1. A Multi-Stream Convolutional Neural Network for Classification of Progressive MCI in Alzheimer’s Disease Using Structural MRI Images
- Author
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Mona Ashtari-Majlan, Abbas Seifi, Mohammad Mahdi Dehshibi, Universitat Oberta de Catalunya. Estudis d'Informàtica, Multimèdia i Telecomunicació, and Amirkabir University of Technology
- Subjects
FOS: Computer and information sciences ,Computer Science - Machine Learning ,mapa en forma de cerebro ,Computer Vision and Pattern Recognition (cs.CV) ,Computer Science - Computer Vision and Pattern Recognition ,convolutional neural network ,enfermedad de Alzheimer ,Health Informatics ,transfer learning ,prueba estadística multivariante ,behavioral disciplines and activities ,Machine Learning (cs.LG) ,red neuronal convolucional ,Health Information Management ,Alzheimer Disease ,malaltia d'Alzheimer ,mental disorders ,FOS: Electrical engineering, electronic engineering, information engineering ,Humans ,Cognitive Dysfunction ,Electrical and Electronic Engineering ,Alzheimer, Malaltia d ,xarxa neuronal convolucional ,Image and Video Processing (eess.IV) ,Electrical Engineering and Systems Science - Image and Video Processing ,Alzheimer's disease ,brain-shaped map ,test estadístic multivariant ,Magnetic Resonance Imaging ,Computer Science Applications ,mapa en forma de cervell ,transferir l'aprenentatge ,transferir el aprendizaje ,Early Diagnosis ,Neural Networks, Computer ,multivariate statistical test ,Alzheimer’s disease - Abstract
Early diagnosis of Alzheimer's disease and its prodromal stage, also known as mild cognitive impairment (MCI), is critical since some patients with progressive MCI will develop the disease. We propose a multi-stream deep convolutional neural network fed with patch-based imaging data to classify stable MCI and progressive MCI. First, we compare MRI images of Alzheimer's disease with cognitively normal subjects to identify distinct anatomical landmarks using a multivariate statistical test. These landmarks are then used to extract patches that are fed into the proposed multi-stream convolutional neural network to classify MRI images. Next, we train the architecture in a separate scenario using samples from Alzheimer's disease images, which are anatomically similar to the progressive MCI ones and cognitively normal images to compensate for the lack of progressive MCI training data. Finally, we transfer the trained model weights to the proposed architecture in order to fine-tune the model using progressive MCI and stable MCI data. Experimental results on the ADNI-1 dataset indicate that our method outperforms existing methods for MCI classification, with an F1-score of 85.96%.
- Published
- 2022
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