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2. Egg Intervention During Pregnancy in Indonesia (PRECODE)

Author

London School of Hygiene and Tropical Medicine, University of Aberdeen, University of Brighton, University College, London, Royal Veterinary College, Birkbeck, University of London, The International Livestock Research Institute (ILRI), Cheikh Anta Diop University, Senegal, National Institute of Nutrition, India, International Centre for Research in Agroforestry, Science Made Simple, Liverpool School of Tropical Medicine, International Initiative for Impact Evaluation, Digital Green Foundation, SOAS, University of London, University of Sheffield, and Dr.Umi Fahmida, Senior Researcher

Published
2024

3. Cognitive Rehabilitation for People With Cognitive Covid19

Author

Bangor University, St George's University Hospitals NHS Foundation Trust, University of Brighton, University Hospital Southampton NHS Foundation Trust, and Greater Manchester Mental Health NHS Foundation Trust

Published
2024

4. Safety and Tolerability of Yaq-001 in Patients With Non-Alcoholic Steatohepatitis

Author

University College, London, Servicio Madrileño de Salud, Madrid, Spain, Hospital Universitari Vall d'Hebron Research Institute, Azienda Ospedaliera di Padova, IRCCS Azienda Ospedaliero-Universitaria di Bologna, University of Bern, Assistance Publique - Hôpitaux de Paris, University of Lisbon, Alpha Bioresearch S.L., Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Brighton, and A2F Associates Limited

Published
2022

7. Safety and Tolerability of Yaq-001 in Patients With Cirrhosis

Author

University College, London, University of Brighton, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Azienda Ospedaliera di Padova, Hospital Universitari Vall d'Hebron Research Institute, IRCCS Azienda Ospedaliero-Universitaria di Bologna, University of Lisbon, Servicio Madrileño de Salud, Madrid, Spain, University of Bern, Assistance Publique - Hôpitaux de Paris, A2F Associates Limited, and Alpha Bioresearch S.L.

Published
2020

10. Validation Study of mHealth Technology in HIV to Improve Empowerment and Healthcare Utilisation: Research and Innovation to Generate Evidence for Personalised Care (EmERGE) (EMERGE)

Author

Brighton and Sussex University Hospitals NHS Trust, Instituut Voor Tropische Geneeskunde (ITM), Antwerp, Belgium., Klinika za infektivne bolesti (KIB), Zagreb, Croatia, Centro Hospitalar de Lisboa Central, Fundacion Clinic per a la Recerca Biomédica, University of Brighton, Podmedics, ( POD), Northwood, United Kingdom, Universidad Politecnica de Madrid, National Prospective Monitoring System HIV Health-economics Collaboration, (NPMS), Richmond, United Kingdom, European Aids Treatment Group (EATG), Brussels, Belgium, mHealth Futures LTD, Brighton, United Kingdom, and Agathe LEON, Dr

Published
2017

12. The blue carbon of southern southwest Atlantic salt marshes and their biotic and abiotic drivers

Author

Consejo Federal de Ciencia y Tecnología (Argentina), Fondo Nacional de Desarrollo Científico y Tecnológico (Chile), Universidad Nacional de Mar del Plata, Department of Commerce (US), Mississippi State University, European Commission, University of Brighton, Agencia Estatal de Investigación (España), Ministerio de Ciencia e Innovación (España), Martinetto, Paulina, Alberti, Juan, Becherucci, María Eugenia, Cebrián, Just, Iribarne. Óscar, Marbà, Núria, Montemayor, Diana, Sparks, Eric, Ward, Raymond, Consejo Federal de Ciencia y Tecnología (Argentina), Fondo Nacional de Desarrollo Científico y Tecnológico (Chile), Universidad Nacional de Mar del Plata, Department of Commerce (US), Mississippi State University, European Commission, University of Brighton, Agencia Estatal de Investigación (España), Ministerio de Ciencia e Innovación (España), Martinetto, Paulina, Alberti, Juan, Becherucci, María Eugenia, Cebrián, Just, Iribarne. Óscar, Marbà, Núria, Montemayor, Diana, Sparks, Eric, and Ward, Raymond

Abstract

Coastal vegetated ecosystems are acknowledged for their capacity to sequester organic carbon (OC), known as blue C. Yet, blue C global accounting is incomplete, with major gaps in southern hemisphere data. It also shows a large variability suggesting that the interaction between environmental and biological drivers is important at the local scale. In southwest Atlantic salt marshes, to account for the space occupied by crab burrows, it is key to avoid overestimates. Here we found that southern southwest Atlantic salt marshes store on average 42.43 (SE = 27.56) Mg OC·ha−1 (40.74 (SE = 2.7) in belowground) and bury in average 47.62 g OC·m−2·yr−1 (ranging from 7.38 to 204.21). Accretion rates, granulometry, plant species and burrowing crabs were identified as the main factors in determining belowground OC stocks. These data lead to an updated global estimation for stocks in salt marshes of 185.89 Mg OC·ha−1 (n = 743; SE = 4.92) and a C burial rate of 199.61 g OC·m−2·yr−1 (n = 193; SE = 16.04), which are lower than previous estimates.

Published
2023

14. Facebook as a Digital Diplomacy Tool: Case of Kazakhstan

Author

6th European Conference on Social Media (13-14 June 2019: University of Brighton), Kazbek, Botakoz, Almash, Aisulu, 6th European Conference on Social Media (13-14 June 2019: University of Brighton), Kazbek, Botakoz, and Almash, Aisulu

Abstract

info:eu-repo/semantics/nonPublished

Published
2019

16. Identification of a millisecond isomeric state in Cd81129 via the detection of internal conversion and Compton electrons

Author

Taprogge, J.(Instituto de Estructura de la Materia, CSIC, Madrid, E-28006, Spain), Jungclaus, A.(Instituto de Estructura de la Materia, CSIC, Madrid, E-28006, Spain), Grawe, H.(GSI Helmholtzzentrum für Schwerionenforschung GmbH, Darmstadt, 64291, Germany), Nishimura, S.(RIKEN Nishina Center, RIKEN, 2-1 Hirosawa, Wako-shi, Saitama, 351-0198, Japan), Xu, Z.Y.(RIKEN Nishina Center, RIKEN, 2-1 Hirosawa, Wako-shi, Saitama, 351-0198, Japan), Doornenbal, P.(RIKEN Nishina Center, RIKEN, 2-1 Hirosawa, Wako-shi, Saitama, 351-0198, Japan), Lorusso, G.(RIKEN Nishina Center, RIKEN, 2-1 Hirosawa, Wako-shi, Saitama, 351-0198, Japan), Nácher, E.(Instituto de Estructura de la Materia, CSIC, Madrid, E-28006, Spain), Simpson, G.S.(LPSC, Université Joseph Fourier Grenoble 1, CNRS/IN2P3, Institut National Polytechnique de Grenoble, Grenoble cedex, F-38026, France), Söderström, P.-A.(RIKEN Nishina Center, RIKEN, 2-1 Hirosawa, Wako-shi, Saitama, 351-0198, Japan), Sumikama, T.(Department of Physics, Tohoku University, Aoba, Sendai, Miyagi, 980-8578, Japan), Baba, H.(RIKEN Nishina Center, RIKEN, 2-1 Hirosawa, Wako-shi, Saitama, 351-0198, Japan), Browne, F.(School of Computing, Engineering and Mathematics, University of Brighton, Brighton, BN2 4JG, United Kingdom), Fukuda, N.(RIKEN Nishina Center, RIKEN, 2-1 Hirosawa, Wako-shi, Saitama, 351-0198, Japan), Gernhäuser, R.(Physik Department E12, Technische Universität München, Garching, D-85748, Germany), Gey, G.(LPSC, Université Joseph Fourier Grenoble 1, CNRS/IN2P3, Institut National Polytechnique de Grenoble, Grenoble cedex, F-38026, France), Inabe, N.(RIKEN Nishina Center, RIKEN, 2-1 Hirosawa, Wako-shi, Saitama, 351-0198, Japan), Isobe, T.(RIKEN Nishina Center, RIKEN, 2-1 Hirosawa, Wako-shi, Saitama, 351-0198, Japan), Jung, H.S.(Department of Physics, Chung-Ang University, Seoul, 156-756, Republic of Korea), Kameda, D.(RIKEN Nishina Center, RIKEN, 2-1 Hirosawa, Wako-shi, Saitama, 351-0198, Japan), Kim, G.D.(Rare Isotope Science Project, Institute for Basic Science, Daejeon, 305-811, Republic of Korea), Kim, Y.-K.(Rare Isotope Science Project, Institute for Basic Science, Daejeon, 305-811, Republic of Korea), Kojouharov, I.(GSI Helmholtzzentrum für Schwerionenforschung GmbH, Darmstadt, 64291, Germany), Kubo, T.(RIKEN Nishina Center, RIKEN, 2-1 Hirosawa, Wako-shi, Saitama, 351-0198, Japan), Kurz, N.(GSI Helmholtzzentrum für Schwerionenforschung GmbH, Darmstadt, 64291, Germany), Kwon, Y.K.(Rare Isotope Science Project, Institute for Basic Science, Daejeon, 305-811, Republic of Korea), Li, Z.(School of Physics, State Key Laboratory of Nuclear Physics and Technology, Peking University, Beijing, 100871, China), Sakurai, H.(RIKEN Nishina Center, RIKEN, 2-1 Hirosawa, Wako-shi, Saitama, 351-0198, Japan), Schaffner, H.(GSI Helmholtzzentrum für Schwerionenforschung GmbH, Darmstadt, 64291, Germany), Steiger, K.(Physik Department E12, Technische Universität München, Garching, D-85748, Germany), Suzuki, H.(RIKEN Nishina Center, RIKEN, 2-1 Hirosawa, Wako-shi, Saitama, 351-0198, Japan), Takeda, H.(RIKEN Nishina Center, RIKEN, 2-1 Hirosawa, Wako-shi, Saitama, 351-0198, Japan), Vajta, Zs.(MTA Atomki, P.O. Box 51, Debrecen, H-4001, Hungary), Watanabe, H.(RIKEN Nishina Center, RIKEN, 2-1 Hirosawa, Wako-shi, Saitama, 351-0198, Japan), Wu, J.(School of Physics, State Key Laboratory of Nuclear Physics and Technology, Peking University, Beijing, 100871, China), Yagi, A.(Department of Physics, Osaka University, Machikaneyama-machi 1-1, Toyonaka, Osaka, 560-0043, Japan), Yoshinaga, K.(Department of Physics, Faculty of Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, Japan), Benzoni, G.(INFN, Sezione di Milano, via Celoria 16, Milano, I-20133, Italy), Bönig, S.(Institut für Kernphysik, Technische Universität Darmstadt, Darmstadt, D-64289, Germany), Chae, K.Y.(Department of Physics, Sungkyunkwan University, Suwon, 440-746, Republic of Korea), Coraggio, L.(Istituto Nazionale di Fisica Nucleare, Complesso Universitario di Monte S. Angelo, Napoli, I-80126, Italy), Covello, A.(Dipartimento di Fisica, Università di Napoli Federico II, Complesso Universitario di Monte S. Angelo, Napoli, I-80126, Italy), Daugas, J.-M.(CEA, DAM, DIF, Arpajon cedex, 91297, France), Drouet, F.(LPSC, Université Joseph Fourier Grenoble 1, CNRS/IN2P3, Institut National Polytechnique de Grenoble, Grenoble cedex, F-38026, France), Gadea, A.(Instituto de Física Corpuscular, CSIC, Univ. of Valencia, Paterna, E-46980, Spain), Gargano, A.(Istituto Nazionale di Fisica Nucleare, Complesso Universitario di Monte S. Angelo, Napoli, I-80126, Italy), Ilieva, S.(Institut für Kernphysik, Technische Universität Darmstadt, Darmstadt, D-64289, Germany), Kondev, F.G.(Nuclear Engineering Division, Argonne National Laboratory, Argonne, IL, 60439, USA), Kröll, T.(Institut für Kernphysik, Technische Universität Darmstadt, Darmstadt, D-64289, Germany), Lane, G.J.(Department of Nuclear Physics, Research School of Physical Sciences and Engineering, Australian National University, Canberra, ACT 0200, Australia), Montaner-Pizá, A.(Instituto de Física Corpuscular, CSIC, Univ. of Valencia, Paterna, E-46980, Spain), Moschner, K.(IKP, University of Cologne, Cologne, D-50937, Germany), Mücher, D.(Institut für Kernphysik, Technische Universität Darmstadt, Darmstadt, D-64289, Germany), Naqvi, F.(Wright Nuclear Structure Laboratory, Yale University, New Haven, CT, 06520-8120, USA), Niikura, M.(Department of Physics, University of Tokyo, Japan, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-0033), Nishibata, H.(Department of Physics, Osaka University, Machikaneyama-machi 1-1, Toyonaka, Osaka, 560-0043, Japan), Odahara, A.(Department of Physics, Osaka University, Machikaneyama-machi 1-1, Toyonaka, Osaka, 560-0043, Japan), Orlandi, R.(Instituut voor Kern- en Stralingsfysica, K.U. Leuven, Heverlee, B-3001, Belgium), Patel, Z.(Department of Physics, University of Surrey, Guildford, GU2 7XH, United Kingdom), Podolyák, Zs.(Department of Physics, University of Surrey, Guildford, GU2 7XH, United Kingdom), and Wendt, A.(IKP, University of Cologne, Cologne, D-50937, Germany)

Subjects
Isomeric decays, Shell model calculations, Nuclear Theory, Physics::Atomic and Molecular Clusters, Transition strengths, Nuclear Experiment, lcsh:Physics, lcsh:QC1-999
Abstract

The decay of an isomeric state in the neutron-rich nucleus 129Cd has been observed via the detection of internal conversion and Compton electrons providing first experimental information on excited states in this nucleus. The isomer was populated in the projectile fission of a 238U beam at the Radioactive Isotope Beam Factory at RIKEN. From the measured yields of γ-rays and internal conversion electrons, a multipolarity of E3 was tentatively assigned to the isomeric transition. A half-life of T1/2=3.6(2) ms was determined for the new state which was assigned a spin of (21/2+), based on a comparison to shell model calculations performed using state-of-the-art realistic effective interactions. Keywords: Isomeric decays, Transition strengths, Shell model calculations

Published
2014

17. Education, Sport and Leisure : Connections and Controversies

Author

McFee, Graham, Tomlinson, Alan, Chelsea School (University of Brighton), McFee, Graham, Tomlinson, Alan, and Chelsea School (University of Brighton)

Subjects
Physical education and training--Curricula--Great Britain
Abstract

Published
2009

18. Documents : a new project

Author

Lewandowska, Marysia, Cummings, Neil, Design Council. Archive, University of Brighton. Gallery, PhotoWorks, Lewandowska, Marysia, Cummings, Neil, Design Council. Archive, University of Brighton. Gallery, and PhotoWorks

Abstract

Joan Flasch Artists' Book Collection

Published
2000

19. Modelling of the Evolution of a Droplet Cloud in a Turbulent Flow

Author

Andreas Papoutsakis, Oyuna Rybdylova, Timur Zaripov, Luminita Danalia, Sergei Sazhin, University of Brighton, School of Computing, Engineering and Mathematics (Brighton), Sir Harry Ricardo Laboratories, Advanced Engineering Centre, School of Computing, Engineering and Mathematics, University of Brighton, Complexe de recherche interprofessionnel en aérothermochimie (CORIA), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), and Lequesne, Sally

Subjects
Physics::Fluid Dynamics, [PHYS]Physics [physics], [PHYS] Physics [physics]
Abstract

International audience; In this work we examine the effect of turbulent mixing on the droplet number density for a cloud of droplets dispersingin a turbulent flow field. The Lagrangian droplets are assumed to be transported and dispersed by the large scalestructures of a resolved field. However, turbulent fluctuations not visible to the filtered solution induce unresolveddispersion of droplets within a droplet cloud. The Fully Lagrangian Approach (FLA) is used to model resolveddroplet dispersion. A model is presented for the prediction of the unresolved turbulent mixing of the droplet numberdensity for a droplet cloud. This model takes into account the turbulent flux for the droplets permeating the surfaceof the cloud via turbulent diffusion. Turbulent diffusion is assumed to be driven by the kinetic energy of the dropletfluctuations induced by the turbulent kinetic energy of the carrier phase. This assumption is supported by DirectNumerical Simulations (DNS) of homogeneous and isotropic turbulence. Additionally, DNS of transition of a planarjet to turbulence is used for the assessment of the mixing model which we use. The calculation of the spatialderivatives for the droplet number densities is performed by projecting the FLA solution on the Eulerian mesh,resulting in a hybrid Lagrangian-Eulerian approach to the problem.

Published
2016

20. Small angle neutron scattering study of globular proteins confined in porous carbons

Author

Krisztina László, Erik Geissler, Sergey V. Mikhalovsky, Irina N. Savina, Balázs Vince Nagy, Isabelle Grillo, Lyuba Mikhalovska, Ajna Tóth, Department of Physical Chemistry and Materials Science, Budapest University of Technology and Economics [Budapest] (BME), School of Pharmacy & Biomolecular Sciences, University of Brighton, Brighton BN2 4GJ, U.K, Institut Laue-Langevin (ILL), ILL, LIPHY BIOP, Laboratoire Interdisciplinaire de Physique [Saint Martin d’Hères] (LIPhy), Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF), CNRS general laboratory funding, OTKA (Hungary), University of Brighton (UK), Institut Laue-Langevin, LIPhy, Budapest University of Technology and Economics, University of Brighton, and Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS)

Subjects
chemistry.chemical_classification, 28.20.Cz,87.14.E-,61.43.Gt,68.43.-h,81.05.U, Materials science, Aqueous solution, Chemistry(all), Globular protein, Small-angle X-ray scattering, chemistry.chemical_element, Aerogel, 02 engineering and technology, General Chemistry, Polymer, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, Small-angle neutron scattering, 0104 chemical sciences, Crystallography, Adsorption, chemistry, General Materials Science, [PHYS.PHYS.PHYS-CHEM-PH]Physics [physics]/Physics [physics]/Chemical Physics [physics.chem-ph], 0210 nano-technology, Carbon
Abstract

International audience; This article reports measurements of the concentration distribution of two model proteins adsorbed from aqueous solution by two different high surface area carbons, using small angle neutron and X-ray scattering (SANS and SAXS). The proteins investigated were bovine serum albumin (67 kDa), and bovine pancreatic trypsin inhibitor (BPTI), also known under the name aprotinin (6.5 kDa). The two carbon substrates were C1, an open structured carbon aerogel derived from a resorcinol– formaldehyde polymer aerogel, and C2, a commercial nanoporous carbon from MAST Carbon (UK). Although both C1 and C2 possess a high proportion of pores that are either closed or inaccessible to low temperature nitrogen vapour, the size distribution of the accessible pores is broad enough to accommodate BSA molecules. In C1, which is hydrophobic, the BSA molecules migrate individually into pores that are compatible with their size, whereas BPTI forms clusters having the same size as BSA. With C2, the hydrophilic internal surface limits the adsorption efficiency. The strong adhesion of proteins to hydrophilic surfaces prevents diffusion of either molecule into the micro-and nanopores. In this sample both BSA and BPTI form large clusters. These observations have relevance in biomedical applications, such as haemoperfusion or as a medium for protein storage.

Published
2016

21. Is airway damage during physical exercise related to airway dehydration? Inputs from a computational model

Author

Cyril Karamaoun, Benoît Haut, Grégory Blain, Alfred Bernard, Frédéric Daussin, Jeanne Dekerle, Valérie Bougault, Benjamin Mauroy, Université de Lille, Univ. Artois, Univ. Littoral Côte d’Opale, Laboratoire Jean Alexandre Dieudonné [LJAD], Advanced Technologies in Information Processing Systems [ATIPS Labs], LAMHESS - E1 Performance Sportive : Optimisation de la performance de haut niveau, Université Catholique de Louvain = Catholic University of Louvain [UCL], Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369 - ULR 4488 [URePSSS], University of Brighton, Laboratoire Motricité Humaine Expertise Sport Santé [LAMHESS], Laboratoire Motricité Humaine Expertise Sport Santé (LAMHESS), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Université de Toulon (UTLN)-Université Côte d'Azur (UCA), and COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université de Toulon (UTLN)-Université Côte d'Azur (UCA)

Subjects
[SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, Adult, airway dehydration threshold, computational modeling, exercise ventilation, healthy participants, serum cc16, Dehydration, Physiology, Bronchoconstriction, Water, cc16, minute ventilation, exercise-induced airway damage, computational model, Physiology (medical), [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Exercise Test, Humans, [MATH]Mathematics [math], Exercise, airway dehydration
Abstract

In healthy subjects, at low minute ventilation (V_ E) during physical exercise, the water content and temperature of the airways are well regulated. However, with the increase in V_ E, the bronchial mucosa becomes dehydrated and epithelial damage occurs. Our goal was to demonstrate the correspondence between the ventilatory threshold inducing epithelial damage, measured experimentally, and the dehydration threshold, estimated numerically. In 16 healthy adults, we assessed epithelial damage before and following a 30-min continuous cycling exercise at 70% of maximal work rate, by measuring the variation pre- to postexercise of serum club cell protein (cc16/cr). Blood samples were collected at rest, just at the end of the standardized 10 min warm-up, and immediately, 30 min and 60 min postexercise. Mean V_ E during exercise was kept for analysis. Airway water and heat losses were estimated using a computational model adapted to the experimental conditions and were compared with a literature-based threshold of bronchial dehydration. Eleven participants exceeded the threshold for bronchial dehydration during exercise (group A) and five did not (group B). Compared with post warm-up, the increase in cc16/cr postexercise was significant (mean increase ± SE: 0.48 ± 0.08 ng·L 1 only in group A but not in group B (mean difference ± SE: 0.10 ± 0.04 ng·L 1). This corresponds to an increase of 101 ± 32% [range: 16%–367%] in group A (mean ± SE). Our findings suggest that the use of a computational model may be helpful to estimate an individual dehydration threshold of the airways that is associated with epithelial damage during physical exercise. 132;4

Published
2022

22. Implementation and effectiveness of a linkage to HIV care intervention in rural South Africa (ANRS 12249 TasP trial)

Author

Plazy, Mélanie, Diallo, Adama, Hlabisa, Thabile, Okesola, Nonhlanhla, Iwuji, Collins, Herbst, Kobus, Boyer, Sylvie, Lert, France, Mcgrath, Nuala, Pillay, Deenan, Dabis, François, Larmarange, Joseph, Orne-Gliemann, Joanna, Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Global Health in the Global South (GHiGS), Institut de Recherche pour le Développement (IRD)- Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Africa Health Research Institute [Durban/Mtubatuba] (AHRI), University of Sussex, University of Brighton, Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, University of Southampton, University College of London [London] (UCL), Centre population et développement (CEPED - UMR_D 196), Institut de Recherche pour le Développement (IRD)-Université Paris Cité (UPCité), Santé, vulnérabilités et relations de genre au sud (SAGESUD - ERL Inserm U1244), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre population et développement (CEPED - UMR_D 196), Institut de Recherche pour le Développement (IRD)-Université Paris Cité (UPCité)-Institut de Recherche pour le Développement (IRD)-Université Paris Cité (UPCité), and ANRS, BMGF

Subjects
Multidisciplinary, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Abstract

Background Timely linkage to care and ART initiation is critical to decrease the risks of HIV-related morbidity, mortality and HIV transmission, but is often challenging. We report on the implementation and effectiveness of a linkage-to-care intervention in rural KwaZulu-Natal, South Africa. Methods In the ANRS 12249 TasP trial on Universal Testing and Treatment (UTT) implemented between 2012–2016, resident individuals ≥16 years were offered home-based HIV testing every six months. Those ascertained to be HIV-positive were referred to trial clinics. Starting May 2013, a linkage-to-care intervention was implemented in both trial arms, consisting of tracking through phone calls and/or home visits to “re-refer” people who had not linked to care to trial clinics within three months of the first home-based referral. Fidelity in implementing the planned intervention was described using Kaplan-Meier estimation to compute conditional probabilities of being tracked and of being re-referred by the linkage-to-care team. Effect of the intervention on time to linkage-to-care was analysed using a Cox regression model censored for death, migration, and end of data follow-up. Results Among the 2,837 individuals (73.7% female) included in the analysis, 904 (32%) were tracked at least once, and 573 of them (63.4%) were re-referred. Probabilities of being re-referred was 17% within six months of first referral and 31% within twelve months. Compared to individuals not re-referred by the intervention, linkage-to-care was significantly higher among those with at least one re-referral through phone call (adjusted hazard ratio [aHR] = 1.82; 95% confidence interval [95% CI] = 1.47–2.25), and among those with re-referral through both phone call and home visit (aHR = 3.94; 95% CI = 2.07–7.48). Conclusions Phone calls and home visits following HIV testing were challenging to implement, but appeared effective in improving linkage-to-care amongst those receiving the intervention. Such patient-centred strategies should be part of UTT programs to achieve the UNAIDS 95-95-95 targets.

Published
2023

23. The Relationship between Fatigue and Actigraphy-Derived Sleep and Rest–Activity Patterns in Cancer Survivors

Author

Guillaume Y. Millet, Tristan Martin, S. Nicole Culos-Reed, Rosie Twomey, Mary E. Medysky, John Temesi, Mobilités : Vieillissement, Pathologie, Santé (COMETE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU), University of Calgary, Motricité, interactions, performance EA 4334 / Movement - Interactions - Performance (MIP), Le Mans Université (UM)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université de Nantes - UFR des Sciences et Techniques des Activités Physiques et Sportives (UFR STAPS), Université de Nantes (UN)-Université de Nantes (UN), University of Brighton, Oregon Health and Science University [Portland] (OHSU), University of Northumbria at Newcastle [United Kingdom], Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM), Martin, Tristan, Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Université de Nantes - UFR des Sciences et Techniques des Activités Physiques et Sportives (UFR STAPS), and Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Le Mans Université (UM)

Subjects
insomnia, [SDV]Life Sciences [q-bio], 0302 clinical medicine, Cancer Survivors, Neoplasms, Insomnia, Medicine, Cancer-related fatigue, Fatigue, RC254-282, ComputingMilieux_MISCELLANEOUS, 0303 health sciences, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Sleep in non-human animals, humanities, SportRxiv|Rehabilitation and Therapy|Medicine and Health, 3. Good health, [SDV] Life Sciences [q-bio], bepress|Social and Behavioral Sciences|Sociology, SportRxiv|Sport and Exercise Science, 030220 oncology & carcinogenesis, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], medicine.symptom, Sleep onset, [SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT], medicine.medical_specialty, Rest, bepress|Life Sciences|Kinesiology, bepress|Medicine and Health Sciences|Rehabilitation and Therapy, B100, [SDV.CAN]Life Sciences [q-bio]/Cancer, Article, 03 medical and health sciences, SportRxiv|Rehabilitation and Therapy, [SDV.CAN] Life Sciences [q-bio]/Cancer, Humans, bepress|Medicine and Health Sciences|Rehabilitation and Therapy|Other Rehabilitation and Therapy, SportRxiv|Rehabilitation and Therapy|Other Rehabilitation and Therapy, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], SportRxiv|Sport and Exercise Science|Physical Activity, 030304 developmental biology, [SDV.OT] Life Sciences [q-bio]/Other [q-bio.OT], business.industry, Cancer, Actigraphy, cancer-related fatigue, Rest activity, medicine.disease, C600, B900, Physical therapy, rest–activity cycle, Sleep onset latency, Sleep, business, 030217 neurology & neurosurgery, actigraphy
Abstract

Cancer-related fatigue can continue long after curative cancer treatment. The aim of this study was to investigate sleep and rest–activity cycles in fatigued and non-fatigued cancer survivors. We hypothesized that sleep and rest–activity cycles would be more disturbed in people experiencing clinically-relevant fatigue, and that objective measures of sleep would be associated with the severity of fatigue in cancer survivors. Cancer survivors (n = 87) completed a 14-day wrist actigraphy measurement to estimate their sleep and rest–activity cycles. Fatigue was measured using the Functional Assessment of Chronic Illness Therapy Fatigue Scale (FACIT-F). Participants were dichotomised into two groups using a previously validated score (fatigued n = 51 and non-fatigued n = 36). The participant’s perception of sleep was measured using the Insomnia Severity Index (ISI). FACIT-F score was correlated with wake after sleep onset (r = −0.28, p = 0.010), sleep efficiency (r = 0.26, p = 0.016), sleep onset latency (r = −0.31, p = 0.044) and Insomnia Severity Index (ISI) score (r = −0.56, p &lt, 0.001). The relative amplitude of the rest–activity cycles was lower in the fatigued vs. the non-fatigued group (p = 0.017, d = 0.58). After treatment for cancer, the severity of cancer-related fatigue is correlated with specific objective measures of sleep, and there is evidence of rest–activity cycle disruption in people experiencing clinically-relevant fatigue.

Published
2021

24. Phase separation in the polyurethane/poly(2-hydroxyethylmethacrylate) semi-interpenetrating polymer networks synthesized by different ways

Author

Karabanova, Lyudmyla, Boiteux, Gisèle, Seytre, Gérard, Stevenson, Isabelle, Lloyd, Andrew W., Mikhalovsky, Sergey V., Helias, Mikle, Sergeeva, Lyudmyla M., Lutsyk, Elena D., Svyatyna, Anna V., Institute of Macromolecular Chemistry of National Academy of Sciences of Ukraine, Ingénierie des Matériaux Polymères - Laboratoire des Matériaux Polymères et des Biomatériaux (IMP-LMPB), Centre National de la Recherche Scientifique (CNRS)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut de Chimie du CNRS (INC), Department of Pharmacy, University of Brighton, and University of Brighton

Subjects
[CHIM.POLY]Chemical Sciences/Polymers
Abstract

International audience; The thermal, dynamic mechanical analysis, morphology and mechanical properties of semi-interpenetrating polymer networks based on crosslinked polyurethane (PU) and poly(2-hydroxyethyl methacrylate) (PHEMA) synthesized by photopolymerization and by thermopolymerization have been investigated. The thermal analysis has evidenced the two glass temperature transitions in the semi-ΙPNs and this is confirmed by the thermodynamic miscibility investigation of the systems. The Dynamic Mechanical Analysis spectra have shown that the phase separation is more significant in the thermopolymerized semi-ΙPNs: the tan δ peaks of constituent polymers are more distinct and the minimum between the two peaks is deeper. The calculated segregation degree values of semi-IPN's components are significantly higher for thermopolymerized semi-IPNs, thereby the process of phase separation in the thermopolymerized semi-IPNs is more developed. The structures of two series of samples investigated by SEM are completely different. The mechanical properties reflect these changes in structure of semi-IPNs with increasing amount of PHEMA and with the changing of the method of synthesis. The results suggest that the studied semi-IPNs are two-phase systems with incomplete phase separation. The semi-IPN samples with early stage of phase separation demonstrate higher mechanical characteristics.

Published
2008

25. Gradient composites and semi-interpenetrating polymer. Networks based on polyurethane and poly(2-hydroxyethyl Methacrylate) for biomedical applications

Author

Karabanova, Lyudmyla, Sergeeva, Lyudmyla M., Lutsyk, Elena D., Svyatyna, Anna V., Seytre, Gérard, Lachenal, Gilbert, Boiteux, Gisèle, Lloyd, Andrew W., Mikhalovsky, Sergey V., Institute of Macromolecular Chemistry of National Academy of Sciences of Ukraine, Ingénierie des Matériaux Polymères - Laboratoire des Matériaux Polymères et des Biomatériaux (IMP-LMPB), Centre National de la Recherche Scientifique (CNRS)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut de Chimie du CNRS (INC), Department of Pharmacy, University of Brighton, and University of Brighton

Subjects
[CHIM.POLY]Chemical Sciences/Polymers
Published
2007

26. Gradient polyurethane/PHEMA composites and semi-interpenetrating polymer networks for biomedical application

Author

Karabanova, Lyudmyla, Sergeeva, Lyudmyla M., Brovko, O.L., Lloyd, Andrew W., Mikhalovsky, Sergey V., Boiteux, Gisèle, Seytre, Gérard, Institute of Macromolecular Chemistry of National Academy of Sciences of Ukraine, Department of Pharmacy, University of Brighton, University of Brighton, Ingénierie des Matériaux Polymères - Laboratoire des Matériaux Polymères et des Biomatériaux (IMP-LMPB), Centre National de la Recherche Scientifique (CNRS)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Institut de Chimie du CNRS (INC)

Subjects
[CHIM.POLY]Chemical Sciences/Polymers
Published
2007

27. Investigating the basal shear zone of the submarine Tuaheni Landslide Complex, New Zealand: a core‐log‐seismic integration study

Author

G. J. Crutchley, J. Elger, J. Kuhlmann, J. J. Mountjoy, A. Orpin, A. Georgiopoulou, J. Carey, B. Dugan, S. Cardona, S. Han, A. Cook, E. J. Screaton, I. A. Pecher, P. Barnes, K. Huhn, Elger, J., 1 GEOMAR Helmholtz Centre for Ocean Research Kiel Kiel Germany, Kuhlmann, J., 2 Centre for Marine Environmental Sciences (MARUM) University of Bremen Bremen Germany, Mountjoy, J. J., 3 National Institute of Water and Atmospheric Research (NIWA) Wellington New Zealand, Orpin, A., Georgiopoulou, A., 4 School of Environment and Technology University of Brighton Brighton UK, Carey, J., 5 GNS Science Lower Hutt New Zealand, Dugan, B., 6 Colorado School of Mines Golden CO USA, Cardona, S., Han, S., 7 Jackson School of Geosciences The University of Texas at Austin Austin TX USA, Cook, A., 8 Ohio State University Columbus OH USA, Screaton, E. J., 9 University of Florida Gainesville FL USA, Pecher, I. A., 10 School of Environment University of Auckland Auckland New Zealand, Barnes, P., and Huhn, K.

Subjects
Geophysics, 010504 meteorology & atmospheric sciences, Space and Planetary Science, Geochemistry and Petrology, ddc:551, Earth and Planetary Sciences (miscellaneous), 14. Life underwater, 010502 geochemistry & geophysics, 01 natural sciences, ddc:622.15, 0105 earth and related environmental sciences
Abstract

Although submarine landslides have been studied for decades, a persistent challenge is the integration of diverse geoscientific datasets to characterize failure processes. We present a core‐log‐seismic integration study of the Tuaheni Landslide Complex to investigate intact sediments beneath the undeformed seafloor as well as post‐failure landslide deposits. Beneath the undeformed seafloor are coherent reflections underlain by a weakly‐reflective and chaotic seismic unit. This chaotic unit is characterized by variable shear strength that correlates with density fluctuations. The basal shear zone of the Tuaheni landslide likely exploited one (or more) of the low shear strength intervals. Within the landslide deposits is a widespread “Intra‐debris Reflector”, previously interpreted as the landslide's basal shear zone. This reflector is a subtle impedance drop around the boundary between upper and lower landslide units. However, there is no pronounced shear strength change across this horizon. Rather, there is a pronounced reduction in shear strength ∼10–15 m above the Intra‐debris Reflector that presumably represents an induced weak layer that developed during failure. Free gas accumulates beneath some regions of the landslide and is widespread deeper in the sedimentary sequence, suggesting that free gas may have played a role in pre‐conditioning the slope to failure. Additional pre‐conditioning or failure triggers could have been seismic shaking and associated transient fluid pressure. Our study underscores the importance of detailed core‐log‐seismic integration approaches for investigating basal shear zone development in submarine landslides., Plain Language Summary: Submarine landslides move enormous amounts of sediment across the seafloor and have the potential to generate damaging tsunamis. To understand how submarine landslides develop, we need to be able to image and sample beneath the seafloor in regions where landslides have occurred. To image beneath the seafloor we generate sound waves in the ocean and record reflections from those waves, enabling us to produce “seismic images” of sediment layers and structures beneath the seafloor. We then use scientific drilling to sample the sediment layers and measure physical properties. In this study, we combine seismic images and drilling results to investigate a submarine landslide east of New Zealand's North Island. Drilling next to the landslide revealed a ∼25 m‐thick layer of sediment (from ∼75–95 m below the seafloor) that has strong variations in sediment strength and density. We infer that intervals of relatively low strength within this layer developed into the main sliding surface of the landslide. Additionally, results from within the landslide suggest that the process of landslide emplacement has induced a zone of weak sediments closer to the seafloor. Our study demonstrates how combining seismic images and drilling data helps to understand submarine landslide processes., Key Points: We integrate scientific drilling data with seismic reflection data to investigate the submarine Tuaheni Landslide Complex. Basal shear zone of the landslide likely exploited a relatively low shear strength interval within an older (buried) mass transport deposit. Landslide emplacement seems to have induced an additional weak zone that is shallower than the interpreted base of the landslide deposit., Marsden Fund (Royal Society of New Zealand Marsden Fund) http://dx.doi.org/10.13039/501100009193, European Consortium for Ocean Research Drilling, International Ocean Drilling Program, Science Support Program, New Zealand Ministry for Business Innovation and Employment, Deutsche Forschungsgemeinschaft (DFG) http://dx.doi.org/10.13039/501100001659, https://doi.pangaea.de/10.1594/PANGAEA.928073

Published
2022

28. Epochs, events and episodes: Marking the geological impact of humans

Author

Colin N. Waters, Mark Williams, Jan Zalasiewicz, Simon D. Turner, Anthony D. Barnosky, Martin J. Head, Scott L. Wing, Michael Wagreich, Will Steffen, Colin P. Summerhayes, Andrew B. Cundy, Jens Zinke, Barbara Fiałkiewicz-Kozieł, Reinhold Leinfelder, Peter K. Haff, J.R. McNeill, Neil L. Rose, Irka Hajdas, Francine M.G. McCarthy, Alejandro Cearreta, Agnieszka Gałuszka, Jaia Syvitski, Yongming Han, Zhisheng An, Ian J. Fairchild, Juliana A. Ivar do Sul, Catherine Jeandel, University of Leicester, Stanford University, Brock University [Canada], University of Vienna [Vienna], Australian National University (ANU), University of Cambridge [UK] (CAM), University of Brighton, Australian Institute of Marine Science (AIMS), Department of Biogeography and Paleoecology, Adam Mickiewicz University in Poznań (UAM), Freie Universität Berlin, Duke University [Durham], Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Universidad del Pais Vasco / Euskal Herriko Unibertsitatea [Espagne] (UPV/EHU), Jan Kochanowski University, Institute of Arctic Alpine Research [University of Colorado Boulder] (INSTAAR), University of Colorado [Boulder], Laboratoire d'études en Géophysique et océanographie spatiales (LEGOS), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), and Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS)

Subjects
Great Acceleration Event Array, [SDE.MCG]Environmental Sciences/Global Changes, Anthropocene, chronostratigraphy, 500 Naturwissenschaften und Mathematik::550 Geowissenschaften, Geologie::550 Geowissenschaften, General Earth and Planetary Sciences, Anthropogenic modification episode
Abstract

Event stratigraphy is used to help characterise the Anthropocene as a chronostratigraphic concept, based on analogous deep-time events, for which we provide a novel categorization. Events in stratigraphy are distinct from extensive, time-transgressive ‘episodes’ – such as the global, highly diachronous record of anthropogenic change, termed here an Anthropogenic Modification Episode (AME). Nested within the AME are many geologically correlatable events, the most notable being those of the Great Acceleration Event Array (GAEA). This isochronous array of anthropogenic signals represents brief, unique events evident in geological deposits, e.g.: onset of the radionuclide ‘bomb-spike’; appearance of novel organic chemicals and fuel ash particles; marked changes in patterns of sedimentary deposition, heavy metal contents and carbon/nitrogen isotopic ratios; and ecosystem changes leaving a global fossil record; all around the mid-20th century. The GAEA reflects a fundamental transition of the Earth System to a new state in which many parameters now lie beyond the range of Holocene variability. Globally near-instantaneous events can provide robust primary guides for chronostratigraphic boundaries. Given the intensity, magnitude, planetary significance and global isochroneity of the GAEA, it provides a suitable level for recognition of the base of the Anthropocene as a series/epoch. Contributing authors are members of the Anthropocene Working Group (AWG), of the Subcommission on Quaternary Stratigraphy (SQS), a component body of the International Commission on Stratigraphy (ICS). The paper was inspired by a publication by Gibbard et al. (2021), which initiated our critical enquiry into the Anthropocene as a geological event. The authors thank the anonymous referees and editor, Alessandra Negri, whose comments helped improve this manuscript. We are also grateful to Lucy E. Edwards for alerting us at the proof stage to the NASC requirements for defining episodes formally

Published
2022
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29. Near the Brink: An Example of a Weak Layer in the Tuaheni Landslide Complex, Hikurangi Margin, New Zealand

Author

Cardona, Sebastian, Reece, Julia, Dugan, Brandon, Wood, Lesli, Nole, Michael, Georgiopoulou, Aggeliki, Mountjoy, Joshu J., Underwood, Michael B., Brunet, Morgane, Al., Et, Texas A&M University [College Station], Colorado School of Mines, Sandia National Labs, University of Brighton, National Institute of Water and Atmospheric Research [Wellington] (NIWA), University of Missouri [Columbia] (Mizzou), University of Missouri System, Géosciences Rennes (GR), Université de Rennes (UR)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR), Université de Rennes (UR)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS), and Dubigeon, Isabelle

Subjects
[SDU.STU] Sciences of the Universe [physics]/Earth Sciences, [SDU.STU]Sciences of the Universe [physics]/Earth Sciences
Abstract

International audience; Weak layers in submarine margins are often cited to explain landslide occurrence or reactivation, but little is known about the origin of these weak layers, and it is not always clear if the weak layer existed prior to the landslide or resulted from the failure process. IODP Expedition 372 logged, cored, and sampled Site U1517 to gain deeper insight into the interaction of gas hydrate and submarine landslides. Using physical data and core from Site U1517, we identify and characterize a weak layer in Tuaheni Landslide Complex (TLC) in the Hikurangi margin, New Zealand. The TLC is believed to behave in a creeping mode. We hypothesize that this weak layer could have been the result of deformation during failure (e.g., strength weakening) or the result of inherent weakness in the sediments. The identified weak layer in the TLC has an anomalous reduction in shear strength, porosity, and permeability that cannot be attributed to normal consolidation or composition changes. Furthermore, this weak layer could act as a potential slip plane for future creeping (i.e., reactivation) in the presence of a minor change in the stress or pressure field (e.g., earthquake). Based on scanning electron microscopic imaging of core samples, we conclude that the properties in the weak layer could be the result of mechanical rearrangement of clay particles that form “clay bridges” around framework grains. The measured low strength of the weak layer is approximately equal to the downslope gravitational stresses suggesting that the landslide is at or near failure— which may explain the creep-like behavior attributed to this landslide. Based on the physical properties from the TLC, we estimate the factor of safety and run numerical simulations using Plaxis software. We finally create sensitivity analysis to test likely scenarios that could reactivate this landslide. This study and methodology are relevant for many other underwater margins around the world where submarine landslides may be at or near the brink of failing.

Published
2021

30. Low-Valent Calix[4]arene Glycoconjugates Based on Hydroxamic Acid Bearing Linkers as Potent Inhibitors in a Model of Ebola Virus Cis-Infection and HCMV-gB-Recombinant Glycoprotein Interaction with MDDC Cells by Blocking DC-SIGN

Author

Catherine Mullié, Peter J. Cragg, Franck Fieschi, Vanessa Porkolab, Roman Sommer, Coraline Cheneau, Mohamed Amine Ben Maaouia, Franck Halary, David Mathiron, Rafael Delgado, Mohammed Benazza, Rym Abidi, Serge Pilard, Joanna Luczkowiak, Marwa Taouai, Khouloud Chakroun, Laboratoire de Glycochimie, des Antimicrobiens et des Agro-ressources - UMR CNRS 7378 (LG2A ), Université de Picardie Jules Verne (UPJV)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut de biologie structurale (IBS - UMR 5075), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA), Instituto de Investigación Hospital Universitario 12 de Octubre, Centre de Recherche en Transplantation et Immunologie (U1064 Inserm - CRTI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Plateforme Analytique (PFA), Université de Picardie Jules Verne (UPJV), Laboratoire d'Application de la Chimie aux Ressources et Substances Naturelles de l'Environnement, Faculté des Sciences de Bizerte [Université de Carthage], Université de Carthage - University of Carthage-Université de Carthage - University of Carthage, Agents infectieux, résistance et chimiothérapie - UR UPJV 4294 (AGIR ), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, School of Pharmacy & Biomolecular Sciences, University of Brighton, Brighton BN2 4GJ, U.K, Institut de transplantation urologie-néphrologie (ITUN), and Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)

Subjects
viruses, Cytomegalovirus, Receptors, Cell Surface, Plasma protein binding, medicine.disease_cause, Hydroxamic Acids, Jurkat cells, Antiviral Agents, Models, Biological, Cell Line, chemistry.chemical_compound, Jurkat Cells, Viral Proteins, Phenols, Drug Discovery, medicine, Humans, [CHIM]Chemical Sciences, Avidity, Lectins, C-Type, ComputingMilieux_MISCELLANEOUS, Glycoproteins, chemistry.chemical_classification, Ebola virus, biology, Cell adhesion molecule, virus diseases, Heparan sulfate, Dendritic Cells, Ebolavirus, Virology, Recombinant Proteins, DC-SIGN, chemistry, biology.protein, Molecular Medicine, Calixarenes, Glycoprotein, Cell Adhesion Molecules, Glycoconjugates, Protein Binding
Abstract

In addition to a variety of viral-glycoprotein receptors (e.g., heparan sulfate, Niemann-Pick C1, etc.), dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN), from the C-type lectin receptor family, plays one of the most important pathogenic functions for a wide range of viruses (e.g., Ebola, human cytomegalovirus (HCMV), HIV-1, severe acute respiratory syndrome coronavirus 2, etc.) that invade host cells before replication; thus, its inhibition represents a relevant extracellular antiviral therapy. We report two novel p-tBu-calixarene glycoclusters 1 and 2, bearing tetrahydroxamic acid groups, which exhibit micromolar inhibition of soluble DC-SIGN binding and provide nanomolar IC50 inhibition of both DC-SIGN-dependent Jurkat cis-cell infection by viral particle pseudotyped with Ebola virus glycoprotein and the HCMV-gB-recombinant glycoprotein interaction with monocyte-derived dendritic cells expressing DC-SIGN. A unique cooperative involvement of sugar, linker, and calixarene core is likely behind the strong avidity of DC-SIGN for these low-valent systems. We claim herein new promising candidates for the rational development of a large spectrum of antiviral therapeutics.

Published
2021

31. The bony labyrinth of StW 573 ('Little Foot'): Implications for early hominin evolution and paleobiology

Author

Kristian J. Carlson, Dominic Stratford, Jelle Dhaene, Frikkie de Beer, Laurent Bruxelles, Tea Jashashvili, Juliet McClymont, Kudakwashe Jakata, Robin H. Crompton, Ronald J. Clarke, Kathleen Kuman, Amélie Beaudet, Jason L. Heaton, Travis Rayne Pickering, University of Pretoria - Department of Anatomy, University of the Witwatersrand [Johannesburg] (WITS), Institut national de recherches archéologiques préventives (Inrap), Institut Français de Recherche en Afrique - Nigeria (IFRA-Nigeria), Centre National de la Recherche Scientifique (CNRS), University of Liverpool, South African Nuclear Energy Corporation [Pretoria] (NECSA), Universiteit Gent = Ghent University [Belgium] (UGENT), Birmingham-Southern College, Evolutionary Studies Institute, and University of Brighton

Subjects
Sterkfontein, 010506 paleontology, [SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, Australopithecus, Morphology (biology), Context (language use), 01 natural sciences, [SHS]Humanities and Social Sciences, Paranthropus robustus, Bony labyrinth, South Africa, Inner ear, medicine, Animals, Assemblage (archaeology), 0601 history and archaeology, Life History Traits, Australopithecus africanus, Ecology, Evolution, Behavior and Systematics, 0105 earth and related environmental sciences, 060101 anthropology, biology, Fossils, Semicircular canals, Hominidae, 06 humanities and the arts, biology.organism_classification, Biological Evolution, Cochlea, medicine.anatomical_structure, Evolutionary biology, Ear, Inner, Anthropology, Paranthropus
Abstract

International audience; Because of its exceptional degree of preservation and its geological age of ∼3.67 Ma, StW 573 makes an invaluable contribution to our understanding of early hominin evolution and paleobiology. The morphology of the bony labyrinth has the potential to provide information about extinct primate taxonomic diversity, phylogenetic relationships and locomotor behaviour. In this context, we virtually reconstruct and comparatively assess the bony labyrinth morphology in StW 573. As comparative material, we investigate 17 southern African hominin specimens from Sterkfontein, Swartkrans and Makapansgat (plus published data from two specimens from Kromdraai B), attributed to Australopithecus, early Homo or Paranthropus, as well as 10 extant human and 10 extant chimpanzee specimens. We apply a landmark-based geometric morphometric method for quantitatively assessing labyrinthine morphology. Morphology of the inner ear in StW 573 most closely resembles that of another Australopithecus individual from Sterkfontein, StW 578, recovered from the Jacovec Cavern. Within the limits of our sample, we observe a certain degree of morphological variation in the Australopithecus assemblage of Sterkfontein Member 4. Cochlear morphology in StW 573 is similar to that of other Australopithecus as well as to Paranthropus specimens included in this study, but it is substantially different from early Homo. Interestingly, the configuration of semicircular canals in Paranthropus specimens from Swartkrans differs from other fossil hominins, including StW 573. Given the role of the cochlea in the sensory-driven interactions with the surrounding environment, our results offer new perspectives for interpreting early hominin behaviour and ecology. Finally, our study provides additional evidence for discussing the phylogenetic polarity of labyrinthine traits in southern African hominins.

Published
2019

32. Editorial for Special Issue 'Rare Earth Deposits and Challenges of World REE Demand for High-Tech and Green-Tech at the Beginning of the 3rd Millennium'

Author

Stefano Salvi, Martin Smith, Jindřich Kynický, Mendel University in Brno (MENDELU), University of Brighton, Géosciences Environnement Toulouse (GET), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), and Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)

Subjects
lcsh:Mineralogy, lcsh:QE351-399.2, ComputerSystemsOrganization_COMPUTERSYSTEMIMPLEMENTATION, Rare earth, [SDU.STU.PE]Sciences of the Universe [physics]/Earth Sciences/Petrography, [SDU.STU]Sciences of the Universe [physics]/Earth Sciences, Geology, 010501 environmental sciences, 010502 geochemistry & geophysics, Geotechnical Engineering and Engineering Geology, 01 natural sciences, High tech, ComputingMilieux_GENERAL, n/a, Economy, Hardware_GENERAL, [SDU.STU.AG]Sciences of the Universe [physics]/Earth Sciences/Applied geology, ComputingMilieux_MISCELLANEOUS, 0105 earth and related environmental sciences, [SDU.STU.MI]Sciences of the Universe [physics]/Earth Sciences/Mineralogy
Abstract

We are living in a time of unprecedented technological innovation [...]

Published
2021

33. A Systematic Review of Reproducibility Research in Natural Language Processing

Author

Ehud Reiter, Shubham Agarwal, Anya Belz, Anastasia Shimorina, University of Brighton, Heriot-Watt University [Edinburgh] (HWU), Natural Language Processing : representations, inference and semantics (SYNALP), Department of Natural Language Processing & Knowledge Discovery (LORIA - NLPKD), Laboratoire Lorrain de Recherche en Informatique et ses Applications (LORIA), Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire Lorrain de Recherche en Informatique et ses Applications (LORIA), Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), University of Aberdeen, Merlo, Paola, Tiedemann, Jörg, and Tsarfaty, Reut

Subjects
FOS: Computer and information sciences, Reproducibility, Computer Science - Computation and Language, business.industry, Computer science, Computational linguistics, computer.software_genre, Field (computer science), [INFO.INFO-CL]Computer Science [cs]/Computation and Language [cs.CL], Snapshot (photography), Artificial intelligence, business, computer, Computation and Language (cs.CL), Natural language processing
Abstract

Against the background of what has been termed a reproducibility crisis in science, the NLP field is becoming increasingly interested in, and conscientious about, the reproducibility of its results. The past few years have seen an impressive range of new initiatives, events and active research in the area. However, the field is far from reaching a consensus about how reproducibility should be defined, measured and addressed, with diversity of views currently increasing rather than converging. With this focused contribution, we aim to provide a wide-angle, and as near as possible complete, snapshot of current work on reproducibility in NLP, delineating differences and similarities, and providing pointers to common denominators., Comment: To be published in proceedings of EACL'21

Published
2021

34. An Automated Tool to Support an Intelligence Learner Management System Using Learning Analytics and Machine Learning

Author

Hasan Mahmud, Haralambos Mouratidis, Shareeful Islam, University of East London (UEL), University of Brighton, Department of Computer and Systems Science [Stockholm], Stockholm University-Royal Institute of Technology [Stockholm] (KTH ), Mediprospects, Ilias Maglogiannis, John Macintyre, Lazaros Iliadis, TC 12, and WG 12.5

Subjects
Computer science, Learning analytics, Machine learning, computer.software_genre, Perspective analytics, Learning opportunities, Research community, 0502 economics and business, [INFO]Computer Science [cs], Computer Sciences, business.industry, 05 social sciences, Perspective (graphical), 050301 education, Predictive analytics, Datavetenskap (datalogi), Analytics, Management system, Individual learning, 050211 marketing, Artificial intelligence, business, 0503 education, computer
Abstract

Part 13: Machine Learning; International audience; Learner Management Systems (LMSs) are widely deployed across the industry as they provide a cost-saving approach that can support flexible learning opportunities. Despite their benefits, LMSs fail to cater for individual learning behavior and needs and support individualised prediction and progression. Learning Analytics (LAs) support these gaps by correlating existing learner data to provide meaningful predictive and prescriptive analysis. The industry and research community have already recognised the necessity of LAs to support modern learning needs. But a little effort has been directed towards the integration of LA into LMSs. This paper presents a novel automated Intelligence Learner Management System (iLMS) that integrates learner management and learning analytics into a single platform. The presented iLMS considers Machine Learning techniques to support learning analytics including descriptive, predictive and perspective analytics.

Published
2021

35. Cyber Supply Chain Threat Analysis and Prediction Using Machine Learning and Ontology

Author

Haralambos Mouratidis, Umar Ismai, Abel Yeboah-Ofori, Shareeful Islam, Spyridon Papastergiou, University of East London (UEL), University of Brighton, University of Piraeus, Ilias Maglogiannis, John Macintyre, Lazaros Iliadis, TC 12, and WG 12.5

Subjects
Cyber threat intelligence, Computer science, Supply chain, 02 engineering and technology, Cyber-security, Ontology (information science), Machine learning, computer.software_genre, Cyber security, Outcome (game theory), Domain (software engineering), Cyber supply chain, 020204 information systems, 0202 electrical engineering, electronic engineering, information engineering, [INFO]Computer Science [cs], Threat prediction, Cyber Security, Ontology, Cyber Supply Chain, Machine Learning, Threat Prediction, Cyber Threat Intelligence, Systemvetenskap, informationssystem och informatik, Conceptualization, business.industry, Ontology, Node (networking), Security domain, 020201 artificial intelligence & image processing, State (computer science), Artificial intelligence, business, computer, Information Systems
Abstract

Part 13: Machine Learning; International audience; Cyber Supply Chain (CSC) security requires a secure integrated network among the sub-systems of the inbound and outbound chains. Adversaries are deploying various penetration and manipulation attacks on an CSC integrated network’s node. The different levels of integrations and inherent system complexities pose potential vulnerabilities and attacks that may cascade to other parts of the supply chain system. Thus, it has become imperative to implement systematic threats analyses and predication within the CSC domain to improve the overall security posture. This paper presents a unique approach that advances the current state of the art on CSC threat analysis and prediction by combining work from three areas: Cyber Threat Intelligence (CTI), Ontologies, and Machine Learning (ML). The outcome of our work shows that the conceptualization of cybersecurity using ontological theory provides clear mechanisms for understanding the correlation between the CSC security domain and enables the mapping of the ML prediction with 80% accuracy of potential cyberattacks and possible countermeasures.

Published
2021

36. ATOMIZATION MODELING USING SURFACE DENSITY AND STOCHASTIC FIELDS

Author

Giovanni Tretola, Aqeel Ahmed, Konstantina Vogiatzaki, Salvador Navarro-Martinez, Julien Reveillon, Benjamin Duret, François-Xavier Demoulin, Complexe de recherche interprofessionnel en aérothermochimie (CORIA), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Department of Mechanical Engineering [Imperial College London], Imperial College London, School of Computing, Engineering and Mathematics (Brighton), and University of Brighton

Subjects
Surface (mathematics), 020303 mechanical engineering & transports, Materials science, 0203 mechanical engineering, General Chemical Engineering, 02 engineering and technology, Mechanics, [PHYS.MECA.MEFL]Physics [physics]/Mechanics [physics]/Fluid mechanics [physics.class-ph], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2020

37. Applying Acceptance Requirements to Requirements Modeling Tools via Gamification: A Case Study on Privacy and Security

Author

Luca Piras, Paolo Giorgini, Federico Calabrese, Centre for Secure, Intelligent and Usable Systems [Brighton], University of Brighton, Department of Information Engineering and Computer Science (DISI), University of Trento [Trento], Jānis Grabis, Dominik Bork, TC 8, and WG 8.1

Subjects
Computer science, Acceptance requirements, Gamification, Goal modeling, Privacy requirements, Requirements Engineering, 02 engineering and technology, Requirements elicitation, Software, 0202 electrical engineering, electronic engineering, information engineering, [INFO]Computer Science [cs], Software system, Adaptation (computer science), Requirements analysis, Requirements engineering, business.industry, 05 social sciences, 050301 education, Risk analysis (engineering), Learning curve, 020201 artificial intelligence & image processing, business, 0503 education
Abstract

Part 8:Requirements Modeling; International audience; Requirements elicitation, analysis and modeling are critical activities for software success. However, software systems are increasingly complex, harder to develop due to an ever-growing number of requirements from numerous and heterogeneous stakeholders, concerning dozens of requirements types, from functional to qualitative, including adaptation, security and privacy, ethical, acceptance and more. In such settings, requirements engineers need support concerning such increasingly complex activities, and Requirements Engineering (RE) modeling tools have been developed for this. However, such tools, although effective, are complex, time-consuming and requiring steep learning curves. The consequent lack of acceptance and abandonment in using such tools, by engineers, paves the way to the application of RE techniques in a more error-prone, low-quality way, increasing the possibility to have failures in software systems delivered. In this paper, we identify main areas of lack of acceptance, affecting RE engineers, for such tools, and propose an approach for making modeling tools more effective in engaging the engineer in performing RE in a tool-based way, receiving adequate feedback and staying motivated to use modeling tools. This is accomplished by performing acceptance requirements analysis (through the Agon Framework) and using gamification to increase the engagement of engineers during the usage of RE modeling tools. Towards this end, we performed a case study, within the VisiOn European Project, for enhancing a tool for modeling privacy and security requirements. Our case study provides preliminary evidence that our approach supports in making RE modeling tools more engaging from the engineer perspective.

Published
2020

38. Laser-Deposited Carbon Aerogel Derived from Graphene Oxide Enables NO2-Selective Parts-per-Billion Sensing

Author

Christopher P. Ewels, Izabela Jurewicz, Peter Lynch, Sebastian Nufer, Ana M. Benito, Raul Arenal, Wolfgang K. Maser, Jonathan P. Salvage, Matthew Large, Nikos Tagmatarchis, Edgar Muñoz, Adam Brunton, Sean P. Ogilvie, Thomas Waters, Mario Pelaez-Fernandez, Alan B. Dalton, European Commission, Ministerio de Economía y Competitividad (España), Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), Gobierno de Aragón, University of Sussex, University of Brighton, University of Zaragoza - Universidad de Zaragoza [Zaragoza], University of Surrey (UNIS), Carbon Nanostructures and Nanotechnology Group (ICB-CSIC), Carbon Nanostructures and Nanotechnology Group, Fundación ARAID [Zaragoza, Spain], Diputación General de Aragón [Zaragoza, Spain], National Hellenic Research Foundation [Athens], Institut des Matériaux Jean Rouxel (IMN), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Ecole Polytechnique de l'Université de Nantes (EPUN), Université de Nantes (UN)-Université de Nantes (UN), and University of Oxford [Oxford]

Subjects
Microheater, Materials science, Annealing (metallurgy), Oxide, 02 engineering and technology, 010402 general chemistry, 7. Clean energy, 01 natural sciences, Selective, law.invention, chemistry.chemical_compound, Chemiresistors, Adsorption, Carbon aerogels, law, General Materials Science, Porosity, ComputingMilieux_MISCELLANEOUS, Nitrogen dioxide, Chemiresistor, Graphene, Aerogel, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Chemical engineering, chemistry, [PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci], 0210 nano-technology, Gas sensor
Abstract

4 figures., Laser-deposited carbon aerogel is a low-density porous network of carbon clusters synthesized using a laser process. A one-step synthesis, involving deposition and annealing, results in the formation of a thin porous conductive film which can be applied as a chemiresistor. This material is sensitive to NO2 compared to ammonia and other volatile organic compounds and is able to detect ultra-low concentrations down to at least 10 parts-per-billion. The sensing mechanism, based on the solubility of NO2 in the water layer adsorbed on the aerogel, increases the usability of the sensor in practically relevant ambient environments. A heating step, achieved in tandem with a microheater, allows the recovery to the baseline, making it operable in real world environments. This, in combination with its low cost and scalable production, makes it promising for Internet-of-Things air quality monitoring., This project has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement no. 642742. R.A. gratefully acknowledges the support from the Spanish Ministry of Economy and Competitiveness (MINECO) through Project Grant MAT2016-79776-P (AEI/FEDER, UE) and from the European Union H2020 programs “ESTEEM3” (823717), Flagship Graphene (881603), FLAG-ERA - Graphene (MICINN) GATES (PCI2018-093137). WKM and ABM further acknowledge the Gobierno de Aragon (Grupos Reconocidos DGA T03_17R (FEDER, UE) and T03_20R).

Published
2020
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39. Temperature measurements in a string of three closely spaced droplets before the start of puffing/micro-explosion: Experimental results and modelling

Author

Pavel A. Strizhak, Roman S. Volkov, Gullaume Castanet, R.M. Fedorenko, Sergei Sazhin, Dmitry Antonov, National Research Tomsk Polytechnic University, Laboratoire Énergies et Mécanique Théorique et Appliquée (LEMTA ), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Sir Harry Ricardo Laboratories, Advanced Engineering Centre, School of Computing, Engineering and Mathematics, University of Brighton, Samara National Research University (RUSSIA), National Research Tomsk Polytechnic University (project VIU-ISHFVP-60/2019), scholarships from the President of the Russian Federation (Grants SP-447.2021.1 and MN-7/2260), Université de Lorraine and the Institut Carnot Icéel for the CALICO (Combustion d’Aérosols LIquides Complexes) grant, and the Russian Science Foundation (Grant 21-19-00876)

Subjects
Fluid Flow and Transfer Processes, Materials science, [SPI.FLUID]Engineering Sciences [physics]/Reactive fluid environment, 020209 energy, Mechanical Engineering, Composite number, Nucleation, Time evolution, Evaporation, 02 engineering and technology, Mechanics, Condensed Matter Physics, Temperature measurement, Nusselt number, Diesel fuel, 020401 chemical engineering, 0202 electrical engineering, electronic engineering, information engineering, C++ string handling, 0204 chemical engineering, ComputingMilieux_MISCELLANEOUS
Abstract

The results of experimental and theoretical investigation of the mutual effects of three composite Diesel fuel/water droplets, one behind the other, on their puffing/micro-explosion are presented. The analysis is focused not only on finding the time instant when puffing/micro-explosion starts, but also on the investigation of time evolution of temperature at the water-fuel interface before the development of puffing/micro-explosion. The experimentally observed temperatures at the water-fuel interface are shown to increase almost linearly with time for the lead, middle and downstream droplets. Assuming that puffing/micro-explosion starts when the temperature at this interface reaches the water nucleation temperature, the values of the latter temperature as a function of the heating rate were found from the experimental data. The results are shown to be consistent with the earlier found correlation for this temperature for all three droplets. Time to puffing/micro-explosion is shown to decrease with increasing gas temperature; this time for the lead droplet is always shorter than that of the middle and downstream droplets, and the difference between them decreases as the distance between droplets increases. The experimental results are interpreted in terms of the previously developed model based on the assumption that the water sub-droplet is located exactly in the centre of the Diesel fuel droplet and that this process is triggered when the temperature at the water/fuel interface attains the water nucleation temperature. The effect of interaction between lead, middle and downstream droplets is considered via modifications to the Nusselt ( N u ) and Sherwood ( S h ) numbers for these droplets due to the interaction between them.

Published
2021

43. Puffing/micro-explosion of two closely spaced composite droplets in tandem: Experimental results and modelling

Author

Gullaume Castanet, Pavel A. Strizhak, Dmitry Antonov, R.M. Fedorenko, Sergei Sazhin, National Research Tomsk Polytechnic University, Laboratoire Énergies et Mécanique Théorique et Appliquée (LEMTA ), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Sir Harry Ricardo Laboratories, Advanced Engineering Centre, School of Computing, Engineering and Mathematics, University of Brighton, National Re-search Tomsk Polytechnic University (project VIU-ISHFVP-60/2019), Scholarships from the President of the Russian Federation (Grants SP-447.2021.1 and MN-7/2260), EPSRC, UK (Grant No. EP/M002608/1), and Royal Society (UK) (Grant No. IEC 192007)

Subjects
Fluid Flow and Transfer Processes, Materials science, Tandem, [SPI.FLUID]Engineering Sciences [physics]/Reactive fluid environment, Mechanical Engineering, Composite number, Flow (psychology), Evaporation, Nucleation, 02 engineering and technology, Mechanics, 021001 nanoscience & nanotechnology, Condensed Matter Physics, 01 natural sciences, Nusselt number, 010305 fluids & plasmas, 0103 physical sciences, Micro explosion, 0210 nano-technology, ComputingMilieux_MISCELLANEOUS
Abstract

The results of the experimental and theoretical investigations of the mutual effect on their puffing/micro-explosion of droplets in a flow, using an example of two closely spaced droplets in tandem, are presented. It is shown that the time to puffing/micro-explosion ( τ p ) of the lead droplet is always shorter than that of the downstream droplet, and the difference between them decreases with increasing distance between droplets divided by their initial diameters ( 2 R d 0 ). It is shown that the τ p of both droplets increases with increasing R d 0 . The experimental results are interpreted in terms of the previously developed model for fuel/water droplet puffing/micro-explosion, based on the assumptions that the water sub-droplet is located in the centre of the fuel droplet and that this process is triggered when the temperature at the water/fuel interface reaches the water nucleation temperature. The effect of interaction between the lead and downstream droplets is taken into account via modifications to the Nusselt and Sherwood numbers for these droplets using the results of numerical calculations. Both experimentally observed and predicted values of τ p are shown to increase with increasing R d 0 . They are shown to be longer for the downstream droplets than for the lead droplets. The experimentally observed differences in τ p for the lead and downstream droplets are close to the predicted differences.

Published
2021

45. A multiscale stratigraphic investigation of the context of StW 573 ‘Little Foot’ and Member 2, Sterkfontein Caves, South Africa

Author

Ronald J. Clarke, Kristian J. Carlson, Kathleen Kuman, George M. Leader, Juliet McClymont, Robin H. Crompton, Dominic Stratford, Richard Maire, Tea Jashashvili, Travis Rayne Pickering, Jason L. Heaton, Amélie Beaudet, Laurent Bruxelles, Institut national de recherches archéologiques préventives (Inrap), Institut Français en Afrique du Sud (IFAS), Institut Français en Afrique du Sud, University of the Witwatersrand [Johannesburg] (WITS), Passages, Centre National de la Recherche Scientifique (CNRS)-Université Bordeaux Montaigne-Université de Pau et des Pays de l'Adour (UPPA)-Ministère de la Culture et de la Communication (MCC)-Université de Bordeaux (UB), Birmingham-Southern College, University of Pretoria - Department of Anatomy, University of Liverpool, University of Brighton, The College of New Jersey (TCNJ), and Université de Bordeaux (UB)-Ministère de la Culture et de la Communication (MCC)-Université de Pau et des Pays de l'Adour (UPPA)-Université Bordeaux Montaigne-Centre National de la Recherche Scientifique (CNRS)

Subjects
Member 2, 010506 paleontology, Geologic Sediments, Sterkfontein, Taphonomy, [SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, Stratigraphy, Australopithecus, Context (language use), 01 natural sciences, Paleontology, South Africa, Cave, Animals, 0601 history and archaeology, Sedimentology, Ecology, Evolution, Behavior and Systematics, Cave geology, 0105 earth and related environmental sciences, geography, 060101 anthropology, geography.geographical_feature_category, biology, Fossils, Hominidae, 06 humanities and the arts, biology.organism_classification, Caves, Archaeology, Anthropology, Clastic rock, Facies, StW 573, Geology
Abstract

International audience; The Sterkfontein Caves is currently the world's richest Australopithecus-bearing site. Included in Sterkfontein's hominin assemblage is StW 573 (‘Little Foot’), a near-complete Australopithecus skeleton discovered in Member 2 in the Silberberg Grotto. Because of its importance to the fossil hominin record, the geological age of StW 573 has been the subject of significant debate. Three main hypotheses have been proposed regarding the formation and age of Member 2 and by association StW 573. The first proposes that Member 2 (as originally defined in the type section in the Silberberg Grotto) started to accumulate at around 2.58 Ma and that the unit is contained within the Silberberg Grotto. The second proposes that Member 2 started forming before 3.67 ± 0.16 Ma and that the deposit extends into the Milner Hall and close to the base of the cave system. The third proposes a ‘two-stage burial scenario’, in which some sediments and StW 573 represent a secondary and mixed-age accumulation reworked from a higher cave. The stratigraphic and sedimentological implications of these hypotheses are tested here through the application of a multiscale investigation of Member 2, with reference to the taphonomy of the StW 573 skeleton. The complete infilling sequence of Member 2 is described across all exposures of the deposit in the Silberberg Grotto and into the Milner Hall. Sediments are generally stratified and conformably deposited in a sequence of silty sands eroded from well-developed lateritic soils on the landscape surface. Voids, clasts and bioclasts are organized consistently across and through Member 2 conforming with the underlying deposit geometry, indicating gradual deposit accretion with no distinct collapse facies evident and only localized intra-unit postdepositional modification. The stratigraphy and sedimentology of Member 2 support a simple single-stage accumulation process of Member 2 and a primary association between the sediments of Member 2 and the StW 573 ‘Little Foot’ skeleton.

Published
2019

46. Conference Report: Carnival of Invention

Author

Fennessy, Jenny, Woods, Sandie, Johnson, Helen, Rivas, Carol, Norbury, David, Almeida-Harvey, Isilda, Moriarty, Jessica, Wimpenny, Katherine, Bushell, Kerensa, Blake, Polly, and Collaborative Poetics Network, The University of Brighton

Subjects
kollaborative Poetik, kunstbasierte Forschung, Kommunikation, qualitative Forschung, soziale Veränderung, collaborative poetics, arts-based research, communication, qualitative research, social change, Psychology, Arts Based Research
Abstract

In diesem Tagungsbericht stellen wir den 1. "Carnival of Invention" vor, der vom Collaborative Poetics Network am 15. Juni 2018 an der University of Brighton, England, ausgerichtet wurde. Kollaborative Poetik ist ein kunstbasiertes Verfahren, bei dem Künstler/innen, Akademiker/innen und Lai/innen zusammenarbeiten und ihr Wissen miteinander mit dem Ziel sozialer Veränderungen austauschen. Während des Carnival nahmen über 40 Beitragende aus unterschiedlichsten Ländern an Workshops, Präsentationen, Installationen usw. teil. In diesem Beitrag stellen wir die behandelten Themen und die in interaktiven und empirischen Sessions genutzten Medien vor. Wir zeigen, in welcher Weise die Veranstaltung durch die Entwicklung, Analyse und Kommunikation reicher Datensets zur Veranschaulichung der Benefits kunstbasierter Verfahren beigetragen hat und enden mit einer abschließenden Reflektion und Evaluation des Events., In this report we present a reflection on the Collaborative Poetics Network's first "Carnival of Invention" which was held on 15th June 2018 at the University of Brighton, England. Collaborative poetics is an arts-based research method that brings together expertise from artists, academics, and community participants, to share knowledge and promote social change through engaging and accessible ways. On the day of the Carnival over 40 contributors from around the world came to participate in a series of workshops, presentations, installations and displays. In this article we outline the themes addressed on the day and the media utilized in these interactive and experiential sessions. We argue that this event supported the benefits of arts-based research in developing, analyzing, and communicating rich data sets. Finally, we provide evaluation and reflections from the event (including in haiku, a traditional Japanese form of poetry), in an attempt to creatively capture the events of the day.

Published
2019

47. Mapping the height of heterogeneous vegetation from UAV-borne visible images and DSM

Author

Grimaldi, Juliette, Helen, F, Pelletier, Charlotte, Bustillo, Vincent, Houet, Thomas, Fonctionnement et conduite des systèmes de culture tropicaux et méditerranéens (UMR SYSTEM), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Centre International de Hautes Etudes Agronomiques Méditerranéennes - Institut Agronomique Méditerranéen de Montpellier (CIHEAM-IAMM), Centre International de Hautes Études Agronomiques Méditerranéennes (CIHEAM)-Centre International de Hautes Études Agronomiques Méditerranéennes (CIHEAM)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Faculty of Science and Engineering, University of Brighton, Monash University, Centre d'études spatiales de la biosphère (CESBIO), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS), Littoral, Environnement, Télédétection, Géomatique (LETG - Rennes), Littoral, Environnement, Télédétection, Géomatique UMR 6554 (LETG), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Université d'Angers (UA)-Université de Nantes (UN)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Brest (UBO)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Université de Caen Normandie (UNICAEN), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), and Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)

Subjects
[SDV.SA]Life Sciences [q-bio]/Agricultural sciences, upervised classifications, [SHS.ENVIR]Humanities and Social Sciences/Environmental studies, UAV, Digital Surface Model, [SHS.GEO]Humanities and Social Sciences/Geography, Digital terrain Model, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, ComputingMilieux_MISCELLANEOUS, top canopy height
Abstract

International audience

Published
2019

48. Prominence of Pairing in Inclusive ($p$ ,2$p$) and ($p$, $pn$) Cross Sections from Neutron-Rich Nuclei

Author

Paul, N., Obertelli, A., Bertulani, C, Corsi, A., Doornenbal, P., Rodriguez-Sanchez, J. L., Authelet, G., Baba, H., Calvet, D., Chateau, F., Chen, S., Delbart, A., Gheller, J.-M., Giganon, A., Gillibert, A., Isobe, T., Lapoux, V., Matsushita, M., Momiyama, S., Motobayashi, T., Niikura, M., Otsu, H., Peron, C., Peyaud, A., Pollacco, E., Rousse, J.-Y., Sakurai, H., Santamaria, C., Sasano, M., Shiga, Y., Steppenbeck, D., Takeuchi, S., Taniuchi, R., Uesaka, T., Wang, H., Yoneda, K., Ando, T., Arici, T., Blazhev, A., Browne, F., Bruce, A., Carroll, R., Chung, L. X., Cortés, M., Dewald, M., Ding, B., Dombradi, Zs, Flavigny, F., Franchoo, S., Giacoppo, F., Górska, M., Gottardo, A., Hadynska-Klek, K., Korkulu, Z., Koyama, S., Kubota, Y., Jungclaus, A., Lee, J., Lettmann, M., Linh, B, Liu, J., Liu, Z., Lizarazo, C., Louchart, C., Lozeva, Radomira, Matsui, K., Miyazaki, T., Moschner, K., Nagamine, S., Nakatsuka, N., Nita, C., Nishimura, S., Nobs, C., Olivier, L., Ota, S., Patel, Z., Podolyák, Zs, Rudigier, M., Sahin, E., Saito, T., Shand, C., Söderström, P.-A, Stefan, I, Sumikama, T., Suzuki, D., Orlandi, R., Vaquero, V., Werner, V., Wimmer, K., Wu, J., Xu, Z., Dombradi, Zs., Podolyak, Zs., Stefan, G., Vajta, Zs., Département de Physique Nucléaire (ex SPhN) (DPHN), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, RIKEN Nishina Center for Accelerator-Based Science [Wako] (RIKEN RNC), RIKEN - Institute of Physical and Chemical Research [Japon] (RIKEN), Technische Universität Darmstadt (TU Darmstadt), Texas A&M University–Commerce, Helmholtz Centre for Heavy Ion Research (GSI), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Département d'Electronique, des Détecteurs et d'Informatique pour la Physique (ex SEDI) (DEDIP), Département d'Astrophysique, de physique des Particules, de physique Nucléaire et de l'Instrumentation Associée (DAPNIA), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Centre for Nuclear Study, University of Tokyo (CNS), The University of Tokyo (UTokyo), Department of Applied Physics, The University of Tokyo, Département d'Ingénierie des Systèmes (ex SIS) (DIS), Rikkyo University [Tokyo], Universität zu Köln, School of Computing, Engineering and Mathematics (Brighton), University of Brighton, University of Surrey (UNIS), Institute for Nuclear Science and Technique, VINATOM, Institut für Kernphysik der Universität zu Köln, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China (IMP), Institute for Nuclear Research [Budapest] (ATOMKI), Hungarian Academy of Sciences (MTA), Institut de Physique Nucléaire d'Orsay (IPNO), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), University of Oslo (UiO), Spanish National Research Council [Madrid] (CSIC), City University of Hong Kong [Hong Kong] (CUHK), Centre de Sciences Nucléaires et de Sciences de la Matière (CSNSM), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Kyoto University [Kyoto], IFIN-HH, Oslo University Hospital [Oslo], Tohoku University [Sendai], Japan Atomic Energy Agency [Ibaraki] (JAEA), Department of Physics, University of Tokyo, Bunkyo, Tokyo, European Project: 258567,EC:FP7:ERC,ERC-2010-StG_20091028,MINOS(2010), Technische Universität Darmstadt - Technical University of Darmstadt (TU Darmstadt), Universität zu Köln = University of Cologne, and Kyoto University

Subjects
[PHYS]Physics [physics], Nuclear Theory, Physics::Accelerator Physics, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], Nuclear Experiment
Abstract

International audience; Fifty-five inclusive single nucleon-removal cross sections from medium mass neutron-rich nuclei impinging on a hydrogen target at $\sim$250 MeV=nucleon are measured at the RIKEN Radioactive Isotope Beam Factory. Systematically higher cross sections are found for proton removal from nuclei with an even number of protons as compared to odd-proton number projectiles for a given neutron separation energy. Neutron removal cross sections display no even-odd splitting, contrary to nuclear cascade model predictions. Both effects are understood through simple considerations of neutron separation energies and bound state level densities originating in pairing correlations in the daughter nuclei. These conclusions are supported by comparison with semimicroscopic model predictions, highlighting the enhanced role of lowlying level densities in nucleon-removal cross sections from loosely bound nuclei

Published
2019

49. Unprecedented Thiacalixarene Fucoclusters as Strong Inhibitors of Ebola cis-Cell Infection and HCMV-gB Glycoprotein/DC-SIGN C-type Lectin Interaction

Author

Franck Fieschi, Franck Halary, Mohammed Benazza, Peter J. Cragg, Coraline Chéneau, Khouloud Chakroun, Joanna Luczkowiak, Vanessa Porkolab, Rafael Delgado, Rym Abidi, David Lesur, Marwa Taouai, Laboratoire de Glycochimie, des Antimicrobiens et des Agro-ressources - UMR CNRS 7378 (LG2A ), Université de Picardie Jules Verne (UPJV)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut de biologie structurale (IBS - UMR 5075 ), Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche en Transplantation et Immunologie (U1064 Inserm - CRTI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Laboratorio de Microbiología Molecular, Instituto de Investigación Sanitaria Hospital 12 de Octubre [Madrid, Spain], Laboratoire d'Application de la Chimie aux Ressources et Substances Naturelles de l'Environnement, Faculté des Sciences de Bizerte [Université de Carthage], Université de Carthage - University of Carthage-Université de Carthage - University of Carthage, School of Pharmacy & Biomolecular Sciences, University of Brighton, Brighton BN2 4GJ, U.K, Institut de transplantation urologie-néphrologie (ITUN), Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes), Dendritic cells and immunoregulation in transplantation and immunopathology (Team 1 - U1064 Inserm - CRTI), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)

Subjects
Biomedical Engineering, Pharmaceutical Science, Bioengineering, Receptors, Cell Surface, 02 engineering and technology, Plasma protein binding, medicine.disease_cause, 01 natural sciences, Jurkat cells, Antiviral Agents, Jurkat Cells, Viral Envelope Proteins, C-type lectin, medicine, Humans, Avidity, Lectins, C-Type, Pharmacology, chemistry.chemical_classification, Ebola virus, biology, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], 010405 organic chemistry, Organic Chemistry, Dendritic cell, Hemorrhagic Fever, Ebola, 021001 nanoscience & nanotechnology, Virology, 3. Good health, 0104 chemical sciences, DC-SIGN, chemistry, biology.protein, Calixarenes, 0210 nano-technology, Glycoprotein, Cell Adhesion Molecules, Biotechnology, Protein Binding
Abstract

International audience; Glycan-protein interactions control numerous biological events from cell-cell recognition and signaling to pathogen host cell attachment for infections. To infect cells, some viruses bind to immune cells with the help of DC-SIGN (dendritic cell [DC]-specific ICAM3-grabbing nonintegrin) C-type lectin expressed on dendritic and macrophage cell membranes, via their envelope protein. Prevention of this infectious interaction is a serious therapeutic option. Here, we describe the synthesis of the first water-soluble tetravalent fucocluster pseudopeptide-based 1,3-alternate thiacalixarenes as viral antigen mimics designed for the inhibition of DC-SIGN, to prevent viral particle uptake. Their preparation exploits straightforward convergent strategies involving one-pot Ugi four-component (Ugi-4CR) and azido-alkyne click chemistry reactions as key steps. Surface plasmon resonance showed strong inhibition of DC-SIGN interaction properties by tetravalent ligands designed with high relative potencies and β avidity factors. All ligands block DC-SIGN active sites at nanomolar IC50 preventing cis-cell infection by Ebola viral particles pseudotyped with EBOV glycoprotein (Zaire species of Ebola virus) on Jurkat cells that express DC-SIGN. In addition, we observed strong inhibition of DC-SIGN/human cytomegalovirus (HCMV)-gB recombinant glycoprotein interaction. This finding opens the way to the simple development of new models of water-soluble glycocluster-based thia-calixarenes with wide-ranging antimicrobial activities.

Published
2019

50. Teachers’ Perceptions of Using Incentives in State Examinations to Increase the uptake of Higher Level Mathematics

Author

Prendergast, Mark, Treacy, Paraic, O'Meara, Niamh, Trinity College Dublin, University of Brighton, University of Limerick (UL), Utrecht University, Uffe Thomas Jankvist, Marja van den Heuvel-Panhuizen, Michiel Veldhuis, and Veldhuis, Michiel

Subjects
teacher perceptions, Education policy, incentives, [SHS.EDU]Humanities and Social Sciences/Education, [SHS.EDU] Humanities and Social Sciences/Education, state examinations, [MATH] Mathematics [math], [MATH]Mathematics [math], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2019

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