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10 results on '"University of Helsinki, Lastentaudit (-2009)"'

1. Diurnal Cortisol Patterns and Dexamethasone Suppression Test Responses in Healthy Young Adults Born Preterm at Very Low Birth Weight

Author

University of Helsinki, Institute of Behavioural Sciences, University of Helsinki, Lastentaudit (-2009), University of Helsinki, Clinicum, University of Helsinki, Hospital for Children and Adolescents, Kaseva, Nina, Pyhälä-Neuvonen, Riikka, Pesonen, Anu-Katriina, Räikkönen, Katri, Järvenpää, Anna-Liisa, Andersson, Sture, Eriksson, Johan G., Hovi, Petteri, Kajantie, Eero, University of Helsinki, Institute of Behavioural Sciences, University of Helsinki, Lastentaudit (-2009), University of Helsinki, Clinicum, University of Helsinki, Hospital for Children and Adolescents, Kaseva, Nina, Pyhälä-Neuvonen, Riikka, Pesonen, Anu-Katriina, Räikkönen, Katri, Järvenpää, Anna-Liisa, Andersson, Sture, Eriksson, Johan G., Hovi, Petteri, and Kajantie, Eero

Abstract

BACKGROUND: Early life stress, such as painful and stressful procedures during neonatal intensive care after preterm birth, can permanently affect physiological, hormonal and neurobiological systems. This may contribute to altered programming of the hypothalamic-pituitary-adrenal axis (HPAA) and provoke changes in HPAA function with long-term health impacts. Previous studies suggest a lower HPAA response to stress in young adults born preterm compared with controls born at term. We assessed whether these differences in HPAA stress responsiveness are reflected in everyday life HPAA functioning, i.e. in diurnal salivary cortisol patterns, and reactivity to a low-dose dexamethasone suppression test (DST), in unimpaired young adults born preterm at very low birth weight (VLBW; <1500 g). METHODS: The participants were recruited from the Helsinki Study of Very Low Birth Weight Adults cohort study. At mean age 23.3 years (2.1 SD), 49 VLBW and 36 controls born at term participated in the study. For cortisol analyzes, saliva samples were collected on two consecutive days at 0, 15, 30 and 60 min after wake-up, at 12:00 h, 17:00 h and 22:00 h. After the last salivary sample of the first study day the participants were instructed to take a 0.5 mg dexamethasone tablet. RESULTS: With mixed-effects model no difference was seen in overall diurnal salivary cortisol between VLBW and control groups [13.9% (95% CI: -11.6, 47.0), P = 0.31]. Salivary cortisol increased similarly after awakening in both VLBW and control participants [mean difference -2.9% (29.2, 33.0), P = 0.85]. Also reactivity to the low-dose DST (awakening cortisol ratio day2/day1) was similar between VLBW and control groups [-1.1% (-53.5, 103.8), P = 0.97)]. CONCLUSIONS: Diurnal cortisol patterns and reactivity to a low-dose DST in young adulthood were not associated with preterm birth.

Published
2016

2. Behavioral Abnormalities in Lagotto Romagnolo Dogs with a History of Benign Familial Juvenile Epilepsy

Author

University of Helsinki, Faculty of Veterinary Medicine, University of Helsinki, Lastentaudit (-2009), University of Helsinki, Research Programs Unit, Jokinen, T. S., Tiira, K., Metsähonkala, L., Seppala, E. H., Hielm-Bjorkman, A., Lohi, H., Laitinen-Vapaavuori, O., University of Helsinki, Faculty of Veterinary Medicine, University of Helsinki, Lastentaudit (-2009), University of Helsinki, Research Programs Unit, Jokinen, T. S., Tiira, K., Metsähonkala, L., Seppala, E. H., Hielm-Bjorkman, A., Lohi, H., and Laitinen-Vapaavuori, O.

Abstract

BackgroundLagotto Romagnolo (LR) dogs with benign juvenile epilepsy syndrome often experience spontaneous remission of seizures. The long-term outcome in these dogs currently is unknown. In humans, behavioral and psychiatric comorbidities have been reported in pediatric and adult-onset epilepsies. Hypothesis/ObjectivesThe objectives of this study were to investigate possible neurobehavioral comorbidities in LR with a history of benign familial juvenile epilepsy (BFJE) and to assess the occurrence of seizures after the remission of seizures in puppyhood. AnimalsA total of 25 LR with a history of BFJE and 91 control dogs of the same breed. MethodsOwners of the LR dogs in the BFJE and control groups completed an online questionnaire about each dog's activity, impulsivity, and inattention. Principal component analysis (PCA) served to extract behavioral factors from the data. We then compared the scores of these factors between the 2 groups in a retrospective case-control study. We also interviewed all dog owners in the BFJE group by telephone to inquire specifically about possible seizures or other neurological problems after remission of seizures as a puppy. ResultsLagotto Romagnolo dogs with BFJE showed significantly higher scores on the factors Inattention and Excitability/Impulsivity than did the control group (P=.003; P=.021, respectively). Only 1 of the 25 BFJE LR exhibited seizures after remission of epilepsy in puppyhood. Conclusions and Clinical ImportanceAlthough the long-term seizure outcome in BFJE LR seems to be good, the dogs exhibit behavioral abnormalities resembling attention deficit hyperactivity disorder (ADHD) in humans, thus suggesting neurobehavioral comorbidities with epilepsy.

Published
2015

3. Infant Growth after Preterm Birth and Mental Health in Young Adulthood

Author

University of Helsinki, Clinicum, University of Helsinki, Institute of Behavioural Sciences, University of Helsinki, Lastentaudit (-2009), University of Helsinki, Hospital for Children and Adolescents, Sammallahti, Sara, Lahti, Marius, Pyhala, Riikka, Lahti, Jari, Pesonen, Anu-Katriina, Heinonen, Kati, Hovi, Petteri, Eriksson, Johan G., Strang-Karlsson, Sonja, Jarvenpaa, Anna-Liisa, Andersson, Sture, Kajantie, Eero, Räikkönen, Katri, University of Helsinki, Clinicum, University of Helsinki, Institute of Behavioural Sciences, University of Helsinki, Lastentaudit (-2009), University of Helsinki, Hospital for Children and Adolescents, Sammallahti, Sara, Lahti, Marius, Pyhala, Riikka, Lahti, Jari, Pesonen, Anu-Katriina, Heinonen, Kati, Hovi, Petteri, Eriksson, Johan G., Strang-Karlsson, Sonja, Jarvenpaa, Anna-Liisa, Andersson, Sture, Kajantie, Eero, and Räikkönen, Katri

Abstract

Objectives Faster growth after preterm birth benefits long-term cognitive functioning. Whether these benefits extend to mental health remains largely unknown. We examined if faster growth in infancy is associated with better self-reported mental health in young adults born preterm at very low birth weight (VLBW) ( Study Design As young adults, participants of the Helsinki Study of Very Low Birth Weight Adults self-reported symptoms of depression and attention deficit/hyperactivity disorder (ADHD) (n = 157) and other psychiatric problems (n = 104). As main predictors of mental health outcomes in linear regression models, we used infant weight, length, and head circumference at birth, term, and 12 months of corrected age, and growth between these time points. Growth data were collected from records and measures at term and at 12 months of corrected age were interpolated. Additionally, we examined the moderating effects of intrauterine growth restriction. Results Size at birth, term, or 12 months of corrected age, or growth between these time points were not associated with mental health outcomes (p-values >0.05). Intrauterine growth restriction did not systematically moderate any associations. Conclusions Despite the high variability in early growth of VLBW infants, the previously described association between slow growth in infancy and poorer cognitive functioning in later life is not reflected in symptoms of depression, ADHD, and other psychiatric problems. This suggests that the development of cognitive and psychiatric problems may have dissimilar critical periods in VLBW infants.

Published
2015

4. Childhood femoral fracture can lead to premature knee-joint arthritis

Author

University of Helsinki, Clinicum, University of Helsinki, Lastentaudit (-2009), University of Helsinki, Hospital for Children and Adolescents, Palmu, Sauli A., Lohman, Martina, Paukku, Reijo T., Peltonen, Jari I., Nietosvaara, Yrjana, University of Helsinki, Clinicum, University of Helsinki, Lastentaudit (-2009), University of Helsinki, Hospital for Children and Adolescents, Palmu, Sauli A., Lohman, Martina, Paukku, Reijo T., Peltonen, Jari I., and Nietosvaara, Yrjana

Published
2013

5. Lipoprotein subclass profiles in young adults born preterm at very low birth weight

Author

University of Helsinki, Clinicum, University of Helsinki, Hospital for Children and Adolescents, University of Helsinki, Lastentaudit (-2009), Hovi, Petteri, Kajantie, Eero, Soininen, Pasi, Kangas, Antti J., Järvenpää, Anna-Liisa, Andersson, Sture, Eriksson, Johan G., Ala-Korpela, Mika, Wehkalampi, Karoliina, University of Helsinki, Clinicum, University of Helsinki, Hospital for Children and Adolescents, University of Helsinki, Lastentaudit (-2009), Hovi, Petteri, Kajantie, Eero, Soininen, Pasi, Kangas, Antti J., Järvenpää, Anna-Liisa, Andersson, Sture, Eriksson, Johan G., Ala-Korpela, Mika, and Wehkalampi, Karoliina

Published
2013

6. High-resolution SNP array analysis of patients with developmental disorder and normal array CGH results

Author

University of Helsinki, Department of Pathology, University of Helsinki, Haartman Institute (-2009), University of Helsinki, Hospital for Children and Adolescents, University of Helsinki, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Lastentaudit (-2009), Siggberg, Linda, Ala-Mello, Sirpa, Linnankivi, Tarja, Avela, Kristiina, Scheinin, Ilari, Kristiansson, Kati, Lahermo, Päivi, Hietala, Marja, Metsähonkala, Eeva-Liisa, Kuusinen, Esa, Laaksonen, Maarit, Saarela, Janna, Knuutila, Sakari, University of Helsinki, Department of Pathology, University of Helsinki, Haartman Institute (-2009), University of Helsinki, Hospital for Children and Adolescents, University of Helsinki, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Lastentaudit (-2009), Siggberg, Linda, Ala-Mello, Sirpa, Linnankivi, Tarja, Avela, Kristiina, Scheinin, Ilari, Kristiansson, Kati, Lahermo, Päivi, Hietala, Marja, Metsähonkala, Eeva-Liisa, Kuusinen, Esa, Laaksonen, Maarit, Saarela, Janna, and Knuutila, Sakari

Published
2012

7. Lower Conditioning Leisure-Time Physical Activity in Young Adults Born Preterm at Very Low Birth Weight

Author

University of Helsinki, Hospital for Children and Adolescents, University of Helsinki, Clinicum, University of Helsinki, Department of Public Health, University of Helsinki, Institute of Behavioural Sciences, University of Helsinki, Lastentaudit (-2009), Kaseva, Nina, Wehkalampi, Karoliina, Strang-Karlsson, Sonja, Salonen, Minna, Pesonen, Anu-Katriina, Räikkönen, Katri, Tammelin, Tuija, Hovi, Petteri, Lahti, Jari, Heinonen, Kati, Jarvenpaa, Anna-Liisa, Andersson, Sture, Eriksson, Johan G., Kajantie, Eero, University of Helsinki, Hospital for Children and Adolescents, University of Helsinki, Clinicum, University of Helsinki, Department of Public Health, University of Helsinki, Institute of Behavioural Sciences, University of Helsinki, Lastentaudit (-2009), Kaseva, Nina, Wehkalampi, Karoliina, Strang-Karlsson, Sonja, Salonen, Minna, Pesonen, Anu-Katriina, Räikkönen, Katri, Tammelin, Tuija, Hovi, Petteri, Lahti, Jari, Heinonen, Kati, Jarvenpaa, Anna-Liisa, Andersson, Sture, Eriksson, Johan G., and Kajantie, Eero

Published
2012

8. Premenstrual symptoms in young adults born preterm at very low birth weight - from the Helsinki Study of Very Low Birth Weight Adults

Author

University of Helsinki, Institute of Behavioural Sciences, University of Helsinki, Lastentaudit (-2009), University of Helsinki, Department of General Practice and Primary Health Care, University of Helsinki, Hospital for Children and Adolescents, Mustaniemi, Sanna, Sipola-Leppänen, Marika, Hovi, Petteri, Halbreich, Uriel, Vääräsmäki, Marja, Räikkönen, Katri, Pesonen, Anu-Katriina, Heinonen, Kati, Järvenpää, Anna-Liisa, Eriksson, Johan G., Andersson, Sture, Kajantie, Eero, University of Helsinki, Institute of Behavioural Sciences, University of Helsinki, Lastentaudit (-2009), University of Helsinki, Department of General Practice and Primary Health Care, University of Helsinki, Hospital for Children and Adolescents, Mustaniemi, Sanna, Sipola-Leppänen, Marika, Hovi, Petteri, Halbreich, Uriel, Vääräsmäki, Marja, Räikkönen, Katri, Pesonen, Anu-Katriina, Heinonen, Kati, Järvenpää, Anna-Liisa, Eriksson, Johan G., Andersson, Sture, and Kajantie, Eero

Published
2011

9. Resting Energy Expenditure in Young Adults Born Preterm-The Helsinki Study of Very Low Birth Weight Adults

Author

University of Helsinki, Hospital for Children and Adolescents, University of Helsinki, Clinicum, University of Helsinki, Lastentaudit (-2009), University of Helsinki, Department of General Practice and Primary Health Care, Sipola-Leppänen, Marika, Hovi, Petteri, Andersson, Sture, Wehkalampi, Karoliina, Vääräsmäki, Marja, Strang-Karlsson, Sonja, Järvenpää, Anna-Liisa, Mäkitie, Outi, Eriksson, Johan G., Kajantie, Eero, University of Helsinki, Hospital for Children and Adolescents, University of Helsinki, Clinicum, University of Helsinki, Lastentaudit (-2009), University of Helsinki, Department of General Practice and Primary Health Care, Sipola-Leppänen, Marika, Hovi, Petteri, Andersson, Sture, Wehkalampi, Karoliina, Vääräsmäki, Marja, Strang-Karlsson, Sonja, Järvenpää, Anna-Liisa, Mäkitie, Outi, Eriksson, Johan G., and Kajantie, Eero

Published
2011

10. Normal growth and intravascular volume status with good metabolic control during peritoneal dialysis in infancy

Author

University of Helsinki, Hospital for Children and Adolescents, University of Helsinki, Radiologian yksikkö (-2009), University of Helsinki, Lastentaudit (-2009), Laakkonen, Hanne, Happonen, Juha-Matti, Marttinen, Eino, Paganus, Aila, Holtta, Tuula, Holmberg, Christer, Rönnholm, Kai, University of Helsinki, Hospital for Children and Adolescents, University of Helsinki, Radiologian yksikkö (-2009), University of Helsinki, Lastentaudit (-2009), Laakkonen, Hanne, Happonen, Juha-Matti, Marttinen, Eino, Paganus, Aila, Holtta, Tuula, Holmberg, Christer, and Rönnholm, Kai

Published
2010

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