European Union Reference Laboratory for Salmonella (Netherlands). VR and GA are employed with the European Food Safety Authority (EFSA) in its BIOCONTAM Unit that provides scientific and administrative support to EFSA's scientific activities in the area of microbiological risk assessment. PMS and EA are employed with the European Commission at the Directorate-General for Health and Food Safety. The positions and opinions presented in this Article are those of the authors alone and are not intended to represent the views or scientific works of the European Commission or EFSA., International Outbreak Investigation Team Sophie Bertrand, Martine Brennan, Lynda Browning, Ryan Bruce, Vera Cantaert, Marie Chattaway, John Coia, Sarah Couper, Tjaša Žohar Čretnik, Ondřej Daniel, Anna Maria Dionisi, Laetitia Fabre, Sanja Kurečić Filipović, Ife Fitz-James, Karolina Florek, Martina Florianová, Eithne Fox, Tatjana Frelih, Eva Grilc, Vera Katalinic Jankovic, Nathalie Jourdan, Renata Karpíšková, Hans van den Kerkhof, Katalin Krisztalovics, Sjoerd Kuiling, Valeska Laisnez, Heidi Lange, Niall deLappes, Judith Leblanc, Ida Luzzi, Georgia Mandilara, Henry Mather, Wesley Mattheus, Kassiani Mellou, Deborah Morgan, Elizabeth de Pinna, Catherine Ragimbeau, Margrethe Hovda Røed, Saara Salmenlinna, Robert Smith, Alison Smith-Palmer, Michaela Špačková, Mia Torpdahl, Marija Trkov, Linda Trönnberg, Myrsini Tzani, Lara Utsi, Dariusz Wasyl, Pierre Weicherding., European Centre for Disease Prevention and Control (ECDC), Istituto Superiore di Sanita [Rome], Institut Pasteur [Paris], and Université de Montpellier (UM)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Institut de Recherche pour le Développement (IRD)
Subjects: Male, 0301 basic medicine, Serotype, Salmonella, medicine.medical_specialty, Eggs, Population, Serogroup, medicine.disease_cause, Disease Outbreaks, 03 medical and health sciences, 0302 clinical medicine, Environmental health, Epidemiology, medicine, Humans, Life Science, 030212 general & internal medicine, education, 2. Zero hunger, education.field_of_study, Whole Genome Sequencing, biology, business.industry, Public health, Outbreak, biology.organism_classification, Food safety, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, 3. Good health, Europe, Epidemiologic Studies, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, 030104 developmental biology, Infectious Diseases, Salmonella enteritidis, Salmonella enterica, Case-Control Studies, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Female, Salmonella Food Poisoning, Poland, business
Abstract: Summary Background Salmonella spp are a major cause of food-borne outbreaks in Europe. We investigated a large multi-country outbreak of Salmonella enterica serotype Enteritidis in the EU and European Economic Area (EEA). Methods A confirmed case was defined as a laboratory-confirmed infection with the outbreak strains of S Enteritidis based on whole-genome sequencing (WGS), occurring between May 1, 2015, and Oct 31, 2018. A probable case was defined as laboratory-confirmed infection with S Enteritidis with the multiple-locus variable-number tandem repeat analysis outbreak profile. Multi-country epidemiological, trace-back, trace-forward, and environmental investigations were done. We did a case-control study including confirmed and probable cases and controls randomly sampled from the population registry (frequency matched by age, sex, and postal code). Odds ratios (ORs) for exposure rates between cases and controls were calculated with unmatched univariable and multivariable logistic regression. Findings 18 EU and EEA countries reported 838 confirmed and 371 probable cases. 509 (42%) cases were reported in 2016, after which the number of cases steadily increased. The case-control study results showed that cases more often ate in food establishments than did controls (OR 3·4 [95% CI 1·6–7·3]), but no specific food item was identified. Recipe-based food trace-back investigations among cases who ate in food establishments identified eggs from Poland as the vehicle of infection in October, 2016. Phylogenetic analysis identified two strains of S Enteritidis in human cases that were subsequently identified in salmonella-positive eggs and primary production premises in Poland, confirming the source of the outbreak. After control measures were implemented, the number of cases decreased, but increased again in March, 2017, and the increase continued into 2018. Interpretation This outbreak highlights the public health value of multi-country sharing of epidemiological, trace-back, and microbiological data. The re-emergence of cases suggests that outbreak strains have continued to enter the food chain, although changes in strain population dynamics and fewer cases indicate that control measures had some effect. Routine use of WGS in salmonella surveillance and outbreak response promises to identify and stop outbreaks in the future. Funding European Centre for Disease Prevention and Control; Directorate General for Health and Food Safety, European Commission; and National Public Health and Food Safety Institutes of the authors' countries (see Acknowledgments for full list).
Published: 2019

44. Multidomain spectral method for the Gauss hypergeometric function

Author: Marco Fasondini, Nikola Stoilov, Christian Klein, Siegfried Crespo, Corentin Vallée, Institut de Mathématiques de Bourgogne [Dijon] (IMB), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université de Bourgogne (UB), University of Kent [Canterbury], Vision, Action et Gestion d'informations en Santé (VisAGeS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Inria Rennes – Bretagne Atlantique, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-SIGNAUX ET IMAGES NUMÉRIQUES, ROBOTIQUE (IRISA-D5), Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Université de Bretagne Sud (UBS)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National de Recherche en Informatique et en Automatique (Inria)-École normale supérieure - Rennes (ENS Rennes)-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-CentraleSupélec-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Bretagne Sud (UBS)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-École normale supérieure - Rennes (ENS Rennes)-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), université de Bourgogne, IMB, Approches analytiques, numériques et des systèmes intégrables pour les équations aux dérivées partielles dispersives nonlinéaires - - ANuI2017 - ANR-17-CE40-0035 - AAPG2017 - VALID, Université de Bourgogne (UB)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS), Institute of Mathematics (University of Kent), Neuroimagerie: méthodes et applications (Empenn), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), This work was partially supported by the PARI and FEDER programs in 2016 and 2017, by the ANR-FWF project ANuI by the isite BFC via the project NAANoD and by the Marie-Curie RISE network IPaDEGAN. M. Fasondini acknowledges financial support from the EPSRC grant EP/P026532/1., ANR-17-CE40-0035,ANuI,Approches analytiques, numériques et des systèmes intégrables pour les équations aux dérivées partielles dispersives nonlinéaires(2017), Vallée, Corentin, Empenn, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Rennes 1 (UR1), and Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique)
Subjects: Singular differential equations, Mathematics::Classical Analysis and ODEs, Riemann sphere, [MATH] Mathematics [math], 010103 numerical & computational mathematics, 01 natural sciences, symbols.namesake, FOS: Mathematics, Hypergeometric function, Mathematics - Numerical Analysis, [MATH]Mathematics [math], 0101 mathematics, QA, Mathematics, Laplace's equation, Applied Mathematics, Riemann surface, Mathematical analysis, Numerical Analysis (math.NA), [MATH.MATH-NA] Mathematics [math]/Numerical Analysis [math.NA], Hypergeometric distribution, 010101 applied mathematics, Spectral methods, Harmonic function, Ordinary differential equation, symbols, Spectral method, [MATH.MATH-NA]Mathematics [math]/Numerical Analysis [math.NA]
Abstract: International audience; We present a multidomain spectral approach for Fuchsian ordinary differential equations in the particular case of the hypergeometric equation. Our hybrid approach uses Frobenius’ method and Moebius transformations in the vicinity of each of the singular points of the hypergeometric equation, which leads to a natural decomposition of the real axis into domains. In each domain, solutions to the hypergeometric equation are constructed via the well-conditioned ultraspherical spectral method. The solutions are matched at the domain boundaries to lead to a solution which is analytic on the whole compactified real line R∪∞, except for the singular points and cuts of the Riemann surface on which the solution is defined. The solution is further extended to the whole Riemann sphere by using the same approach for ellipses enclosing the singularities. The hypergeometric equation is solved on the ellipses with the boundary data from the real axis. This solution is continued as a harmonic function to the interior of the disk by solving the Laplace equation in polar coordinates with an optimal complexity Fourier–ultraspherical spectral method. In cases where logarithms appear in the solution, a hybrid approach involving an analytical treatment of the logarithmic terms is applied. We show for several examples that machine precision can be reached for a wide class of parameters, but also discuss almost degenerate cases where this is not possible.
Published: 2019

45. Electrochemical Evaluation of Pb, Ag, and Zn Cyanamides/Carbodiimides

Author: Moulay Tahar Sougrati, Maria Alfredsson, Richard Dronskowski, Lorenzo Stievano, Xiaohui Liu, Markus Mann, Jeethu Jiju Arayamparambil, Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Advanced Lithium Energy Storage Systems - ALISTORE-ERI (ALISTORE-ERI), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institute of Inorganic Chemistry [Aachen], Rheinisch-Westfälische Technische Hochschule Aachen (RWTH), School of Physical Sciences [Canterbury], University of Kent [Canterbury], Réseau sur le stockage électrochimique de l'énergie (RS2E), Université de Picardie Jules Verne (UPJV)-Institut de Chimie du CNRS (INC)-Aix Marseille Université (AMU)-Université de Pau et des Pays de l'Adour (UPPA)-Université de Nantes (UN)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Collège de France (CdF (institution))-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-Université Grenoble Alpes (UGA)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institute of Inorganic Chemistry [Aachen] (IAC RWTH), Rheinisch-Westfälische Technische Hochschule Aachen University (RWTH), Université de Nantes (UN)-Aix Marseille Université (AMU)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Collège de France (CdF (institution))-Université de Picardie Jules Verne (UPJV)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Pau et des Pays de l'Adour (UPPA)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), and Université Grenoble Alpes (UGA)-Université Grenoble Alpes (UGA)
Subjects: Diffraction, Electrode material, Materials science, General Chemical Engineering, Inorganic chemistry, 02 engineering and technology, General Chemistry, [CHIM.MATE]Chemical Sciences/Material chemistry, 010402 general chemistry, 021001 nanoscience & nanotechnology, Electrochemistry, 01 natural sciences, 3. Good health, 0104 chemical sciences, lcsh:Chemistry, lcsh:QD1-999, ddc:660, 0210 nano-technology, Absorption (electromagnetic radiation)
Abstract: PbNCN, Ag2NCN, and ZnNCN were tested as negative\ud electrode materials for Li-ion batteries. A thorough analysis of the\ud electrochemical mechanism by X-ray diffraction and X-ray absorption\ud spectroscopy showed that, unlike transition metal carbodiimides, these\ud compounds react with lithium via a two-step reaction, starting with\ud conversion followed by alloying. The conversion reaction is highly\ud irreversible for the three compounds, whereas the reversibility of the alloying\ud reaction depends on the metal, that is, highly irreversible for PbNCN and\ud Ag2NCN which contain the cyanamide group (NC−N2−) and more\ud reversible for ZnNCN containing carbodiimide (−NCN−). In the case\ud of the more covalent, cyanamide-type PbNCN and Ag2NCN, the conversion\ud reaction occurs at a higher voltage compared to the more ionic,\ud carbodiimide-type ZnNCN, correlated with the nature of bonding in the\ud NCN group and in the phases themselves. Compared to transition metal carbodiimides, these materials show rather low\ud performance, with no improvement in capacity as it would have been expected from the combination of conversion and\ud alloying.
Published: 2019

46. Preliminary Results of Exploring the Behaviour of Phyllosilicates When Subject to Thermal Conditions Relevant to Asteroid Ryugu

Author: Hallatt, Daniel, Leroux, Hugues, Roussel, Pascal, Université de Lille, CNRS, INRA, ENSCL, Unité Matériaux et Transformations - UMR 8207 [UMET], University of Kent [Canterbury], Unité de Catalyse et Chimie du Solide - UMR 8181 [UCCS], Unité Matériaux et Transformations - UMR 8207 (UMET), Centrale Lille-Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Unité de Catalyse et Chimie du Solide - UMR 8181 (UCCS), Université d'Artois (UA)-Centrale Lille-Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), the Lunar and Planetary Institute, NASA, Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centrale Lille Institut (CLIL), and Centrale Lille Institut (CLIL)-Université d'Artois (UA)-Centrale Lille-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Lille
Subjects: Thermal Processing, [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], Asteroid, [PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci], [SDU.STU]Sciences of the Universe [physics]/Earth Sciences, Ryugu, [PHYS.PHYS.PHYS-GEO-PH]Physics [physics]/Physics [physics]/Geophysics [physics.geo-ph], [CHIM.MATE]Chemical Sciences/Material chemistry, Phyllosilicates, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract: International audience; We present early XRD and STA of serpentine under elevated temperatures and controlled atmospheres.
Published: 2021

47. Definition and use of functional analogues in planetary exploration

Author: Vinciane Debaille, Caroline Smith, Frances Westall, Joseph R. Michalski, Hajime Yano, Michel Viso, Luigi Folco, A. Hutzler, Nicolas Bost, Hilde Schroeven-Deceuninck, Jutta Zipfel, Penelope J. Wozniakiewicz, Sara S. Russell, Katherine H. Joy, Jesús Martínez-Frías, John Bridges, Ludovic Ferrière, Martin Lee, Gerhard Kminek, Michael E. Zolensky, Keyron Hickman-Lewis, Frédéric Foucher, Centre de biophysique moléculaire (CBM), Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Università degli Studi di Bologna, The Natural History Museum [London] (NHM), Lunar and Planetary Institute [Houston] (LPI), NASA, Lyndon B. Johnson Space Center ES3, Houston, Texas 77058, European Space Agency (ESA), European Space Research and Technology Centre (ESTEC), University of Manchester [Manchester], University of Pisa - Università di Pisa, University of Leicester, University of Kent [Canterbury], Instituto de Geociencias [Madrid] (IGEO), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] (UCM), Université libre de Bruxelles (ULB), Japan Aerospace Exploration Agency [Sagamihara] (JAXA), Naturhistorisches Museum -Wien, University of Glasgow, The University of Hong Kong (HKU), ESA Harwell centre, UK Space Agency, Centre National d’Études Spatiales [Paris] (CNES), Senckenberg – Leibniz Institution for Biodiversity and Earth System Research - Senckenberg Gesellschaft für Naturforschung, and Leibniz Association
Subjects: 010504 meteorology & atmospheric sciences, n Mars, Computer science, Mars, 01 natural sciences, Space missions, Space exploration, Human–computer interaction, Planetary exploration, 0103 physical sciences, Selection (linguistics), sort, 010303 astronomy & astrophysics, Astrophysique, Analogue, 0105 earth and related environmental sciences, Astronomy and Astrophysics, Timeline, Planetary exploratio, Astronomie, Object (computer science), Sciences de l'espace, Space and Planetary Science, [SDU]Sciences of the Universe [physics], Spare part, Focus (optics), Word (computer architecture)
Abstract: The practical limitations inherent to human and robotic planetary exploration necessitate the development of specific protocols and methods. This non-standard approach requires testing and validation phases in order to optimise instrumental setups and improve data interpretation; this can occur prior to, during, or even after a mission. Flight instruments, and/or their spare models, may be evaluated using relevant terrestrial materials and/or locations. These materials are called analogues: “analogue sites” for large-scale locations, and “analogue samples” for smaller-scale materials. Depending on the scientific domain, the word “analogue” may carry different meanings but is invariably used to denote objects having compositions and/or physical properties similar to specific extraterrestrial objects. However, due to the variability in composition and properties of natural materials, there are always – inevitably – some differences between the analogue and the object(s) to which it refers. In analogue studies, it is, thus, important to focus on the specific properties that need to be imitated and to consider analogue properties rather than analogue sites or samples alone. Here, we introduce the concept of “functional analogues”. We first make an overview of the different types of analogues and sort them according to their utility. We then describe how different types of functional analogues can be used throughout the timeline of space missions, from the evaluation of different methods in the definition of a mission to understanding the results acquired by probes exploring extraterrestrial bodies. Finally, logical pathways are outlined that facilitate the selection of the best-suited functional analogue(s) according to their intended use and taking into account practical limitations., SCOPUS: ar.j, info:eu-repo/semantics/published
Published: 2021

48. Effects of Nutrient Management Scenarios on Marine Food Webs: A Pan-European Assessment in Support of the Marine Strategy Framework Directive

Author: Chiara Piroddi, Ekin Akoglu, Eider Andonegi, Jacob W. Bentley, Igor Celić, Marta Coll, Donna Dimarchopoulou, René Friedland, Kim de Mutsert, Raphael Girardin, Elisa Garcia-Gorriz, Bruna Grizzetti, P.-Y. Hernvann, Johanna J. Heymans, Bärbel Müller-Karulis, Simone Libralato, Christopher P. Lynam, Diego Macias, Svetla Miladinova, Fabien Moullec, Andreas Palialexis, Ove Parn, Natalia Serpetti, Cosimo Solidoro, Jeroen Steenbeek, Adolf Stips, Maciej T. Tomczak, Morgane Travers-Trolet, Athanassios C. Tsikliras, European Commission, Agencia Estatal de Investigación (España), Natural Environment Research Council (UK), BiodivERsA, Belmont Forum, National Academies of Sciences, Engineering and Medicine (US), European Commission - Joint Research Centre [Ispra] (JRC), Institute of Marine Sciences [Erdemli-Mersin] (IMS), Middle East Technical University [Ankara] (METU), United Nations Environment Programma World Conservation Monitoring Centre, School of Anthropology and Conservation [University of Kent], University of Kent [Canterbury], National Institute of Oceanography and Applied Geophysics (OGS), Marine Sciences Institute of Andalusia, Spanish Council for Scientific Research. ICMAN (CSIC), Laboratory of Ichthyology, School of Biology, Aristotle University of Thessalonik, Department of Fisheries, Animal and Veterinary Sciences, College of the Environment and Life Sciences, University of Rhode Island, Kingston, European Commission - Joint Research Centre [Geel] (JRC), Department of Environmental Science and Policy, University of California, USA, School of Marine Science and Ocean Engineering, University of New Hampshire (UNH), Laboratoire Ressources halieutiques Manche Mer du nord, IFREMER Centre Manche Mer du Nord, (HMMN), Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER), Écologie et santé des écosystèmes (ESE), AGROCAMPUS OUEST, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Unité de recherche Sciences et Technologies Halieutiques (STH), University of California [Santa Cruz] (UCSC), University of California, European Marine Board, Baltic Sea Centre, Stockholm University, Lowestoft Laboratory, Centre for Environment, Fisheries and Aquaculture Science [Weymouth] (CEFAS), Center for Earth System Research and Sustainability (CEN), Universität Hamburg (UHH), Scottish Association for Marine Science (SAMS), Spain & Ecopath International Initiative Research Association, Institut de Ciències del Mar, Écologie et Modèles pour l'Halieutique (IFREMER EMH), Institut Français de Recherche pour l'Exploitation de la Mer - Atlantique (IFREMER Atlantique), Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER), aboratory of Ichthyology, School of Biology, Aristotle University of Thessalonik, and OpenMETU
Subjects: 0106 biological sciences, lcsh:QH1-199.5, 010504 meteorology & atmospheric sciences, Ocean Engineering, lcsh:General. Including nature conservation, geographical distribution, Aquatic Science, Oceanography, Fish stock, Policy support, 01 natural sciences, hydrological modeling, Marine Strategy Framework Directive, ecological indicators, hydrodynamic and biogeochemical modeling, Ecosystem, Marine ecosystem, 14. Life underwater, lcsh:Science, [SDU.STU.OC]Sciences of the Universe [physics]/Earth Sciences/Oceanography, 0105 earth and related environmental sciences, Water Science and Technology, Trophic level, higher trophic level modeling, Global and Planetary Change, Biomass (ecology), criteria, business.industry, 010604 marine biology & hydrobiology, Environmental resource management, Pelagic zone, policy support, Ecological indicator, 13. Climate action, [SDE]Environmental Sciences, ecological modeling, Environmental science, lcsh:Q, business
Abstract: 18 pages, 7 figures, 2 tables, supplementary material https://www.frontiersin.org/articles/10.3389/fmars.2021.596797/full#supplementary-material.-- The original contributions presented in the study are included in the article/Supplementary Material, further inquiries can be directed to the corresponding author/s, Eutrophication is one of the most important anthropogenic pressures impacting coastal seas. In Europe, several legislations and management measures have been implemented to halt nutrient overloading in marine ecosystems. This study evaluates the impact of freshwater nutrient control measures on higher trophic levels (HTL) in European marine ecosystems following descriptors and criteria as defined by the Marine Strategy Framework Directive (MSFD). We used a novel pan-European marine modeling ensemble of fourteen HTL models, covering almost all the EU seas, under two nutrient management scenarios. Results from our projections suggest that the proposed nutrient reduction measures may not have a significant impact on the structure and function of European marine ecosystems. Among the assessed criteria, the spawning stock biomass of commercially important fish stocks and the biomass of small pelagic fishes would be the most impacted, albeit with values lower than 2.5%. For the other criteria/indicators, such as species diversity and trophic level indicators, the impact was lower. The Black Sea and the North-East Atlantic were the most negatively impacted regions, while the Baltic Sea was the only region showing signs of improvement. Coastal and shelf areas were more sensitive to environmental changes than large regional and sub-regional ecosystems that also include open seas. This is the first pan-European multi-model comparison study used to assess the impacts of land-based measures on marine and coastal European ecosystems through a set of selected ecological indicators. Since anthropogenic pressures are expanding apace in the marine environment and policy makers need to use rapid and effective policy measures for fast-changing environments, this modeling framework is an essential asset in supporting and guiding EU policy needs and decisions, BM-K acknowledges funding from EU-H2020 project ClimeFish (grant agreement 677039), CL received support from the project CAMPUS funded by the Natural Environment Research Council and Defra (grant agreement NERC UK NE/RE007241/1). FM was funded by the SOMBEE project of the joint BiodivERsA and Belmont Forum call “BiodivScen 2018” (ANR-18-EBI4-0003-01). KD received support from the National Academies of Sciences Engineering and Medicine Gulf Research Program (Early Career Research Fellowship). MC acknowledges partial funding from the European Union’s Horizon 2020 Research and Innovation Programme under grant agreement no 869300 (FutureMARES project). This work acknowledges institutional support of the ‘Severo Ochoa Centre of Excellence’ accreditation (CEX2019-000928-S)
Published: 2021

49. Applying the food-energy-water nexus approach to urban agriculture: From FEW to FEWP (Food-Energy-Water-People)

Author: Runrid Fox-Kämper, Joshua P. Newell, Lidia Poniży, Silvio Caputo, Kathrin Specht, Chris Blythe, Victoria Schoen, Jason K. Hawes, Nevin Cohen, Baptiste Grard, University of Kent [Canterbury], ILS, Research Institute for Regional and Urban Development, Office Aachen, Karmeliterstrasse 6, 52064 Aachen, Germany, Ecologie fonctionnelle et écotoxicologie des agroécosystèmes (ECOSYS), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), City University of New York [New York] (CUNY), University of Michigan [Ann Arbor], University of Michigan System, Adam Mickiewicz University in Poznań (UAM), UK Research & Innovation (UKRI), Economic & Social Research Council (ESRC), Federal Ministry of Education & Research (BMBF), French National Research Agency (ANR), NSF, USA, Belmont Forum, European Commission, and ANR-17-SUGI-0001,FEW-meter,The FEW-meter : an integrative model to measure and improve urban agriculture, shifting it towards circular urban metabolism(2017)
Subjects: 0106 biological sciences, Resource efficiency, [SDV.SA.AGRO]Life Sciences [q-bio]/Agricultural sciences/Agronomy, Soil Science, 010501 environmental sciences, 010603 evolutionary biology, 01 natural sciences, Life cycle assessment, 11. Sustainability, Food/Energy/Water nexus, Urban agriculture, Life-cycle assessment, 0105 earth and related environmental sciences, Urban metabolism, 2. Zero hunger, Ecology, business.industry, Material flow analysis, Forestry, Environmental economics, Social benefits, Urban Resource flow, Food energy, Food processing, NA, business, Nexus (standard)
Abstract: Many studies examine the correlation between the use of resources such as water, energy and land, and the production of food. These nexus studies focus predominantly on large scale systems, often considering the social dimensions only in terms of access to resources and participation in the decision-making process, rather than individual attitudes and behaviours with respect to resource use. Such a concept of the nexus is relevant to urban agriculture (UA), but it requires customisation to the particular characteristics of growing food in cities, which is practiced mainly at a small scale and produces not only food but also considerable social, economic, and environmental co-benefits. To this end, this paper proposes a new concept for a UA Nexus, together with a methodology for its assessment, that explicitly includes social dimensions in addition to food, energy and water. The paper develops a new conceptual basis, introducing People, together with Food, Energy and Water, as factors of the UA Nexus. A methodological approach for its assessment is presented, aimed at measuring not only resource efficiency and food production but also motivations and health benefits, as well as the ecological awareness of urban farmers. The methodology is based on a combination of methods such as diaries of everyday UA practices, a database of UA activities, life cycle assessment (LCA), and material flow analysis to connect investigations developed at a garden scale to the city scale.
Published: 2021

50. How hot is the hot zone? Computational modelling clarifies the role of parietal and frontoparietal connectivity during anaesthetic-induced loss of consciousness

Author: Ihalainen, Riku, Gosseries, Olivia, de Steen, Frederik Van, Raimondo, Federico, Panda, Rajanikant, Bonhomme, Vincent, Marinazzo, Daniele, Bowman, Howard, Laureys, Steven, Chennu, Srivas, Gestionnaire, Hal Sorbonne Université, University of Kent [Canterbury], GIGA [Université Liège], Université de Liège, Universiteit Gent = Ghent University (UGENT), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), University of Birmingham [Birmingham], University of Cambridge [UK] (CAM), Clinical sciences, Neuroprotection & Neuromodulation, Universiteit Gent = Ghent University [Belgium] (UGENT), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], and Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Male, CORTEX, Consciousness, Cognitive Neuroscience, UNRESPONSIVENESS, [SDV]Life Sciences [q-bio], Consciousness/drug effects, Neurosciences. Biological psychiatry. Neuropsychiatry, Unconsciousness, Anesthetics/administration & dosage, anesthesia, Default Mode Network/drug effects, Anaesthesia, SYSTEMS, Parietal Lobe, Medicine and Health Sciences, Humans, Electroencephalography/drug effects, NETWORK, EEG, BRAIN, Effective connectivity, Propofol, Anesthetics, Propofol/administration & dosage, brain connectivity, Default Mode Network, Electroencephalography, Unconsciousness/chemically induced, STATE, Frontal Lobe, [SDV] Life Sciences [q-bio], Mathematics and Statistics, PROPOFOL-INDUCED LOSS, Neurology, Frontal Lobe/drug effects, young adult, Female, Neural Networks, Computer, DEFAULT MODE, Dynamic causal modelling, Parietal Lobe/drug effects, computational neuroscience, RESPONSES, RC321-571
Abstract: International audience; In recent years, specific cortical networks have been proposed to be crucial for sustaining consciousness, including the posterior hot zone and frontoparietal resting state networks (RSN). Here, we computationally evaluate the relative contributions of three RSNs - the default mode network (DMN), the salience network (SAL), and the central executive network (CEN) - to consciousness and its loss during propofol anaesthesia. Specifically, we use dynamic causal modelling (DCM) of 10 min of high-density EEG recordings (N = 10, 4 males) obtained during behavioural responsiveness, unconsciousness and post-anaesthetic recovery to characterise differences in effective connectivity within frontal areas, the posterior 'hot zone', frontoparietal connections, and between-RSN connections. We estimate - for the first time - a large DCM model (LAR) of resting EEG, combining the three RSNs into a rich club of interconnectivity. Consistent with the hot zone theory, our findings demonstrate reductions in inter-RSN connectivity in the parietal cortex. Within the DMN itself, the strongest reductions are in feed-forward frontoparietal and parietal connections at the precuneus node. Within the SAL and CEN, loss of consciousness generates small increases in bidirectional connectivity. Using novel DCM leave-one-out cross-validation, we show that the most consistent out-of-sample predictions of the state of consciousness come from a key set of frontoparietal connections. This finding also generalises to unseen data collected during post-anaesthetic recovery. Our findings provide new, computational evidence for the importance of the posterior hot zone in explaining the loss of consciousness, highlighting also the distinct role of frontoparietal connectivity in underpinning conscious responsiveness, and consequently, suggest a dissociation between the mechanisms most prominently associated with explaining the contrast between conscious awareness and unconsciousness, and those maintaining consciousness.
Published: 2021

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