Search

Your search keyword '"University of Brussels"' showing total 4,697 results
Start Over Author "University of Brussels"
4,697 results on '"University of Brussels"'

7. Effect of Physiotherapeutic Interventions on Quality of Life in Patients With Chronic Low Back Pain. (Study 1) (CLBP)

Author

Approved by the Committee of Medical Ethics University Hospital University of Brussels, B.U.N. 143201627110., Insurance on experiment on human subjects by ethias liability policy: 45.147.458, The EuroQol Research Foundation, This research is supported by the Fysio Science Institute® and is a non-profit institution., and Robbert van Amstel, Physical therapist, Master of science and manual therapist student

Published
2017

8. Core Strength Training in Youth

Author

THIM - die internationale Hochschule für Physiotherapie, Free University of Brussels, and Urs Granacher, Prof. Dr.

Published
2014

9. Your Planet or Your Career! The Academic Flyers’ Dilemma: Perception or Reality?

Author

the workshop "Minimising the impact of aviation emissions: what way forward?" organised at the Maastricht University Campus Brussels (21-22/10/2019: Brussels, Belgium), Weikmans, Romain, the workshop "Minimising the impact of aviation emissions: what way forward?" organised at the Maastricht University Campus Brussels (21-22/10/2019: Brussels, Belgium), and Weikmans, Romain

Abstract

info:eu-repo/semantics/nonPublished

Published
2019

11. Anti-cancer and anti-viral function of human γδ T cells

Author

Institut de biologie et de médecine moléculaires (IBMM) (March 22, 2011: University of Brussels, Belgium.), Vermijlen, David, Institut de biologie et de médecine moléculaires (IBMM) (March 22, 2011: University of Brussels, Belgium.), and Vermijlen, David

Abstract

info:eu-repo/semantics/nonPublished

Published
2011

12. Covering Post-Conflict Elections: Challenges for the Media in Central Africa

Author

Panos Paris Institute, Marie-Soleil Frère; University of Brussels, Panos Paris Institute, and Marie-Soleil Frère; University of Brussels

Abstract

In the past ten years, elections were held in six countries of Central Africa experiencing “post-conflict” situations. The polls that took place in Burundi (2005), the Central African Republic (2005), the Democratic Republic of the Congo (2006), Congo-Brazzaville (2002, 2007), Chad (1996, 2001, 2006) and Rwanda (2003) were crucial for peace-building. In some cases, they were widely supported and supervised by the international community, being considered the last step of a peace process and the first step toward establishing a truly representative “post-conflict” regime. The media were expected to play a large part in supporting these elections, both to inform the citizens, so they could make an educated choice, and to supervise the way the electoral administration was organizing the polls. This paper attempts to show the many challenges faced by the media while covering these post-conflict electoral processes. In a context of great political tension, in which candidates are often former belligerents who have just put down their guns to go to the polls, the media operate in an unsafe and economically damaged environment, suffering from a lack of infrastructure, inadequate equipment and untrained staff. Given those constraints, one might wonder if the media should be considered actual democratic tools in Central Africa or just gimmicks in a “peace-building kit” (including “free and fair” elections, multipartism and freedom of the press) with no real impact on the democratic commitment of the elite or the political participation of the population., In den letzten zehn Jahren wurden in sechs zentralafrikanischen Ländern, die sich in einer Post-Konflikt-Phase befanden, Wahlen abgehalten. Die Wahlgänge in Burundi (2005), der Zentralafrikanischen Republik (2005), der Demokratischen Republik Kongo (2006), Kongo-Brazzaville (2002, 2007), dem Tschad (1996, 2001, 2006) und Ruanda (2003) waren entscheidend für die Friedenskonsolidierung. Einige dieser Wahlen wurden von der internationalen Gemeinschaft umfassend unterstützt und überwacht, denn sie wurden als letzte Stufe des Friedensprozesses und erster Schritt hin zu einer repräsentativen politischen Ordnung angesehen. Den Medien wurde eine wichtige Rolle zur Unterstützung dieser Wahlen zugeschrieben, sowohl in Bezug auf die Information der Bürger, damit diese eine auf Kenntnissen beruhende Entscheidung treffen könnten, als auch auf die Überwachung der Organisation der Wahlen durch die Verwaltung. Dieser Beitrag versucht, die vielen Herausforderungen zu zeigen, denen sich die Medien bei der Wahlberichterstattung ausgesetzt sahen. In einer Situation starker politischer Spannung, in der die Kandidaten häufig ehemalige Kriegsteilnehmer sind, die ihre Waffen nur für den Wahlgang niedergelegt haben, operieren die Medien in einem Umfeld, das durch Unsicherheit und wirtschaftliche Zerstörung gekennzeichnet ist. Ihre Arbeit leidet unter der mangelhaften Infrastruktur, ihrer ungenügenden Ausrüstung und nicht ausreichend qualifizierten Mitarbeitern. Angesichts dieser Unzulänglichkeiten ist fraglich, ob die Medien in Zentralafrika wirklich als Instrumente der Demokratisierung angesehen werden können oder (wie auch „freie und faire“ Wahlen, Mehrparteiensystem und Pressefreiheit) eher als ein Element aus dem „Peacebuilding-Bau-satz“ ohne wirkliche Bedeutung für die demokratische Einstellung der Elite oder die politische Partizipation der Bevölkerung.

Published
2011

13. Brussels in its pre-urbanistic days

Author

USL-B - Centre d'études sociologiques (CES), Zitouni, Benedikte, Urban Studies Network de la UAB - University Association Brussels à la Vrije Universiteit Brussel, USL-B - Centre d'études sociologiques (CES), Zitouni, Benedikte, and Urban Studies Network de la UAB - University Association Brussels à la Vrije Universiteit Brussel

Abstract

There are many benefits at looking at the pre-urbanistic days of Brussels, i.e. the time when urbanism was not yet coined nor practiced as a profession, while the rapid urbanisation process was already taking place. In Agglomérer, set in the 19th Century, three benefits are present. They all relate to the way in which we, local researchers in urban studies, usually conceive - or should I say misconceive ? - 19th Century planning practice. First of all, the fragmented nature of Brussels is often traced back to the failure of 1854, when National Parliament decided to maintain municipal autonomy in the Brussels surroundings. The city-center would not be reunited into one bigger ur- ban entity. Still today, the 19 municpalities are held responsible for a lot of the city’s misfortunes. Instead, the book shows that the surroundings have been unified, consolidated, that the failure of 1854 was overcome, and that the territorial unity had nothing to do with municipal borders, but proceeded from the ways in which houses and streets were moulded in an overall coherent manner. There’s a difference between municipal unity and agglomerated of pre-urbanistic unity.

Published
2010

14. Stress Analysis of a Tooth Restored with a Post and Core

Author

Department of Dental Materials, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109, Department of Cariology and Endodontology, University of Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands, School of Dentistry, Academic Hospital V.U.B., Free University of Brussels, Belgium, Peters, M. C. R. B., Poort, H. W., Farah, J. W., Craig, R. G., Department of Dental Materials, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109, Department of Cariology and Endodontology, University of Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands, School of Dentistry, Academic Hospital V.U.B., Free University of Brussels, Belgium, Peters, M. C. R. B., Poort, H. W., Farah, J. W., and Craig, R. G.

Abstract

An idealized axisymmetric finite element model of a second premolar restored with a post and core was used to study the distribution and magnitude of stresses as a function of the following parameters : the diameter of the post, the length and the shape of the post, and finally the interface characteristics between post and cement. Emphasis was directed toward the cement layer interposed between the post and the tooth. Bonding between the post and the cement appeared to be the most important parameter to achieve optimal mechanical behavior of the tooth-prosthesis combination.

Published
2010

15. Shapes and Uses of Greek Vases (7th-4th c. B.C.)

Author

Proceedings of the International Symposium held (27-29th April 2006: the University of Brussels (ULB)), Tsingarida, Athena, Proceedings of the International Symposium held (27-29th April 2006: the University of Brussels (ULB)), and Tsingarida, Athena

Abstract

0, info:eu-repo/semantics/published

Published
2009

16. Observations on the pollination of Ophrys fuciflora by pseudocopulating males of Phyllopertha horticola in northern France

Author

UCL - SC/BIOL - Département de biologie, Universidade Lusofona de Humanidades e Tecnologias, Lisboa, Portuga, Free University of Brussels - Evolutionary Biology & Ecology, UCL - SST/ELI/ELIB - Biodiversity, Tyteca, Daniel, Róis, Ana Sofia, Vereecken, Nicolas J, UCL - SC/BIOL - Département de biologie, Universidade Lusofona de Humanidades e Tecnologias, Lisboa, Portuga, Free University of Brussels - Evolutionary Biology & Ecology, UCL - SST/ELI/ELIB - Biodiversity, Tyteca, Daniel, Róis, Ana Sofia, and Vereecken, Nicolas J

Published
2006

17. Brain Drain in Developing Regions (1990-2000)

Author

University of Lille 2 - CADRE, Regional Governement of Wallonia - IWEPS, Free University of Brussels, Docquier, Frédéric, Lohest, Olivier, Marfouk, Addeslam, University of Lille 2 - CADRE, Regional Governement of Wallonia - IWEPS, Free University of Brussels, Docquier, Frédéric, Lohest, Olivier, and Marfouk, Addeslam

Abstract

In this paper, we analyze the distribution of the brain drain in the LAC region (Latin America and the Caribbean), Asia and Africa. We rely on an original data set on international migration by educational attainment for 1990 and 2000. Our analysis reveals that the brain drain is strong in Eastern, Middle and Western Africa, Central America and the Caribbean. However, the Kernel approach suggests that the dispersion and the intradistribution dynamics of skilled migration rates strongly differ across regions. We then tautologically disentangle the brain drain into two multiplicative components, the global migration rate and the selection bias. Among the most affected countries, LAC countries suffer from high migration rates whilst most African countries suffer from high selection biases. Finally, exploratory Moran's tests reveal strong spatial, political and cultural autocorrelations in migration rates and selection biases. The latter result suggests that skilled workers react differently than unskilled workers to a large set of variables.

Published
2006

19. Tuberculose: Expérience depuis 1994

Author

Séminaire de Pédiatrie (19 June 2003: Saint-Pierre University Hospital Brussels), Vandenberg, Olivier, Séminaire de Pédiatrie (19 June 2003: Saint-Pierre University Hospital Brussels), and Vandenberg, Olivier

Abstract

info:eu-repo/semantics/nonPublished

Published
2003

20. Monetary policy rules in an interdependent world

Author

ECARES (December 2002: Free university of Brussels, Brussels, Belgium), Kollmann, Robert, ECARES (December 2002: Free university of Brussels, Brussels, Belgium), and Kollmann, Robert

Abstract

info:eu-repo/semantics/nonPublished

Published
2002

21. Arthrite septique

Author

Séminaire de Chirurgie (28 September 2002: Saint-Pierre University Hospital, Brussels), Vandenberg, Olivier, Séminaire de Chirurgie (28 September 2002: Saint-Pierre University Hospital, Brussels), and Vandenberg, Olivier

Abstract

info:eu-repo/semantics/nonPublished

Published
2002

22. Septicémie à germes entéropathogènes

Author

Séminaire de Pédiatrie (04 January 2001: Saint-Pierre University Hospital, Brussels), Vandenberg, Olivier, Séminaire de Pédiatrie (04 January 2001: Saint-Pierre University Hospital, Brussels), and Vandenberg, Olivier

Abstract

info:eu-repo/semantics/nonPublished

Published
2001

23. Diarrhée sanglante

Author

Séminaire de Pédiatrie (28 September 2000: Saint-Pierre University Hospital, Brussels), Vandenberg, Olivier, Séminaire de Pédiatrie (28 September 2000: Saint-Pierre University Hospital, Brussels), and Vandenberg, Olivier

Abstract

info:eu-repo/semantics/nonPublished

Published
2000

24. Speech

Author

Inauguration of the Prigogine Seminar at the University of Brussels (13 November 1997) at the occasion of the 20 years of his receiving the Nobel Prize (13 November 1997: Brussels), Prigogine, Ilya, Inauguration of the Prigogine Seminar at the University of Brussels (13 November 1997) at the occasion of the 20 years of his receiving the Nobel Prize (13 November 1997: Brussels), and Prigogine, Ilya

Abstract

info:eu-repo/semantics/nonPublished

Published
1997

25. The collection of Data on Racial or Ethnic Origins for Antidiscrimination Policies: Equality, Privacy, and Diversity in European Perspective

Author

Centre for Philosophy of Law ( CPDR ), Catholic University of Louvain in cooperation with the Centre for Human Rights of the University of Ghent ( Human Rights Centre ) and the MAM (09-11-2007: Free University of Brussels ( ULB ), Bruxelles), Bribosia, Emmanuelle, Centre for Philosophy of Law ( CPDR ), Catholic University of Louvain in cooperation with the Centre for Human Rights of the University of Ghent ( Human Rights Centre ) and the MAM (09-11-2007: Free University of Brussels ( ULB ), Bruxelles), and Bribosia, Emmanuelle

Abstract

info:eu-repo/semantics/nonPublished

27. Glioma-derived galectin-1 regulates innate and adaptive antitumor immunity

Author

Tina, Verschuere, Jaan, Toelen, Wim, Maes, Françoise, Poirier, Louis, Boon, Thomas, Tousseyn, Thomas, Mathivet, Holger, Gerhardt, Veronique, Mathieu, Robert, Kiss, Florence, Lefranc, Stefaan W, Van Gool, Steven, De Vleeschouwer, Department of Neurosciences, Laboratory of Experimental Neurosurgery and Neuroanatomy, Laboratory of Experimental Neurosurgery and Neuroanatomy, Department of Development and Regeneration, Laboratory for Thrombosis Research, IRF Life Sciences (KULAK), Laboratory for Thrombosis Research, PharmAb, The KU Leuven Antibody Center, The KU Leuven Antibody Center, Institut Jacques Monod (IJM (UMR_7592)), Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Bioceros BV, Department of Imaging and Pathology, Translational Cell and Tissue Research, Translational Cell and Tissue Research, Department of Oncology, Vascular Patterning Laboratory, Vesalius Research Center, Vesalius Research Center, Vascular Biology Laboratory, London Research Institute - Cancer Research UK, Lincoln's Inn Fields Laboratories, Cancer Research UK London Research Institute, Free University of Brussels, Laboratory of Toxicology, Faculty of Pharmacy (ULB), Faculty of Pharmacy-Free University of Brussels (BELGIUM), Department of Neurosurgery, Erasmus University Hospital, Erasmus University Hospital, Department of Microbiology and Immunology, Laboratory of Pediatric Immunology, Laboratory of Pediatric Immunology, Department of Neurosciences, Institute for the Promotion of Innovation by Science and Technology in Flanders (IWT Vlaanderen), Klinisch Onderzoeksfonds UZ Leuven, Fund for Scientific Research, Flanders (FWO-V), Fonds National de la Recherche Scientifique (FRS-FNRS Belgium), Herman Memorial Research Fund, Olivia Hendrickx Research fund, James E. Kearney Foundation, Belgian Brain Tumor Support (BBTS), Faculté de Pharmacie [Bruxelles] (ULB), and Université libre de Bruxelles (ULB)

Subjects
Galectin 1, MESH: Immunotherapy, MESH: Flow Cytometry, Adaptive Immunity, MESH: Mice, Knockout, Immunoenzyme Techniques, MESH: Glioma, Mice, angiogenesis, MESH: Reverse Transcriptase Polymerase Chain Reaction, Tumor Cells, Cultured, Myeloid Cells, MESH: Animals, Mice, Knockout, Neovascularization, Pathologic, MESH: Dendritic Cells, Brain Neoplasms, Reverse Transcriptase Polymerase Chain Reaction, MESH: Antigen-Presenting Cells, MESH: Real-Time Polymerase Chain Reaction, Glioma, Flow Cytometry, MESH: Brain Neoplasms, Female, MESH: Immunity, Innate, Immunotherapy, Blotting, Western, Antigen-Presenting Cells, [SDV.CAN]Life Sciences [q-bio]/Cancer, Real-Time Polymerase Chain Reaction, tumor-infiltrating myeloid cells, MESH: Mice, Inbred C57BL, MESH: Cell Proliferation, Biomarkers, Tumor, otorhinolaryngologic diseases, Animals, galectin-1, MESH: Blotting, Western, RNA, Messenger, MESH: Tumor Cells, Cultured, MESH: Immunoenzyme Techniques, MESH: Mice, Cell Proliferation, MESH: RNA, Messenger, MESH: Galectin 1, glioblastoma, Dendritic Cells, MESH: Myeloid Cells, Immunity, Innate, Mice, Inbred C57BL, Disease Models, Animal, MESH: Tumor Markers, Biological, dendritic cell immunotherapy, MESH: Disease Models, Animal, MESH: Neovascularization, Pathologic, MESH: Female, MESH: Adaptive Immunity
Abstract

International audience; Galectin-1 is a glycan-binding protein, which is involved in the aggressiveness of glioblastoma (GBM) in part by stimulating angiogenesis. In different cancer models, galectin-1 has also been demonstrated to play a pivotal role in tumor-mediated immune evasion especially by modulating cells of the adaptive immune system. It is yet unknown whether the absence or presence of galectin-1 within the glioma microenvironment also causes qualitative or quantitative differences in innate and/or adaptive antitumor immune responses. All experiments were performed in the orthotopic GL261 mouse high-grade glioma model. Stable galectin-1 knockdown was achieved via transduction of parental GL261 tumor cells with a lentiviral vector encoding a galectin-1-targeting miRNA. We demonstrated that the absence of tumor-derived but not of host-derived galectin-1 significantly prolonged the survival of glioma-bearing mice as such and in combination with dendritic cell (DC)-based immunotherapy. Both flow cytometric and pathological analysis revealed that the silencing of glioma-derived galectin-1 significantly decreased the amount of brain-infiltrating macrophages and myeloid-derived suppressor cells (MDSC) in tumor-bearing mice. Additionally, we revealed a pro-angiogenic role for galectin-1 within the glioma microenvironment. The data provided in this study reveal a pivotal role for glioma-derived galectin-1 in the regulation of myeloid cell accumulation within the glioma microenvironment, the most abundant immune cell population in high-grade gliomas. Furthermore, the prolonged survival observed in untreated and DC-vaccinated glioma-bearing mice upon the silencing of tumor-derived galectin-1 strongly suggest that the in vivo targeting of tumor-derived galectin-1 might offer a promising and realistic adjuvant treatment modality in patients diagnosed with GBM.

Published
2014

28. Biological and hemodynamic effects of low doses of fludrocortisone and hydrocortisone, alone or in combination, in healthy volunteers with hypoaldosteronism

Author

F. Laine, Eric Bellissant, Marie-Clémence Verdier, Bruno Laviolle, Audrey Lavenu, Erwan Donal, Catherine Massart, Danielle Pape, P. Le Maguet, Pharmacologie du Sepsis et Choc Septique, Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM)-Service de Pharmacologie [Rennes], CHU Pontchaillou [Rennes]-CHU Pontchaillou [Rennes], Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Unité Laboratoire CIC, Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM)-University of Brussels, University of Brussels-University of Brussels, Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), Fer et Métabolismes, Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM)-Foie, métabolismes et cancer, Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Modélisation PK et PK-PD, Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM)-Service de Pharmacologie [Rennes], Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM)-University of Brussels, Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM)-Foie, métabolismes et cancer, and Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )

Subjects
Blood Glucose, Male, Hydrocortisone, MESH: Renin, Anti-Inflammatory Agents, Hemodynamics, 030204 cardiovascular system & hematology, 0302 clinical medicine, Renin, MESH: Sodium, Pharmacology (medical), MESH: Double-Blind Method, 030212 general & internal medicine, MESH: Hypoaldosteronism, Aldosterone, Cross-Over Studies, Water-Electrolyte Balance, [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences, MESH: Hydrocortisone, 3. Good health, MESH: Young Adult, Fludrocortisone, Corticosteroid, [SDV.IB]Life Sciences [q-bio]/Bioengineering, Hypoaldosteronism, medicine.drug, Adult, medicine.medical_specialty, MESH: Hemodynamics, medicine.drug_class, MESH: Cross-Over Studies, 03 medical and health sciences, Young Adult, Double-Blind Method, Internal medicine, medicine, Humans, MESH: Fludrocortisone, MESH: Urodynamics, Pharmacology, MESH: Humans, business.industry, Septic shock, Sodium, MESH: Aldosterone, MESH: Adult, medicine.disease, Crossover study, MESH: Male, Urodynamics, Endocrinology, Mineralocorticoid, MESH: Anti-Inflammatory Agents, MESH: Water-Electrolyte Balance, MESH: Blood Glucose, business
Abstract

International audience; Low doses of hydrocortisone (HC) and fludrocortisone (FC) administered together improve the prognosis after septic shock; however, there continues to be disagreement about the utility of FC for this indication. The biological and hemodynamic effects of HC (50 mg intravenously) and FC (50 microg orally) were assessed in 12 healthy male volunteers with saline-induced hypoaldosteronism in a placebo-controlled, randomized, double-blind, crossover study performed according to a 2 x 2 factorial design. HC and FC significantly decreased urinary sodium and potassium levels (from -58% at 4 h to -28% at 10 h and from -35% at 8 h to -24% at 12 h, respectively) with additive effects. At 4 h after administration, HC significantly increased cardiac output (+14%), decreased systemic vascular resistances (-14%), and slightly increased heart rate (+4 beats/min), whereas FC had no hemodynamic effect. At doses used in septic shock, HC induced greater mineralocorticoid effect than FC did. HC also induced transient systemic hemodynamic effects, whereas FC did not. New studies are required to better define the optimal dose of FC in septic shock.

Published
2010

29. Tomographies Optiques et NeuroImageries Rhône-alpines chez le petit animal

Author

Mottin, S., Vial, J.C., Montcel, B., Douady, J., Olivier, T., Sanden, B., Moine, B., Lefkir, Y., Appaix, F., Abi-Haidar, D., Massart, C., Palle, S., Cottet, D., Wege, H., Mathevon, N., Maurin, M., Vignal, C., Cespuglio, R., Laboratoire Hubert Curien (LHC), Institut d'Optique Graduate School (IOGS)-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Spectrométrie Physique (LSP), Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Grenoble Institut des Neurosciences (GIN), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Unité Laboratoire CIC, Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM)-University of Brussels, Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB), Ecologie comportementale (EC), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Recherche Agronomique (INRA)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université de Rennes (UR)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Adaptation et pathogénie des micro-organismes [Grenoble] (LAPM), Neurobiologie des états de veille et de sommeil (EA3734), Université de Lyon-Université de Lyon-Centre Hospitalier le Vinatier [Bron], Montcel, Bruno, Laboratoire Hubert Curien [Saint Etienne] (LHC), Université Jean Monnet [Saint-Étienne] (UJM)-Centre National de la Recherche Scientifique (CNRS)-Institut d'Optique Graduate School (IOGS), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Grenoble-Université Joseph Fourier - Grenoble 1 (UJF), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM)-University of Brussels, University of Brussels-University of Brussels, École normale supérieure - Paris (ENS Paris)-Institut National de la Recherche Agronomique (INRA)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université Claude Bernard Lyon 1 (UCBL), Centre Hospitalier le Vinatier [Bron]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Institut d'Optique Graduate School (IOGS)-Université Jean Monnet [Saint-Étienne] (UJM)-Centre National de la Recherche Scientifique (CNRS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Recherche Agronomique (INRA)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université de Rennes 1 (UR1), and Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)

Subjects
[SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, imagerieₘethodologie_RMN, [INFO.INFO-IM] Computer Science [cs]/Medical Imaging, categₛt2i, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, ComputingMilieux_MISCELLANEOUS, Imagerie cérébrale
Abstract

International audience

Published
2009

30. Novel role of UHRF1 in the epigenetic repression of the latent HIV-1

Author

Roxane Verdikt, Maryam Bendoumou, Sophie Bouchat, Lorena Nestola, Alexander O. Pasternak, Gilles Darcis, Véronique Avettand-Fenoel, Caroline Vanhulle, Amina Aït-Ammar, Marion Santangelo, Estelle Plant, Valentin Le Douce, Nadège Delacourt, Aurelija Cicilionytė, Coca Necsoi, Francis Corazza, Caroline Pereira Bittencourt Passaes, Christian Schwartz, Martin Bizet, François Fuks, Asier Sáez-Cirión, Christine Rouzioux, Stéphane De Wit, Ben Berkhout, Virginie Gautier, Olivier Rohr, Carine Van Lint, Université libre de Bruxelles (ULB), University of Amsterdam [Amsterdam] (UvA), Université de Liège, CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut Cochin (IC UM3 (UMR 8104 / U1016)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), University College Dublin [Dublin] (UCD), Institut Pasteur [Paris] (IP), HIV, Inflammation et persistance - HIV, Inflammation and Persistence, Institut Pasteur [Paris] (IP)-Université Paris Cité (UPCité), Université de Strasbourg (UNISTRA), CVL acknowledges funding from the Belgian National Fund for Scientific Research (F.R.S.-FNRS, Belgium), the « Fondation Roi Baudouin », the NEAT (European AIDS Treatment Network) program, the Internationale Brachet Stiftung, ViiV Healthcare, the Walloon Region (« Fonds de Maturation »), « Les Amis des Instituts Pasteur à Bruxelles, asbl », and the University of Brussels (Action de Recherche Concertée ULB grant) related to her work on HIV latency. The laboratory of CVL is part of the ULB-Cancer Research Center (U-CRC). RV was funded by an 'Aspirant' fellowship (F.R.S-FNRS), a fellowship from 'Les Amis des Instituts Pasteur à Bruxelles, asbl' and is a Belgian American Educational Foundation (BAEF) fellow and a scientific collaborator of the ULB. LN is supported by a 'PDR' grant from the F.R.S-FNRS. GD is a postdoctoral clinical master specialist for the F.R.S-FNRS. A A-A is a fellow of the 'Wallonie-Bruxelles International' Program and the Marie Skłodowska Curie COFUND action. EP is a fellow of the 'Télévie Program' (F.R.S-FNRS). MBD and MS are funded by FRIA fellowships (F.R.S.-FNRS). CVL is 'Directeur de Recherches' at the F.R.S-FNRS. Work in OR's laboratory was supported by grants from the French Agency for Research on AIDS and Viral Hepatitis (ANRS), the Sidaction and the 'Alsace contre le Cancer' Foundation. This work was supported by the European Union's Horizon 2020 research and innovation program under grant agreement No 691119-EU4HIVCURE-H2020-MSCA-RISE-2015. This work is supported by 1UM1AI164562-01, co-funded by National Heart, Lung and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, National Institute on Drug Abuse and the National Institute of Allergy and Infectious, We thank the members of the ANRS (French National Agency for Research on AIDS and Viral Hepatitis) RHIVIERA (Remission of HIV Era) Consortium for helpful discussions. We thank the HIV-1+ individuals for their willingness to participate in this study. We thank the nursing team of CHU Saint-Pierre Hospital (Elodie Goudeseune, Joëlle Cailleau and Annick Caestecker) who cared for the HIV+ individuals. We thank Jacqueline Pineau from the transfusion centre of Charleroi (Belgium) for providing blood from healthy donors. We thank Hilde Vereertbrugghen from Francis Corazza's laboratory for excellent technical assistance. We thank Motoko Unoki for her precious advice regarding UHRF1 RNA interference. We thank Mitia Duerinckx and Benoît Van Driessche for their support in the probabilistic and statistical analyses., European Project: 691119,H2020,H2020-MSCA-RISE-2015,EU4HIVCURE(2016), Saez-Cirion, Asier, Accelerating HIV Cure in Europe - EU4HIVCURE - - H20202016-02-01 - 2020-01-31 - 691119 - VALID, Medical Microbiology and Infection Prevention, AII - Infectious diseases, Service of Molecular Virology, Department of Molecular Biology (DBM), Université Libre de Bruxelles (ULB), Gosselies 6041, Belgium, Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Laboratory of Experimental Virology, Amsterdam 1105 AZ, the Netherland, Infectious Diseases Department, Liège University Hospital, Liège 4000, Belgium, Centre for Research in Infectious Diseases, University College Dublin, Dublin 4, Ireland, Service des Maladies Infectieuses, CHU St-Pierre, Université Libre de Bruxelles (ULB), Brussels 1000, Belgium, Laboratory of Immunology, IRISLab, CHU Brugmann, Université Libre de Bruxelles (ULB), Brussels 1020, Belgium, Dynamique des interactions hôte pathogène (DIHP), Laboratory of Cancer Epigenetics, Faculty of Medicine, ULB-Cancer Research Center (U-CRC), Université Libre de Bruxelles (ULB), Brussels 1070, Belgium, and AP-HP, Hôpital Necker-Enfants-Malades, Service de Microbiologie clinique, Paris 75015, France

Subjects
Ubiquitin-Protein Ligases, Clinical Sciences, HIV Infections, Epigenetic Repression, Decitabine, General Biochemistry, Genetics and Molecular Biology, Genetics, Humans, 2.2 Factors relating to the physical environment, 2.1 Biological and endogenous factors, Aetiology, UHRF1, [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Acquired Immunodeficiency Syndrome, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, General Medicine, DNA Methylation, Reactivation, Virus Latency, Infectious Diseases, Good Health and Well Being, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, HIV-1, CCAAT-Enhancer-Binding Proteins, Public Health and Health Services, HIV/AIDS, Epigenetics, HIV-1 latency, Infection, EGCG
Abstract

BackgroundThe multiplicity, heterogeneity, and dynamic nature of human immunodeficiency virus type-1 (HIV-1) latency mechanisms are reflected in the current lack of functional cure for HIV-1. Accordingly, all classes of latency-reversing agents (LRAs) have been reported to present variable ex vivo potencies. Here, we investigated the molecular mechanisms underlying the potency variability of one LRA: the DNA methylation inhibitor 5-aza-2'-deoxycytidine (5-AzadC).MethodsWe employed epigenetic interrogation methods (electrophoretic mobility shift assays, chromatin immunoprecipitation, Infinium array) in complementary HIV-1 infection models (latently-infected T-cell line models, primary CD4+ T-cell models and ex vivo cultures of PBMCs from HIV+ individuals). Extracellular staining of cell surface receptors and intracellular metabolic activity were measured in drug-treated cells. HIV-1 expression in reactivation studies was explored by combining the measures of capsid p24Gag protein, green fluorescence protein signal, intracellular and extracellular viral RNA and viral DNA.FindingsWe uncovered specific demethylation CpG signatures induced by 5-AzadC in the HIV-1 promoter. By analyzing the binding modalities to these CpG, we revealed the recruitment of the epigenetic integrator Ubiquitin-like with PHD and RING finger domain 1 (UHRF1) to the HIV-1 promoter. We showed that UHRF1 redundantly binds to the HIV-1 promoter with different binding modalities where DNA methylation was either non-essential, essential or enhancing UHRF1 binding. We further demonstrated the role of UHRF1 in the epigenetic repression of the latent viral promoter by a concerted control of DNA and histone methylations.InterpretationA better understanding of the molecular mechanisms of HIV-1 latency allows for the development of innovative antiviral strategies. As a proof-of-concept, we showed that pharmacological inhibition of UHRF1 in ex vivo HIV+ patient cell cultures resulted in potent viral reactivation from latency. Together, we identify UHRF1 as a novel actor in HIV-1 epigenetic silencing and highlight that it constitutes a new molecular target for HIV-1 cure strategies.FundingFunding was provided by the Belgian National Fund for Scientific Research (F.R.S.-FNRS, Belgium), the «Fondation Roi Baudouin», the NEAT (European AIDS Treatment Network) program, the Internationale Brachet Stiftung, ViiV Healthcare, the Télévie, the Walloon Region («Fonds de Maturation»), «Les Amis des Instituts Pasteur à Bruxelles, asbl», the University of Brussels (Action de Recherche Concertée ULB grant), the Marie Skodowska Curie COFUND action, the European Union's Horizon 2020 research and innovation program under grant agreement No 691119-EU4HIVCURE-H2020-MSCA-RISE-2015, the French Agency for Research on AIDS and Viral Hepatitis (ANRS), the Sidaction and the "Alsace contre le Cancer" Foundation. This work is supported by 1UM1AI164562-01, co-funded by National Heart, Lung and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, National Institute on Drug Abuse and the National Institute of Allergy and Infectious Diseases.

Published
2022

31. Mere end lugtesans - COVID-19 er associeret med svær påvirkning af lugtesansen, smagssansen og mundfølelsen

Author

Parma, Valentina, Ohla, Kathrin, Veldhuizen, Maria G, Niv, Masha Y, Kelly, Christine E, Bakke, Alyssa J, Cooper, Keiland W, Bouysset, Cédric, Pirastu, Nicola, Dibattista, Michele, Kaur, Rishemjit, Liuzza, Marco Tullio, Pepino, Marta Y, Schöpf, Veronika, Pereda-Loth, Veronica, Olsson, Shannon B, Gerkin, Richard C, Rohlfs Domínguez, Paloma, Albayay, Javier, Farruggia, Michael C, Bhutani, Surabhi, Fjaeldstad, Alexander W, Kumar, Ritesh, Menini, Anna, Bensafi, Moustafa, Sandell, Mari, Konstantinidis, Iordanis, Di Pizio, Antonella, Genovese, Federica, Öztürk, Lina, Thomas-Danguin, Thierry, Frasnelli, Johannes, Boesveldt, Sanne, Saatci, Özlem, Saraiva, Luis R, Lin, Cailu, Golebiowski, Jérôme, Hwang, Liang-Dar, Ozdener, Mehmet Hakan, Guàrdia, Maria Dolors, Laudamiel, Christophe, Ritchie, Marina, Havlícek, Jan, Pierron, Denis, Roura, Eugeni, Navarro, Marta, Nolden, Alissa A, Lim, Juyun, Whitcroft, Katherine L, Colquitt, Lauren R, Ferdenzi, Camille, Brindha, Evelyn V, Altundag, Aytug, Macchi, Alberto, Nunez-Parra, Alexia, Patel, Zara M, Fiorucci, Sébastien, Philpott, Carl M, Smith, Barry C, Lundström, Johan N, Mucignat, Carla, Parker, Jane K, van den Brink, Mirjam, Schmuker, Michael, Fischmeister, Florian Ph S, Heinbockel, Thomas, Shields, Vonnie D C, Faraji, Farhoud, Santamaría, Enrique, Fredborg, William E A, Morini, Gabriella, Olofsson, Jonas K, Jalessi, Maryam, Karni, Noam, D’Errico, Anna, Alizadeh, Rafieh, Pellegrino, Robert, Meyer, Pablo, Huart, Caroline, Chen, Ben, Soler, Graciela M, Alwashahi, Mohammed K, Welge-Lüssen, Antje, Freiherr, Jessica, de Groot, Jasper H B, Klein, Hadar, Okamoto, Masako, Singh, Preet Bano, Hsieh, Julien W, Abdulrahman, Olagunju, Dalton, Pamela, Yan, Carol H, Voznessenskaya, Vera V, Chen, Jingguo, Sell, Elizabeth A, Walsh-Messinger, Julie, Archer, Nicholas S, Koyama, Sachiko, Deary, Vincent, Roberts, S Craig, Yanık, Hüseyin, Albayrak, Samet, Nováková, Lenka Martinec, Croijmans, Ilja, Mazal, Patricia Portillo, Moein, Shima T, Margulis, Eitan, Mignot, Coralie, Mariño, Sajidxa, Georgiev, Dejan, Kaushik, Pavan K, Malnic, Bettina, Wang, Hong, Seyed-Allaei, Shima, Yoluk, Nur, Razzaghi-Asl, Sara, Justice, Jeb M, Restrepo, Diego, Reed, Danielle R, Hummel, Thomas, Munger, Steven D, Hayes, John E, Indústries Alimentàries, Qualitat i Tecnologia Alimentària, Tecnologia Alimentària, Temple University [Philadelphia], Pennsylvania Commonwealth System of Higher Education (PCSHE), Forschungszentrum Jülich GmbH | Centre de recherche de Juliers, Helmholtz-Gemeinschaft = Helmholtz Association, Mersin University, The Hebrew University of Jerusalem (HUJ), AbScent, Pennsylvania State University (Penn State), Penn State System, University of California [Irvine] (UC Irvine), University of California (UC), Université Côte d'Azur (UCA), University of Edinburgh, Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro (UNIBA), Central Scientific Instruments Organisation (CSIR), Università degli Studi 'Magna Graecia' di Catanzaro = University of Catanzaro (UMG), University of Illinois at Urbana-Champaign [Urbana], University of Illinois System, Medizinische Universität Wien = Medical University of Vienna, Groupement scientifique de Biologie et de Medecine Spatiale (GSBMS), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National d'Études Spatiales [Toulouse] (CNES), Tata Institute for Fundamental Research (TIFR), Arizona State University [Tempe] (ASU), Universidad de Extremadura - University of Extremadura (UEX), Università degli Studi di Padova = University of Padua (Unipd), Yale School of Medicine [New Haven, Connecticut] (YSM), San Diego State University (SDSU), Aarhus University [Aarhus], University of Hertfordshire [Hatfield] (UH), Scuola Internazionale Superiore di Studi Avanzati / International School for Advanced Studies (SISSA / ISAS), Neurosciences Sensorielles Comportement Cognition, Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Helsingin yliopisto = Helsingfors universitet = University of Helsinki, University of Turku, Aristotle University of Thessaloniki, Leibniz-Institute for Food Systems Biology at the Technical University of Munich, Monell Chemical Senses Center, Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Bourgogne Franche-Comté [COMUE] (UBFC), Université de Montréal (UdeM), Wageningen University and Research Centre (WUR), Medical Science University, Sidra Medicine [Doha, Qatar], Institut de Chimie de Nice (ICN), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), University of Southern Queensland (USQ), Institut de Recerca i Tecnologia Agroalimentàries = Institute of Agrifood Research and Technology (IRTA), DreamAir Llc, Charles University [Prague] (CU), Anthropologie Moléculaire et Imagerie de Synthèse (AMIS), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), University of Massachusetts System (UMASS), Oregon State University (OSU), Ear Institute, UCL, Lyon Neuroscience Research center, Karunya University, Biruni University, Assi Sette Llaghi Varese, Stanford School of Medicine [Stanford], Stanford Medicine, Stanford University-Stanford University, University of East Anglia [Norwich] (UEA), California Department of Food and Agriculture (CDFA), Unité mixte de recherche interactions plantes-microorganismes, Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Maastricht University [Maastricht], Institute for Biology - Neurobiology, Freie Universität Berlin, Karl-Franzens-Universität Graz, Howard University College of Medicine, Towson University, University of California [San Diego] (UC San Diego), Proteomics, Center for Applied Medical Research (CIMA), Stockholm University, University of Gastronomic Sciences, Iran University of Medical Sciences, Goethe Universität Frankfurt, University of Tennessee, IBM T.J. Watson Research Center, Université libre de Bruxelles (ULB), Guangzhou Medical University, Buenos Aires University and GEOG (Grupo de Estudio de Olfato y Gusto), Sultan Qaboos University (SQU), Federal University of Technology of Akure (FUTA), A.N. Severtsov Institute of Ecology and Evolution, Russian Academy of Sciences [Moscow] (RAS), Hospital of Xi'an Jiaotong University, University of Pennsylvania, University of Dayton, CSIRO Agriculture and Food (CSIRO), Indiana University [Bloomington], Indiana University System, University of Northumbria at Newcastle [United Kingdom], University of Stirling, Middle East Technical University [Ankara] (METU), Utrecht University [Utrecht], Instituto Universitario del Hospital Italiano [Buenos Aires, Argentina], Institute for Research in Fundamental Sciences [Tehran] (IPM), Hebrew University of Jerusalem, Technische Universität Dresden = Dresden University of Technology (TU Dresden), Terrazas del Club Hipico, University Medical Centre Ljubljana [Ljubljana, Slovenia] (UMCL), Tata Institute of Fundamental Research [Bangalore], Universidade de São Paulo = University of São Paulo (USP), University of Florida [Gainesville] (UF), University of Colorado Anschutz [Aurora], Center for Smell and Taste, Department of Food Science, Pennsylvania State University., Julien, Sabine, Tıp Fakültesi, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service d'oto-rhino-laryngologie, Department of Food and Nutrition, Senses and Food, Research Center Jülich, University of California [Irvine] (UCI), University of California, Università degli studi di Bari Aldo Moro (UNIBA), Università degli Studi 'Magna Graecia' di Catanzaro [Catanzaro, Italie] (UMG), University of Extremadura, University of Padova, Yale University School of Medicine, Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, University of Helsinki, Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Institute of Agrifood Research and Technology (IRTA), Universita degli Studi di Padova, Centre National de la Recherche Scientifique (CNRS)-Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Karl-Franzens-Universität [Graz, Autriche], University of California San Diego Health, University of Brussels, University of Pennsylvania [Philadelphia], Tata Institute of Fundamental Research, University of São Paulo (USP), UCL - SSS/IONS - Institute of NeuroScience, FSE Campus Venlo, and RS: FSE UCV

Subjects
Male, Taste, Physiology, Smagstab, Audiology, AcademicSubjects/SCI01180, Settore BIO/09 - Fisiologia, Behavioral Neuroscience, chemistry.chemical_compound, Olfaction Disorders, Taste Disorders, 0302 clinical medicine, RATINGS, Hyposmia, Surveys and Questionnaires, CHEMOSENSITIVITY, [SDV.IDA]Life Sciences [q-bio]/Food engineering, Viral, PALADAR, 030223 otorhinolaryngology, Sensory Science and Eating Behaviour, media_common, TASTE, US NATIONAL-HEALTH, [SDV.IDA] Life Sciences [q-bio]/Food engineering, Middle Aged, Biological Sciences, 16. Peace & justice, Sensory Systems, 3. Good health, Smell, GCCR Group Author, ddc:540, Smell loss, Female, Original Article, medicine.symptom, Corrigendum, Coronavirus Infections, olfaction, Adult, somatosensation, medicine.medical_specialty, 663/664, Coronavirus disease 2019 (COVID-19), OLFACTORY DISORDERS, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), media_common.quotation_subject, Pneumonia, Viral, head and neck surgery, Aged, Betacoronavirus, COVID-19, Humans, Pandemics, SARS-CoV-2, Self Report, Somatosensory Disorders, Young Adult, Anosmia, Sensory system, Olfaction, 03 medical and health sciences, Chemesthesis, Physiology (medical), Perception, medicine, Neurology & Neurosurgery, Behaviour Change and Well-being, business.industry, R-PACKAGE, 3112 Neurosciences, Pneumonia, Parosmia, COMPONENT, Smagssans, [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, Sensoriek en eetgedrag, chemistry, Lugtetab, business, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, 030217 neurology & neurosurgery, Lugtesans
Abstract

Correction: Chemical Senses, Volume 46, 2021, bjab050, https://doi.org/10.1093/chemse/bjab050 Published: 08 December 2021 Recent anecdotal and scientific reports have provided evidence of a link between COVID-19 and chemosensory impairments, such as anosmia. However, these reports have downplayed or failed to distinguish potential effects on taste, ignored chemesthesis, and generally lacked quantitative measurements. Here, we report the development, implementation, and initial results of a multilingual, international questionnaire to assess self-reported quantity and quality of perception in 3 distinct chemosensory modalities (smell, taste, and chemesthesis) before and during COVID-19. In the first 11 days after questionnaire launch, 4039 participants (2913 women, 1118 men, and 8 others, aged 19-79) reported a COVID-19 diagnosis either via laboratory tests or clinical assessment. Importantly, smell, taste, and chemesthetic function were each significantly reduced compared to their status before the disease. Difference scores (maximum possible change +/- 100) revealed a mean reduction of smell (-79.7 +/- 28.7, mean +/- standard deviation), taste (-69.0 +/- 32.6), and chemesthetic (-37.3 +/- 36.2) function during COVID-19. Qualitative changes in olfactory ability (parosmia and phantosmia) were relatively rare and correlated with smell loss. Importantly, perceived nasal obstruction did not account for smell loss. Furthermore, chemosensory impairments were similar between participants in the laboratory test and clinical assessment groups. These results show that COVID-19-associated chemosensory impairment is not limited to smell but also affects taste and chemesthesis.The multimodal impact of COVID-19 and the lack of perceived nasal obstruction suggest that severe acute respiratory syndrome coronavirus strain 2 (SARS-CoV-2) infection may disrupt sensory-neural mechanisms.

Published
2020

32. Plants as Machines: History, Philosophy and Practical Consequences of an Idea

Author

Sophie Gerber, Quentin Hiernaux, Biodiversité, Gènes & Communautés (BioGeCo), Université de Bordeaux (UB)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), École des hautes études en sciences sociales (EHESS), and University of Brussels

Subjects
Ethics, History, philosophy, biology, Machine, [SHS.PHIL]Humanities and Social Sciences/Philosophy, Environmental Chemistry, [SDV.BV]Life Sciences [q-bio]/Vegetal Biology, plant, Agriculture, Agricultural and Biological Sciences (miscellaneous), General Environmental Science
Abstract

International audience; This paper elucidates the philosophical origins of the conception of plants as machines and analyses the contemporary technical and ethical consequences of that thinking. First, we explain the historical relationship between the explicit animal machine thesis of Descartes and the implicit plant machine thesis of today. Our hypothesis is that, although it is rarely discussed, the plant machine thesis remains influential. We define the philosophical criteria for both a moderate and radical interpretation of the thesis. Then, assessing the compatibility of current botanical knowledge with both interpretations, we find that neither withstands scrutiny. We trace how biological and agricultural sciences have historically relied upon thinking of plants as machines and how they continue to do so today through rhetoric centred on breeding, biotechnology, and production. We discuss some of the most important legal and ethical consequences of obscuring the vitality of plants. Finally, we explore less reductive and destructive ways of thinking about, and using, plants.; Les plantes sont régulièrement identifiées à des machines. Quelles sont les origines philosophiques de cette représentation du monde végétal ? Quelles sont les conséquences techniques et éthiques de cette conception ? L'idée trouve ses racines dans l'animal-machine de Descartes mais la thèse de la plante-machine reste aujourd'hui largement implicite. Nous faisons l'hypothèse que, bien qu'elle soit rarement discutée, cette thèse reste influente actuellement. Nous analysons comment les sciences biologiques et agricoles se sont historiquement appuyées sur la pensée des plantes vues comme des machines et comment elles continuent à le faire aujourd'hui, autour de la sélection végétale, de la production agricole et des biotechnologies. Nous discutons des conséquences juridiques et éthiques les plus préoccupantes de l’occultation du caractère vivant des plantes. Enfin, nous explorons des voies moins réductrices et destructrices de penser aux plantes et de vivre avec elles.

Published
2022

33. Paradiseo: From a Modular Framework for Evolutionary Computation to the Automated Design of Metaheuristics

Author

Dreo, Johann, Liefooghe, Arnaud, Verel, Sébastien, Schoenauer, Marc, Merelo, Juan, Quemy, Alexandre, Bouvier, Benjamin, Gmys, Jan, Biologie systémique - Systems Biology, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Optimisation de grande taille et calcul large échelle (BONUS), Inria Lille - Nord Europe, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Informatique Signal et Image de la Côte d'Opale (LISIC), Université du Littoral Côte d'Opale (ULCO), TAckling the Underspecified (TAU), Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire Interdisciplinaire des Sciences du Numérique (LISN), Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-CentraleSupélec-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Universidad de Granada = University of Granada (UGR), Poznan University of Technology (PUT), Chercheur indépendant, During 22 years, Paradiseo has been developed by more than 50 people, with the support of the following institutions: Inria, University of Lille, University of the Littoral Opal Coast, Thales, Ecole Polytechnique, University of Granada, Vrije Universiteit Amsterdam, Leiden University, French National Centre for Scientific Research (CNRS), French National Agency for Research (ANR), Fritz Haber Institute of the Max Planck Society, Center for Free-Electron Laser Science, University of Angers, French National Institute of Applied Sciences, Free University of Brussels, Pasteur Institute., ACM Sigevo, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Université de Lille-Centrale Lille-Centre National de la Recherche Scientifique (CNRS)-Université de Lille-Centrale Lille-Centre National de la Recherche Scientifique (CNRS), CentraleSupélec-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-CentraleSupélec-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), and University of Granada [Granada]

Subjects
Software Framework, Automated Algorithm Design, Metaheuristics, Evolutionary Computation, [INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI], [INFO.INFO-MS]Computer Science [cs]/Mathematical Software [cs.MS]
Abstract

International audience; The success of metaheuristic optimization methods has led to the development of a large variety of algorithm paradigms. However, no algorithm clearly dominates all its competitors on all problems. Instead, the underlying variety of landscapes of optimization problems calls for a variety of algorithms to solve them efficiently. It is thus of prior importance to have access to mature and flexible software frameworks which allow for an efficient exploration of the algorithm design space. Such frameworks should be flexible enough to accommodate any kind of metaheuristics, and open enough to connect with higherlevel optimization, monitoring and evaluation softwares. This article summarizes the features of the Paradiseo framework, a comprehensive C++ free software which targets the development of modular metaheuristics. Paradiseo provides a highly modular architecture, a large set of components, speed of execution and automated algorithm design features, which are key to modern approaches to metaheuristics development.

Published
2021

34. Data Protection and the EPPO

Author

Vagelis Papakonstantinou, Paul De Hert, TILT, Brussels Interdisciplinary Research centre on Migration and Minorities, University of Brussels - European Criminal Law, Metajuridica, Law Science Technology and Society, and Fundamental rights centre

Subjects
History, Polymers and Plastics, Order (business), Political science, Law, media_common.cataloged_instance, Data Protection Act 1998, Business and International Management, European union, European Public Prosecutor, Industrial and Manufacturing Engineering, Data Protection Directive, media_common
Abstract

The European Public Prosecutor’s Office (the ‘EPPO’) necessarily processes personal data in order to fulfil its mission; As such, it falls squarely within the European Union (EU) data protection regulatory landscape. However, because the EU data protection regulatory landscape itself is currently found at a crossroads, an analysis of the EPPO data protection model may be twofold: First, placing it within the proper cross-organization dialogue currently taking place on the future regulatory model of personal data processing for law enforcement purposes carried out at EU level. Second, at an EPPO-specific level, whereby the actual data protection regime afforded to it may be assessed. This article purports to elaborate upon the above two data protection dimensions of EPPO personal data processing activities: It presents considerations and policy options during the lawmaking period that resulted in the establishment of the EPPO, it analyses the data protection regime ultimately awarded to it and attempts to, critically, place the EPPO data protection model within its proper operational and legislative environment.

Published
2019

35. INTREPID D1.4 Data Innovation IPR Management Plan

Author

Francisco Javier López Guzmán, Istvan Mate Borocz, Paul de Hert, Thibaud Chemin, Tiphaine Guyomard, Metajuridica, Faculty of Law and Criminology, Law Science Technology and Society, Brussels Interdisciplinary Research centre on Migration and Minorities, University of Brussels - European Criminal Law, and Fundamental rights centre

Published
2021

36. Castaño avoids a clash between the ECtHR and the CJEU, but erodes Soering. Thinking human rights transnationally

Author

Paul De Hert, Sibel Top, Brussels Interdisciplinary Research centre on Migration and Minorities, Metajuridica, Faculty of Law and Criminology, Fundamental rights centre, and University of Brussels - European Criminal Law

Subjects
Balance (metaphysics), Human rights, Strasbourg and Luxembourg dialogue, media_common.quotation_subject, Political science, human rights and judicial cooperation, policy change CJEU and ECtHR, Obligation, human rights, Extradition, Law and economics, media_common
Abstract

This article examines the changing balance established by the European Court of Human Rights (ECtHR) between human rights filters to extradition and the obligation to cooperate and how this shift of rationale brought the Court closer to the position of the Court of Justice of the European Union (CJEU) in that respect. The article argues that the ECtHR initially adopted a position whereby it prioritised human rights concerns over extraditions, but that it later nuanced that approach by establishing, in some cases, an obligation to cooperate to ensure proper respect of human rights. This refinement of its position brought the ECtHR closer to the approach adopted by the CJEU that traditionally put the obligation to cooperate above human rights concerns. In recent years, however, the CJEU also backtracked to some extent from its uncompromising attitude on the obligation to cooperate, which enabled a convergence of the rationales of the two Courts. Although this alignment of the Courts was necessary to mitigate the conflicting obligations of European Union Member States towards both Courts, this article warns against the danger of making too many human rights concessions to cooperation in criminal matters.

Published
2021

37. Making sense of missense variants in TTN-related congenital myopathies

Author

Anna Sarkozy, Erik-Jan Kamsteeg, Mark Pfuhl, Nicol C. Voermans, Martin Rees, Corrie E. Erasmus, Hülya-Sevcan Daimagüler, Steven A. Moore, Rahul Phadke, Mark R. Holt, Rolf Schröder, Istvan Bodi, Carla Grosmann, Sebahattin Cirak, E. Matthews, Ay Lin Kho, Peter Van den Bergh, Christian Thiel, Shane McKee, Joel Victor Fluss, Roksana Nikoopour, Charu Deshpande, Jens Reimann, Emily C. Oates, Maria Elena Farrugia, Özkan Özdemir, Isabelle Richard, Cristina Domínguez-González, Chaminda Konersman, Ekkehard Wilichowski, Birgit Brandmeier, Atsushi Fukuzawa, Ana Ferreiro, Heinz Jungbluth, Ros Quinlivan, Sandya Tirupathi, Mathias Gautel, Gabriele Dekomien, Cheryl Longman, Miguel A Fernandez-Garcia, Francesco Muntoni, Michael G. Hanna, Elizabeth Wraige, Elke Hobbiebrunken, Sarah Grover, UCL - SSS/IONS - Institute of NeuroScience, UCL - (SLuc) Service de neurologie, UCL - (SLuc) Centre de référence neuromusculaire, King‘s College London, Evelina London Children's Hospital, Guy's Hospital [London], University of Cologne, Children’s University Hospital of Geneva [Switzerland], Queen Elizabeth University Hospital (Glasgow), National Hospital for Neurology and Neurosurgery [London, UK], Great Ormond Street Hospital for Children [London] (GOSH), University College of London [London] (UCL), University of New South Wales [Sydney] (UNSW), Westmead Hospital [Sydney], University Hospital Erlangen [Germany], Universitätsklinikum Erlangen [Erlangen], University of Bonn Medical Centre [Bonn], Radboud university [Nijmegen], Rady Children's Hospital, Belfast City Hospital, Royal Belfast Hospital for Sick Children, University of Iowa [Iowa City], University of Göttingen - Georg-August-Universität Göttingen, Approches génétiques intégrées et nouvelles thérapies pour les maladies rares (INTEGRARE), Université d'Évry-Val-d'Essonne (UEVE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Généthon, Généthon, Saint-Luc University Hospital [Brussels, Belgium], Hospital Universitario 12 de Octubre [Madrid], Université de Paris (UP), Institut de Myologie, Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Association française contre les myopathies (AFM-Téléthon)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), CHU Charles Foix [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), King's College Hospital (KCH), MRC Centre for Neuromuscular Diseases [London, UK], University Hospital Erlangen = Uniklinikum Erlangen, Radboud University [Nijmegen], Radboud University Medical Center [Nijmegen], Gillette Children's Specialty Healthcare [St Paul], Georg-August-University = Georg-August-Universität Göttingen, Ruhr-Universität Bochum [Bochum], Université Paris Cité (UPCité), Unité de Biologie Fonctionnelle et Adaptative (BFA (UMR_8251 / U1133)), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)

Subjects
Adult, Male, 0301 basic medicine, Weakness, Adolescent, Myotonia Congenita, Mutation, Missense, Other Research Donders Center for Medical Neuroscience [Radboudumc 0], Extraocular muscles, Sensory disorders Donders Center for Medical Neuroscience [Radboudumc 12], Pathology and Forensic Medicine, Young Adult, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Humans, Medicine, Missense mutation, Connectin, Child, Myopathy, Aged, Muscle contracture, Genetics, Phenocopy, Original Paper, biology, business.industry, Infant, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, Middle Aged, Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3], medicine.disease, Congenital myopathy, 3. Good health, 030104 developmental biology, medicine.anatomical_structure, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, Child, Preschool, biology.protein, Female, Titin, Neurology (clinical), medicine.symptom, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, 030217 neurology & neurosurgery
Abstract

Mutations in the sarcomeric protein titin, encoded byTTN, are emerging as a common cause of myopathies. The diagnosis of aTTN-related myopathy is, however, often not straightforward due to clinico-pathological overlap with other myopathies and the prevalence ofTTNvariants in control populations. Here, we present a combined clinico-pathological, genetic and biophysical approach to the diagnosis ofTTN-related myopathies and the pathogenicity ascertainment ofTTNmissense variants. We identified 30 patients with a primaryTTN-related congenital myopathy (CM) and two truncating variants, or one truncating and one missenseTTNvariant, or homozygous for oneTTNmissense variant. We found that TTN-related myopathies show considerable overlap with other myopathies but are strongly suggested by a combination of certain clinico-pathological features. Presentation was typically at birth with the clinical course characterized by variable progression of weakness, contractures, scoliosis and respiratory symptoms but sparing of extraocular muscles. Cardiac involvement depended on the variant position. Our biophysical analyses demonstrated that missense mutations associated with CMs are strongly destabilizing and exert their effect when expressed on a truncating background or in homozygosity. We hypothesise that destabilizingTTNmissense mutations phenocopy truncating variants and are a key pathogenic feature of recessive titinopathies that might be amenable to therapeutic intervention.

Published
2021

45. The dawn of an open exploration era: Emergent principles and practices of open science and innovation of university research teams in a digital world

Author

Vicente-Saez, Ruben, Gustafsson, Robin, Van den Brande, Lieve, Department of Industrial Engineering and Management, Free University of Brussels, Aalto-yliopisto, and Aalto University

Subjects
Open innovation, Universities, Open innovation policy, Research teams, Openness, Open science, Open exploration, Governance of research and innovation
Abstract

Principles and practices of open science at universities are evolving. Increasing use and application of digital technologies and platforms in research and innovation are pushing universities to take up and develop new visions and principles for how research and innovation are performed. These open science policies and practices (i.e. open data sharing, open access publishing, open repositories, open physical labs, participatory design, and transdisciplinary research platforms) are expanding the ethos of science and innovation at universities. These new principles and practices of open science at universities are also triggering novel open innovation practices by university research teams. Open science and innovation practices hold great potential for accelerating the learning and creation of new knowledge, speeding up the research and innovation process for finding solutions for grand societal challenges, and nurturing the growth of highly innovative and entrepreneurial people. The purpose of this study was to identify emergent principles, practices, and underlying mechanisms of open science and innovation developed and encountered by research teams at universities. The results of this study provide directions for how to advance openness in science at universities and illustrate how openness in innovation is being remodelled by open science practices. Based on our findings, we propose an open exploration policy and a governance model of open science and innovation at universities in the digital world, which aspire to create increased societal value.

Published
2020

48. The fundamental rights impact on those living in poverty or in a precarious situation of the measures taken to reduce the spread of Covid-19

Author

Weatherburn, Amy, De Hert, Paul, Gutwirth, Serge, Metajuridica, Brussels Interdisciplinary Research centre on Migration and Minorities, Fundamental rights centre, University of Brussels - European Criminal Law, Law Science Technology and Society, and Brussels Centre for Urban Studies

Abstract

The impact of anti-Covid-19 measures on those living in poverty and in a precarious situation and the potential increasing existing inequalities has been raised by Unia (the interfederal center for equal opportunities)3 and the Network Against Poverty who’s successful call to arms4 has seen the announcement on 8 April 2020 of an Federal Taskforce for Vulnerable Groups.5 This taskforce will investigate the impact of Covid-19 measures on vulnerable persons and those living in a precarious situation, we strongly welcome this next step in the Federal response to the corona crisis and encourage that the following considerations are taken into account in order to reduce the risk of further marginalisation and inequality.

Published
2020

49. Pain Neuroscience Education and Physical Therapeutic Exercise for Patients with Chronic Spinal Pain in Spanish Physiotherapy Primary Care: A Pragmatic Randomized Controlled Trial

Author

Enrique Lluch-Girbés, Federico Montero-Cuadrado, Antonio Cuesta-Vargas, Agustín Mayo-Iscar, María Carmen Coca-López, Miguel Angel Galan-Martin, [Galan-Martin,MA, Montero-Cuadrado,F] Unit for Active Coping Strategies for Pain in Primary Care, East-Valladolid Primary Care Management, Castilla and León Public Health System (Sacyl), Valladolid, Spain. [Galan-Martin,MA] Doctoral Program of Research in Health Sciences, University of Valladolid, Valladolid, Spain. [Lluch-Girbes,E] Department of Physical Therapy, University of Valencia, Valencia, Spain. [Lluch-Girbes,E] Pain in Motion International Research Group, Brussels, Belgium. [Lluch-Girbes,E] Department of Human Physiology and Rehabilitation Sciences, Faculty of Physiotherapy, Vrije University Brussels, Brussels, Belgium. [Coca-López,MC] Castilla and León Regional Centre of Sports Medicine, (Sacyl), Valladolid, Spain. [Mayo-Iscar,A] Department of Statistics and Operational Research and IMUVA, University of Valladolid, Valladolid, Spain. [Cuesta-Vargas,A] Department of Physiotherapy, Faculty of Heath Sciences, University of Malaga, Málaga, Spain. [Cuesta-Vargas,A] Institute of Biomedical Research in Malaga. IBIMA, Málaga, Spain. [Cuesta-Vargas,A] School of Clinical Science, Faculty of Health Science, Queensland University Technology, Brisbane, QLD, Australia., This research was funded by the Regional Health Management of Castilla and León and the Professional College of Physiotherapists of Castilla and León. The funds were obtained in competitive calls. Mayo-Iscar was partially supported by the Spanish Ministry of Economy and Competitiveness, grant MTM2017–86061-C2–1-P, and by the Education Department of Castilla and León Government and FEDER, grant VA005P17 and VA002G18. The funding bodies were not involved in the design of the study, collection, analysis, and interpretation of data, and in writing the manuscript., Pain in Motion, and Physiotherapy, Human Physiology and Anatomy

Subjects
Health Care::Health Services Administration::Patient Care Management::Delivery of Health Care [Medical Subject Headings], lcsh:Medicine, Chronic pain, Ensayo clínico controlado aleatorio, law.invention, Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Nervous System Physiological Phenomena::Central Nervous System Sensitization [Medical Subject Headings], 0302 clinical medicine, Randomized controlled trial, law, physical exercise, Neuroscience education, Health care, Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Musculoskeletal Physiological Phenomena::Musculoskeletal Physiological Processes::Movement::Motor Activity [Medical Subject Headings], 030212 general & internal medicine, Health Care::Population Characteristics::Health::Mental Health [Medical Subject Headings], education.field_of_study, Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Neurologic Manifestations::Pain::Chronic Pain [Medical Subject Headings], Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Nervous System Physiological Phenomena::Nervous System Physiological Processes::Sensation::Pain::Pain Threshold [Medical Subject Headings], General Medicine, Primary care, Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Personal Satisfaction [Medical Subject Headings], Ejercicio físico, Health Care::Health Services Administration::Patient Care Management::Comprehensive Health Care::Primary Health Care [Medical Subject Headings], chronic pain, chronic spinal pain, medicine.medical_specialty, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Methods::Research Design::Control Groups [Medical Subject Headings], Population, Chronic spinal pain, Physical exercise, Article, Educación neurocientífica, 03 medical and health sciences, primary care, Quality of life (healthcare), medicine, Humanities::Humanities::Philosophy::Life::Quality of Life [Medical Subject Headings], education, pain neuroscience education, Pain neuroscience education, business.industry, Diseases::Musculoskeletal Diseases::Muscular Diseases::Musculoskeletal Pain [Medical Subject Headings], Public health, lcsh:R, Dolor crónico, Atención primaria, medicine.disease, Clinical trial, randomized controlled trial, Physical therapy, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination::Neurologic Examination::Pain Measurement [Medical Subject Headings], business, Neuroscience, 030217 neurology & neurosurgery
Abstract

Producción Científica, Chronic musculoskeletal pain affects more than 20% of the population, leading to high health care overload and huge spending. The prevalence is increasing and negatively affects both physical and mental health, being one of the leading causes of disability. The most common location is the spine. Most treatments used in the Public Health Services are passive (pharmacological and invasive) and do not comply with current clinical guidelines, which recommend treating pain in primary care (PC) with education and exercise as the first-line treatments. A randomized multicentre clinical trial has been carried out in 12 PC centres. The experimental group (EG) conducted a program of pain neuroscience education (6 sessions, 10 h) and group physical exercise with playful, dual-tasking, and socialization-promoting components (18 sessions in 6 weeks, 18 h), and the control group performed the usual physiotherapy care performed in PC. The experimental treatment improved quality of life (d = 1.8 in physical component summary), catastrophism (d = 1.7), kinesiophobia (d = 1.8), central sensitization (d = 1.4), disability (d = 1.4), pain intensity (d = 3.3), and pressure pain thresholds (d = 2). Differences between the groups (p < 0.001) were clinically relevant in favour of the EG. Improvements post-intervention (week 11) were maintained at six months. The experimental treatment generates high levels of satisfaction., Ministerio de Economía, Industria y Competitividad (grant MTM2017–86061-C2–1-P), Junta de Castilla y León - Fondo Europeo de Desarrollo Regional (grants VA005P17 and VA002G18)

Published
2020

Catalog

Books, media, physical & digital resources
See catalog results