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1. Finger-Based Manipulation in Immersive Spaces and the Real World

Author: INRIA Sophia Antipolis - GRAPHDECO ; INRIA Sophia Antipolis (INRIA Sophia Antipolis) ; INRIA - INRIA, Laboratoire de Recherche en Informatique (LRI) ; CNRS - Université Paris-Sud - Paris 11 (UP11), IN-SITU (INRIA Saclay - Ile de France) ; CNRS - INRIA - Université Paris-Sud - Paris 11 (UP11), This work was supported in part by the Regional Council of Provence Alpes-Côte d’Azur and the EU project VERVE., IEEE, European Project : 288914, ICT, FP7-ICT-2011-7, VERVE(2011), Chapoulie, Emmanuelle, Tsandilas, Theophanis, Oehlberg, Lora, Mackay, Wendy E., Drettakis, George, INRIA Sophia Antipolis - GRAPHDECO ; INRIA Sophia Antipolis (INRIA Sophia Antipolis) ; INRIA - INRIA, Laboratoire de Recherche en Informatique (LRI) ; CNRS - Université Paris-Sud - Paris 11 (UP11), IN-SITU (INRIA Saclay - Ile de France) ; CNRS - INRIA - Université Paris-Sud - Paris 11 (UP11), This work was supported in part by the Regional Council of Provence Alpes-Côte d’Azur and the EU project VERVE., IEEE, European Project : 288914, ICT, FP7-ICT-2011-7, VERVE(2011), Chapoulie, Emmanuelle, Tsandilas, Theophanis, Oehlberg, Lora, Mackay, Wendy E., and Drettakis, George
Abstract: International audience, Immersive environments that approximate natural interaction with physical 3D objects are designed to increase the user’s sense of presence and improve performance by allowing users to transfer existing skills and expertise from real to virtual environments. However, limitations of current Virtual Reality technologies, e.g., low-fidelity real-time physics simulations and tracking problems, make it difficult to ascertain the full potential of finger-based 3D manipulation techniques. This paper decomposes 3D object manipulation into the component movements, taking into account both physical constraints and mechanics. We fabricate five physical devices that simulate these movements in a measurable way under experimental conditions. We then implement the devices in an immersive environment and conduct an experiment to evaluate direct finger-based against ray-based object manipulation. The key contribution of this work is the careful design and creation of physical and virtual devices to study physics-based 3D object manipulation in a rigorous manner in both real and virtual setups.

2. Distributed Monitoring with Collaborative Prediction

Author: Laboratoire de Recherche en Informatique (LRI) ; CNRS - Université Paris-Sud - Paris 11 (UP11), TAO (INRIA Saclay - Ile de France) ; CNRS - INRIA - Université Paris-Sud - Paris 11 (UP11), Centre de recherche en applications et traitement de l'image pour la santé (CREATIS) ; CNRS - INSERM - Hospices Civils de Lyon - Université Claude Bernard Lyon 1 (UCBL) - Institut National des Sciences Appliquées (INSA), France Grilles, Chinese Scholarship council, European Project : 261323, INFRA, FP7-INFRASTRUCTURES-2010-2, EGI-INSPIRE(2010), Feng, Dawei, Germain-Renaud, Cecile, Glatard, Tristan, Laboratoire de Recherche en Informatique (LRI) ; CNRS - Université Paris-Sud - Paris 11 (UP11), TAO (INRIA Saclay - Ile de France) ; CNRS - INRIA - Université Paris-Sud - Paris 11 (UP11), Centre de recherche en applications et traitement de l'image pour la santé (CREATIS) ; CNRS - INSERM - Hospices Civils de Lyon - Université Claude Bernard Lyon 1 (UCBL) - Institut National des Sciences Appliquées (INSA), France Grilles, Chinese Scholarship council, European Project : 261323, INFRA, FP7-INFRASTRUCTURES-2010-2, EGI-INSPIRE(2010), Feng, Dawei, Germain-Renaud, Cecile, and Glatard, Tristan
Abstract: International audience, Isolating users from the inevitable faults in large distributed systems is critical to Quality of Experience. We formulate the problem of probe selection for fault prediction based on end-to-end probing as a Collaborative Prediction (CP) problem. On an extensive experimental dataset from the EGI grid, the combination of the Maximum Margin Matrix Factor- ization approach to CP and Active Learning shows excellent performance, reducing the number of probes typically by 80% to 90%.

3. Efficient fault monitoring with Collaborative Prediction

Author: Laboratoire de Recherche en Informatique (LRI) ; CNRS - Université Paris-Sud - Paris 11 (UP11), TAO (INRIA Saclay - Ile de France) ; CNRS - INRIA - Université Paris-Sud - Paris 11 (UP11), Centre de recherche en applications et traitement de l'image pour la santé (CREATIS) ; CNRS - INSERM - Hospices Civils de Lyon - Université Claude Bernard Lyon 1 (UCBL) - Institut National des Sciences Appliquées (INSA), France Grilles, European Project : 261323, INFRA, FP7-INFRASTRUCTURES-2010-2, EGI-INSPIRE(2010), Feng, Dawei, Germain-Renaud, Cecile, Glatard, Tristan, Laboratoire de Recherche en Informatique (LRI) ; CNRS - Université Paris-Sud - Paris 11 (UP11), TAO (INRIA Saclay - Ile de France) ; CNRS - INRIA - Université Paris-Sud - Paris 11 (UP11), Centre de recherche en applications et traitement de l'image pour la santé (CREATIS) ; CNRS - INSERM - Hospices Civils de Lyon - Université Claude Bernard Lyon 1 (UCBL) - Institut National des Sciences Appliquées (INSA), France Grilles, European Project : 261323, INFRA, FP7-INFRASTRUCTURES-2010-2, EGI-INSPIRE(2010), Feng, Dawei, Germain-Renaud, Cecile, and Glatard, Tristan
Abstract: National audience, Isolating users from the inevitable faults in large distributed systems is critical to Quality of Experience. We formulate the problem of probe selection for fault prediction based on end-to-end probing as a Collaborative Prediction (CP) problem. On an extensive experimental dataset from the EGI grid, the combination of the Maximum Margin Matrix Factorization approach to CP and Active Learning shows excellent performance, reducing the number of probes typically by 80% to 90%.

4. Packet-based dynamic control for nonlinear networked systems

Author: Centro di ricerca E. Piaggio ; Università di Pisa, Division Systèmes ; Laboratoire des signaux et systèmes (L2S) ; Université Paris-Sud - Paris 11 (UP11) - SUPELEC - UMR8506 CNRS - Université Paris-Sud - Paris 11 (UP11) - SUPELEC - UMR8506 CNRS, Interdep. Research Center "E. Piaggio" ; Università di Pisa, Istituto Italiano di Tecnologia (IIT) ; Istituto Italiano di Tecnologia, European Project : 257462, ICT, FP7-ICT-2009-5, HYCON2(2010), Falasca, Stefano, Gamba, Massimiliano, Greco, Luca, Chaillet, Antoine, Bicchi, Antonio, Centro di ricerca E. Piaggio ; Università di Pisa, Division Systèmes ; Laboratoire des signaux et systèmes (L2S) ; Université Paris-Sud - Paris 11 (UP11) - SUPELEC - UMR8506 CNRS - Université Paris-Sud - Paris 11 (UP11) - SUPELEC - UMR8506 CNRS, Interdep. Research Center "E. Piaggio" ; Università di Pisa, Istituto Italiano di Tecnologia (IIT) ; Istituto Italiano di Tecnologia, European Project : 257462, ICT, FP7-ICT-2009-5, HYCON2(2010), Falasca, Stefano, Gamba, Massimiliano, Greco, Luca, Chaillet, Antoine, and Bicchi, Antonio
Abstract: International audience, The possibility to remotely control a plant through a communication network offers strong advantages in terms of installation, flexibility, and maintenance. These advantages come at the price of specific challenges due to the format of the transmitted data, the network nodes scheduling, and the inherent delays. To address these obstacles, we have recently developed a control methodology that exploits the packetized nature of the transmitted data by relying on a model-based prediction of the control signal to be applied. However, this methodology was limited to static controllers. Dynamic control laws indeed require a more careful synchronization between the plant and its remote model. This paper aims at filling this gap by exploiting the transmission of the measurements history, rather than their instantaneous value only.

5. The ARCOMEM Architecture for Social- and Semantic-Driven Web Archiving

Author: OAK (INRIA Saclay - Ile de France) ; Université Paris-Sud - Paris 11 (UP11) - INRIA - CNRS, Laboratoire de Recherche en Informatique (LRI) ; CNRS - Université Paris-Sud - Paris 11 (UP11), Leibniz Universität Hannover [Hannover] (LUH) ; Leibniz Universität Hannover, National Technical University of Athens [Athens] (NTUA) ; National Technical University of Athens, Department of Informatics [Athens] (CS-AUEB), Laboratoire Traitement et Communication de l'Information (LTCI) ; Télécom ParisTech - Institut Mines-Télécom - CNRS, Laboratoire BioGeMME (Biologie et Génétique des Mammifères Marins dans leur Environnement) (BioGeMME) ; Université européenne de Bretagne (UEB) - Université de Bretagne Occidentale (UBO), European Project : 270239, ICT, FP7-ICT-2009-6, ARCOMEM(2010), Cautis, Bogdan, Risse, Thomas, Demidova, Elena, Dietze, Stefan, Peters, Wim, Papailiou, Nikolaos, Doka, Katerina, Stavrakas, Yannis, Plachouras, Vassilis, Senellart, Pierre, Carpentier, Florent, Mantric, Amin, Siehndel, Patrick, Spiliotopoulos, Dimitris, OAK (INRIA Saclay - Ile de France) ; Université Paris-Sud - Paris 11 (UP11) - INRIA - CNRS, Laboratoire de Recherche en Informatique (LRI) ; CNRS - Université Paris-Sud - Paris 11 (UP11), Leibniz Universität Hannover [Hannover] (LUH) ; Leibniz Universität Hannover, National Technical University of Athens [Athens] (NTUA) ; National Technical University of Athens, Department of Informatics [Athens] (CS-AUEB), Laboratoire Traitement et Communication de l'Information (LTCI) ; Télécom ParisTech - Institut Mines-Télécom - CNRS, Laboratoire BioGeMME (Biologie et Génétique des Mammifères Marins dans leur Environnement) (BioGeMME) ; Université européenne de Bretagne (UEB) - Université de Bretagne Occidentale (UBO), European Project : 270239, ICT, FP7-ICT-2009-6, ARCOMEM(2010), Cautis, Bogdan, Risse, Thomas, Demidova, Elena, Dietze, Stefan, Peters, Wim, Papailiou, Nikolaos, Doka, Katerina, Stavrakas, Yannis, Plachouras, Vassilis, Senellart, Pierre, Carpentier, Florent, Mantric, Amin, Siehndel, Patrick, and Spiliotopoulos, Dimitris
Abstract: International audience

6. Corroborating Information from Disagreeing Views

Author: LEO (INRIA Saclay - Ile de France) ; Université Paris-Sud - Paris 11 (UP11) - INRIA - CNRS, Rutgers, The State University of New Jersey [New Brunswick] (RUTGERS) ; Rutgers, The State University of New Jersey, Télécom ParisTech, This work has been partially funded by the European Research Council under the European Community's Seventh Framework Programme (FP7/2007-2013) / ERC grant Webdam, agreement 226513. http://webdam.inria.fr/, European Project : 226513, ERC, ERC-2008-AdG, WEBDAM(2008), Galland, Alban, Abiteboul, Serge, Marian, Amélie, Senellart, Pierre, LEO (INRIA Saclay - Ile de France) ; Université Paris-Sud - Paris 11 (UP11) - INRIA - CNRS, Rutgers, The State University of New Jersey [New Brunswick] (RUTGERS) ; Rutgers, The State University of New Jersey, Télécom ParisTech, This work has been partially funded by the European Research Council under the European Community's Seventh Framework Programme (FP7/2007-2013) / ERC grant Webdam, agreement 226513. http://webdam.inria.fr/, European Project : 226513, ERC, ERC-2008-AdG, WEBDAM(2008), Galland, Alban, Abiteboul, Serge, Marian, Amélie, and Senellart, Pierre
Abstract: International audience, We consider a set of views stating possibly conflicting facts. Negative facts in the views may come, e.g., from functional dependencies in the underlying database schema. We want to predict the truth values of the facts. Beyond simple methods such as voting (typically rather accurate), we explore techniques based on ``corroboration'', i.e., taking into account trust in the views. We introduce three fixpoint algorithms corresponding to different levels of complexity of an underlying probabilistic model. They all estimate both truth values of facts and trust in the views. We present experimental studies on synthetic and real-world data. This analysis illustrates how and in which context these methods improve corroboration results over baseline methods. We believe that corroboration can serve in a wide range of applications such as source selection in the semantic Web, data quality assessment or semantic annotation cleaning in social networks. This work sets the bases for a wide range of techniques for solving these more complex problems.

7. Algorithme exact et approché pour le calcul de l'hyperbolicité d'un graphe

Author: Laboratoire de Recherche en Informatique (LRI) ; CNRS - Université Paris-Sud - Paris 11 (UP11), COATI (Inria Sophia Antipolis / Laboratoire I3S) ; CNRS - INRIA - Université Nice Sophia Antipolis (UNS), Nisse, Nicolas and Rousseau, Franck and Busnel, Yann, European Project : 258307, ICT, FP7-ICT-2009-5, EULER(2010), Cohen, Nathann, Coudert, David, Lancin, Aurélien, Laboratoire de Recherche en Informatique (LRI) ; CNRS - Université Paris-Sud - Paris 11 (UP11), COATI (Inria Sophia Antipolis / Laboratoire I3S) ; CNRS - INRIA - Université Nice Sophia Antipolis (UNS), Nisse, Nicolas and Rousseau, Franck and Busnel, Yann, European Project : 258307, ICT, FP7-ICT-2009-5, EULER(2010), Cohen, Nathann, Coudert, David, and Lancin, Aurélien
Abstract: Page 1-4, International audience, Nous proposons un algorithme simple et efficace pour calculer l'hyperbolicité de grands graphes dont la complexité temporelle est fonction de la distribution des plus courts chemins dans les composantes biconnexes du graphe et de la valeur de l'hyperbolicité. Nous montrons également comment réduire la taille de l'instance en utilisant une décomposition par des cliques-séparatrices. L'algorithme peut de plus être utilisé pour fournir une approximation de l'hyperbolicité à un facteur multiplicatif ou une constante additive donnés. Nous évaluons les performances de notre algorithme sur des cartes des systèmes autonomes de l'Internet (CAIDA et DIMES).

8. Vector-based active surfaces for segmentation of dynamic PET images

Author: Imagerie et cerveau ; INSERM - Université François Rabelais - Tours - CNRS, Service Hospitalier Frédéric Joliot (SHFJ) ; CEA, Imagerie et Modélisation en Neurobiologie et Cancérologie (IMNC) ; Université Paris-Sud - Paris 11 (UP11) - IN2P3 - Université Paris Diderot - Paris 7 (UP7) - CNRS, European Project : 278850, HEALTH, FP7-HEALTH-2011-two-stage, INMIND(2012), Jaouen, Vincent, Gonzalez, Paulo, Stute, Simon, GUILLOTEAU, Denis, Buvat, Irène, Tauber, Clovis, Imagerie et cerveau ; INSERM - Université François Rabelais - Tours - CNRS, Service Hospitalier Frédéric Joliot (SHFJ) ; CEA, Imagerie et Modélisation en Neurobiologie et Cancérologie (IMNC) ; Université Paris-Sud - Paris 11 (UP11) - IN2P3 - Université Paris Diderot - Paris 7 (UP7) - CNRS, European Project : 278850, HEALTH, FP7-HEALTH-2011-two-stage, INMIND(2012), Jaouen, Vincent, Gonzalez, Paulo, Stute, Simon, GUILLOTEAU, Denis, Buvat, Irène, and Tauber, Clovis
Abstract: International audience, Dynamic PET imaging enables the study of radiotracers concentration kinetics along time. However, PET images suffer from limited spatial resolution, low signal-to-noise ratio, and time dependent contrast between tissues, making segmentation of biological volumes difficult. Deformable models are of great interest due to their inherent boundary continuity, but their applications to PET images still remains challenging due to high sensitivity to noise. To address these limitations, we propose a method to perform 3-D+time dynamic PET image segmentation using parametric active surfaces based on a gradient of the vectorial image. This method takes advantage of both spatial and temporal consistency of the signal along the acquisition. We validate our method using GATE Monte Carlo simulations and compare it with single frame based active surface models. We show significant improvement of several figures of merit.

9. The Hidden Web, XML and Semantic Web: A Scientific Data Management Perspective

Author: LEO (INRIA Saclay - Ile de France) ; Université Paris-Sud - Paris 11 (UP11) - INRIA - CNRS, Montclair State University ; Montclair State University, Queensland University of Technology [Brisbane] (QUT) ; Queensland University ot Technology, Télécom ParisTech, European Project : 226513, ERC, ERC-2008-AdG, WEBDAM(2008), Suchanek, Fabian, Varde, Aparna, Nayak, Richi, Senellart, Pierre, LEO (INRIA Saclay - Ile de France) ; Université Paris-Sud - Paris 11 (UP11) - INRIA - CNRS, Montclair State University ; Montclair State University, Queensland University of Technology [Brisbane] (QUT) ; Queensland University ot Technology, Télécom ParisTech, European Project : 226513, ERC, ERC-2008-AdG, WEBDAM(2008), Suchanek, Fabian, Varde, Aparna, Nayak, Richi, and Senellart, Pierre
Abstract: International audience, The World Wide Web no longer consists just of HTML pages. Our work sheds light on a number of trends on the Internet that go beyond simple Web pages. The hidden Web provides a wealth of data in semi-structured form, accessible through Web forms and Web services. These services, as well as numerous other applications on the Web, commonly use XML, the eXtensible Markup Language. XML has become the lingua franca of the Internet that allows customized markups to be defined for specific domains. On top of XML, the Semantic Web grows as a common structured data source. In this work, we first explain each of these developments in detail. Using real-world examples from scientific domains of great interest today, we then demonstrate how these new developments can assist the managing, harvesting, and organization of data on the Web. On the way, we also illustrate the current research avenues in these domains. We believe that this effort would help bridge multiple database tracks, thereby attracting researchers with a view to extend database technology.

10. Attitude toward a COVID-19 vaccine in France. Different factors according to age (COVID-19 vaccine: The French population’s attitude)

Author: Alleaume, Caroline, Peretti-Watel, Patrick, Verger, Pierre, Launay, Odile, Grp, Coconel, Raude, Jocelyn, Santé publique France - French National Public Health Agency [Saint-Maurice, France], Vecteurs - Infections tropicales et méditerranéennes (VITROME), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA), Observatoire régional de la santé Provence-Alpes-Côte d'Azur [Marseille] (ORS PACA), CIC Cochin Pasteur (CIC 1417), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôtel-Dieu-Groupe hospitalier Broca-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), The COCONEL Group, École des Hautes Études en Santé Publique [EHESP] (EHESP), Centre de recherche en économie et management (CREM), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)-Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Vecteurs - Infections tropicales et méditerranéennes (VITROME), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA)-Groupe d'Etude des Méthodes de l'Analyse Sociologique de la Sorbonne (GEMASS), Fondation Maison des sciences de l'homme (FMSH)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Fondation Maison des sciences de l'homme (FMSH)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)- Southeastern Health Regional Observatory (ORS Paca)-Inserm CIC 1417, Université Paris, Faculté de Médecine Paris Descartes, AP-HP, Hôpital Cochin, and Département des sciences humaines et sociales (SHS)
Subjects: Health (social science), Vaccination, Enquête COCONEL, Covid 19, Refus, Elderly, Attitude, Enquêtes de cohorte, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, France, Population âgée, Geriatrics and Gerontology, COCONEL cohort surveys, Gerontology
Abstract: International audience; Like in many countries, the French health authorities are pinning their hopes on vaccination to stop the spread of the COVID-19 pandemic. However, this requires the public to get the vaccine. Based on six COCONEL surveys carried out during and after the lockdown among the general French adult population, which aimed to explore life conditions during this period and individual perceptions of the situation, this paper aims to investigate the acceptability of a putative vaccine against COVID-19 among the French population, and more specifically to compare attitudes among the elderly, who are more vulnerable to the disease, with those of younger people. Out of the 8,036 respondents, 27.5% declared that they would refuse the vaccine if it were available. Among the age groups of particular interest, 29.2% of people aged 18–64 said they would refuse the vaccine, compared to 12.4% of respondents aged 65 or over. For both groups, this refusal rate fluctuated depending on the date of the survey, gender, household composition, level of household income, and uptake of the last flu vaccine. In conclusion, more attention should be paid to elderly people, as they were more likely to report hostility toward vaccination in general. Finally, considering that several vaccines are now available, further studies should be done to study vaccine uptake in relation to the vaccine offered.; La campagne vaccinale contre la COVID-19 est une priorité sanitaire. Toutefois, l’adhésion de la population française à cette vaccination est un élément clé de sa réussite. À la lumière de six enquêtes COCONEL réalisées en population générale adulte pendant et après le confinement dans l’objectif de documenter les conditions de vie des Français pendant cette période ainsi que leur perception des mesures mises en place par les autorités, cet article propose d’analyser l’intention de se faire vacciner des Français à l’égard d’une vaccination contre la COVID-19, selon l’âge. Plus spécifiquement, l’intention des personnes âgées de 65 ans et plus, particulièrement vulnérables face à cette maladie, comparativement aux personnes plus jeunes. Parmi les 8 036 répondants, 27,5 % refuseraient ce vaccin s’il était disponible ; 29,2 % des 18-64 ans contre 12,4 % des 65 ans et plus. Quel que soit l’âge, ce refus de vaccination varie selon la date d’enquête, mais aussi selon le genre, la composition du foyer, le niveau de revenus, ainsi que la pratique vaccinale antérieure contre la grippe saisonnière. En conclusion, une attention particulière devra être portée aux personnes âgées de 65 ans et plus qui sont plus enclines à manifester une hostilité à la vaccination en général. Enfin, la mise sur le marché de différents vaccins devrait encourager à poursuivre les analyses de l’adhésion vaccinale au regard du vaccin proposé.
Published: 2022

11. The European MAPPYACTS Trial: Precision Medicine Program in Pediatric and Adolescent Patients with Recurrent Malignancies

Author: Pablo Berlanga, Gaelle Pierron, Ludovic Lacroix, Mathieu Chicard, Tiphaine Adam de Beaumais, Antonin Marchais, Anne C. Harttrampf, Yasmine Iddir, Alicia Larive, Aroa Soriano Fernandez, Imene Hezam, Cecile Chevassus, Virginie Bernard, Sophie Cotteret, Jean-Yves Scoazec, Arnaud Gauthier, Samuel Abbou, Nadege Corradini, Nicolas André, Isabelle Aerts, Estelle Thebaud, Michela Casanova, Cormac Owens, Raquel Hladun-Alvaro, Stefan Michiels, Olivier Delattre, Gilles Vassal, Gudrun Schleiermacher, Birgit Geoerger, Institut Català de la Salut, [Berlanga P] Department of Pediatric and Adolescent Oncology, Gustave Roussy Cancer Campus, Université Paris-Saclay, Villejuif, France. [Pierron G] Unité de Génétique Somatique, Service de Génétique, Hospital Group, Institut Curie, Paris, France. [Lacroix L] Department of Pathology and Laboratory Medicine, Translational Research Laboratory and Biobank, AMMICA, INSERM US23/CNRS UMS3655, Gustave Roussy Cancer Campus, Université Paris-Saclay, Villejuif, France. [Chicard M] INSERM U830, Laboratoire de Génétique et Biologie des Cancers, Research Center, PSL Research University, Institut Curie, Paris, France. [Adam de Beaumais T] Clinical Research Direction, Gustave Roussy Cancer Campus, Université Paris-Saclay, Villejuif, France. [Marchais A] INSERM U1015, Gustave Roussy Cancer Campus, Université Paris-Saclay, Villejuif, France. [Soriano Fernandez A] Grup de Recerca Translacional en Càncer en la Infància i l’Adolescència, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Hladun-Alvaro R] Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Servei d’Oncologia i Hematologia Pediàtriques, Vall d’Hebron Hospital Universitari, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus, Institut Gustave Roussy (IGR), Département de cancérologie de l'enfant et de l'adolescent [Gustave Roussy], Institut Curie [Paris], Department of Medical Oncology, Département de médecine oncologique [Gustave Roussy], Unité de génétique et biologie des cancers (U830), Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Plateforme de Bioinformatique [Gustave Roussy], Analyse moléculaire, modélisation et imagerie de la maladie cancéreuse (AMMICa), Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Immunologie anti-tumorale et immunothérapie des cancers (ITIC), Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] (IHU ICAN), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Service de biostatistique et d'épidémiologie (SBE), Direction de la recherche clinique [Gustave Roussy], Institut Gustave Roussy (IGR)-Institut Gustave Roussy (IGR), Centre de Recherche et de Documentation sur l'Océanie (CREDO), École des hautes études en sciences sociales (EHESS)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Biomarqueurs prédictifs et nouvelles stratégies moléculaires en thérapeutique anticancéreuse (U981), Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire d'Excellence en Recherche sur le Médicament et l'Innovation Thérapeutique [Châtenay-Malabry] (LabEx LERMIT), Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM), Département de biologie et pathologie médicales [Gustave Roussy], Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), Prédicteurs moléculaires et nouvelles cibles en oncologie (PMNCO), Centre Léon Bérard [Lyon], Institut d'hématologie et d'oncologie pédiatrique [CHU - HCL] (IHOPe), Biologie Cellulaire et Cancer, Institut Curie [Paris]-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centre hospitalier universitaire de Nantes (CHU Nantes), Istituto di Ricovero e Cura a Carattere Scientifico, Ospedale Casa Sollievo della Sofferenza [San Giovanni Rotondo] (IRCCS), Oncostat (U1018 (Équipe 2)), Institut Gustave Roussy (IGR)-Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Immunologie des tumeurs et immunothérapie (UMR 1015), Vectorologie et thérapeutiques anti-cancéreuses [Villejuif] (UMR 8203), and Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Centre National de la Recherche Scientifique (CNRS)
Subjects: neoplasias::procesos neoplásicos::recurrencia neoplásica local [ENFERMEDADES], Pediatria, Adolescent, [SDV]Life Sciences [q-bio], Carcinoma, High-Throughput Nucleotide Sequencing, Neoplasms [DISEASES], neoplasias [ENFERMEDADES], Càncer - Recaiguda, terapéutica::medicina de precisión [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], Oncology, Mutation, Biomarkers, Tumor, Neoplasms::Neoplastic Processes::Neoplasm Recurrence, Local [DISEASES], Humans, Prospective Studies, Medicina personalitzada, Neoplasm Recurrence, Local, Precision Medicine, Child, Therapeutics::Precision Medicine [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], Cell-Free Nucleic Acids
Abstract: Abstract MAPPYACTS (NCT02613962) is an international prospective precision medicine trial aiming to define tumor molecular profiles in pediatric patients with recurrent/refractory malignancies in order to suggest the most adapted salvage treatment. From February 2016 to July 2020, 787 patients were included in France, Italy, Ireland, and Spain. At least one genetic alteration leading to a targeted treatment suggestion was identified in 436 patients (69%) with successful sequencing; 10% of these alterations were considered “ready for routine use.” Of 356 patients with follow-up beyond 12 months, 107 (30%) received one or more matched targeted therapies—56% of them within early clinical trials—mainly in the AcSé-ESMART platform trial (NCT02813135). Overall, matched treatment resulted in a 17% objective response rate, and of those patients with ready for routine use alterations, it was 38%. In patients with extracerebral tumors, 76% of actionable alterations detected in tumor tissue were also identified in circulating cell-free DNA (cfDNA). Significance: MAPPYACTS underlines the feasibility of molecular profiling at cancer recurrence in children on a multicenter, international level and demonstrates benefit for patients with selected key drivers. The use of cfDNA deserves validation in prospective studies. Our study highlights the need for innovative therapeutic proof-of-concept trials that address the underlying cancer complexity. This article is highlighted in the In This Issue feature, p. 1171
Published: 2022

12. Boundary amenability of $Out(F_N)$

Author: Bestvina , Mladen, Guirardel , Vincent, Horbez , Camille, Department of Mathematics - University of Utah, University of Utah, Institut de Recherche Mathématique de Rennes ( IRMAR ), Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -AGROCAMPUS OUEST-École normale supérieure - Rennes ( ENS Rennes ) -Institut National de Recherche en Informatique et en Automatique ( Inria ) -Institut National des Sciences Appliquées ( INSA ) -Université de Rennes 2 ( UR2 ), Université de Rennes ( UNIV-RENNES ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Mathématiques d'Orsay ( LM-Orsay ), Université Paris-Sud - Paris 11 ( UP11 ) -Centre National de la Recherche Scientifique ( CNRS ), Institut de Recherche Mathématique de Rennes (IRMAR), AGROCAMPUS OUEST, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-École normale supérieure - Rennes (ENS Rennes)-Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA), Laboratoire de Mathématiques d'Orsay (LM-Orsay), Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École normale supérieure - Rennes (ENS Rennes)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-INSTITUT AGRO Agrocampus Ouest, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), and Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS)
Subjects: [ MATH.MATH-GT ] Mathematics [math]/Geometric Topology [math.GT], [ MATH.MATH-GR ] Mathematics [math]/Group Theory [math.GR], General Mathematics, [MATH.MATH-OA]Mathematics [math]/Operator Algebras [math.OA], Mathematics - Operator Algebras, Geometric Topology (math.GT), Group Theory (math.GR), [MATH.MATH-GR]Mathematics [math]/Group Theory [math.GR], Mathematics - Geometric Topology, [MATH.MATH-GT]Mathematics [math]/Geometric Topology [math.GT], FOS: Mathematics, [ MATH.MATH-OA ] Mathematics [math]/Operator Algebras [math.OA], Operator Algebras (math.OA), Mathematics - Group Theory
Abstract: We prove that $Out(F_N)$ is boundary amenable. This also holds more generally for $Out(G)$, where $G$ is either a toral relatively hyperbolic group or a finitely generated right-angled Artin group. As a consequence, all these groups satisfy the Novikov conjecture on higher signatures., Comment: v2: Final version. Accepted in Annales scientifiques de l'\'Ecole normale sup\'erieure
Published: 2022

13. Avis de l'Anses relatif à des nouveaux cas d’intoxications à la vitamine D chez des nourrissonspar mésusage de compléments alimentaires

Author: Danel-Buhl, Nicolas, Boissonnas, Alain, Boltz, Patricia, Crenn, Pascal, Gaboriau, Louise, Jacquesson-Fournols, Laetitia, Jian, Raymond, Kanny, Gisèle, Koppe-Guichard, Laetitia, Morisset, Martine, Plan, Pascal, Renaudin, Jean-Marie, Richard, Ruddy, Rocher, Fanny, Scherer, Philippe, Zazzo, Jean-Fabien, Mondier Casini, Aurélien, Dopter, Aymeric, Huret, Fanny, Nadaud, Perrine, Vo Van Regnault, Gwenn, GHT de l'Artois, Université Paris-Sud - Paris 11 - Faculté de médecine (UP11 UFR Médecine), Université Paris-Sud - Paris 11 (UP11), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), AP-HP. Université Paris Saclay, Centre Régional de PharmacoVigilance Nord-Pas-de-Calais [CHU Lille] (CRPV), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Faculté de Médecine Henri Warembourg - Université de Lille, Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Centre Hospitalier Universitaire de Nancy (CHU Nancy), Hospices Civils de Lyon (HCL), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Centre Hospitalier Emile Durkheim [Epinal] (CH Epinal / CHED), Université Clermont Auvergne (UCA), CHU Nice [Cimiez], Hôpital Cimiez [Nice] (CHU), Retraité, AP-HP - Hôpital Antoine Béclère [Clamart], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Direction de l'Evaluation des Risques (DER), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), and Anses
Subjects: Compléments alimentaires, intoxication, mésusage, Food supplement, vitamine D, Nutrivigilance, vitamin D, misuse, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Abstract: Citation suggérée : Anses. 2023. Avis de l’Anses relatif à « des intoxications à la vitamine D chez des nourrissons par mésusage de compléments alimentaires » (saisine 2022-VIG-0166). Maisons-Alfort: Anses, 13 p; Dans le cadre de son dispositif de nutrivigilance créé en 2009 et depuis la publication de sonavis du 28 juillet 2021 relatif à trois cas de signalements d’effets indésirables sévèresa chezdes nourrissons à la suite du mésusage de compléments alimentaires contenant de lavitamine Db (Anses 2021b), l’Anses a reçu trois nouveaux signalements d’effets indésirablessévères (sévérité de niveau 3, dont deux cas avec menace du pronostic vital) chez desnourrissons susceptibles d’être liés au mésusage de compléments alimentaires achetés surinternet contenant 5 000 UI et 10 000 UI par goutte de vitamine D. Ces trois cas, enregistrésdans la base de données de nutrivigilance sous les numéros 2022-140, 2022-335 et 2022-380ont été jugés d’imputabilité très vraisemblable.En raison de la sévérité des effets indésirables rapportés (hypercalcémies sévères associéesà une néphrocalcinose, anorexie, hypokaliémie, trouble de la repolarisation cardiaque),l’Anses s’est à nouveau autosaisie le 21 septembre 2022, estimant nécessaire de porter cescas de mésusage à la connaissance du public, des metteurs en marché et des professionnelsde santé, dans un but d’amélioration de la sécurité sanitaire du consommateur.
Published: 2023

14. Brief Report: Frailty in Aging People Living With HIV: A Matched Controlled Study

Author: Matteo Vassallo, Louis Bernard, Jacques Reynes, Laure-Anne Gutierrez, Olivia Zaegel-Faucher, Laura Nailler, Claudine Berr, Pascale Leclercq, Claudine Barbuat, Marie Zins, Anna Ozguler, Lionel Lellouche, Alain Makinson, Institut des Neurosciences de Montpellier (INM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Unité Mixte de Recherche d'Épidémiologie des maladies Animales et zoonotiques (UMR EPIA), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Etudes montpelliéraines du monde anglophone (EMMA), Université Paul-Valéry - Montpellier 3 (UPVM), Aix Marseille Université (AMU), CHU Trousseau [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Centre Hospitalier de Cannes, Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Hôpital Raymond Poincaré [AP-HP], Cohortes épidémiologiques en population (CONSTANCES), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université Paris Cité (UPC), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut des Neurosciences de Montpellier - Déficits sensoriels et moteurs (INM), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université de Paris (UP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Université Grenoble Alpes (UGA), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université Paris Cité (UPCité), and Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay
Subjects: Male, Aging, HIV Infections, Comorbidity, Logistic regression, 03 medical and health sciences, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Antiretroviral Therapy, Highly Active, Activities of Daily Living, Prevalence, Humans, Medicine, Pharmacology (medical), 030212 general & internal medicine, Depression (differential diagnoses), Aged, Frailty, Depression, business.industry, Confounding, Odds ratio, Middle Aged, medicine.disease, Confidence interval, CD4 Lymphocyte Count, 3. Good health, Cross-Sectional Studies, Infectious Diseases, Case-Control Studies, Cohort, [SDV.IMM]Life Sciences [q-bio]/Immunology, Female, business, Viral load, 030217 neurology & neurosurgery, Demography
Abstract: International audience; Background: We compared the prevalence of frailty among aging people living with HIV (PLHIV) with people without HIV from the ANS EP58 HAND 55–70 Study.Methods: Cross-sectional multicentric study which consecutively included 200 PLHIV and 1000 people without HIV from the French national CONSTANCES cohort, matched on age, sex, and education level. PLHIV were aged 55–70 years, with a HIV viral load < 50 copies/mL and a lymphocyte T-CD4 level > 200 cells/µL for the last 24 and 12 months, respectively. We measured frailty (>2 items) and prefrailty (one or 2 items) using a proxy of the 5-item Fried score. Multivariate logistic regression was performed to assess the association between HIV and frailty/prefrailty, adjusting for demographic, social, behavioral, and comorbidity confounders.Results: Outcome measures were available for 192 PLHIV and 822 people without HIV. The median age was 62 years, and 84.9% were men. Among PLHIV, the median CD4 cell count was 645.5 cells/µL. Prevalence of frailty/prefrailty was 5.73%/57.3% in PLHIV vs. 1.73%/52.2% in people without HIV, respectively. HIV was associated with prefrailty/frailty [odds ratio = 1.89; 95% confidence interval = 1.37 to 2.61), but after adjusting for social and behavioral factors and comorbidities, HIV was not significantly associated with prefrailty/frailty (odds ratio = 1.24; 95% confidence interval: = 0.84 to 1.81). In PLHIV only, frailty/prefrailty was associated with depressive symptomatology, kidney disease, and time since HIV infection.Conclusions: Prevalence of frailty is increased in aging PLHIV with well-controlled HIV disease, but other factors than HIV are predominant, particularly depression and comorbidities.
Published: 2021

15. Concurrent Nanopore Next-Generation Sequencing of Hepatitis B and Delta Virus Genomes Directly From Patient Plasma

Author: Anne Motte, Céline Boschi, Ludivine Brechard, Jessica Grace Bengone-Abogourin, Philippe Colson, Isabelle Allemand, Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Institut Hospitalier Universitaire Méditerranée Infection (IHU Marseille), Gamétogénèse Apoptose et Génotoxicité - LGAG (Equipe - U967 INSERM), Stabilité génétique, Cellules Souches et Radiations (SCSR (U_967)), Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), ANR-10-IAHU-0003,Méditerranée Infection,I.H.U. Méditerranée Infection(2010), European Project, Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU), Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), COMBE, Isabelle, Instituts Hospitalo-Universitaires - I.H.U. Méditerranée Infection - - Méditerranée Infection2010 - ANR-10-IAHU-0003 - IAHU - VALID, and FEDER PRIMI - INCOMING
Subjects: Delta, Hepatitis B virus, Clinical Biochemistry, Computational biology, Genome, Viral, Biology, Genome, DNA sequencing, Virus, 03 medical and health sciences, Nanopores, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, medicine, Humans, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, Letter to the Editor, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, [SDV.MHEP.ME] Life Sciences [q-bio]/Human health and pathology/Emerging diseases, 0303 health sciences, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, 030306 microbiology, Biochemistry (medical), High-Throughput Nucleotide Sequencing, General Medicine, Hepatitis B, medicine.disease, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, 3. Good health, Nanopore, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, [SDV.MP.BAC] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, Diagnostic Genetics, [SDV.MP.PAR] Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology
Abstract: International audience
Published: 2021

16. On the Complexity of Consistent Query Answering in the Presence of Simple Ontologies

Author: Meghyn Bienvenu, IASI, Laboratoire de Recherche en Informatique (LRI), and Université Paris-Sud - Paris 11 (UP11)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)
Subjects: General Medicine, ComputingMilieux_MISCELLANEOUS, [INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI]
Abstract: Consistent query answering is a standard approach for producing meaningful query answers when data is inconsistent. Recent work on consistent query answering in the presence of ontologies has shown this problem to be intractable in data complexity even for ontologies expressed in lightweight description logics. In order to better understand the source of this intractability, we investigate the complexity of consistent query answering for simple ontologies consisting only of class subsumption and class disjointness axioms. We show that for conjunctive queries with at most one quantified variable, the problem is first-order expressible; for queries with at most two quantified variables, the problem has polynomial data complexity but may not be first-order expressible; and for three quantified variables, the problem may become co-NP-hard in data complexity. For queries having at most two quantified variables, we further identify a necessary and sufficient condition for first-order expressibility. In order to be able to handle arbitrary conjunctive queries, we propose a novel inconsistency-tolerant semantics and show that under this semantics, first-order expressibility is always guaranteed. We conclude by extending our positive results to DL-Lite ontologies without inverse.
Published: 2021

17. Erratum: Searches for continuous gravitational waves from 15 supernova remnants and fomalhaut b with advanced LIGO (2019, ApJ, 875, 122)*

Author: A. Parida, S. S. Eikenberry, F. Frasconi, Chris A. Collins, R. Flaminio, Marcus E. Lower, Rosa Poggiani, V. Frey, E. K. Wessel, Nikhil Sarin, Odylio D. Aguiar, I. W. Martin, S. Farinon, P. Raffai, Andrew Matas, C. F. Da Silva Costa, M. A. Okada, G. Rutins, Graham Woan, Sebastiano Bernuzzi, D. Passuello, A. Cirone, H. S. Chen, Hyun Lee, J. D. Lough, K. Mason, S. A. Bilgili, E. C. Ferreira, Robert L. Byer, J. Calderón Bustillo, Sanjeev Dhurandhar, O. Halim, N. A. Robertson, Stuart Reid, F. J. Hayes, Patrick Godwin, N. Sennett, P. Kumar, Jacob Scheuer, B. R. Hall, J. Hanks, R. M. Martin, David A. Nichols, Edward K. Porter, J. G. Bartlett, Márton Tápai, K. W. Tsang, C. Horst, W. A. Campbell, Andreas Freise, C. V. Kalaghatgi, M. Rakhmanov, G. Pagano, Paul D. Lasky, J. W. Westhouse, M. C. Araya, Srishti Tiwari, C. Lazzaro, Patricia Schmidt, V. Brisson, Bernard F. Schutz, Li Ju, Matthew Pitkin, D. Cohen, Kiran Prasai, P. J. Veitch, S. A. Usman, C. Messenger, Liam Cunningham, E. A. M. Muniz, Daniel A. Shaddock, P. Gruning, Brittany Kamai, Riccardo Ciolfi, Alberto Vecchio, Geoffrey Mo, J. M. Fishner, Roman Schnabel, J. Hanson, M. Wade, M. Montani, P. Sharma, Héctor Estellés, N. Letendre, F. Ricci, A. Lenon, J. E. Brau, A. A. van Veggel, Richard Gray, Efim A. Khazanov, Peter T. H. Pang, C. Affeldt, G. Ballardin, Moritz Mehmet, A. A. Ciobanu, M. Granata, Minchuan Zhou, F. Marion, P. Brockill, Nancy Aggarwal, Hang Yu, P. G. Murray, Fabien Kéfélian, J. H. Hough, P. W. F. Forsyth, S. R. Thondapu, J. R. Palamos, Michele Zanolin, S. Mukherjee, T. J. Massinger, T. Vo, V. Kalogera, N. Leroy, G. D. Hammond, Javed Rana, H. Fong, G. Greco, M. Haney, T. A. Callister, Alec Mishkin, R. Cavalieri, S. R. P. Mohapatra, G. Giordano, K. Toland, A. K. Srivastava, A. E. Pace, H. Ohta, Vuk Mandic, B. Bécsy, M. Kasprzack, I. Dave, B. D. Lackey, R. L. Ward, Scott Coughlin, A.J. Weinstein, K. H. Lai, M. Phelps, H. S. Cho, L. Kuo, H. Yamamoto, E. Capocasa, M. Chan, S. Walsh, D. J. McManus, A. Schönbeck, B. Rajbhandari, Andrew Mehta, S. D. Linker, R. Robie, M. Fletcher, B. Hughey, R. D. Kennedy, José A. Font, Gregorio Carullo, S. Kumar, J. Prasad, H. K. Gulati, V. Raymond, Steven Bloemen, H. J. Bulten, Shiuh Chao, P. J. Sutton, N. Singh, C. Buy, Samuele Cortese, J. McIver, Vivishek Sudhir, P. A. Altin, A. Basti, N. A. Lockerbie, E. Schreiber, Charalampos Markakis, P. Grassia, Kipp Cannon, M. Steinke, P.H. Nguyen, Ryan N. Lang, Z. Doctor, Alyssa Garcia, J. H. Romie, Carlos O. Lousto, S. Sitmukhambetov, Alejandro Torres-Forné, A. Samajdar, D. M. Wysocki, T. Mistry, Mark A. Scheel, Charlie Hoy, F. Clara, M. A. Aloy, T. M. Evans, C. North, Thomas Dent, P. Corban, P. Ajith, B. Mours, Mandar Patil, Abhirup Ghosh, J. Neilson, Bala R. Iyer, Y. K. Lecoeuche, M. Muratore, Karsten Danzmann, Fabrizio Barone, N. Mukund, P. B. Covas, M. C. Edwards, T. Hinderer, Marta Colleoni, J. A. Giaime, Michael Pürrer, R. Pedurand, Benno Willke, A. Grado, D. C. Vander-Hyde, S. S. Y. Chua, J. 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McGuire, J. F. Read, F. Nocera, C. Zhao, Alicia M. Sintes, S. Di Pace, K. Haris, T. Zhang, N. Demos, Thibaut Jacqmin, T. Regimbau, I. Maksimovic, G. Hemming, S. M. Koehlenbeck, M. Saleem, M. Oliver, Douglas Davis, Geraint Pratten, E. Goetz, Tarun Souradeep, Andrea Taracchini, D. Bersanetti, G. Ashton, S. Penn, J. V. van Heijningen, Yu Wang, F. Thies, G. L. Mansell, V. Dattilo, Edwin J. Son, Eric Thrane, Stefan Hild, Y. Ma, A. Brillet, C. Michel, M. Vardaro, Sarah Caudill, T. D. Knowles, F. Robinet, V. B. Adya, J. K. Wofford, F. Cleva, M. P. Ross, T. B. Edo, M. Pichot, Maximiliano Isi, E. M. Gretarsson, Ying Guo, D. Beniwal, Peter Fritschel, Wenxiao Wang, M. Masso-Reid, S. Kwang, L. E. Sanchez, Enrico Calloni, G. Traylor, Thomas Corbitt, L. Salconi, C. A. Costa, Zhihui Du, Laboratoire des matériaux avancés (LMA), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), (Astro)-Particles Physics, Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)
Subjects: Physics, [PHYS]Physics [physics], 010504 meteorology & atmospheric sciences, Gravitational wave, Astronomy, Astronomy and Astrophysics, 01 natural sciences, LIGO, Supernova, Fomalhaut, Space and Planetary Science, 0103 physical sciences, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], 010303 astronomy & astrophysics, ComputingMilieux_MISCELLANEOUS, 0105 earth and related environmental sciences
Abstract: Equation (5) of the published article?(Abbott et al. 2019) is in error; it should read (Formula Presented) The upper limits on ò presented in the published article are unaffected by this error.
Published: 2021

18. In vivo inactivation of RAD51-mediated homologous recombination leads to premature aging, but not to tumorigenesis

Author: Gabriel Matos-Rodrigues, Vilma Barroca, Ali-Akbar Muhammad, Awatef Allouch, Stephane Koundrioukoff, Daniel Lewandowski, Emmanuelle Despras, Josée Guirouilh-Barbat, Lucien Frappart, Patricia Kannouche, Pauline Dupaigne, Eric Le Cam, Jean-Luc Perfettini, Paul-Henri Romeo, Michelle Debatisse, Maria Jasin, Gabriel Livera, Emmanuelle Martini, Bernard S. Lopez, Institut Cochin (IC UM3 (UMR 8104 / U1016)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire de Développement des Gonades, Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Institut de Radiobiologie Cellulaire et Moléculaire (IRCM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Signalisation, noyaux et innovations en cancérologie (UMR8126), Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Centre National de la Recherche Scientifique (CNRS), Radiothérapie Moléculaire et Innovation Thérapeutique (RaMo-IT), Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Stabilité Génétique et Oncogenèse (UMR 8200), Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Leibniz Association, Radiothérapie moléculaire (UMR 1030), Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Memorial Sloan Kettering Cancer Center (MSKCC), Stabilité génétique, cellules souches et radiations (SGCSR (U_1274 / UMR_E_008)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université Paris Cité (UPCité), Intégrité du génome et cancers (IGC), École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut Gustave Roussy (IGR)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut Gustave Roussy (IGR), and Memorial Sloane Kettering Cancer Center [New York]
Subjects: Genetics Homologous recombination, tumorigenesis, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, mouse model, [SDV]Life Sciences [q-bio], aging, RAD51, [SDV.CAN]Life Sciences [q-bio]/Cancer, Biological Sciences
Abstract: Genetic instability is a hallmark of both cancer and aging. Homologous recombination (HR) is a prominent DNA repair pathway maintaining genomic integrity. Mutations in many HR genes lead to cancer predisposition. Paradoxically, the consequences of mutations in the pivotal HR player, RAD51, on cancer development remain puzzling. Moreover, in contrast with other HR genes, RAD51 mouse models are not available to experimentally address the role of RAD51 on aging and carcinogenesis, in vivo. Here, we engineered a mouse model with an inducible dominant negative form of RAD51 (SMRad51) that suppresses RAD51-mediated HR without stimulating alternative non-conservative repair pathways. We found that, in vivo expression of SMRad51 did not trigger tumorigenesis, but instead induced premature aging. We propose that these in vivo phenotypes result from the exhaustion of proliferating progenitors submitted to chronic endogenous replication stress resulting from RAD51-mediated HR suppression. Our data underline the importance of the RAD51 activity for progenitors homeostasis, preventing aging, and more generally for the balance between cancer and aging.
Published: 2022

19. The association of ARRB1 polymorphisms with response to antidepressant treatment in depressed patients

Author: Kenneth Chappell, Abd El Kader Ait Tayeb, Romain Colle, Jérôme Bouligand, Khalil El-Asmar, Florence Gressier, Séverine Trabado, Denis Joseph David, Bruno Feve, Laurent Becquemont, Emmanuelle Corruble, Céline Verstuyft, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Service de psychiatrie [Le Kremlin-Bicêtre], Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bicêtre, Signalisation Hormonale, Physiopathologie Endocrinienne et Métabolique, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Hôpital Bicêtre, American University of Beirut [Beyrouth] (AUB), Centre de Recherche Saint-Antoine (CRSA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Lipodystrophies, adaptations métaboliques et hormonales, et vieillissement [CRSA], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] (IHU ICAN), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), and Feve, Bruno
Subjects: [SDV] Life Sciences [q-bio], Pharmacology, major depressive disorder, [SDV]Life Sciences [q-bio], high-throughput sequencing, Pharmacology (medical), β Arrestin, ARRB1, pharmacogenetics
Abstract: Introduction: β-arrestin 1, a protein encoded by ARRB1 involved in receptor signaling, is a potential biomarker for the response to antidepressant drug (ATD) treatment in depression. We examined ARRB1 genetic variants for their association with response following ATD treatment in METADAP, a cohort of 6-month ATD-treated depressed patients.Methods: Patients (n = 388) were assessed at baseline (M0) and after 1 (M1), 3 (M3), and 6 months (M6) of treatment for Hamilton Depression Rating Scale (HDRS) changes, response, and remission. Whole-gene ARRB1 variants identified from high-throughput sequencing were separated by a minor allele frequency (MAF)≥5%. Frequent variants (i.e., MAF≥5%) annotated by RegulomeDB as likely affecting transcription factor binding were analyzed using mixed-effects models. Rare variants (i.e., MAFResults: The variant set analysis of rare variants was significant in explaining HDRS score changes (T = 878.9; p = 0.0033) and remission (T = -1974.1; p = 0.034). Rare variant counts were significant in explaining response (p = 0.016), remission (p = 0.022), and HDRS scores at M1 (p = 0.0021) and M3 (p=p = 0.0055 | rs536852: p = 0.046) and remission (rs553664: p = 0.026 | rs536852: p = 0.012) through their interactions with time. At M6, significantly higher HDRS scores were observed in rs553664 AA homozygotes (13.98 ± 1.06) compared to AG heterozygotes (10.59 ± 0.86; p = 0.014) and in rs536852 GG homozygotes (14.88 ± 1.10) compared to AG heterozygotes (11.26 ± 0.95; p = 0.0061). Significantly lower remitter rates were observed in rs536852 GG homozygotes (8%, n = 56) compared to AG heterozygotes (42%, n = 105) at M6 (p = 0.0018).Conclusion: Our results suggest ARRB1 variants may influence the response to ATD treatment in depressed patients. Further analysis of functional ARRB1 variants and rare variant burden in other populations would help corroborate our exploratory analysis. β-arrestin 1 and genetic variants of ARRB1 may be useful clinical biomarkers for clinical improvement following ATD treatment in depressed individuals.Clinical Trial Registration:clinicaltrials.gov; identifier NCT00526383
Published: 2022

20. QSM4SENIOR: Quantitative susceptibility mapping in the aging of the healthy brain

Author: Guevara, Miguel, Cam, Davy, Badagbon, Jacques, Bottlaender, Michel, Cointepas, Yann, Mangin, Jean-François, Rochefort, Ludovic De, Vignaud, Alexandre, Building large instruments for neuroimaging: from population imaging to ultra-high magnetic fields (BAOBAB), Service NEUROSPIN (NEUROSPIN), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), Ventio, Institut d'Imagerie BioMédicale (I2BM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut d'imagerie neurofonctionnelle (IIN), Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-École des hautes études en sciences sociales (EHESS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Ecole Nationale Supérieure des Télécommunications (ENST)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut des Sciences du Vivant Frédéric JOLIOT (JOLIOT), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), European Project: 824087 ,EOSC-Life, Service Hospitalier Frédéric Joliot (SHFJ), IFR de Neuroimagerie Fonctionnelle (IFR 49), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Neuroimagerie cognitive (LCogn), Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Épilepsie de l'enfant et plasticité cérébrale (Inserm U663), and Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: SENIOR, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, [SDV]Life Sciences [q-bio], R2, QSM, cloud computing, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], iron load, Cloud, MRI
Abstract: This work presents preliminary results for the QSM4SENIOR project, a partnership between NeuroSpin (CEA) and Ventio. A poster was presented at QMR Lucca, Italy 2022, a joint workshop on MR phase, magnetic susceptibility and electrical properties mapping. It introduces a pipeline for computing the Quantitative Susceptibility Mapping (QSM) from the data of healthy senior participants (SENIOR database). The pipeline allows the computation of clean and exploitable QSM, thanks to a phase pre-processing to reduce the presence of artifacts in the 7T MRI data. These maps will be then used for studying the iron accumulation in the normal aging process. This computation was performed in a secured cloud environment, provided by de.NBI Cloud.
Published: 2022
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21. Comparing fractional quantum Hall Laughlin and Jain topological orders with the anyon collider

Author: M. Ruelle, E. Frigerio, J.-M. Berroir, B. Plaçais, J. Rech, A. Cavanna, U. Gennser, Y. Jin, G. Fève, Physique Mésoscopique, Laboratoire de physique de l'ENS - ENS Paris (LPENS), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Département de Physique de l'ENS-PSL, École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Département de Physique de l'ENS-PSL, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Centre de Physique Théorique - UMR 7332 (CPT), Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Centre de Nanosciences et de Nanotechnologies [Orsay] (C2N), Université Paris-Sud - Paris 11 (UP11)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), RENATECH network, ANR-21-CE30-0064,ANY-HALL,Statistiques d'Anyons dans les conducteurs de Hall quantique(2021), Gulliver (UMR 7083), Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), CPT - E6 Nanophysique, Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de photonique et de nanostructures (LPN), Centre National de la Recherche Scientifique (CNRS), Centre de Nanosciences et Nanotechnologies (C2N (UMR_9001)), and Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Strongly correlated materials, Condensed Matter - Strongly Correlated Electrons, Strongly Correlated Electrons (cond-mat.str-el), Condensed Matter - Mesoscale and Nanoscale Physics, Mesoscale and Nanoscale Physics (cond-mat.mes-hall), General Physics and Astronomy, FOS: Physical sciences, [PHYS.COND.CM-SCE]Physics [physics]/Condensed Matter [cond-mat]/Strongly Correlated Electrons [cond-mat.str-el], Condensed matter physics, Mesoscopics, [PHYS.COND.CM-MSQHE]Physics [physics]/Condensed Matter [cond-mat]/Mesoscopic Systems and Quantum Hall Effect [cond-mat.mes-hall]
Abstract: Anyon collision experiments have recently demonstrated the ability to discriminate between fermionic and anyonic statistics. However, only one type of anyons associated with the simple Laughlin state at filling factor $\nu=1/3$ has been probed so far. It is now important to establish anyon collisions as quantitative probes of fractional statistics for more complex topological orders, with the ability to distinguish between different species of anyons with different statistics. In this work, we use the anyon collider to compare the Laughlin $\nu=1/3$ state, which is used as the reference state, with the more complex Jain state at $\nu=2/5$, where low energy excitations are carried by two co-propagating edge channels. We demonstrate that anyons generated on the outer channel of the $\nu=2/5$ state (with a fractional charge $e^*=e/3$) have a similar behavior compared to $\nu=1/3$, showing the robustness of anyon collision signals for anyons of the same type. In contrast, anyons emitted on the inner channel of $\nu=2/5$ (with a fractional charge $e^*=e/5$) exhibit a reduced degree of bunching compared to the $\nu=1/3$ case, demonstrating the ability of the anyon collider to discriminate not only between anyons and fermions, but also between different species of anyons associated with different topological orders of the bulk. Our experimental results for the inner channel of $\nu=2/5$ also point towards an influence of interchannel interactions in anyon collision experiments when several co-propagating edge channels are present. A quantitative understanding of these effects will be important for extensions of anyon collisions to non-abelian topological orders, where several charged and neutral modes propagate at the edge., Comment: 17 pages, 5 figures
Published: 2022

22. Differential impact of parental region of birth on negative parenting behavior and its effects on child mental health: Results from a large sample of 6 to 11 year old school children in France

Author: Mathilde M. Husky, Morton Beiser, Taraneh Shojaei, Christophe Fermanian, Isabelle Pitrou, Arjumand Siddiqi, Christine Chan Chee, Viviane Kovess-Masfety, École des Hautes Études en Santé Publique [EHESP] (EHESP), Modèles et méthodes de l'évaluation thérapeutique des maladies chroniques (U738 / UMR_S738), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Diderot - Paris 7 (UPD7), Unité de recherche clinique, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Ambroise Paré [AP-HP], Epidémiologie, Démographie et Sciences Sociales: santé reproductive, sexualité et infection à VIH (Inserm U569), Epidémiologie, sciences sociales, santé publique (IFR 69), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d'études démographiques (INED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Fondation pour la santé publique, Université Paris Descartes - Paris 5 (UPD5)-MGEN, Modèles et méthodes de l'évaluation thérapeutique des maladies chroniques, Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Ambroise Paré, and Université Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut national d'études démographiques (INED)
Subjects: Adult, Male, Parents, Child psychopathology, media_common.quotation_subject, Immigration, 6 to 11 year old school children, Psychological intervention, Child Behavior, Internalizing disorders, Parenting styles, Parenting behavior, 050109 social psychology, Context (language use), Child Behavior Disorders, Developmental psychology, Ethno-cultural background, Child Development, Residence Characteristics, Risk Factors, Surveys and Questionnaires, Ethnicity, Prevalence, Humans, Externalizing disorders, 0501 psychology and cognitive sciences, Child, 10. No inequality, Association (psychology), Children, media_common, Parenting, 4. Education, 05 social sciences, Strengths and Difficulties Questionnaire, Mental health, Psychiatry and Mental health, Cross-Sectional Studies, Child mental health, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, France, Psychology, Research Article, 050104 developmental & child psychology
Abstract: International audience; BackgroundIn France, one in 10 residents has immigrated mainly from North Africa, West Africa or the Caribbean including the French West Indies. However little is known about how parents from these regions behave when they migrate to countries that have different cultural norms. It is therefore important to determine how ethno-cultural background affects parental behavior and subsequent child mental health in the context of immigration. The objectives are: 1) to compare negative parenting behaviors of French residents from diverse ethno-cultural backgrounds 2) to examine the relationship between parental region of origin and child mental health, and 3) to investigate the extent to which ethno-cultural context moderates the effect of parenting styles on child mental health.MethodsA cross-sectional study was conducted in 2005 in 100 schools in South-East France. The Dominic Interactive and the parent-reported Strengths and Difficulties Questionnaire were used to assess child psychopathology. The Parent Behavior and Attitude Questionnaire was used to assess parenting styles. The final sample included data on 1,106 mother and child dyads.ResultsCaring and punitive attitudes were significantly different across mothers as a function of region of origin. This association was stronger for punitive attitudes with the highest prevalence in the Caribbean/African group, while mothers from Maghreb were more similar to French natives. Differences in caring behaviors were similar though less pronounced. Among children of Maghrebian descent, punitive parenting was associated with an increased risk of internalizing disorders while this association was weaker among children of African and Afro-Caribbean descent.ConclusionsParental region of origin is an important component of both parenting styles and their effect on child mental health. Interventions on parenting should consider both the region of origin and the differential impact of origin on the effect of parenting styles, thus allowing for a finer-grained focus on high-risk groups.
Published: 2022

23. Development of radioactive beams at ALTO: Part 1. Physicochemical comparison of different types of UCx targets using a multivariate statistical approach

Author: Julien Guillot, B. Roussière, Sylvain Denis, Sandrine Tusseau-Nenez, François Brisset, Nicole Barré-Boscher, Institut de Physique Nucléaire d'Orsay (IPNO), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de physique de la matière condensée (LPMC), École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie Moléculaire et des Matériaux d'Orsay (ICMMO), Université Paris-Sud - Paris 11 (UP11)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie et des Matériaux Paris-Est (ICMPE), and Institut de Chimie du CNRS (INC)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Nuclear and High Energy Physics, Materials science, Physics - Instrumentation and Detectors, FOS: Physical sciences, chemistry.chemical_element, Sintering, 02 engineering and technology, Carbon nanotube, 01 natural sciences, law.invention, chemistry.chemical_compound, law, 0103 physical sciences, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], [PHYS.COND]Physics [physics]/Condensed Matter [cond-mat], Porosity, Instrumentation, 010302 applied physics, Fission products, Condensed Matter - Materials Science, Aggregate (composite), Materials Science (cond-mat.mtrl-sci), Instrumentation and Detectors (physics.ins-det), 021001 nanoscience & nanotechnology, Microstructure, chemistry, Uranium carbide, 0210 nano-technology, Biological system, Carbon
Abstract: International audience; The optimization of the microstructure of the UCx target is a key point since many years in the field of ISOL method. The ultimate goal is to facilitate the release of the fission products, especially those with short half-lives. Fourteen UCx samples were synthetized from different uranium and carbon sources using three mixing protocols. All carburized samples were systematically characterized in terms of nature and proportion phases, grain and aggregate size, open and close porosity proportion and open pore size distribution. Our results were analysed using a multivariate statistical approach in order to remove any subjective bias. Strong correlations between the physicochemical characteristics of the samples as well as the impact of the synthesis process have been highlighted. In particular, using carbon nanotubes as carbon source combined with a new method of mixing is the key parameter to limit the sintering and to obtain samples with small grains and a high porosity well distributed over small pores. Moreover the microstructure obtained proved to be stable at high temperature.
Published: 2022

24. Photodetachment of Deprotonated R‐Mandelic Acid: The Role of Proton Delocalization on the Radical Stability

Author: Franco L. Molina, Rafael A. Jara‐Toro, Jennifer A. Noble, Claude Dedonder‐Lardeux, Christophe Jouvet, Gustavo A. Pino, Instituto de Investigaciones en Físico Química [Córdoba] (INFIQC), Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] (CONICET)-Facultad de Ciencias Químicas [Córdoba], Universidad Nacional de Córdoba [Argentina]-Universidad Nacional de Córdoba [Argentina], Physique des interactions ioniques et moléculaires (PIIM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Centre Laser de l'Université Paris Sud (CLUPS), Université Paris-Sud - Paris 11 (UP11), Laboratoire de Photophysique Moléculaire (PPM), and Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Anions, Isomerism, Mandelic Acids, [PHYS.PHYS.PHYS-CHEM-PH]Physics [physics]/Physics [physics]/Chemical Physics [physics.chem-ph], Protons, Physical and Theoretical Chemistry, Atomic and Molecular Physics, and Optics, Hydrogen
Abstract: The photodetachment and stability of R-Mandelate, the deprotonated form of the R-Mandelic acid, was investigated by observing the neutral species issued from either simple photodetachment or dissociative photodetachment in a cold anions set-up. R-Mandalate has the possibility to form an intramolecular ionic hydrogen-bond between adjacent hydroxyl and carboxylate groups. The potential energy surface along the proton transfer (PT) coordinate between both groups (O
Published: 2022

25. Genotype-phenotype description of Vitamin-D Dependent Rickets 1A: CYP27B1 p.(Ala129Thr) variant induces a milder disease

Author: Marie-Noëlle Méaux, Jérôme Harambat, Anya Rothenbuhler, Juliane Léger, Peter Kamenicky, Sylvie Soskin, Olivia Boyer, Emese Boros, Pascal D’Anella, Brigitte Mignot, Maite Gebhart, Philippe Vic, Nicolas Richard, Béatrice Thivichon-Prince, Bruno Francou, Agnès Linglart, Justine Bacchetta, Arnaud Molin, INSERM1033, CHU Bordeaux [Bordeaux], Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Pellegrin, CHU Bordeaux [Bordeaux]-Groupe hospitalier Pellegrin, Service d'endocrinologie pédiatrique [CHU Bicêtre], Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de Référence des Maladies Endocriniennes Rares de la Croissance [APHP Robert Debré], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Robert Debré-Université Paris Cité (UPCité), AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Les Hôptaux universitaires de Strasbourg (HUS), CHU Strasbourg, CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Service de Génétique [CHU Caen], Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Biologie, génétique et thérapies ostéoarticulaires et respiratoires (BIOTARGEN), Normandie Université (NU)-Normandie Université (NU), Institut de Génomique Fonctionnelle de Lyon (IGFL), École normale supérieure - Lyon (ENS Lyon)-Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Signalisation Hormonale, Physiopathologie Endocrinienne et Métabolique, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Physiologie et physiopathologie endocriniennes (PHYSENDO), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, HUE, Erika, and École normale supérieure de Lyon (ENS de Lyon)-Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL)
Subjects: [SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health, Endocrinology, VDDR1A, CYP27B1, Endocrinology, Diabetes and Metabolism, Biochemistry (medical), Clinical Biochemistry, [SDV.BA.MVSA] Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health, Genotype-phenotype, Biochemistry, 1-alpha hydroxylase, Rickets
Abstract: IntroductionVitamin D–dependent rickets type 1A (VDDR1A) is a rare genetic disease associated with loss-of-function variations in the gene encoding the vitamin D–activating enzyme 1α-hydroxylase (CYP27B1). Phenotype-genotype correlation is unclear. Long-term outcome data are lacking. The objective of this study was to describe characteristics and outcomes to search for a phenotype-genotype correlation.MethodsWe retrospectively collected clinical data, genetic features, and outcomes from 24 genetically confirmed cases from 10 French centers; results are presented as median (min–max).ResultsClinical symptoms at diagnosis (age, 1.5 [0.5-8.7] years) were mainly bone and neurological abnormalities, and laboratory data showed hypocalcemia (1.97 [1.40-2.40] mmol/L), hypophosphatemia (−3.4 [−13.4 to (−)0.2] SD score for age), low 25OHD and low 1,25(OH)2D3, secondary hyperparathyroidism with PTH at 6.6 (1.3-13.7) times the upper limit for normal (ULN; PTH expressed as ULN to homogenize data presentation), and increased alkaline phosphatase (1968 [521-7000] IU/L). Bone radiographs were abnormal in 83% of patients. We identified 17 variations (11 missense, 3 frameshift, 2 truncating, and 1 acceptor splice site variations) in 19 families (homozygous state in 58% [11/19]). The partial loss-of-function variation p.(Ala129Thr) was associated with a milder phenotype: older age at diagnosis, higher serum calcium (2.26 vs 1.85 mmol/L), lower PTH (4.7 vs 7.5 ULN), and lower alkaline phosphatase (759 vs 2082 IU/L). Patients were treated with alfacalcidol. Clinical (skeletal, neurological), biochemical, and radiological outcomes were satisfactory, and complications occurred if there was bad adherence.ConclusionOverall, our findings highlight good outcomes under substitutive treatment and the need of a closer follow-up of eyes, teeth, kidneys, and blood pressure in VDDR1A.
Published: 2022

26. Snowmass 2021 Letter of Interest: Decays of Heavy Flavors Beauty, Charm, and Tau

Author: Amhis, Y., Banerjee, Sw, Ben-Haim, E., Bona, M., Bozek, A., Bozzi, C., Brodzicka, J., Chrzaszcz, M., Dingfelder, J., Egede, U., Gersabeck, M., Gershon, T., Goldenzweig, P., Hayasaka, K., Hayashii, H., Johnson, D., Kenzie, M., Kuhr, T., Leroy, O., Li, H. B., Lusiani, A., Miyabayashi, K., Naik, P., Nanut, T., Patel, M., Pompili, A., Rama, M., Michael Roney, Rotondo, M., Schneider, O., Schwanda, C., Schwartz, A. J., Shwartz, B., Serrano, J., Soffer, A., Tonelli, D., Urquijo, P., Kooten, R., Yelton, J., Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), HEP, INSPIRE, Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)
Subjects: [PHYS.HEXP] Physics [physics]/High Energy Physics - Experiment [hep-ex], hep-ex, new physics, High Energy Physics::Phenomenology, lepton: flavor: violation, FOS: Physical sciences, hep-ph, High Energy Physics - Experiment, [PHYS.HPHE] Physics [physics]/High Energy Physics - Phenomenology [hep-ph], heavy quark: decay, High Energy Physics - Phenomenology, High Energy Physics - Experiment (hep-ex), High Energy Physics - Phenomenology (hep-ph), [PHYS.HPHE]Physics [physics]/High Energy Physics - Phenomenology [hep-ph], charm: decay, bottom: decay, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], tau: decay, baryon number: violation, lepton number: violation, Particle Physics - Experiment, Particle Physics - Phenomenology
Abstract: The Heavy Flavor Averaging Group provides this Letter of Interest (LOI) as input to the Snowmass 2021 Particle Physics Community Planning Exercise organized by the Division of Particles and Fields of the American Physical Society. Research in heavy flavor physics is an essential component of particle physics, both within and beyond the Standard Model. To fully realize the potential of this field, we advocate strong support within the U.S. high energy physics program for ongoing and future experimental and theory research in heavy flavor physics., Comment: 5 pages, Letter of Interest for Snowmass 2021
Published: 2022

27. Longitudinal evaluation of the impact of immunosuppressive regimen on immune responses to COVID-19 vaccination in kidney transplant recipients

Author: Wiedemann, Aurélie, Pellaton, Céline, Dekeyser, Manon, Guillaumat, Lydia, Déchenaud, Marie, Krief, Corinne, Lacabaratz, Christine, Grimbert, Philippe, Pantaleo, Giuseppe, Lévy, Yves, Durrbach, Antoine, Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), IMRB - 'From pathophysiology towards immune-basedinterventions in HIV infection' [Créteil] (U955 Inserm - UPEC), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Vaccine Research Institute [Créteil, France] (VRI), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Université de Lausanne = University of Lausanne (UNIL), Institut Gustave Roussy (IGR), Immunologie intégrative des tumeurs et immunothérapie des cancers (INTIM), Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Henri Mondor, Service de néphrologie et transplantation, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Lausanne University Hospital, AP-HP, Hôpital Henri-Mondor Albert-Chenevier, Service d'Immunologie Clinique et Maladies Infectieuses 94000 Créteil, France, Department of Nephrology [Le Kremlin-Bicêtre], Institut francilien de recherche en néphrologie et transplantation [Le Kremlin-Bicêtre] (IFRNT), Université Paris-Sud - Paris 11 (UP11)-AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre)-Université Paris-Sud - Paris 11 (UP11)-AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), and European Project: CoVICIS
Subjects: immunosuppressive regimen, immunocompromised, mRNA vaccine, [SDV]Life Sciences [q-bio], COVID-19, General Medicine, immune responses
Abstract: International audience; Immunocompromised patients have a high risk of death from SARS-CoV-2 infection. Vaccination with an mRNA vaccine may protect these patients against severe COVID-19. Several studies have evaluated the impact of immune-suppressive drug regimens on cellular and humoral responses to SARS-CoV-2 variants of concern in this context. We performed a prospective longitudinal study assessing specific humoral (binding and neutralizing antibodies against spike (S) and T-lymphocyte (cytokine secretion and polyfunctionality) immune responses to anti-COVID-19 vaccination with at least two doses of BNT162b2 mRNA vaccine in stable kidney transplant recipients (KTR) on calcineurin inhibitor (CNI)- or belatacept-based treatment regimens. Fifty-two KTR−31 receiving CNI and 21 receiving belatacept—were enrolled in this study. After two doses of vaccine, 46.9% of patients developed anti-S IgG. Anti-spike IgG antibodies were produced in only 21.4% of the patients in the belatacept group, vs. 83.3% of those in the CNI group. The Beta and Delta variants and, more importantly, the Omicron variant, were less well neutralized than the Wuhan strain. T-cell functions were also much weaker in the belatacept group than in the CNI group. Renal transplant patients have an impaired humoral response to BNT162b2 vaccination. Belatacept-based regimens severely weaken both humoral and cellular vaccine responses. Clinically, careful evaluations of at least binding IgG responses, and prophylactic or post-exposure strategies are strongly recommended for transplant recipients on belatacept-based regimens.
Published: 2022

28. Combinaison cohérente d’amplificateurs à semiconducteur pour Lidar DIAL H20 aéroporté

Author: Liu, Qin, Janicot, Sylvie, Totems, Julien, Georges, Patrick, Lucas-Leclin, Gaëlle, Laboratoire Charles Fabry / Lasers, Laboratoire Charles Fabry (LCF), Institut d'Optique Graduate School (IOGS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut d'Optique Graduate School (IOGS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] (LSCE), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Chimie Atmosphérique Expérimentale (CAE), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Laboratoire Charles Fabry de l'Institut d'Optique / Elsa, Laboratoire Charles Fabry de l'Institut d'Optique (LCFIO), Université Paris-Sud - Paris 11 (UP11)-Institut d'Optique Graduate School (IOGS)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11)-Institut d'Optique Graduate School (IOGS)-Centre National de la Recherche Scientifique (CNRS), Institut d'Optique Graduate School (IOGS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), and SFO - Société Française d'Optique
Subjects: [PHYS.PHYS.PHYS-OPTICS]Physics [physics]/Physics [physics]/Optics [physics.optics], [SPI.OPTI]Engineering Sciences [physics]/Optics / Photonic
Abstract: Session LIDAR; International audience
Published: 2022

29. Échange de savoirs entre le patient et le pharmacien : une étude à méthodes mixtes pour explorer le rôle des pharmaciens dans l'éducation et le conseil aux patients dans le domaine de l'asthme et de l'hypertension artérielle pulmonaire

Author: S. Renet, M.-C. Chaumais, M. Gallant-Dewavrin, E. Jouet, Y. Bezie, M. Humbert, A. Rieutord, O. Las Vergnas, CREF: Équipe Apprenance et Formation des Adultes, Centre de recherches éducation et formation (CREF), Université Paris Nanterre (UPN)-Université Paris Nanterre (UPN), Groupe Hospitalier Paris Saint Joseph, Faculté de Pharmacie [Châtenay-Malabry], Université Paris-Sud - Paris 11 - Faculté de médecine (UP11 UFR Médecine), Université Paris-Sud - Paris 11 (UP11)-Université Paris-Sud - Paris 11 (UP11)-Université Paris-Saclay, HTaPFrance, Association of Patients, Caregivers and Lung Transplants, Paris, France (HTaPFrance, ), Laboratoire de recherche en Santé Mentale, et Sciences Humaines et Sociales (Labo SM-SH) GHU Psychiatrie et Neurosciences - Paris, Université de Tours - François Rabelais, Assistance Publique - Hôpitaux de Paris (AP-HP), Department of Respiratory and Intensive Care Medicine, French Pulmonary Hypertension Reference Center, Hôpital Bicêtre, Le Kremlin-Bicêtre, France, Institut Gustave Roussy (IGR), Département de pharmacie clinique [Gustave Roussy], Trigone-CIREL, Centre Interuniversitaire de Recherche en Education de Lille - ULR 4354 (CIREL), and Université de Lille-Université de Lille
Subjects: Counseling, Pharmacology, Pulmonary Arterial Hypertension, Mixed methods, [SHS.STAT]Humanities and Social Sciences/Methods and statistics, Attitude of Health Personnel, [SHS.EDU]Humanities and Social Sciences/Education, Pharmaceutical Science, Community Pharmacy Services, Pharmacists, Soins chroniques, Asthma, Soins pharmaceutiques, Correspondence analysis, Professional Role, Pharmaceutical care, Patient Education as Topic, Méthodes mixtes, Éducation et conseil, Humans, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Education and counselling, Analyse des correspondances, Chronic care
Abstract: International audience; Objectives: To better understand the role of pharmacists in patient education and counselling: describe the perception of knowledge exchange (KE) between asthma/pulmonary arterial hypertension patients and pharmacists (hospital/community) according to four dimensions (4C-typology): Cure (C1), Care (C2); Coordination/supply chain (C3), Characteristics of the pathophysiology/disease mechanisms (C4); factors correlated with KE.Methods: A mixed-methods approach was used. Part A: data from semi-structured patient interviews were processed (thematic analysis), and a questionnaire developed. Part B: completed patient questionnaires were processed by correspondence factor analysis.Results: KE (4C-typology) was correlated with pathology, disease severity, disease duration, age, hospital/community pharmacist. Patients expected pharmacists to provide C2/C3 services. KE with pharmacists covered C1/C2/C3, and with physicians, C1/C2/C4. While patients perceived KE as a means of self-learning to improve self-care skills, the two-way nature meant it provided specific experiential information feedback to pharmacists.Conclusions: This 4C-typology provides a holistic framework for optimising the pharmacists’ role in education and counselling of patients with chronic diseases.; Objectifs : Mieux comprendre le rôle des pharmaciens dans l'éducation et le conseil aux patients : décrire la perception de l'échange de savoirs (ES) entre les patients asthmatiques/hypertenseurs artériels pulmonaires et les pharmaciens (hôpital/communauté) selon quatre dimensions (typologie 4C) : Cure (C1), Soins (C2) ; Coordination/chaîne d'approvisionnement (C3), Caractéristiques de la physiopathologie/mécanismes de la maladie (C4) ; facteurs corrélés avec les ES.Méthodes : Une approche mixte a été utilisée. Partie A : les données des entretiens semi-structurés avec les patients ont été traitées (analyse thématique), et un questionnaire a été élaboré. Partie B : les questionnaires remplis par les patients ont été traités par une analyse factorielle des correspondances.Résultats : Les ES (typologie 4C) était corrélée avec la pathologie, la gravité de la maladie, la durée de la maladie, l'âge, le pharmacien hospitalier/communautaire. Les patients s'attendaient à ce que les pharmaciens fournissent des services C2/C3. Les ES avec les pharmaciens couvrait C1/C2/C3, et avec les médecins, C1/C2/C4. Alors que les patients percevaient les ES comme un moyen d'auto-apprentissage pour améliorer leurs compétences en matière de soins personnels, la nature bidirectionnelle des ES a permis de fournir un retour d'information expérientiel spécifique aux pharmaciens.Conclusions : Cette typologie 4C fournit un cadre holistique pour optimiser le rôle des pharmaciens dans l'éducation et le conseil des patients atteints de maladies chroniques.
Published: 2022

30. DUNE Collaboration

Author: Abi, B., Acciarri, R., Acero, M.A., Adamov, G., Adams, D., Adinolfi, M., Ahmad, Z., Ahmed, J., Alion, T., Alonso Monsalve, S., Alt, C., Anderson, J., Andreopoulos, C., Andrews, M.P., Andrianala, F., Andringa, S., Ankowski, A., Antonova, M., Antusch, S., Aranda-Fernandez, A., Ariga, A., Arnold, L.O., Arroyave, M.A., Asaadi, J., Aurisano, A., Aushev, V., Autiero, D., Azfar, F., Back, H., Back, J.J., Backhouse, C., Baesso, P., Bagby, L., Bajou, R., Balasubramanian, S., Baldi, P., Bambah, B., Barao, F., Barenboim, G., Barker, G.J., Barkhouse, W., Barnes, C., Barr, G., Barranco Monarca, J., Barros, N., Barrow, J.L., Bashyal, A., Basque, V., Bay, F., Bazo Alba, J.L., Beacom, J.F., Bechetoille, E., Behera, B., Bellantoni, L., Bellettini, G., Bellini, V., Beltramello, O., Belver, D., Benekos, N., Bento Neves, F., Berger, J., Berkman, S., Bernardini, P., Berner, R.M., Berns, H., Bertolucci, S., Betancourt, M., Bezawada, Y., Bhattacharjee, M., Bhuyan, B., Biagi, S., Bian, J., Biassoni, M., Biery, K., Bilki, B., Bishai, M., Bitadze, A., Blake, A., Blanco Siffert, B., Blaszczyk, F.D.M., Blazey, G.C., Blucher, E., Boissevain, J., Bolognesi, S., Bolton, T., Bonesini, M., Bongrand, M., Bonini, F., Booth, A., Booth, C., Bordoni, S., Borkum, A., Boschi, T., Bostan, N., Bour, P., Boyd, S.B., Boyden, D., Bracinik, J., Braga, D., Brailsford, D., Brandt, A., Bremer, J., Brew, C., Brianne, E., Brice, S.J., Brizzolari, C., Bromberg, C., Brooijmans, G., Brooke, J., Bross, A., Brunetti, G., Buchanan, N., Budd, H., Caiulo, D., Calafiura, P., Calcutt, J., Calin, M., Calvez, S., Calvo, E., Camilleri, L., Caminata, A., Campanelli, M., Caratelli, D., Carini, G., Carlus, B., Carniti, P., Caro Terrazas, I., Carranza, H., Castillo, A., Castromonte, C., Cattadori, C., Cavalier, F., Cavanna, F., Centro, S., Cerati, G., Cervelli, A., Cervera Villanueva, A., Chalifour, M., Chang, C., Chardonnet, E., Chatterjee, A., Chattopadhyay, S., Chaves, J., Chen, H., Chen, M., Chen, Y., Cherdack, D., Chi, C., Childress, S., Chiriacescu, A., Cho, K., Choubey, S., Christensen, A., Christian, D., Christodoulou, G., Church, E., Clarke, P., Coan, T.E., Cocco, A.G., Coelho, J.A.B., Conley, E., Conrad, J.M., Convery, M., Corwin, L., Cotte, P., Cremaldi, L., Cremonesi, L., Crespo-Anadón, J.I., Cristaldo, E., Cross, R., Cuesta, C., Cui, Y., Cussans, D., Dabrowski, M., da Motta, H., Da Silva Peres, L., David, C., David, Q., Davies, G.S., Davini, S., Dawson, J., De, K., De Almeida, R.M., Debbins, P., De Bonis, I., Decowski, M.P., de Gouvêa, A., De Holanda, P.C., De Icaza Astiz, I.L., Deisting, A., De Jong, P., Delbart, A., Delepine, D., Delgado, M., Dell'Acqua, A., De Lurgio, P., de Mello Neto, J.R.T., DeMuth, D.M., Dennis, S., Densham, C., Deptuch, G., De Roeck, A., De Romeri, V., De Vries, J.J., Dharmapalan, R., Dias, M., Diaz, F., Díaz, J.S., Di Domizio, S., Di Giulio, L., Ding, P., Di Noto, L., Distefano, C., Diurba, R., Diwan, M., Djurcic, Z., Dokania, N., Dolinski, M.J., Domine, L., Douglas, D., Drielsma, F., Duchesneau, D., Duffy, K., Dunne, P., Durkin, T., Duyang, H., Dvornikov, O., Dwyer, D.A., Dyshkant, A.S., Eads, M., Edmunds, D., Eisch, J., Emery, S., Ereditato, A., Escobar, C.O., Escudero Sanchez, L., Evans, J.J., Ewart, E., Ezeribe, A.C., Fahey, K., Falcone, A., Farnese, C., Farzan, Y., Felix, J., Fernandez-Martinez, E., Fernandez Menendez, P., Ferraro, F., Fields, L., Filkins, A., Filthaut, F., Fitzpatrick, R.S., Flanagan, W., Fleming, B., Flight, R., Fowler, J., Fox, W., Franc, J., Francis, K., Franco, D., Freeman, J., Freestone, J., Fried, J., Friedland, A., Fuess, S., Furic, I., Furmanski, A.P., Gago, A., Gallagher, H., Gallego-Ros, A., Gallice, N., Galymov, V., Gamberini, E., Gamble, T., Gandhi, R., Gandrajula, R., Gao, S., Garcia-Gamez, D., García-Peris, M.Á., Gardiner, S., Gastler, D., Ge, G., Gelli, B., Gendotti, A., Gent, S., Ghorbani-Moghaddam, Z., Gibin, D., Gil-Botella, I., Girerd, C., Giri, A.K., Gnani, D., Gogota, O., Gold, M., Gollapinni, S., Gollwitzer, K., Gomes, R.A., Gomez Bermeo, L.V., Gomez Fajardo, L.S., Gonnella, F., Gonzalez-Cuevas, J.A., Goodman, M.C., Goodwin, O., Goswami, S., Gotti, C., Goudzovski, E., Grace, C., Graham, M., Gramellini, E., Gran, R., Granados, E., Grant, A., Grant, C., Gratieri, D., Green, P., Green, S., Greenler, L., Greenwood, M., Greer, J., Griffith, W.C., Groh, M., Grudzinski, J., Grzelak, K., Gu, W., Guarino, V., Guenette, R., Guglielmi, A., Guo, B., Guthikonda, K.K., Gutierrez, R., Guzowski, P., Guzzo, M.M., Gwon, S., Habig, A., Hackenburg, A., Hadavand, H., Haenni, R., Hahn, A., Haigh, J., Haiston, J., Hamernik, T., Hamilton, P., Han, J., Harder, K., Harris, D.A., Hartnell, J., Hasegawa, T., Hatcher, R., Hazen, E., Heavey, A., Heeger, K.M., Heise, J., Hennessy, K., Henry, S., Hernandez Morquecho, M.A., Herner, K., Hertel, L., Hesam, A.S., Hewes, V., Hewes, J., Higuera, A., Hill, T., Hillier, S.J., Himmel, A., Hoff, J., Hohl, C., Holin, A., Hoppe, E., Horton-Smith, G.A., Hostert, M., Hourlier, A., Howard, B., Howell, R., Huang, J., Hugon, J., Iles, G., Ilic, N., Iliescu, A.M., Illingworth, R., Ioannisian, A., Itay, R., Izmaylov, A., James, E., Jargowsky, B., Jediny, F., Jesùs-Valls, C., Ji, X., Jiang, L., Jiménez, S., Jipa, A., Joglekar, A., Johnson, C., Johnson, R., Jones, B., Jones, S., Jung, C.K., Junk, T., Jwa, Y., Kabirnezhad, M., Kaboth, A., Kadenko, I., Kamiya, F., Karagiorgi, G., Karcher, A., Karolak, M., Karyotakis, Y., Kasai, S., Kasetti, S.P., Kashur, L., Kazaryan, N., Kearns, E., Keener, P., Kelly, K.J., Kemp, E., Ketchum, W., Kettell, S.H., Khabibullin, M., Khotjantsev, A., Khvedelidze, A., Kim, D., King, B., Kirby, B., Kirby, M., Klein, J., Koehler, K., Koerner, L.W., Kohn, S., Koller, P.P., Kordosky, M., Kosc, T., Kose, U., Kostelecký, V.A., Kothekar, K., Krennrich, F., Kreslo, I., Kudenko, Y., Kudryavtsev, V.A., Kulagin, S., Kumar, J., Kumar, R., Kuruppu, C., Kus, V., Kutter, T., Lambert, A., Lande, K., Lane, C.E., Lang, K., Langford, T., Lasorak, P., Last, D., Lastoria, C., Laundrie, A., Lawrence, A., Lazanu, I., LaZur, R., Le, T., Learned, J., LeBrun, P., Lehmann Miotto, G., Lehnert, R., Leigui de Oliveira, M.A., Leitner, M., Leyton, M., Li, L., Li, S., Li, S.W., Li, T., Li, Y., Liao, H., Lin, C.S., Lin, S., Lister, A., Littlejohn, B.R., Liu, J., Lockwitz, S., Loew, T., Lokajicek, M., Lomidze, I., Long, K., Loo, K., Lorca, D., Lord, T., LoSecco, J.M., Louis, W.C., Luk, K.B., Luo, X., Lurkin, N., Lux, T., Luzio, V.P., MacFarlane, D., Machado, A.A., Machado, P., Macias, C.T., Macier, J.R., Maddalena, A., Madigan, P., Magill, S., Mahn, K., Maio, A., Maloney, J.A., Mandrioli, G., Maneira, J., Manenti, L., Manly, S., Mann, A., Manolopoulos, K., Manrique Plata, M., Marchionni, A., Marciano, W., Marfatia, D., Mariani, C., Maricic, J., Marinho, F., Marino, A.D., Marshak, M., Marshall, C., Marshall, J., Marteau, J., Martin-Albo, J., Martinez, N., Martinez Caicedo, D.A., Martynenko, S., Mason, K., Mastbaum, A., Masud, M., Matsuno, S., Matthews, J., Mauger, C., Mauri, N., Mavrokoridis, K., Mazza, R., Mazzacane, A., Mazzucato, E., McCluskey, E., McConkey, N., McFarland, K.S., McGrew, C., McNab, A., Mefodiev, A., Mehta, P., Melas, P., Mellinato, M., Mena, O., Menary, S., Mendez, H., Menegolli, A., Meng, G., Messier, M.D., Metcalf, W., Mewes, M., Meyer, H., Miao, T., Michna, G., Miedema, T., Migenda, J., Milincic, R., Miller, W., Mills, J., Milne, C., Mineev, O., Miranda, O.G., Miryala, S., Mishra, C.S., Mishra, S.R., Mislivec, A., Mladenov, D., Mocioiu, I., Moffat, K., Moggi, N., Mohanta, R., Mohayai, T.A., Mokhov, N., Molina, J., Molina Bueno, L., Montanari, A., Montanari, C., Montanari, D., Montano Zetina, L.M., Moon, J., Mooney, M., Moor, A., Moreno, D., Morgan, B., Morris, C., Mossey, C., Motuk, E., Moura, C.A., Mousseau, J., Mu, W., Mualem, L., Mueller, J., Muether, M., Mufson, S., Muheim, F., Muir, A., Mulhearn, M., Muramatsu, H., Murphy, S., Musser, J., Nachtman, J., Nagu, S., Nalbandyan, M., Nandakumar, R., Naples, D., Narita, S., Navas-Nicolás, D., Nayak, N., Nebot-Guinot, M., Necib, L., Negishi, K., Nelson, J.K., Nesbit, J., Nessi, M., Newbold, D., Newcomer, M., Newhart, D., Nichol, R., Niner, E., Nishimura, K., Norman, A., Norrick, A., Northrop, R., Novella, P., Nowak, J.A., Oberling, M., Olivares Del Campo, A., Olivier, A., Onel, Y., Onishchuk, Y., Ott, J., Pagani, L., Pakvasa, S., Palamara, O., Palestini, S., Paley, J.M., Pallavicini, M., Palomares, C., Pantic, E., Paolone, V., Papadimitriou, V., Papaleo, R., Papanestis, A., Paramesvaran, S., Park, J.C., Parke, S., Parsa, Z., Parvu, M., Pascoli, S., Pasqualini, L., Pasternak, J., Pater, J., Patrick, C., Patrizii, L., Patterson, R.B., Patton, S.J., Patzak, T., Paudel, A., Paulos, B., Paulucci, L., Pavlovic, Z., Pawloski, G., Payne, D., Pec, V., Peeters, S.J.M., Penichot, Y., Pennacchio, E., Penzo, A., Peres, O.L.G., Perry, J., Pershey, D., Pessina, G., Petrillo, G., Petta, C., Petti, R., Piastra, F., Pickering, L., Pietropaolo, F., Pillow, J., Pinzino, J., Plunkett, R., Poling, R., Pons, X., Poonthottathil, N., Pordes, S., Potekhin, M., Potenza, R., Potukuchi, B.V.K.S., Pozimski, J., Pozzato, M., Prakash, S., Prakash, T., Prince, S., Prior, G., Pugnere, D., Qi, K., Qian, X., Raaf, J.L., Raboanary, R., Radeka, V., Rademacker, J., Radics, B., Rafique, A., Raguzin, E., Rai, M., Rajaoalisoa, M., Rakhno, I., Rakotondramanana, H.T., Rakotondravohitra, L., Ramachers, Y.A., Rameika, R., Ramirez Delgado, M.A., Ramson, B., Rappoldi, A., Raselli, G., Ratoff, P., Ravat, S., Razafinime, H., Real, J.S., Rebel, B., Redondo, D., Reggiani-Guzzo, M., Rehak, T., Reichenbacher, J., Reitzner, S.D., Renshaw, A., Rescia, S., Resnati, F., Reynolds, A., Riccobene, G., Rice, L.C.J., Rielage, K., Rigaut, Y., Rivera, D., Rochester, L., Roda, M., Rodrigues, P., Rodriguez Alonso, M.J., Rodriguez Rondon, J., Roeth, A.J., Rogers, H., Rosauro-Alcaraz, S., Rossella, M., Rout, J., Roy, S., Rubbia, A., Rubbia, C., Russell, B., Russell, J., Ruterbories, D., Saakyan, R., Sacerdoti, S., Safford, T., Sahu, N., Sala, P., Samios, N., Sanchez, M.C., Sanders, D.A., Sankey, D., Santana, S., Santos-Maldonado, M., Saoulidou, N., Sapienza, P., Sarasty, C., Sarcevic, I., Savage, G., Savinov, V., Scaramelli, A., Scarff, A., Scarpelli, A., Schaffer, T., Schellman, H., Schlabach, P., Schmitz, D., Scholberg, K., Schukraft, A., Segreto, E., Sensenig, J., Seong, I., Sergi, A., Sergiampietri, F., Sgalaberna, D., Shaevitz, M.H., Shafaq, S., Shamma, M., Sharma, H.R., Sharma, R., Shaw, T., Shepherd-Themistocleous, C., Shin, S., Shooltz, D., Shrock, R., Simard, L., Simos, N., Sinclair, J., Sinev, G., Singh, J., Singh, V., Sipos, R., Sippach, F.W., Sirri, G., Sitraka, A., Siyeon, K., Smargianaki, D., Smith, A., Smith, E., Smith, P., Smolik, J., Smy, M., Snopok, P., Soares Nunes, M., Sobel, H., Soderberg, M., Solano Salinas, C.J., Söldner-Rembold, S., Solomey, N., Solovov, V., Sondheim, W.E., Sorel, M., Soto-Oton, J., Sousa, A., Soustruznik, K., Spagliardi, F., Spanu, M., Spitz, J., Spooner, N.J.C., Spurgeon, K., Staley, R., Stancari, M., Stanco, L., Steiner, H.M., Stewart, J., Stillwell, B., Stock, J., Stocker, F., Stocks, D., Stokes, T., Strait, M., Strauss, T., Striganov, S., Stuart, A., Summers, D., Surdo, A., Susic, V., Suter, L., Sutera, C.M., Svoboda, R., Szczerbinska, B., Szelc, A.M., Talaga, R., Tanaka, H.A., Tapia Oregui, B., Tapper, A., Tariq, S., Tatar, E., Tayloe, R., Teklu, A.M., Tenti, M., Terao, K., Ternes, C.A., Terranova, F., Testera, G., Thea, A., Thompson, J.L., Thorn, C., Timm, S.C., Todd, J., Tonazzo, A., Torti, M., Tortola, M., Tortorici, F., Totani, D., Toups, M., Touramanis, C., Trevor, J., Trzaska, W.H., Tsai, Y.-T., Tsamalaidze, Z., Tsang, K.V., Tsverava, N., Tufanli, S., Tull, C., Tyley, E., Tzanov, M., Uchida, M.A., Urheim, J., Usher, T., Vagins, M.R., Vahle, P., Valdiviesso, G.A., Valencia, E., Vallari, Z., Valle, J.W.F., Vallecorsa, S., Van Berg, R., Van de Water, R.G., Vanegas Forero, D., Varanini, F., Vargas, D., Varner, G., Vasel, J., Vasseur, G., Vaziri, K., Ventura, S., Verdugo, A., Vergani, S., Vermeulen, M.A., Verzocchi, M., Vieira de Souza, H., Vignoli, C., Vilela, C., Viren, B., Vrba, T., Wachala, T., Waldron, A.V., Wallbank, M., Wang, H., Wang, J., Wang, Y., Warburton, K., Warner, D., Wascko, M., Waters, D., Watson, A., Weatherly, P., Weber, A., Weber, M., Wei, H., Weinstein, A., Wenman, D., Wetstein, M., While, M.R., White, A., Whitehead, L.H., Whittington, D., Wilking, M.J., Wilkinson, C., Williams, Z., Wilson, F., Wilson, R.J., Wolcott, J., Wongjirad, T., Wood, K., Wood, L., Worcester, E., Worcester, M., Wret, C., Wu, W., Xiao, Y., Yang, G., Yang, T., Yershov, N., Yonehara, K., Young, T., Yu, B., Yu, J., Zaki, R., Zalesak, J., Zambelli, L., Zamorano, B., Zani, A., Zazueta, L., Zeller, G.P., Zennamo, J., Zeug, K., Zhang, C., Zhao, M., Zhao, Y., Zhivun, E., Zhu, G., Zimmerman, E.D., Zito, M., Zucchelli, S., Zuklin, J., Zutshi, V., Zwaska, R., Institut de Physique des 2 Infinis de Lyon (IP2I Lyon), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), DUNE, Apollo - University of Cambridge Repository, Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Abi, B., Acciarri, R., Acero, M. A., Adamov, G., Adams, D., Adinolfi, M., Ahmad, Z., Ahmed, J., Alion, T., Monsalve, S. Alonso, Alt, C., Anderson, J., Andreopoulos, C., Andrews, M. P., Andrianala, F., Andringa, S., Ankowski, A., Antonova, M., Antusch, S., Aranda-Fernandez, A., Ariga, A., Arnold, L. O., Arroyave, M. A., Asaadi, J., Aurisano, A., Aushev, V., Autiero, D., Azfar, F., Back, H., Back, J. J., Backhouse, C., Baesso, P., Bagby, L., Bajou, R., Balasubramanian, S., Baldi, P., Bambah, B., Barao, F., Barenboim, G., Barker, G. J., Barkhouse, W., Barnes, C., Barr, G., Monarca, J. Barranco, Barros, N., Barrow, J. L., Bashyal, A., Basque, V., Bay, F., Alba, J. L. Bazo, Beacom, J. F., Bechetoille, E., Behera, B., Bellantoni, L., Bellettini, G., Bellini, V., Beltramello, O., Belver, D., Benekos, N., Neves, F. Bento, Berger, J., Berkman, S., Bernardini, P., Berner, R. M., Berns, H., Bertolucci, S., Betancourt, M., Bezawada, Y., Bhattacharjee, M., Bhuyan, B., Biagi, S., Bian, J., Biassoni, M., Biery, K., Bilki, B., Bishai, M., Bitadze, A., Blake, A., Siffert, B. Blanco, Blaszczyk, F. D. M., Blazey, G. C., Blucher, E., Boissevain, J., Bolognesi, S., Bolton, T., Bonesini, M., Bongrand, M., Bonini, F., Booth, A., Booth, C., Bordoni, S., Borkum, A., Boschi, T., Bostan, N., Bour, P., Boyd, S. B., Boyden, D., Bracinik, J., Braga, D., Brailsford, D., Brandt, A., Bremer, J., Brew, C., Brianne, E., Brice, S. J., Brizzolari, C., Bromberg, C., Brooijmans, G., Brooke, J., Bross, A., Brunetti, G., Buchanan, N., Budd, H., Caiulo, D., Calafiura, P., Calcutt, J., Calin, M., Calvez, S., Calvo, E., Camilleri, L., Caminata, A., Campanelli, M., Caratelli, D., Carini, G., Carlus, B., Carniti, P., Terrazas, I. Caro, Carranza, H., Castillo, A., Castromonte, C., Cattadori, C., Cavalier, F., Cavanna, F., Centro, S., Cerati, G., Cervelli, A., Villanueva, A. Cervera, Chalifour, M., Chang, C., Chardonnet, E., Chatterjee, A., Chattopadhyay, S., Chaves, J., Chen, H., Chen, M., Chen, Y., Cherdack, D., Chi, C., Childress, S., Chiriacescu, A., Cho, K., Choubey, S., Christensen, A., Christian, D., Christodoulou, G., Church, E., Clarke, P., Coan, T. E., Cocco, A. G., Coelho, J. A. B., Conley, E., Conrad, J. M., Convery, M., Corwin, L., Cotte, P., Cremaldi, L., Cremonesi, L., Crespo-Anadón, J. I., Cristaldo, E., Cross, R., Cuesta, C., Cui, Y., Cussans, D., Dabrowski, M., da Motta, H., Peres, L. Da Silva, David, C., David, Q., Davies, G. S., Davini, S., Dawson, J., De, K., De Almeida, R. M., Debbins, P., De Bonis, I., Decowski, M. P., de Gouvêa, A., De Holanda, P. C., De Icaza Astiz, I. L., Deisting, A., De Jong, P., Delbart, A., Delepine, D., Delgado, M., Dell’Acqua, A., De Lurgio, P., De, Mello&nbsp, Neto, J. R. T., Demuth, D. M., Dennis, S., Densham, C., Deptuch, G., De Roeck, A., De Romeri, V., De Vries, J. J., Dharmapalan, R., Dias, M., Diaz, F., Díaz, J. S., Di Domizio, S., Di Giulio, L., Ding, P., Di Noto, L., Distefano, C., Diurba, R., Diwan, M., Djurcic, Z., Dokania, N., Dolinski, M. J., Domine, L., Douglas, D., Drielsma, F., Duchesneau, D., Duffy, K., Dunne, P., Durkin, T., Duyang, H., Dvornikov, O., Dwyer, D. A., Dyshkant, A. S., Eads, M., Edmunds, D., Eisch, J., Emery, S., Ereditato, A., Escobar, C. O., Sanchez, L. Escudero, Evans, J. J., Ewart, E., Ezeribe, A. C., Fahey, K., Falcone, A., Farnese, C., Farzan, Y., Felix, J., Fernandez-Martinez, E., Fernandez Menendez, P., Ferraro, F., Fields, L., Filkins, A., Filthaut, F., Fitzpatrick, R. S., Flanagan, W., Fleming, B., Flight, R., Fowler, J., Fox, W., Franc, J., Francis, K., Franco, D., Freeman, J., Freestone, J., Fried, J., Friedland, A., Fuess, S., Furic, I., Furmanski, A. P., Gago, A., Gallagher, H., Gallego-Ros, A., Gallice, N., Galymov, V., Gamberini, E., Gamble, T., Gandhi, R., Gandrajula, R., Gao, S., Garcia-Gamez, D., García-Peris, M. Á., Gardiner, S., Gastler, D., Ge, G., Gelli, B., Gendotti, A., Gent, S., Ghorbani-Moghaddam, Z., Gibin, D., Gil-Botella, I., Girerd, C., Giri, A. K., Gnani, D., Gogota, O., Gold, M., Gollapinni, S., Gollwitzer, K., Gomes, R. A., Bermeo, L. V. Gomez, Fajardo, L. S. Gomez, Gonnella, F., Gonzalez-Cuevas, J. A., Goodman, M. C., Goodwin, O., Goswami, S., Gotti, C., Goudzovski, E., Grace, C., Graham, M., Gramellini, E., Gran, R., Granados, E., Grant, A., Grant, C., Gratieri, D., Green, P., Green, S., Greenler, L., Greenwood, M., Greer, J., Griffith, W. C., Groh, M., Grudzinski, J., Grzelak, K., Gu, W., Guarino, V., Guenette, R., Guglielmi, A., Guo, B., Guthikonda, K. K., Gutierrez, R., Guzowski, P., Guzzo, M. M., Gwon, S., Habig, A., Hackenburg, A., Hadavand, H., Haenni, R., Hahn, A., Haigh, J., Haiston, J., Hamernik, T., Hamilton, P., Han, J., Harder, K., Harris, D. A., Hartnell, J., Hasegawa, T., Hatcher, R., Hazen, E., Heavey, A., Heeger, K. M., Heise, J., Hennessy, K., Henry, S., Morquecho, M. A. Hernandez, Herner, K., Hertel, L., Hesam, A. S., Hewes, J., Higuera, A., Hill, T., Hillier, S. J., Himmel, A., Hoff, J., Hohl, C., Holin, A., Hoppe, E., Horton-Smith, G. A., Hostert, M., Hourlier, A., Howard, B., Howell, R., Huang, J., Hugon, J., Iles, G., Ilic, N., Iliescu, A. M., Illingworth, R., Ioannisian, A., Itay, R., Izmaylov, A., James, E., Jargowsky, B., Jediny, F., Jesùs-Valls, C., Ji, X., Jiang, L., Jiménez, S., Jipa, A., Joglekar, A., Johnson, C., Johnson, R., Jones, B., Jones, S., Jung, C. K., Junk, T., Jwa, Y., Kabirnezhad, M., Kaboth, A., Kadenko, I., Kamiya, F., Karagiorgi, G., Karcher, A., Karolak, M., Karyotakis, Y., Kasai, S., Kasetti, S. P., Kashur, L., Kazaryan, N., Kearns, E., Keener, P., Kelly, K. J., Kemp, E., Ketchum, W., Kettell, S. H., Khabibullin, M., Khotjantsev, A., Khvedelidze, A., Kim, D., King, B., Kirby, B., Kirby, M., Klein, J., Koehler, K., Koerner, L. W., Kohn, S., Koller, P. P., Kordosky, M., Kosc, T., Kose, U., Kostelecký, V. A., Kothekar, K., Krennrich, F., Kreslo, I., Kudenko, Y., Kudryavtsev, V. A., Kulagin, S., Kumar, J., Kumar, R., Kuruppu, C., Kus, V., Kutter, T., Lambert, A., Lande, K., Lane, C. E., Lang, K., Langford, T., Lasorak, P., Last, D., Lastoria, C., Laundrie, A., Lawrence, A., Lazanu, I., Lazur, R., Le, T., Learned, J., Lebrun, P., Miotto, G. Lehmann, Lehnert, R., de Oliveira, M. A. Leigui, Leitner, M., Leyton, M., Li, L., Li, S., Li, S. W., Li, T., Li, Y., Liao, H., Lin, C. S., Lin, S., Lister, A., Littlejohn, B. R., Liu, J., Lockwitz, S., Loew, T., Lokajicek, M., Lomidze, I., Long, K., Loo, K., Lorca, D., Lord, T., Losecco, J. M., Louis, W. C., Luk, K. B., Luo, X., Lurkin, N., Lux, T., Luzio, V. P., Macfarland, D., Machado, A. A., Machado, P., Macias, C. T., Macier, J. R., Maddalena, A., Madigan, P., Magill, S., Mahn, K., Maio, A., Maloney, J. A., Mandrioli, G., Maneira, J., Manenti, L., Manly, S., Mann, A., Manolopoulos, K., Plata, M. Manrique, Marchionni, A., Marciano, W., Marfatia, D., Mariani, C., Maricic, J., Marinho, F., Marino, A. D., Marshak, M., Marshall, C., Marshall, J., Marteau, J., Martin-Albo, J., Martinez, N., Caicedo, D. A. Martinez, Martynenko, S., Mason, K., Mastbaum, A., Masud, M., Matsuno, S., Matthews, J., Mauger, C., Mauri, N., Mavrokoridis, K., Mazza, R., Mazzacane, A., Mazzucato, E., Mccluskey, E., Mcconkey, N., Mcfarland, K. S., Mcgrew, C., Mcnab, A., Mefodiev, A., Mehta, P., Melas, P., Mellinato, M., Mena, O., Menary, S., Mendez, H., Menegolli, A., Meng, G., Messier, M. D., Metcalf, W., Mewes, M., Meyer, H., Miao, T., Michna, G., Miedema, T., Migenda, J., Milincic, R., Miller, W., Mills, J., Milne, C., Mineev, O., Miranda, O. G., Miryala, S., Mishra, C. S., Mishra, S. R., Mislivec, A., Mladenov, D., Mocioiu, I., Moffat, K., Moggi, N., Mohanta, R., Mohayai, T. A., Mokhov, N., Molina, J., Bueno, L. Molina, Montanari, A., Montanari, C., Montanari, D., Zetina, L. M. Montano, Moon, J., Mooney, M., Moor, A., Moreno, D., Morgan, B., Morris, C., Mossey, C., Motuk, E., Moura, C. A., Mousseau, J., Mu, W., Mualem, L., Mueller, J., Muether, M., Mufson, S., Muheim, F., Muir, A., Mulhearn, M., Muramatsu, H., Murphy, S., Musser, J., Nachtman, J., Nagu, S., Nalbandyan, M., Nandakumar, R., Naples, D., Narita, S., Navas-Nicolás, D., Nayak, N., Nebot-Guinot, M., Necib, L., Negishi, K., Nelson, J. K., Nesbit, J., Nessi, M., Newbold, D., Newcomer, M., Newhart, D., Nichol, R., Niner, E., Nishimura, K., Norman, A., Norrick, A., Northrop, R., Novella, P., Nowak, J. A., Oberling, M., Del Campo, A. Olivare, Olivier, A., Onel, Y., Onishchuk, Y., Ott, J., Pagani, L., Pakvasa, S., Palamara, O., Palestini, S., Paley, J. M., Pallavicini, M., Palomares, C., Pantic, E., Paolone, V., Papadimitriou, V., Papaleo, R., Papanestis, A., Paramesvaran, S., Park, J. C., Parke, S., Parsa, Z., Parvu, M., Pascoli, S., Pasqualini, L., Pasternak, J., Pater, J., Patrick, C., Patrizii, L., Patterson, R. B., Patton, S. J., Patzak, T., Paudel, A., Paulos, B., Paulucci, L., Pavlovic, Z., Pawloski, G., Payne, D., Pec, V., Peeters, S. J. M., Penichot, Y., Pennacchio, E., Penzo, A., Peres, O. L. G., Perry, J., Pershey, D., Pessina, G., Petrillo, G., Petta, C., Petti, R., Piastra, F., Pickering, L., Pietropaolo, F., Pillow, J., Pinzino, J., Plunkett, R., Poling, R., Pons, X., Poonthottathil, N., Pordes, S., Potekhin, M., Potenza, R., Potukuchi, B. V. K. S., Pozimski, J., Pozzato, M., Prakash, S., Prakash, T., Prince, S., Prior, G., Pugnere, D., Qi, K., Qian, X., Raaf, J. L., Raboanary, R., Radeka, V., Rademacker, J., Radics, B., Rafique, A., Raguzin, E., Rai, M., Rajaoalisoa, M., Rakhno, I., Rakotondramanana, H. T., Rakotondravohitra, L., Ramachers, Y. A., Rameika, R., Delgado, M. A. Ramirez, Ramson, B., Rappoldi, A., Raselli, G., Ratoff, P., Ravat, S., Razafinime, H., Real, J. S., Rebel, B., Redondo, D., Reggiani-Guzzo, M., Rehak, T., Reichenbacher, J., Reitzner, S. D., Renshaw, A., Rescia, S., Resnati, F., Reynolds, A., Riccobene, G., Rice, L. C. J., Rielage, K., Rigaut, Y., Rivera, D., Rochester, L., Roda, M., Rodrigues, P., Alonso, M. J. Rodriguez, Rondon, J. Rodriguez, Roeth, A. J., Rogers, H., Rosauro-Alcaraz, S., Rossella, M., Rout, J., Roy, S., Rubbia, A., Rubbia, C., Russell, B., Russell, J., Ruterbories, D., Saakyan, R., Sacerdoti, S., Safford, T., Sahu, N., Sala, P., Samios, N., Sanchez, M. C., Sanders, D. A., Sankey, D., Santana, S., Santos-Maldonado, M., Saoulidou, N., Sapienza, P., Sarasty, C., Sarcevic, I., Savage, G., Savinov, V., Scaramelli, A., Scarff, A., Scarpelli, A., Schaffer, T., Schellman, H., Schlabach, P., Schmitz, D., Scholberg, K., Schukraft, A., Segreto, E., Sensenig, J., Seong, I., Sergi, A., Sergiampietri, F., Sgalaberna, D., Shaevitz, M. H., Shafaq, S., Shamma, M., Sharma, H. R., Sharma, R., Shaw, T., Shepherd-Themistocleous, C., Shin, S., Shooltz, D., Shrock, R., Simard, L., Simos, N., Sinclair, J., Sinev, G., Singh, J., Singh, V., Sipos, R., Sippach, F. W., Sirri, G., Sitraka, A., Siyeon, K., Smargianaki, D., Smith, A., Smith, E., Smith, P., Smolik, J., Smy, M., Snopok, P., Nunes, M. Soare, Sobel, H., Soderberg, M., Salinas, C. J. Solano, Söldner-Rembold, S., Solomey, N., Solovov, V., Sondheim, W. E., Sorel, M., Soto-Oton, J., Sousa, A., Soustruznik, K., Spagliardi, F., Spanu, M., Spitz, J., Spooner, N. J. C., Spurgeon, K., Staley, R., Stancari, M., Stanco, L., Steiner, H. M., Stewart, J., Stillwell, B., Stock, J., Stocker, F., Stocks, D., Stokes, T., Strait, M., Strauss, T., Striganov, S., Stuart, A., Summers, D., Surdo, A., Susic, V., Suter, L., Sutera, C. M., Svoboda, R., Szczerbinska, B., Szelc, A. M., Talaga, R., Tanaka, H. A., Oregui, B. Tapia, Tapper, A., Tariq, S., Tatar, E., Tayloe, R., Teklu, A. M., Tenti, M., Terao, K., Ternes, C. A., Terranova, F., Testera, G., Thea, A., Thompson, J. L., Thorn, C., Timm, S. C., Todd, J., Tonazzo, A., Torti, M., Tortola, M., Tortorici, F., Totani, D., Toups, M., Touramanis, C., Trevor, J., Trzaska, W. H., Tsai, Y. -T., Tsamalaidze, Z., Tsang, K. V., Tsverava, N., Tufanli, S., Tull, C., Tyley, E., Tzanov, M., Uchida, M. A., Urheim, J., Usher, T., Vagins, M. R., Vahle, P., Valdiviesso, G. A., Valencia, E., Vallari, Z., Valle, J. W. F., Vallecorsa, S., Berg, R. Van, de Water, R. G. Van, Forero, D. Vanega, Varanini, F., Vargas, D., Varner, G., Vasel, J., Vasseur, G., Vaziri, K., Ventura, S., Verdugo, A., Vergani, S., Vermeulen, M. A., Verzocchi, M., de Souza, H. Vieira, Vignoli, C., Vilela, C., Viren, B., Vrba, T., Wachala, T., Waldron, A. V., Wallbank, M., Wang, H., Wang, J., Wang, Y., Warburton, K., Warner, D., Wascko, M., Waters, D., Watson, A., Weatherly, P., Weber, A., Weber, M., Wei, H., Weinstein, A., Wenman, D., Wetstein, M., While, M. R., White, A., Whitehead, L. H., Whittington, D., Wilking, M. J., Wilkinson, C., Williams, Z., Wilson, F., Wilson, R. J., Wolcott, J., Wongjirad, T., Wood, K., Wood, L., Worcester, E., Worcester, M., Wret, C., Wu, W., Xiao, Y., Yang, G., Yang, T., Yershov, N., Yonehara, K., Young, T., Yu, B., Yu, J., Zaki, R., Zalesak, J., Zambelli, L., Zamorano, B., Zani, A., Zazueta, L., Zeller, G. P., Zennamo, J., Zeug, K., Zhang, C., Zhao, M., Zhao, Y., Zhivun, E., Zhu, G., Zimmerman, E. D., Zito, M., Zucchelli, S., Zuklin, J., Zutshi, V., and Zwaska, R.
Subjects: Regular Article - Experimental Physics, Physics::Instrumentation and Detectors, far detector, FOS: Physical sciences, QC770-798, invariance: Lorentz, Astrophysics, dark matter, neutrino: flux, High Energy Physics - Experiment, DUNE, beyond Standard Model, High Energy Physics - Experiment (hep-ex), High Energy Physics - Phenomenology (hep-ph), near detector, Nuclear and particle physics. Atomic energy. Radioactivity, new interaction, lepton: heavy, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], baryon number: violation, Particle Physics - Phenomenology, hep-ex, symmetry: violation, new physics: search for, High Energy Physics::Phenomenology, hep-ph, p: beam, neutrino: sterile, sensitivity, neutrino: heavy, deep underground detector, violation: Lorentz, QB460-466, High Energy Physics - Phenomenology, neutrino: detector, CPT: conservation law, High Energy Physics::Experiment, neutrino: oscillation, proposed experiment, neutrino: mixing, Particle Physics - Experiment, new particle
Abstract: The Deep Underground Neutrino Experiment (DUNE) will be a powerful tool for a variety of physics topics. The high-intensity proton beams provide a large neutrino flux, sampled by a near detector system consisting of a combination of capable precision detectors, and by the massive far detector system located deep underground. This configuration sets up DUNE as a machine for discovery, as it enables opportunities not only to perform precision neutrino measurements that may uncover deviations from the present three-flavor mixing paradigm, but also to discover new particles and unveil new interactions and symmetries beyond those predicted in the Standard Model (SM). Of the many potential beyond the Standard Model (BSM) topics DUNE will probe, this paper presents a selection of studies quantifying DUNE's sensitivities to sterile neutrino mixing, heavy neutral leptons, non-standard interactions, CPT symmetry violation, Lorentz invariance violation, neutrino trident production, dark matter from both beam induced and cosmogenic sources, baryon number violation, and other new physics topics that complement those at high-energy colliders and significantly extend the present reach., Comment: 54 pages, 40 figures, paper based on the DUNE Technical Design Report (arXiv:2002.03005)
Published: 2021

31. When Is a Critically Ill Cirrhotic Patient Too Sick to Transplant? Development of Consensus Criteria by a Multidisciplinary Panel of 35 International Experts

Author: Samir Jaber, Thomas Reiberger, Kim M. Olthoff, Jan Lerut, Kate Kronish, François Durand, Wim Laleman, Jody C. Olson, James Y. Findlay, Sumeet K. Asrani, Dana Tomescu, Victor W. Xia, Emmanuel Weiss, Fuat H. Saner, Paolo Muiesan, Constantino Fondevila, Annabel Blasi, Catherine Paugam-Burtz, Constantine J. Karvellas, Thierry Gustot, Olivier Scatton, Ram Subramanian, Javier Fernández, Koen Reyntjens, Pierre-François Laterre, Faouzi Saliba, Kenneth J. Simpson, Gianni Biancofiore, Olivier Soubrane, Eric Levesque, Claire Francoz, Frank Tacke, Gebhard Wagener, Mark Mc Phail, Antonio Daniele Pinna, M. Susan Mandell, MORNET, Dominique, Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de recherche sur l'Inflammation (CRI (UMR_S_1149 / ERL_8252 / U1149)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), European Foundation for Study of Chronic Liver Failure [Barcelona] (EF CLIF), Universitätsklinikum Essen [Universität Duisburg-Essen] (Uniklinik Essen), Baylor University, University of Pisa - Università di Pisa, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Université Catholique de Louvain = Catholic University of Louvain (UCL), Nokia Bell Labs [Paris-Saclay], University of Barcelona, Mayo Clinic [Rochester], Universitat de Barcelona (UB), Université libre de Bruxelles (ULB), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), University of California [San Francisco] (UC San Francisco), University of California (UC), Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Centre hépato-biliaire - CHB [Paul Brousse, Paris], Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse, University of Colorado Anschutz [Aurora], King‘s College London, University of Birmingham [Birmingham], Birmingham Women's and Children's NHS Foundation Trust, University of Kansas [Kansas City], Hospital of the University of Pennsylvania (HUP), Perelman School of Medicine, University of Pennsylvania-University of Pennsylvania, University of Bologna/Università di Bologna, University of Vienna [Vienna], University of Groningen [Groningen], Physiopathologie et traitement des maladies du foie, Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Service de Chirurgie Digestive, Hépato-Bilio-pancréatique et Transplantation Hépatique [CHU Pitié-Salpétrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), University of Edinburgh, Emory University School of Medicine, Emory University [Atlanta, GA], Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Fundeni Clinical Institute = Institutul Clinic Fundeni [Bucarest, Roumanie], David Geffen School of Medicine [Los Angeles], University of California [Los Angeles] (UCLA), University of California (UC)-University of California (UC), Columbia University College of Physicians and Surgeons, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, UCL - (SLuc) Service de chirurgie et transplantation abdominale, UCL - (SLuc) Service de soins intensifs, Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), University of California [San Francisco] (UCSF), University of California, Hôpital Paul Brousse-Université Paris-Sud - Paris 11 (UP11), University of Pennsylvania [Philadelphia]-University of Pennsylvania [Philadelphia], University of Bologna, and University of California-University of California
Subjects: Liver Cirrhosis, medicine.medical_specialty, Consensus, [SDV.IMM] Life Sciences [q-bio]/Immunology, [SDV.MHEP.CHI] Life Sciences [q-bio]/Human health and pathology/Surgery, [SDV]Life Sciences [q-bio], medicine.medical_treatment, Critical Illness, Medizin, MEDLINE, Delphi method, [SDV.MHEP.CHI]Life Sciences [q-bio]/Human health and pathology/Surgery, 030230 surgery, Liver transplantation, Severity of Illness Index, 03 medical and health sciences, 0302 clinical medicine, Multidisciplinary approach, Intensive care, Anesthesiology, Internal medicine, medicine, Humans, Intensive care medicine, Transplantation, Critically ill, business.industry, Graft Survival, Hepatology, Transplantation d'organes, 3. Good health, Liver Transplantation, [SDV.IMM]Life Sciences [q-bio]/Immunology, 030211 gastroenterology & hepatology, business
Abstract: BACKGROUND: Critically ill cirrhotic patients are increasingly transplanted, but there is no consensus about futile liver transplantation (LT). Therefore, the decision to delay or deny LT is often extensively debated. These debates arise from different opinions of futility among transplant team members. This study aims to achieve a multinational and multidisciplinary consensus on the definition of futility in LT and to develop well-articulated criteria for not proceeding with LT due to futility. METHODS: Thirty-five international experts from anesthesiology/intensive care, hepatology, and transplant surgery were surveyed using the Delphi method. More than 70% of similar answers to a question were necessary to define agreement. RESULTS: The panel recommended patient and graft survival at 1 year after LT to define futility. Severe frailty and persistent fever or 1 μg/kg per minute and a serum lactate level >9 mmol/L. CONCLUSIONS: Our expert panel provides a consensus on the definition of futile LT and on specific criteria for postponing or denying LT. A framework that may facilitate the decision if a patient is too sick for transplant is presented., SCOPUS: ar.j, info:eu-repo/semantics/published
Published: 2021

32. Unavoidable shear from quantum fluctuations in contracting cosmologies

Author: Vincent Vennin, Julien Grain, Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)
Subjects: High Energy Physics - Theory, cosmological model, Cosmology and Nongalactic Astrophysics (astro-ph.CO), Physics and Astronomy (miscellaneous), Planck mass, FOS: Physical sciences, lcsh:Astrophysics, General Relativity and Quantum Cosmology (gr-qc), field theory, 01 natural sciences, General Relativity and Quantum Cosmology, fluctuation: quantum, 0103 physical sciences, lcsh:QB460-466, energy: density, physics of the early universe, lcsh:Nuclear and particle physics. Atomic energy. Radioactivity, inflation, 010306 general physics, inflation: stochastic, Engineering (miscellaneous), Scale factor (cosmology), Quantum fluctuation, equation of state, Physics, Inflation (cosmology), 010308 nuclear & particles physics, Equation of state (cosmology), [PHYS.HTHE]Physics [physics]/High Energy Physics - Theory [hep-th], Space time, scale: Planck, stability, back reaction, boundary condition, quantum field theory on curved space, field theory: scalar, Classical mechanics, High Energy Physics - Theory (hep-th), space-time, bounce, [PHYS.GRQC]Physics [physics]/General Relativity and Quantum Cosmology [gr-qc], lcsh:QC770-798, Back-reaction, Scalar field, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: Contracting cosmologies are known to be flawed with a shear instability, where the contribution from the anisotropic stress to the overall energy density grows as $a^{-6}$, with $a$ the scale factor. Classically, whether or not this contribution becomes important before the bounce depends on its initial value, which can always be sufficiently fine tuned to make it irrelevant. However, vacuum quantum fluctuations inevitably provide a non-vanishing source of anisotropic stress. In this work, we compute the minimum amount of shear that is obtained if one assumes that it vanishes initially, but lets quantum fluctuations build it up. In practice, we consider a massless test scalar field, and describe its quantum fluctuations by means of the stochastic "inflation" (though here applied to a contracting phase) formalism. We find that, if the equation-of-state parameter of the contraction satisfies $w>-1/9$, regardless of when the contracting phase is initiated, the time at which the shear becomes sizeable is always when the Hubble scale approaches the Planck mass (which is also where the bounce is expected to take place). However, if $w, Comment: matches the published version in EPJC
Published: 2021

33. Invariant Measure for Stochastic Schrödinger Equations

Author: Martin Fraas, Yan Pautrat, Clément Pellegrini, Tristan Benoist, Institut de Mathématiques de Toulouse UMR5219 (IMT), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Virginia Tech [Blacksburg], Laboratoire de Mathématiques d'Orsay (LM-Orsay), Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11), ANR-11-LABX-0040,CIMI,Centre International de Mathématiques et d'Informatique (de Toulouse)(2011), ANR-14-CE25-0003,StoQ,Méthodes Stochastiques en Mécanique Quantique(2014), ANR-17-CE40-0006,NONSTOPS,Systèmes stochastiques et ouverts hors équilibre(2017), Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), and Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Quantum Physics, Nuclear and High Energy Physics, [PHYS.MPHY]Physics [physics]/Mathematical Physics [math-ph], 010102 general mathematics, Ergodicity, Time evolution, Markov process, Statistical and Nonlinear Physics, 16. Peace & justice, 01 natural sciences, Schrödinger equation, symbols.namesake, 0103 physical sciences, Quantum system, symbols, Applied mathematics, 010307 mathematical physics, Invariant measure, 0101 mathematics, Invariant (mathematics), Quantum, Mathematics - Probability, Mathematical Physics, Mathematics
Abstract: Quantum trajectories are Markov processes that describe the time-evolution of a quantum system undergoing continuous indirect measurement. Mathematically, they are defined as solutions of the so-called "Stochastic Schr\"odinger Equations", which are nonlinear stochastic differential equations driven by Poisson and Wiener processes. This paper is devoted to the study of the invariant measures of quantum trajectories. Particularly, we prove that the invariant measure is unique under an ergodicity condition on the mean time evolution, and a "purification" condition on the generator of the evolution. We further show that quantum trajectories converge in law exponentially fast towards this invariant measure. We illustrate our results with examples where we can derive explicit expressions for the invariant measure., Comment: As accepted in Ann. Henri Poincar\'e
Published: 2021

34. A Gravitational-wave Measurement of the Hubble Constant Following the Second Observing Run of Advanced LIGO and Virgo

Author: G. Pagliaroli, Kevin Barkett, Denis Martynov, Marco Bazzan, C. Ingram, L. Pinard, Nicolas Sanchis-Gual, I. Belahcene, A. K. Y. Li, Archana Pai, F. Paoletti, P. Ruggi, G. Vajente, S. M. Gaebel, C. Kr mer, K. W. Chung, I. Dorrington, I. Di Palma, A. Mullavey, T. J. N. Nelson, Filip Morawski, Xiaohui Fan, Richard O'Shaughnessy, B. Barr, B. D. Lackey, G. Eddolls, A. Cumming, P. Grassia, Kipp Cannon, F. Di Renzo, M. Steinke, Francesco Pannarale, Soichiro Morisaki, D. Ugolini, P. Clearwater, M. Haney, T. A. Callister, Zhihui Du, G. Ciani, Alessandro Bertolini, Olivier Minazzoli, M. Razzano, Mairi Sakellariadou, G. Pillant, S. H. R. Yuen, O. de Varona, A. L. Stuver, R. De Rosa, I. Nardecchia, M. Kasprzack, J. Baird, Frances Hellman, M. B. Shaner, Manel Molina-Ruiz, S. B. Coughlin, Jessica Steinlechner, A. Neunzert, M. Heurs, Reed Essick, S. Kandhasamy, B. Sorazu, A. Kutynia, Andrea Chincarini, T. Z. Summerscales, Tenglin Li, Robert J. McCarthy, Linqing Wen, D. Meacher, Leo Tsukada, E. Z. Hamilton, A. Parida, S. S. Eikenberry, E. Genin, D. Estevez, W. Katzman, B. Grace, S. M. Aronson, M. Llorens-Monteagudo, M. Nery, Ryan Lynch, Ettore Majorana, D. M. Wilken, A. Rocchi, B. Goncharov, R. Birney, P. Ehrens, Paul M. Ricker, E. J. Fauchon-Jones, M. Lormand, William Parker, D. J. Stops, J. S. H. Lee, Felix Wellmann, Shreya Anand, D. Huet, S. H. Huttner, Z. Tornasi, Andrew Melatos, M. Lorenzini, M. Bitossi, J.-G. Ducoin, J. Neilson, G. Bergmann, K. Wette, John J. Oh, Timothy Evans, M. G. Benjamin, E. Payne, Rory Smith, C. Adams, R. M. Blair, D. Sigg, S. W. Ballmer, Z. Yang, D. M. Shoemaker, Michelle E. Walker, J. Eichholz, G. Moreno, H. Inchauspe, J. Liu, A. Pasqualetti, M. Tse, D. M. Macleod, B. L. Swinkels, J. Warner, R. Passaquieti, C. Rajan, O. Durante, N. Krupinski, F. Martelli, Karan Jani, Jade Powell, V. Mangano, H. K. Gulati, David H. Reitze, Rahul Kashyap, C. McIsaac, Nergis Mavalvala, A. K. Lenon, S. Mastrogiovanni, P. A. Altin, Piotr Jaranowski, Florent Robinet, J. Zhang, F. Baldaccini, L. F. Ortega, Jerome Degallaix, R. C. Walet, V. P. Mitrofanov, Rosa Poggiani, V. Frey, T. Sadecki, V. Tiwari, Yann Bouffanais, A. C. Green, C. Casentini, R. Shink, E. Goetz, F. Magaña-Sandoval, J. McIver, Sebastian Khan, B. C. Barish, J. H. Briggs, Mark Hannam, L. Rei, Gijs Nelemans, Tanja Hinderer, Alejandro Torres-Forné, A. K. Zadrożny, P.H. Nguyen, V. Boschi, E. J. Son, M. van Beuzekom, S. Grunewald, R. Prasanna, A. Ain, Shubhanshu Tiwari, G. A. Prodi, R. DeSalvo, V. Kondrashov, F. Frasconi, A. K. Mehta, E. D. Hall, S. Farinon, E. Mejuto Villa, D. Barker, A. Samajdar, Jolien D. E. Creighton, A. Pele, D. Singh, Arunava Mukherjee, Fausto Acernese, J. C. Barayoga, B. F. Neil, R. Flaminio, Richard J. Abbott, D. W. Yeeles, Hartmut Grote, D. C. Vander-Hyde, P. Puppo, W. Del Pozzo, Y. Minenkov, P. Bacon, P. F. Cohadon, H. Heitmann, A. Strunk, N. Kijbunchoo, Piero Rettegno, K. A. Santiago, P. J. Sutton, M. Cieślar, Maria Ilaria Del Principe, P. Raffai, J. C. Bayley, H. Wittel, M. Deenadayalan, G. H. Ogin, T. J. Shaffer, Marcus E. Lower, L. Glover, G. Losurdo, S. Biscoveanu, O. V. Palashov, Sean T. McWilliams, F. Piergiovanni, Chang-Hwan Lee, D. E. Cohen, M. Agathos, J. H. Romie, S. Sitmukhambetov, G. Kuehn, K. Merfeld, M. Ar ne, M. Phelps, Archisman Ghosh, R. G. Ormiston, Andrew Matas, A. Chiummo, K. Holt, M. Mantovani, E. A. Huerta, A. Ramos-Buades, S. L. Danilishin, Tristan Briant, R. K. Lanza, P. Dupej, Sheelu Abraham, Eric B. Flynn, J. Betzwieser, Antoine Heidmann, J. Hanks, A. Sur, H. Overmier, R. Goetz, Tarun Souradeep, J. P. Zendri, L. Sun, C. De Rossi, D. Buskulic, Odylio D. Aguiar, James Healy, P. Brockill, Luca Gammaitoni, R. Fittipaldi, C. Horst, Alberto Vecchio, F. Cipriano, Michael Thomas, R. Tenorio, N. A. Holland, D. Sellers, P. Popolizio, Koji Arai, F. J. Raab, Devon S. Johnson, N. Mukund, L. R. Cominsky, Neil J. Cornish, Colm Talbot, Andreas Freise, M. Davier, Sebastiano Bernuzzi, O. Halim, S. Koley, M. Brinkmann, C. Affeldt, S. Appert, Y. Setyawati, E. J. Sanchez, Nicholas Demos, J. D. Lough, D. Pascucci, H. S. Chen, L. E. H. Datrier, M. Bawaj, R. L. Savage, A. S. Bell, M. Laxen, Anchal Gupta, J. Meidam, M. Gosselin, Riccardo Sturani, M. K. M. Bader, O. Chaibi, Wolfango Plastino, R. Taylor, C. L. Romel, Giovanni Carapella, P. Shawhan, I. Ferrante, Soma Mukherjee, Charalampos Markakis, G. Mo, J. K. Blackburn, C. J. Richardson, F. L. Linde, E. Chassande-Mottin, Sylvain Marsat, Sheila Rowan, B. Gateley, Howard Pan, Aaron Buikema, R. Kirchhoff, B. L. Pearlstone, V. Fafone, Paul D. Lasky, R. K. Hasskew, Jordan Camp, D. Tao, M. Muratore, M. C. Heintze, D. Sentenac, F. Carbognani, Patrick Brady, P. Fulda, J. M. Fishner, Will M. Farr, M. Montani, Nancy Aggarwal, R. Gustafson, A. Grimaldi, J. W. Westhouse, Matthew Pitkin, F. Lin, Tania Regimbau, Serena Vinciguerra, F. Garufi, Chandra Kant Mishra, Joseph D. Romano, R. Bhandare, R. Pedurand, Benno Willke, C. C. Wipf, V. Pierro, M. J. Cowart, I. Dave, Lee McCuller, O. J. Piccinni, Takuya Tsutsui, T. D. Abbott, Zoheyr Doctor, M. Fletcher, B. Hughey, K. W. Tsang, P. J. Veitch, M. Rakhmanov, Surendra Nadh Somala, Gregorio Carullo, R. Xu, C. Buy, M. Oliver, Kazuhiro Agatsuma, T. J. Hansen, N. Bode, Christopher P. L. Berry, T. Harder, Rico K. L. Lo, P. Charlton, Kejia Lee, Patrick Das Gupta, S. E. Barclay, J. L. Willis, M. Eisenmann, Ofek Birnholtz, John A. Clark, Ben Farr, W. S. Kim, Christophe Collette, L. Kuo, H. Yamamoto, J. C. Driggers, A. Schönbeck, B. Rajbhandari, Daniel Wysocki, J. Prasad, A. J. Pedersen, S. B. Anderson, Tim Dietrich, M. Pürrer, S. Kwang, Frank Ohme, Vicky Kalogera, K. Rose, M. Tonelli, E. Katsavounidis, Xiuling Li, R. Gray, Patrick Godwin, M. C. Araya, Srishti Tiwari, S. Frasca, Jonathan Richardson, Tyson Littenberg, Kai Staats, L. Conti, M. Chaturvedi, Yu Huang, Geert Raaijmakers, F. Y. Khalili, R. P. Fisher, A. Allocca, D. I. Jones, Guoying Zhao, Kendall Ackley, R. K. Nayak, S. Raja, H. Y. Chia, Sascha Husa, S. E. Strigin, S. Mitra, M. Granata, H. J. Bulten, Minchuan Zhou, Shao-Jiang Wang, T. D. Creighton, S. E. Gossan, Dániel Barta, G. Venugopalan, Karl Gill, V. Srivastava, M. Fays, S. Barnum, S. C. Tait, K. Shukla, Zifan Zhou, I. A. Bilenko, L. Haegel, D.B. DeBra, David J. Ottaway, C. J. Perez, Matthew Evans, B. D. O'Brien, Marek Szczepanczyk, C. Bradaschia, M. Standke, Deep Jariwala, C. Cahillane, Otto A. Hannuksela, C. Gray, H. Estelles, W. A. Campbell, H. Radkins, A. Bozzi, N. N. Janthalur, L. Wallace, A. Królak, R. Frey, E. A. Muñiz, B. Sassolas, S. Brunett, Monica Colpi, Albino Perego, A. Bisht, M. Boer, J. B. Kanner, Andrew Lundgren, S. Xiao, J. V. Vanheijningen, D. Fiorucci, Zachariah B. Etienne, D. Moraru, E. Floden, Jennifer Watchi, A. K. Prajapati, Gianpietro Cagnoli, A. R. Wade, A. Di Lieto, S. J. Chamberlin, M. Vasúth, C. M. Mow-Lowry, Sergey P. Vyatchanin, Jonathan Cripe, V. Bossilkov, A. Paoli, Ik Siong Heng, A. Rüdiger, R. Inta, Steven Bloemen, Jonathan R. Gair, S. Klimenko, Eric Howell, E. Cesarini, S. Márka, N. Sennett, Stephen Fairhurst, Carl Blair, V. Fiumara, M. F. Carney, C. Lazzaro, Patricia Schmidt, Ajay Kumar, Y. K. Lecoeuche, M. J. Yap, C. Whittle, Bala R. Iyer, Stefan Grimm, D. B. Tanner, Kevin M. Ryan, S. McCormick, C. Difronzo, G. M. Harry, C. Palomba, S. Ascenzi, A. L. Miller, K. Venkateswara, L. Aiello, R. Green, Giuseppe Intini, Kenneth A. Strain, Jimin George, M. Sieniawska, Gregory Ashton, K. Chakravarti, G. Valdes, Ken K. Y. Ng, E. E. Cowan, B. D'Angelo, Hongyu Shen, D. C. Coyne, T. Dal Canton, J. Casanueva Diaz, P. Couvares, H. Fong, G. Greco, J. Zweizig, M. S. Shahriar, M. Korobko, J. Brooks, K. Siellez, Shiuh Chao, C. Périgois, P. Astone, Carlos O. Lousto, T. Hardwick, D. Steinmeyer, David Coward, A. Miani, R. Cotesta, Rakesh Kumar, F. Travasso, Yuri Levin, T. P. Downes, Gor Oganesyan, A. F. Brooks, P. J. Quinonez, Fabio Marchesoni, P. Hello, J. Gniesmer, Kyungmin Kim, Debarati Chatterjee, A. Trovato, B. O'Reilly, P. Gruning, Sheon Chua, R. Bonnand, C. North, Mariana Fazio, F. Vetrano, Samuele Cortese, Thomas Dent, P. Corban, S. J. Cooper, S. Leavey, Hai-Ping Cheng, A. Iess, M. Pedraza, M. Chan, Francesco Chiadini, Michał Bejger, Charlie Hoy, P. Schale, J. Jiang, J. Hennig, J. Junker, C. Van Den Broeck, E. Sowell, V. Gayathri, V. Hui, S. Walsh, Miriam Cabero, Alexander C. Jenkins, A. Markowitz, Robert Stone, M. Was, M. M. Hanke, G. Cho, James Whelan, P. Ajith, P. Booker, A. Perreca, G. Gemme, M. Drago, M. Di Giovanni, A. Malik, S. Gaudio, G. Dálya, T. Prestegard, J. Scott, L. K. Nuttall, A. W. Jones, Alessandro Nagar, R. De Pietri, Rocco Romano, M. Kinley-Hanlon, Lindsay DeMarchi, K. A. Thorne, E. L. Merilh, S. E. Dwyer, David Keitel, L. Matone, Mandar Patil, Guenakh Mitselmakher, B. A. Boom, A. M. Sergeev, Karsten Danzmann, A. R. Williamson, H. Vocca, Mario Spera, Peter Aufmuth, Andrea H. Tapia, Hua Wang, F. Cavalier, A. 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Zelenova, Riccardo Bassiri, Sebastian Steinlechner, C. A. Rose, X. Liu, Torrey Cullen, Magnus Manske, Bernard F. Whiting, Jesper Munch, Fabien Kéfélian, J. H. Hough, P. W. F. Forsyth, S. R. Thondapu, Chris A. Collins, Achamveedu Gopakumar, M. De Laurentis, M. Bischi, M. C. Milovich-Goff, J. L. Wright, J. R. Palamos, P. T. Baker, Carl-Johan Haster, Alessandra Corsi, D. Laghi, S. D'Antonio, E. Maros, P. B. Covas, L. Rolland, N. Letendre, B. D. Cheeseboro, B. Lantz, David Blair, P. J. Easter, K. Mogushi, Michele Zanolin, I. Magaña Hernandez, T. J. Massinger, Kiran Prasai, M. Khursheed, L. Naticchioni, D. Töyr, G. Vedovato, D. B. Kozak, F. Brighenti, Aniello Grado, D. Stocks, C. Vorvick, T. Vo, E. J. Daw, Salvatore Vitale, P. J. King, G. D. Hammond, K. H. Lai, Aaron Viets, Javed Rana, Abhirup Ghosh, G. Kang, A. L. Urban, Maurizio Canepa, J. Feicht, Satya Mohapatra, Antonio Marquina, L. Errico, T. A. Ferreira, K. D. Giardina, E. M. Santos, Nikhil Sarin, Martin Obergaulinger, M. Mondin, F. Marion, T. Huynh-Dinh, P. Weßels, Joey Shapiro Key, J. R. Sanders, C. F. Da Silva Costa, J. K. Wofford, Vuk Mandic, Chunglee Kim, M. A. Page, J. S. Kissel, H. Cao, D. J. Vine, R. M. S. Schofield, Fabrizio Barone, M. T. Hübner, N. Man, D. Lumaca, Benjamin J. Owen, J. F. J. van den Brand, J. S. Lange, M. A. Okada, E. Cuoco, Binlei Ding, S. Sunil, M. Tacca, Marta Colleoni, Bruno Giacomazzo, A. Gupta, Martin Hendry, Cecilio García-Quirós, J. A. Giaime, M. C. Tringali, K. Haughian, S. Hochheim, N. A. Robertson, D. Corre, Y. M. Kim, B. R. Hall, Maher Yazback, J. G. Bartlett, Márton Tápai, Marc Favata, Matteo Breschi, Fabrizio Bobba, Roger Jones, V. J. Roma, M. C. Díaz, Liam Cunningham, K. Mason, L. Trozzo, Antonios Kontos, S. A. Bilgili, E. C. Ferreira, Albert Lazzarini, A. P. Spencer, Sanjeev Dhurandhar, Jonathan Blackman, D. D. Brown, Anthony A. Amato, N. van Bakel, K. Toland, D. J. Hofman, A. Dmitriev, Samaya Nissanke, Y. Boetzel, S. Meshkov, Seog Oh, M. A. Bizouard, B. K. Berger, N. V. Krishnendu, Alec Mishkin, R. Cavalieri, José A. Font, C. C. Yancey, A. K. Srivastava, A. E. Pace, W. G. Anderson, N. Singh, Subroto Mukherjee, G. Cella, K. Rao, C. Fee, Maya Fishbach, Silvia Corezzi, S. Bae, E. Coccia, S. Katsanevas, M. E. Zucker, B. A. Weaver, J. G. Rollins, L.-W. Wei, Madeline Wade, P. Leaci, G. Rutins, J. D. Jones, T. C. Pechsiri, Graham Woan, Robert L. Byer, Stuart Reid, A. Masserot, K. Kawabe, S. M. Aston, K. Ueno, A. Basti, Ryan N. Lang, Podila Satya Venkata Narasimha Sharma, B. P. Abbott, E. K. Gustafson, Q. Chu, Xin Chen, R. M. Martin, David A. Nichols, A. M. Holgado, K. G. Arun, S. V. Angelova, C. Nguyen, S. Vass, J.-P. Coulon, M. Fitz-Axen, F. J. Hayes, Pablo Cerdá-Durán, Vivien Raymond, Jacob Scheuer, Michael W. Coughlin, I. Khan, G. Pagano, V. Avendano, P. Oppermann, F. Messina, R. Coyne, Fabrice Matichard, E. K. Wessel, E. A. Chase, Z. Frei, Bernard F. Schutz, Daniel E. Holz, B. J. J. Slagmolen, V. Sequino, L. E. Wade, S. Caride, David A. 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Ponrathnam, Chunnong Zhao, D. Moffa, David H. Shoemaker, S. Karki, J. J. McCann, T. J. Slaven-Blair, S. ShyamSundar, C. Stachie, S. P. Stevenson, Sebastien Biscans, V. Kringel, R. Tso, S. A. Nichols, M. Kovalam, L. Mereni, D. Passuello, Patrick M. Koch, S. Antier, A. Cirone, S. Banagiri, T. L. Lam, Hyun Lee, Tomasz Bulik, J. Calderón Bustillo, Alessandro Longo, Richard J. Oram, François Bondu, Edward K. Porter, Stefan Hild, Y. Ma, A. Brillet, D. Rose, M. Vardaro, Valérie Martinez, A. Avila-Alvarez, Cesare Barbieri, Walter Winkler, A. S. Markosyan, Harald Lück, L. Nevin, D. Verkindt, M. Cho, J. Cao, G. Gaur, S. C. McGuire, J. F. Read, S. Di Pace, K. Haris, I. Maksimovic, R. L. Ward, G. Hemming, F. Badaracco, C. Messenger, S. M. Koehlenbeck, N. Leroy, B. Bécsy, Des Gibson, Vivishek Sudhir, E. Schreiber, L. Terkowski, Leo Singer, Ryan Magee, Nandita Khetan, Laura Cadonati, D. A. Steer, A. Gennai, L. Kleybolte, Harald P. Pfeiffer, M. Rizzo, I. W. Martin, David E. McClelland, Daniel R. 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Rosińska, The LIGO Scientific Collaboration, The Virgo Collaboration, Science and Technology Facilities Council (UK), Australian Research Council, Istituto Nazionale di Fisica Nucleare, Council of Science and Technology UP (India), Ministerio de Ciencia, Innovación y Universidades (España), Govern de les Illes Balears, Generalitat Valenciana, National Science Centre (Poland), Russian Foundation for Basic Research, Swiss National Science Foundation, European Commission, Royal Society (UK), Hungarian Scientific Research Fund, National Research Foundation of Korea, Canadian Institute for Advanced Research, Ministry of Science and Technology (Taiwan), Kavli Institute for Particle Astrophysics and Cosmology, Apollo - University of Cambridge Repository, Abbott, B. P., Abbott, R., Abbott, T. D., Abraham, S., Acernese, F., Ackley, K., Adams, C., Adhikari, R. X., Adya, V. B., Affeldt, C., Agathos, M., Agatsuma, K., Aggarwal, N., Aguiar, O. 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L., Bersanetti, D., Bertolini, A., Betzwieser, J., Bhandare, R., Bidler, J., Biggs, E., Bilenko, I. A., Bilgili, S. A., Billingsley, G., Birney, R., Birnholtz, O., Biscans, S., Bischi, M., Biscoveanu, S., Bisht, A., Bitossi, M., Bizouard, M. A., Blackburn, J. K., Blackman, J., Blair, C. D., Blair, D. G., Blair, R. M., Bloemen, S., Bobba, F., Bode, N., Boer, M., Boetzel, Y., Bogaert, G., Bondu, F., Bonnand, R., Booker, P., Boom, B. A., Bork, R., Boschi, V., Bose, S., Bossilkov, V., Bosveld, J., Bouffanais, Y., Bozzi, A., Bradaschia, C., Brady, P. R., Bramley, A., Branchesi, M., Brau, J. E., Breschi, M., Briant, T., Briggs, J. H., Brighenti, F., Brillet, A., Brinkmann, M., Brockill, P., Brooks, A. F., Brooks, J., Brown, D. D., Brunett, S., Buikema, A., Bulik, T., Bulten, H. J., Buonanno, A., Buskulic, D., Buy, C., Byer, R. L., Cabero, M., Cadonati, L., Cagnoli, G., Cahillane, C., Bustillo, J. C., Callister, T. A., Calloni, E., Camp, J. B., Campbell, W. A., Canepa, M., Cannon, K. C., Cao, H., Cao, J., Carapella, G., Carbognani, F., Caride, S., Carney, M. F., Carullo, G., Diaz, J. C., Casentini, C., Caudill, S., Cavagli, M., Cavalier, F., Cavalieri, R., Cella, G., Cerda-Duran, P., Cesarini, E., Chaibi, O., Chakravarti, K., Chamberlin, S. J., Chan, M., Chao, S., Charlton, P., Chase, E. A., Chassande-Mottin, E., Chatterjee, D., Chaturvedi, M., Cheeseboro, B. D., Chen, H. Y., Chen, X., Chen, Y., Cheng, H. -P., Cheong, C. K., Chia, H. Y., Chiadini, F., Chincarini, A., Chiummo, A., Cho, G., Cho, H. S., Cho, M., Christensen, N., Chu, Q., Chua, S., Chung, K. W., Chung, S., Ciani, G., Cieslar, M., Ciobanu, A. A., Ciolfi, R., Cipriano, F., Cirone, A., Clara, F., Clark, J. A., Clearwater, P., Cleva, F., Coccia, E., Cohadon, P. -F., Cohen, D., Colleoni, M., Collette, C. G., Collins, C., Colpi, M., Cominsky, L. R., Constancio, M., Conti, L., Cooper, S. J., Corban, P., Corbitt, T. R., Cordero-Carrion, I., Corezzi, S., Corley, K. 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R., Hall, E. D., Hamilton, E. Z., Hammond, G., Haney, M., Hanke, M. M., Hanks, J., Hanna, C., Hannam, M. D., Hannuksela, O. A., Hansen, T. J., Hanson, J., Harder, T., Hardwick, T., Haris, K., Harms, J., Harry, G. M., Harry, I. W., Hasskew, R. K., Haster, C. J., Haughian, K., Hayes, F. J., Healy, J., Heidmann, A., Heintze, M. C., Heitmann, H., Hellman, F., Hello, P., Hemming, G., Hendry, M., Heng, I. S., Hennig, J., Heurs, M., Hild, S., Hinderer, T., Hochheim, S., Hofman, D., Holgado, A. M., Holland, N. A., Holt, K., Holz, D. E., Hopkins, P., Horst, C., Hough, J., Howell, E. J., Hoy, C. G., Huang, Y., Hubner, M. T., Huerta, E. A., Huet, D., Hughey, B., Hui, V., Husa, S., Huttner, S. H., Huynh-Dinh, T., Idzkowski, B., Iess, A., Inchauspe, H., Ingram, C., Inta, R., Intini, G., Irwin, B., Isa, H. N., Isac, J. -M., Isi, M., Iyer, B. R., Jacqmin, T., Jadhav, S. J., Jani, K., Janthalur, N. N., Jaranowski, P., Jariwala, D., Jenkins, A. C., Jiang, J., Johnson, D. S., Jones, A. W., Jones, D. I., Jones, J. D., Jones, R., Jonker, R. J. G., Ju, L., Junker, J., Kalaghatgi, C. V., Kalogera, V., Kamai, B., Kandhasamy, S., Kang, G., Kanner, J. B., Kapadia, S. J., Karathanasis, C., Karki, S., Kashyap, R., Kasprzack, M., Katsanevas, S., Katsavounidis, E., Katzman, W., Kaufer, S., Kawabe, K., Keerthana, N. V., Kefelian, F., Keitel, D., Kennedy, R., Key, J. S., Khalili, F. Y., Khan, I., Khan, S., Khazanov, E. A., Khetan, N., Khursheed, M., Kijbunchoo, N., Kim, C., Kim, J. C., Kim, K., Kim, W., Kim, W. S., Kim, Y. -M., Kimball, C., King, P. J., Kinley-Hanlon, M., Kirchhoff, R., Kissel, J. S., Kleybolte, L., Klika, J. H., Klimenko, S., Knowles, T. D., Koch, P., Koehlenbeck, S. M., Koekoek, G., Koley, S., Kondrashov, V., Kontos, A., Koper, N., Korobko, M., Korth, W. Z., Kovalam, M., Kozak, D. B., Kr mer, C., Kringel, V., Krishnendu, N., Krolak, A., Krupinski, N., Kuehn, G., Kumar, A., Kumar, P., Kumar, R., Kuo, L., Kutynia, A., Kwang, S., Lackey, B. D., Laghi, D., Lai, K. H., Lam, T. 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M., Xiao, S., Xu, R., Yamamoto, H., Yancey, C. C., Yang, L., Yang, Y., Yang, Z., Yap, M. J., Yazback, M., Yeeles, D. W., Yu, H., Yuen, S. H. R., Zadrozny, A. K., Zadrozny, A., Zanolin, M., Zelenova, T., Zendri, J. -P., Zevin, M., Zhang, J., Zhang, L., Zhang, T., Zhao, C., Zhao, G., Zhou, M., Zhou, Z., Zhu, X. J., Zimmerman, A. B., Zucker, M. E., Zweizig, J., Van Swinderen Institute for Particle Physics and G, Abbott, B, Abbott, R, Abbott, T, Abraham, S, Acernese, F, Ackley, K, Adams, C, Adhikari, R, Adya, V, Affeldt, C, Agathos, M, Agatsuma, K, Aggarwal, N, Aguiar, O, Aiello, L, Ain, A, Ajith, P, Allen, G, Allocca, A, Aloy, M, Altin, P, Amato, A, Anand, S, Ananyeva, A, Anderson, S, Anderson, W, Angelova, S, Antier, S, Appert, S, Arai, K, Araya, M, Areeda, J, Ar ne, M, Arnaud, N, Aronson, S, Arun, K, Ascenzi, S, Ashton, G, Aston, S, Astone, P, Aubin, F, Aufmuth, P, Aultoneal, K, Austin, C, Avendano, V, Avila-Alvarez, A, Babak, S, Bacon, P, Badaracco, F, Bader, M, Bae, S, Baird, J, Baker, P, Baldaccini, F, Ballardin, G, Ballmer, S, Bals, A, Banagiri, S, Barayoga, J, Barbieri, C, Barclay, S, Barish, B, Barker, D, Barkett, K, Barnum, S, Barone, F, Barr, B, Barsotti, L, Barsuglia, M, Barta, D, Bartlett, J, Bartos, I, Bassiri, R, Basti, A, Bawaj, M, Bayley, J, Bazzan, M, Becsy, B, Bejger, M, Belahcene, I, Bell, A, Beniwal, D, Benjamin, M, Berger, B, Bergmann, G, Bernuzzi, S, Berry, C, Bersanetti, D, Bertolini, A, Betzwieser, J, Bhandare, R, Bidler, J, Biggs, E, Bilenko, I, Bilgili, S, Billingsley, G, Birney, R, Birnholtz, O, Biscans, S, Bischi, M, Biscoveanu, S, Bisht, A, Bitossi, M, Bizouard, M, Blackburn, J, Blackman, J, Blair, C, Blair, D, Blair, R, Bloemen, S, Bobba, F, Bode, N, Boer, M, Boetzel, Y, Bogaert, G, Bondu, F, Bonnand, R, Booker, P, Boom, B, Bork, R, Boschi, V, Bose, S, Bossilkov, V, Bosveld, J, Bouffanais, Y, Bozzi, A, Bradaschia, C, Brady, P, Bramley, A, Branchesi, M, Brau, J, Breschi, M, Briant, T, Briggs, J, Brighenti, F, Brillet, A, Brinkmann, M, Brockill, P, Brooks, A, Brooks, J, Brown, D, Brunett, S, Buikema, A, Bulik, T, Bulten, H, Buonanno, A, Buskulic, D, Buy, C, Byer, R, Cabero, M, Cadonati, L, Cagnoli, G, Cahillane, C, Bustillo, J, Callister, T, Calloni, E, Camp, J, Campbell, W, Canepa, M, Cannon, K, Cao, H, Cao, J, Carapella, G, Carbognani, F, Caride, S, Carney, M, Carullo, G, Diaz, J, Casentini, C, Caudill, S, Cavagli, M, Cavalier, F, Cavalieri, R, Cella, G, Cerda-Duran, P, Cesarini, E, Chaibi, O, Chakravarti, K, Chamberlin, S, Chan, M, Chao, S, Charlton, P, Chase, E, Chassande-Mottin, E, Chatterjee, D, Chaturvedi, M, Cheeseboro, B, Chen, H, Chen, X, Chen, Y, Cheng, H, Cheong, C, Chia, H, Chiadini, F, Chincarini, A, Chiummo, A, Cho, G, Cho, H, Cho, M, Christensen, N, Chu, Q, Chua, S, Chung, K, Chung, S, Ciani, G, Cieslar, M, Ciobanu, A, Ciolfi, R, Cipriano, F, Cirone, A, Clara, F, Clark, J, Clearwater, P, Cleva, F, Coccia, E, Cohadon, P, Cohen, D, Colleoni, M, Collette, C, Collins, C, Colpi, M, Cominsky, L, Constancio, M, Conti, L, Cooper, S, Corban, P, Corbitt, T, Cordero-Carrion, I, Corezzi, S, Corley, K, Cornish, N, Corre, D, Corsi, A, Cortese, S, Costa, C, Cotesta, R, Coughlin, M, Coughlin, S, Coulon, J, Countryman, S, Couvares, P, Covas, P, Cowan, E, Coward, D, Cowart, M, Coyne, D, Coyne, R, Creighton, J, Creighton, T, Cripe, J, Croquette, M, Crowder, S, Cullen, T, Cumming, A, Cunningham, L, Cuoco, E, Dal Canton, T, Dalya, G, D'Angelo, B, Danilishin, S, D'Antonio, S, Danzmann, K, Dasgupta, A, Da Silva Costa, C, Datrier, L, Dattilo, V, Dave, I, Davier, M, Davis, D, Daw, E, Debra, D, Deenadayalan, M, Degallaix, J, De Laurentis, M, Deleglise, S, Pozzo, W, Demarchi, L, Demos, N, Dent, T, De Pietri, R, De Rosa, R, De Rossi, C, Desalvo, R, De Varona, O, Dhurandhar, S, Diaz, M, Dietrich, T, Di Fiore, L, Difronzo, C, Di Giorgio, C, Di Giovanni, F, Di Giovanni, M, Di Girolamo, T, Di Lieto, A, Ding, B, Di Pace, S, Di Palma, I, Di Renzo, F, Divakarla, A, Dmitriev, A, Doctor, Z, Donovan, F, Dooley, K, Doravari, S, Dorrington, I, Downes, T, Drago, M, Driggers, J, Du, Z, Ducoin, J, Dupej, P, Durante, O, Dwyer, S, Easter, P, Eddolls, G, Edo, T, Effler, A, Ehrens, P, Eichholz, J, Eikenberry, S, Eisenmann, M, Eisenstein, R, Errico, L, Essick, R, Estelles, H, Estevez, D, Etienne, Z, Etzel, T, Evans, M, Evans, T, Fafone, V, Fairhurst, S, Fan, X, Farinon, S, Farr, B, Farr, W, Fauchon-Jones, E, Favata, M, Fays, M, Fazio, M, Fee, C, Feicht, J, Fejer, M, Feng, F, Fernandez-Galiana, A, Ferrante, I, Ferreira, E, Ferreira, T, Fidecaro, F, Fiori, I, Fiorucci, D, Fishbach, M, Fisher, R, Fishner, J, Fittipaldi, R, Fitz-Axen, M, Fiumara, V, Flaminio, R, Fletcher, M, Floden, E, Flynn, E, Fong, H, Font, J, Forsyth, P, Fournier, J, Vivanco, F, Frasca, S, Frasconi, F, Frei, Z, Freise, A, Frey, R, Frey, V, Fritschel, P, Frolov, V, Fronz, G, Fulda, P, Fyffe, M, Gabbard, H, Gadre, B, Gaebel, S, Gair, J, Gammaitoni, L, Gaonkar, S, Garcia-Quiros, C, Garufi, F, Gateley, B, Gaudio, S, Gaur, G, Gayathri, V, Gemme, G, Genin, E, Gennai, A, George, D, George, J, Gergely, L, Ghonge, S, Ghosh, A, Ghosh, S, Giacomazzo, B, Giaime, J, Giardina, K, Gibson, D, Gill, K, Glover, L, Gniesmer, J, Godwin, P, Goetz, E, Goetz, R, Goncharov, B, Gonzalez, G, Gonzalez Castro, J, Gopakumar, A, Gossan, S, Gosselin, M, Gouaty, R, Grace, B, Grado, A, Granata, M, Grant, A, Gras, S, Grassia, P, Gray, C, Gray, R, Greco, G, Green, A, Green, R, Gretarsson, E, Grimaldi, A, Grimm, S, Groot, P, Grote, H, Grunewald, S, Gruning, P, Guidi, G, Gulati, H, Guo, Y, Gupta, A, Gupta, P, Gustafson, E, Gustafson, R, Haegel, L, Halim, O, Hall, B, Hall, E, Hamilton, E, Hammond, G, Haney, M, Hanke, M, Hanks, J, Hanna, C, Hannam, M, Hannuksela, O, Hansen, T, Hanson, J, Harder, T, Hardwick, T, Haris, K, Harms, J, Harry, G, Harry, I, Hasskew, R, Haster, C, Haughian, K, Hayes, F, Healy, J, Heidmann, A, Heintze, M, Heitmann, H, Hellman, F, Hello, P, Hemming, G, Hendry, M, Heng, I, Hennig, J, Heurs, M, Hild, S, Hinderer, T, Hochheim, S, Hofman, D, Holgado, A, Holland, N, Holt, K, Holz, D, Hopkins, P, Horst, C, Hough, J, Howell, E, Hoy, C, Huang, Y, Hubner, M, Huerta, E, Huet, D, Hughey, B, Hui, V, Husa, S, Huttner, S, Huynh-Dinh, T, Idzkowski, B, Iess, A, Inchauspe, H, Ingram, C, Inta, R, Intini, G, Irwin, B, Isa, H, Isac, J, Isi, M, Iyer, B, Jacqmin, T, Jadhav, S, Jani, K, Janthalur, N, Jaranowski, P, Jariwala, D, Jenkins, A, Jiang, J, Johnson, D, Jones, A, Jones, D, Jones, J, Jones, R, Jonker, R, Ju, L, Junker, J, Kalaghatgi, C, Kalogera, V, Kamai, B, Kandhasamy, S, Kang, G, Kanner, J, Kapadia, S, Karathanasis, C, Karki, S, Kashyap, R, Kasprzack, M, Katsanevas, S, Katsavounidis, E, Katzman, W, Kaufer, S, Kawabe, K, Keerthana, N, Kefelian, F, Keitel, D, Kennedy, R, Key, J, Khalili, F, Khan, I, Khan, S, Khazanov, E, Khetan, N, Khursheed, M, Kijbunchoo, N, Kim, C, Kim, J, Kim, K, Kim, W, Kim, Y, Kimball, C, King, P, Kinley-Hanlon, M, Kirchhoff, R, Kissel, J, Kleybolte, L, Klika, J, Klimenko, S, Knowles, T, Koch, P, Koehlenbeck, S, Koekoek, G, Koley, S, Kondrashov, V, Kontos, A, Koper, N, Korobko, M, Korth, W, Kovalam, M, Kozak, D, Kr mer, C, Kringel, V, Krishnendu, N, Krolak, A, Krupinski, N, Kuehn, G, Kumar, A, Kumar, P, Kumar, R, Kuo, L, Kutynia, A, Kwang, S, Lackey, B, Laghi, D, Lai, K, Lam, T, Landry, M, Lane, B, Lang, R, Lange, J, Lantz, B, Lanza, R, Lartaux-Vollard, A, Lasky, P, Laxen, M, Lazzarini, A, Lazzaro, C, Leaci, P, Leavey, S, Lecoeuche, Y, Lee, C, Lee, H, Lee, J, Lee, K, Lehmann, J, Lenon, A, Leroy, N, Letendre, N, Levin, Y, Li, A, Li, J, Li, K, Li, T, Li, X, Lin, F, Linde, F, Linker, S, Littenberg, T, Liu, J, Liu, X, Llorens-Monteagudo, M, Lo, R, London, L, Longo, A, Lorenzini, M, Loriette, V, Lormand, M, Losurdo, G, Lough, J, Lousto, C, Lovelace, G, Lower, M, Luck, H, Lumaca, D, Lundgren, A, Lynch, R, Ma, Y, Macas, R, Macfoy, S, Macinnis, M, Macleod, D, Macquet, A, Hernandez, I, Magana-Sandoval, F, Magee, R, Majorana, E, Maksimovic, I, Malik, A, Man, N, Mandic, V, Mangano, V, Mansell, G, Manske, M, Mantovani, M, Mapelli, M, Marchesoni, F, Marion, F, Marka, S, Marka, Z, Markakis, C, Markosyan, A, Markowitz, A, Maros, E, Marquina, A, Marsat, S, Martelli, F, Martin, I, Martin, R, Martinez, V, Martynov, D, Masalehdan, H, Mason, K, Massera, E, Masserot, A, Massinger, T, Masso-Reid, M, Mastrogiovanni, S, Matas, A, Matichard, F, Matone, L, Mavalvala, N, Mccann, J, Mccarthy, R, Mcclelland, D, Mccormick, S, Mcculler, L, Mcguire, S, Mcisaac, C, Mciver, J, Mcmanus, D, Mcrae, T, Mcwilliams, S, Meacher, D, Meadors, G, Mehmet, M, Mehta, A, Meidam, J, Villa, E, Melatos, A, Mendell, G, Mercer, R, Mereni, L, Merfeld, K, Merilh, E, Merzougui, M, Meshkov, S, Messenger, C, Messick, C, Messina, F, Metzdorff, R, Meyers, P, Meylahn, F, Miani, A, Miao, H, Michel, C, Middleton, H, Milano, L, Miller, A, Millhouse, M, Mills, J, Milovich-Goff, M, Minazzoli, O, Minenkov, Y, Mishkin, A, Mishra, C, Mistry, T, Mitra, S, Mitrofanov, V, Mitselmakher, G, Mittleman, R, Mo, G, Moffa, D, Mogushi, K, Mohapatra, S, Molina-Ruiz, M, Mondin, M, Montani, M, Moore, C, Moraru, D, Morawski, F, Moreno, G, Morisaki, S, Mours, B, Mow-Lowry, C, Muciaccia, F, Mukherjee, A, Mukherjee, D, Mukherjee, S, Mukund, N, Mullavey, A, Munch, J, Muniz, E, Muratore, M, Murray, P, Nagar, A, Nardecchia, I, Naticchioni, L, Nayak, R, Neil, B, Neilson, J, Nelemans, G, Nelson, T, Nery, M, Neunzert, A, Nevin, L, Ng, K, Ng, S, Nguyen, C, Nguyen, P, Nichols, D, Nichols, S, Nissanke, S, Nocera, F, North, C, Nuttall, L, Obergaulinger, M, Oberling, J, O'Brien, B, Oganesyan, G, Ogin, G, Oh, J, Oh, S, Ohme, F, Ohta, H, Okada, M, Oliver, M, Oppermann, P, Oram, R, O'Reilly, B, Ormiston, R, Ortega, L, O'Shaughnessy, R, Ossokine, S, Ottaway, D, Overmier, H, Owen, B, Pace, A, Pagano, G, Page, M, Pagliaroli, G, Pai, A, Pai, S, Palamos, J, Palashov, O, Palomba, C, Pan, H, Panda, P, Pang, P, Pankow, C, Pannarale, F, Pant, B, Paoletti, F, Paoli, A, Parida, A, Parker, W, Pascucci, D, Pasqualetti, A, Passaquieti, R, Passuello, D, Patil, M, Patricelli, B, Payne, E, Pearlstone, B, Pechsiri, T, Pedersen, A, Pedraza, M, Pedurand, R, Pele, A, Penn, S, Perego, A, Perez, C, Perigois, C, Perreca, A, Petermann, J, Pfeiffer, H, Phelps, M, Phukon, K, Piccinni, O, Pichot, M, Piergiovanni, F, Pierro, V, Pillant, G, Pinard, L, Pinto, I, Pirello, M, Pitkin, M, Plastino, W, Poggiani, R, Pong, D, Ponrathnam, S, Popolizio, P, Porter, E, Powell, J, Prajapati, A, Prasad, J, Prasai, K, Prasanna, R, Pratten, G, Prestegard, T, Principe, M, Prodi, G, Prokhorov, L, Punturo, M, Puppo, P, Purrer, M, Qi, H, Quetschke, V, Quinonez, P, Raab, F, Raaijmakers, G, Radkins, H, Radulesco, N, Raffai, P, Raja, S, Rajan, C, Rajbhandari, B, Rakhmanov, M, Ramirez, K, Ramos-Buades, A, Rana, J, Rao, K, Rapagnani, P, Raymond, V, Razzano, M, Read, J, Regimbau, T, Rei, L, Reid, S, Reitze, D, Rettegno, P, Ricci, F, Richardson, C, Richardson, J, Ricker, P, Riemenschneider, G, Riles, K, Rizzo, M, Robertson, N, Robinet, F, Rocchi, A, Rolland, L, Rollins, J, Roma, V, Romanelli, M, Romano, J, Romano, R, Romel, C, Romie, J, Rose, C, Rose, D, Rose, K, Rosinska, D, Rosofsky, S, Ross, M, Rowan, S, Rudiger, A, Ruggi, P, Rutins, G, Ryan, K, Sachdev, S, Sadecki, T, Sakellariadou, M, Salafia, O, Salconi, L, Saleem, M, Samajdar, A, Sammut, L, Sanchez, E, Sanchez, L, Sanchis-Gual, N, Sanders, J, Santiago, K, 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Summerscales, T, Sun, L, Sunil, S, Sur, A, Suresh, J, Sutton, P, Swinkels, B, Szczepanczyk, M, Tacca, M, Tait, S, Talbot, C, Tanner, D, Tao, D, Tapai, M, Tapia, A, Tasson, J, Taylor, R, Tenorio, R, Terkowski, L, Thomas, M, Thomas, P, Thondapu, S, Thorne, K, Thrane, E, Tiwari, S, Tiwari, V, Toland, K, Tonelli, M, Tornasi, Z, Torres-Forne, A, Torrie, C, Toyr, D, Travasso, F, Traylor, G, Tringali, M, Tripathee, A, Trovato, A, Trozzo, L, Tsang, K, Tse, M, Tso, R, Tsukada, L, Tsuna, D, Tsutsui, T, Tuyenbayev, D, Ueno, K, Ugolini, D, Unnikrishnan, C, Urban, A, Usman, S, Vahlbruch, H, Vajente, G, Valdes, G, Valentini, M, Bakel, N, Beuzekom, M, Brand, J, Broeck, C, Vander-Hyde, D, Schaaf, L, Vanheijningen, J, Veggel, A, Vardaro, M, Varma, V, Vass, S, Vasuth, M, Vecchio, A, Vedovato, G, Veitch, J, Veitch, P, Venkateswara, K, Venugopalan, G, Verkindt, D, Vetrano, F, Vicere, A, Viets, A, Vinciguerra, S, Vine, D, Vinet, J, Vitale, S, Vo, T, Vocca, H, Vorvick, C, Vyatchanin, S, Wade, A, Wade, L, 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l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire d'Annecy de Physique des Particules (LAPP), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École Nationale Supérieure des Sciences Appliquées et de Technologie (ENSSAT)-Centre National de la Recherche Scientifique (CNRS), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Collège de France (CdF (institution))-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL), Institut des Hautes Études Scientifiques (IHES), VIRGO, (Astro)-Particles Physics, COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Centre National de la Recherche Scientifique (CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-École Nationale Supérieure des Sciences Appliquées et de Technologie (ENSSAT)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Fédération de recherche du Département de physique de l'Ecole Normale Supérieure - ENS Paris (FRDPENS), Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Collège de France (CdF (institution)), Spectroscopies optiques des matériaux verres, amorphes et à nanoparticules (SOPRANO), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), LIGO Scientific Collaboration, Virgo Collaboration, Arène, M., Bécsy, B., Bustillo, J. Calderón, Diaz, J. Casanueva, Cavaglià, M., Cerdá-Durán, P., Cieślar, M., Cordero-Carrión, I., Dálya, G., D’Angelo, B., D’Antonio, S., Deléglise, S., Pozzo, W. Del, de Varona, O., Díaz, M. C., Vivanco, Francisco Hernandez, Fronzè, G., García-Quirós, C., Ghosh, Abhirup, Ghosh, Archisman, González, G., Gupta, Anchal, Hübner, M. T., Kéfélian, F., Kim, Chunglee, Krämer, C., Królak, A., Kumar, Rahul, Kumar, Rakesh, Lück, H., Hernandez, I. Magaña, Magaña-Sandoval, F., Márka, S., Márka, Z., Villa, E. Mejuto, Mukherjee, Arunava, Mukherjee, Subroto, Muñiz, E. A., O’Brien, B. D., Oram, Richard J., O’Reilly, B., O’Shaughnessy, R., Périgois, C., Pinto, I. M., Pürrer, M., Rana, Javed, Rosińska, D., Rüdiger, A., Schönbeck, A., Szczepańczyk, M. J., Tápai, M., Tiwari, Shubhanshu, Tiwari, Srishti, Torres-Forné, A., Töyrä, D., Bakel, N. van, Beuzekom, M. van, Brand, J. F. J. van den, Broeck, C. Van Den, Schaaf, L. van der, Veggel, A. A. van, Vasúth, M., Viceré, A., Weßels, P., Yu, Hang, Yu, Haocun, Zadrożny, A. K., Zadrożny, A., RS: FSE MSP, Grav. waves and fundamental physics, RS: FSE Grav. waves and fundamental physics, Faculty of Science, Gravitation and Astroparticle Physics Amsterdam, Other Research IHEF (IoP, FNWI), IoP (FNWI), and Astroparticle Physics (IHEF, IoP, FNWI)
Subjects: Gravitació, neutron star: binary, cosmological model, 010504 meteorology & atmospheric sciences, Astronomy, Gravitational Waves, Hubble constant, O2, LIGO, Virgo, detector: network, 01 natural sciences, Cosmology, General Relativity and Quantum Cosmology, LIGO, dark energy, 010303 astronomy & astrophysics, QC, Physics, Settore FIS/01, Hubble constant, Settore FIS/05, CATALOG, Physical Sciences, symbols, [PHYS.GRQC]Physics [physics]/General Relativity and Quantum Cosmology [gr-qc], Astrophysics - Cosmology and Nongalactic Astrophysics, Cosmology and Nongalactic Astrophysics (astro-ph.CO), DATA RELEASE, COSMOLOGICAL PARAMETERS, FOS: Physical sciences, O2, General Relativity and Quantum Cosmology (gr-qc), Astrophysics::Cosmology and Extragalactic Astrophysics, Astronomy & Astrophysics, LUMINOSITY FUNCTIONS, gravitational radiation: direct detection, Gravitational-wave astronomy, 1ST, Article, electromagnetic field: production, symbols.namesake, Binary black hole, 0103 physical sciences, DISTRIBUTIONS, K-CORRECTIONS, SDG 7 - Affordable and Clean Energy, Astrophysique, STFC, 0105 earth and related environmental sciences, Gravitational Waves, Science & Technology, Gravitational wave, Virgo, RCUK, Astronomy and Astrophysics, cosmology, gravitational waves, 310 Galaxies and Cosmology, Galaxy, EVOLUTION, Dewey Decimal Classification::500 | Naturwissenschaften::520 | Astronomie, Kartographie, gravitational radiation detector, VIRGO, black hole: binary, Space and Planetary Science, [SDU]Sciences of the Universe [physics], DENSITY, gravitational radiation: emission, Dark energy, Astronomia, ddc:520, galaxy, Gravitational wave astronomy, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Hubble's law
Abstract: This paper presents the gravitational-wave measurement of the Hubble constant (H 0) using the detections from the first and second observing runs of the Advanced LIGO and Virgo detector network. The presence of the transient electromagnetic counterpart of the binary neutron star GW170817 led to the first standard-siren measurement of H 0. Here we additionally use binary black hole detections in conjunction with galaxy catalogs and report a joint measurement. Our updated measurement is H 0 = km s-1 Mpc-1 (68.3% of the highest density posterior interval with a flat-in-log prior) which is an improvement by a factor of 1.04 (about 4%) over the GW170817-only value of km s-1 Mpc-1. A significant additional contribution currently comes from GW170814, a loud and well-localized detection from a part of the sky thoroughly covered by the Dark Energy Survey. With numerous detections anticipated over the upcoming years, an exhaustive understanding of other systematic effects are also going to become increasingly important. These results establish the path to cosmology using gravitational-wave observations with and without transient electromagnetic counterparts., 0, info:eu-repo/semantics/published
Published: 2021

35. αvβ8 integrin-expression by BATF3-dependent dendritic cells facilitates early IgA responses to Rotavirus

Author: Bernard Malissen, Joy Nakawesi, Julia Hütter, Sébastien This, Harry B. Greenberg, L. J. Gooday, A. Garcias López, V. Barateau, Katharina Lahl, K. Getachew Muleta, K. Fog Thomsen, Olivier Thaunat, M. Boucard-Jourdin, T. Defrance, Didier Poncet, Isabel Ulmert, H. Paidassi, Centre d'Immunologie de Marseille - Luminy (CIML), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Centre International de Recherche en Infectiologie - UMR (CIRI), Institut National de la Santé et de la Recherche Médicale (INSERM)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Lund University [Lund], Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Technical University of Denmark - Division of Biopharma - Institut for Health Tech - Kongens, Berlin Institute of Health (BIH), Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Stanford University School of Medicine [CA, USA], VA Palo Alto Health Care System, Lymphocytes B effecteurs et à mémoire – Effector and memory B cells, Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), ANR-13-PDOC-0019,InteReg,Régulation de l'expression de l'intégrine alpha-v-beta-8 et son rôle dans le maintien de l'homéostasie immunitaire de l'intestin(2013), Biologie Moléculaire des Rotavirus (ROTA), Département Virologie (Dpt Viro), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Saclay, Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Saclay-Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Saclay-Institut de Biologie Intégrative de la Cellule (I2BC), Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Saclay-Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Saclay, Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Paul Scherrer Institute (PSI), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Rotavirus, 0301 basic medicine, Integrins, HOMEOSTASIS, [SDV]Life Sciences [q-bio], Immunology, Integrin, Context (language use), Antibodies, Viral, medicine.disease_cause, [SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity, Rotavirus Infections, Virus, ACTIVATION, 03 medical and health sciences, 0302 clinical medicine, Antibody Specificity, INFECTION, TGF beta signaling pathway, medicine, Immunology and Allergy, Mesenteric lymph nodes, TGF-BETA-1, REGULATORY T-CELLS, ComputingMilieux_MISCELLANEOUS, TGF beta 1, biology, GROWTH-FACTOR-BETA, INDUCTION, TGF-BETA, Dendritic Cells, Immunoglobulin A, 3. Good health, Basic-Leucine Zipper Transcription Factors, 030104 developmental biology, medicine.anatomical_structure, [SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology, EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS, B-CELLS, Host-Pathogen Interactions, Immunoglobulin A, Secretory, biology.protein, Cytokines, [SDV.IMM]Life Sciences [q-bio]/Immunology, Homeostasis, 030215 immunology
Abstract: International audience; Secretory intestinal IgA can protect from re-infection with rotavirus (RV), but very little is known about the mechanisms that induce IgA production during intestinal virus infections. Classical dendritic cells (cDCs) in the intestine can facilitate both T cell-dependent and -independent secretory IgA. Here, we show that BATF3-dependent cDC1, but not cDC2, are critical for the optimal induction of RV-specific IgA responses in the mesenteric lymph nodes. This depends on the selective expression of the TGF beta-activating integrin alpha v beta 8 by cDC1. In contrast, alpha v beta 8 on cDC1 is dispensible for steady state immune homeostasis. Given that cDC2 are crucial in driving IgA during steady state but are dispensable for RV-specific IgA responses, we propose that the capacity of DC subsets to induce intestinal IgA responses reflects the context, as opposed to an intrinsic property of individual DC subsets.
Published: 2021

36. Blood microbiota and metabolomic signature of major depression before and after antidepressant treatment: a prospective case–control study

Author: Ciocan, Dragos, Cassard, Anne-Marie, Becquemont, Laurent, Verstuyft, Céline, Voican, Cosmin Sebastian, El Asmar, Khalil, Colle, Romain, David, Denis, Trabado, Séverine, Fève, Bruno, Chanson, Philippe, Perlemuter, Gabriel, Corruble, Emmanuelle, AP-HP - Hôpital Antoine Béclère [Clamart], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Cytokines, chimiokines et immunopathologie, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM), Inflammation, microbiome, immunosurveillance (MI2), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Service de psychiatrie [Le Kremlin-Bicêtre], Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bicêtre, Service de Génétique Moléculaire Pharmacogénétique et Hormonologie [CHU Bicêtre], AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Hôpital Bicêtre, Signalisation Hormonale, Physiopathologie Endocrinienne et Métabolique, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Centre de Recherche Saint-Antoine (CRSA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Lipodystrophies, adaptations métaboliques et hormonales, et vieillissement [CRSA], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre de référence des maladies rares de l'hypophyse (HYPO), Service d'Endocrinologie, Diabète et Maladies Métaboliques, and Feve, Bruno
Subjects: Adult, Male, Depressive Disorder, Major, Bacteria, [SDV]Life Sciences [q-bio], Microbiota, Lipid Metabolism, Antidepressive Agents, Gastrointestinal Microbiome, [SDV] Life Sciences [q-bio], Blood, Case-Control Studies, Brain-Gut Axis, Metabolome, Carbohydrate Metabolism, Dysbiosis, Humans, Female, Research Paper
Abstract: International audience; Background: The microbiota interacts with the brain through the gut-brain axis, and a distinct dysbiosis may lead to major depressive episodes. Bacteria can pass through the gut barrier and be found in the blood. Using a multiomic approach, we investigated whether a distinct blood microbiome and metabolome was associated with major depressive episodes, and how it was modulated by treatment.Methods: In this case-control multiomic study, we analyzed the blood microbiome composition, inferred bacterial functions and metabolomic profile of 56 patients experiencing a current major depressive episode and 56 matched healthy controls, before and after treatment, using 16S rDNA sequencing and liquid chromatography coupled to tandem mass spectrometry.Results: The baseline blood microbiome in patients with a major depressive episode was distinct from that of healthy controls (patients with a major depressive episode had a higher proportion of Janthinobacterium and lower levels of Neisseria) and changed after antidepressant treatment. Predicted microbiome functions confirmed by metabolomic profiling showed that patients who were experiencing a major depressive episode had alterations in the cyanoamino acid pathway at baseline. High baseline levels of Firmicutes and low proportions of Bosea and Tetrasphaera were associated with response to antidepressant treatment. Based on inferred baseline metagenomic profiles, bacterial pathways that were significantly associated with treatment response were related to xenobiotics, amino acids, and lipid and carbohydrate metabolism, including tryptophan and drug metabolism. Metabolomic analyses showed that plasma tryptophan levels are independently associated with response to antidepressant treatment.Limitations: Our study has some limitations, including a lack of information on blood microbiome origin and the lack of a validation cohort to confirm our results.Conclusion: Patients with depression have a distinct blood microbiome and metabolomic signature that changes after treatment. Dysbiosis could be a new therapeutic target and prognostic tool for the treatment of patients who are experiencing a major depressive episode.
Published: 2021

37. In silico and Functional Studies for Classification of EPAS1/HIF2A Genetic Variants Identified in Patients with Erythrocytosis

Author: Karaghiannis, Valéna, Maric, Darko, Garrec, Céline, Maaziz, Nada, Buffet, Alexandre, Antunes, Vincent, Le Roy, Amandine, Airaud, Fabrice, Aral, Bernard, Schmitt, Loic, Corbineau, Sébastien, Mansour-Hendili, Lamisse, Lesieur, Valentine, Rimbert, Antoine, Laporte, Fabien, Delamare, Marine, Bezieau, Stephane, Cassinat, Bruno, Galactéros, Frédéric, Gimenez-Roqueplo, Anne-Paule, Burnichon, Nelly, Cario, Holger, Wijk, Richard Van, Bento, Celeste, Blouet, Anaise, Bouteloup, Juliette, Boyer Perrard, Françoise, Bruce, Aisha Aiko, Cayssials, Emilie, Casadevall, Nicole, Cherel, Brieuc, Couec, Marielaure, Drevon, Louis, Dumesnil, Cecile, Lamy de la Chapelle, Thierry, Gambart, Marion, Garcon, Loic, Granel, Brigitte, Hirsch, Pierre, Lahary, Agnès, Mejri, Amira, Meunier, Sandrine, Nicolini, Franck, Raffoux, Emmanuel, Ranta, Dana, Schleinitz, Nicolas, Valentin, Jean Baptiste, Wemeau, Mathieu, Girodon, Francois, Hoogewijs, David, Gardie, Betty, Hermine, Olivier, Université de Fribourg = University of Fribourg (UNIFR), Centre hospitalier universitaire de Nantes (CHU Nantes), Paris-Centre de Recherche Cardiovasculaire (PARCC (UMR_S 970/ U970)), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL), Cardiology Department, Thorax Clinic Institute, Hospital Cliınic, Institut d'Investigacions Biomèdiques [Barcelona], Universitat de Barcelona (UB), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Université Sorbonne Paris Cité (USPC), Réparation et Transcription dans les cellules Souches (Equipe - U967 INSERM), Stabilité génétique, Cellules Souches et Radiations (SCSR (U_967)), Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Hôpital Henri Mondor, Génétique Quantitative et Evolution - Le Moulon (Génétique Végétale) (GQE-Le Moulon), AgroParisTech-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre de recherche en Myologie – U974 SU-INSERM, Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), IMRB - 'Transfusion et Maladies du Globule Rouge' [Créteil] (U955 Inserm - UPEC), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Laboratoire d'Excellence : Biogenèse et pathologies du globule rouge (Labex Gr-Ex), Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Université Paris Cité (UPCité), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Centre de Références Cancers Rares (PREDIR), INCA, Institut national du cancer [Boulogne] (INCA), CHU Amiens-Picardie, HEMATIM - Hématopoïèse et immunologie - UR UPJV 4666 (HEMATIM), and Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: Immunology, Cell Biology, Hematology, Biochemistry, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: International audience
Published: 2022

38. Avis de l'Anses relatif à l’évaluation des risques liés à la consommation de compléments alimentaires contenant du curcuma

Author: Nesslany, Fabrice, Boutefnouchet, Sabrina, Champy, Pierre, Dufat, Hanh, Girardot, Marion, Hennebelle, Thierry, Lacaille-Dubois, Marie-Aleth, Michalet, Serge, Rivière, Céline, Souard, Florence, Vuitton, Dominique Angèle, Weniger, Bernard, Huret, Fanny, Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP), Université Paris Descartes, Sorbonne Paris Cité, Université Paris-Sud - Paris 11 - Faculté de médecine (UP11 UFR Médecine), Université Paris-Sud - Paris 11 (UP11), Ecologie et biologie des interactions (EBI), Université de Poitiers-Centre National de la Recherche Scientifique (CNRS), Université de Lille, Université Bourgogne Franche-Comté [COMUE] (UBFC), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Université Grenoble Alpes - UFR Médecine - Département de Maïeutique (UGA UFRMDM), Université Grenoble Alpes (UGA), Retraité, Direction de l'Evaluation des Risques (DER), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), and Anses
Subjects: Compléments alimentaires, curcumine, plantes, plant extracts, plants, Food supplements, [SDV]Life Sciences [q-bio], turmeric, préparation de plantes, curcumin, curcuma
Abstract: Citation suggérée : Anses. (2022) Avis de l’Anses relatif à l’évaluation des risques liés à la consommation de compléments alimentairescontenant du curcuma (autosaisine 2019-SA-0111). Maisons-Alfort : Anses, 178 p; L’utilisation de plantes dans les compléments alimentaires est encadrée par le décret n°2006-352 du 20 mars 2006 et par l’arrêté du 24 juin 2014 ci-après dénommé « arrêté plantes ».De nombreux compléments alimentaires contenant du curcuma ou sa substance active, la curcumine, sont disponibles sur le marché français, notamment pour leurs potentielles propriétés digestives, antioxydantes et anti-inflammatoires. Entre mai 2016 et mars 2021, plus de 1600 produitscontenant du curcuma ou de la curcumine ont été déclarés à la DGCCRF par Téléicare. Cette plante ne figure pas dans l’annexe I de l’arrêté du 24 juin 2014 établissant la liste des plantes, autres que les champignons, autorisées dans les compléments alimentaires et leurs conditions d’emploi Cette liste a été consolidée et publiée par la DGCCRF en janvier 20195, trois espèces de curcuma y sont présentes : Curcuma longa L., Curcuma xanthorrhiza Roxb. et Curcuma zedoaria (Christm.) Roscoe mais aucune recommandation sanitaire n’est attachée à ces trois espèces.À ce jour, une demande d’allégation pour la curcumine entrant dans la composition de denrées alimentaires a été déposée et évaluée par l’autorité européenne de sécurité des aliments (Efsa), qui a estimé qu’une relation de cause à effet n’était pas établie entre la consommation de cettesubstance et la « contribution au fonctionnement normal des articulations ». Ainsi, aucune allégation n’a été autorisée par la Commission européenne (règlement (UE) n° 432/2012).Une dose journalière admissible (DJA) de 3 mg/kg pc/j, fondée sur l’observation d’une diminution de la croissance pondérale de la seconde génération de rats exposés à la plus forte dose lors d’une étude de toxicité développementale, a été fixée pour la curcumine, qui est largement utilisée commecolorant (E100) dans l’alimentation (Jecfa 2004). La consommation actuelle de certains compléments alimentaires contenant de la curcumine, notamment ceux dans lesquels sa biodisponibilité est augmentée par l’association à d’autres ingrédients tels que la pipérine ou par l’utilisation de nouvelles formulations, peut entraîner un dépassement de cette DJA.Par ailleurs, depuis la mise en place du dispositif de nutrivigilance en 2009, 120 signalements d’effets indésirables susceptibles d’être liés à la consommation de compléments alimentaires contenant du curcuma ou de la curcumine ont été portés à la connaissance de l’Anses. Parmi ces120 déclarations, 67 ont fait l’objet d’une analyse d’imputabilité par le groupe de travail de nutrivigilance. Les effets indésirables les plus fréquemment rapportés sont notamment d’ordre hépatique avec 15 signalements analysables. Par ailleurs, l’Italie a recensé entre novembre 2018 etjuin 2019 une vingtaine de cas spontanés d’hépatite impliquant le curcuma (seul ou en association avec d’autres ingrédients) (Menniti-Ippolito et al. 2020).Dans ce contexte, l’Anses a décidé de s’autosaisir afin de mener un état des lieux des connaissances sur cette plante, d’estimer l’exposition de la population française à la curcumine présente dans l’alimentation et, le cas échéant, de protéger les populations sensibles et les plus exposées par la formulation de recommandations.
Published: 2022

39. Grain carbon isotope composition is a marker for allocation and harvest index in wheat

Author: Jean‐Baptiste Domergue, Cyril Abadie, Julie Lalande, Jean‐Charles Deswarte, Eric Ober, Valérie Laurent, Céline Zimmerli, Philippe Lerebour, Laure Duchalais, Camille Bédard, Jérémy Derory, Thierry Moittie, Marlène Lamothe‐Sibold, Katia Beauchêne, Anis M. Limami, Guillaume Tcherkez, Institut de Recherche en Horticulture et Semences (IRHS), Université d'Angers (UA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Rennes Angers, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), ARVALIS - Institut du végétal [Paris], Natl Inst Agr Bot, Cambridge, England, Partenaires INRAE, Physiopathologie et Thérapeutiques Respiratoires, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10, Département de Biologie Moléculaire Végétale, Université de Lausanne = University of Lausanne (UNIL), UNISIGMA, Société Ragt 2N, RAGT 2n, Biodiversité, Gènes & Communautés (BioGeCo), Université de Bordeaux (UB)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Union Française des Semenciers (UFS), Institut des Sciences des Plantes de Paris-Saclay (IPS2 (UMR_9213 / UMR_1403)), Institut National de la Recherche Agronomique (INRA)-Université Paris-Sud - Paris 11 (UP11)-Université Paris Diderot - Paris 7 (UPD7)-Université d'Évry-Val-d'Essonne (UEVE)-Centre National de la Recherche Scientifique (CNRS), IRHS - Équipe SMS (Source and sink Metabolism and Stress responses) (IRHS-SMS), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Université d'Angers (UA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Rennes Angers, Région Pays de la Loire, Institut de Biologie des Plantes (IBP), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Chimie Et Interdisciplinarité : Synthèse, Analyse, Modélisation (CEISAM), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), ARVALIS - Institut du Végétal, Université d'Angers (UA), and DUPRE, Olivier
Subjects: carbon 13, Carbon Isotopes, Physiology, food and beverages, Plant Science, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Carbon, post-photosynthetic fractionation, Plant Leaves, Plant Breeding, partitioning, respiration use efficiency, Edible Grain, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, Triticum
Abstract: International audience; The natural C-13 abundance (delta C-13) in plant leaves has been used for decades with great success in agronomy to monitor water-use efficiency and select modern cultivars adapted to dry conditions. However, in wheat, it is also important to find genotypes with high carbon allocation to spikes and grains, and thus with a high harvest index (HI) and/or low carbon losses via respiration. Finding isotope-based markers of carbon partitioning to grains would be extremely useful since isotope analyses are inexpensive and can be performed routinely at high throughput. Here, we took the advantage of a set of field trials made of more than 600 plots with several wheat cultivars and measured agronomic parameters as well as delta C-13 values in leaves and grains. We find a linear relationship between the apparent isotope discrimination between leaves and grain (denoted as Delta delta(corr)), and the respiration use efficiency-to-HI ratio. It means that overall, efficient carbon allocation to grains is associated with a small isotopic difference between leaves and grains. This effect is explained by postphotosynthetic isotope fractionations, and we show that this can be modelled by equations describing the carbon isotope composition in grains along the wheat growth cycle. Our results show that C-13 natural abundance in grains could be useful to find genotypes with better carbon allocation properties and assist current wheat breeding technologies.
Published: 2022

40. QUBIC V:Cryogenic system design and performance

Author: Masi, S., Battistelli, E.S., De Bernardis, P., Chapron, C., Columbro, F., D'Alessandro, G., De Petris, M., Grandsire, L., Hamilton, J.-Ch., Marnieros, S., Mele, L., May, A., Mennella, A., O'Sullivan, C., Paiella, A., Piacentini, F., Piat, M., Piccirillo, L., Presta, G., Schillaci, A., Tartari, A., Thermeau, J.-P., Torchinsky, S.A., Voisin, F., Zannoni, M., Ade, P., Alberro, J.G., Almela, A., Amico, G., Arnaldi, L.H., Auguste, D., Aumont, J., Azzoni, S., Banfi, S., Bélier, B., Baù, A., Bennett, D., Bergé, L., Bernard, J.-Ph., Bersanelli, M., Bigot-Sazy, M.-A., Bonaparte, J., Bonis, J., Bunn, E., Burke, D., Buzi, D., Cavaliere, F., Chanial, P., Charlassier, R., Cerutti, A.C. Cobos, Coppolecchia, A., De Gasperis, G., De Leo, M., Dheilly, S., Duca, C., Dumoulin, L., Etchegoyen, A., Fasciszewski, A., Ferreyro, L.P., Fracchia, D., Franceschet, C., Lerena, M.M. Gamboa, Ganga, K.M., García, B., Redondo, M.E. García, Gaspard, M., Gayer, D., Gervasi, M., Giard, M., Gilles, V., Giraud-Heraud, Y., Berisso, M. Gómez, González, M., Gradziel, M., Hampel, M.R., Harari, D., Henrot-Versillé, S., Incardona, F., Jules, E., Kaplan, J., Kristukat, C., Lamagna, L., Loucatos, S., Louis, T., Maffei, B., Marty, W., Mattei, A., McCulloch, M., Melo, D., Montier, L., Mousset, L., Mundo, L.M., Murphy, J.A., Murphy, J.D., Nati, F., Olivieri, E., Oriol, C., Pajot, F., Passerini, A., Pastoriza, H., Pelosi, A., Perbost, C., Perciballi, M., Pezzotta, F., Pisano, G., Platino, M., Polenta, G., Prêle, D., Puddu, R., Rambaud, D., Rasztocky, E., Ringegni, P., Romero, G.E., Salum, J.M., Scóccola, C.G., Scully, S., Spinelli, S., Stankowiak, G., Stolpovskiy, M., Supanitsky, A.D., Timbie, P., Tomasi, M., Tucker, G., Tucker, C., Viganò, D., Vittorio, N., Wicek, F., Wright, M., Zullo, A., Masi, S, Battistelli, E, de Bernardis, P, Chapron, C, Columbro, F, Coppolecchia, A, D'Alessandro, G, De Petris, M, Grandsire, L, Hamilton, J, Lamagna, L, Marnieros, S, May, A, Mele, L, Mennella, A, O'Sullivan, C, Paiella, A, Piacentini, F, Piat, M, Piccirillo, L, Presta, G, Schillaci, A, Tartari, A, Thermeau, J, Torchinsky, S, Voisin, F, Zannoni, M, Ade, P, Alberro, J, Almela, A, Amico, G, Arnaldi, L, Auguste, D, Aumont, J, Azzoni, S, Banfi, S, Baù, A, Bélier, B, Bennett, D, Bergé, L, Bernard, J, Bersanelli, M, Bigot-Sazy, M, Bonaparte, J, Bonis, J, Bunn, E, Burke, D, Buzi, D, Cavaliere, F, Chanial, P, Charlassier, R, Cobos Cerutti, A, De Gasperis, G, De Leo, M, Dheilly, S, Duca, C, Dumoulin, L, Etchegoyen, A, Fasciszewski, A, Ferreyro, L, Fracchia, D, Franceschet, C, Gamboa Lerena, M, Ganga, K, García, B, García Redondo, M, Gaspard, M, Gayer, D, Gervasi, M, Giard, M, Gilles, V, Giraud-Heraud, Y, Gómez Berisso, M, González, M, Gradziel, M, Hampel, M, Harari, D, Henrot-Versillé, S, Incardona, F, Jules, E, Kaplan, J, Kristukat, C, Loucatos, S, Louis, T, Maffei, B, Marty, W, Mattei, A, Mcculloch, M, Melo, D, Montier, L, Mousset, L, Mundo, L, Murphy, J, Nati, F, Olivieri, E, Oriol, C, Pajot, F, Passerini, A, Pastoriza, H, Pelosi, A, Perbost, C, Perciballi, M, Pezzotta, F, Pisano, G, Platino, M, Polenta, G, Prêle, D, Puddu, R, Rambaud, D, Rasztocky, E, Ringegni, P, Romero, G, Salum, J, Scóccola, C, Scully, S, Spinelli, S, Stankowiak, G, Stolpovskiy, M, Supanitsky, A, Timbie, P, Tomasi, M, Tucker, C, Tucker, G, Viganò, D, Vittorio, N, Wicek, F, Wright, M, Zullo, A, AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Observatoire de Paris - Site de Paris (OP), Centre National de la Recherche Scientifique (CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS), Institut de recherche en astrophysique et planétologie (IRAP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Centre de Nanosciences et de Nanotechnologies [Orsay] (C2N), Université Paris-Sud - Paris 11 (UP11)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), QUBIC, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), and Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES)
Subjects: CMBR polarisation, Physics - Instrumentation and Detectors, Manchester Cancer Research Centre, Physics::Instrumentation and Detectors, ResearchInstitutes_Networks_Beacons/mcrc, Astrophysics::Instrumentation and Methods for Astrophysics, FOS: Physical sciences, Astronomy and Astrophysics, Instrumentation and Detectors (physics.ins-det), FIS/05 - ASTRONOMIA E ASTROFISICA, FIS/01 - FISICA SPERIMENTALE, CMBR experiments, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], CMBR detectors, CMBR experiment, Astrophysics - Instrumentation and Methods for Astrophysics, gravitational waves and CMBR polarization, Instrumentation and Methods for Astrophysics (astro-ph.IM), CMBR detector
Abstract: Current experiments aimed at measuring the polarization of the Cosmic Microwave Background (CMB) use cryogenic detector arrays and cold optical systems to boost the mapping speed of the sky survey. For these reasons, large volume cryogenic systems, with large optical windows, working continuously for years, are needed. Here we report on the cryogenic system of the QUBIC (Q and U Bolometric Interferometer for Cosmology) experiment: we describe its design, fabrication, experimental optimization and validation in the Technological Demonstrator configuration. The QUBIC cryogenic system is based on a large volume cryostat, using two pulse-tube refrigerators to cool at ~3K a large (~1 m^3) volume, heavy (~165kg) instrument, including the cryogenic polarization modulator, the corrugated feedhorns array, and the lower temperature stages; a 4He evaporator cooling at ~1K the interferometer beam combiner; a 3He evaporator cooling at ~0.3K the focal-plane detector arrays. The cryogenic system has been tested and validated for more than 6 months of continuous operation. The detector arrays have reached a stable operating temperature of 0.33K, while the polarization modulator has been operated from a ~10K base temperature. The system has been tilted to cover the boresight elevation range 20 deg -90 deg without significant temperature variations. The instrument is now ready for deployment to the high Argentinean Andes., Comment: This is one of a series of papers on the QUBIC experiment status - This version of the paper matches the one accepted for publication on Journal of Cosmology and Astroparticle Physics
Published: 2022

41. QUBIC VIII: Optical design and performance

Author: O'Sullivan, C., de Petris, M., Amico, G., Battistelli, E.S., Burke, D., Buzi, D., Chapron, C., Conversi, L., d'Alessandro, G., de Bernardis, P., de Leo, M., Gayer, D., Grandsire, L., Hamilton, J.-Ch., Marnieros, S., Masi, S., Mattei, A., Mennella, A., Mousset, L., Murphy, J.D., Pelosi, A., Perciballi, M., Piat, M., Scully, S., Tartari, A., Torchinsky, S.A., Voisin, F., Zannoni, M., Zullo, A., Ade, P., Alberro, J.G., Almela, A., Arnaldi, L.H., Auguste, D., Aumont, J., Azzoni, S., Banfi, S., Bélier, B., Baù, A., Bennett, D., Bergé, L., Bernard, J.-Ph., Bersanelli, M., Bigot-Sazy, M.-A., Bonaparte, J., Bonis, J., Bunn, E., Cavaliere, F., Chanial, P., Charlassier, R., Cerutti, A.C. Cobos, Columbro, F., Coppolecchia, A., de Gasperis, G., Dheilly, S., Duca, C., Dumoulin, L., Etchegoyen, A., Fasciszewski, A., Ferreyro, L.P., Fracchia, D., Franceschet, C., Lerena, M.M. Gamboa, Ganga, K.M., García, B., Redondo, M.E. García, Gaspard, M., Gervasi, M., Giard, M., Gilles, V., Giraud-Heraud, Y., Gomezberisso, M., Gómez Berisso, M., González, M., Gradziel, M., Hampel, M.R., Harari, D., Henrot-Versillé, S., Incardona, F., Jules, E., Kaplan, J., Kristukat, C., Lamagna, L., Loucatos, S., Louis, T., Maffei, B., Marty, W., May, A., Mcculloch, M., Mele, L., Melo, D., Montier, L., Mundo, L.M., Murphy, J.A., Nati, F., Olivieri, E., Oriol, C., Paiella, A., Pajot, F., Passerini, A., Pastoriza, H., Perbost, C., Pezzotta, F., Piacentini, F., Piccirillo, L., Pisano, G., Platino, M., Polenta, G., Prêle, D., Puddu, R., Rambaud, D., Ringegni, P., Romero, G.E., Rasztocky, E., Salum, J.M., Schillaci, A., Scóccola, C., Spinelli, S., Stankowiak, G., Stolpovskiy, M., Supanitsky, A.D., Thermeau, J.-P., Timbie, P., Tomasi, M., Tucker, G., Tucker, C., Viganò, D., Vittorio, N., Wicek, F., Wright, M., O'Sullivan, C, De Petris, M, Amico, G, Battistelli, E, de Bernardis, P, Burke, D, Buzi, D, Chapron, C, Conversi, L, D'Alessandro, G, De Leo, M, Gayer, D, Grandsire, L, Hamilton, J, Marnieros, S, Masi, S, Mattei, A, Mennella, A, Mousset, L, Murphy, J, Pelosi, A, Perciballi, M, Piat, M, Scully, S, Tartari, A, Torchinsky, S, Voisin, F, Zannoni, M, Zullo, A, Ade, P, Alberro, J, Almela, A, Arnaldi, L, Auguste, D, Aumont, J, Azzoni, S, Banfi, S, Baù, A, Bélier, B, Bennett, D, Bergé, L, Bernard, J, Bersanelli, M, Bigot-Sazy, M, Bonaparte, J, Bonis, J, Bunn, E, Cavaliere, F, Chanial, P, Charlassier, R, Cobos Cerutti, A, Columbro, F, Coppolecchia, A, De Gasperis, G, Dheilly, S, Duca, C, Dumoulin, L, Etchegoyen, A, Fasciszewski, A, Ferreyro, L, Fracchia, D, Franceschet, C, Gamboa Lerena, M, Ganga, K, García, B, García Redondo, M, Gaspard, M, Gervasi, M, Giard, M, Gilles, V, Giraud-Heraud, Y, Gómez Berisso, M, González, M, Gradziel, M, Hampel, M, Harari, D, Henrot-Versillé, S, Incardona, F, Jules, E, Kaplan, J, Kristukat, C, Lamagna, L, Loucatos, S, Louis, T, Maffei, B, Marty, W, May, A, Mcculloch, M, Mele, L, Melo, D, Montier, L, Mundo, L, Nati, F, Olivieri, E, Oriol, C, Paiella, A, Pajot, F, Passerini, A, Pastoriza, H, Perbost, C, Pezzotta, F, Piacentini, F, Piccirillo, L, Pisano, G, Platino, M, Polenta, G, Prêle, D, Puddu, R, Rambaud, D, Rasztocky, E, Ringegni, P, Romero, G, Salum, J, Schillaci, A, Scóccola, C, Spinelli, S, Stankowiak, G, Stolpovskiy, M, Supanitsky, A, Thermeau, J, Timbie, P, Tomasi, M, Tucker, C, Tucker, G, Viganò, D, Vittorio, N, Wicek, F, Wright, M, AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Observatoire de Paris - Site de Paris (OP), Centre National de la Recherche Scientifique (CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS), Institut de recherche en astrophysique et planétologie (IRAP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Centre de Nanosciences et de Nanotechnologies [Orsay] (C2N), Université Paris-Sud - Paris 11 (UP11)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), QUBIC, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), and Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES)
Subjects: CMBR polarisation, Cosmology and Nongalactic Astrophysics (astro-ph.CO), Manchester Cancer Research Centre, ResearchInstitutes_Networks_Beacons/mcrc, Astrophysics::Instrumentation and Methods for Astrophysics, FOS: Physical sciences, Astronomy and Astrophysics, CMBR experiments, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], CMBR detectors, CMBR experiment, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], gravitational waves and CMBR polarization, Astrophysics - Instrumentation and Methods for Astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM), CMBR detector, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: The Q and U Bolometric Interferometer for Cosmology (QUBIC) is a ground-based experiment that aims to detect B-mode polarisation anisotropies in the CMB at angular scales around the l=100 recombination peak. Systematic errors make ground-based observations of B modes at millimetre wavelengths very challenging and QUBIC mitigates these problems in a somewhat complementary way to other existing or planned experiments using the novel technique of bolometric interferometry. This technique takes advantage of the sensitivity of an imager and the systematic error control of an interferometer. A cold reflective optical combiner superimposes there-emitted beams from 400 aperture feedhorns on two focal planes. A shielding system composedof a fixed groundshield, and a forebaffle that moves with the instrument, limits the impact of local contaminants. The modelling, design, manufacturing and preliminary measurements of the optical components are described in this paper., Part of a series of 8 papers on QUBIC to be published in a special issue of JCAP. Accepted for publication
Published: 2022

42. QUBIC VII: The feedhorn-switch system of the technological demonstrator

Author: F. Cavaliere, A. Mennella, M. Zannoni, P. Battaglia, E. S. Battistelli, D. Burke, G. D’Alessandro, P. de Bernardis, M. De Petris, C. Franceschet, L. Grandsire, J. -Ch. Hamilton, B. Maffei, E. Manzan, S. Marnieros, S. Masi, C. O’Sullivan, A. Passerini, F. Pezzotta, M. Piat, A. Tartari, S. A. Torchinsky, D. Viganò, F. Voisin, P. Ade, J. G. Alberro, A. Almela, G. Amico, L. H. Arnaldi, D. Auguste, J. Aumont, S. Azzoni, B. Bélier, A. Baù, S. Banfi, D. Bennett, L. Bergé, J. -Ph. Bernard, M. Bersanelli, M. -A. Bigot-Sazy, J. Bonaparte, J. Bonis, E. Bunn, D. Buzi, P. Chanial, C. Chapron, R. Charlassier, A. C. Cobos Cerutti, F. Columbro, A. Coppolecchia, G. De Gasperis, M. De Leo, S. Dheilly, C. Duca, L. Dumoulin, A. Etchegoyen, A. Fasciszewski, L. P. Ferreyro, D. Fracchia, M. Gómez Berisso, M. M. Gamboa Lerena, K. M. Ganga, B. García, M. E. García Redondo, M. Gaspard, D. Gayer, M. Gervasi, M. Giard, V. Gilles, Y. Giraud-Heraud, M. González, M. Gradziel, M. R. Hampel, D. Harari, S. Henrot-Versillé, F. Incardona, E. Jules, J. Kaplan, C. Kristukat, L. Lamagna, S. Loucatos, T. Louis, W. Marty, A. Mattei, A. May, M. McCulloch, L. Mele, D. Melo, L. Montier, L. Mousset, L. M. Mundo, J. A. Murphy, J. D. Murphy, F. Nati, E. Olivieri, C. Oriol, E. Pagana, A. Paiella, F. Pajot, H. Pastoriza, A. Pelosi, C. Perbost, M. Perciballi, F. Piacentini, L. Piccirillo, G. Pisano, M. Platino, G. Polenta, D. Prêle, R. Puddu, D. Rambaud, E. Rasztocky, P. Ringegni, G. E. Romero, J. M. Salum, C. Scóccola, A. Schillaci, S. Scully, S. Spinelli, G. Stankowiak, M. Stolpovskiy, A. D. Supanitsky, J. -P. Thermeau, P. Timbie, M. Tomasi, G. Tucker, C. Tucker, N. Vittorio, F. Wicek, M. Wright, and A. Zullo, Cavaliere, F, Mennella, A, Zannoni, M, Battaglia, P, Battistelli, E, De Bernardis, P, Burke, D, D'Alessandro, G, De Petris, M, Franceschet, C, Grandsire, L, Hamilton, J, Maffei, B, Manzan, B, Marnieros, S, Masi, S, O'Sullivan, C, Passerini, A, Pezzotta, F, Piat, M, Tartari, A, Torchinsky, S, Viganò, D, Voisin, F, Ade, P, Alberro, J, Almela, A, Amico, G, Arnaldi, L, Auguste, D, Aumont, J, Azzoni, S, Banfi, S, Baù, A, Bélier, B, Bennett, D, Bergé, L, Bernard, J, Bersanelli, M, Bigot-Sazy, M, Bonaparte, J, Bonis, J, Bunn, E, Buzi, D, Chanial, P, Chapron, C, Charlassier, R, Cobos Cerutti, A, Columbro, F, Coppolecchia, A, De Gasperis, G, De Leo, M, Dheilly, S, Duca, C, Dumoulin, L, Etchegoyen, A, Fasciszewski, A, Ferreyro, L, Fracchia, D, Gamboa Lerena, M, Ganga, K, García, B, García Redondo, M, Gaspard, M, Gayer, D, Gervasi, M, Giard, M, Gilles, V, Giraud-Heraud, Y, Gómez Berisso, M, González, M, Gradziel, M, Hampel, M, Harari, D, Henrot-Versillé, S, Incardona, F, Jules, E, Kaplan, J, Kristukat, C, Lamagna, L, Loucatos, S, Louis, T, Marty, W, Mattei, A, May, A, Mcculloch, M, Mele, L, Melo, D, Montier, L, Mousset, L, Mundo, L, Murphy, J, Nati, F, Olivieri, E, Oriol, C, Paiella, A, Pajot, F, Pastoriza, H, Pelosi, A, AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Observatoire de Paris - Site de Paris (OP), Centre National de la Recherche Scientifique (CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS), Institut de recherche en astrophysique et planétologie (IRAP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Centre de Nanosciences et de Nanotechnologies [Orsay] (C2N), Université Paris-Sud - Paris 11 (UP11)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), QUBIC, D’Alessandro, G, de Bernardis, P, Manzan, E, O’Sullivan, C, Pagana, E, Perbost, C, Perciballi, M, Piacentini, F, Piccirillo, L, Pisano, G, Platino, M, Polenta, G, Prêle, D, Puddu, R, Rambaud, D, Rasztocky, E, Ringegni, P, Romero, G, Salum, J, Scóccola, C, Schillaci, A, Scully, S, Spinelli, S, Stankowiak, G, Stolpovskiy, M, Supanitsky, A, Thermeau, J, Timbie, P, Tomasi, M, Tucker, G, Tucker, C, Vittorio, N, Wicek, F, Wright, M, and Zullo, A
Subjects: CMBR polarisation, Physics - Instrumentation and Detectors, Manchester Cancer Research Centre, Settore FIS/05, ResearchInstitutes_Networks_Beacons/mcrc, FOS: Physical sciences, Astronomy and Astrophysics, Instrumentation and Detectors (physics.ins-det), CMBR detectors, CMBR experiments, gravitational waves and CMBR polarization, FIS/05 - ASTRONOMIA E ASTROFISICA, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], CMBR experiment, Astrophysics - Instrumentation and Methods for Astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM), CMBR detector
Abstract: We present the design, manufacturing and performance of the horn-switch system developed for the technological demonstrator of QUBIC (the $Q$\&$U$ Bolometric Interferometer for Cosmology). This system is constituted of 64 back-to-back dual-band (150\,GHz and 220\,GHz) corrugated feed-horns interspersed with mechanical switches used to select desired baselines during the instrument self-calibration. We manufactured the horns in aluminum platelets milled by photo-chemical etching and mechanically tightened with screws. The switches are based on steel blades that open and close the wave-guide between the back-to-back horns and are operated by miniaturized electromagnets. We also show the current development status of the feedhorn-switch system for the QUBIC full instrument, based on an array of 400 horn-switch assemblies., 30 pages, 28 figures. Accepted for submission to JCAP
Published: 2022

43. Glasses and aging: A Statistical Mechanics Perspective

Author: Arceri, Francesco, Landes, François, Berthier, Ludovic, Biroli, Giulio, Department of Physics, University of Oregon, Université Paris-Sud - Paris 11 - Faculté des Sciences (UP11 UFR Sciences), Université Paris-Sud - Paris 11 (UP11), Laboratoire de Recherche en Informatique (LRI), CentraleSupélec-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), TAckling the Underspecified (TAU), Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire Interdisciplinaire des Sciences du Numérique (LISN), Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-CentraleSupélec-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Laboratoire Charles Coulomb (L2C), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), University of Cambridge [UK] (CAM), Systèmes Désordonnés et Applications, Laboratoire de physique de l'ENS - ENS Paris (LPENS), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Département de Physique de l'ENS-PSL, École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Département de Physique de l'ENS-PSL, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), and We thank all the collaborators who worked with us on glass physics. This work was supported by a grant from the Simons Foundation (Grant No. 454933, L. B., Grant No. 454935, G. B.)
Subjects: Condensed Matter::Soft Condensed Matter, [PHYS.COND.CM-DS-NN]Physics [physics]/Condensed Matter [cond-mat]/Disordered Systems and Neural Networks [cond-mat.dis-nn], Condensed Matter::Disordered Systems and Neural Networks, [PHYS.COND.CM-SCM]Physics [physics]/Condensed Matter [cond-mat]/Soft Condensed Matter [cond-mat.soft]
Abstract: 50 pages, 24 figs. This is an updated version of a chapter initially written in 2009 for the Encyclopedia of Complexity and Systems Science (Springer); International audience; We review the field of the glass transition, glassy dynamics and aging from a statistical mechanics perspective. We give a brief introduction to the subject and explain the main phenomenology encountered in glassy systems, with a particular emphasis on spatially heterogeneous dynamics. We review the main theoretical approaches currently available to account for these glassy phenomena, including recent developments regarding mean-field theory of liquids and glasses, novel computational tools, and connections to the jamming transition. Finally, the physics of aging and off-equilibrium dynamics exhibited by glassy materials is discussed.
Published: 2022

44. Absence Agents: Mitigating Interruptions in Extended Reality Remote Collaboration

Author: Huyen Nguyen, Thomas Bruhn, Christian Sandor, Patrick Bourdot, VENISE - Virtual & augmented ENvIronments for Simulation & Experiments, Laboratoire d'Informatique pour la Mécanique et les Sciences de l'Ingénieur (LIMSI), Université Paris-Sud - Paris 11 (UP11)-Sorbonne Université - UFR d'Ingénierie (UFR 919), Sorbonne Université (SU)-Sorbonne Université (SU)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université Paris Saclay (COmUE)-Université Paris-Sud - Paris 11 (UP11)-Sorbonne Université - UFR d'Ingénierie (UFR 919), Sorbonne Université (SU)-Sorbonne Université (SU)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université Paris Saclay (COmUE), Virtual & augmented ENvIronments for Simulation & Experiments (VENISE ), Laboratoire Interdisciplinaire des Sciences du Numérique (LISN), Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Interaction avec l'Humain (IaH), Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Virtual & augmented ENvIronments for Simulation & Experiments (VENISE), Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), and Technical University of Berlin / Technische Universität Berlin (TU)
Subjects: [INFO.INFO-HC]Computer Science [cs]/Human-Computer Interaction [cs.HC], [INFO.INFO-GR]Computer Science [cs]/Graphics [cs.GR]
Abstract: International audience; Although dealing with interruptions in remote collaboration has been studied in general, few works have done this for Extended Reality (XR) collaboration. With the current explosion of interest in XR collaboration, we explore the negative impacts of interruptions in synchronous distributed XR environments and propose a novel concept for dealing with them: Absence Agents. We present their requirements analysis, design, and a prototype implementation. We believe that our concept and design of Absence Agents are important for practitioners and researchers alike, as they highlight avenues for future research.
Published: 2022

45. Random cographs: Brownian graphon limit and asymptotic degree distribution

Author: Frédérique Bassino, Lucas Gerin, Valentin Féray, Adeline Pierrot, Mathilde Bouvel, Mickaël Maazoun, University of Zurich, Féray, Valentin, Laboratoire d'Informatique de Paris-Nord (LIPN), Université Sorbonne Paris Cité (USPC)-Institut Galilée-Université Paris 13 (UP13)-Centre National de la Recherche Scientifique (CNRS), Institut für Mathematik [Zürich], Universität Zürich [Zürich] = University of Zurich (UZH), Designing the Future of Computational Models (MOCQUA), Inria Nancy - Grand Est, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Department of Formal Methods (LORIA - FM), Laboratoire Lorrain de Recherche en Informatique et ses Applications (LORIA), Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire Lorrain de Recherche en Informatique et ses Applications (LORIA), Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL), Institut Élie Cartan de Lorraine (IECL), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Centre de Mathématiques Appliquées - Ecole Polytechnique (CMAP), École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Unité de Mathématiques Pures et Appliquées (UMPA-ENSL), Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Lyon (ENS Lyon), Bioinformatique (LRI) (BioInfo - LRI), Laboratoire de Recherche en Informatique (LRI), Université Paris-Sud - Paris 11 (UP11)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS), Swiss National Science Foundation, undergrant number 200021-17253, ANR-14-CE25-0014,GRAAL,GRaphes et Arbres ALéatoires(2014), Centre National de la Recherche Scientifique (CNRS)-Université Sorbonne Paris Nord, Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire Lorrain de Recherche en Informatique et ses Applications (LORIA), Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), École normale supérieure de Lyon (ENS de Lyon)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Interdisciplinaire des Sciences du Numérique (LISN), and Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)
Subjects: General Mathematics, Computer Graphics and Computer, Asymptotic distribution, 340 Law, 610 Medicine & health, 0102 computer and information sciences, 01 natural sciences, 1704 Computer Graphics and Computer-Aided Design, Combinatorics, 510 Mathematics, 2604 Applied Mathematics, Computer Science::Discrete Mathematics, [MATH.MATH-CO]Mathematics [math]/Combinatorics [math.CO], FOS: Mathematics, Mathematics - Combinatorics, Cograph, Aided Design, 0101 mathematics, Brownian motion, Mathematics, 2600 General Mathematics, Lebesgue measure, Degree (graph theory), Applied Mathematics, Probability (math.PR), 010102 general mathematics, Brownian excursion, Degree distribution, Computer Graphics and Computer-Aided Design, Vertex (geometry), [MATH.MATH-PR]Mathematics [math]/Probability [math.PR], 1712 Software, 10123 Institute of Mathematics, 010201 computation theory & mathematics, Combinatorics (math.CO), Mathematics - Probability, Software
Abstract: We consider uniform random cographs (either labeled or unlabeled) of large size. Our first main result is the convergence towards a Brownian limiting object in the space of graphons. We then show that the degree of a uniform random vertex in a uniform cograph is of order $n$, and converges after normalization to the Lebesgue measure on $[0,1]$. We finally analyze the vertex connectivity (i.e. the minimal number of vertices whose removal disconnects the graph) of random connected cographs, and show that this statistics converges in distribution without renormalization. Unlike for the graphon limit and for the degree of a random vertex, the limiting distribution is different in the labeled and unlabeled settings. Our proofs rely on the classical encoding of cographs via cotrees. We then use mainly combinatorial arguments, including the symbolic method and singularity analysis., 36 pages, 6 figures; v3 includes a new reference to Diaconis-Holmes-Janson (arXiv:0908.2448) for the continuity of the degree distribution for graphons
Published: 2022

46. A new role of glutathione peroxidase 4 during human erythroblast enucleation

Author: Yohann Demont, Delphine Lebon, Roggiero Lopes Dos Santos, Pascal Vong, Hakim Ouled-Haddou, Nicolas Jankovsky, Julien Demagny, Candice Carola, Jessica Platon, Alexis Caulier, Jacques Rochette, Nicolas Guillaume, Jean-Pierre Marolleau, Kahia Messaoudi, Loïc Garçon, HEMATIM - Hématopoïèse et immunologie - UR UPJV 4666 (HEMATIM), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie-Institut National de la Santé et de la Recherche Médicale (INSERM), Hématopoïèse normale et pathologique, Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris-Sud - Paris 11 (UP11), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), Service d'Oncologie Médicale [Institut Hospitalier Franco-Britannique], Division of Medical Oncology - Institut Hospitalier Franco-Britannique, CHU Amiens-Picardie, Hôpital Claude Huriez [Lille], CHU Lille, Service d'hématologie biologique, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Laboratoire d'Hématologie [CHU Amiens], and DESSAIVRE, Louise
Subjects: 0301 basic medicine, Erythroblasts, [SDV]Life Sciences [q-bio], Membrane lipids, Immunology, Cell, Enucleation, GPX4, medicine.disease_cause, Biochemistry, Filipin, Cell membrane, Mice, 03 medical and health sciences, chemistry.chemical_compound, Red Cells, Iron, and Erythropoiesis, 0302 clinical medicine, Reticulocyte, Erythroblast, medicine, Animals, Ferroptosis, Humans, Erythropoiesis, Lipid raft, chemistry.chemical_classification, Chemistry, Glutathione peroxidase, Cholera toxin, Cell Biology, Hematology, Phospholipid Hydroperoxide Glutathione Peroxidase, Cell biology, [SDV] Life Sciences [q-bio], medicine.anatomical_structure, 030104 developmental biology, 030220 oncology & carcinogenesis, lipids (amino acids, peptides, and proteins), Selenoprotein, 030215 immunology
Abstract: The Gluthation peroxidase (GPX) enzymes are part of the protective system against lipid peroxydation that includes prevention of oxydation and reduction of already oxidized lipid through enzymatic reactions catalyzed by GSH. GPX4 is one of the five GPX able to incorporate selenium. It is also the only GPX able to directly reduce in the membrane the oxidized fatty acids and cholesterol. Recent reports identified GPX4 as the central inhibitor of ferroptosis, a process during which iron-induced peroxydation of membrane lipids causes a specific cell death that can be reverted by lipophilic antioxydants or by iron chelators. GPX4 has recently been involved during mice erythropoiesis: GPX4-/-mice present a hemolytic anemia and a high apoptotic rate in spleen erythroid progenitors. Although transcriptomics and proteomics found it expressed in human erythroid precursors, its role during human erythropoiesis has not been described. Using an in-vitroerythroid differentiation protocol from CD34+cells obtained from apheresis, we confirmed that GPX4 expression was induced at RNA and protein level during differentiation. RSL3, a specific GPX4 inhibitor, didn't affect early steps of erythropoiesis (i.eclonogenic potential and progenitor amplification) nor the early maturation of erythroid precursors (assessed by sequential CD49d/CD235/CD71 staining) but led to a significant decrease in the enucleation rate as assessed by Hoechst staining using flow cytometry (74%±9 DMSO versus 35%±6 RSL3, p Using Western Blot, we observed that RSL3 exposure induced a strong GPX4 depletion in erythroid progenitors while it didn't affect GPX1, another member of the GPX family expressed in erythroid cells. In order to confirm that enucleation defect was related to GPX4 knockdown, we used an Sh-RNA strategy that allowed a 62%±6 GPX4 decrease at RNA level and a 46%±5 at protein level. We observed a significant defect in terminal enucleation in the cells transduced with shGPX4-lentiviruses in comparison with sh-Scramble (59%±5 Sh-Scr versus 39%±6 Sh-Gpx4, p We investigated then whether GPX4-knock-down affected quantitatively or qualitatively the membrane lipid content, which was shown to be involved in the enucleation process. Addition of Cholesterol to RSL3 in the medium partially restored the enucleation rate. However, lipidomics failed to show any significant difference in the total membrane lipid content (and particularly in the cholesterol content) after RSL3 exposure in comparison to DMSO. Since cholesterol is particularly abundant in the lipid rafts, we investigated whether the lipid distribution was qualitatively altered within the cell membrane. We observed a disruption of membrane lipid rafts when cells were exposed to RSL3, as shown by a 60%±12 decrease in the mean cholera toxin fluorescence intensity. GPX4 presence in lipid rafts was confirmed using immunofluorescence showing their co-localization at cell surface in human primary erythroblasts. Since lipid rafts play a role in the contractile ring that separates pyrenocyte from reticulocyte, we evaluated the myosin-light chain phosphorylation using flow cytometry and Western Blot and found it drastically decreased in GPX4-knockdown conditions. In summary, we identified GPX4 as a new actor of human terminal erythroid differentiation, independently to its function in ferroptosis control. We described its interaction at cell surface with lipid rafts that are required for the assembly of the contractile ring and cytokinesis leading to the nucleus extrusion. Disclosures No relevant conflicts of interest to declare.
Published: 2020

47. Development and evaluation of an adapted physical activity program in anorexia nervosa inpatients: A pilot study

Author: Lilian Fautrelle, Estelle Molina, Laurence Kern, Amandine Peguet, Laura Tailhardat, Renault de Tournemire, Yannick Morvan, N. Godart, Melissa Rizk, Lama Mattar, Clinique, Psychanalyse, Développement (CliPsyD), Université Paris Nanterre (UPN), Laboratoire Interdisciplinaire en Neurosciences, Physiologie et psychologie (LINP2), Institut de psychiatrie et neurosciences de Paris (IPNP - U1266 Inserm), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Groupement de recherche en Psychiatrie (GDR Psychiatrie (3557)), Centre National de la Recherche Scientifique (CNRS), Department of Natural Sciences [Lebanese American University] (NS/SAS/LAU), School of Arts and Sciences [Lebanese American University] (SAS/LAU), Lebanese American University (LAU)-Lebanese American University (LAU), CHI Poissy-Saint-Germain, Clinique Médico-Universitaire Georges Heuyer, Institut Mutualiste de Montsouris (IMM), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil (UVSQ Santé), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Institut national universitaire Champollion [Albi] (INUC), Université Fédérale Toulouse Midi-Pyrénées, The authors thank the Institut Mutualiste Montsouris, the Poissy paediatric hospital teams, and the inpatients who took part in this research., Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)
Subjects: Adult, 050103 clinical psychology, medicine.medical_specialty, Anorexia Nervosa, Adolescent, Therapeutic treatment, adapted physical activity program, Physical activity, Pilot Projects, Context (language use), Anorexia nervosa, Young Adult, 03 medical and health sciences, 0302 clinical medicine, mental disorders, Humans, Medicine, 0501 psychology and cognitive sciences, Exercise, Inpatients, business.industry, [SCCO.NEUR]Cognitive science/Neuroscience, 05 social sciences, Physical health, medicine.disease, problematic physical activity, 3. Good health, 030227 psychiatry, Open study, Psychiatry and Mental health, Clinical Psychology, Eating disorders, Physical therapy, Female, business, Body mass index
Abstract: International audience; Background and context: Problematic use of physical activity is frequent in subjects with anorexia nervosa (AN). Although it increases resistance to therapeutic treatment, paradoxically, physical activity in AN can also improve mental and physical health. Based on the literature review we hypothesized that adding an adapted physical activity (APA) program to treatment programs could be more beneficial than a total suppression of physical activities. We designed this open study to evaluate the outcome of AN inpatients after an APA program implementation as well as the perceived effect of APA. Method: Forty-one women with AN (17.2 (±2.5) years old, BMI of 16.86 (±2.0)) were included. An eight-session (1 h30/session/week) standardized APA program was delivered and evaluated by structured questionnaires assessing exercise dependence, perceived physical activity, eating disorder (ED) symptoms, body mass index (BMI), along with an interview before and after the APA program. Results: Twenty-nine women complete the PA program and evaluation. BMI and perceived PA score significantly increased, ED and exercise dependence scores significantly decreased (p
Published: 2020

48. Umbilical cord arterial and venous gases, ionogram, and glucose level for predicting neonatal morbidity at term

Author: Louise Ghesquiere, Charles Garabedian, Thameur Rakza, Véronique Houfflin-Debarge, Laurent Storme, Valérie Deken, Roxane Vanspranghels, Patrice Maboudou, Neuroimagerie en psychiatrie (U1000), Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Lille, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Descartes - Paris 5 (UPD5)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Sud - Paris 11 (UP11), and CCSD, Accord Elsevier
Subjects: medicine.medical_specialty, [SDV]Life Sciences [q-bio], Umbilical cord, Umbilical Cord, 03 medical and health sciences, 0302 clinical medicine, 030225 pediatrics, Internal medicine, medicine, Humans, Arterial pH, Gas analysis, Retrospective Studies, 030219 obstetrics & reproductive medicine, business.industry, Ionogram, Infant, Newborn, Area under the curve, Obstetrics and Gynecology, Retrospective cohort study, Hydrogen-Ion Concentration, Fetal Blood, 3. Good health, [SDV] Life Sciences [q-bio], Neonatal morbidity, Glucose, medicine.anatomical_structure, Reproductive Medicine, Cord blood, Cardiology, Gases, business
Abstract: Objective To determine which parameter of umbilical arterial cord gas analysis, pH, base deficit, lactate concentration, ionogram values, or glucose level index is the best predictor of neonatal morbidity at term. Design We conducted a 15-month retrospective cohort study that included all nonanomalous, singleton, term births at a single center. The predictive ability of lactate concentration, base deficit, pH, ionogram values, and glucose level were compared using receiver-operating characteristic curves for global and neurological composite morbidity. Optimal cutoff values for lactate concentration, base deficit, and pH were estimated based on their maximum area under the curve. Results We included 5161 newborns: 52 (1.01 %) had global composite morbidity, and 17 had (0.33 %) neurological composite morbidity. Blood levels of potassium, calcium, natremia, glucose level, and HCO3− did not differ significantly between groups. pH, partial pressure of CO2, partial pressure of O2, base deficit, and lactate levels differed significantly between neonates in the groups with and without global composite morbidity. Nearly similar results were found for neurological composite morbidity. The predictive ability did not differ between arterial pH and arterial lactate concentration (P = .25) and base deficit (P = .79). Optimal cutoff values to predict global composite morbidity were arterial pH 7.144, venous pH 7.236, and arterial lactate concentration 6.5 mmol/L. Conclusions Acid–base status analysis remains the best objective indicator for predicting neonatal morbidity and can be estimated using pH, lactate, or base deficit. Ionogram cord blood composition and glucose level do not appear to be useful for this purpose.
Published: 2020

49. A Germline Variant at 8q24 Contributes to Familial Clustering of Prostate Cancer in Men of African Ancestry

Author: Luc Multigner, William J. Blot, Alexander Lubwama, Stephen Watya, Peter E. Clark, Lucy Xia, Sara S. Strom, Adam S. Kibel, Jong Y. Park, Adam B. Murphy, Jennifer Cullen, Christopher A. Haiman, Florence Menegaux, Shiv Srivastava, Loreall Pooler, Mariana C. Stern, Anand P. Chokkalingam, Eric A. Klein, Wei Zheng, Thomas A. Sellers, Anselm Hennis, Dana C. Crawford, James L. Mohler, Jack A. Taylor, Esther M. John, Robin J. Leach, Sonja I. Berndt, Laurent Brureau, John D. Carpten, Susan Gundell, David V. Conti, Barbara Nemesure, Rosalind A. Eeles, Graham Casey, Pascal Blanchet, Benjamin A. Rybicki, Chad D. Huff, Maureen Sanderson, Stephen J. Chanock, Melinda C. Aldrich, Jay H. Fowke, Jennifer J. Hu, Diptasri Mandal, Sue A. Ingles, Kosj Yamoah, Kathleen A. Cooney, K. Govindasami, Ian M. Thompson, Patrick C. Walsh, Xin Sheng, Zsofia Kote-Jarai, Janet L. Stanford, Marie-Élise Parent, Christine Neslund-Dudas, Jianfeng Xu, William S. Bush, Phyllis J. Goodman, Meredith Yeager, Burcu F. Darst, Gary J. Smith, Victoria L. Stevens, Rick A. Kittles, Elaine A. Ostrander, Olivier Cussenot, Gyorgy Petrovics, Elizabeth T. H. Fontham, William B. Isaacs, Peggy Wan, Geraldine Cancel-Tassin, Susan M. Gapstur, Bettina F. Drake, Jeannette T. Bensen, University of Southern California (USC), Centre de Recherche pour les Pathologies Prostatiques. (CeRePP / UA 3104), CEREPP, CHU Tenon [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), CHU Pointe-à-Pitre/Abymes [Guadeloupe], U19 CA148537, U19 CA214253, R01 CA165862, and K99 CA246063, National Cancer Institute at the National Institutes of Health, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: Male, Oncology, medicine.medical_specialty, Urology, Family history, Population, 030232 urology & nephrology, Black People, Familial prostate cancer, [SDV.CAN]Life Sciences [q-bio]/Cancer, Familial clustering, Risk Assessment, Article, Germline, 03 medical and health sciences, Prostate cancer, 0302 clinical medicine, Internal medicine, Genetics, Humans, Medicine, education, Genetic variant, Aged, education.field_of_study, business.industry, Genetic Variation, Prostatic Neoplasms, 8q24, Middle Aged, medicine.disease, Health equity, 3. Good health, Disease Hotspot, Germ Cells, Prostate cancer screening, African ancestry, 030220 oncology & carcinogenesis, Health disparities, business
Abstract: International audience; Although men of African ancestry have a high risk of prostate cancer (PCa), no genes or mutations have been identified that contribute to familial clustering of PCa in this population. We investigated whether the African ancestry-specific PCa risk variant at 8q24, rs72725854, is enriched in men with a PCa family history in 9052 cases, 143 cases from high-risk families, and 8595 controls of African ancestry. We found the risk allele to be significantly associated with earlier age at diagnosis, more aggressive disease, and enriched in men with a PCa family history (32% of high-risk familial cases carried the variant vs 23% of cases without a family history and 12% of controls). For cases with two or more first-degree relatives with PCa who had at least one family member diagnosed at age
Published: 2020

50. Associations of Hemoglobin Levels With Health-Related Quality of Life, Physical Activity, and Clinical Outcomes in Persons With Stage 3-5 Nondialysis CKD

Author: Junichi Hoshino, Daniel Muenz, Jarcy Zee, Nidhi Sukul, Elodie Speyer, Murilo Guedes, Antonio A. Lopes, Koichi Asahi, Heleen van Haalen, Glen James, Nafeesa Dhalwani, Roberto Pecoits-Filho, Brian Bieber, Bruce M. Robinson, Ronald L. Pisoni, Antonio Lopes, Christian Combe, Christian Jacquelinet, Ziad Massy, Benedicte Stengel, Johannes Duttlinger, Danilo Fliser, Gerhard Lonnemann, Helmut Reichel, Takashi Wada, Kunihiro Yamagata, Ron Pisoni, Bruce Robinson, Viviane Calice da Silva, Ricardo Sesso, Ichiei Narita, Rachel Perlman, Friedrich Port, Michelle Wong, Eric Young, Toranomon Hospital [Tokyo, Japan], Arbor Research Collaborative for Health, University of Michigan [Ann Arbor], University of Michigan System, Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Pontifícia Universidade Católica do Paraná, Fukushima Medical University, AstraZeneca, Gothenburg, Sweden, AstraZeneca [Cambridge, UK], Evidera, Federal University of Bahia School of Medicine, AstraZeneca, Support: This work, produced by CKDopps as part of the Dialysis Outcomes and Practice Patterns Study (DOPPS) Program, has been supported by specific funding from AstraZeneca . To see all funding for the DOPPS Program, please visit dopps.org . All support is provided without restrictions on publications., Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), and HAL UVSQ, Équipe
Subjects: Male, 0301 basic medicine, medicine.medical_specialty, Anemia, [SDV]Life Sciences [q-bio], 030232 urology & nephrology, Physical activity, Medicine (miscellaneous), Renal function, urologic and male genital diseases, Cohort Studies, Hemoglobins, 03 medical and health sciences, 0302 clinical medicine, Quality of life, hemic and lymphatic diseases, Internal medicine, medicine, Humans, Prospective Studies, Renal Insufficiency, Chronic, Stage (cooking), Exercise, Aged, 030109 nutrition & dietetics, Nutrition and Dietetics, business.industry, Confounding, Guideline, medicine.disease, United States, female genital diseases and pregnancy complications, 3. Good health, [SDV] Life Sciences [q-bio], Nephrology, Disease Progression, Quality of Life, Female, business, Brazil, Kidney disease
Abstract: International audience; Objective: Conflicting findings and knowledge gaps exist regarding links between anemia, physical activity, health-related quality of life (HRQOL), chronic kidney disease (CKD) progression, and mortality in moderate-to-advanced CKD. Using the CKD Outcomes and Practice Patterns Study, we report associations of hemoglobin (Hgb) with HRQOL and physical activity, and associations of Hgb and physical activity with CKD progression and mortality in stage 3-5 nondialysis (ND)-CKD patients. Design and Methods: Prospectively collected data were analyzed from 2,121 ND-CKD stage 3-5 patients, aged ≥18 years, at 43 nephrologist-run US and Brazil CKD Outcomes and Practice Patterns Study–participating clinics. Cross-sectional associations were assessed of Hgb levels with HRQOL and physical activity levels (from validated Kidney Disease Quality of Life Instrument and Rapid Assessment of Physical Activity surveys). CKD progression (first of ≥40% estimated glomerular filtration rate [eGFR] decline, eGFR12 g/dL. Odds of being highly physically active were substantially greater at Hgb>10.5 g/dL. Lower Hgb was strongly associated with greater CKD progression and mortality, even after extensive adjustment. Physical inactivity was strongly associated with greater mortality and weakly associated with CKD progression. Possible residual confounding is a limitation. Conclusion: This multicenter international study provides real-world observational evidence for greater HRQOL, physical activity, lower CKD progression, and greater survival in ND-CKD patients with Hgb levels >12 g/dL, exceeding current treatment guideline recommendations. These findings help inform future studies aimed at understanding the impact of new anemia therapies and physical activity regimens on improving particular dimensions of ND-CKD patient well-being and clinical outcomes.
Published: 2020

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