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1,270 results on '"Università degli studi di Torino = University of Turin (UNITO)"'

1. The evolving role of neurosurgery for central nervous system metastases in the era of personalized cancer therapy

Author: Philipp Karschnia, Joerg-Christian Tonn, Louisa von Baumgarten, Manfred Westphal, Michael Weller, Stefan Grau, Michael A. Vogelbaum, Emilie Le Rhun, Martin J. van den Bent, Riccardo Soffietti, Matthias Preusser, Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U 1192 (PRISM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), University hospital of Zurich [Zurich], University of South Florida [Tampa] (USF), Erasmus University Medical Center [Rotterdam] (Erasmus MC), Ludwig-Maximilians-Universität München (LMU), Medizinische Universität Wien = Medical University of Vienna, Università degli studi di Torino = University of Turin (UNITO), Ludwig-Maximilians University [Munich] (LMU), Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg] (UKE), Ludwig Maximilian University [Munich] (LMU), INSERM, Université de Lille, 309388|||University hospital of Zurich [Zurich], University of South Florida [Tampa] [USF], Erasmus University Medical Center [Rotterdam] [Erasmus MC], Ludwig-Maximilians-Universität München [LMU], Università degli studi di Torino = University of Turin [UNITO], Ludwig-Maximilians University [Munich] [LMU], Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg] [UKE], Ludwig Maximilian University [Munich] [LMU], University of Zurich, and Tonn, Joerg-Christian
Subjects: Quality of life, Cancer Research, medicine.medical_specialty, Cerebral, medicine.medical_treatment, [SDV]Life Sciences [q-bio], Clinical Decision-Making, Antineoplastic Agents, 610 Medicine & health, Neurosurgical Procedures, Radiosurgery, Metastasis, Central Nervous System Neoplasms, CNS, Neurological surgery, 10180 Clinic for Neurosurgery, SDG 3 - Good Health and Well-being, Biomarkers, Tumor, medicine, Animals, Humans, 1306 Cancer Research, Molecular Targeted Therapy, Precision Medicine, Intensive care medicine, business.industry, Metastasectomy, Immunotherapy, medicine.disease, Penetrance, Hydrocephalus, 10040 Clinic for Neurology, Clinical trial, Treatment Outcome, Oncology, Chemotherapy, Adjuvant, 2730 Oncology, Neurosurgery, business, Signal Transduction
Abstract: International audience; Recent therapeutic advances involving the use of systemic targeted treatments and immunotherapeutic agents in patients with advanced cancers have translated into improved survival rates. Despite the emergence of such promising pharmacological therapies and extended survival, the frequency of metastases in the central nervous system has steadily increased. Effective medical and surgical therapies are available for many patients with brain metastases and need to be incorporated into multi-disciplinary care protocols. The role of neurosurgeons is evolving within these multi-disciplinary care teams. Surgical resection of brain metastases can provide immediate relief from neurological symptoms due to large lesions and provides the histopathological diagnosis in cases of no known primary malignancy. In situations where immunotherapy is part of the oncological treatment plan, surgery may be proposed for expeditious relief of edema to remove the need for steroids. In patients with multiple brain metastases and mixed response to therapeutics or radiosurgery, tumour resampling allows tissue analysis for druggable targets or to distinguish radiation effects from progression. Ventriculo-peritoneal shunting may improve quality of life in patients with hydrocephalus associated with leptomeningeal tumour dissemination and may allow for time to administer more therapy thus prolonging overall survival. Addressing the limited efficacy of many oncological drugs for brain metastases due to insufficient blood-brain barrier penetrance, clinical trial protocols in which surgical specimens are analysed after pre-surgical administration of therapeutics offer pharmacodynamic insights. Comprehensive neurosurgical assessment remains an integral element of multi-disciplinary oncological care of patients with brain metastases and is integral to tumour biology research and therapeutic advancement.
Published: 2021

2. EANO guideline on the diagnosis and management of meningiomas

Author: Christian Mawrin, Felix Sahm, Emilie Le Rhun, Michael D. Jenkinson, Emanuel Houdart, Florence Lefranc, Michael Weller, Pantelis Stavrinou, Morten Lund-Johansen, David Nieuwenhuizen, Riccardo Soffietti, Kita Sallabanda, Giuseppe Minniti, Roland Goldbrunner, Matthias Preusser, Ghazaleh Tabatabai, Damien C. Weber, University of Zurich, Goldbrunner, Roland, INSERM, Université de Lille, University Hospital of Cologne [Cologne], Heidelberg University Hospital [Heidelberg], Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg] [OVGU], Paul Scherrer Institute [PSI], Medizinische Universität Wien = Medical University of Vienna, Università degli Studi di Siena = University of Siena [UNISI], Hôpital Lariboisière, University hospital of Zurich [Zurich], Università degli studi di Torino = University of Turin [UNITO], Universität Zürich [Zürich] = University of Zurich [UZH], Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg] (OVGU), Paul Scherrer Institute (PSI), Università degli Studi di Siena = University of Siena (UNISI), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Università degli studi di Torino = University of Turin (UNITO), and Universität Zürich [Zürich] = University of Zurich (UZH)
Subjects: Vascular Endothelial Growth Factor A, Cancer Research, medicine.medical_specialty, medicine.medical_treatment, [SDV]Life Sciences [q-bio], 610 Medicine & health, Guidelines, meningioma, Radiosurgery, Meningioma, surgery, 10180 Clinic for Neurosurgery, Pharmacotherapy, molecular pathology, Meningeal Neoplasms, medicine, Humans, 1306 Cancer Research, Medical diagnosis, Aged, neuropathology, Molecular pathology, business.industry, radiosurgery, Guideline, medicine.disease, Magnetic Resonance Imaging, 10040 Clinic for Neurology, Clinical trial, 2728 Neurology (clinical), Oncology, Radionuclide therapy, 2730 Oncology, Neurology (clinical), Radiology, business
Abstract: Meningiomas are the most common intracranial tumors. Yet, only few controlled clinical trials have been conducted to guide clinical decision making, resulting in variations of management approaches across countries and centers. However, recent advances in molecular genetics and clinical trial results help to refine the diagnostic and therapeutic approach to meningioma. Accordingly, the European Association of Neuro-Oncology (EANO) updated its recommendations for the diagnosis and treatment of meningiomas. A provisional diagnosis of meningioma is typically made by neuroimaging, mostly magnetic resonance imaging. Such provisional diagnoses may be made incidentally. Accordingly, a significant proportion of meningiomas, notably in patients that are asymptomatic or elderly or both, may be managed by a watch-and-scan strategy. A surgical intervention with tissue, commonly with the goal of gross total resection, is required for the definitive diagnosis according to the WHO classification. A role for molecular profiling including gene panel sequencing and genomic methylation profiling is emerging. A gross total surgical resection including the involved dura is often curative. Inoperable or recurrent tumors requiring treatment can be treated with radiosurgery, if the size or the vicinity of critical structures allows that, or with fractionated radiotherapy (RT). Treatment concepts combining surgery and radiosurgery or fractionated RT are increasingly used, although there remain controversies regard timing, type, and dosing of the various RT approaches. Radionuclide therapy targeting somatostatin receptors is an experimental approach, as are all approaches of systemic pharmacotherapy. The best albeit modest results with pharmacotherapy have been obtained with bevacizumab or multikinase inhibitors targeting vascular endothelial growth factor receptor, but no standard of care systemic treatment has been yet defined.
Published: 2021

3. Prognostic factors in leptomeningeal metastases

Author: Martin J. van den Bent, Johannes Weller, Roberta Rudà, Anna S. Berghoff, P. Devos, Michael Weller, Francesca Mo, Fabian Wolpert, Dieta Brandsma, Matthias Preusser, Katharina Seystahl, Emilie Le Rhun, Anette Compter, Joost L M Jongen, Ulrich Herrlinger, Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U 1192 (PRISM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Evaluation des technologies de santé et des pratiques médicales - ULR 2694 (METRICS), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), University Hospital Bonn, Universität Zürich [Zürich] = University of Zurich (UZH), Università degli studi di Torino = University of Turin (UNITO), Antoni van Leeuwenhoek Hospital, Medizinische Universität Wien = Medical University of Vienna, Erasmus University Medical Center [Rotterdam] (Erasmus MC), INSERM, Université de Lille, Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U 1192 [PRISM], METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694, Universität Zürich [Zürich] = University of Zurich [UZH], Università degli studi di Torino = University of Turin [UNITO], Erasmus University Medical Center [Rotterdam] [Erasmus MC], University of Zurich, and Le Rhun, Emilie
Subjects: Oncology, Cancer Research, medicine.medical_specialty, business.industry, [SDV]Life Sciences [q-bio], 610 Medicine & health, Prognosis, 10040 Clinic for Neurology, 10180 Clinic for Neurosurgery, 2728 Neurology (clinical), Text mining, Internal medicine, medicine, Meningeal Neoplasms, Humans, 2730 Oncology, 1306 Cancer Research, Neurology (clinical), business, Letters to the Editor, Meningeal Carcinomatosis
Abstract: International audience; We appreciate the interest of our colleagues Dankner and Maritan in our efforts to delineate prognostic disease patterns in leptomeningeal metastasis. In their communication, they specifically address the role of prior surgery for brain metastasis in this patient population. The authors perceive a discrepancy between our findings and those of previous studies. These previous studies had reported that patients, who had surgery for brain metastases and developed leptomeningeal metastases thereafter, fared better if they had nodular disease rather than linear disease.However, what we report is that only in the absence of tumor cells in the cerebrospinal fluid (CSF), nodular disease is an indicator of inferior outcome, which likely corresponds to tumor burden driving the disease course. The previous studies1,2 report on imaging defined leptomeningeal metastases and did not distinguish patients with or without positive CSF cytology.In our cohort, a history of brain metastases prior to the diagnosis of leptomeningeal metastases was noted in 32 type II patients (defined as patients without positive CSF cytology), of whom only 11 had surgery which was combined with radiotherapy in all cases: stereotactic radiosurgery (SRS) in 5, whole brain radiotherapy (WBRT) in 5, and SRS plus WBRT in 1 patient).We understand the interest in the history of prior surgery, but to analyze these data would have been beyond the scope of our study, especially considering the small number of patients in this subgroup. Further, MRI was not centrally collected and re-reviewed, further, data on the location and distance of leptomeningeal nodules to the site of surgically approached brain metastases and the extent of resection, and surgical technique used, including potential opening of the ventricle during surgery, were not collected.Accordingly, we fully agree with the authors that further efforts at better defining risk profiles for the development of leptomeningeal metastases are needed, but we also would like to caution against underestimating the complexity of such studies, notably in a multicenter retrospective design. Heterogeneity of patients and tumors included in such studies also need to be considered. Accordingly, ideally, well-planned prospective cohort studies could try to resolve some of the important issues raised by our colleagues.
Published: 2021

4. Prognostic validation and clinical implications of the EANO ESMO classification of leptomeningeal metastasis from solid tumors

Author: Dieta Brandsma, Martin J. van den Bent, Katharina Seystahl, Emilie Le Rhun, Patrick Devos, Fabian Wolpert, Anna S. Berghoff, Matthias Preusser, Ulrich Herrlinger, Johannes Weller, Joost L M Jongen, Annette Compter, Roberta Rudà, Michael Weller, Francesca Mo, University of Zurich, Le Rhun, Emilie, Neurology, Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U 1192 (PRISM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Evaluation des technologies de santé et des pratiques médicales - ULR 2694 (METRICS), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), University Hospital Bonn, University hospital of Zurich [Zurich], Università degli studi di Torino = University of Turin (UNITO), Antoni van Leeuwenhoek Hospital, Medizinische Universität Wien = Medical University of Vienna, Erasmus University Medical Center [Rotterdam] (Erasmus MC), Universität Zürich [Zürich] = University of Zurich (UZH), INSERM, Université de Lille, Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192, METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694, Università degli studi di Torino = University of Turin [UNITO], Erasmus University Medical Center [Rotterdam] [Erasmus MC], and Universität Zürich [Zürich] = University of Zurich [UZH]
Subjects: intrathecal, Cancer Research, medicine.medical_specialty, [SDV]Life Sciences [q-bio], 610 Medicine & health, Gastroenterology, Asymptomatic, 10180 Clinic for Neurosurgery, Cerebrospinal fluid, Pharmacotherapy, SDG 3 - Good Health and Well-being, Cytology, Internal medicine, Neoplasms, medicine, Meningeal Neoplasms, cerebrospinal, Humans, fluid, meningitis, neoplastic, 1306 Cancer Research, Survival analysis, Retrospective Studies, medicine.diagnostic_test, Errata, business.industry, Magnetic resonance imaging, Prognosis, Magnetic Resonance Imaging, 10040 Clinic for Neurology, Clinical trial, Log-rank test, 2728 Neurology (clinical), Oncology, 2730 Oncology, Neurology (clinical), medicine.symptom, business, Meningeal Carcinomatosis
Abstract: Background The EANO ESMO guidelines have proposed a classification of leptomeningeal metastases (LM) from solid cancers based on clinical, magnetic resonance imaging (MRI), and cerebrospinal fluid (CSF) cytology presentation. MRI patterns are classified as linear, nodular, both, or neither. Type I LM is defined by positive CSF cytology (confirmed LM) whereas type II LM is defined by typical clinical and MRI signs (probable or possible LM). Here we explored the clinical utility of these LM subtypes. Patients and methods We retrospectively assembled data from 254 patients with newly diagnosed LM from solid tumors. Survival curves were derived using the Kaplan–Meier method and compared by Log-rank test. Results Median age at LM diagnosis was 56 years. Typical clinical LM features were noted in 225 patients (89%); 13 patients (5%) were clinically asymptomatic. Tumor cells in the CSF were observed in 186 patients (73%) whereas the CSF was equivocal in 24 patients (9.5%) and negative in 44 patients (17.5%). Patients with confirmed LM had inferior outcome compared with patients with probable or possible LM (P = 0.006). Type I patients had inferior outcome than type II patients (P = 0.002). Nodular disease on MRI was a negative prognostic factor in type II LM (P = 0.014), but not in type I LM. On multivariate analysis, administration of either intrathecal pharmacotherapy (P = 0.012) or systemic pharmacotherapy (P = 0.0003) was associated with improved outcome in type I LM, but not in type II LM. Conclusion The EANO ESMO LM subtypes are highly prognostic and should be considered for stratification and overall design of clinical trials.
Published: 2020

5. Determining medical decision-making capacity in brain tumor patients:why and how?

Author: Simon Kerrigan, Johan A F Koekkoek, Tobias Walbert, Simone Veronese, Stefan Oberndorfer, Andrea Pace, Roger Henriksson, H. Roeline W. Pasman, Jane Fleming, Helen Bulbeck, Christine Marosi, Robin Grant, Alasdair G Rooney, Michael Weller, Wolfgang Wick, Martin J B Taphoorn, Kathy Oliver, Roberta Rudà, Martin J. van den Bent, Heidrun Golla, Linda Dirven, Emilie Le Rhun, Ingela Oberg, INSERM, Université de Lille, Leiden University Medical Center [LUMC], Erasmus University Medical Center [Rotterdam] [Erasmus MC], University Hospital of Cologne [Cologne], Umeå University, Medizinische Universität Wien = Medical University of Vienna, Cambridge University Hospitals - NHS [CUH], St. Pölten University of Applied Sciences, Amsterdam University Medical Centers [Amsterdam UMC], Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192, University of Edinburgh, Università degli studi di Torino = University of Turin [UNITO], Henry Ford Health System, University hospital of Zurich [Zurich], Heidelberg University Hospital [Heidelberg], Neurology, Leiden University Medical Center (LUMC), Universiteit Leiden, Erasmus University Medical Center [Rotterdam] (Erasmus MC), Cambridge University Hospitals - NHS (CUH), University of Cambridge [UK] (CAM), Amsterdam University Medical Centers (Amsterdam UMC), Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U 1192 (PRISM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), and Università degli studi di Torino = University of Turin (UNITO)
Subjects: medicine.medical_specialty, Palliative care, [SDV]Life Sciences [q-bio], Psychological intervention, Brain tumor, Reviews, Medicine (miscellaneous), Best interests, 03 medical and health sciences, 0302 clinical medicine, neurodegenerative disease, Informed consent, brain metastases, glioma, Medicine, Intensive care medicine, Cognitive impairment, business.industry, Consent to treatment, capacity, Medical decision making, medicine.disease, 030220 oncology & carcinogenesis, consent, business, 030217 neurology & neurosurgery
Abstract: Background Brain tumor patients are at high risk of impaired medical decision-making capacity (MDC), which can be ethically challenging because it limits their ability to give informed consent to medical treatments or participation in research. The European Association of Neuro-Oncology Palliative Care Multidisciplinary Task Force performed a systematic review to identify relevant evidence with respect to MDC that could be used to give recommendations on how to cope with reduced MDC in brain tumor patients. Methods A literature search in several electronic databases was conducted up to September 2019, including studies with brain tumor and other neurological patients. Information related to the following topics was extracted: tools to measure MDC, consent to treatment or research, predictive patient- and treatment-related factors, surrogate decision making, and interventions to improve MDC. Results A total of 138 articles were deemed eligible. Several structured capacity-assessment instruments are available to aid clinical decision making. These instruments revealed a high incidence of impaired MDC both in brain tumors and other neurological diseases for treatment- and research-related decisions. Incapacity appeared to be mostly determined by the level of cognitive impairment. Surrogate decision making should be considered in case a patient lacks capacity, ensuring that the patient’s “best interests” and wishes are guaranteed. Several methods are available that may help to enhance patients’ consent capacity. Conclusions Clinical recommendations on how to detect and manage reduced MDC in brain tumor patients were formulated, reflecting among others the timing of MDC assessments, methods to enhance patients’ consent capacity, and alternative procedures, including surrogate consent.
Published: 2020

6. Transient Receptor Potential Channel Expression Signatures in Tumor-Derived Endothelial Cells: Functional Roles in Prostate Cancer Angiogenesis

Author: Bernardini, Michela, Brossa, Alessia, Chinigo, Giorgia, Grolez, Guillaume P., Trimaglio, Giulia, Allart, Laurent, Hulot, Audrey, Marot, Guillemette, Genova, Tullio, Joshi, Aditi, Mattot, Virginie, Fromont, Gaelle, Munaron, Luca, Bussolati, Benedetta, Prevarskaya, Natalia, Pla, Alessandra Fiorio, Gkika, Dimitra, Laboratoire de Physiologie Cellulaire : Canaux ioniques, inflammation et cancer - U 1003 (PHYCELL), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Molecular Biotechnology Center, Università degli studi di Torino = University of Turin (UNITO), Service de neurologie et pathologie du mouvement, Hôpital Roger Salengro [Lille]-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), BILILLE, MOdel for Data Analysis and Learning (MODAL), Laboratoire Paul Painlevé (LPP), Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université de Lille, Sciences et Technologies-Inria Lille - Nord Europe, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Evaluation des technologies de santé et des pratiques médicales - ULR 2694 (METRICS), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-École polytechnique universitaire de Lille (Polytech Lille), Dipartimento di Scienze della Vita e Biologia dei Sistemi, Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP), Nutrition, croissance et cancer (U 1069) (N2C), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Molecular Biotechnology and Health Sciences, Rôle des canaux ioniques membranaires et du calcium intracellulaire dans la physiopathologie de la prostate, Université de Lille, Sciences et Technologies-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'Anatomie et de Cytologie Pathologiques [Poitiers], Centre hospitalier universitaire de Poitiers (CHU Poitiers), Università degli studi di Torino (UNITO), Inria Lille - Nord Europe, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire Paul Painlevé - UMR 8524 (LPP), Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Evaluation des technologies de santé et des pratiques médicales - ULR 2694 (METRICS), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-École polytechnique universitaire de Lille (Polytech Lille)-Université de Lille, Sciences et Technologies, Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Turin, CHU Lille, CNRS, Inserm, Université de Lille, METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694, Mécanismes de la Tumorigénèse et Thérapies Ciblées (M3T) - UMR 8161, Physiologie Cellulaire (PHYCEL) - U1003, Physiologie Cellulaire (PHYCELL) - U1003, Santé publique : épidémiologie et qualité des soins - EA 2694, Università degli studi di Torino = University of Turin [UNITO], Laboratoire de Physiologie Cellulaire : Canaux ioniques, inflammation et cancer - U 1003 [PHYCELL], Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS], Mécanismes de la Tumorigénèse et Thérapies Ciblées - UMR 8161 [M3T], Nutrition, croissance et cancer (U 1069) [N2C], Laboratoire Paul Painlevé - UMR 8524 (LPP), Centre National de la Recherche Scientifique (CNRS)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université de Lille-Université de Lille, Sciences et Technologies-Inria Lille - Nord Europe, and Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille-École polytechnique universitaire de Lille (Polytech Lille)
Subjects: [SDV]Life Sciences [q-bio], education, TRP, calcium channel, migration, prostate cancer, tumor angiogenesis, [SDV.CAN]Life Sciences [q-bio]/Cancer, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, lcsh:RC254-282, Article
Abstract: Background: Transient receptor potential (TRP) channels control multiple processes involved in cancer progression by modulating cell proliferation, survival, invasion and intravasation, as well as, endothelial cell (EC) biology and tumor angiogenesis. Nonetheless, a complete TRP expression signature in tumor vessels, including in prostate cancer (PCa), is still lacking. Methods: In the present study, we profiled by qPCR the expression of all TRP channels in human prostate tumor-derived ECs (TECs) in comparison with TECs from breast and renal tumors. We further functionally characterized the role of the &lsquo, prostate-associated&rsquo, channels in proliferation, sprout formation and elongation, directed motility guiding, as well as in vitro and in vivo morphogenesis and angiogenesis. Results: We identified three &lsquo, genes whose expression is upregulated in prostate TECs: TRPV2 as a positive modulator of TEC proliferation, TRPC3 as an endothelial PCa cell attraction factor and TRPA1 as a critical TEC angiogenic factor in vitro and in vivo. Conclusions: We provide here the full TRP signature of PCa vascularization among which three play a profound effect on EC biology. These results contribute to explain the aggressive phenotype previously observed in PTEC and provide new putative therapeutic targets.
Published: 2019

7. Expanding the Mutation Spectrum in ABCA4: Sixty Novel Disease Causing Variants and Their Associated Phenotype in a Large French Stargardt Cohort

Author: Marco Nassisi, Christina Zeitz, Claire-Marie Dhaenens, José-Alain Sahel, Christel Condroyer, Isabelle Audo, Vanessa Démontant, Marine Foussard, Saddek Mohand-Said, Fiona Boyard, Chiara M. Eandi, Aline Antonio, Cécile Méjécase, Camille Andrieu, Institut de la Vision, Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Surgical Sciences [Turin, Italy] (Eye Clinic), University of Turin, Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts (CHNO), Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U1172 Inserm - U837 (JPArc), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Lille Nord de France (COMUE)-Université de Lille, Fondation Ophtalmologique Adolphe de Rothschild [Paris], Académie des Sciences, Institut de France, Department of Ophthalmology [Pittsburg, PA, USA], University of Pittsburgh School of Medicine, Pennsylvania Commonwealth System of Higher Education (PCSHE)-Pennsylvania Commonwealth System of Higher Education (PCSHE), CHU Lille, Inserm, Université de Lille, Université Paris-Sorbonne [UP4], Lille Neurosciences & Cognition (LilNCog) - U 1172, Università degli studi di Torino = University of Turin [UNITO], Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Università degli studi di Torino = University of Turin (UNITO), Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 (JPArc), Université Lille Nord de France (COMUE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Académie des Sciences [Paris], and HAL UPMC, Gestionnaire
Subjects: 0301 basic medicine, Male, genetic structures, ABCA4, phenotype-genotype correlation, Phenotype-genotype correlation, Stargardt disease, ATP-Binding Cassette Transporters, Adolescent, Adult, Codon, Nonsense, Cohort Studies, Computer Simulation, Electroretinography, Exons, Female, France, Heterozygote, Humans, Longitudinal Studies, Macular Degeneration, Middle Aged, Mutation, Missense, Phenotype, Stargardt Disease, Tomography, Optical Coherence, Genetic Association Studies, medicine.disease_cause, lcsh:Chemistry, Exon, 0302 clinical medicine, Medicine, Missense mutation, Tomography, lcsh:QH301-705.5, Spectroscopy, Genetics, Sanger sequencing, Mutation, biology, General Medicine, Computer Science Applications, symbols, [SDV.GEN.GH] Life Sciences [q-bio]/Genetics/Human genetics, Catalysis, Frameshift mutation, Inorganic Chemistry, 03 medical and health sciences, symbols.namesake, Physical and Theoretical Chemistry, Codon, Molecular Biology, [SDV.GEN.GPO]Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE], business.industry, Organic Chemistry, medicine.disease, eye diseases, 030104 developmental biology, Nonsense, lcsh:Biology (General), lcsh:QD1-999, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, Optical Coherence, 030221 ophthalmology & optometry, biology.protein, [SDV.GEN.GPO] Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE], Age of onset, Missense, business
Abstract: International audience; Here we report novel mutations in ABCA4 with the underlying phenotype in a large French cohort with autosomal recessive Stargardt disease. The DNA samples of 397 index subjects were analyzed in exons and flanking intronic regions of ABCA4 (NM_000350.2) by microarray analysis and direct Sanger sequencing. At the end of the screening, at least two likely pathogenic mutations were found in 302 patients (76.1%) while 95 remained unsolved: 40 (10.1%) with no variants identified, 52 (13.1%) with one heterozygous mutation, and 3 (0.7%) with at least one variant of uncertain significance (VUS). Sixty-three novel variants were identified in the cohort. Three of them were variants of uncertain significance. The other 60 mutations were classified as likely pathogenic or pathogenic, and were identified in 61 patients (15.4%). The majority of those were missense (55%) followed by frameshift and nonsense (30%), intronic (11.7%) variants, and in-frame deletions (3.3%). Only patients with variants never reported in literature were further analyzed herein. Recruited subjects underwent complete ophthalmic examination including best corrected visual acuity, kinetic and static perimetry, color vision test, full-field and multifocal electroretinography, color fundus photography, short-wavelength and near-infrared fundus autofluorescence imaging, and spectral domain optical coherence tomography. Clinical evaluation of each subject confirms the tendency that truncating mutations lead to a more severe phenotype with electroretinogram (ERG) impairment (p = 0.002) and an earlier age of onset (p = 0.037). Our study further expands the mutation spectrum in the exonic and flanking regions of ABCA4 underlying Stargardt disease.
Published: 2018

8. Steering self-organisation through confinement

Author: Araújo, Nuno A.M., Janssen, Liesbeth M.C., Barois, Thomas, Boffetta, Guido, Cohen, Itai, Corbetta, Alessandro, Dauchot, Olivier, Dijkstra, Marjolein, Durham, William M., Dussutour, Audrey, Garnier, Simon, Gelderblom, Hanneke, Golestanian, Ramin, Isa, Lucio, Koenderink, Gijsje H., Löwen, Hartmut, Metzler, Ralf, Polin, Marco, Royall, C. Patrick, Šarić, Anđela, Sengupta, Anupam, Sykes, Cécile, Trianni, Vito, Tuval, Idan, Vogel, Nicolas, Yeomans, Julia M., Zuriguel, Iker, Marin, Alvaro, Volpe, Giorgio, Sub Soft Condensed Matter, Soft Condensed Matter and Biophysics, Sub Soft Condensed Matter, Soft Condensed Matter and Biophysics, MESA+ Institute, Physics of Fluids, Universidade de Lisboa, Eindhoven University of Technology [Eindhoven] (TU/e), Laboratoire Ondes et Matière d'Aquitaine (LOMA), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Università degli studi di Torino = University of Turin (UNITO), Cornell University [New York], Laboratory of Atomic and Solid State Physics [Ithaca] (LASSP), Gulliver (UMR 7083), Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Utrecht University [Utrecht], University of Sheffield [Sheffield], Centre de Recherches sur la Cognition Animale - UMR5169 (CRCA), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Centre de Biologie Intégrative (CBI), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Toulouse Mind & Brain Institut (TMBI), Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT), New Jersey Institute of Technology [Newark] (NJIT), Max Planck Institute for Dynamics and Self-Organization (MPIDS), Max-Planck-Gesellschaft, Rudolf Peierls Centre for Theoretical Physics, University of Oxford, Department of Materials [ETH Zürich] (D-MATL), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Kavli Institute of Nanosciences [Delft] (KI-NANO), Delft University of Technology (TU Delft), Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf], University of Potsdam = Universität Potsdam, Institut Mediterrani d'Estudis Avancats (IMEDEA), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Universidad de las Islas Baleares (UIB), Institute of Science and Technology [Klosterneuburg, Austria] (IST Austria), University of Luxembourg [Luxembourg], Matière Cellulaire Active, Laboratoire de physique de l'ENS - ENS Paris (LPENS), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Département de Physique de l'ENS-PSL, École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Département de Physique de l'ENS-PSL, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Institute of Cognitive Sciences and Technologies, National Research Council of Italy (CNR) (ISTC), Universidad de Navarra [Pamplona] (UNAV), University of Twente, Department of Chemistry [University College of London], University College of London [London] (UCL), ANR-18-CE33-0006,MSR,Machines Morpho-fonctionelles en Essaim(2018), ANR-14-CE09-0006,Actin2Nucleus,Connexion mécanique entre le cytosquelette d'actine et le noyau(2014), ANR-12-BSV5-0014,Contract,Nouveaux systèmes biomimétiques pour étudier la contractilité acto-myosine cellulaire(2012), European Project: 884902,SoftML, European Project: 802960,NEPA, European Project: 955910,PHYMOT, and European Project: 678573,H2020,ERC-2015-STG,NanoPacks(2016)
Subjects: Pattern-formation, Physics - Physics and Society, Chemistry(all), [SDV]Life Sciences [q-bio], [PHYS.PHYS.PHYS-BIO-PH]Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph], Collective behavior, FOS: Physical sciences, Physics and Society (physics.soc-ph), General Chemistry, Condensed Matter - Soft Condensed Matter, Condensed Matter Physics, Nonlinear Sciences - Adaptation and Self-Organizing Systems, Particles, Biological Physics (physics.bio-ph), Information, Soft Condensed Matter (cond-mat.soft), Physics - Biological Physics, [PHYS.COND.CM-SCM]Physics [physics]/Condensed Matter [cond-mat]/Soft Condensed Matter [cond-mat.soft], Adaptation and Self-Organizing Systems (nlin.AO)
Abstract: Self-organisation is the spontaneous emergence of spatio-temporal structures and patterns from the interaction of smaller individual units. Examples are found across many scales in very different systems and scientific disciplines, from physics, materials science and robotics to biology, geophysics andastronomy. Recent research has highlighted how self-organisation can be both mediated and controlled by confinement. Confinement is an action over a system that limits its units’ translational and rotational degrees of freedom, thus also influencing the system’s phase space probability density; it can functionas either a catalyst or inhibitor of self-organisation. Confinement can then become a means to actively steer the emergence or suppression of collective phenomena in space and time. Here, to provide a common framework and perspective for future research, we examine the role of confinement in the self-organisation of soft-matter systems and identify overarching scientific challenges that need to be addressed to harness its full scientific and technological potential in soft matter and related fields.By drawing analogies with other disciplines, this framework will accelerate a common deeper understanding of self-organisation and trigger the development of innovative strategies to steer it using confinement, with impact on, e.g., the design of smarter materials, tissue engineering for biomedicineand in guiding active matter.
Published: 2023

9. Phase II study of copanlisib, a PI3K inhibitor, in relapsed or refractory, indolent or aggressive lymphoma

Author: Dominique Bron, Catherine Thieblemont, Umberto Vitolo, M Neves, Kim Linton, Martin Dreyling, Igor Gorbatchevsky, Pier Luigi Zinzani, J. Garcia-Vargas, David Cunningham, Li Liu, Carol Peña, Karl Koechert, M. Giurescu, Barrett H. Childs, Sarit Assouline, Krimo Bouabdallah, Gregor Verhoef, Florian Hiemeyer, Franck Morschhauser, Dreyling, M, Morschhauser, F, Bouabdallah, K, Bron, D, Cunningham, D, Assouline, S. E, Verhoef, G, Linton, K, Thieblemont, C, Vitolo, U, Hiemeyer, F, Giurescu, M, Garcia-Vargas, J, Gorbatchevsky, I, Liu, L, Koechert, K, Peña, C, Neves, M, Childs, B. H, Zinzani, P. L., Klinikum der Universität [München], Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 (GRITA), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), CHU Bordeaux [Bordeaux], Ecole de Santé Publique [Université Libre de Bruxelles], Université libre de Bruxelles (ULB), IBM Thomas J. Watson Research Center, IBM, Jewish General Hospital, University Hospitals Leuven [Leuven], Manchester University NHS Foundation Trust (MFT), Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Università degli studi di Torino (UNITO), Bayer Pharma AG [Berlin], Bayer HealthCare Pharmaceuticals Inc [Whippany], University of Bologna, Università degli studi di Torino = University of Turin (UNITO), University of Bologna/Università di Bologna, Université de Lille, CHU Lille, Groupe de Recherche sur les formes Injectables et les Technologies Associées (GRITA) - EA 7365, Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA], Manchester University NHS Foundation Trust [MFT], Hopital Saint-Louis [AP-HP] [AP-HP], and Università degli studi di Torino = University of Turin [UNITO]
Subjects: Male, 0301 basic medicine, Pathology, copanlisib, Lymphoma, [SDV]Life Sciences [q-bio], Follicular lymphoma, Phases of clinical research, Aggressive lymphoma, Gastroenterology, Phosphatidylinositol 3-Kinases, chemistry.chemical_compound, 0302 clinical medicine, Recurrence, Phosphoinositide-3 Kinase Inhibitors, Aged, 80 and over, Haematologic Malignancies, Manchester Cancer Research Centre, treatment, Lymphoma, Non-Hodgkin, Malignant lymphoma, Hematology, Middle Aged, Hodgkin Disease, 3. Good health, Oncology, 030220 oncology & carcinogenesis, Female, Rituximab, malignant lymphoma, medicine.drug, medicine.medical_specialty, Antineoplastic Agents, PI3K inhibitor, Neutropenia, 03 medical and health sciences, Internal medicine, Biomarkers, Tumor, medicine, Humans, Survival analysis, Aged, Copanlisib, business.industry, ResearchInstitutes_Networks_Beacons/mcrc, PTEN Phosphohydrolase, Original Articles, medicine.disease, Isoflavones, Survival Analysis, Treatment, Editor's Choice, Pyrimidines, 030104 developmental biology, chemistry, Quinazolines, business, Hématologie
Abstract: Background: Copanlisib is a pan-class I phosphatidylinositol 3-kinase inhibitor with predominant activity against the α- and δ-isoforms. Patients and methods: This phase II study evaluated the response rate of copanlisib administered intravenously on days 1, 8, and 15 of a 28-day cycle, in patients with indolent or aggressive malignant lymphoma. Archival tumor tissues were used for immunohistochemistry, gene-expression profiling, and mutation analysis. Results: Thirty-three patients with indolent lymphoma and 51 with aggressive lymphoma received copanlisib. Follicular lymphoma (48.5%) and peripheral T-cell lymphoma (33.3%) were the most common histologic subtypes. Most patients (78.6%) had received prior rituximab and 54.8% were rituximab-refractory. Median duration of treatment was 23 and 8 weeks in the indolent and aggressive cohorts, respectively (overall range 2-138). Eighty patients were evaluated for efficacy. The objective response rate was 43.7% (14/32) in the indolent cohort and 27.1% (13/48) in the aggressive cohort; median progression-free survival was 294 days (range 0-874) and 70 days (range 0-897), respectively; median duration of response was 390 days (range 0-825) and 166 days (range 0-786), respectively. Common adverse events included hyperglycemia (57.1%; grade ≥3, 23.8%), hypertension (54.8%; grade ≥3, 40.5%), and diarrhea (40.5%; grade ≥3, 4.8%), all generally manageable. Neutropenia occurred in 28.6% of patients (grade 4, 11.9%). Molecular analyses showed enhanced antitumor activity in tumors with upregulated phosphatidylinositol 3-kinase pathway gene expression. Conclusion: Intravenous copanlisib demonstrated promising efficacy and manageable toxicity in heavily pretreated patients with various subtypes of indolent and aggressive malignant lymphoma. Subtype-specific studies of copanlisib in patients with follicular, peripheral T-cell, and mantle cell lymphomas are ongoing., SCOPUS: ar.j, info:eu-repo/semantics/published
Published: 2017

10. Estimates of nectar productivity through a simulation approach differ from the nectar produced in 24 h

Author: Luca Carisio, Lucie Schurr, Véronique Masotti, Marco Porporato, Gabriel Nève, Laurence Affre, Sophie Gachet, Benoît Geslin, Università degli studi di Torino = University of Turin (UNITO), Institut méditerranéen de biodiversité et d'écologie marine et continentale (IMBE), Avignon Université (AU)-Aix Marseille Université (AMU)-Institut de recherche pour le développement [IRD] : UMR237-Centre National de la Recherche Scientifique (CNRS), Ecosystèmes, biodiversité, évolution [Rennes] (ECOBIO), Université de Rennes (UR)-Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR), Université de Rennes (UR)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS), and This research was co-funded by Pernod-Ricard France® (PRF) and the ‘Association Nationale de Recherche et Technologies’ (ANRT®)
Subjects: floral traits, nectar rewards, floral resources, insect foraging, mass-flowering crops, plant-insect interactions, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, Ecology, Evolution, Behavior and Systematics
Abstract: International audience; Nectar is a key resource for numerous insects. Despite its importance, nectar productivity has mainly been assessed using one sampling method, in which the volume of nectar produced by a flower is measured after 24 h of isolation from insects (‘measured 24 h volume’ hereafter). This method assumes that nectar removal by flower-visiting insects does not affect nectar productivity. Hence, a linearity in the nectar production dynamic is assumed. The effect of nectar removal could lead to an actual volume of nectar produced per flower over 24 h being higher or lower than the measured 24 h volume. Whether the nectar productivity is influenced by insect activity still therefore needs to be assessed. In a field experiment, we estimated the nectar production dynamics of lavender (Lavandula hybrida) and fennel (Foeniculum vulgare) flowers and tested whether they met the linearity assumption. Then, we developed a simulation model to identify how different scenarios of insect foraging activity: nectar removal rate (average and maximum), and flower-selection strategies (random selection or rewarding flower selection) alter the estimated 24 h volume of nectar for both crops (‘estimated 24 h volume’ hereafter). Finally, we tested whether the estimated 24 h volume differed from the measured 24 h volume for both crops. Lavender and fennel showed equal measured 24 h volume of nectar but the produced nectar volume over 6 h suggested that a flower of lavender was more productive than a flower of fennel. Both nectar production dynamics did not meet the assumption of linearity. The simulation models showed that the estimated 24 h volume increased with maximum nectar removal rate for lavender, and the opposite was found for fennel. Rewarding selection always increased the estimated 24 h volume for fennel while for lavender a positive effect was detected at average rate of nectar removal. We found that the estimated 24 h volume was always greater than the measured 24 h volume. Our model demonstrated that the effect of insect foraging activity on flower's nectar productivity should be considered while estimating the resources produced by plants. As an alternative, measures of produced nectar volume in short time spans may be compared with the measured 24 h volume to check the reliability of this widespread method.
Published: 2022

11. Quantitation of endogenous GnRH by validated nano-HPLC-HRMS method: a pilot study on ewe plasma

Author: Enrica Mecarelli, Riccardo Aigotti, Alberto Asteggiano, Paolo Giacobini, Manon Chasles, Yves Tillet, Federica Dal Bello, Claudio Medana, Università degli studi di Torino = University of Turin (UNITO), Lille Neurosciences & Cognition - U 1172 (LilNCog), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), CHU Lille, Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Institut Français du Cheval et de l'Equitation [Saumur] (IFCE)-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Marchoux, Eric
Subjects: [SDV.SA]Life Sciences [q-bio]/Agricultural sciences, [SDV.SA] Life Sciences [q-bio]/Agricultural sciences, Sheep, Surrogate matrix, Method validation, Pilot Projects, [SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology, Biochemistry, Analytical Chemistry, Gonadotropin-Releasing Hormone, Endogenous peptide, GnRH, Nano-HPLC-HRMS, PNA, Pregnancy, Androgens, Animals, Humans, Protein Isoforms, Female, Chromatography, High Pressure Liquid, [SDV.BDLR] Life Sciences [q-bio]/Reproductive Biology
Abstract: Gonadotropin-releasing hormone isoform I (GnRH), a neuro-deca-peptide, plays a fundamental role in development and maintenance of the reproductive system in vertebrates. The anomalous release of GnRH is observed in reproductive disorder such as hypogonadotropic hypogonadism, polycystic ovary syndrome (PCOS), or following prenatal exposure to elevated androgen levels. Quantitation of GnRH plasma levels could help to diagnose and better understand these pathologies. Here, a validated nano-high-performance liquid chromatography–high-resolution mass spectrometry (HPLC-HRMS) method to quantify GnRH in ewe plasma samples is presented. Protein precipitation and solid-phase extraction (SPE) pre-treatment steps were required to purify and enrich GnRH and internal standard (lamprey-luteinizing hormone-releasing hormone-III, l-LHRH-III). For the validation process, a surrogate matrix approach was chosen following the International Council for Harmonisation (ICH) and FDA guidelines. Before the validation study, the validation model using the surrogate matrix was compared with those using a real matrix such as human plasma. All the tested parameters were analogous confirming the use of the surrogate matrix as a standard calibration medium. From the validation study, limit of detection (LOD) and limit of quantitation (LOQ) values of 0.008 and 0.024 ng/mL were obtained, respectively. Selectivity, accuracy, precision, recovery, and matrix effect were assessed with quality control samples in human plasma and all values were acceptable. Sixteen samples belonging to healthy and prenatal androgen (PNA) exposed ewes were collected and analyzed, and the GnRH levels ranged between 0.05 and 3.26 ng/mL. The nano-HPLC-HRMS developed here was successful in measuring GnRH, representing therefore a suitable technique to quantify GnRH in ewe plasma and to detect it in other matrices and species. Graphical abstract
Published: 2022

12. Governing Agents on the Web

Author: Charpenay, Victor, Baldoni, Matteo, Ciortea, Andrei, Cranefield, Stephen, Padget, Julian, Singh, Munindar, École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT), Laboratoire d'Informatique, de Modélisation et d'Optimisation des Systèmes (LIMOS), Ecole Nationale Supérieure des Mines de St Etienne (ENSM ST-ETIENNE)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)-Institut national polytechnique Clermont Auvergne (INP Clermont Auvergne), Université Clermont Auvergne (UCA)-Université Clermont Auvergne (UCA), Institut Henri Fayol (FAYOL-ENSMSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Département Informatique et systèmes intelligents ( FAYOL-ENSMSE), Ecole Nationale Supérieure des Mines de St Etienne (ENSM ST-ETIENNE), Università degli studi di Torino = University of Turin (UNITO), University of St.Gallen (HSG), University of Otago [Dunedin, Nouvelle-Zélande], University of Bath [Bath], North Carolina State University [Raleigh] (NC State), and University of North Carolina System (UNC)
Subjects: [INFO.INFO-MA]Computer Science [cs]/Multiagent Systems [cs.MA], [INFO]Computer Science [cs]
Abstract: This paper summarizes the findings of the working group "Governance" at the Dagstuhl seminar on Agents on the Web, which was held in February 2023. This paper seeks to identify research challenges relating to governance and web architecture.
Published: 2023

13. Unbiased Supervised Contrastive Learning

Author: Barbano, Carlo Alberto, Dufumier, Benoit, Tartaglione, Enzo, Grangetto, Marco, Gori, Pietro, Università degli studi di Torino = University of Turin (UNITO), Laboratoire Traitement et Communication de l'Information (LTCI), Institut Mines-Télécom [Paris] (IMT)-Télécom Paris, Image, Modélisation, Analyse, GEométrie, Synthèse (IMAGES), Institut Mines-Télécom [Paris] (IMT)-Télécom Paris-Institut Mines-Télécom [Paris] (IMT)-Télécom Paris, Building large instruments for neuroimaging: from population imaging to ultra-high magnetic fields (BAOBAB), Service NEUROSPIN (NEUROSPIN), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), Département d'Informatique [Université de Turin], and Université de Turin
Subjects: FOS: Computer and information sciences, Computer Science - Machine Learning, Statistics - Machine Learning, Computer Vision and Pattern Recognition (cs.CV), Computer Science - Computer Vision and Pattern Recognition, Machine Learning (stat.ML), Machine Learning (cs.LG), [INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI]
Abstract: Many datasets are biased, namely they contain easy-to-learn features that are highly correlated with the target class only in the dataset but not in the true underlying distribution of the data. For this reason, learning unbiased models from biased data has become a very relevant research topic in the last years. In this work, we tackle the problem of learning representations that are robust to biases. We first present a margin-based theoretical framework that allows us to clarify why recent contrastive losses (InfoNCE, SupCon, etc.) can fail when dealing with biased data. Based on that, we derive a novel formulation of the supervised contrastive loss (epsilon-SupInfoNCE), providing more accurate control of the minimal distance between positive and negative samples. Furthermore, thanks to our theoretical framework, we also propose FairKL, a new debiasing regularization loss, that works well even with extremely biased data. We validate the proposed losses on standard vision datasets including CIFAR10, CIFAR100, and ImageNet, and we assess the debiasing capability of FairKL with epsilon-SupInfoNCE, reaching state-of-the-art performance on a number of biased datasets, including real instances of biases in the wild., Accepted at ICLR 2023 (v3); Fix typo in Eq.19 (v4)
Published: 2023

14. Linking seed size and number to trait syndromes in trees

Author: Michal Bogdziewicz, Marie‐Claire Aravena Acuña, Robert Andrus, Davide Ascoli, Yves Bergeron, Daniel Brveiller, Thomas Boivin, Raul Bonal, Thomas Caignard, Maxime Cailleret, Rafael Calama, Sergio Donoso Calderon, J. Julio Camarero, Chia‐Hao Chang‐Yang, Jerome Chave, Francesco Chianucci, Natalie L. Cleavitt, Benoit Courbaud, Andrea Cutini, Thomas Curt, Adrian J. Das, Hendrik Davi, Nicolas Delpierre, Sylvain Delzon, Michael Dietze, Laurent Dormont, William Farfan‐Rios, Catherine A. Gehring, Gregory S. Gilbert, Georg Gratzer, Cathryn H. Greenberg, Arthur Guignabert, Qinfeng Guo, Andrew Hacket‐Pain, Arndt Hampe, Qingmin Han, Kazuhiko Hoshizaki, Ines Ibanez, Jill F. Johnstone, Valentin Journé, Thomas Kitzberger, Johannes M. H. Knops, Georges Kunstler, Richard Kobe, Jonathan G. A. Lageard, Jalene M. LaMontagne, Mateusz Ledwon, Theodor Leininger, Jean‐Marc Limousin, James A. Lutz, Diana Macias, Anders Marell, Eliot J. B. McIntire, Emily Moran, Renzo Motta, Jonathan A. Myers, Thomas A. Nagel, Shoji Naoe, Mahoko Noguchi, Michio Oguro, Hiroko Kurokawa, Jean‐Marc Ourcival, Robert Parmenter, Ignacio M. Perez‐Ramos, Lukasz Piechnik, Tomasz Podgórski, John Poulsen, Tong Qiu, Miranda D. Redmond, Chantal D. Reid, Kyle C. Rodman, Pavel Šamonil, Jan Holik, C. Lane Scher, Harald Schmidt Van Marle, Barbara Seget, Mitsue Shibata, Shubhi Sharma, Miles Silman, Michael A. Steele, Jacob N. Straub, I‐Fang Sun, Samantha Sutton, Jennifer J. Swenson, Peter A. Thomas, Maria Uriarte, Giorgio Vacchiano, Thomas T. Veblen, Boyd Wright, S. Joseph Wright, Thomas G. Whitham, Kai Zhu, Jess K. Zimmerman, Magdalna Zywiec, James S. Clark, National Science Foundation (US), Belmont Forum, NASA Astrobiology Institute (US), Gordon and Betty Moore Foundation, National Science Centre (Poland), Polish National Agency for Academic Exchange, US Forest Service, Narodowe Centrum Nauki (Poland), Bogdziewicz, Michal, Aravena, Marie-Claire, Andrus, Robert, Ascoli, Davide, Bergeron, Yves, Bonal, Raul, Caignard, Thomas, Calama, Rafael, Calderon, Sergio Donoso, Camarero, J Julio, Chang-Yang, Chia-Hao, Cleavitt, Natalie L, Courbaud, Benoit, Curt, Thomas, Davi, Hendrik, Delpierre, Nicolas, Delzon, Sylvain, Dietze, Michael, Dormont, Laurent, Farfan-Rios, William, Gehring, Catherine, Gilbert, Gregory S., Gratzer, Georg, Greenberg, Cathryn H., Guignabert, Arthur, Guo,Qinfeng, Hacket-Pain, Andrew, Hampe, Arndt, Han, Qingmin, Hoshizaki, Kazuhiko, Ibáñez, Inés, Johnstone, Jill F., Journé, Valentin, Kitzberger, Thomas, Knops, Johannes M. H., Kunstler, Georges, Kobe, Richard K., Lageard, Jonathan G. A., LaMontagne, Jalene M., Ledwon, Mateusz, Leininger, Theodor, Limousin, Jean-Marc, Lutz, James A., Moran, Emily, Motta, Renzo, Myers, Jonathan A., Nagel, Thomas A., Shoji, N., Michio Oguro, Mahoko Noguchi, Ourcival, Jean-Marc, Parmenter, Robert, Perez-Ramos, Ignacio M., Piechnik, Lukasz, Poulsen, John, Qiu, Tong, Redmond, Miranda D., Reid, Chantal D., Rodman, Kyle C., Scher, C. Lane, Seget, Barbara, Silman, Miles, Sun, I-Fang, Sutton, Samantha, Swenson, Jennifer J., Thomas, Peter A., Uriarte, Maria, Vacchiano, Giorgio, Veblen, Thomas T., Wright, Boyd, Wright, S. Joseph, Zhu, Kai, Zimmerman, Jess K., Zywiec, Magdalena, Laboratoire des EcoSystèmes et des Sociétés en Montagne (UR LESSEM), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centro Austral de Investigaciones Científicas [Ushuaia] (CADIC), Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] (CONICET), Ecosystèmes forestiers (UR EFNO), Università degli studi di Torino = University of Turin (UNITO), Université du Québec en Abitibi-Témiscamingue (UQAT), AgroParisTech, Ecologie des Forêts Méditerranéennes (URFM), Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] (UCM), Biodiversité, Gènes & Communautés (BioGeCo), Université de Bordeaux (UB)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Risques, Ecosystèmes, Vulnérabilité, Environnement, Résilience (RECOVER), Aix Marseille Université (AMU)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Universidad de Chili / Departamento de Ciencias de la Computation, Instituto Pirenaico de Ecologìa = Pyrenean Institute of Ecology [Zaragoza] (IPE - CSIC), National Kaohsiung Marine University [Taïwan] (NKMU), Evolution et Diversité Biologique (EDB), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Department of Computer Science [Ithaca], Cornell University [New York], Centro di Viticoltura ed Enologia [CREA], Consiglio per la Ricerca in Agricoltura e l’analisi dell’economia agraria = Council for Agricultural Research and Economics (CREA), California Sciences Institute, Ecologie Systématique et Evolution (ESE), Université Paris-Sud - Paris 11 (UP11)-AgroParisTech-Centre National de la Recherche Scientifique (CNRS), Boston University [Boston] (BU), Centre d’Ecologie Fonctionnelle et Evolutive (CEFE), Université Paul-Valéry - Montpellier 3 (UPVM)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Montpellier, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Université de Montpellier (UM), Saint Louis University (SLU), Northern Arizona University [Flagstaff], University of California (UC), Universität für Bodenkultur Wien = University of Natural Resources and Life [Vienne, Autriche] (BOKU), USDA Agricultural Research Service [Maricopa, AZ] (USDA), United States Department of Agriculture (USDA), Interactions Sol Plante Atmosphère (UMR ISPA), Ecole Nationale Supérieure des Sciences Agronomiques de Bordeaux-Aquitaine (Bordeaux Sciences Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University of Liverpool, Forestry and Forest Products Research Institute (FFPRI), Akita University, University of Michigan [Dearborn], University of Michigan System, Nicholas School of the Environment, Duke University [Durham], Alabama Space Grant ConsortiumAIST16-0052AIST18-0063Belmont Forum1854976Polish National Agency for Academic Exchange (NAWA)PPN/BEK/2020/1/00009/U/00001National Science Centre, Poland2019/35/D/NZ8/00050National Science Foundation (NSF)DEB- 1754443, and ANR-18-MPGA-0004,FORBIC,Prévision du changement de la biodiversité(2018)
Subjects: Global and Planetary Change, Ecology, [SDV]Life Sciences [q-bio], fecundity, functional traits, leaf economics, life history strategies, size syndrome, tree recruitment, Life history strategie, Settore AGR/05 - Assestamento Forestale e Selvicoltura, Tree recruitmen, [SDE]Environmental Sciences, fecundity functional traits leaf economics life history strategies size syndrome, Ecology, Evolution, Behavior and Systematics
Abstract: 12 páginas.- 4 figuras.- referencias.- Additional supporting information can be found online in the Supporting Information section at the end of this article.- Full Access in https://onlinelibrary.wiley.com/doi/full/10.1111/geb.13652, Aim Our understanding of the mechanisms that maintain forest diversity under changing climate can benefit from knowledge about traits that are closely linked to fitness. We tested whether the link between traits and seed number and seed size is consistent with two hypotheses, termed the leaf economics spectrum and the plant size syndrome, or whether reproduction represents an independent dimension related to a seed size–seed number trade-off. Location Most of the data come from Europe, North and Central America and East Asia. A minority of the data come from South America, Africa and Australia. Time period 1960–2022. Major taxa studied Trees. Methods We gathered 12 million observations of the number of seeds produced in 784 tree species. We estimated the number of seeds produced by individual trees and scaled it up to the species level. Next, we used principal components analysis and generalized joint attribute modelling (GJAM) to map seed number and size on the tree traits spectrum. Results Incorporating seed size and number into trait analysis while controlling for environment and phylogeny with GJAM exposes relationships in trees that might otherwise remain hidden. Production of the large total biomass of seeds [product of seed number and seed size; hereafter, species seed productivity (SSP)] is associated with high leaf area, low foliar nitrogen, low specific leaf area (SLA) and dense wood. Production of high seed numbers is associated with small seeds produced by nutrient-demanding species with softwood, small leaves and high SLA. Trait covariation is consistent with opposing strategies: one fast-growing, early successional, with high dispersal, and the other slow-growing, stress-tolerant, that recruit in shaded conditions. Main conclusions Earth system models currently assume that reproductive allocation is indifferent among plant functional types. Easily measurable seed size is a strong predictor of the seed number and species seed productivity. The connection of SSP with the functional traits can form the first basis of improved fecundity prediction across global forests., The project has been funded by grants to J.S.C. from the National Science Foundation, most re-cently DEB-1754443, and by the Belmont Forum (1854976), NASA (AIST16-0052 and AIST18-0063) and the Programme d'Investissement d'Avenir under project FORBIC (18-MPGA-0004; Make Our Planet Great Again). Jerry Franklin's data remain acces-sible through NSF LTER DEB-1440409. Data from Hubbard Brook (New Hampshire) were funded through NSF-LTER. Puerto Rico data were funded by NSF grants, most recently DEB 0963447 and LTREB 11222325. Data from the Andes Biodiversity and Ecosystem Research Group were funded by the Gordon and Betty Moore Foundation and NSF 727 LTREB 1754647. M.B. was supported by grant no. 2019/35/D/NZ8/00050 from the (Polish) National Science Centre and by Polish National Agency for Academic Exchange Bekker programme PPN/BEK/2020/1/00009/U/00001. Research by the USDA Forest Service and the USGS was funded by these agencies. Any use of trade, firm or product names does not imply endorsement by the US Government. Any use of trade, firm, or product names is for descriptive purposes only and does not imply en -dorsement by the U.S. Government
Published: 2023

15. Evaluating the Effectiveness of Public Procurement Performance Management Systems in Local Governments

Author: Stefano Ronchi, Andrea Stefano Patrucco, Davide Luzzini, Université de Turin, Department of Economics, University of Turin, Università degli studi di Torino (UNITO)-Università degli studi di Torino (UNITO), Audencia Business School, Politecnico di Milano [Milan] (POLIMI), and Università degli studi di Torino = University of Turin (UNITO)-Università degli studi di Torino = University of Turin (UNITO)
Subjects: Finance, Sociology and Political Science, Performance management, Public economics, business.industry, Performance, 05 social sciences, Public sector, Public institution, Context (language use), Development, 0506 political science, Procurement, Local government, 0502 economics and business, 050602 political science & public administration, Economics, Public procurement, [SHS.GESTION]Humanities and Social Sciences/Business administration, Performance measurement, Performance indicator, business, 050203 business & management, Regulation
Abstract: International audience; Increasing the effectiveness, efficiency, and compliance of public procurement (PP) has become an ongoing concern for governments. Public administrations at different levels are realising that – in order for PP to fulfil its mission – appropriate control and diagnostic systems must be put in place. This study aims to investigate the architecture of PP performance measurement systems (PP-PMSs) in local governments, drawing on four case studies from Italy and four from Wales. The theoretical background is provided by the emerging literature on procurement PMSs in the private context as well as the specific literature on the public sector. PP-PMSs are specifically analysed with respect to performance areas covered (i.e., cost, quality, time, compliance, innovation, sustainability). Results show that performance dimensions should be extended beyond traditional cost measures, with KPIs not limited to those imposed by national/regional regulation. Furthermore, we show that this is likely to happen where the procurement function is recognised as strategic in the public institution.
Published: 2016

16. Impact of Left Ventricular Ejection Fraction on Procedural and Long-Term Outcomes of Bifurcation Percutaneous Coronary Intervention

Author: Guglielmo Gallone, Jeehoon Kang, Francesco Bruno, Jung-Kyu Han, Ovidio De Filippo, Han-Mo Yang, Mattia Doronzo, Kyung-Woo Park, Gianluca Mittone, Hyun-Jae Kang, Radoslaw Parma, Hyeon-Cheol Gwon, Enrico Cerrato, Woo Jung Chun, Grzegorz Smolka, Seung-Ho Hur, Gerard Helft, Seung Hwan Han, Saverio Muscoli, Young Bin Song, Filippo Figini, Ki Hong Choi, Giacomo Boccuzzi, Soon-Jun Hong, Daniela Trabattoni, Chang-Wook Nam, Massimo Giammaria, Hyo-Soo Kim, Federico Conrotto, Javier Escaned, Carlo Di Mario, Fabrizio D'Ascenzo, Bon-Kwon Koo, Gaetano Maria de Ferrari, Università degli studi di Torino = University of Turin (UNITO), Seoul National University Hospital, Medical University of Silesia (SUM), Samsung Medical Center Sungkyunkwan University School of Medicine, Institute Division of Hematology/Oncology, Ospedale di Rivoli [Rivoli, Italy] (OR), Keimyung University, Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] (IHU ICAN), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Gachon University Gil Medical Center [Incheon, Republic of Korea], University of Rome 'Tor Vergeta', Università degli Studi di Roma Tor Vergata [Roma], Clinica Pederzoli [Peschiera del Garda, Italy] (CP), Ospedale S.Giovanni Bosco, Korea University [Seoul], Monzino Cardiology Center [Milan, Italy] (M2C), Maria Vittoria Hospital [Turin], Centro Cardiologico Monzino [Milano], Dpt di Scienze Cliniche e di Comunità [Milano] (DISCCO), Università degli Studi di Milano = University of Milan (UNIMI)-Università degli Studi di Milano = University of Milan (UNIMI)-Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS), Instituto de Investigación Sanitaria del Hospital Clínico San Carlos [Madrid, Spain] (IdISSC), Careggi University Hospital [Florence, Italie], and Lesnik, Philippe
Subjects: [SDV] Life Sciences [q-bio], Ventricular Dysfunction, Left, Percutaneous Coronary Intervention, Treatment Outcome, [SDV]Life Sciences [q-bio], Humans, Drug-Eluting Stents, Stroke Volume, Coronary Artery Disease, Registries, Cardiology and Cardiovascular Medicine, Ventricular Function, Left, Retrospective Studies
Abstract: International audience; The association of left ventricular ejection fraction (LVEF) with procedural and long-term outcomes after state-of-the-art percutaneous coronary intervention (PCI) of bifurcation lesions remains unsettled. A total of 5,333 patients who underwent contemporary coronary bifurcation PCI were included in the intercontinental retrospective combined insights from the unified RAIN (veRy thin stents for patients with left mAIn or bifurcatioN in real life) and COBIS (COronary BIfurcation Stenting) III bifurcation registries. Of 5,003 patients (93.8%) with known baseline LVEF, 244 (4.9%) had LVEF
Published: 2022

17. PECATI: A Multicentric, Open-Label, Single-Arm Phase II Study to Evaluate the Efficacy and Safety of Pembrolizumab and Lenvatinib in Pretreated B3-Thymoma and Thymic Carcinoma Patients

Author: Laurence Bigay-Game, Miguel Sampayo, Nicolas Girard, Laurent Greillier, Benjamin Besse, Javier de Castro, Jordi Remon, Sophie Cousin, R. Bernabé, Oscar Juan, Joaquin Mosquera, Silvia Novello, Centro Integral Oncologico Clara Campal, Unité de recherche de l'institut du thorax (ITX-lab), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Institut Curie [Paris], Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil (UVSQ Santé), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Università degli studi di Torino = University of Turin (UNITO), Hospital Universitario La Paz, Service de pneumologie [Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Hospital Universitario Virgen del Rocío [Sevilla], Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hôpital Nord [CHU - APHM], Institut Bergonié [Bordeaux], UNICANCER, Hospital Universitari i Politècnic La Fe = University and Polytechnic Hospital La Fe, Institut Gustave Roussy (IGR), and Université Paris-Saclay
Subjects: Pulmonary and Respiratory Medicine, Oncology, Cancer Research, medicine.medical_specialty, Lung Neoplasms, Thymoma, [SDV.CAN]Life Sciences [q-bio]/Cancer, Second-line, Pembrolizumab, Antibodies, Monoclonal, Humanized, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, Immunotherapy, Lenvatinib, Pembrolizumab, Second-line, Thymic epithelial tumors, chemistry.chemical_compound, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, Lenvatinib, Humans, Medicine, Thymic epithelial tumors, Lung cancer, Survival rate, Thymic carcinoma, business.industry, Phenylurea Compounds, Standard treatment, Cancer, Thymus Neoplasms, medicine.disease, chemistry, Quinolines, [SDV.IMM]Life Sciences [q-bio]/Immunology, Immunotherapy, business
Abstract: International audience; Thymic epithelial tumors are rare neoplastic proliferations of thymic epithelial cells. The aggressiveness of these malignancies increases as higher is the histologic subtype, being thymic carcinoma the most aggressive subtype, with a greater tendency to metastatic spread. In metastatic setting, there is no standard treatment after progression on platinum-based chemotherapy. In this scenario, monotherapy treatment either with lenvatinib, a multi-tyrosine kinase inhibitor with antiangiogenic properties, or pembrolizumab, an immune-checkpoint inhibitor, has reported clinical activity. Potential combination of both agents may have synergistic activity as reported in other cancer types. PECATI trial is a single-arm, investigator-initiated phase II study aiming to assess the activity and safety of the combination of lenvatinib and pembrolizumab in 43 patients with advanced B3-thymoma or thymic carcinoma who progressed on or after at least one previous line of platinum-based chemotherapy. The primary endpoint of the trial is 5-month progression-free survival rate and the secondary endpoints include overall response rate, duration of response, and overall survival.
Published: 2022

18. International Association for the Study of Lung Cancer Study of the Impact of Coronavirus Disease 2019 on International Lung Cancer Clinical Trials

Author: Smeltzer, Matthew P., Scagliotti V, Giorgio, Wakelee, Heather A., Mitsudomi, Tetsuya, Roy, Upal Basu, Clark, Russell C., Arndt, Renee, Pruett, Clayton D., Kelly, Karen L., Ujhazy, Peter, Johnson, Melissa L., Eralp, Yesim, Barrios, Carlos H., Barlesi, Fabrice, Hirsch, Fred R., Bunn, Paul A., Coronavi, Int Assoc Study Lung Canc, Comm, Clinical Trials Steering, Acibadem University Dspace, Department of Thoracic Oncology, Università degli studi di Torino = University of Turin (UNITO)-San Luigi Hospital, Aichi Cancer Center Hospital, Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Institut Gustave Roussy (IGR)
Subjects: Pulmonary and Respiratory Medicine, Clinical trials, Telehealth, Lung Neoplasms, Oncology, [SDV]Life Sciences [q-bio], COVID-19, Humans, Lung cancer, Pandemics
Abstract: Introduction: To evaluate the effects of the global coronavirus disease 2019 (COVID-19) pandemic on lung cancer trials, we surveyed investigators and collected aggregate enrollment data for lung cancer trials across the world before and during the pandemic. Methods: A Data Collection Survey collected aggregate monthly enrollment numbers from 294 global lung cancer trials for 2019 to 2020. A 64-question Action Survey evaluated the impact of COVID-19 on clinical trials and identified mitigation strategies implemented. Results: Clinical trial enrollment declined from 2019 to 2020 by 14\% globally. Most reductions in enrollment occurred in April to June where we found significant decreases in individual site enrollment (p = 0.0309). Enrollment was not significantly different in October 2019 to December of 2019 versus 2020 (p = 0.25). The most frequent challenges identified by the Action Survey (N = 172) were fewer eligible patients (63\%), decrease in protocol compliance (56\%), and suspension of trials (54\%). Patient-specific challenges included access to trial site (49\%), ability to travel (54\%), and willingness to visit the site (59\%). The most frequent mitigation strategies included modified monitoring requirements (47\%), telehealth visits (45\%), modified required visits (25\%), mailorder medications (25\%), and laboratory (27\%) and radiology (21\%) tests at nonstudy facilities. Sites that felt the most effective mitigation strategies were telehealth visits (85\%), remote patient-reported symptom collection (85\%), off-site procedures (85\%), and remote consenting (89\%).Conclusions: The COVID-19 pandemic created many challenges for lung cancer clinical trials conduct and enrollment. Mitigation strategies were used and, although the pandemic worsened, trial enrollment improved. A more flexible approach may improve enrollment and access to clinical trials, even beyond the pandemic.(c) 2022 Published by Elsevier Inc. on behalf of International Association for the Study of Lung Cancer.
Published: 2022

19. Simplicially driven simple contagion

Author: Maxime Lucas, Iacopo Iacopini, Thomas Robiglio, Alain Barrat, Giovanni Petri, ISI Foundation Institute for Scientific Interchange, Central European University Vienna, Dipartimento di Fisica [Torino], Università degli studi di Torino = University of Turin (UNITO), CPT - E5 Physique statistique et systèmes complexes, Centre de Physique Théorique - UMR 7332 (CPT), Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), and ANR-19-CE46-0008,DataRedux,Réduction de données massives pour la simulation numérique prédictive(2019)
Subjects: Social and Information Networks (cs.SI), FOS: Computer and information sciences, Physics - Physics and Society, [PHYS.PHYS.PHYS-SOC-PH]Physics [physics]/Physics [physics]/Physics and Society [physics.soc-ph], FOS: Physical sciences, General Physics and Astronomy, Computer Science - Social and Information Networks, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Physics and Society (physics.soc-ph), [PHYS.PHYS.PHYS-DATA-AN]Physics [physics]/Physics [physics]/Data Analysis, Statistics and Probability [physics.data-an]
Abstract: Single contagion processes are known to display a continuous transition from an epidemic-free phase at low contagion rates to the epidemic state for rates above a critical threshold. This transition can become discontinuous when two simple contagion processes are coupled in a bi-directional symmetric way. However, in many cases, the coupling is not symmetric and the processes can be of a different nature. For example, risky social behaviors -- such as not wearing masks or engaging in large gatherings -- can affect the spread of a disease, and their adoption dynamics via social reinforcement mechanisms are better described by complex contagion models, rather than by the simple contagion paradigm, which is more appropriate for disease spreading phenomena. Motivated by this example, we consider a simplicial contagion (describing the adoption of a behavior) that uni-directionally drives a simple contagion (describing a disease propagation). We show that, above a critical driving strength, such driven simple contagion can exhibit both discontinuous transitions and bi-stability, which are instead absent in standard simple contagions. We provide a mean-field analytical description of the phase diagram of the system, and complement the results with Markov-chain simulations. Our results provide a novel route for a simple contagion process to display the phenomenology of a higher-order contagion, through a driving mechanism that may be hidden or unobservable in many practical instances., Comment: 10 pages, 7 figures. I.I. and M.L. contributed equally to this work. A.B and G.P. jointly supervised this work
Published: 2023

20. Measuring the Performance of iCloud Private Relay

Author: Martino, Trevisan, Drago, Idilio, Schmitt, Paul, Bronzino, Francesco, University of Trieste, Italy, Dipartimento di Informatica [Torino], Università degli studi di Torino = University of Turin (UNITO), University of Hawaii, Holistic Wireless Networks (hownet), Laboratoire de l'Informatique du Parallélisme (LIP), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS), and École normale supérieure de Lyon (ENS de Lyon)
Subjects: [INFO.INFO-NI]Computer Science [cs]/Networking and Internet Architecture [cs.NI]
Abstract: International audience; Recent developments in Internet protocols and services aim to provide enhanced security and privacy for users' traffic. Apple's iCloud Private Relay is a premier example of this trend, introducing a wellprovisioned, multi-hop architecture to protect the privacy of users' traffic while minimizing the traditional drawbacks of additional network hops (e.g., latency). Announced in 2021, the service is currently in the beta stage, offering an easy and cheap privacy-enhancing alternative directly integrated into Apple's operating systems. This seamless integration makes a future massive adoption of the technology very likely, calling for studies on its impact on the Internet. Indeed, the iCloud Private Relay architecture inherently introduces computational and routing overheads, possibly hampering performance. In this work, we study the service from a performance perspective, across a variety of scenarios and locations. We show that iCloud Private Relay not only reduces speed test performance (up to 10x decrease) but also negatively affects page load time and download/upload throughput in different scenarios. Interestingly, we find that the overlay routing introduced by the service may increase performance in some cases. Our results call for further investigations into the effects of a large-scale deployment of similar multi-hop privacy-enhancing architectures. For increasing the impact of our work we contribute our software and measurements to the community.
Published: 2023

21. Pour une socio-histoire localisée des transitions énergétiques

Author: Bini, Elisabetta, Curli, Barbara, Fournier, Pierre, Mattina, Cesare, Université de Naples - Frederico II, Université de Turin, Università degli studi di Torino = University of Turin (UNITO), Centre méditerranéen de sociologie, de science politique et d’histoire (Mesopolhis), and Sciences Po Aix - Institut d'études politiques d'Aix-en-Provence (IEP Aix-en-Provence)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)
Subjects: territoire, [SHS.SOCIO]Humanities and Social Sciences/Sociology, [SHS.HIST]Humanities and Social Sciences/History, [SHS.SCIPO]Humanities and Social Sciences/Political science, énergie, [SHS]Humanities and Social Sciences
Abstract: Introduction à l'ouvrage Les territoires des transitions énergétiques (Karthala, MMSH, 2023), précisant l'interrogation sur la part des dynamiques locales dans les orientations énergétiques, le périmètre d'étude (nucléaire et énergies renouvelables), l'échelle de temps (depuis la 2e guerre mondiale), la démarche comparative entre Italie et France (aux trajectoires contrastées), la complémentarité des regards historiens et sociologiques
Published: 2023

22. Les Territoires des transitions énergétiques. Nucléaire et énergies renouvelables en Italie et en France

Author: Mattina, Cesare, Bini, Elisabetta, Curli, Barbara, Fournier, Pierre, Centre méditerranéen de sociologie, de science politique et d’histoire (Mesopolhis), Sciences Po Aix - Institut d'études politiques d'Aix-en-Provence (IEP Aix-en-Provence)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Université de Naples - Frederico II, Università degli studi di Torino = University of Turin (UNITO), Ce travail a été réalisé dans le cadre du laboratoire d’excellence LabexMed – Les sciences humaines et sociales au coeur de l’interdisciplinarité pour la Méditerranée portant la référence10–LABX–0090., Ce travail a bénéficié d’une aide du gouvernement français au titre du Programme Investissements d’Avenir, Initiative d’Excellence d’Aix-Marseille Université – A*MIDEX., Cet ouvrage a bénéficié du soutien financier du Centre méditerranéen de sociologie, de science politique et d’histoire (Mesopolhis, CNRS-Aix-Marseille Université-Sciences Po Aix)., and Emmanuelle Chapron Le Bianic
Subjects: territoire, nucléaire, [SHS.SOCIO]Humanities and Social Sciences/Sociology, photovoltaïque, mobilisation, industrie, éolien, [SHS.HIST]Humanities and Social Sciences/History, [SHS.SCIPO]Humanities and Social Sciences/Political science, énergie, [SHS]Humanities and Social Sciences
Abstract: International audience; La « transition énergétique » est aujourd'hui présentée dans le débat public sur le mode de l'évidence, comme si nos sociétés allaient connaître un même mouvement pour passer des mauvaises énergies fossiles aux bonnes énergies renouvelables. L'analyse sous le seul angle des politiques internationales ne suffit cependant pas à en saisir les conditions. Dans cet ouvrage, les auteurs proposent d'observer les réorientations énergétiques au présent comme au passé, « par le haut » comme « par le bas », telles qu'elles se négocient localement dans les territoires d'installation du nucléaire et des énergies renouvelables photovoltaïques et éoliennes.Les enquêtes socio-historiques menées dans différents contextes locaux en Italie et en France motivent la comparaison entre ces deux pays de la Méditerranée, contrastés en termes de mix énergétique et de dynamiques de choix : avec un nucléaire en déconstruction en Italie et toujours dominant dans la production électrique française ; avec des développements d'énergies renouvelables plus avancés en Italie qu'en France ; et avec des difficultés semblables pour se défaire du pétrole et du gaz. Dans les deux cas, les processus territoriaux de transition énergétique interrogent les choix des politiques publiques oscillant entre la décentralisation régionale et la tentation constante de recentralisation étatique.
Published: 2023

23. Consensus Statement on the definition and classification of metabolic hyperferritinaemia

Author: Luca Valenti, Elena Corradini, Leon A. Adams, Elmar Aigner, Saleh Alqahtani, Marco Arrese, Edouard Bardou-Jacquet, Elisabetta Bugianesi, Jose-Manuel Fernandez-Real, Domenico Girelli, Hannes Hagström, Benjamin Henninger, Kris Kowdley, Guido Ligabue, Donald McClain, Fabrice Lainé, Koji Miyanishi, Martina U. Muckenthaler, Alessia Pagani, Patrizia Pedrotti, Antonello Pietrangelo, Daniele Prati, John D. Ryan, Laura Silvestri, C. Wendy Spearman, Per Stål, Emmanuel A. Tsochatzis, Francesca Vinchi, Ming-Hua Zheng, Heinz Zoller, Università degli Studi di Milano = University of Milan (UNIMI), Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE), The University of Western Australia (UWA), Paracelsus Medizinische Privatuniversität = Paracelsus Medical University (PMU), Johns Hopkins University (JHU), Pontificia Universidad Católica de Chile (UC), Nutrition, Métabolismes et Cancer (NuMeCan), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), CHU Pontchaillou [Rennes], Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Università degli studi di Torino = University of Turin (UNITO), Universitat de Girona [Girona], Universitat de Girona (UdG), Università degli studi di Verona = University of Verona (UNIVR), Karolinska University Hospital [Stockholm], Leopold Franzens Universität Innsbruck - University of Innsbruck, Washington State University (WSU), Wake Forest School of Medicine [Winston-Salem], Wake Forest Baptist Medical Center, Sapporo Medical University School of Medicine, Sapporo Medical University, Heidelberg University, IRCCS Ospedale San Raffaele [Milan, Italy], ASST Great Metropolitan Niguarda / ASST Grande Ospedale Metropolitano Niguarda [Milan, Italia], Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Royal College of Surgeons in Ireland (RCSI), University of Cape Town, University College of London [London] (UCL), Weill Cornell Medicine [New York], The First Affiliated Hospital of Wenzhou Medical University [Wenzhou, China], Innsbruck Medical University = Medizinische Universität Innsbruck (IMU), Ministero della Salute, Ricerca Finalizzata RF-2016-02364358, RC Rete cardiologica ‘CV PREVITAL’, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico ‘Liver BIBLE’ (PR-0391), Innovative Medicines Initiative 2 joint undertaking of European Union’s Horizon 2020 research and innovation programme and EFPIA European Union (EU) Programme Horizon 2020 (under grant agreement No. 777377) for the project LITMUS, H2020 under grant agreement ‘101016726’, the European Union, programme ‘Photonics’ under grant agreement ‘101016726’ for L.V. Fondo Nacional de Ciencia y Tecnología de Chile (FONDECYT #1191145 to M.A.) and from the Agencia Nacional de Investigación y Desarrollo, ANID through ANID ACE 210009 grant for M.A. NIH (P30DK124723), and Veterans Administration (2I01 BX001140) for D.M. SFB1036, SFB1118 and DFG (FerrOs — FOR5146, SPP2306) as well as Marsilius Kolleg for M.U.M. National Natural Science Foundation of China (82070588), High Level Creative Talents from Department of Public Health in Zhejiang Province (S2032102600032) for M.-H.Z. Swedish Cancer Society (170690) and Stockholm County Council (K2017-4579) for P.S., Jonchère, Laurent, Weill Cornell Medicine [Cornell University], and Cornell University [New York]
Subjects: [SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, iron, Endocrinology, iron, hyperferritinemia, metabolic syndrome, Endocrinology, Diabetes and Metabolism, hyperferritinemia, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, metabolic syndrome
Abstract: International audience; Hyperferritinaemia is a common laboratory finding that is often associated with metabolic dysfunction and fatty liver. Metabolic hyperferritinaemia reflects alterations in iron metabolism that facilitate iron accumulation in the body and is associated with an increased risk of cardiometabolic and liver diseases. Genetic variants that modulate iron homeostasis and tissue levels of iron are the main determinants of serum levels of ferritin in individuals with metabolic dysfunction, raising the hypothesis that iron accumulation might be implicated in the pathogenesis of insulin resistance and the related organ damage. However, validated criteria for the non-invasive diagnosis of metabolic hyperferritinaemia and the staging of iron overload are still lacking, and there is no clear evidence of a benefit for iron depletion therapy. Here, we provide an overview of the literature on the relationship between hyperferritinaemia and iron accumulation in individuals with metabolic dysfunction, and on the associated clinical outcomes. We propose an updated definition and a provisional staging system for metabolic hyperferritinaemia, which has been agreed on by a multidisciplinary global panel of expert researchers. The goal is to foster studies into the epidemiology, genetics, pathophysiology, clinical relevance and treatment of metabolic hyperferritinaemia, for which we provide suggestions on the main unmet needs, optimal design and clinically relevant outcomes.
Published: 2023

24. Occupational Exposure to Polycyclic Aromatic Hydrocarbons and Lung Cancer Risk: Results from a Pooled Analysis of Case–Control Studies (SYNERGY)

Author: Olsson, Ann, Guha, Neela, Bouaoun, Liacine, Kromhout, Hans, Peters, Susan, Siemiatycki, Jack, Ho, Vikki, Gustavsson, Per, Boffetta, Paolo, Vermeulen, Roel, Behrens, Thomas, Bruning, Thomas, Kendzia, Benjamin, Guénel, Pascal, Luce, Danièle, Karrasch, Stefan, Wichmann, Heinz-Erich, Consonni, Dario, Landi, Maria Teresa, Caporaso, Neil E, Merletti, Franco, Mirabelli, Dario, Richiardi, Lorenzo, Jöckel, Karl-Heinz, Ahrens, Wolfgang, Pohlabeln, Hermann, Tardon, Adonina, Zaridze, David, Field, John K, Lissowska, Jolanta, Świątkowska, Beata, McLaughlin, John R, Demers, Paul A, Bencko, Vladimir, Foretova, Lenka, Janout, Vladimir, Pandics, Tamas, Fabianova, Eleonora, Mates, Dana, Forastiere, Francesco, Bueno-de-Mesquita, Bas, Schüz, Joachim, Straif, Kurt, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Centre International de Recherche contre le Cancer - International Agency for Research on Cancer (CIRC - IARC), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Utrecht University [Utrecht], Université de Montréal (UdeM), Karolinska Institutet [Stockholm], University of Bologna/Università di Bologna, Stony Brook University [SUNY] (SBU), State University of New York (SUNY), Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), École des Hautes Études en Santé Publique [EHESP] (EHESP), Ludwig Maximilian University [Munich] (LMU), Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, National Cancer Institute [Bethesda] (NCI-NIH), National Institutes of Health [Bethesda] (NIH), Department of Medical Sciences [Turin, Italy] (DMS), Università degli studi di Torino = University of Turin (UNITO), Universitätsklinikum Essen [Universität Duisburg-Essen] (Uniklinik Essen), Universität Bremen, Leibniz Institute for Prevention Research and Epidemiology - BIPS, Leibniz Association, University of Oviedo, N.N. Blokhin National Medical Research Center of Oncology, University of Liverpool, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology (MCMCC), Nofer Institute of Occupational Medicine (NIOM), University of Toronto, Occupational Cancer Research Centre, First Faculty of Medicine, Charles University [Prague] (CU), Masaryk Memorial Cancer Institute (MMCI), Faculty of Health Sciences [UEF, Kuopio, Finland], University of Eastern Finland, National Public Health Center, National Institute of Public Health [Romania] (INSP), Azienda Sanitaria Locale [ROMA] (ASL), National Institute for Public Health and the Environment [Bilthoven] (RIVM), Instituto de Salud Global - Institute For Global Health [Barcelona] (ISGlobal), Boston College (BC), and Chard-Hutchinson, Xavier
Subjects: Male, Lung Neoplasms, Epidemiology, Medizin, [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, [SDV.CAN] Life Sciences [q-bio]/Cancer, Oncology, polycyclic aromatic hydrocarbons, benzo[a]pyrene, lung cancer, occupational exposures, case-control study, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Case-Control Studies, Occupational Exposure, Carcinogens, Humans, [SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Polycyclic Aromatic Hydrocarbons, Lung
Abstract: German Social Accident Insurance (DGUV) between 2007 and 2011, Olsson A, Guha N, Bouaoun L, Kromhout H, Peters S, Siemiatycki J, Ho V, Gustavsson P, Boffetta P, Vermeulen R, Behrens T, Brüning T, Kendzia B, Guénel P, Luce D, Karrasch S, Wichmann HE, Consonni D, Landi MT, Caporaso NE, Merletti F, Mirabelli D, Richiardi L, Jöckel KH, Ahrens W, Pohlabeln H, Tardón A, Zaridze D, Field JK, Lissowska J, Świątkowska B, McLaughlin JR, Demers PA, Bencko V, Foretova L, Janout V, Pándics T, Fabianova E, Mates D, Forastiere F, Bueno-de-Mesquita B, Schüz J, Straif K
Published: 2022

25. A structural homologue of the plant receptor D14 mediates responses to strigolactones in the fungal phytopathogen Cryphonectria parasitica

Author: Valentina Fiorilli, Marco Forgia, Alexandre Saint Germain, Giulia D’Arrigo, David Cornu, Philippe Le Bris, Salim Al‐Babili, Francesca Cardinale, Cristina Prandi, Francesca Spyrakis, François‐Didier Boyer, Massimo Turina, Luisa Lanfranco, Dipartimento di Scienze della Vita e Biologia dei Sistemi, Università degli studi di Torino = University of Turin (UNITO), CNR Istituto per la Protezione Sostenibile delle Piante [Torino, Italia] (IPSP), National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR), Institut Jean-Pierre Bourgin (IJPB), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), King Abdullah University of Science and Technology (KAUST), Institut de Chimie des Substances Naturelles (ICSN), Institut de Chimie du CNRS (INC)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), CRG2017/King Abdullah University of Science and TechnologyEuropean CommissionUniversità degli Studi di Torinoshort-term mobility COST fellowship (COST Action)FA 1206Infrastructures en Biologie Sante et AgronomieRegion Ile-de-FrancePlan Cancer, ANR-11-LABX-0039,CHARMMMAT,CHimie des ARchitectures MoléculairesMultifonctionnelles et des MATériaux(2011), and ANR-17-EURE-0007,SPS-GSR,Ecole Universitaire de Recherche de Sciences des Plantes de Paris-Saclay(2017)
Subjects: integumentary system, Physiology, fungi, fungus, strigolactones, Plant Science, perception, [SDV.BV.PEP]Life Sciences [q-bio]/Vegetal Biology/Phytopathology and phytopharmacy, apocarotenoids, Lactones, Ascomycota, Plant Growth Regulators, α/β-hydrolase, apocarotenoids, Cryphonectria parasitica, D14, fungus, perception, strigolactones, D14, α/β-hydrolase, Heterocyclic Compounds, 3-Ring, Cryphonectria parasitica, [SDV.MP.MYC]Life Sciences [q-bio]/Microbiology and Parasitology/Mycology, Plant Proteins
Abstract: International audience; Strigolactones (SLs) are plant hormones and important signaling molecules required to promote the arbuscular mycorrhizal (AM) symbiosis. While in plants an α/β-hydrolase, DWARF14 (D14), was shown to act as a receptor that binds and cleaves SLs, the fungal receptor for SLs is unknown.Since AM fungi are currently not genetically tractable, in this study, we used the fungal pathogen Cryphonectria parasitica for which gene deletion protocols exist, as a model, as we have previously shown that it responds to SLs. By means of computational, biochemical and genetic analyses we identified a D14 structural homologue, CpD14.Molecular homology modelling and docking support the prediction that CpD14 interacts with and hydrolyses SLs. The recombinant CpD14 protein shows α/β hydrolytic activity in vitro against the SLs synthetic analogue GR24; its enzymatic activity requires an intact Ser/His/Asp catalytic triad. CpD14 expression in the d14-1 loss-of-function Arabidopsis thaliana line did not rescue the plant mutant phenotype. However, gene inactivation by knock-out homologous recombination reduced fungal sensitivity to SLs.These results indicate that CpD14 is involved in SLs responses in C. parasitica and strengthen the role of SLs as multifunctional molecules acting in plant microbe-interactions.
Published: 2022

26. NALCN-mediated sodium influx confers metastatic prostate cancer cell invasiveness

Author: Folcher, Antoine, Gordienko, Dmitri, Iamshanova, Oksana, Bokhobza, Alexandre, Shapovalov, George, Kannancheri-Puthooru, Dheeraj, Mariot, Pascal, Allart, Laurent, Desruelles, Emilie, Spriet, Corentin, Diez, Raquel, Oullier, Thibauld, Marionneau-Lambot, Séverine, Brisson, Lucie, Geraci, Sandra, Impheng, Hathaichanok, Lehen'Kyi, V'Yacheslav, Haustrate, Aurélien, Mihalache, Adriana, Gosset, Pierre, Chadet, Stéphanie, Retif, Stéphanie, Laube, Maryline, Sobilo, Julien, Lerondel, Stéphanie, Villari, Giulia, Serini, Guido, Pla, Alessandra Fiorio, Roger, Sébastien, Fromont-Hankard, Gaelle, Djamgoz, Mustafa, Clezardin, Philippe, Monteil, Arnaud, Prevarskaya, Natalia, Laboratoire de Physiologie Cellulaire : Canaux ioniques, inflammation et cancer - U 1003 (PHYCELL), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Site de Recherche Intégrée en Cancérologie (SIRIC-ONCOLille), Université de Lille, Sciences et Technologies-Université de Lille, Sciences Humaines et Sociales-Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] (UNICANCER/Lille), Université de Lille-UNICANCER-Université de Lille-UNICANCER-Cancéropole Nord-Ouest-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 (UGSF), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Universidad de Extremadura - University of Extremadura (UEX), Cancéropôle du Grand Ouest, Université de Nantes (UN), Nutrition, croissance et cancer (U 1069) (N2C), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Physiopathologie, diagnostic et traitements des maladies osseuses / Pathophysiology, Diagnosis & Treatments of Bone Diseases (LYOS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM), Naresuan University, Université catholique de Lille (UCL), EA4245 - Transplantation, Immunologie, Inflammation [Tours] (T2i), Université de Tours (UT), Transgenèse et archivage d'animaux modèles (TAAM), Centre National de la Recherche Scientifique (CNRS), French National Infrastructure for Mouse Phenogenomics (PHENOMIN), Centre d'Imagerie du Petit Animal (CIPA), Université d'Orléans (UO), Università degli studi di Torino = University of Turin (UNITO), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Imperial College London, Cyprus International University, Institut de Génomique Fonctionnelle (IGF), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), LabEx Ion Channels Science and Therapeutics [France], and ANR-11-LABX-0015,ICST,Canaux ioniques d'intérêt thérapeutique(2011)
Subjects: Sodium leak channel, calcium oscillations, invasion, oncochannelopathy, vesicle secretion, [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology
Abstract: International audience; There is growing evidence that ion channels are critically involved in cancer cell invasiveness and metastasis. However, the molecular mechanisms of ion signaling promoting cancer behavior are poorly understood and the complexity of the underlying remodeling during metastasis remains to be explored. Here, using a variety of in vitro and in vivo techniques, we show that metastatic prostate cancer cells acquire a specific Na+ /Ca2+ signature required for persistent invasion. We identify the Na+ leak channel, NALCN, which is overexpressed in metastatic prostate cancer, as a major initiator and regulator of Ca2+ oscillations required for invadopodia formation. Indeed, NALCN-mediated Na+ influx into cancer cells maintains intracellular Ca2+ oscillations via a specific chain of ion transport proteins including plasmalemmal and mitochondrial Na+ /Ca2+ exchangers, SERCA and store-operated channels. This signaling cascade promotes activity of the NACLN-colocalized proto-oncogene Src kinase, actin remodeling and secretion of proteolytic enzymes, thus increasing cancer cell invasive potential and metastatic lesions in vivo. Overall, our findings provide new insights into an ion signaling pathway specific for metastatic cells where NALCN acts as persistent invasion controller.
Published: 2023

27. Prosodie du corse

Author: Romano, Antonio, Boula De Mareüil, Philippe, Lai, Jean-Pierre, Laboratorio di Fonetica Sperimentale 'Arturo Genre' (LFSAG), Università degli studi di Torino (UNITO), Laboratoire d'Informatique pour la Mécanique et les Sciences de l'Ingénieur (LIMSI), Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), GIPSA-Services (GIPSA-Services), Grenoble Images Parole Signal Automatique (GIPSA-lab), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), GIPSA - SYstèmes Linguistiques, Dialectologie et Oralité (GIPSA-SYLDO), GIPSA Pôle Parole et Cognition (GIPSA-PPC), Université Grenoble Alpes (UGA)-Grenoble Images Parole Signal Automatique (GIPSA-lab), Università degli studi di Torino = University of Turin (UNITO), Traitement du Langage Parlé (TLP ), Laboratoire Interdisciplinaire des Sciences du Numérique (LISN), Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Sciences et Technologies des Langues (STL), and Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)
Subjects: ComputingMilieux_MISCELLANEOUS, [SHS]Humanities and Social Sciences
Abstract: International audience
Published: 2023

28. The role of fire disturbances, human activities and climate change for long-term forest dynamics in upper-montane forests of the central Dinaric Alps

Author: Eleonora Cagliero, Laure Paradis, Niccolò Marchi, Zsuzsa Lisztes-Szabó, Mihály Braun, Katalin Hubay, Pierre Sabatier, Milić Čurović, Velibor Spalevic, Renzo Motta, Emanuele Lingua, Walter Finsinger, Università degli Studi di Padova = University of Padua (Unipd), Institut des Sciences de l'Evolution de Montpellier (UMR ISEM), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Environnements, Dynamiques et Territoires de Montagne (EDYTEM), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), University of Montenegro (UCG), Università degli studi di Torino = University of Turin (UNITO), University of Padova, grant number DOR1957359/19, and ISEM (University of Montpellier, CNRS, IRD, EPHE)
Subjects: Archeology, Global and Planetary Change, mountain forests, Ecology, Holocene, vegetation dynamics, [SDE.MCG]Environmental Sciences/Global Changes, Paleontology, [SDE.ES]Environmental Sciences/Environmental and Society, Montenegro, fire history, vegetation-fire interactions, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, Earth-Surface Processes
Abstract: International audience; We present the first high-resolution Holocene pollen, plant-macrofossil, and charcoal records from the upper-montane zone in the central Dinaric Alps. Drawing on these new records from well-dated lacustrine sediments of Zminje Jezero (ca. 1500 m a.s.l.; Montenegro) and on independent chironomid-inferred summer temperatures, we explore long-term ecosystem responses to variations in climate, fire disturbances and land use, as well as legacy effects of past environmental changes. A mixed spruce-fir forest established in the upper-montane zone around 9500 cal BP, and Fagus sylvatica became co-dominant with the two conifers after 5000 cal BP. Prehistoric land-use pressure was overall remarkably low, but increased since 2000 cal BP and was highest after the Middle Ages. We found a significant positive relationship between biomass burning and summer temperature, indicating that fires were mostly climate driven. Picea abies was insensitive to summer temperature, biomass burning and human impact, which supports the view that spruce forests may not be significantly impacted by fire. In contrast, Abies alba and other disturbance-sensitive trees ( Tilia, Ulmus, Fraxinus excelsior-type) show significant negative responses to land-use pressure and positive responses to summer temperature. This supports the notion that these species may be well-adapted to warmer-than present summer temperatures and that their populations declined in recent millennia due to land-use activities. Conversely, F. sylvatica was sensitive to summer temperatures but was promoted by low biomass burning, indicating that its expansion in the spruce-fir dominated forest was enhanced by the onset of cooler and possibly also moister climatic conditions as well as by fire disturbances.
Published: 2023

29. In Humanized Sickle Cell Mice, Imatinib Protects Against Sickle Cell-Related Injury

Author: Enrica Federti, Alessandro Matte, Antonio Recchiuti, Francesca Garello, Alessandra Ghigo, Wassim El Nemer, Enzo Terreno, Angela Amoresano, Domenico Mattoscio, Franco Turrini, Christophe Lebouef, Anne Janin, Antonella Pantaleo, Roberta Russo, Mickael Marin, Iana Iatcencko, Veronica Riccardi, Angela Siciliano, Achille Iolascon, Carlo Brugnara, Lucia De Franceschi, Università degli studi di Verona = University of Verona (UNIVR), University G. d'Annunzio Chieti, Università degli studi 'G. d'Annunzio' Chieti-Pescara [Chieti-Pescara] (Ud'A), Università degli studi di Torino = University of Turin (UNITO), Department of Oncology [University of Turin], Anthropologie bio-culturelle, Droit, Ethique et Santé (ADES), and Aix Marseille Université (AMU)-EFS ALPES MEDITERRANEE-Centre National de la Recherche Scientifique (CNRS)
Subjects: [SDV]Life Sciences [q-bio], Hematology
Published: 2023

30. Recurrence-Free Survival in Early and Locally Advanced Large Cell Neuroendocrine Carcinoma of the Lung after Complete Tumor Resection

Author: Barbara Altieri, Anna La Salvia, Roberta Modica, Francesca Marciello, Olaf Mercier, Pier Luigi Filosso, Bertrand Richard de Latour, Dario Giuffrida, Severo Campione, Gianluca Guggino, Elie Fadel, Mauro Papotti, Annamaria Colao, Jean-Yves Scoazec, Eric Baudin, Antongiulio Faggiano, University of Würzburg = Universität Würzburg, 'Federico II' University of Naples Medical School, Hôpital Marie-Lannelongue, Università degli studi di Torino = University of Turin (UNITO), CHU Pontchaillou [Rennes], Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Università degli studi di Catania = University of Catania (Unict), Institut Gustave Roussy (IGR), Analyse moléculaire, modélisation et imagerie de la maladie cancéreuse (AMMICa), Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Médecine nucléaire, Département d'imagerie médicale [Gustave Roussy], Institut Gustave Roussy (IGR)-Institut Gustave Roussy (IGR), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), This research was funded by POR Campania FESR 2014-2020 and 'RARE.PLAT.NET' CUP B63D18000380007 (to A.C.)., Altieri, Barbara, La Salvia, Anna, Modica, Roberta, Marciello, Francesca, Mercier, Olaf, Luigi Filosso, Pier, Richard de Latour, Bertrand, Giuffrida, Dario, Campione, Severo, Guggino, Gianluca, Fadel, Elie, Papotti, Mauro, Colao, Annamaria, Scoazec, Jean-Yve, Baudin, Eric, and Faggiano, Antongiulio
Subjects: lcnec, [SDV]Life Sciences [q-bio], Medicine (miscellaneous), adjuvant therapy, age, lymph nodes, neuroendocrine tumor, prognosis, prognostic marker, pulmonary cancer, surgery, survival, lymph node, prognosi
Abstract: International audience; Background: Large Cell Neuroendocrine Carcinoma (LCNEC) is a rare subtype of lung cancer with poor clinical outcomes. Data on recurrence-free survival (RFS) in early and locally advanced pure LCNEC after complete resection (R0) are lacking. This study aims to evaluate clinical outcomes in this subgroup of patients and to identify potential prognostic markers. Methods: Retrospective multicenter study including patients with pure LCNEC stage I-III and R0 resection. Clinicopathological characteristics, RFS, and disease-specific survival (DSS) were evaluated. Univariate and multivariate analyses were performed. Results: 39 patients (M:F = 26:13), with a median age of 64 years (44–83), were included. Lobectomy (69.2%), bilobectomy (5.1%), pneumonectomy (18%), and wedge resection (7.7%) were performed mostly associated with lymphadenectomy. Adjuvant therapy included platinum-based chemotherapy and/or radiotherapy in 58.9% of cases. After a median follow-up of 44 (4–169) months, the median RFS was 39 months with 1-, 2- and 5-year RFS rates of 60.0%, 54.6%, and 44.9%, respectively. Median DSS was 72 months with a 1-, 2- and 5-year rate of 86.8, 75.9, and 57.4%, respectively. At multivariate analysis, age (cut-off 65 years old) and pN status were independent prognostic factors for both RFS (HR = 4.19, 95%CI = 1.46–12.07, p = 0.008 and HR = 13.56, 95%CI 2.45–74.89, p = 0.003, respectively) and DSS (HR = 9.30, 95%CI 2.23–38.83, p = 0.002 and HR = 11.88, 95%CI 2.28–61.84, p = 0.003, respectively). Conclusion: After R0 resection of LCNEC, half of the patients recurred mostly within the first two years of follow-up. Age and lymph node metastasis could help to stratify patients for adjuvant therapy. © 2023 by the authors.
Published: 2023

31. Le livre de Bonola sur la géométrie non euclidienne (1906). Sources et enjeux scientifique et pédagogique

Author: Tazzioli, Rossana, Giacardi, Livia, Laboratoire Paul Painlevé (LPP), Université de Lille-Centre National de la Recherche Scientifique (CNRS), and Università degli studi di Torino = University of Turin (UNITO)
Subjects: [MATH.MATH-HO]Mathematics [math]/History and Overview [math.HO], [MATH]Mathematics [math]
Abstract: International audience
Published: 2023

32. On reduction and normalization in the computational core

Author: Claudia Faggian, Giulio Guerrieri, Ugo de’ Liguoro, Riccardo Treglia, Institut de Recherche en Informatique Fondamentale (IRIF (UMR_8243)), Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire d'Informatique et Systèmes (LIS), Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Huawei Technologies Edinburgh, and Università degli studi di Torino = University of Turin (UNITO)
Subjects: FOS: Computer and information sciences, Computer Science - Logic in Computer Science, Computer Science - Programming Languages, Computational lambda-calculus, [INFO.INFO-LO]Computer Science [cs]/Logic in Computer Science [cs.LO], 68N18, Logic in Computer Science (cs.LO), Computer Science Applications, rewriting, Mathematics (miscellaneous), normalization, factorization, Computational lambda-calculus, rewriting, factorization, normalization, Programming Languages (cs.PL)
Abstract: We study the reduction in a $\lambda$ -calculus derived from Moggi’s computational one, which we call the computational core. The reduction relation consists of rules obtained by orienting three monadic laws. Such laws, in particular associativity and identity, introduce intricacies in the operational analysis. We investigate the central notions of returning a value versus having a normal form and address the question of normalizing strategies. Our analysis relies on factorization results.
Published: 2023

33. Lifestyle correlates of eight breast cancer-related metabolites: a cross-sectional study within the EPIC cohort

Author: Mathilde His, Vivian Viallon, Laure Dossus, Julie A. Schmidt, Ruth C. Travis, Marc J. Gunter, Kim Overvad, Cecilie Kyrø, Anne Tjønneland, Lucie Lécuyer, Joseph A. Rothwell, Gianluca Severi, Theron Johnson, Verena Katzke, Matthias B. Schulze, Giovanna Masala, Sabina Sieri, Salvatore Panico, Rosario Tumino, Alessandra Macciotta, Jolanda M. A. Boer, Evelyn M. Monninkhof, Karina Standahl Olsen, Therese H. Nøst, Torkjel M. Sandanger, Antonio Agudo, Maria-Jose Sánchez, Pilar Amiano, Sandra M. Colorado-Yohar, Eva Ardanaz, Linda Vidman, Anna Winkvist, Alicia K. Heath, Elisabete Weiderpass, Inge Huybrechts, Sabina Rinaldi, International Agency for Cancer Research (IACR), University of Oxford, Aarhus University [Aarhus], Danish Cancer Society Research Center [Copenhagen, Denmark] (DCSRC), University of Copenhagen = Københavns Universitet (UCPH), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Università degli Studi di Firenze = University of Florence (UniFI), Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), German Institute of Human Nutrition Potsdam-Rehbruecke [Nuthetal, Germany] (GIHNP-R), University of Potsdam = Universität Potsdam, Istituto per lo Studio, la Prevenzione e la rete Oncologica [Florence, Italy] (ISPRO), IRCCS Istituto Nazionale dei Tumori [Milano], University of Naples Federico II = Università degli studi di Napoli Federico II, Provincial Health Authority (ASP 7) [Ragusa, Italy], Università degli studi di Torino = University of Turin (UNITO), National Institute for Public Health and the Environment [Bilthoven] (RIVM), University Medical Center [Utrecht], The Arctic University of Norway [Tromsø, Norway] (UiT), Catalan Institute of Oncology [Barcelone, Espagne], L’Hospitalet de Llobregat [Barcelona, Spain], Escuela Andaluza de Salud Pública [Granada, Spain] (EASP), Universidad de Granada = University of Granada (UGR), CIBER de Epidemiología y Salud Pública (CIBERESP), Public Health Division of Gipuzkoa, Basque Government, CIBER en Salud Pública, CIBERSP, Biodonostia Health Research Institute [Donostia-San Sebastian, Spain] (IIS Biodonostia), Murcia Regional Health Council [Murcia], Universidad de Antioquia = University of Antioquia [Medellín, Colombia], Navarra Public Health Institute, Umeå University, Imperial College London, Kræftens Bekæmpelse, DCS, Deutsches Krebsforschungszentrum, DKFZ, Centre International de Recherche sur le Cancer, CIRC, National Research Council, NRC, University of Maryland School of Public Health, SPH, Cancer Research UK, CRUK, World Cancer Research Fund, WCRF, University of Cambridge, Institut National de la Santé et de la Recherche Médicale, Inserm, Bundesministerium für Bildung und Forschung, BMBF, Cancerfonden, Ministerie van Volksgezondheid, Welzijn en Sport, VWS, Fondation ARC pour la Recherche sur le Cancer, ARC, Ligue Contre le Cancer, Vetenskapsrådet, VR, Instituto de Salud Carlos III, ISCIII, Associazione Italiana per la Ricerca sul Cancro, AIRC, Deutsche Krebshilfe, Institut National Du Cancer, INCa: 2015-166, Institut Gustave-Roussy, Mutuelle Générale de l'Education Nationale, MGEN, NIHR Imperial Biomedical Research Centre, BRC, The national cohorts are supported by Danish Cancer Society (Denmark), Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle Générale de l’Education Nationale, Institut National de la Santé et de la Recherche Médicale (INSERM) (France), German Cancer Aid, German Cancer Research Center (DKFZ), German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Federal Ministry of Education and Research (BMBF) (Germany), Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy, Compagnia di SanPaolo and National Research Council (Italy), Dutch Ministry of Public Health, Welfare and Sports (VWS), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF) (The Netherlands), Health Research Fund (FIS) - Instituto de Salud Carlos III (ISCIII), Regional Governments of Andalucía, Asturias, Basque Country, Murcia and Navarra, and the Catalan Institute of Oncology - ICO (Spain), Swedish Cancer Society, Swedish Research Council and County Councils of Skåne and Västerbotten (Sweden), and Cancer Research UK (14136 to EPIC-Norfolk (DOI 10.22025/2019.10.105.00004), C8221/A29017 to EPIC-Oxford), Medical Research Council (1000143, MR/N003284/1, MC-UU_12015/1 and MC_UU_00006/1 to EPIC-Norfolk, MR/M012190/1 to EPIC-Oxford) (UK). The funders were not involved in designing the study, collecting, analyzing, or interpreting the data, or writing or submitting the manuscript for publication., The coordination of EPIC is financially supported by International Agency for Research on Cancer (IARC) and also by the Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, which has additional infrastructure support provided by the NIHR Imperial Biomedical Research Centre (BRC)., This work was funded by the French National Cancer Institute (grant number 2015-166). Mathilde His’ work reported here was undertaken during the tenure of a postdoctoral fellowship awarded by the International Agency for Research on Cancer, financed by the Fondation ARC., The authors would like to thank Mr Bertrand Hemon for his support in preparing the databases, Ms Audrey Gicquiau and Dr David Achaintre for the analyses of samples in several of the original studies, and all EPIC participants. The EPIC-Norfolk team thank all the participants who have been part of the project and the many members of the study teams at the University of Cambridge who have enabled this research. Where authors are identified as personnel of the International Agency for Research on Cancer/World Health Organization, the authors alone are responsible for the views expressed in this article and they do not necessarily represent the decisions, policy, or views of the International Agency for Research on Cancer/World Health Organization., and HAL UVSQ, Équipe
Subjects: cross-sectional, lifestyle, Estils de vida, BIOMARKERS, Lifestyles, Breast Neoplasms, [SDV.CAN]Life Sciences [q-bio]/Cancer, DIET, SERUM, Càncer de mama, Cohort Studies, Medicine, General & Internal, Breast cancer, [SDV.CAN] Life Sciences [q-bio]/Cancer, Risk Factors, Cross-sectional, General & Internal Medicine, Metabolites, Humans, Metabolomics, Prospective Studies, VALIDITY, Life Style, 11 Medical and Health Sciences, metabolites, RISK, Cancer och onkologi, Science & Technology, anthropometry, Anthropometry, Public Health, Global Health, Social Medicine and Epidemiology, General Medicine, PROFILES, Lifestyle, AMINO-ACID, BODY-MASS INDEX, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, PHYSICAL-ACTIVITY, Cross-Sectional Studies, Metabolòmica, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Cancer and Oncology, TARGETED METABOLOMICS, Medicine, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Life Sciences & Biomedicine, Research Article
Abstract: This work was funded by the French National Cancer Institute (grant number 2015-166). Mathilde His' work reported here was undertaken during the tenure of a postdoctoral fellowship awarded by the International Agency for Research on Cancer, financed by the Fondation ARC. The coordination of EPIC is financially supported by International Agency for Research on Cancer (IARC) and also by the Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, which has additional infrastructure support provided by the NIHR Imperial Biomedical Research Centre (BRC). The national cohorts are supported by Danish Cancer Society (Denmark); Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle Generale de l'Education Nationale, Institut National de la Sante et de la Recherche Medicale (INSERM) (France); German Cancer Aid, German Cancer Research Center (DKFZ), German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Federal Ministry of Education and Research (BMBF) (Germany); Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy, Compagnia di SanPaolo and National Research Council (Italy); Dutch Ministry of Public Health, Welfare and Sports (VWS), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF) (The Netherlands); Health Research Fund (FIS) - Instituto de Salud Carlos III (ISCIII), Regional Governments of Andalucia, Asturias, Basque Country, Murcia and Navarra, and the Catalan Institute of Oncology-ICO (Spain); Swedish Cancer Society, Swedish Research Council and County Councils of Skane and Vasterbotten (Sweden); and Cancer Research UK (14136 to EPIC-Norfolk (DOI 10.22025/2019.10.105.00004); C8221/A29017 to EPIC-Oxford), Medical Research Council (1000143, MR/N003284/1, MC-UU_12015/1 and MC_UU_00006/1 to EPIC-Norfolk; MR/M012190/1 to EPIC-Oxford) (UK). The funders were not involved in designing the study; collecting, analyzing, or interpreting the data; or writing or submitting the manuscript for publication., Background: Metabolomics is a promising molecular tool for identifying novel etiological pathways leading to cancer. In an earlier prospective study among pre- and postmenopausal women not using exogenous hormones, we observed a higher risk of breast cancer associated with higher blood concentrations of one metabolite (acetylcarnitine) and a lower risk associated with higher blood concentrations of seven others (arginine, asparagine, phosphatidylcholines (PCs) aa C36:3, ae C34:2, ae C36:2, ae C36:3, and ae C38:2). Methods: To identify determinants of these breast cancer-related metabolites, we conducted a cross-sectional analysis to identify their lifestyle and anthropometric correlates in 2358 women, who were previously included as controls in case-control studies nested within the European Prospective Investigation into Cancer and Nutrition cohort and not using exogenous hormones at blood collection. Associations of each metabolite concentration with 42 variables were assessed using linear regression models in a discovery set of 1572 participants. Significant associations were evaluated in a validation set (n = 786). Results: For the metabolites previously associated with a lower risk of breast cancer, concentrations of PCs ae C34: 2, C36:2, C36:3, and C38:2 were negatively associated with adiposity and positively associated with total and saturated fat intakes. PC ae C36:2 was also negatively associated with alcohol consumption and positively associated with two scores reflecting adherence to a healthy lifestyle. Asparagine concentration was negatively associated with adiposity. Arginine and PC aa C36:3 concentrations were not associated to any of the factors examined. For the metabolite previously associated with a higher risk of breast cancer, acetylcarnitine, a positive association with age was observed. Conclusions: These associations may indicate possible mechanisms underlying associations between lifestyle and anthropometric factors, and risk of breast cancer. Further research is needed to identify potential non-lifestyle correlates of the metabolites investigated., Institut National du Cancer (INCA) France 2015-166, International Agency for Research on Cancer - Fondation ARC, World Health Organization, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Danish Cancer Society, Ligue Contre le Cancer (France), Institut Gustave Roussy (France), Mutuelle Generale de l'Education Nationale (France), Institut National de la Sante et de la Recherche Medicale (Inserm), Deutsche Krebshilfe, German Cancer Research Center (DKFZ) (Germany), German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE) (Germany), Federal Ministry of Education & Research (BMBF), Fondazione AIRC per la ricerca sul cancro, Compagnia di San Paolo, Consiglio Nazionale delle Ricerche (CNR), Netherlands Government, World Cancer Research Fund International (WCRF), Health Research Fund (FIS) - Instituto de Salud Carlos III (ISCIII) (Spain), Junta de Andalucia, Regional Government of Asturias (Spain), Regional Government of Basque Country (Spain), Regional Government of Murcia (Spain), Regional Government of Navarra (Spain), Catalan Institute of Oncology-ICO (Spain), Swedish Cancer Society, Swedish Research Council, County Council of Skane (Sweden), County Council of Vasterbotten (Sweden), Cancer Research UK 14136 C8221/A29017, UK Research & Innovation (UKRI), Medical Research Council UK (MRC) 1000143 MR/N003284/1 MC-UU_12015/1 MC_UU_00006/1 MR/M012190/1
Published: 2021

34. CRYSTAL23: A Program for Computational Solid State Physics and Chemistry

Author: Alessandro Erba, Jacques K. Desmarais, Silvia Casassa, Bartolomeo Civalleri, Lorenzo Donà, Ian J. Bush, Barry Searle, Lorenzo Maschio, Loredana Edith-Daga, Alessandro Cossard, Chiara Ribaldone, Eleonora Ascrizzi, Naiara L. Marana, Jean-Pierre Flament, Bernard Kirtman, Dipartimento di Chimica, Università degli studi di Torino = University of Turin (UNITO), STFC Rutherford Appleton Laboratory (RAL), Science and Technology Facilities Council (STFC), Dipartimento di Chimica IFM and NIS, Physico-Chimie Moléculaire Théorique (PCMT), Laboratoire de Physique des Lasers, Atomes et Molécules - UMR 8523 (PhLAM), Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Department of Chemistry and Biochemistry [Santa Barbara], University of California [Santa Barbara] (UC Santa Barbara), and University of California (UC)-University of California (UC)
Subjects: [CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry, [PHYS.PHYS.PHYS-CHEM-PH]Physics [physics]/Physics [physics]/Chemical Physics [physics.chem-ph], Physical and Theoretical Chemistry, Computer Science Applications
Abstract: International audience; The Crystal program for quantum-mechanical simulations of materials has been bridging the realm of molecular quantum chemistry to the realm of solid state physics for many years, since its first public version released back in 1988. This peculiarity stems from the use of atom-centered basis functions within a linear combination of atomic orbitals (LCAO) approach and from the corresponding efficiency in the evaluation of the exact Fock exchange series. In particular, this has led to the implementation of a rich variety of hybrid density functional approximations since 1998. Nowadays, it is acknowledged by a broad community of solid state chemists and physicists that the inclusion of a fraction of Fock exchange in the exchange-correlation potential of the density functional theory is key to a better description of many properties of materials (electronic, magnetic, mechanical, spintronic, lattice-dynamical, etc.). Here, the main developments made to the program in the last five years (i.e., since the previous release, Crystal17) are presented and some of their most noteworthy applications reviewed.
Published: 2022

35. Le niveau de biodiversité végétale des prairies modifie les processus digestifs, le microbiote ruminal et des fèces des vaches laitières et la composition du lait

Author: Musati, M., Coppa, M., Delbès, Céline, Verdier-Metz, Isabelle, Popova, Milka, Niderkorn, Vincent, Bouchon, Matthieu, Farizon, Yves, F., Enjalbert, M, Renna, C, Lussiana, Natalello, Antonino, Martin, Bruno, Ferlay, Anne, Unité Mixte de Recherche sur les Herbivores - UMR 1213 (UMRH), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University of Catania [Italy], Unité Mixte de Recherche sur le Fromage (UMRF), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), Unité Expérimentale Systèmes d'Elevage de Ruminants de Moyenne Montagne (Herbipôle), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Génétique Physiologie et Systèmes d'Elevage (GenPhySE ), Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-École nationale supérieure agronomique de Toulouse (ENSAT), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Tissus animaux, nutrition, digestion, écosystème et métabolisme (TANDEM), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université de Toulouse (UT)-Université de Toulouse (UT), Università degli studi di Torino = University of Turin (UNITO), INRAE, and Institut de l'Elevage
Subjects: [SDV]Life Sciences [q-bio]
Abstract: Séance : Alimentation; International audience; To study the interactions between the plant biodiversity of pastures, ruminants, their microbiota and their products, an in vivo and in vitro experiment was carried out in the spring 2018. After a 5-week adaptation period on a common plot, 2 groups of 7 dairy cows were led for 4 weeks on 2 plots with contrasting levels of plant biodiversity: LD (19 species, mainly grasses) and HD (56 species, mostly dicots). Samples of grass selected by the cows (simulated bites), rumen fluid, faeces, and milk were taken at the end of the experimental periods, respectively. Milk production and protein and fat concentration were similar between treatments. The grass from group HD was more fibrous and had a higher total tannin content. Grass total fatty acids (FA) and C18:3 n-3 contents were higher for LD. Total gas production during in vitro ruminal fermentation of HD grass was lower compared to LD, this being probably due to the inhibition of bacterial proliferation by tannins, which also protected the digestion of the dry matter of the HD group compared to LD. Ruminal fluid of HD cows differed from that of LD cows by a lower concentration of total FA but a higher proportion of polyunsaturated fatty acids (PUFA). This suggests a less complete biohydrogenation of dietary PUFA induced by tannins. The β-diversity, which considers the equipartition of species, showed differences between the bacterial and fungal communities of the ruminal liquid and the faeces of the cows between the 2 treatments. The FA profile of milk from LD cows is distinguished by a higher concentration of C18:2 c9t11. Moreover, the quantity of C18:3 n-3 is not significantly different between the treatments, despite the marked differences on grass. The lower total FA and n-3 content of the grass from the HD group could have been compensated by the protective role of tannins in the rumen.; Pour étudier les interactions entre la biodiversité végétale des prairies, les ruminants, leur microbiote et leurs produits, des expérimentations in vivo et in vitro ont été menées au printemps 2018. Après une période d’adaptation de 5 semaines sur une parcelle commune, 2 lots de 7 vaches laitières ont été conduits pendant 4 semaines sur 2 parcelles présentant des niveaux de biodiversité végétale contrastés : LD (diversité flaible,19 espèces, beaucoup des graminées) et HD (diversité élevée 56 espèces, beaucoup des dicotylédones). Des prélèvements d’herbe sélectionnés par les vaches (bouchées simulées), de liquide ruminal, de fèces et de lait ont été réalisés en fin de période d’adaptation, et en fin de période expérimentale. La production laitière et les taux protéique et butyreux était similaires entre les lots. L'herbe du lot HD était plus fibreuse et avait une teneur en tanins totaux plus élevée. La teneur en acides gras (AG) totaux de l’herbe, et en C18:3 n3, était plus élevée pour LD. La production totale de gaz lors de la fermentation ruminale in vitro de l’herbe HD était plus faible par rapport à LD, ceci étant probablement dû à l’inhibition de l’activité bactérienne par les tanins, qui ont également protégé la digestion de la matière sèche (MS) du lot HD par rapport au lot LD. Le liquide ruminal des vaches HD a présenté une concentration plus faible en AG totaux mais une proportion plus élevée en acides gras polyinsaturés (AGPI). Cela suggère une biohydrogénation moins complète des AGPI alimentaires induite par les tanins. La β-diversité, qui considère l’équipartition des espèces, a montré des différences entre des communautés bactériennes et fongiques du liquide ruminal et des fèces des vaches entre les 2 lots. Le profil en AG du lait des vaches LD se distingue par une concentration plus importante en C18:2 c9t11. Par contre, la quantité de C18:3 n-3 n’est pas significativement différente entre les lots, malgré les différences marquées sur l’herbe. Le contenu en AG totaux et en n-3 plus faible de l’herbe du lot HD, pourrait avoir été compensé par l’effet protecteur des tanins dans le rumen.
Published: 2022

36. An iterative and interdisciplinary categorisation process towards FAIRer digital resources for sensitive life-sciences data

Author: Romain David, Christian Ohmann, Jan-Willem Boiten, Mónica Cano Abadía, Florence Bietrix, Steve Canham, Maria Luisa Chiusano, Walter Dastrù, Arnaud Laroquette, Dario Longo, Michaela Th. Mayrhofer, Maria Panagiotopoulou, Audrey S. Richard, Sergey Goryanin, Pablo Emilio Verde, European Research Infrastructure on Highly Pathogenic Agents (ERINHA-AISBL), European Clinical Research Infrastructures Network [Dusseldorf] (ECRIN), European Advanced Translational Research Infrastructure (EATRIS), European research infrastructure for biobanking (BBMRI-ERIC), University of Naples Federico II = Università degli studi di Napoli Federico II, Stazione Zoologica Anton Dohrn (SZN), Università degli studi di Torino = University of Turin (UNITO), European Marine Biological Resource Centre (EMBRC-ERIC), Institute of biostructures and bioimaging (IBB), National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR), Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf], This project has received funding from the European Union’s Horizon 2020 research and innovation programme 'EOSC-Life—Providing an open collaborative space for digital biology in Europe' under Grant agreement No 824087., and European Project: 824087,EOSC-Life
Subjects: vision, data sharing, [SDV]Life Sciences [q-bio], biomedicine, Pilot Projects, tagging, Biological Science Disciplines, interdisciplinarity, ACM: H.: Information Systems, life cycle, toolbox, human, EOSC-Life, adoption, FAIR, filtration, Multidisciplinary, life sciences, pilot study, Software, article, software, usability, MESH: Biochemistry, Computational biology and bioinformatics, Ecology, Genetics, Medical research, Microbiology Molecular biology, Natural hazards, Plant sciences, Zoology, ACM: K.: Computing Milieux, categorisation, [SDE]Environmental Sciences, Sensitive data
Abstract: International audience; For life science infrastructures, sensitive data generate an additional layer of complexity. Crossdomain categorisation and discovery of digital resources related to sensitive data presents major interoperability challenges. To support this FAIRification process, a toolbox demonstrator aiming at support for discovery of digital objects related to sensitive data (e.g., regulations, guidelines, best practice, tools) has been developed. The toolbox is based upon a categorisation system developed and harmonised across a cluster of 6 life science research infrastructures. Three different versions were built, tested by subsequent pilot studies, finally leading to a system with 7 main categories (sensitive data type, resource type, research field, data type, stage in data sharing life cycle, geographical scope, specific topics). 109 resources attached with the tags in pilot study 3 were used as the initial content for the toolbox demonstrator, a software tool allowing searching of digital objects linked to sensitive data with filtering based upon the categorisation system. Important next steps are a broad evaluation of the usability and user-friendliness of the toolbox, extension to more resources, broader adoption by different life-science communities, and a long-term vision for maintenance and sustainability.; Pour les infrastructures des sciences de la vie, les données sensibles génèrent une couche supplémentaire de complexité. La catégorisation et la découverte inter-domaines des ressources numériques liées aux données sensibles présentent des défis majeurs en matière d'interopérabilité. Pour soutenir ce processus de FAIRification, un démonstrateur de "boîte à outils" visant à soutenir la découverte d'objets numériques liés à des données sensibles (par exemple, réglementations, directives, bonnes pratiques, outils) a été développé. La boîte à outils est basée sur un système de catégorisation développé et harmonisé à travers un groupe de 6 infrastructures de recherche en sciences de la vie. Trois versions différentes ont été construites, testées par des études pilotes successives, aboutissant finalement à un système avec 7 catégories principales (type de données sensibles, type de ressource, domaine de recherche, type de données, étape du cycle de vie du partage de données, portée géographique, sujets spécifiques). 109 ressources attachées aux tags de la dernière étude pilote ont servi de contenu initial au démonstrateur de l'outil, permettant la recherche d'objets numériques liés à des données sensibles avec un filtrage basé sur le système de catégorisation. Les prochaines étapes concernent l'évaluation globale de l'utilisabilité et de la "convivialité" de la boîte à outils, une extension à davantage de ressources, une adoption plus large par différentes communautés des sciences de la vie pour les tests et une projection à long terme concernant la maintenance et la durabilité.
Published: 2022

37. EXpert consensus On Diaphragm UltraSonography in the critically ill (EXODUS): a Delphi consensus statement on the measurement of diaphragm ultrasound-derived parameters in a critical care setting

Author: Mark E. Haaksma, Jasper M. Smit, Alain Boussuges, Alexandre Demoule, Martin Dres, Giovanni Ferrari, Paolo Formenti, Ewan C. Goligher, Leo Heunks, Endry H. T. Lim, Lidwine B. Mokkink, Eleni Soilemezi, Zhonghua Shi, Michele Umbrello, Luigi Vetrugno, Emmanuel Vivier, Lei Xu, Massimo Zambon, Pieter R. Tuinman, Intensive care medicine, Radiology and nuclear medicine, Epidemiology and Data Science, APH - Methodology, ACS - Diabetes & metabolism, ACS - Pulmonary hypertension & thrombosis, Amsterdam UMC - Amsterdam University Medical Center, Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Hôpital Nord [CHU - APHM], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Neurophysiologie Respiratoire Expérimentale et Clinique (UMRS 1158), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Mauriziano Umberto Hospital [Turin, Italy] (MUH), Ospedale San Paolo, Partenaires INRAE, University of Toronto, University Health Network, Toronto General Hospital Research Institute [Canada] (TGHRI), Erasmus University Medical Center [Rotterdam] (Erasmus MC), Vrije Universiteit Amsterdam [Amsterdam] (VU), Papageorgiou General Hospital, AO 'Ospedale San Carlo Borromeo', University 'G. d'Annunzio' of Chieti-Pescara [Chieti], SS Annunziata Hospital, Centre hospitalier Saint Joseph - Saint Luc [Lyon], Graduate School, Intensive Care Medicine, Service de Médecine Intensive et Réanimation - R3S [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Sorbonne Université (SU), Department of Medical Sciences [Turin, Italy] (DMS), Università degli studi di Torino = University of Turin (UNITO), VU University Medical Center [Amsterdam], Aristotle University of Thessaloniki, Capital University of Medical Sciences [Beijing] (CUMS), Ospedale San Paolo-Polo Universitario, ASST Santi Paolo e Carlo, Milan, Università degli studi 'G. d'Annunzio' Chieti-Pescara [Chieti-Pescara] (Ud'A), Chongqing University [Chongqing], Università degli Studi di Milano = University of Milan (UNIMI), Lucas, Nelly, and Internal Medicine
Subjects: [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Consensus, Critical Care, Delphi Technique, Critical Illness, [SDV]Life Sciences [q-bio], Diaphragm, Ultrasound, Humans, Critical Care and Intensive Care Medicine, Delphi, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Ultrasonography
Abstract: Background Diaphragm ultrasonography is rapidly evolving in both critical care and research. Nevertheless, methodologically robust guidelines on its methodology and acquiring expertise do not, or only partially, exist. Therefore, we set out to provide consensus-based statements towards a universal measurement protocol for diaphragm ultrasonography and establish key areas for research. Methods To formulate a robust expert consensus statement, between November 2020 and May 2021, a two-round, anonymous and online survey-based Delphi study among experts in the field was performed. Based on the literature review, the following domains were chosen: “Anatomy and physiology”, “Transducer Settings”, “Ventilator Impact”, “Learning and expertise”, “Daily practice” and “Future directions”. Agreement of ≥ 68% (≥ 10 panelists) was needed to reach consensus on a question. Results Of 18 panelists invited, 14 agreed to participate in the survey. After two rounds, the survey included 117 questions of which 42 questions were designed to collect arguments and opinions and 75 questions aimed at reaching consensus. Of these, 46 (61%) consensus was reached. In both rounds, the response rate was 100%. Among others, there was agreement on measuring thickness between the pleura and peritoneum, using > 10% decrease in thickness as cut-off for atrophy and using 40 examinations as minimum training to use diaphragm ultrasonography in clinical practice. In addition, key areas for research were established. Conclusion This expert consensus statement presents the first set of consensus-based statements on diaphragm ultrasonography methodology. They serve to ensure high-quality and homogenous measurements in daily clinical practice and in research. In addition, important gaps in current knowledge and thereby key areas for research are established. Trial registration The study was pre-registered on the Open Science Framework with registration digital object identifier https://doi.org/10.17605/OSF.IO/HM8UG.
Published: 2022

38. Decreased brain network global efficiency after attachment memories retrieval in individuals with unresolved/disorganized attachment-related state of mind

Author: Chiara Massullo, Claudio Imperatori, Fabrizio De Vico Fallani, Rita B. Ardito, Mauro Adenzato, Luigia Palmiero, Giuseppe Alessio Carbone, Benedetto Farina, Università degli Studi Roma Tre = Roma Tre University (ROMA TRE), European University of Rome (EUR), Algorithms, models and methods for images and signals of the human brain (ARAMIS), Sorbonne Université (SU)-Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Università degli studi di Torino = University of Turin (UNITO), Tis study was supported by Ministero dell’Istruzione, dell’Università e della Ricerca—MIUR project 'Dipartimenti di Eccellenza 2018–2022' to Department of Neuroscience 'Rita Levi Montalcini'. M.A. and R.B.A. were supported by University of Turin grants ('Ricerca scientifca fnanziata dall’Università')., and De Vico Fallani, Fabrizio
Subjects: Adult, [SDV.IB] Life Sciences [q-bio]/Bioengineering, Multidisciplinary, Parenting, Organized, Brain, Electroencephalography, Object Attachment, Adult Attachment Interview, Organized, Disorganized, Unresolved, Network analysis, Functional connectivity, Electroencephalography, Functional connectivity, Memory, Unresolved, Humans, Network analysis, [SDV.IB]Life Sciences [q-bio]/Bioengineering, Disorganized, Adult Attachment Interview
Abstract: The main aim of the study was to examine how brain network metrics change after retrieval of attachment memories in individuals with unresolved/disorganized (U/D) attachment-related state of mind and those with organized/resolved (O/R) state of mind. We focused on three main network metrics associated with integration and segregation: global (Eglob) efficiency for the first function, local (Eloc) efficiency and modularity for the second. We also examined assortativity and centrality metrics. Electroencephalography (EEG) recordings were performed before and after the Adult Attachment Interview (AAI) in a sample of 50 individuals previously assessed for parenting quality. Functional connectivity matrices were constructed by means of the exact Low-Resolution Electromagnetic Tomography (eLORETA) software and then imported into MATLAB to compute brain network metrics. Compared to individuals with O/R attachment-related state of mind, those with U/D show a significant decrease in beta Eglob after AAI. No statistically significant difference among groups emerged in Eloc and modularity metrics after AAI, neither in assortativity nor in betweenness centrality. These results may help to better understand the neurophysiological patterns underlying the disintegrative effects of retrieving traumatic attachment memories in individuals with disorganized state of mind in relation to attachment.
Published: 2022

39. MYC and MET cooperatively drive hepatocellular carcinoma with distinct molecular traits and vulnerabilities

Author: Celia Sequera, Margherita Grattarola, Agnes Holczbauer, Rosanna Dono, Stefania Pizzimenti, Giuseppina Barrera, Kirk J. Wangensteen, Flavio Maina, Institut de Biologie du Développement de Marseille (IBDM), Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Medicina e Oncologia Sperimentale, Università degli studi di Torino = University of Turin (UNITO), and University of Pennsylvania
Subjects: Proto-Oncogene Proteins c-myc, Cancer Research, Cellular and Molecular Neuroscience, Carcinoma, Hepatocellular, Glypicans, Carcinogenesis, [SDV]Life Sciences [q-bio], Liver Neoplasms, Immunology, Hepatocytes, Humans, Cell Biology
Abstract: Enhanced activation of the transcription factor MYC and of the receptor tyrosine kinase MET are among the events frequently occurring in hepatocellular carcinoma (HCC). Both genes individually act as drivers of liver cancer initiation and progression. However, their concomitant alteration in HCC has not been explored, nor functionally documented. Here, we analysed databases of five independent human HCC cohorts and found a subset of patients with high levels of MYC and MET (MYChigh/METhigh) characterised by poor prognosis. This clinical observation drove us to explore the functionality of MYC and MET co-occurrence in vivo, combining hydrodynamic tail vein injection for MYC expression in the R26stopMet genetic setting, in which wild-type MET levels are enhanced following the genetic deletion of a stop cassette. Results showed that increased MYC and MET expression in hepatocytes is sufficient to induce liver tumorigenesis even in the absence of pre-existing injuries associated with a chronic disease state. Intriguingly, ectopic MYC in MET tumours increases expression of the Mki67 proliferation marker, and switches them into loss of Afp, Spp1, Gpc3, Epcam accompanied by an increase in Hgma1, Vim, and Hep-Par1 levels. We additionally found a switch in the expression of specific immune checkpoints, with an increase in the Ctla-4 and Lag3 lymphocyte co-inhibitory responses, and in the Icosl co-stimulatory responses of tumour cells. We provide in vitro evidence on the vulnerability of some human HCC cell lines to combined MYC and MET targeting, which are otherwise resistant to single inhibition. Mechanistically, combined blockage of MYC and MET converts a partial cytostatic effect, triggered by individual blockage of MYC or MET, into a cytotoxic effect. Together, these findings highlight a subgroup of HCC characterised by MYChigh/METhigh, and document functional cooperativity between MYC and MET in liver tumorigenesis. Thus, the MYC-R26Met model is a relevant setting for HCC biology, patient classification and treatment.
Published: 2022

40. Sequencing and Titrating Approach of Therapy in Heart Failure with Reduced Ejection Fraction Following the 2021 ESC guidelines: an International Cardiology Survey

Author: Fauvel, Charles, Bonnet, Guillaume, Mullens, Wilfried, Giraldo, Clara Ines Saldarriaga, Mežnar, Anja Zupan, Barasa, Anders, Tokmakova, Mariya, Shchendrygina, Anastasia, Costa, Francisco Moscoso, Mapelli, Massimo, Zemrak, Filip, Tops, Laurens, Jakus, Nina, Sultan, Arian, Bahouth, Fadel, Hadjseyd, Chahr‐eddine, Salvat, Muriel, Anselmino, Matteo, Messroghli, Daniel, Weberndörfer, Vanessa, Giverts, Ilya, Bochaton, Thomas, Berthelot, Emmanuelle, Legallois, Damien, Beauvais, Florence, Bauer, Fabrice, Lamblin, Nicolas, Damy, Thibaud, Girerd, Nicolas, Sebbag, Laurent, Pezel, Théo, Cohen-Solal, Alain, Rosano, Giuseppe, Roubille, François, Mewton, Nathan, CHU Rouen, Normandie Université (NU), Ohio State University [Columbus] (OSU), Hôpital Haut-Lévêque [CHU Bordeaux], CHU Bordeaux [Bordeaux], Ziekenhuis Oost-Limburg (ZOL), Hasselt University (UHasselt), Universidad Pontificia Bolivariana (UPB), University Medical Centre Ljubljana [Ljubljana, Slovenia] (UMCL), Glostrup Hospital, Medical University of Plovdiv, Sechenov First Moscow State Medical University, Hospital de Santa Cruz, Centro Cardiologico Monzino [Milano], Dpt di Scienze Cliniche e di Comunità [Milano] (DISCCO), Università degli Studi di Milano = University of Milan (UNIMI)-Università degli Studi di Milano = University of Milan (UNIMI)-Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS), Università degli Studi di Milano = University of Milan (UNIMI), St Bartholomew's Hospital (London), Leiden University Medical Center (LUMC), Universiteit Leiden, University Hospital Centre Zagreb, Partenaires INRAE, Universitätsklinikum Köln (Uniklinik Köln), Bnai Zion Hospital, Centre d'Investigation Clinique [Bron] (CIC1407), Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Groupement Hospitalier Est [Bron], Hôpital Louis Pradel [CHU - HCL], Hospices Civils de Lyon (HCL), CHU Grenoble, Università degli studi di Torino = University of Turin (UNITO), German Heart Institute Berlin [Berlin, Germany] (GHIB), Cardiovascular Research Institute Maastricht (CARIM), Maastricht University [Maastricht], Maastricht University Medical Centre (MUMC), Massachusetts General Hospital [Boston], AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Service de cardiologie et de pathologie vasculaire [CHU Caen], Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Marqueurs cardiovasculaires en situation de stress (MASCOT (UMR_S_942 / U942)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Hôpital Charles Nicolle [Rouen], Normandie Université (NU)-Normandie Université (NU), CHU Lille, Université de Lille, Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP), CHU Henri Mondor [Créteil], Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] (CIC-P), Centre d'investigation clinique [Nancy] (CIC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] (INI-CRCT), Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu [Nancy], Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS San Raffaele Pisana), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), and Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)
Subjects: Pharmacology, Treatment, [SDV]Life Sciences [q-bio], Heart failure, Guideline
Abstract: International audience; Aims: In symptomatic patients with heart failure and reduced ejection fraction (HFrEF), recent international guidelines recommend initiating four major therapeutic classes rather than sequential initiation. It remains unclear how this change in guidelines is perceived by practicing cardiologists versus heart failure (HF) specialists.Methods and results: An independent academic web-based survey was designed by a group of HF specialists and posted by email and through various social networks to a broad community of cardiologists worldwide 1 year after the publication of the latest European HF guidelines. Overall, 615 cardiologists (38 [32-47] years old, 63% male) completed the survey, of which 58% were working in a university hospital and 26% were HF specialists. The threshold to define HFrEF was ≤40% for 61% of the physicians. Preferred drug prescription for the sequential approach was angiotensin-converting enzyme inhibitors or angiotensin receptor-neprilysin inhibitors first (74%), beta-blockers second (55%), mineralocorticoid receptor antagonists third (52%), and sodium-glucose cotransporter 2 inhibitors (53%) fourth. Eighty-four percent of participants felt that starting all four classes was feasible within the initial hospitalization, and 58% felt that titration is less important than introducing a new class. Age, status in training, and specialization in HF field were the principal characteristics that significantly impacted the answers.Conclusion: In a broad international cardiology community, the 'historical approach' to HFrEF therapies remains the preferred sequencing approach. However, accelerated introduction and uptitration are also major treatment goals. Strategy trials in treatment guidance are needed to further change practices.
Published: 2022

41. ONE-DIMENSIONAL INELASTIC BOLTZMANN EQUATION: REGULARITY & UNIQUENESS OF SELF-SIMILAR PROFILES FOR MODERATELY HARD POTENTIALS

Author: Alonso, Ricardo J., Bagland, Véronique, Cañizo, José A., Lods, Bertrand, Throm, Sebastian, Texas A&M University at Qatar, Université Clermont Auvergne (UCA), Universidad de Granada = University of Granada (UGR), Università degli studi di Torino = University of Turin (UNITO), and Umeå University
Subjects: Mathematics - Analysis of PDEs, [MATH.MATH-MP]Mathematics [math]/Mathematical Physics [math-ph], FOS: Mathematics, FOS: Physical sciences, [MATH.MATH-AP]Mathematics [math]/Analysis of PDEs [math.AP], Mathematical Physics (math-ph), Mathematical Physics, Analysis of PDEs (math.AP)
Abstract: We prove uniqueness of self-similar profiles for the one-dimensional inelastic Boltzmann equation with moderately hard potentials, that is with collision kernel of the form | $\bullet$ | $\gamma$ for $\gamma$ > 0 small enough (explicitly quantified). Our result provides the first uniqueness statement for self-similar profiles of inelastic Boltzmann models allowing for strong inelasticity besides the explicitly solvable case of Maxwell interactions (corresponding to $\gamma$ = 0). Our approach relies on a perturbation argument from the corresponding Maxwell model through a careful study of the associated linearised operator. In particular, a part of the paper is devoted to the trend to equilibrium for the Maxwell model in suitable weighted Sobolev spaces, an extension of results which are known to hold in weaker topologies. Our results can be seen as a first step towards a full proof, in the one-dimensional setting, of a conjecture in Ernst \& Brito (2002) regarding the determination of the long-time behaviour of solutions to inelastic Boltzmann equation.
Published: 2022

42. Radiation tolerance of diamond detectors

Author: Bäni, L, Artuso, M, Bachmair, F, Bartosik, M, Beck, H, Bellini, V, Belyaev, V, Bentele, B, Bergonzo, P, Bes, A, Brom, J-M, Chiodini, G, Chren, D, Cindro, V, Claus, G, Collot, J, Cumalat, J, Curtoni, S, Dabrowski, A, D'Alessandro, R, Dauvergne, D, de Boer, W, Dorfer, C, Dünser, M, Eigen, G, Eremin, V, Forneris, J, Gallin-Martel, L, Gallin-Martel, M-L, Gan, K K, Gastal, M, Ghimouz, A, Goffe, M, Goldstein, J, Golubev, A, Gorišek, A, Grigoriev, E, Grosse-Knetter, J, Grummer, A, Hiti, B, Hits, D, Hoeferkamp, M, Hofmann, T, Hosselet, J, Hügging, F, Hutson, C, Jackman, R, Janssen, J, Jennings-Moors, R, Kagan, H, Kanxheri, K, Kis, M, Kramberger, G, Kuleshov, S, Lacoste, A, Lagomarsino, S, Lo Giudice, A, Paz, I López, Lukosi, E, Maazouzi, C, Mandić, I, Marcatili, S, Marino, A, Mathieu, C, Menichelli, M, Mikuž, M, Morozzi, A, Moscatelli, F, Moss, J, Mountain, R, Oh, A, Olivero, P, Pakpour-Tabrizi, A, Passeri, D, Pernegger, H, Perrino, R, Picollo, F, Pomorski, M, Porter, A, Potenza, R, Quadt, A, Rarbi, F, Re, A, Reichmann, M, Roe, S, Rossetto, O, Becerra, D A Sanz, Schmidt, C, Schnetzer, S, Sciortino, S, Scorzoni, A, Seidel, S, Servoli, L, Smith, D S, Sopko, B, Sopko, V, Spagnolo, S, Spanier, S, Stenson, K, Stone, R, Stugu, B, Sutera, C, Traeger, M, Trischuk, W, Truccato, M, Tuvê, C, Velthuis, J, Wagner, S, Wallny, R, Wang, J C, Welch, J, Wermes, N, Wickramasinghe, J, Yamouni, M, Zalieckas, J, Zavrtanik, M, Departement Physik [ETH Zürich] (D-PHYS), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Syracuse University, CERN [Genève], Georg-August-University = Georg-August-Universität Göttingen, Istituto Nazionale di Fisica Nucleare, Sezione di Catania (INFN), Università degli studi di Catania = University of Catania (Unict), Moscow State Engineering Physics Institute (MEPhI), University of Colorado [Colorado Springs] (UCCS), University College of London [London] (UCL), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Istituto Nazionale di Fisica Nucleare, Sezione di Lecce (INFN, Sezione di Lecce), Istituto Nazionale di Fisica Nucleare (INFN), Czech Technical University in Prague (CTU), Jozef Stefan Institute [Ljubljana] (IJS), Istituto Nazionale di Fisica Nucleare [Ferrara] (INFN), Universität Karlsruhe (TH), Department of Physics [ETH Zürich] (D-PHYS), University of Bergen (UiB), A.F. Ioffe Physical-Technical Institute, Russian Academy of Sciences [Moscow] (RAS), Università degli studi di Torino = University of Turin (UNITO), Ohio State University [Columbus] (OSU), University of Bristol [Bristol], Institute of Theoretical and Experimental Physics [Moscow] (ITEP), National Research Center 'Kurchatov Institute' (NRC KI), The University of New Mexico [Albuquerque], Rheinische Friedrich-Wilhelms-Universität Bonn, Istituto Nazionale di Fisica Nucleare, Sezione di Perugia (INFN, Sezione di Perugia), GSI Helmholtzzentrum für Schwerionenforschung (GSI), Istituto Nazionale di Fisica Nucleare, Sezione di Firenze (INFN, Sezione di Firenze), University of Manchester [Manchester], The University of Tennessee [Knoxville], University of Colorado [Boulder], California State University [Sacramento], Laboratoire Capteurs Diamant (LCD-LIST), Département Métrologie Instrumentation & Information (DM2I), Laboratoire d'Intégration des Systèmes et des Technologies (LIST (CEA)), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Laboratoire d'Intégration des Systèmes et des Technologies (LIST (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Rutgers University [Camden], Rutgers University System (Rutgers), University of Toronto, RD42 Collaboration, and European Project: 654168,H2020,H2020-INFRAIA-2014-2015,AIDA-2020(2015)
Subjects: instrumentation, History, chemical vapour deposition (CVD), detector, protons, irradiation, neutrons, radiation tolerance, electrode, polycrystalline, Computer Science Applications, Education, radiation, diamond, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Detectors and Experimental Techniques, pions, ionizing radiation, nuclear instrumentation
Abstract: International audience; Diamond is used as detector material in high energy physics experiments due to its inherent radiation tolerance. The RD42 collaboration has measured the radiation tolerance of chemical vapour deposition (CVD) diamond against proton, pion, and neutron irradiation. Results of this study are summarized in this article. The radiation tolerance of diamond detectors can be further enhanced by using a 3D electrode geometry. We present preliminary results of a poly-crystalline CVD (pCVD) diamond detector with a 3D electrode geometry after irradiation and compare to planar devices of roughly the same thickness.
Published: 2022

43. Towards EXtreme scale technologies and accelerators for euROhpc hw/Sw supercomputing applications for exascale: The TEXTAROSSA approach

Author: Giovanni Agosta, Marco Aldinucci, Carlos Alvarez, Roberto Ammendola, Yasir Arfat, Olivier Beaumont, Massimo Bernaschi, Andrea Biagioni, Tommaso Boccali, Berenger Bramas, Carlo Brandolese, Barbara Cantalupo, Mauro Carrozzo, Daniele Cattaneo, Alessandro Celestini, Massimo Celino, Iacopo Colonnelli, Paolo Cretaro, Pasqua D’Ambra, Marco Danelutto, Roberto Esposito, Lionel Eyraud-Dubois, Antonio Filgueras, William Fornaciari, Ottorino Frezza, Andrea Galimberti, Francesco Giacomini, Brice Goglin, Daniele Gregori, Abdou Guermouche, Francesco Iannone, Michal Kulczewski, Francesca Lo Cicero, Alessandro Lonardo, Alberto R. Martinelli, Michele Martinelli, Xavier Martorell, Giuseppe Massari, Simone Montangero, Gianluca Mittone, Raymond Namyst, Ariel Oleksiak, Paolo Palazzari, Pier Stanislao Paolucci, Federico Reghenzani, Cristian Rossi, Sergio Saponara, Francesco Simula, Federico Terraneo, Samuel Thibault, Massimo Torquati, Matteo Turisini, Piero Vicini, Miquel Vidal, Davide Zoni, Giuseppe Zummo, Politecnico di Milano [Milan] (POLIMI), Università degli studi di Torino = University of Turin (UNITO), Barcelona Supercomputing Center - Centro Nacional de Supercomputacion (BSC - CNS), Istituto Nazionale di Fisica Nucleare, Sezione di Roma Tor Vergata (INFN, Sezione di Roma Tor Vergata), Istituto Nazionale di Fisica Nucleare (INFN), High-End Parallel Algorithms for Challenging Numerical Simulations (HiePACS), Laboratoire Bordelais de Recherche en Informatique (LaBRI), Université de Bordeaux (UB)-École Nationale Supérieure d'Électronique, Informatique et Radiocommunications de Bordeaux (ENSEIRB)-Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB)-École Nationale Supérieure d'Électronique, Informatique et Radiocommunications de Bordeaux (ENSEIRB)-Centre National de la Recherche Scientifique (CNRS)-Inria Bordeaux - Sud-Ouest, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Istituto per le Applicazioni del Calcolo 'Mauro Picone' (IAC), National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR), Istituto Nazionale di Fisica Nucleare, Sezione di Roma 3 (INFN, Sezione di Roma 3), Compilation pour les Architectures MUlti-coeurS (CAMUS), Inria Nancy - Grand Est, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie (ICube), École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Université de Strasbourg (UNISTRA)-Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Les Hôpitaux Universitaires de Strasbourg (HUS)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Université de Strasbourg (UNISTRA)-Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Les Hôpitaux Universitaires de Strasbourg (HUS)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Istituto Nazionale di Fisica Nucleare [Pisa] (INFN), Agenzia Nazionale per le nuove Tecnologie, l’energia e lo sviluppo economico sostenibile = Italian National Agency for New Technologies, Energy and Sustainable Economic Development (ENEA), University of Pisa - Università di Pisa, Topology-Aware System-Scale Data Management for High-Performance Computing (TADAAM), Poznan Supercomputing and Networking Center (PSNC), Istituto Nazionale di Fisica Nucleare [Sezione di Roma 1] (INFN), Istituto Nazionale di Fisica Nucleare, Università degli Studi di Padova = University of Padua (Unipd), STatic Optimizations, Runtime Methods (STORM), European Project: 956831,TEXTAROSSA(2021), Universitat Politècnica de Catalunya. Departament d'Arquitectura de Computadors, Universitat Politècnica de Catalunya. Doctorat en Arquitectura de Computadors, Barcelona Supercomputing Center, and Universitat Politècnica de Catalunya. CAP - Grup de Computació d'Altes Prestacions
Subjects: thermal and power management, Computer Networks and Communications, Energia -- Consum, exascale computing, thermal and power management, euroHPC, euroHPC, Energy consumption, exascale computing, Artificial Intelligence, Hardware and Architecture, [INFO]Computer Science [cs], High performance computing, High-performance computing, Informàtica::Arquitectura de computadors [Àrees temàtiques de la UPC], Càlcul intensiu (Informàtica), Software
Abstract: In the near future, Exascale systems will need to bridge three technology gaps to achieve high performance while remaining under tight power constraints: energy efficiency and thermal control; extreme computation efficiency via HW acceleration and new arithmetic; methods and tools for seamless integration of reconfigurable accelerators in heterogeneous HPC multi-node platforms. TEXTAROSSA addresses these gaps through a co-design approach to heterogeneous HPC solutions, supported by the integration and extension of HW and SW IPs, programming models, and tools derived from European research. This work is supported by the TEXTAROSSA project (G.A. n. 956831), as part of the EuroHPC initiative. Peer Reviewed Article signat per 56 autors/es: Giovanni Agosta (a) , Marco Aldinucci (f) , Carlos Alvarez (h) , Roberto Ammendola (n) , Yasir Arfat (f) , Olivier Beaumont (g) , Massimo Bernaschi (c) , Andrea Biagioni (j) , Tommaso Boccali (l) , Berenger Bramas (g) , Carlo Brandolese (a) , Barbara Cantalupo (f) , Mauro Carrozzo (c) , Daniele Cattaneo (a) , Alessandro Celestini (c) , Massimo Celino (b) , Iacopo Colonnelli (f) , Paolo Cretaro (j) , Pasqua D’Ambra (d) , Marco Danelutto (e) , Roberto Esposito (f) , Lionel Eyraud-Dubois (g) , Antonio Filgueras (h) , William Fornaciari (a) , Ottorino Frezza (j) , Andrea Galimberti (a) , Francesco Giacomini (k) , Brice Goglin (g) , Daniele Gregori (o) , Abdou Guermouche (g) , Francesco Iannone (b) , Michal Kulczewski (i) , Francesca Lo Cicero (j) , Alessandro Lonardo (j) , Alberto R. Martinelli (f) , Michele Martinelli (j) , Xavier Martorell (h) , Giuseppe Massari (a) , Simone Montangero (m), Gianluca Mittone (f) , Raymond Namyst (g) , Ariel Oleksiak (i) , Paolo Palazzari (b) , Pier Stanislao Paolucci (j) , Federico Reghenzani (a)∗ , Cristian Rossi (j) , Sergio Saponara (e) , Francesco Simula (j) , Federico Terraneo (a) , Samuel Thibault (g) , Massimo Torquati (e) , Matteo Turisini (j) , Piero Vicini (j) , Miquel Vidal (h) , Davide Zoni (a) , Giuseppe Zummo (b) // (a) Politecnico di Milano, Dipartimento di Elettronica, Informazione e Bioingegneria, Italy; (b) ENEA, Agenzia nazionale per le nuove tecnologie, l’energia e lo sviluppo economico sostenibile, Italy; (c) Istituto per le Applicazioni del Calcolo (IAC), Consiglio Nazionale delle Ricerche, Rome, Italy; (d) Istituto per le Applicazioni del Calcolo (IAC), Consiglio Nazionale delle Ricerche, Naples, Italy; (e) University of Pisa, Italy; (f) University of Torino, Italy; (g) Institut national de recherche en informatique et en automatique (Inria), France; (h) Barcelona Supercomputing Center, Spain; (i) Poznan Supercomputing and Networking Center, Poland; (j) Istituto Nazionale di Fisica Nucleare, Sezione di Roma, Italy; (k) Istituto Nazionale di Fisica Nucleare, CNAF, Italy; (l) Istituto Nazionale di Fisica Nucleare, Sezione di Pisa, Italy; (m) University of Padova and Istituto Nazionale di Fisica Nucleare Sezione di Padova, Italy; (n) Istituto Nazionale di Fisica Nucleare, Sezione di Roma Tor Vergata, Italy; (o) E4 Computer Engineering Spa, Italy
Published: 2022

44. Brain Endothelial Cells Control Fertility through Ovarian-Steroid–Dependent Release of Semaphorin 3A

Author: Paolo Giacobini, Naresh Kumar Hanchate, Joost Verhaagen, Luca Tamagnone, Danièle Mazur, Jyoti Parkash, Gabriella Cagnoni, Barbara Hobo, Filippo Casoni, Sebastien G. Bouret, Fanny Langlet, Sarah Gallet, Massimiliano Mazzone, Andrea Messina, Vincent Prevot, Masahiko Taniguchi, Charlotte Vanacker, Céline Campagne, Philippe Ciofi, Development and Plasticity of the Postnatal Brain [Lille], Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U1172 Inserm - U837 (JPArc), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Lille Nord de France (COMUE)-Université de Lille-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Lille Nord de France (COMUE)-Université de Lille, Institut de médecine predictive et de recherche thérapeutique (IMPRT), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] (UNICANCER/Lille), Université Lille Nord de France (COMUE)-UNICANCER-Université Lille Nord de France (COMUE)-UNICANCER-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Unité de Soins de Longue Durée [USLD - Nord, Lille] (Ecole de Médecine), Hôpital Gériatrique Les Bateliers [Lille] (USLD - Nord), Netherlands Institute for Neuroscience (NIN), Royal Netherlands Academy of Arts and Sciences (KNAW), Center for Neurogenomics and Cognitive Research [Amsterdam, Pays-Bas] (CNCR), Vrije Universiteit Amsterdam [Amsterdam] (VU), Department of Oncology [Candiolo, Italie], Candiolo Cancer Institute [Candiolo, Italie], Università degli studi di Torino (UNITO)-Università degli studi di Torino (UNITO), Research Institute for Frontier Medicine [Sapporo, Japon], Sapporo Medical University School of Medicine, Sapporo Medical University-Sapporo Medical University, Laboratory of Molecular Oncology and Angiogenesis [Louvain, Belgique], Vesalius Research Center [Louvain, Belgique], Physiopathologie du système nerveux central - Institut François Magendie, Université Bordeaux Segalen - Bordeaux 2-IFR8-Institut National de la Santé et de la Recherche Médicale (INSERM), The Saban Research Institute [Los Angeles, CA, États-Unis], Children’s Hospital Los Angeles [Los Angeles]-University of Southern California (USC), This research was supported by the Agence National pour la Recherche (ANR, France) grants ANR-07-NEURO-026-03 (to VP), ANR-09-BLAN-0267 (to VP), ANR-2010-JCJC-1404-01 (to PG), ANR 11 BSV1 02102 (to SGB and PC), and PERI-PULSE ANR 12 BSV1 0032 (to VP), the Fondation pour la Recherche Médicale (Equipe FRM 2005 & DEQ20130326524, France, to VP), the European INTERREG program TC2N (to VP and SGB), the Institut Fédératif de Recherche 114 (IFR114, France, electron microscopy core facility), the University of Lille 2, Lille, France (grant: Appel à Projets du Conseil Scientifique de l’Université Lille 2 to PG), the Compagnia di San Paolo-2008.1224 (Turin, Italy, to PG and LT), and the EU FP7 program Plastisice (to JV). CC was supported by a doctoral fellowship from the Inserm and the Région Nord Pas de Calais., ANR-09-BLAN-0267,gliodiabesity(2009), ANR-12-BSV1-0032,Peri-pulse,Péricytes et couplage stimulation-sécrétion in vivo(2012), Harris, William A, Bodescot, Myriam, Blanc - - gliodiabesity2009 - ANR-09-BLAN-0267 - Blanc - VALID, BLANC - Péricytes et couplage stimulation-sécrétion in vivo - - Peri-pulse2012 - ANR-12-BSV1-0032 - BLANC - VALID, Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 (JPArc), Université Lille Nord de France (COMUE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Université Lille Nord de France (COMUE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Université de Lille-UNICANCER-Université de Lille-UNICANCER-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Università degli studi di Torino = University of Turin (UNITO)-Università degli studi di Torino = University of Turin (UNITO), University of Southern California (USC)-Children’s Hospital Los Angeles [Los Angeles], Giacobini, Paolo, Parkash, Jyoti, Campagne, Céline, Messina, Andrea, Casoni, Filippo, Vanacker, Charlotte, Langlet, Fanny, Hobo, Barbara, Cagnoni, Gabriella, Gallet, Sarah, Hanchate, Naresh Kumar, Mazur, Danièle, Taniguchi, Masahiko, Mazzone, Massimiliano, Verhaagen, Joost, Ciofi, Philippe, Bouret, Sébastien G, Tamagnone, Luca, and Prevot, Vincent
Subjects: Anatomy and Physiology, Neuropilin-1 (Nrp1), Signaling pathways, Gene Expression, Gonadotropin-releasing hormone, Ligands, AXON GUIDANCE, Gonadotropin-Releasing Hormone, Rats, Sprague-Dawley, Mice, Endocrinology, Integrative Physiology, SECRETED SEMAPHORINS, Neuropilin 1, Sema3A, gonadotropin-releasing hormone (GnRH), rat estrous cycle, Biology (General), hypotalamic neurons, median eminence, synaptic transmission, HORMONE-RELEASE, ARCUATE NUCLEUS, Endothelial Cell, General Neuroscience, Brain, 3. Good health, Medicine, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Settore BIO/17 - ISTOLOGIA, Signal transduction, General Agricultural and Biological Sciences, Research Article, Signal Transduction, medicine.medical_specialty, endocrine system, QH301-705.5, Neuropeptide, Ligand, Endocrine System, Estrous Cycle, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Biology, Axon, Neurological System, General Biochemistry, Genetics and Molecular Biology, Semaphorin, Internal medicine, medicine, Animals, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], [SDV.BC] Life Sciences [q-bio]/Cellular Biology, [SDV.BDLR] Life Sciences [q-bio]/Reproductive Biology, General Immunology and Microbiology, Animal, Reproductive System, Endothelial Cells, SEMA3A, Semaphorin-3A, [SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology, Neuroendocrinology, Luteinizing Hormone, Axons, Neuropilin-1, Rats, Mice, Inbred C57BL, Fertility, Synaptic plasticity, Rat, Hormone
Abstract: Endothelial-cell–derived Sema3A promotes axonal outgrowth and plasticity and thereby regulates neurohormone release in the adult rodent brain in response to the ovarian cycle., Neuropilin-1 (Nrp1) guides the development of the nervous and vascular systems, but its role in the mature brain remains to be explored. Here we report that the expression of the 65 kDa isoform of Sema3A, the ligand of Nrp1, by adult vascular endothelial cells, is regulated during the ovarian cycle and promotes axonal sprouting in hypothalamic neurons secreting gonadotropin-releasing hormone (GnRH), the neuropeptide controlling reproduction. Both the inhibition of Sema3A/Nrp1 signaling and the conditional deletion of Nrp1 in GnRH neurons counteract Sema3A-induced axonal sprouting. Furthermore, the localized intracerebral infusion of Nrp1- or Sema3A-neutralizing antibodies in vivo disrupts the ovarian cycle. Finally, the selective neutralization of endothelial-cell Sema3A signaling in adult Sema3a loxP/loxP mice by the intravenous injection of the recombinant TAT-Cre protein alters the amplitude of the preovulatory luteinizing hormone surge, likely by perturbing GnRH release into the hypothalamo-hypophyseal portal system. Our results identify a previously unknown function for 65 kDa Sema3A-Nrp1 signaling in the induction of axonal growth, and raise the possibility that endothelial cells actively participate in synaptic plasticity in specific functional domains of the adult central nervous system, thus controlling key physiological functions such as reproduction., Author Summary In the developing embryo, endothelial cells release chemotropic signals such as Semaphorin 3A (Sema3A) that, upon activation of its receptor Neuropilin-1 (Nrp1), regulate neuronal migration and axon guidance. However, whether endothelial cells in the adult brain retain the ability to secrete molecules that influence neuronal function is unknown. Here we show in the adult brain of rodents that vascular endothelial cells release Sema3A and that the amount released is regulated by the ovulatory cycle. Sema3A, in turn, promotes the outgrowth of axons of hypothalamic neurons that express Neuropilin-1 towards the endothelial wall of portal blood vessels. These neurons release there the neuropeptide that controls reproduction: gonadotropin-releasing hormone (GnRH). Notably, this endothelial-cell-mediated sprouting of GnRH axons regulates neuropeptide release at a key stage of the estrous cycle, the proestrus, when the surge of GnRH triggers ovulation. Thus, by promoting GnRH axonal growth in the adult brain, Sema3A/Neuropilin-1 plays a pivotal role in orchestrating the central control of reproduction. Our results suggest a model in which vascular endothelial cells are dynamic signaling components that relay peripheral information to the brain to control key physiological functions, including species survival.
Published: 2014

45. Assessing heavy metal exposure in Renaissance Europe using synchrotron microbeam techniques

Author: Ezio Ferroglio, Timothy G. Bromage, Raffaella Bianucci, Racquel Z. LeGeros, Gino Fornaciari, Antonio Lanzirotti, Valentina Giuffra, Otto Appenzeller, Center for Advanced Radiation Sources [University of Chicago] (CARS), University of Chicago, Anthropologie bio-culturelle, Droit, Ethique et Santé (ADES), Aix Marseille Université (AMU)-EFS ALPES MEDITERRANEE-Centre National de la Recherche Scientifique (CNRS), Department of Public Health and Pediatric Sciences, Université de Turin, Università degli studi di Torino (UNITO)-Università degli studi di Torino (UNITO), Department of Biomaterials and Biomimetics, New York University College of Dentistry, NYU System (NYU)-NYU System (NYU), Division of paleopathology, History of Medicine and Bioethics, University of Pisa - Università di Pisa, Dipartimento Produzioni Animali Epidemiologia ed Ecologia, Università degli studi di Torino (UNITO), New Mexico Health Enhancement and Marathon Clinics Research Foundation, Marathon Clinics Research Foundation, Università degli studi di Torino = University of Turin (UNITO)-Università degli studi di Torino = University of Turin (UNITO), and Università degli studi di Torino = University of Turin (UNITO)
Subjects: History, Archeology, Heavy metals, Neapolitan nobles, Renaissance, Synchrotron microprobe, X-ray absorption spectroscopy, X-ray fluorescence, Zoonotic visceral leishmaniasis, [SHS.ANTHRO-BIO]Humanities and Social Sciences/Biological anthropology, Mineralogy, chemistry.chemical_element, 01 natural sciences, law.invention, Metal, 03 medical and health sciences, law, 030304 developmental biology, 0303 health sciences, 010401 analytical chemistry, The Renaissance, Synchrotron, 0104 chemical sciences, Mercury (element), chemistry, visual_art, visual_art.visual_art_medium, Environmental science
Abstract: A number of archaeological studies have used chemical analysis of preserved, human biological tissues to assess the potential exposure of historic figures and ancient populations to heavy metals. Accurately assessing historic levels of heavy-metal body burden for these individuals based on analysis of remnant soft-tissue, hair and bone collected from preserved human remains is often complicated by the potential for post-mortem chemical modifications and contamination of the body and burial site. This study employs high-resolution, synchrotron-based elemental X-ray fluorescence mapping, tomography and absorption spectroscopy of human remains collected in an archaeological context in an effort to discriminate between heavy metals such as mercury and lead that may have been incorporated through either endogenous or exogenous processes. These methods were used to analyze bone and hair samples from Ferrante II of Aragon, King of Naples (1469–1496) and Isabella of Aragon, Duchess of Milan (1470–1524). These individuals are likely to have been exposed to generally similar levels of heavy metals in their lifetime, would have been embalmed using similar methods and the post-mortem exposure to contaminants is likely to have been similar. Although the remains from both Ferrante II of Aragon and Isabella of Aragon contain high amounts of mercury and lead, the high-resolution and –sensitivity synchrotron microprobe techniques employed in this study provide insight in to the likelihood these metals were incorporated pre-mortem rather than as ante-mortem contaminants. Although synchrotron X-ray fluorescence mapping and tomography are generally consistent with measured mercury from Isabella hair samples being endogenous in nature, the high levels of mercury seen in Ferrante II's remains are most likely related to post-mortem embalming of the corpse. However, application of microfocused X-ray fluorescence compositional mapping and lead L2 edge X-ray absorption spectroscopy to bone samples collected from Ferrante II show that the measured lead is likely endogenous and the result of in-life exposure to this heavy metal.
Published: 2014

46. Management of anaphylaxis due to COVID-19 vaccines in the elderly

Author: Paulo Augusto Moreira Camargos, Radolslaw Gawlik, Mirko Petrovic, Gunter J. Sturm, Kristof Nekam, Sergio Bonini, Zhanat Ispayeva, Marilyn Urrutia Pereira, Jean Bousquet, Antti Lauerma, Menachem Rottem, Arzu Yorgancioglu, Hubert Blain, Antonio Cherubini, Mário Morais-Almeida, Nathalie Salles, Charlotte G. Mortz, Sylwia Smolinska, Davor Plavec, A. Bedbrook, Torsten Zuberbier, Helga Kraxner, M. Beatrice Bilò, Sinthia Bosnic-Anticevich, Gaëtan Gavazzi, Finbarr C. Martin, Alvaro A. Cruz, K. S. Bennoor, Isabella Annesi-Maesano, Mohamed H. Shamji, Karin Hoffmann-Sommergruber, Marina Atanaskovic-Markovic, Carsten Bindslev-Jensen, Lan Tt Le, Isabel Skypala, Ana Todo-Bom, Vincenzo Patella, Lorenzo Cecchi, Charlotte Suppli Ulrik, Oscar Palomares, Joaquin Sastre, Hans Jürgen Hoffmann, Knut Brockow, Eva Untersmayr, Martin Hrubisko, Bernadette Eberlein, Aziz Sheikh, Milan Sova, Osman M. Yusuf, Violeta Kvedariene, G. Walter Canonica, Dana Wallace, Ioana Agache, Milena Sokolowska, Jos M. G. A. Schols, Susan Waserman, Stéphanie Miot, Carla Irani, Regina E Roller-Winsberger, Michael Levin, Yves Rolland, Emma Montella, Bilun Gemicioglu, Bolesław Samoliński, Stefano Del Giacco, Madda lenaIllario, Yehia El-Gamal, Olga Lourenço, Jean-Christoph Roger J-P Caubet, Luisa Brussino, Marysia Recto, De Yun Wang, Igor Kaidashev, Renaud Louis, Antonino Romano, Mario E. Zernotti, Jacques Reynes, Pedro Carreiro-Martins, Alexandra F. Santos, Marek Niedoszytko, M. Gotua, Musa Khaitov, Thomas B. Casale, Andrea Matucci, Bernardo Sousa-Pinto, Rafael Stelmach, Dejan Dokic, Joana Vitte, Motohiro Ebisawa, Maria Teresa Ventura, Joaquim Mullol, Tomas Chivato, Petr Panzner, Oliver Pfaar, Sanna Toppila-Salmi, Ioanna Tsiligianni, Wytske Fokkens, Alessandra Vultaggio, H. Neffen, Juan Carlos Ivancevich, Ya-dong Gao, Anna Sediva, Maja Hofmann, Ana Maria Carriazo, João Fonseca, Marek Jutel, A. Benetos, Nhân Pham-Thi, Mona Al-Ahmad, Arunas Valiulis, Mihaela Zidarn, Elizabeth Angier, Yoshitaka Okamoto, Montserrat Fernandez-Rivas, Cezmi A. Akdis, Philip W. Rouadi, Olivier Guérin, John Farrell, Mikaela Odemyr, George Christoff, Vera Mahler, Claus Bachert, Edward F. Knol, Wienczyslawa Czarlewski, Robyn E O'Hehir, Victoria Cardona, Ludger Klimek, Tari Haahtela, Vincent Le Moing, Branislava Milenkovic, Carmen Rondon, Kaja Julge, Jolanta Walusiak-Skorupa, Nikolaos G. Papadopoulos, Aslı Gelincik, Markus Ollert, Piotr Kuna, Leyla Namazova-Baranova, Margitta Worm, Annick Barbaud, Elena Camelia Berghea, Todor A. Popov, Derek K. Chu, María José Torres, Faradiba Sarquis Serpa, Nicola Scichilone, Amir Hamzah Abdul Latiff, Frederico S. Regateiro, Gianni Passalacqua, Humboldt-Universität zu Berlin, Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Institut Hospitalier Universitaire Méditerranée Infection (IHU Marseille), Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Center for Rhinology and Allergology Wiesbaden, University Hospital Mannheim, Humboldt University Of Berlin, Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Transylvania University, Wrocław Medical University, Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro (UNIBA), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], University of Cagliari, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Università Politecnica delle Marche [Ancona] (UNIVPM), Medical Consulting Czarlewski, Universiti Putra Malaysia, University of Southampton, Institut Desbrest de santé publique (IDESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), University of Belgrade [Belgrade], Ghent University Hospital, CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Dhaka Shishu Hospital [Bangladesh], University of Medicine and Pharmacy 'Carol Davila' Bucharest (UMPCD), Odense University Hospital (OUH), Italian National Research Council, National Research Council [Italy] (CNR), The University of Sydney, Technische Universität München = Technical University of Munich (TUM), Università degli studi di Torino = University of Turin (UNITO), Universidade Federal de Minas Gerais = Federal University of Minas Gerais [Belo Horizonte, Brazil] (UFMG), IRCCS Research Hospital, Milan, Vall d'Hebron University Hospital [Barcelona], Centro Hospitalar de Lisboa Central E.P.E, University of South Florida [Tampa] (USF), Geneva University Hospital (HUG), Azienda Usl Toscana centro [Firenze], Софийски университет = Sofia University, McMaster University [Hamilton, Ontario], State University of Bahia, Institute of Public Health of Republic of North Macedonia [Skopje], Ain Shams University (ASU), Sagamihara National Hospital [Kanagawa, Japan], Instituto de Investigación Sanitaria del Hospital Clínico San Carlos [Madrid, Spain] (IdISSC), Amsterdam UMC - Amsterdam University Medical Center, Universidade do Porto = University of Porto, Wuhan University [China], CHU Grenoble, Silesian University of Medicine, Istanbul Faculty of Medicine, Cerrahpasa Faculty of Medicine, Istanbul University, Centre Hospitalier Universitaire de Nice (CHU Nice), Helsinki University Hospital [Helsinki, Finlande], Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Medizinische Universität Wien = Medical University of Vienna, Aarhus University [Aarhus], Oncology Institute of St Elisabeth, University of Naples Federico II = Università degli studi di Napoli Federico II, St Joseph University, Hôtel-Dieu de France (HDF), Université Saint-Joseph de Beyrouth (USJ), Kazakh National Medical University, Servicio de Alergia e ImmunologiaBuenos Aires (Clinica Santa Isabel), Tartu University Institute of Clinical Medicine, Ukrainina Medical Stomatological Academy [Poltava, Ukraine], Federal Medicobiological Agency [Moscow, Russian Federation], University Medical Center [Utrecht], Semmelweis University [Budapest], Medical University of Łódź (MUL), Vilnius University [Vilnius], University of Medicine and Pharmacy (VIETNAM), University of Cape Town, CHU Sart Tilman, Université de Liège, University of Beira Interior [Portugal] (UBI), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), uBibliorum, Ear, Nose and Throat, AII - Inflammatory diseases, CHU Montpellier, Wroclaw Medical University [Wrocław, Pologne], University of Bari Aldo Moro (UNIBA), Service de Médecine Interne = Hôpital de jour de médecine [CHU Tenon], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Sagamihara National Hospital, Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques er émergentes (TransVIHMI), Institut de Recherche pour le Développement (IRD)-Université de Yaoundé I-Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), CHU Toulouse [Toulouse], RS: CAPHRI - R1 - Ageing and Long-Term Care, Health Services Research, Bousquet J., Agache I., Blain H., Jutel M., Ventura M.T., Worm M., Del Giacco S., Benetos A., Bilo B.M., Czarlewski W., Abdul Latiff A.H., Al-Ahmad M., Angier E., Annesi-Maesano I., Atanaskovic-Markovic M., Bachert C., Barbaud A., Bedbrook A., Bennoor K.S., Berghea E.C., Bindslev-Jensen C., Bonini S., Bosnic-Anticevich S., Brockow K., Brussino L., Camargos P., Canonica G.W., Cardona V., Carreiro-Martins P., Carriazo A., Casale T., Caubet J.-C., Cecchi L., Cherubini A., Christoff G., Chu D.K., Cruz A.A., Dokic D., El-Gamal Y., Ebisawa M., Eberlein B., Farrell J., Fernandez-Rivas M., Fokkens W.J., Fonseca J.A., Gao Y., Gavazzi G., Gawlik R., Gelincik A., Gemicioglu B., Gotua M., Guerin O., Haahtela T., Hoffmann-Sommergruber K., Hoffmann H.J., Hofmann M., Hrubisko M., Illario M., Irani C., Ispayeva Z., Ivancevich J.C., Julge K., Kaidashev I., Khaitov M., Knol E., Kraxner H., Kuna P., Kvedariene V., Lauerma A., Le L.T.T., Le Moing V., Levin M., Louis R., Lourenco O., Mahler V., Martin F.C., Matucci A., Milenkovic B., Miot S., Montella E., Morais-Almeida M., Mortz C.G., Mullol J., Namazova-Baranova L., Neffen H., Nekam K., Niedoszytko M., Odemyr M., O'Hehir R.E., Okamoto Y., Ollert M., Palomares O., Papadopoulos N.G., Panzner P., Passalacqua G., Patella V., Petrovic M., Pfaar O., Pham-Thi N., Plavec D., Popov T.A., Recto M.T., Regateiro F.S., Reynes J., Roller-Winsberger R.E., Rolland Y., Romano A., Rondon C., Rottem M., Rouadi P.W., Salles N., Samolinski B., Santos A.F., S Sarquis F., Sastre J., M. G. A. Schols J., Scichilone N., Sediva A., Shamji M.H., Sheikh A., Skypala I., Smolinska S., Sokolowska M., Sousa-Pinto B., Sova M., Stelmach R., Sturm G., Suppli Ulrik C., Todo-Bom A.M., Toppila-Salmi S., Tsiligianni I., Torres M., Untersmayr E., Urrutia Pereira M., Valiulis A., Vitte J., Vultaggio A., Wallace D., Walusiak-Skorupa J., Wang D.-Y., Waserman S., Yorgancioglu A., Yusuf O.M., Zernotti M., Zidarn M., Chivato T., Akdis C.A., Zuberbier T., Klimek L., HUS Inflammation Center, University of Helsinki, and Department of Dermatology, Allergology and Venereology
Subjects: Male, Allergy, Pediatrics, Eaaci Position Paper, COVID-19 vaccines, older (adults, GUIDELINES, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Medicine and Health Sciences, Immunology and Allergy, Medicine, 030212 general & internal medicine, ComputingMilieux_MISCELLANEOUS, Geriatrics, MESH: Aged, RISK, Vaccines, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, people), EPINEPHRINE, Epinephrine, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, COVID -19 vaccines, Anaphylaxis, medicine.drug, older (adults/people), medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), MESH: Covid-19, MESH: Epinephrine, Immunology, adrenaline, anaphylaxis, Aged, COVID-19 Vaccines, Humans, SARS-CoV-2, COVID-19, Settore MED/10 - Malattie Dell'Apparato Respiratorio, 03 medical and health sciences, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Diabetes mellitus, Anaphylaxis/etiology, MESH: SARS-CoV-2, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, COVID‐19 vaccines, Older - Adults/people, Asthma, MESH: Humans, business.industry, adrenaline, anaphylaxis, COVID-19 vaccines, older (adults/people), medicine.disease, Obesity, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, MESH: Male, MESH: Anaphylaxis, Older, 3121 General medicine, internal medicine and other clinical medicine, business, MESH: Covid-19 vaccines, 030215 immunology
Abstract: Submitted by (omml@ubi.pt) on 2021-07-05T10:47:24Z No. of bitstreams: 1 2021_Bousquet J_A_COVID anaphylaxis.pdf: 12561118 bytes, checksum: 2f801ee76ad2cb3cbdaa02ffabea8e09 (MD5) Approved for entry into archive by Pessoa (pfep@ubi.pt) on 2021-07-05T10:49:11Z (GMT) No. of bitstreams: 1 2021_Bousquet J_A_COVID anaphylaxis.pdf: 12561118 bytes, checksum: 2f801ee76ad2cb3cbdaa02ffabea8e09 (MD5) Rejected by Pessoa (pfep@ubi.pt), reason: Rever os nomes dos autores. Depois da correção é só voltar a submeter. on 2021-07-05T10:54:19Z (GMT) Submitted by (omml@ubi.pt) on 2021-07-05T11:52:24Z No. of bitstreams: 1 2021_Bousquet J_A_COVID anaphylaxis.pdf: 12561118 bytes, checksum: 2f801ee76ad2cb3cbdaa02ffabea8e09 (MD5) Approved for entry into archive by Pessoa (pfep@ubi.pt) on 2021-07-05T13:34:51Z (GMT) No. of bitstreams: 1 2021_Bousquet J_A_COVID anaphylaxis.pdf: 12561118 bytes, checksum: 2f801ee76ad2cb3cbdaa02ffabea8e09 (MD5) Approved for entry into archive by Pessoa (pfep@ubi.pt) on 2021-07-05T13:35:49Z (GMT) No. of bitstreams: 1 2021_Bousquet J_A_COVID anaphylaxis.pdf: 12561118 bytes, checksum: 2f801ee76ad2cb3cbdaa02ffabea8e09 (MD5) Made available in DSpace on 2021-07-05T13:35:49Z (GMT). No. of bitstreams: 1 2021_Bousquet J_A_COVID anaphylaxis.pdf: 12561118 bytes, checksum: 2f801ee76ad2cb3cbdaa02ffabea8e09 (MD5) Previous issue date: 2021-04-02 info:eu-repo/semantics/publishedVersion
Published: 2021

47. Benefit of Extended Dual Antiplatelet Therapy Duration in Acute Coronary Syndrome Patients Treated with Drug Eluting Stents for Coronary Bifurcation Lesions (from the BIFURCAT Registry)

Author: Young Bin Song, Jeehoon Kang, Carlo Di Mario, Javier Escaned, Imad Sheiban, Han-Mo Yang, Saverio Muscoli, Seung Ho Hur, Davide Capodanno, Bernardo Cortese, Hyo-Soo Kim, Soon-Jun Hong, Guglielmo Gallone, Joon-Hyung Doh, Federico Conrotto, Daniela Trabattoni, Radosław Parma, Gérard Helft, Chang-Wook Nam, Ovidio De Filippo, Leonardo De Luca, Hyeon-Cheol Gwon, Grzegorz Smolka, Antonio Montefusco, Giuseppe Patti, Kyung-Woo Park, Fabrizio D'Ascenzo, Seung Hwan Han, Woo Jung Chun, Jung-Kyu Han, Iacopo Colonnelli, Bon-Kwon Koo, Gaetano M. De Ferrari, Enrico Cerrato, Yoichi Imori, Andrea Saglietto, Ki Hong Choi, Veronica Dusi, Alessandra Truffa Giachet, Francesco Bruno, Mario Iannaccone, Università degli studi di Torino = University of Turin (UNITO), Seoul National University Hospital, University Hospital 'Maggiore della Carità' [Novara, Italy], Medical University of Silesia (SUM), Ospedale San Camillo-Forlanini, Samsung Medical Center Sungkyunkwan University School of Medicine, Institute Division of Hematology/Oncology, Ospedale San Giovanni Bosco [Turin, Italy] (OSGB), Keimyung University, Ospedale San Luigi Gonzaga, Gachon University Gil Medical Center [Incheon, Republic of Korea], Careggi University Hospital [Florence, Italie], Instituto de Investigación Sanitaria del Hospital Clínico San Carlos [Madrid, Spain] (IdISSC), Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] (UCM), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] (IHU ICAN), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Inje University, Ospedale di Asti [Asti, Italy] (OA), Korea University Anam Hospital [Seoul], Università degli Studi di Roma Tor Vergata [Roma], AOU Policlinico Vittorio-Emanuele [Catania, Italia], IRCCS Istituto Nazionale dei Tumori [Milano], Nippon Medical School [Tokyo, Japon], Università degli Studi di Pavia = University of Pavia (UNIPV), ASST Fatebenefratelli-Sacco [Milan, Italy], Clinica Pederzoli [Peschiera del Garda, Italy] (CP), and Lesnik, Philippe
Subjects: Male, Acute coronary syndrome, medicine.medical_specialty, animal structures, [SDV]Life Sciences [q-bio], medicine.medical_treatment, Revascularization, Drug Administration Schedule, Percutaneous Coronary Intervention, Internal medicine, Clinical endpoint, Humans, Medicine, Registries, cardiovascular diseases, Myocardial infarction, Acute Coronary Syndrome, Aged, business.industry, Dual Anti-Platelet Therapy, Percutaneous coronary intervention, Drug-Eluting Stents, Middle Aged, medicine.disease, [SDV] Life Sciences [q-bio], Treatment Outcome, Cohort, Conventional PCI, Cardiology, Female, Cardiology and Cardiovascular Medicine, business, Platelet Aggregation Inhibitors, Mace, Follow-Up Studies
Abstract: Optimal dual antiplatelet therapy (DAPT) duration for patients undergoing percutaneous coronary intervention (PCI) for coronary bifurcations is an unmet issue. The BIFURCAT registry was obtained by merging two registries on coronary bifurcations. Three groups were compared in a two-by-two fashion: short-term DAPT (≤ 6 months), intermediate-term DAPT (6-12 months) and extended DAPT (>12 months). Major adverse cardiac events (MACE) (a composite of all-cause death, myocardial infarction (MI), target-lesion revascularization and stent thrombosis) were the primary endpoint. Single components of MACE were the secondary endpoints. Events were appraised according to the clinical presentation: chronic coronary syndrome (CCS) versus acute coronary syndrome (ACS). 5537 patients (3231 ACS, 2306 CCS) were included. After a median follow-up of 2.1 years (IQR 0.9-2.2), extended DAPT was associated with a lower incidence of MACE compared with intermediate-term DAPT (2.8% versus 3.4%, adjusted HR 0.23 [0.1-0.54], p
Published: 2021

48. Early-life respiratory tract infections and the risk of school-age lower lung function and asthma

Author: van Meel, Evelien R, Mensink-Bout, Sara M, den Dekker, Herman T, Ahluwalia, Tarunveer S, Annesi-Maesano, Isabella, Arshad, Syed Hasan, Baïz, Nour, Barros, Henrique, von Berg, Andrea, Bisgaard, Hans, Bønnelykke, Klaus, Carlsson, Christian J, Casas, Maribel, Chatzi, Leda, Chevrier, Cecile, Dalmeijer, Geertje, Dezateux, Carol, Duchen, Karel, Eggesbø, Merete, van der Ent, Cornelis, Fantini, Maria, Flexeder, Claudia, Frey, Urs, Forastiere, Fransesco, Gehring, Ulrike, Gori, Davide, Granell, Raquel, Griffiths, Lucy J, Inskip, Hazel, Jerzynska, Joanna, Karvonen, Anne M, Keil, Thomas, Kelleher, Cecily, Kogevinas, Manolis, Koppen, Gudrun, Kuehni, Claudia E, Lambrechts, Nathalie, Lau, Susanne, Lehmann, Irina, Ludvigsson, Johnny, Magnus, Maria Christine, Mélen, Erik, Mehegan, John, Mommers, Monique, Nybo Andersen, Anne-Marie, Nystad, Wenche, Pedersen, Eva S L, Pekkanen, Juha, Peltola, Ville, Pike, Katharine C, Pinot de Moira, Angela, Pizzi, Costanza, Polanska, Kinga, Popovic, Maja, Porta, Daniela, Roberts, Graham, Santos, Ana Cristina, Schultz, Erica S, Standl, Marie, Sunyer, Jordi, Thijs, Carel, Toivonen, Laura, Uphoff, Eleonora, Usemann, Jakob, Vafeidi, Marina, Wright, John, de Jongste, Johan C, Jaddoe, Vincent W V, Duijts, Liesbeth, IRAS OH Epidemiology Chemical Agents, Salvy-Córdoba, Nathalie, The Generation R Study Group, Erasmus University Medical Center [Rotterdam] (Erasmus MC), Department of Epidemiology, Erasmus University Medical Center, Rotterdam, Herlev and Gentofte Hospital, Institut Desbrest de santé publique (IDESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Epidemiology of Allergic and Respiratory Diseases Department [iPlesp] (EPAR), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), St Mary's Hospital [London], University Hospital Southampton NHS Foundation Trust, Departamento de Ciências da Saúde Pública e Forenses e Educação Médica [Porto, Portugal], Faculdade de Medicina da Universidade do Porto (FMUP), Universidade do Porto = University of Porto-Universidade do Porto = University of Porto, ISPUP-EPIUnit, University of Porto Medical School and Institute of Public Health, Marien-Hospital Wesel gGmbH, Instituto de Salud Global - Institute For Global Health [Barcelona] (ISGlobal), Universitat Pompeu Fabra [Barcelona] (UPF), CIBER de Epidemiología y Salud Pública (CIBERESP), University of Southern California (USC), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Julius Center for Health Sciences and Primary Care, University Medical Center [Utrecht], Barts & The London School of Medicine and Dentistry, Linköping university hospital, Norwegian Institute of Public Health [Oslo] (NIPH), Alma Mater Studiorum University of Bologna (UNIBO), Helmholtz Zentrum München = German Research Center for Environmental Health, University Children’s Hospital Basel = Hôpital pédiatrique universitaire des deux Bâle [Bâle, Suisse] (UKBB), Lazio Regional Health Service [Rome], Institute for Risk Assessment Sciences [Utrecht, The Netherlands] (IRAS), Utrecht University [Utrecht], MRC Integrative Epidemiology Unit [Bristol, Royaume-Uni] (MRC IEU), University of Bristol [Bristol], Swansea University Medical School [Swansea, Royaume-Uni], Swansea University, University of Southampton, Nofer Institute of Occupational Medicine (NIOM), Finnish Institute for Health and Welfare [Helsinki, Finland] (FIHW), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], University of Würzburg = Universität Würzburg, Bavarian Health and Food Safety Authority, School of Public Health, Physiotherapy and Sports Science [Dublin, Irlande], University College Dublin [Dublin] (UCD), National School of Public Health [Athens], IMIM-Hospital del Mar, Generalitat de Catalunya, Flemish Institute for Technological Research (VITO), Institute of Social and Preventive Medicine [Bern] (ISPM), Universität Bern [Bern] (UNIBE), Bern University Hospital [Berne] (Inselspital), Helmholtz Zentrum für Umweltforschung = Helmholtz Centre for Environmental Research (UFZ), Sach's Children's Hospital [Stockholm], Maastricht University Medical Centre (MUMC), Maastricht University [Maastricht], University of Copenhagen = Københavns Universitet (UCPH), TKK Helsinki University of Technology (TKK), Turku University Hospital (TYKS), Bristol Royal Hospital for Children, Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Department of Medical Sciences [Turin, Italy] (DMS), Università degli studi di Torino = University of Turin (UNITO), The David Hide Asthma and Allergy Research Centre, St Mary's Hospital-University Hospital Southampton NHS Foundation Trust, Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, German Research Center for Environmental Health - Helmholtz Center München (GmbH), Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK, University of Crete [Heraklion] (UOC), Epidemiologie, RS: CAPHRI - R5 - Optimising Patient Care, Pediatrics, Epidemiology, IRAS OH Epidemiology Chemical Agents, and Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK (BIHR)
Subjects: Pulmonary and Respiratory Medicine, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, Vital Capacity, Infant, 610 Medicine & health, ALSPAC, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, Asthma, [SDV.MHEP.PED] Life Sciences [q-bio]/Human health and pathology/Pediatrics, 360 Social problems & social services, Child, Preschool, Forced Expiratory Volume, [SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, Humans, Prospective Studies, Child, Preschool, Lung, Respiratory Tract Infections
Abstract: Background: Early-life respiratory tract infections might affect chronic obstructive respiratory diseases, but conclusive studies from general populations are lacking. Our objective was to examine if children with early-life respiratory tract infections had increased risks of lower lung function and asthma at school age. Methods: We used individual participant data of 150 090 children primarily from the EU Child Cohort Network to examine the associations of upper and lower respiratory tract infections from age 6 months to 5 years with forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), FEV1/FVC, forced expiratory flow at 75% of FVC (FEF75%) and asthma at a median (range) age of 7 (4-15) years. Results: Children with early-life lower, not upper, respiratory tract infections had a lower school-age FEV1, FEV1/FVC and FEF75% (z-score range: -0.09 (95% CI -0.14- -0.04) to -0.30 (95% CI -0.36- -0.24)). Children with early-life lower respiratory tract infections had a higher increased risk of school-age asthma than those with upper respiratory tract infections (OR range: 2.10 (95% CI 1.98-2.22) to 6.30 (95% CI 5.64-7.04) and 1.25 (95% CI 1.18-1.32) to 1.55 (95% CI 1.47-1.65), respectively). Adjustment for preceding respiratory tract infections slightly decreased the strength of the effects. Observed associations were similar for those with and without early-life wheezing as a proxy for early-life asthma. Conclusions: Our findings suggest that early-life respiratory tract infections affect development of chronic obstructive respiratory diseases in later life, with the strongest effects for lower respiratory tract infections. A comprehensive list of grant funding is available on the ALSPAC website (www.bristol.ac.uk/alspac/external/documents/grant-acknowledgements.pdf). BAMSE: BAMSE was funded by the Swedish Research Council, the Swedish Heart Lung Foundation, ALF Region Stockholm and SFO Epidemiology Karolinska Institutet. E. Mélen is supported by a European Research Council grant (TRIBAL, 757919). BiB (Born in Bradford): BiB is only possible because of the enthusiasm and commitment of the children and parents in BiB. We are grateful to all the participants, practitioners and researchers who have made BiB happen. The BiB study presents independent research commissioned by the National Institute for Health Research Collaboration for Applied Health Research and Care (NIHR CLAHRC) and the Programme Grants for Applied Research funding scheme (RP-PG-0407-10044). Core support for BiB is also provided by the Wellcome Trust (WT101597MA). BILD: This study was funded by the Swiss National Science Foundation (320030_163311). CoNER: Funds were obtained from the special programme (Programmi speciali – Art.12 bis, comma 6 D.lgs.229/99 Sanitaria e della Vigilanza sugli Enti) funded by the Italian Ministry of Health. Approval for the study was obtained from the Ethics Committee of the S. Orsola-Malpighi Teaching Hospital in April 2004 (52/2004/U/Tess). COPSAC 2000 and COPSAC 2010: All funding received by COPSAC is listed on www.copsac.com. The Lundbeck Foundation (R16-A1694), Ministry of Health (903516), Danish Council for Strategic Research (0603-00280B) and Capital Region Research Foundation have provided core support to the COPSAC research centre. We express our deepest gratitude to the children and families of the COPSAC 2000 and COPSAC 2010 cohort studies for all their support and commitment. We acknowledge and appreciate the unique efforts of the COPSAC research team. DNBC (Danish National Birth Cohort): The authors would like to thank the participants, the first Principal Investigator of DNBC, Jørn Olsen, the scientific managerial team and DNBC secretariat for being, establishing, developing and consolidating the DNBC. The DNBC was established with a significant grant from the Danish National Research Foundation. Additional support was obtained from the Danish Regional Committees, Pharmacy Foundation, Egmont Foundation, March of Dimes Birth Defects Foundation, Health Foundation and other minor grants. The DNBC Biobank has been supported by the Novo Nordisk Foundation and Lundbeck Foundation. Follow-up of mothers and children has been supported by the Danish Medical Research Council (SSVF 0646, 271-08-0839/06-066023, O602-01042B, 0602-02738B), Lundbeck Foundation (195/04, R100-A9193), Innovation Fund Denmark 0603-00294B (09-067124), Nordea Foundation (02-2013-2014), Aarhus Ideas (AU R9-A959-13-S804), University of Copenhagen Strategic Grant (IFSV 2012) and Danish Council for Independent Research (DFF-4183-00594, DFF-4183-00152). A. Pinot de Moira is funded by a Lundbeck Foundation grant (R264-2017-3099). EDEN: We thank the EDEN mother–child cohort study group (I. Annesi-Maesano, J.Y. Bernard, J. Botton, M.A. Charles, P. Dargent-Molina, B. de Lauzon-Guillain, P. Ducimetière, M. de Agostini, B. Foliguet, A. Forhan, X. Fritel, A. Germa, V. Goua, R. Hankard, B. Heude, M. Kaminski, B. Larroque†, N. Lelong, J. Lepeule, G. Magnin, L. Marchand, C. Nabet, F. Pierre, R. Slama, M.J. Saurel-Cubizolles, M. Schweitzer and O. Thiebaugeorges). We thank all funding sources for the EDEN study (not allocated for the present study but for the cohort): Foundation for Medical Research (FRM), National Agency for Research (ANR), National Institute for Research in Public health (IRESP: TGIR cohorte santé 2008 programme), French Ministry of Health (DGS), French Ministry of Research, INSERM Bone and Joint Diseases National Research (PRO-A) and Human Nutrition National Research Programs, Paris-Sud University, Nestlé, French National Institute for Population Health Surveillance (InVS), French National Institute for Health Education (INPES), the European Union FP7 programmes (FP7/2007-2013, HELIX, ESCAPE, ENRIECO, MeDALL projects), Diabetes National Research Program (in collaboration with the French Association of Diabetic Patients (AFD)), French Agency for Environmental Health Safety (now ANSES), Mutuelle Générale de l'Education Nationale complementary health insurance (MGEN), French national agency for food security, and French speaking association for the study of diabetes and metabolism (ALFEDIAM). The funding source had no involvement in the conception of the present study. FLEHS: This study was conducted within the framework of the Flemish Centre of Expertise on Environment and Health, funded by the Dept of the Environment of the Flemish Government, Flemish Agency of Care and Health, and Flemish Dept of Economy, Science and Innovation. GASPII: The GASPII cohort was funded by the Italian Ministry of Health (2001), the research leading to these results has received funding from the European Community's Seventh Framework Program under grant agreement 261357 (MeDALL). Generation R: This study was funded by Erasmus MC Rotterdam, Erasmus University Rotterdam and the Netherlands Organisation for Health Research and Development. V.W.V. Jaddoe received a grant from the European Research Council (ERC-2014-CoG-648916). L. Duijts received funding from cofunded ERA-Net on Biomarkers for Nutrition and Health (ERA HDHL), Horizon 2020 (696295; 2017), the Netherlands Organisation for Health Research and Development (ZonMw; 529051014; 2017), Science Foundation Ireland (SFI/16/ERA-HDHL/3360), and European Union (ALPHABET project). The project received funding from the European Union's Horizon 2020 research and innovation programme (LIFECYCLE, 733206, 2016; EUCAN-Connect 824989; ATHLETE, 874583). The researchers are independent from the funders. The study sponsors had no role in the study design, data analysis, interpretation of data or writing of this report. Generation XXI: Generation XXI was supported by the European Regional Development Fund (ERDF) through the Operational Programme Competitiveness and Internationalization and national funding from the Foundation for Science and Technology (FCT), Portuguese Ministry of Science, Technology and Higher Education, and by the Unidade de Investigação em Epidemiologia – Instituto de Saúde Pública da Universidade do Porto (EPIUnit) (UIDB/04750/2020), Administração Regional de Saúde Norte (Regional Dept of Ministry of Health) and Fundação Calouste Gulbenkian. A.C. Santos is founded by FCT Investigator contracts IF/01060/2015. GINI: The GINIplus study was mainly supported for the first 3 years by the Federal Ministry for Education, Science, Research and Technology (interventional arm) and Helmholtz Zentrum München (former GSF) (observational arm). The 4- and 6-year follow-up examinations of the GINIplus study were covered from the respective budgets of the five study centres (Helmholtz Zentrum München (former GSF), Research Institute at Marien-Hospital, Wesel, LMU Munich, TU Munich and from 6 years onwards also from IUF – Leibniz Research Institute for Environmental Medicine at the University of Düsseldorf). HUMIS: We thank all mothers for participating in the HUMIS study. HUMIS was funded by a grant from the Norwegian Research Council (226402). The HUMIS study was approved by the Norwegian Data Inspectorate (2002/1398) and by the Regional Ethics Committee for Medical Research in Norway (S-02122), and the specific use in the current study was approved by the Ethics Committee as well (2010/1259/REK sør-øst). INMA: Gipuzkoa: This study was funded by grants from Instituto de Salud Carlos III (FIS-PI09/00090, FIS-PI18/01142 including FEDER funds), CIBERESP, Dept of Health of the Basque Government (2013111089) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu, Legazpi, Azkoitia y Azpeitia and Beasain). Menorca: This study was funded by grants from Instituto de Salud Carlos III (Red INMA G03/176; CB06/02/0041; 97/0588; 00/0021-2, PI061756; PS0901958, PI14/00677 including FEDER funds), CIBERESP, Beca de la IV convocatoria de Ayudas a la Investigación en Enfemerdades Neurodegeneratives de La Caixa, and EC contract QLK4-CT-200-00263. Sabadell: This study was funded by grants from Instituto de Salud Carlos III (Red INMA G03/176; CB06/02/0041; PI041436; PI081151 including FEDER funds), Generalitat de Catalunya-CIRIT 1999SGR 00241 and Fundació La marató de TV3 (090430). ISGlobal is a member of the CERCA Programme, Generalitat de Catalunya. M. Casas holds a Miguel Servet fellowship (CP16/00128) funded by Instituto de Salud Carlos III and cofunded by the European Social Fund “Investing in your future”. Valencia: This study was funded by grants from the European Union (FP7-ENV-2011 cod 282957 and HEALTH.2010.2.4.5-1), Spain: Instituto de Salud Carlos III (Red INMA G03/176, CB06/02/0041; FIS-FEDER: PI03/1615, PI04/1509, PI04/1112, PI04/1931, PI05/1079, PI05/1052, PI06/1213, PI07/0314, PI09/02647, PI11/01007, PI11/02591, PI11/02038, PI13/1944, PI13/2032, PI14/00891, PI14/01687, PI16/1288, PI17/00663; Miguel Servet-FEDER CP11/00178, CP15/00025, CPII16/00051), Generalitat Valenciana: FISABIO (UGP 15-230, UGP-15-244, UGP-15-249), and Alicia Koplowitz Foundation 2017. Isle of Wight: This study was funded by grants from the National Institutes of Health USA (R01HL082925), Asthma UK (364), Isle of Wight NHS Trust and the British Medical Association. KOALA: The collection of data relevant for this study was funded by grants from the Netherlands Organisation for Health Research and Development (ZonMw; 2100.0090) and the Netherlands Asthma Foundation (3.2.03.48, 3.2.07.022). The researchers are independent from the funders. The funders had no role in the study design, data analysis, interpretation of data or writing of this report. We thank the children and parents for their participation in the KOALA study. LRC (Leicestershire Respiratory Cohorts): This study was funded by grants from the Swiss National Science Foundation (SNF: 320030-182628, 320030-162820, 3233-069348, 3200-069349) and Asthma UK 07/048. Lifeways Cross-Generation Cohort Study: This study was funded by the Health Research Board, Ireland, and the Irish Dept of Health and Children's Health Promotion Policy Unit. LISA: The LISA study was mainly supported by grants from the Federal Ministry for Education, Science, Research and Technology and in addition from Helmholtz Zentrum München (former GSF), Helmholtz Centre for Environmental Research – UFZ, Leipzig, Research Institute at Marien-Hospital Bad Honnef for the first 2 years. The 4-, 6-, 10- and 15-year follow-up examinations of the LISA study were covered from the respective budgets of the involved partners (Helmholtz Zentrum München (former GSF), Helmholtz Centre for Environmental Research – UFZ, Leipzig, Research Institute at Marien-Hospital Wesel, Pediatric Practice, Bad Honnef, IUF – Leibniz Research Institute for Environmental Medicine at the University of Düsseldorf) and in addition by a grant from the Federal Ministry for Environment (IUF Düsseldorf, FKZ 20462296). Further, the 15-year follow-up examination of the LISA study was supported by the Commission of the European Communities, the Seventh Framework Program: MeDALL project. This project has received funding from the European Research Council under the European Union’s Horizon 2020 research and innovation programme (949906). LucKi: LucKi is supported by Child and Youth Health Care Zuyderland, Public Health Service South Limburg and Maastricht University. We thank all parents and children for their participation in LucKi. LUKAS: This study was funded by research grants from the Academy of Finland (139021, 287675, 296814, 296817, 308254); Juho Vainio Foundation; EVO/VTR funding; Päivikki and Sakari Sohlberg Foundation; Farmers’ Social Insurance Institution (Mela); Finnish Cultural Foundation; Foundation for Pediatric Research; European Union QLK4-CT-2001-00250; and Finnish Institute for Health and Welfare, Finland. MAS-90: This study was funded by grants from the German Federal Ministry of Education and Research (MBMF; 07015633m 07ALE27, 01EE9405/5, 01EE9406) and the German Research Foundation (DFG; KE1462/2-1). Millennium Cohort Study: This study was funded by the Economic and Social Research Council and a consortium of UK government funders. We are grateful to the participating families and the Centre for Longitudinal Studies (CLS), UCL Institute of Education, for the use of these data and to the UK Data Service for making them available. However, neither CLS nor the UK Data Service bear any responsibility for the analysis or interpretation of these data. This work was supported by the Welcome Trust (187389/B/08/Z). MoBa: The Norwegian Mother, Father and Child Cohort Study is supported by the Norwegian Ministry of Health and Care Services and Ministry of Education and Research. We are grateful to all the participating families in Norway who take part in this ongoing cohort study. This research was supported by the Research Council of Norway through its Centres of Excellence funding scheme (262700). NINFEA: The authors are grateful to all the participants of the NINFEA cohort. The NINFEA study was partially funded by the Compagnia San Paolo Foundation. This research was partially funded by the European Union's Horizon 2020 research and innovation programme (LIFECYCLE, 733206). PELAGIE: We are grateful to the families who participated and continue to participate in the study. The cohort is supported by INSERM and received funding from the French National Research Agency, Fondation de France, French Agency for Food, Environmental and Occupational Health & Safety, National Institute for Public Health Surveillance (InVS), French Ministry of Labour, and French Ministry of Ecology. PIAMA: This study was funded by the Netherlands Organisation of Health Research and Development, Netherlands Organisation for Scientific Research, Netherlands Asthma Fund, Netherlands Ministry of Spatial Planning, Housing and the Environment, and Netherlands Ministry of Health, Welfare and Sport. REPRO_PL: This study was funded by the National Science Center Poland (DEC-2014/15/B/N27/00998). Rhea: This study was funded by the European Union Social Fund and the Hellenic Ministry of Health (“Program of prevention and early diagnosis of obesity and neurodevelopment disorders in preschool age children in the prefecture of Heraklion, Crete, Greece”; MIS 349580, NSRF 2007–2013). Additional funding from the National Institute of Environmental Health Sciences (NIEHS) supported L. Chatzi (R01ES030691, R01ES029944, R01ES030364, R21ES029681, R21ES028903, P30ES007048). STEPS: This study was funded by the University of Turku, Abo Akademi University, Turku University Hospital, Academy of Finland (123571, 140251, 277535) and Foundation for Pediatric Research Finland. SWS: This study was funded by the Medical Research Council, British Heart Foundation, Arthritis Research UK, Food Standards Agency, NIHR Southampton Biomedical Research Centre and the European Union's Seventh Framework Programme (FP7/2007–2013), project EarlyNutrition (289346), and the European Union's Horizon 2020 research and innovation programme (LIFECYCLE, 733206). WHISTLER: The WHISTLER birth cohort was supported with a grant from the Netherlands Organisation for Health Research and Development (2001-1-1322) and by an unrestricted grant from GlaxoSmithKline Netherlands. GlaxoSmithKline had no role in study design, in the collection, analysis and interpretation of data, in the writing of the report, and in the decision to submit the report for publication. WHISTLER-Cardio was supported with an unrestricted strategic grant from the University Medical Center Utrecht (UMCU).
Published: 2022

49. Towards a semantic annotation of microbial information using the open-source software Dataverse

Author: Beccuti, Marco, Legras, Jean-Luc, Wade, Gerard, Mineau-Cesari, Jonathan, Donetti, Simone, Contaldo, Sandro, Damiano, Rossana, Romano, Paolo, Università degli studi di Torino = University of Turin (UNITO), Sciences Pour l'Oenologie (SPO), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Montpellier, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Université de Montpellier (UM), IRCCS Istituto Giannina Gaslini [Genoa, Italy], This project has received funding from the European Union's Horizon 2020 research programme under a grant agreement No 824087, DSMZ, and European Project: 824087,EOSC-Life
Subjects: [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, [SDV]Life Sciences [q-bio]
Abstract: International audience; MIRRI-IT, the Italian Node of the Microbial Resource Research Infrastructure (MIRRI), was recognizedby the Italian government as a National Research Infrastructure in 2021. Recently, the project"Strengthening the MIRRI Italian Research Infrastructure for Sustainable Bioscience and Bioeconomy"has been funded to support its empowerment.The main objective of this project are: (a) to implement MIRRI-IT’s organisation and set up itsoperative procedures and quality standards; (b) to improve the Italian microbial Biological ResourceCenters database quality and conceive MIRRI-IT’s services based on the partners’ expertise andgenetic resources; (c) to set up a single entry point platform to promote the MIRRI-IT's resources interms of data, services, cutting-edge technologies and expertise.In this contest, the new needs for data integration and system interoperability, stressed by the FAIRapproach to data sharing, have become evident and urgent.In this work, we will present a pilot project to investigate how the semantic annotation of microbialinformation could be suitably stored using the open-source repository software Dataverse Harvard,one of the most common tools for improving data FAIRness.It will be carried out thanks to a strong collaboration between MIRRI-IT and the MIRRI task force forthe FAIRification of MIRRI-IS, potentially leading to new best practices for semantic annotation ofmicrobial information. This pilot project will be based on a Dataverse repository instance made up offive main components: the application, the database, the search engine, the file storage and theDigital Object Identifier (DOI) service.To ensure a high level of performance, security and scalability for the whole project an open-sourcecloud PaaS will be specifically developed.
Published: 2022

50. Peak metamorphic temperatures in the Alpine tectonic wedge, south Cottian Alps, Italy

Author: Lahfid, Abdeltif, Michard, André, Chopin, Christian, Schmid, S.M., Dana, D., Ballèvre, Michel, Bureau de Recherches Géologiques et Minières (BRGM) (BRGM), Université Paris-Sud - Paris 11 (UP11), Laboratoire de géologie de l'ENS (LGENS), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Département des Géosciences - ENS Paris, École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Departement Physik [ETH Zürich] (D-PHYS), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Università degli studi di Torino = University of Turin (UNITO), Géosciences Rennes (GR), Université de Rennes (UR)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR), Université de Rennes (UR)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS), Società Geologica Italiana, Université Paris-Saclay, Ecole Normale Supérieure Paris-Saclay (ENS Paris Saclay), Université Paris sciences et lettres (PSL), Institut für Geophysik [Zürich], Italian Geological Society (SGI), and Italian Society of Mineralogy and Petrology (SIMP)
Subjects: [SDU.STU.TE]Sciences of the Universe [physics]/Earth Sciences/Tectonics, Raman Spectroscopy of Carbonaceous Material (RSCM), [SDU.STU.GC]Sciences of the Universe [physics]/Earth Sciences/Geochemistry, blueschist-facies metamorphism, Western Alps, [SDU.STU.PE]Sciences of the Universe [physics]/Earth Sciences/Petrography, [SDU.STU.AG]Sciences of the Universe [physics]/Earth Sciences/Applied geology, [SDU.STU.MI]Sciences of the Universe [physics]/Earth Sciences/Mineralogy
Abstract: International audience; In the south Cottian Alps, the metamorphic wedge of the Western Alps is widely exposed. It includes, fromSW to NE, the Briançonnais internal border (Acceglio units), the ophiolitic Schistes lustrés nappes (Piemonte-Liguria Ocean) and the southern Dora-Maira units derived from the Briançonnais s.l. basement (Michard et al.,2022, and references therein). Located between the Acceglio and Dora-Maira units, the Val Maira-Sampeyreand Val Grana Allochthons (MGA) consist of a Permo-Triassic to Mid Jurassic “Prepiemonte”-type sequencedetached from the Briançonnais s.l. basement. The peak metamorphic grade of these tectonic complexesevolves from blueschist- to coesite-eclogite (Brossasco-Isasca unit of Dora-Maira). Here we report new peaktemperatures by carrying the RSCM geothermometry approach (see Lahfid et al., 2019) on most of the southCottian transect with emphasis on the MGA and on the intervening mélange shear zones. TRSCM valuesrange from ~400°C to >500°C, going from the most external Val Grana unit and overlying Queyras schiststo the uppermost Dora-Maira unit. We present a new metamorphic map and profiles based on published andnew data, including our new thermometric data. We note an overall fit between our TRSCM results and thoseinferred from the mineral assemblages, where available. The thermal anomaly linked to the rifting evolutionthat gave birth to the Piemonte-Liguria Ocean was recognized in the poorly metamorphic Adriatic margin SEof the Periadriatic line (Beltrando et al., 2015), but cannot be evidenced in the studied Briançonnais-derivedunits due to their high metamorphic grade.Beltrando M., Stockli D.F., Decarlis A. & Manatschal G. (2015) - A crustal-scale view at rift localization along the fossilAdriatic margin of the Alpine Tethys preserved in NW Italy. Tectonics, 34, 1927-1951.Lahfid A., Baidder L., Ouanaimi H., Soulaimani A., Hoepffner C., Farah A., Saddiqi O. & Michard A. (2019) - Fromextension to compression: high geothermal gradient during the earliest Variscan phase of the Moroccan Meseta; a firststructural and RSCM thermometric study. Eur. J. Mineral., 31, 695-713.Michard A., Schmid S.M., Lahfid A., Ballèvre M., Manzotti P., Chopin C., Iaccarino S. & Dana D. (2022) - The Maira-Sampeyre and Val Grana Allochthons (south Western Alps): review and new data on the tectonometamorphic evolutionof the Briançonnais distal margin. Swiss J. Geosci. (in press).
Published: 2022

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