Author: "Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)" - Searchworks@Jio Institute Digital Library Search Results

Your search keyword '"Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)"' showing total 78 results

Start Over Author "Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)"

78 results on '"Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)"'

1. Rational-Differential Design of Highly Specific Glycomimetic Ligands: Targeting DC-SIGN and Excluding Langerin Recognition

Author: Anna Bernardi, Eric Chabrol, Pedro M. Nieto, Vanessa Porkolab, Ieva Sutkeviciute, Stefania Ordanini, Eric Girard, Franck Fieschi, Michel Thépaut, Norbert Varga, María García-Jiménez, Institut de biologie structurale (IBS - UMR 5075 ), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Università degli Studi di Milano = University of Milan (UNIMI), Glycosystems Laboratory, Instituto de Investigaciones Químicas (IIQ), Universidad de Sevilla / University of Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Universidad de Sevilla / University of Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Milano [Milano] (UNIMI), and Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)
Subjects: 0301 basic medicine, Langerin, HIV Infections, Receptors, Cell Surface, medicine.disease_cause, Ligands, Biochemistry, 03 medical and health sciences, Antigen, Glycomimetic, Antigens, CD, medicine, Humans, Lectins, C-Type, Binding site, Binding Sites, biology, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], integumentary system, Chemistry, Molecular Mimicry, Rational design, Lectin, General Medicine, Dendritic Cells, 3. Good health, Cell biology, DC-SIGN, Molecular mimicry, 030104 developmental biology, Mannose-Binding Lectins, Drug Design, biology.protein, Molecular Medicine, Cell Adhesion Molecules
Abstract: At the surface of dendritic cells, C-type lectin receptors (CLRs) allow the recognition of carbohydrate-based PAMPS or DAMPS (pathogen- or danger-associated molecular patterns, respectively) and promote immune response regulation. However, some CLRs are hijacked by viral and bacterial pathogens. Thus, the design of ligands able to target specifically one CLR, to either modulate an immune response or to inhibit a given infection mechanism, has great potential value in therapeutic design. A case study is the selective blocking of DC-SIGN, involved notably in HIV trans-infection of T lymphocytes, without interfering with langerin-mediated HIV clearance. This is a challenging task due to their overlapping carbohydrate specificity. Toward the rational design of DC-SIGN selective ligands, we performed a comparative affinity study between DC-SIGN and langerin with natural ligands. We found that GlcNAc is recognized by both CLRs; however, selective sulfation are shown to increase the selectivity in favor of langerin. With the combination of site-directed mutagenesis and X-ray structural analysis of the langerin/GlcNS6S complex, we highlighted that 6-sulfation of the carbohydrate ligand induced langerin specificity. Additionally, the K313 residue from langerin was identified as a critical feature of its binding site. Using a rational and a differential approach in the study of CLR binding sites, we designed, synthesized, and characterized a new glycomimetic, which is highly specific for DC-SIGN vs langerin. STD NMR, SPR, and ITC characterizations show that compound 7 conserved the overall binding mode of the natural disaccharide while possessing an improved affinity and a strict specificity for DC-SIGN.
Published: 2017

2. Novel nickel nanoparticles stabilized by imidazolium-amidinate ligands for selective hydrogenation of alkynes

Author: Angela M. López-Vinasco, Bruno Chaudret, Pierre Lecante, Juan Cámpora, Piet W. N. M. van Leeuwen, Juan M. Asensio, Luis M. Martínez-Prieto, Laboratoire de physique et chimie des nano-objets (LPCNO), Institut de Recherche sur les Systèmes Atomiques et Moléculaires Complexes (IRSAMC), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie de Toulouse (ICT-FR 2599), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut de Chimie du CNRS (INC), Instituto de Tecnología Química (ITQ), Universitat Politècnica de València (UPV)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Centre d'élaboration de matériaux et d'études structurales (CEMES), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut de Chimie du CNRS (INC)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA), Instituto de Investigaciones Químicas (IIQ), Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche sur les Systèmes Atomiques et Moléculaires Complexes (IRSAMC), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Universidad de Sevilla / University of Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Ministerio de Ciencia, Innovación y Universidades (España), European Commission, Consejo Superior de Investigaciones Científicas (España), Agencia Estatal de Investigación (España), Centre National de la Recherche Scientifique (France), and Université Toulouse III Paul Sabatier
Subjects: Materials science, [CHIM.ORGA]Chemical Sciences/Organic chemistry, 010405 organic chemistry, chemistry.chemical_element, [CHIM.CATA]Chemical Sciences/Catalysis, 010402 general chemistry, 01 natural sciences, Medicinal chemistry, Catalysis, 0104 chemical sciences, Nickel, QUIMICA ORGANICA, chemistry, media_common.cataloged_instance, European union, media_common
Abstract: [EN] The main challenge in the hydrogenation of alkynes into (E)- or (Z)-alkenes is to control the selective formation of the alkene, avoiding the over-reduction to the corresponding alkane. In addition, the preparation of recoverable and reusable catalysts is of high interest. In this work, we report novel nickel nanoparticles (Ni NPs) stabilized by three different imidazolium-amidinate ligands (ICy center dot(NCN)-N-(Ar); L1: Ar = p-tol, L2: Ar = p-anisyl and L3: Ar = p-ClC6H4). The as-prepared Ni NPs were fully characterized by (HR)-TEM, XRD, WASX, XPS and VSM. The nanocatalysts are active in the hydrogenation of various substrates. They present a remarkable selectivity in the hydrogenation of alkynes towards (Z)-alkenes, particularly in the hydrogenation of 3-hexyne into (Z)-3-hexene under mild reaction conditions (room temperature, 3% mol Ni and 1 bar H-2). The catalytic behaviour of Ni NPs was influenced by the electron donor/acceptor groups (-Me, -OMe, -Cl) in the N-aryl substituents of the amidinate moiety of the ligands. Due to the magnetic character of the Ni NPs, recycling experiments were successfully performed after decantation in the presence of an external magnet, which allowed us to recover and reuse these catalysts at least 3 times preserving both activity and chemoselectivity., The authors thank CNRS, UPS-Toulouse, INSA, "IDEX/Chaires d'attractivite l'Universite Federale Toulouse Midi-Pyrenees", "Instituto de Tecnologia Quimica" (ITQ; UPV-CSIC), "Juan de la Cierva" programme (IJCI-2016-27966), "Primero Proyectos de Investigacion" (PAID-06-18), "Instituto de Investigaciones Quimicas" (IIQ; CSIC-US), "Ministerio de Ciencia, Innovacion y Universidades" (MCIU/AEI), FEDER funds of the European Union (PGC2018-095768-B-I00) and ERC Advanced Grant (MONACAT 2015-694159) for financial support. We also thank L. Datas for the TEM facilities (UMS Castaing) and S. Cayez for the HRTEM measurements.
Published: 2020

3. Simultaneous Optical and Electrical Characterization of GaN Nanowire Arrays by Means of Vis-IR Spectroscopic Ellipsometry

Author: S. Hurand, F. Paumier, Bertrand Lacroix, Victor J. Gómez, Antonio J. Santos, Rafael García, Francisco M. Morales, Thierry Girardeau, Diana L. Huffaker, Eduardo Blanco, Fraunhofer AICOS [Porto], Instituto de Ciencia de Materiales de Sevilla (ICMSE), Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Spain] (CSIC), Universidad Simon Bolivar (USB), Physique et Propriétés des Nanostructures PPNa (PPNa), Département Physique et Mécanique des Matériaux (Département Physique et Mécanique des Matériaux), Institut Pprime (PPRIME), Université de Poitiers-Centre National de la Recherche Scientifique (CNRS)-ENSMA-Université de Poitiers-Centre National de la Recherche Scientifique (CNRS)-ENSMA-Institut Pprime (PPRIME), Université de Poitiers-Centre National de la Recherche Scientifique (CNRS)-ENSMA-Université de Poitiers-Centre National de la Recherche Scientifique (CNRS)-ENSMA, Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7), Université de Montréal [Montréal], Fraunhofer Center for Assistive Information and Communication Solutions [Porto] (Fraunhofer AICOS), Fraunhofer (Fraunhofer-Gesellschaft), Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Université de Poitiers-ENSMA-Centre National de la Recherche Scientifique (CNRS)-Université de Poitiers-ENSMA-Centre National de la Recherche Scientifique (CNRS)-Institut Pprime (PPRIME), Université de Poitiers-ENSMA-Centre National de la Recherche Scientifique (CNRS)-Université de Poitiers-ENSMA-Centre National de la Recherche Scientifique (CNRS), Université de Montréal (UdeM), Universidad de Sevilla / University of Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Astrophysique Interprétation Modélisation (AIM (UMR7158 / UMR_E_9005 / UM_112)), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Diffraction, Materials science, Silicon, Infrared, [PHYS.MPHY]Physics [physics]/Mathematical Physics [math-ph], Nanowire, Physics::Optics, chemistry.chemical_element, 02 engineering and technology, 010402 general chemistry, Epitaxy, 01 natural sciences, Nitrides, [SPI.AUTO]Engineering Sciences [physics]/Automatic, Condensed Matter::Materials Science, [PHYS.QPHY]Physics [physics]/Quantum Physics [quant-ph], Hall effect, Ellipsometry, [PHYS.MECA.MEFL]Physics [physics]/Mechanics [physics]/Fluid mechanics [physics.class-ph], [PHYS.MECA.BIOM]Physics [physics]/Mechanics [physics]/Biomechanics [physics.med-ph], Physical and Theoretical Chemistry, Oscillation Mobility, [SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], [PHYS.MECA.VIBR]Physics [physics]/Mechanics [physics]/Vibrations [physics.class-ph], [PHYS.MECA.MEFL]Physics [physics]/Mechanics [physics]/Mechanics of the fluids [physics.class-ph], Nanowires, business.industry, [SPI.FLUID]Engineering Sciences [physics]/Reactive fluid environment, [SPI.NRJ]Engineering Sciences [physics]/Electric power, [CHIM.MATE]Chemical Sciences/Material chemistry, [PHYS.MECA.MSMECA]Physics [physics]/Mechanics [physics]/Materials and structures in mechanics [physics.class-ph], 021001 nanoscience & nanotechnology, [PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], 0104 chemical sciences, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Characterization (materials science), [SPI.ELEC]Engineering Sciences [physics]/Electromagnetism, [CHIM.POLY]Chemical Sciences/Polymers, General Energy, chemistry, [PHYS.MECA.THER]Physics [physics]/Mechanics [physics]/Thermics [physics.class-ph], Optoelectronics, 0210 nano-technology, business, Porosity
Abstract: International audience; We report an original and straightforward method for both optical and electrical characterization of vertical GaN nanowire arrays epitaxially grown on silicon through visible-infrared spectroscopic ellipsometry methods. For the initial purpose of adding new inputs to the ellipsometry model, focused ion-beam tomography experiments were conducted to extract porosity/depth profiles of these systems. To reproduce the optical free-carrier behavior in the infrared, the ellipsometric data acquired were fitted to an anisotropic Bruggeman model including Tauc-Lorentz and Drude oscillators, which enabled the determination of carrier density and in-grain mobility. The nice agreement of these results with those obtained by combining Hall effect measurements, X-ray diffraction, and transmission electron microscopy studies supported the validity of the proposed method, opening new horizons in the characterization of nanowire-based semiconducting layers.
Published: 2019

4. Dynamics of carbon diffusion and segregation through nickel catalyst, investigated by in-situ XPS, during the growth of nitrogen-doped graphene

Author: Anne-Sophie Loir, Florent Bourquard, C. Donnet, Frédéric Christien, Florence Garrelie, Y. Bleu, Vincent Barnier, Laboratoire Hubert Curien [Saint Etienne] (LHC), Institut d'Optique Graduate School (IOGS)-Université Jean Monnet [Saint-Étienne] (UJM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Georges Friedel (LGF-ENSMSE), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Département Mécanique physique et interfaces (MPI-ENSMSE), École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-SMS, Centre Science des Matériaux et des Structures (SMS-ENSMSE), Institut Mines-Télécom [Paris] (IMT), Instituto de Ciencia de Materiales de Sevilla (ICMSE), Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Université Jean Monnet [Saint-Étienne] (UJM)-Centre National de la Recherche Scientifique (CNRS)-Institut d'Optique Graduate School (IOGS), and Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)
Subjects: Nitrogen-doped graphene, Materials science, Annealing (metallurgy), Pulsed laser deposition, chemistry.chemical_element, 02 engineering and technology, Chemical vapor deposition, 010402 general chemistry, 01 natural sciences, [SPI.MAT]Engineering Sciences [physics]/Materials, Catalysis, law.invention, Diffusion, chemistry.chemical_compound, law, General Materials Science, Carbon nitride, Graphene, Segregation, General Chemistry, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Amorphous solid, Nickel, chemistry, Chemical engineering, In situ XPS, 0210 nano-technology
Abstract: International audience; The mechanisms of diffusion and segregation of carbon from a solid carbon-based film, through a nickel film catalyst, was investigated using in situ, time- and depth-resolved X-ray photoelectron spectroscopy. The graphene precursor was a carbon nitride amorphous film obtained by pulse laser deposition. Changes in both surface and bulk sensitive carbon components versus annealing time was investigated at temperatures between 200 °C and 500 °C. A model of carbon diffusion/segregation through the nickel film was implemented, enabling the quantitative description of the graphene growth. Carbon diffusion through the nickel film was shown to occur at low temperatures (200–300 °C) and to induce the growth of graphene domains. The fine microstructure and high density of defects in the nickel catalyst film accelerated the transport of carbon, faster than conventional bulk diffusion. At 500 °C, bulk diffusion of carbon occurred, due to the recovering of the nickel grain microstructure. The diffusion/segregation model developed in this study can be used as a support to a better control of the growth and quality of the graphene. Our interpretations are discussed in relation to similar approaches related to graphene growth by chemical vapor deposition.
Published: 2019

5. A binuclear cobalt complex for molecular CO$_2$ electrocatalysis

Author: Antoine Bohn, Juan José Moreno, Pierre Thuéry, Marc Robert, Orestes Rivada Wheelaghan, Laboratoire d'Electrochimie Moléculaire (LEM (UMR_7591)), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Instituto de Investigaciones Químicas (IIQ), Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Laboratoire de Chimie Moléculaire et de Catalyse pour l'Energie (ex LCCEF) (LCMCE), Nanosciences et Innovation pour les Matériaux, la Biomédecine et l'Energie (ex SIS2M) (NIMBE UMR 3685), Institut Rayonnement Matière de Saclay (IRAMIS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Institut Rayonnement Matière de Saclay (IRAMIS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), ANR-18-MPGA-0012,CAMELEON,Méthodes moléculaires pour le stockage d'énergie et la production de carburant(2018), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Universidad de Sevilla / University of Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut Rayonnement Matière de Saclay (IRAMIS), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Spectro–electrochemistry, Bimetallic, 13. Climate action, Cobalt, [CHIM.MATE]Chemical Sciences/Material chemistry, Carbon Dioxide, Electrocatalysis, 3. Good health
Abstract: A pyrazole–based ligand substituted with terpyridine groups at the 3 and 5positions has been synthesized to form the dinuclear cobalt complex 1, that electrocatalytically reduces carbon dioxide (CO2) to carbon monoxide (CO) in the presence of Brønsted acids in DMF. Chemical, electrochemical and UV–vis spectro–electrochemical studies under inert atmosphere indicate a single 2 electron reduction process of complex 1 at first, followed by a 1 electron reduction at the ligand. Infrared spectro–electrochemical studies under CO2 and CO atmosphere allowed us to identify a reduced CO–containing dicobalt complex which results from the electroreduction of CO2. In the presence of trifluoroethanol (TFE), electrocatalytic studies revealed single–site mechanism with up to 94 % selectivity towards CO formation when 1.47 M TFE were present, at –1.35 V vs Saturated Calomel Electrode in DMF (0.39 V overpotential). The low faradaic efficiencies obtained (
Published: 2021

6. Helium-charged aluminum and silicon films deposited by Direct Current Magnetron Sputtering

Author: Ibrahim, Sara, Brault, Pascal, caillard, amael, Sauvage, Thierry, Desgardin, Pierre, Barthe, M.F., Hufschmidt, D, Fernandez, Asuncion, Thomann, A.L., Groupe de recherches sur l'énergétique des milieux ionisés (GREMI), Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS), Conditions Extrêmes et Matériaux : Haute Température et Irradiation (CEMHTI), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université d'Orléans (UO), Instituto de Ciencia de Materiales de Sevilla (ICMSE), Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), and Brault, Pascal
Subjects: [SPI.PLASMA]Engineering Sciences [physics]/Plasmas, [SPI.PLASMA] Engineering Sciences [physics]/Plasmas, [SPI.MAT] Engineering Sciences [physics]/Materials, ComputingMilieux_MISCELLANEOUS, [SPI.MAT]Engineering Sciences [physics]/Materials
Abstract: International audience
Published: 2021

7. Relationship Between Different Resistance Mechanisms and Virulence in Acinetobacter baumannii

Author: Rafael López-Rojas, Jordi Vila, Sara Martí, Dora Rolo, Alix Pantel, Younes Smani, Paula Espinal, Jean-Philippe Lavigne, Jerónimo Pachón, European Society of Clinical Microbiology and Infectious Diseases, Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica, Instituto de Salud Carlos III, Instituto de Salud Global - Institute For Global Health [Barcelona] (ISGlobal), Virulence bactérienne et maladies infectieuses (VBMI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Service de Microbiologie [CHU Caremeau, Nîmes], Hôpital Universitaire Carémeau [Nîmes] (CHU Nîmes), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Institut d'Investigació Biomèdica de Bellvitge [Barcelone] (IDIBELL), CIBER Epidemiologia y Salud Pùblica [Madrid, Spain] (CIBERESP), Instituto de Salud Carlos III [Madrid] (ISC), Instituto de Biomedicina de Sevilla [Sevilla, Spain] (IBIS/HUVR), Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Hospital Universitario Virgen del Rocío [Sevilla], and Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)
Subjects: Acinetobacter baumannii, Microbiology (medical), Immunology, Virulence, macromolecular substances, Multidrug resistance, Microbiology, Impermeability, Carbapenemase, carbapenemase, 03 medical and health sciences, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, polycyclic compounds, Caenorhabditis elegans, 030304 developmental biology, Pharmacology, 0303 health sciences, biology, 030306 microbiology, [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences, biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses, Carbapenemases, biology.organism_classification, 3. Good health, Multiple drug resistance, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, bacteria, MESH: Anti-Bacterial Agents / pharmacology, Acinetobacter Baumanii / genetics, Lipopolysaccharides / deficiency, Mutation
Abstract: [Aim] This study analyzed the virulence of several Acinetobacter baumannii strains expressing different resistance mechanisms using the Caenorhabditis elegans infection model., [Results] Strains susceptible/resistant to carbapenems (presenting class D (OXA-23, OXA-24), class B metallo-β-lactamase (MBL) (NDM-1), penicillin binding protein (PBP) altered and decreased expression of Omp 33–36 kDa) and isogenic A. baumannii strains susceptible/resistant to colistin (presenting loss of lipopolysaccharide (LPS) and pmrA mutations) were included to evaluate the virulence using the C. elegans infection model. The nematode killing assay, bacterial ingestion in worms, and bacterial lawn avoidance assay were performed with the Fer-15 mutant line. A. baumannii strains generally presented low virulence, showing no difference between carbapenem-resistant strains (expressing class D, MBLs, or altered PBP) and their isogenic susceptible strains. In contrast, the absence of the Omp 33–36 kDa protein in the knockout was associated with a decrease of virulence, and a significant difference was observed between colistin-resistant mutants and their susceptible counterpart when the mechanism of resistance was associated with the loss of LPS but not with its modification., [Conclusions] Resistance to carbapenems in A. baumannii associated with the production of OXA-type or NDM-type enzymes does not seem to affect their virulence in the C. elegans infection model. In contrast, the presence of Omp 33–36 kDa, and high level resistance to colistin related with the loss of LPS, might contribute with the virulence profile in A. baumannii., This work was supported by INSERM, the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) under Research Grant (2013) to PE, the Spanish Society of Clinical Microbiology and Infectious Diseases (SEIMC) under travel grant to PE, and the Instituto de Salud Carlos III (ISCIII), Madrid, Spain under “Sara Borrell” Postdoctoral Contract CD12/00482 to DR and CD15/00017 to PE.
Published: 2019

8. Influence of helium incorporation on growth process and properties of aluminum thin films deposited by DC magnetron sputtering

Author: Sara Ibrahim, Agnès Petit, Pascal Brault, Fatima Zahrae Lahboub, Amaël Caillard, Asunción Fernández, Anne-Lise Thomann, Thierry Sauvage, Eric Millon, Groupe de recherches sur l'énergétique des milieux ionisés (GREMI), Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS), Conditions Extrêmes et Matériaux : Haute Température et Irradiation (CEMHTI), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université d'Orléans (UO), Instituto de Ciencia de Materiales de Sevilla (ICMSE), and Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)
Subjects: Materials science, Analytical chemistry, chemistry.chemical_element, Substrate (electronics), 01 natural sciences, 010305 fluids & plasmas, Crystallinity, Sputtering, 0103 physical sciences, Materials Chemistry, Thin film, Nanostructured aluminum films, Helium, Deposition (law), 010302 applied physics, Argon, porous thin films, Surfaces and Interfaces, General Chemistry, [CHIM.MATE]Chemical Sciences/Material chemistry, Sputter deposition, Condensed Matter Physics, Surfaces, Coatings and Films, helium/argon mixture plasma, chemistry, direct current magnetron sputtering
Abstract: International audience; The effect of helium content on the morphology, crystallinity, and composition of aluminum films was investigated by depositing He-loaded Al films onto Si substrates via direct current (DC) magnetron sputtering in different Ar/He plasma mixtures. Three different plasma regimes were identified depending on the percentage of He in the gas phase. For a low He to total gas ratio (ΓHe ≤ 70%), the plasma is dominated by argon, where Ar + ions contribute to sputter out the target atoms. The films deposited in this regime exhibited the classical dense columnar structure and contain very low amount of He (below 2%). Then, as ΓHe increases, helium ions 2 begin to be formed and more fast He neutrals reach the substrate, affecting the film growth. As He amount increased in the gas phase up to 95%, the proportion of He inserted in the films rised up to ⁓ 15 at.%. Moreover, bubbles/porosity were formed inside the films; those obtained in pure He plasma presented a highly porous fiberform nanostructure. All results confirmed that the modification of the film characteristics was related to the change of the deposition conditions when Ar was replaced by He and to the insertion/release mechanisms of He during the growth.
Published: 2021

9. The wrinkling concept applied to plasma‐deposited polymer‐like thin films: A promising method for the fabrication of flexible electrodes

Author: Thomas Godfroid, Sylvain Desprez, Nathan Vinx, Damien Thiry, Francisco J. Aparicio, David Moerman, Pierre-Yves Tessier, Philippe Leclère, Pascal Damman, Rony Snyders, Centre d'Innovation et de Recherche en Matériaux Polymères (CIRMAP), Université de Mons (UMons), Instituto de Ciencia de Materiales de Sevilla (ICMSE), Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Institut des Matériaux Jean Rouxel (IMN), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Ecole Polytechnique de l'Université de Nantes (EPUN), Université de Nantes (UN)-Université de Nantes (UN), MateriaNova Research Center (MNRS), and Université de Mons-Hainaut
Subjects: 010302 applied physics, chemistry.chemical_classification, Materials science, Fabrication, Polymers and Plastics, Nanotechnology, 02 engineering and technology, Plasma, Polymer, 021001 nanoscience & nanotechnology, Condensed Matter Physics, 01 natural sciences, chemistry, 0103 physical sciences, Electrode, [PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci], Thin film, 0210 nano-technology, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2020

10. ICTAC Kinetics Committee recommendations for analysis of multi-step kinetic

Author: Vyazovkin, Sergey, K. Burnham, Alan, Favergeon, Loïc, Koga, Nobuyoshi, Moukhina, Elena, A.Pérez-Maqueda, Luis, Sbirrazzuoli, Nicolas, Department of Chemistry, University of Alabama at Birmingham [ Birmingham] (UAB), Alan Burnham Consultant, Département Procédés de Transformations des Solides et Instrumentation (PTSI-ENSMSE), Centre Sciences des Processus Industriels et Naturels (SPIN-ENSMSE), École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Laboratoire Georges Friedel (LGF-ENSMSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Graduate School of Education, Hiroshima University, Department of Science Education, NETZSCH-Gerätebau GmbH, Instituto de Ciencia de Materiales de Sevilla (ICMSE), Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Universidad de Sevilla, Université Côte d'Azur (UCA), Institut de Chimie de Nice (ICN), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), University of Alabama at Birmingham - Department of Chemistry, Hiroshima University - Graduate School of Education - Department of Science Education, C.S.I.C–Universidad de Sevilla - Instituto de Ciencia de Materiales de Sevilla, and Institut de Chimie de Nice - Université Côte d'Azur
Subjects: decomposition, crystallization, polymerization, [SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering, pyrolysis, degradation
Abstract: International audience; The present recommendations have been developed by the Kinetics Committee of the International Confederation for Thermal Analysis and Calorimetry (ICTAC). The recommendations provide guidance on kinetic analysis of multi-step processes as measured by thermal analysis methods such as thermogravimetry (TGA) and differential scanning calorimetry (DSC). Ways of detecting the multi-step kinetics are discussed first. Then, four different approaches to evaluation of kinetic parameters (the activation energy, the pre-exponential factor, and the reaction model) for individual steps are considered. The approaches considered include multi-step model-fitting as well as distributed reactivity, isoconversional, and deconvolution analyses. For each approach practical advice is offered on its effective usage. Due attention is also paid to the typical problems encountered and to the ways of resolving them. The objective of these recommendations is to help a non-expert with efficiently performing multi-step kinetic analysis and interpreting its results.
Published: 2020

11. Downregulation of thioredoxin-1-dependent CD95 S-nitrosation by Sorafenib reduces liver cancer

Author: Sergio Rius-Pérez, Carmen Choya-Foces, Jordi Muntané, María A. Rodríguez-Hernández, Antonio Miranda-Vizuete, C. Alicia Padilla, Raúl González, Antonio Martínez-Ruiz, Juan Sastre, María Negrete, Patricia de la Cruz-Ojeda, Kalina Ranguelova, Anne-Odile Hueber, José Antonio Bárcena, Aurélie Rossin, [González,R, Rodríguez-Hernández,MA, Negrete,M, de la Cruz-Ojeda,P, Miranda-Vizuete,A, Muntané,J] Institute of Biomedicine of Seville (IBiS), Hospital University 'Virgen Del Rocío'/CSIC/University of Seville, Seville, Spain. [Ranguelova,K] Bruker BioSpin Corporation, Billerica, MA, USA. [Rossin,A, Hueber,AO] Université Côte D'Azur, CNRS, Inserm, iBV, Nice, France. [Choya-Foces,C, Martínez-Ruiz,A] Research Unit, Hospital University 'Santa Cristina', Health Research Institute 'La Princesa' (IIS-IP), Madrid, Spain. [Choya-Foces,C, Martínez-Ruiz,A] Biomedical Research Network Center for Cardiovascular Diseases (CIBERCV), Madrid, Spain. [Rius-Pérez,S, Sastre,J] Department of Physiology, Faculty of Pharmacy, University of Valencia. Burjassot, Valencia, Spain. [Bárcena,JA, Padilla,CA] Department of Biochemistry and Molecular Biology, University of Cordoba, Cordoba, Spain. [Bárcena,JA, Padilla,CA] Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), Cordoba, Spain. [Muntané,J] Department of General Surgery, Hospital University 'Virgen del Rocío'/IBiS/CSIC/University of Seville, Seville, Spain. [González,R, Muntané,J] Biomedical Research Network Center for Liver and Digestive Diseases (CIBERehd), Madrid, Spain., This study was funded by Institute of Health Carlos III (ISCIII) (PI13/00021, PI15/00107, PI16/00090 and PI19/01266), Spanish Ministry of Economy and Competitiveness (SAF2015-71208-R, BFU2016-8006-P, PGC2018-094276-B-I00 and RED2018-102576-T), Andalusian Ministry of Economy, Innovation, Science and Employment (BIO-216 and CTS-6264) and Andalusian Ministry of Equality, Health and Social Policies (PI-00025-2013 and PI-0198-2016). P de la C–O was supported by FPU predoctoral fellowship (FPU17/00026) from Ministry of Education, Culture and Sports. We thank the Biomedical Research Network Center for Cardiovascular Diseases (CIBERCV), and the Biomedical Research Network Center for Liver and Digestive Diseases (CIBERehd) founded by the ISCIII and co-financed by European Development Regional Fund 'A way to achieve Europe' ERDF for their financial support., Institute of Biomedicine of Seville (IBIS), Bruker Biospin Corporation, Billerica, Institut de Biologie Valrose (IBV), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Santa Cristina University Hospital, University of Valencia, Valencia, University of Córdoba [Córdoba], Instituto de Biomedicina de Sevilla [Sevilla, Spain] (IBIS/HUVR), Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Servicio de Immunologia, Hospital Universitario de la Princesa-Instituto de Investigacion Sanitaria Princesa, Instituto de Salud Carlos III, Ministerio de Ciencia, Innovación y Universidades (España), Ministerio de Economía y Competitividad (España), Junta de Andalucía, Ministerio de Educación, Cultura y Deporte (España), Centro de Investigación Biomédica en Red Enfermedades Cardiovaculares (España), Centro de Investigación Biomédica en Red Enfermedades Hepáticas y Digestivas (España), and European Commission
Subjects: 0301 basic medicine, Anatomy::Cells::Cells, Cultured::Cell Line::Cell Line, Tumor [Medical Subject Headings], Factor 2 relacionado con NF-E2, Regulación hacia abajo, medicine.medical_treatment, [SDV]Life Sciences [q-bio], Clinical Biochemistry, Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Thioredoxins [Medical Subject Headings], Apoptosis, Biochemistry, Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::Nitrosation [Medical Subject Headings], Targeted therapy, Neoplasias hepáticas, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Mice, 0302 clinical medicine, Thioredoxins, Organisms::Eukaryota::Animals [Medical Subject Headings], lcsh:QH301-705.5, Cell proliferation, lcsh:R5-920, GSNOR, Chemistry, Diseases::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Liver Neoplasms [Medical Subject Headings], Liver Neoplasms, Sorafenib, Fas receptor, 3. Good health, Hepatocellular carcinoma, CD95, Liver cancer, lcsh:Medicine (General), NOS3, Carcinoma hepatocelular, Research Paper, medicine.drug, Hepatocarcinoma, Proliferación celular, Carcinoma, Hepatocellular, Nitrosation, Down-Regulation, Mice, Nude, [SDV.CAN]Life Sciences [q-bio]/Cancer, Antineoplastic Agents, Nrf2, 03 medical and health sciences, Downregulation and upregulation, Cell Line, Tumor, medicine, Animals, Humans, S-Nitrosoglutatión, Tiorredoxinas, Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Growth Processes::Cell Proliferation [Medical Subject Headings], Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice [Medical Subject Headings], Diseases::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Liver Neoplasms::Carcinoma, Hepatocellular [Medical Subject Headings], Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::Down-Regulation [Medical Subject Headings], Cell growth, Phenylurea Compounds, Organic Chemistry, Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Antineoplastic Agents [Medical Subject Headings], [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice::Mice, Mutant Strains::Mice, Nude [Medical Subject Headings], medicine.disease, digestive system diseases, 030104 developmental biology, lcsh:Biology (General), Downregulation, Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Hydrocarbons, Cyclic::Hydrocarbons, Aromatic::Benzene Derivatives::Phenylurea Compounds [Medical Subject Headings], [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, Cancer research, Óxido nítrico sintasa de tipo III, 030217 neurology & neurosurgery
Abstract: Hepatocellular carcinoma (HCC) represents 80% of the primary hepatic neoplasms. It is the sixth most frequent neoplasm, the fourth cause of cancer-related death, and 7% of registered malignancies. Sorafenib is the first line molecular targeted therapy for patients in advanced stage of HCC. The present study shows that Sorafenib exerts free radical scavenging properties associated with the downregulation of nuclear factor E2-related factor 2 (Nrf2)-regulated thioredoxin 1 (Trx1) expression in liver cancer cells. The experimental downregulation and/or overexpression strategies showed that Trx1 induced activation of nitric oxide synthase (NOS) type 3 (NOS3) and S-nitrosation (SNO) of CD95 receptor leading to an increase of caspase-8 activity and cell proliferation, as well as reduction of caspase-3 activity in liver cancer cells. In addition, Sorafenib transiently increased mRNA expression and activity of S-nitrosoglutathione reductase (GSNOR) in HepG2 cells. Different experimental models of hepatocarcinogenesis based on the subcutaneous implantation of HepG2 cells in nude mice, as well as the induction of HCC by diethylnitrosamine (DEN) confirmed the relevance of Trx1 downregulation during the proapoptotic and antiproliferative properties induced by Sorafenib. In conclusion, the induction of apoptosis and antiproliferative properties by Sorafenib were related to Trx1 downregulation that appeared to play a relevant role on SNO of NOS3 and CD95 in HepG2 cells. The transient increase of GSNOR might also participate in the deactivation of CD95-dependent proliferative signaling in liver cancer cells., Graphical abstract Graphical Abstract. Sorafenib reduced ROS/RNS cytoplasmic concentrations which were associated with decreased Nrf2 nuclear translocation, Trx1 expression/activity, and SNO–NOS3 expression and NO intracellular generation in HepG2. The reduction of SNO–NOS3 expression and NO generation might also be influenced by the induction of transient GSNOR expression/activity and reduced NOS3 expression by Sorafenib. The diminution of SNO-CD95 expression by Sorafenib involved reduction of caspase-8 activity and cell proliferation, and increased downstream caspase-3 activity in liver cancer cells.Image 1, Highlights • Sorafenib induces mitochondrial ROS generation, but also acts as nucleophilic scavenger. • Sorafenib reduces Nrf2-depenent Trx1 expression, and SNO–NOS3 and SNO-CD95 ratios. • Sorafenib-related antitumoral in vivo activity involves diminution of Trx1 and SNO-CD95.
Published: 2020

12. Combined MEK and PI3K/p110b inhibition as a novel targeted therapy for malignant mesothelioma displaying sarcomatoid features

Author: Christine Pirker, Natalia del Pozo, Francisco X. Real, Jaime Martinez de Villarreal, Clément Meiller, Amancio Carnero, Luis C. Fernández, Walter Berger, Yuna Blum, Miriam Marqués, Didier Jean, Enrique Carrillo-de-Santa-Pau, Balazs Hegedus, Yves Allory, Blanca Risa-Ebrí, María L. Suárez-Solís, Simon T. Barry, Robin Tranchant, Epithelial Carcinogenesis Group [Madrid, Spain], Spanish National Cancer Research Center (CNIO), Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Instituto de Investigación Sanitaria del Hospital Clínico San Carlos [Madrid, Spain] (IdISSC), Universidad Europea de Madrid, IMDEA Food Institute [Madrid, Spain], Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-IFR10, (le programme) Cartes d'identité des tumeurs (CIT), Ligue Nationales Contre le Cancer (LNCC), Comprehensive Cancer Center [Vienna, Austria], Institute of Cancer Research [Vienna, Austria]-Medizinische Universität Wien = Medical University of Vienna, Medizinische Universität Wien = Medical University of Vienna, IMED Oncology [Cambridge, UK] (AstraZeneca), Li Ka Shing Centre [Cambridge, UK], Instituto de Biomedicina de Sevilla [Sevilla, Spain] (IBIS/HUVR), Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Departament de Ciències Experimentals i de la Salut [Barcelona, Spain], Universitat Pompeu Fabra [Barcelona] (UPF), This work was supported, in part, by grants from Asociación Española Contra el Cáncer (FXR), Spanish Ministry of Economy and Competitivity, Plan Estatal de I+D+I 2013-2016, ISCIII (FIS PI15/00045) (AC), RTICC (Instituto de Salud Carlos III, grants RD12/0036/0034 to FXR and AC, respectively), and CIBERONC (CB16/12/00453 and CD16/12/00275 to FXR and AC, respectively), cofunded by FEDER from Regional Development European Funds (European Union) and Inserm (Institut national de la santé et de la recherche médicale). MM was supported by a Sara Borrell Fellowship from Instituto de Salud Carlos III. CNIO is supported by Ministerio de Ciencia, Innovación y Universidades as a Centro de Excelencia Severo Ochoa SEV-2015-0510., Jean, Didier, Universidad Europea de Madrid = European University of Madrid (UEM), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Medizinische Universität Wien = Medical University of Vienna-Institute of Cancer Research [Vienna, Austria], Universidad de Sevilla / University of Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Asociación Española Contra el Cáncer, Ministerio de Economía y Competitividad (España), Instituto de Salud Carlos III, Red Temática de Investigación Cooperativa en Cáncer (España), and European Commission
Subjects: Mesothelioma, 0301 basic medicine, MAPK/ERK pathway, Cancer Research, Lung Neoplasms, medicine.medical_treatment, Vimentin, [SDV.BBM.BM] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, PI3K, Epithelium, Targeted therapy, Mice, 0302 clinical medicine, Antineoplastic Combined Chemotherapy Protocols, Gene Knock-In Techniques, Molecular Targeted Therapy, Peritoneal Neoplasms, Mice, Knockout, Aniline Compounds, biology, Cáncer, Prognosis, 3. Good health, Oncology, Terapia, 030220 oncology & carcinogenesis, Pleura, [SDV.BBM.GTP] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], Female, Peritoneum, Class I Phosphatidylinositol 3-Kinases, Pleural Neoplasms, Primary Cell Culture, [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, [SDV.GEN.GH] Life Sciences [q-bio]/Genetics/Human genetics, GPCRs, 03 medical and health sciences, [SDV.CAN] Life Sciences [q-bio]/Cancer, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], medicine, Animals, Humans, PTEN, Protein Kinase Inhibitors, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, PI3K/AKT/mTOR pathway, Cell Proliferation, Mitogen-Activated Protein Kinase Kinases, business.industry, Mesothelioma, Malignant, PTEN Phosphohydrolase, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, medicine.disease, Sarcomatoid Mesothelioma, MAPK, Disease Models, Animal, Mesotelioma, 030104 developmental biology, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, Chromones, biology.protein, Selumetinib, Cancer research, Benzimidazoles, Tumor Suppressor Protein p53, sarcomatoid mesothelioma, business
Abstract: Among malignant mesotheliomas (MM), the sarcomatoid subtype is associated with higher chemoresistance and worst survival. Due to its low incidence, there has been little progress in the knowledge of the molecular mechanisms associated with sarcomatoid MM, which might help to define novel therapeutic targets. In this work, we show that loss of PTEN expression is frequent in human sarcomatoid MM and PTEN expression levels are lower in sarcomatoid MM than in the biphasic and epithelioid subtypes. Combined Pten and Trp53 deletion in mouse mesothelium led to nonepithelioid MM development. In Pten;Trp53-null mice developing MM, the Gαi2-coupled receptor subunit activated MEK/ERK and PI3K, resulting in aggressive, immune-suppressed tumors. Combined inhibition of MEK and p110β/PI3K reduced mouse tumor cell growth in vitro. Therapeutic inhibition of MEK and p110β/PI3K using selumetinib (AZD6244, ARRY-142886) and AZD8186, two drugs that are currently in clinical trials, increased the survival of Pten;Trp53-null mice without major toxicity. This drug combination effectively reduced the proliferation of primary cultures of human pleural (Pl) MM, implicating nonepithelioid histology and high vimentin, AKT1/2, and Gαi2 expression levels as predictive markers of response to combined MEK and p110β/PI3K inhibition. Our findings provide a rationale for the use of selumetinib and AZD8186 in patients with MM with sarcomatoid features. This constitutes a novel targeted therapy for a poor prognosis and frequently chemoresistant group of patients with MM, for whom therapeutic options are currently lacking., [Significance] Mesothelioma is highly aggressive; its sarcomatoid variants have worse prognosis. Building on a genetic mouse model, a novel combination therapy is uncovered that is relevant to human tumors., This work was supported, in part, by grants from Asociación Española Contra el Cáncer (F.X. Real), Spanish Ministry of Economy and Competitivity, Plan Estatal de I+D+I 2013-2016, ISCIII (FIS PI15/00045 to A. Carnero), RTICC (Instituto de Salud Carlos III, grants RD12/0036/0034 to F.X. Real and A. Carnero, respectively), and CIBERONC (CB16/12/00453 and CD16/12/00275 to F.X. Real and A. Carnero, respectively), cofunded by FEDER from Regional Development European Funds (European Union) and Inserm (Institut national de la santé et de la recherche médicale). M. Marqués was supported by a Sara Borrell Fellowship from Instituto de Salud Carlos III. CNIO is supported by Ministerio de Ciencia, Innovación y Universidades as a Centro de Excelencia Severo Ochoa SEV-2015-0510.
Published: 2020

13. Protonation of the Cysteine Axial Ligand Investigated in His/Cys c-Type Cytochrome by UV-Vis and Mid- And Far-IR Spectroscopy

Author: Irene Díaz-Moreno, Alain Boussac, Antonio Díaz Quintana, J.-B. Brubach, Catherine Berthomieu, Rainer Hienerwadel, Lidia Zuccarello, Universidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Molecular, Institut de Biosciences et Biotechnologies d'Aix-Marseille (ex-IBEB) (BIAM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Interactions Protéine Métal (IPM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Luminy Génétique et Biophysique des Plantes (LGBP), Institut de Biologie et de Technologies de Saclay (IBITECS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Ligne AILES, Synchrotron SOLEIL, Synchrotron SOLEIL (SSOLEIL), Centre National de la Recherche Scientifique (CNRS), Instituto de Investigaciones Químicas (IIQ), Universidad de Sevilla / University of Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Photosystème II (PS2), Département Biochimie, Biophysique et Biologie Structurale (B3S), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), and Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)
Subjects: 0301 basic medicine, 030102 biochemistry & molecular biology, Cytochrome, biology, Ligand, Chemistry, Stereochemistry, [SDV]Life Sciences [q-bio], Infrared spectroscopy, Protonation, Electron transport chain, 3. Good health, 03 medical and health sciences, 030104 developmental biology, Ultraviolet visible spectroscopy, biology.protein, [SDV.BV]Life Sciences [q-bio]/Vegetal Biology, General Materials Science, Reactivity (chemistry), Physical and Theoretical Chemistry, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], ComputingMilieux_MISCELLANEOUS, Cysteine
Abstract: His/Cys coordination was recently found in several c-type cytochromes, which could act as sensors, in electron transport or in regulation. Toward a better understanding of Cys function and reactivity in these cytochromes, we compare cytochrome c6 (c6wt) from the cyanobacterium Nostoc PCC 7120 with its Met58Cys mutant. We probe the axial ligands and heme properties by combining visible and mid- to far-FTIR difference spectroscopies. Cys58 determines the strong negative redox potential and pH dependence of M58C (EmM58C = -375 mV, versus Emc6wt = +339 mV). Mid-IR (notably Cys ν(SH), His ν(C5N1), heme (CmH)) and far-IR (ν(Fe(II)-His), ν(His-Fe(III)-Cys)) markers of the heme and ligands show that Cys58 remains a strong thiolate ligand of reduced Met58Cys at alkaline pH, while it is protonated at pH 7.5, is stabilized by a strong hydrogen bonding interaction, and weakly interacts with Fe(II). These data provide a benchmark for further analysis of c-type cytochromes with natural His/Cys coordination French Agence Nationale de la Recherche (ANR) PSIIFIR ANR-15-CE05-0016 French Infrastructure for Integrated Structural Biology (FRISBI) ANR-10-INBS-05 Ministerio de Ciencia e Innovación PGC2018-096049-B-I00 Junta de Andalucía BIO-198, US-1257019, US-1254317
Published: 2020

14. Technological evolution of ceramic glazes in the renaissance: In situ analysis of tiles in the Alcazar (Seville, Spain)

Author: M.D. Robador, Anne Bouquillon, Philippe Walter, Jacques Castaing, Laurence de Viguerie, Jose Luis Perez-Rodriguez, Laboratoire d'Archéologie Moléculaire et Structurale (LAMS), Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Universidad de Sevilla, Instituto de Ciencia de Materiales de Sevilla (ICMSE), Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Centre de recherche et de restauration des musées de France (C2RMF), Centre National de la Recherche Scientifique (CNRS)-Ministère de la Culture et de la Communication (MCC), Institut de Recherche de Chimie Paris (IRCP), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Ministère de la Culture (MC)
Subjects: Engineering, 060102 archaeology, business.industry, The Renaissance, Technological evolution, [CHIM.MATE]Chemical Sciences/Material chemistry, 06 humanities and the arts, 02 engineering and technology, 021001 nanoscience & nanotechnology, Archaeology, visual_art, In situ analysis, Materials Chemistry, Ceramics and Composites, visual_art.visual_art_medium, 0601 history and archaeology, Ceramic, 0210 nano-technology, business
Abstract: International audience; The Alcazar Palace (Seville, Spain) is famous for its ceramic decorations; 16 th century wall tiles of different typologies have been analyzed in order to relate the manufacturing process of their colored glazes to the evolving technologies of the Renaissance. Chemical and mineralogical compositions have been determined in situ by non-destructive X-ray fluorescence (XRF) and X-ray diffraction (XRD) on arista ceramics in the Cenador de Carlos Quinto, and majolica ceramics in the Palacio Gotico and the Royal oratory. The arista style belongs to the local Hispano-Moresque ceramic tradition. Majolica tiles have the complex microstructures of glazes from Italy. The two types are clearly differentiated by their typology, morphology (curved vs flat surface), and also microstructure (single vs multi-layers), glaze chemistry, and use of different coloring agents. Moreover, we found different glaze chemistries in the investigated majolicas, which correspond to different artists and/or practices.
Published: 2018

15. Encapsulation of Upconversion Nanoparticles in Periodic Mesoporous Organosilicas

Author: Clarence Charnay, Christophe Nguyen, Dina Aggad, Manuel Ocaña, Magali Gary-Bobo, Rachid Mahiou, Lamiaa M. A. Ali, Erwan Oliveiro, Damien Boyer, Ana Isabel Becerro Nieto, Jean-Olivier Durand, Laurence Raehm, Nadège Francolon, Daniel González-Mancebo, Chiara Mauriello Jimenez, Saher Rahmani, Institut de Chimie de Clermont-Ferrand - Clermont Auvergne (ICCF), Sigma CLERMONT (Sigma CLERMONT)-Université Clermont Auvergne (UCA)-Centre National de la Recherche Scientifique (CNRS), Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Instituto de Ciencia de Materiales de Sevilla (ICMSE), Universidad de Sevilla / University of Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Institut de Chimie de Clermont-Ferrand (ICCF), SIGMA Clermont (SIGMA Clermont)-Institut de Chimie du CNRS (INC)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Agencia Estatal de Investigación (España), Agence Nationale de la Recherche (France), Ministerio de Ciencia, Innovación y Universidades (España), European Commission, Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), and Clot, Eric
Subjects: Materials science, Condensation polymer, Pharmaceutical Science, Nanoparticle, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Article, Analytical Chemistry, lcsh:QD241-441, Fluorides, Drug Delivery Systems, lcsh:Organic chemistry, TheoryofComputation_ANALYSISOFALGORITHMSANDPROBLEMCOMPLEXITY, [CHIM] Chemical Sciences, Drug Discovery, Technology, Pharmaceutical, cancer, [CHIM]Chemical Sciences, Organosilicon Compounds, Yttrium, Physical and Theoretical Chemistry, Ytterbium, ComputingMilieux_MISCELLANEOUS, Cancer, upconversion, Ethane, Nanotubes, Hydrolysis, Organic Chemistry, periodic mesoporous organosilica nanoparticles, 021001 nanoscience & nanotechnology, Photon upconversion, 0104 chemical sciences, Mesoporous organosilica, Nanomedicine, Chemical engineering, Chemistry (miscellaneous), Drug delivery, Molecular Medicine, Nanoparticles, Nanorod, Periodic mesoporous organosilica nanoparticles, 0210 nano-technology, Mesoporous material, Upconversion, Erbium
Abstract: 1) Background: Nanomedicine has recently emerged as a promising field, particularly for cancer theranostics. In this context, nanoparticles designed for imaging and therapeutic applications are of interest. We, therefore, studied the encapsulation of upconverting nanoparticles in mesoporous organosilica nanoparticles. Indeed, mesoporous organosilica nanoparticles have been shown to be very efficient for drug delivery, and upconverting nanoparticles are interesting for near-infrared and X-ray computed tomography imaging, depending on the matrix used. (2) Methods: Two different upconverting-based nanoparticles were synthesized with Yb3+-Er3+ as the upconverting system and NaYF4 or BaLuF5 as the matrix. The encapsulation of these nanoparticles was studied through the sol-gel procedure with bis(triethoxysilyl)ethylene and bis(triethoxysilyl)ethane in the presence of CTAB. (3) Results: with bis(triethoxysilyl)ethylene, BaLuF5: Yb3+-Er3+, nanoparticles were not encapsulated, but anchored on the surface of the obtained mesoporous nanorods BaLuF5: Yb3+-Er3+@Ethylene. With bis(triethoxysilyl)ethane, BaLuF5: Yb3+-Er3+ and NaYF4: Yb3+-Er3+nanoparticles were encapsulated in the mesoporous cubic structure leading to BaLuF5: Yb3+-Er3+@Ethane and NaYF4: Yb3+-Er3+@Ethane, respectively. (4) Conclusions: upconversion nanoparticles were located on the surface of mesoporous nanorods obtained by hydrolysis polycondensation of bis(triethoxysilyl)ethylene, whereas encapsulation occurred with bis(triethoxysilyl)ethane. The later nanoparticles NaYF4: Yb3+-Er3+@Ethane or BaLuF5: Yb3+-Er3+@Ethane were promising for applications with cancer cell imaging or X-ray-computed tomography respectively., This research was funded by ANR NanoptPDT. SR thanks the Erasmus Mundus program for a grant. This work has been supported by the Spanish Ministry of Science, Innovation and Universities (RTI2018-094426-B-I00).
Published: 2019

16. Catalyst‐Free Synthesis of Alkylpolyglycosides Induced by High‐Frequency Ultrasound

Author: Yves Blériot, José M. García Fernández, Carmen Ortiz Mellet, Jean-Louis Clément, Prince Nana Amaniampong, Karine De Oliveira Vigier, François Jérôme, Gregory Chatel, Didier Gigmes, Centre National de la Recherche Scientifique (France), Université de Poitiers, Junta de Andalucía, European Commission, Conseil régional d'Aquitaine, Institut de Chimie des Milieux et Matériaux de Poitiers (IC2MP), Université de Poitiers-Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Fédération de recherche INCREASE (INCREASE), Institut des Sciences Moléculaires (ISM), Université Montesquieu - Bordeaux 4-Université Sciences et Technologies - Bordeaux 1-École Nationale Supérieure de Chimie et de Physique de Bordeaux (ENSCPB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Montesquieu - Bordeaux 4-Université Sciences et Technologies - Bordeaux 1-École Nationale Supérieure de Chimie et de Physique de Bordeaux (ENSCPB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Centre de Recherche sur l'Intégration Economique et Financière (CRIEF), Université de Poitiers-Université de Poitiers-LIttoral ENvironnement et Sociétés - UMRi 7266 (LIENSs), Université de La Rochelle (ULR)-Centre National de la Recherche Scientifique (CNRS)-Université de La Rochelle (ULR)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie des Milieux et Matériaux de Poitiers (IC2MP), Université de Poitiers-Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Poitiers-Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut des Sciences Chimiques de Rennes (ISCR), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Laboratoire de Chimie des Polymères Organiques (LCPO), Centre National de la Recherche Scientifique (CNRS)-Institut Polytechnique de Bordeaux-Ecole Nationale Supérieure de Chimie, de Biologie et de Physique (ENSCBP)-Université de Bordeaux (UB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut Polytechnique de Bordeaux-Ecole Nationale Supérieure de Chimie, de Biologie et de Physique (ENSCBP)-Université de Bordeaux (UB)-Laboratoire de Génie Chimique (LGC), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Unité de recherche sur les Biopolymères, Interactions Assemblages (BIA), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut de Chimie Radicalaire (ICR), Aix Marseille Université (AMU)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Instituto de Investigaciones Químicas (IIQ), Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Laboratoire de Chimie Moléculaire et Environnement (LCME), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Université Montesquieu - Bordeaux 4-Université Sciences et Technologies - Bordeaux 1 (UB)-École Nationale Supérieure de Chimie et de Physique de Bordeaux (ENSCPB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Montesquieu - Bordeaux 4-Université Sciences et Technologies - Bordeaux 1 (UB)-École Nationale Supérieure de Chimie et de Physique de Bordeaux (ENSCPB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-LIttoral ENvironnement et Sociétés (LIENSs), La Rochelle Université (ULR)-Centre National de la Recherche Scientifique (CNRS)-La Rochelle Université (ULR)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie des Milieux et Matériaux de Poitiers (IC2MP), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire de Chimie des Polymères Organiques (LCPO), Université de Bordeaux (UB)-Ecole Nationale Supérieure de Chimie, de Biologie et de Physique (ENSCBP)-Institut Polytechnique de Bordeaux-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB)-Ecole Nationale Supérieure de Chimie, de Biologie et de Physique (ENSCBP)-Institut Polytechnique de Bordeaux-Centre National de la Recherche Scientifique (CNRS)-Laboratoire de Génie Chimique (LGC), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Unité de recherche sur les Biopolymères, Interactions Assemblages (BIA), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre de recherche sur l'intégration économique et financière (CRIEF), Université de Poitiers-Université de Poitiers, Universidad de Sevilla / University of Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), INCREASE, Region Nouvelle Aquitaine, and ANR-16-CE07-0003,CELLOPLASM,Clivage de la liaison béta-1,4 glycosidique de la cellulose par plasma atmospherique non-thermique: mécanisme et application pour la production d'alkylglycosides(2016)
Subjects: Glycosylation, Surfactants, General Chemical Engineering, Carbohydrates, Degree of polymerization, 010402 general chemistry, 01 natural sciences, Catalysis, symbols.namesake, chemistry.chemical_compound, Ultrasound, [CHIM]Chemical Sciences, Environmental Chemistry, General Materials Science, ComputingMilieux_MISCELLANEOUS, Alkyl, chemistry.chemical_classification, 010405 organic chemistry, Chemistry, Glycoside, Combinatorial chemistry, 3. Good health, 0104 chemical sciences, General Energy, Alkylpolyglycosides, symbols, Degradation (geology), Fischer glycosidation, High frequency ultrasound
Abstract: The irradiation of concentrated feeds of carbohydrates in alcoholic solution by high-frequency ultrasound (550 kHz) induces the formation of alkylpolyglycosides (APGs). This work is distinct from previous reports in that it does not involve any (bio)catalyst or activating agent, it takes place at only 40 °C, thus avoiding degradation of carbohydrates, and it selectively yields APGs with a degree of polymerization in a window of 2¿7, an important limitation of the popular Fischer glycosylation. This ultrasound-based technology proved successful with a range of different valuable carbohydrates and alkyl alcohols. The elucidation of the structure of all the produced glycosides strongly suggests that 1,6-anhydrosugars formed in situ are key intermediate species., Authors are grateful to the CNRS, the University of Poitiers, the Ministry of Research, the Région Nouvelle Aquitaine, the MINECO (contract nos. SAF2016‐76083‐R and CTQ2015‐64425‐C2‐1‐R), the Junta de Andalucía (contract no. FQM2012‐1467) and the European Community (FEDER) for their financial supports.
Published: 2018

17. Local Disorder and Tunable Luminescence in Sr1–x/2Al2–xSixO4 (0.2 ≤ x ≤ 0.5) Transparent Ceramics

Author: Florence Porcher, Wolfgang Wisniewski, Kholoud Al Saghir, Ana I. Becerro, Mathieu Allix, Emmanuel Véron, Guy Matzen, Alberto J. Fernández-Carrión, Franck Fayon, Conditions Extrêmes et Matériaux : Haute Température et Irradiation (CEMHTI), Université d'Orléans (UO)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Instituto de Ciencia de Materiales de Sevilla (ICMSE), Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Laboratoire Léon Brillouin (LLB - UMR 12), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Saclay, Otto-Schott-Institut für Glaschemie, Friedrich-Schiller-Universität = Friedrich Schiller University Jena [Jena, Germany], ANR-11-EQPX-0036,PLANEX,Planète Expérimentation: simulation et analyse in-situ en conditions extrêmes(2011), ANR-14-CE07-0002,FOCAL,Fibres Optiques Céramiques pour Applications Lasers(2014), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université d'Orléans (UO), Universidad de Sevilla / University of Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Junta de Andalucía, Agence Nationale de la Recherche (France), Ministerio de Economía y Competitividad (España), and Department of Energy (US)
Subjects: Transparent ceramics, Chemistry, Doping, chemistry.chemical_element, [CHIM.MATE]Chemical Sciences/Material chemistry, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, 0104 chemical sciences, Aerodynamic levitation, law.invention, Inorganic Chemistry, Crystallography, law, Light emission, Physical and Theoretical Chemistry, Crystallization, 0210 nano-technology, Europium, Luminescence, Superstructure (condensed matter)
Abstract: Eu-doped SrAlSiO (x = 0.2, 0.4, and 0.5) transparent ceramics have been synthesized by full and congruent crystallization from glasses prepared by aerodynamic levitation and laser-heating method. Structural refinements from synchrotron and neutron powder diffraction data show that the ceramics adopt a 1 × 1 × 2 superstructure compared to the SrAlO hexagonal polymorph. While the observed superstructure reflections indicate a long-range ordering of the Sr vacancies in the structure, Si and Al solid-state NMR measurements associated with DFT computations reveal a significant degree of disorder in the fully polymerized tetrahedral network. This is evidenced through the presence of Si-O-Si bonds, as well as Si(OAl) units at remote distances of the Sr vacancies and Al(OAl) units in the close vicinity of Sr vacancies departing from local charge compensation in the network. The transparent ceramics can be doped by europium to induce light emission arising from the volume under UV excitation. Luminescence measurements then reveal the coexistence of Eu and Eu in the samples, thereby allowing tuning the emission color depending on the excitation wavelength and suggesting possible applications such as solid state lighting., The authors also thank the French ANR for its financial support to the FOCAL ANR-14-CE07-0002 and Equipex Planex ANR-11-EQPX-36 projects, the CNRS and CSIC for the PICS n° 07490 and PIC2016FR1 projects, as well as the Spanish Ministry of Economy and Competitiveness for the grant MAT2014 54852-R. A. J. F.-C. gratefully acknowledges an F. P. D. I. grant from Junta de Andalucía. Financial support from the TGIR RMN THC FR3050 for conducting the research is gratefully acknowledged. Use of the Advanced Photon Source at Argonne National Laboratory was supported by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences, under Contract No. DE-AC02-06CH11357.
Published: 2017

18. SUMOylation regulates LKB1 localization and its oncogenic activity in liver cancer

Author: Imanol Zubiete-Franco, Virginia Gutiérrez-de-Juan, Matías A. Avila, José M. Mato, Marta Varela-Rey, Diego F. Calvisi, Manuel S. Rodriguez, Teresa C. Delgado, Patricia Aspichueta, Juan L. García-Rodríguez, Onintza Carlevaris, Naiara Beraza, Marina Serrano-Macia, Sergio López de Davalillo, María L. Martínez-Chantar, David Fernández-Ramos, César Martín, Irene Díaz-Moreno, Fernando Lopitz-Otsoa, Pablo Fernández-Tussy, Edurne Berra, Adolfo Beguiristain Gomez, Lucía Barbier-Torres, Jorge Simón, Erica Villa, Antonio Díaz-Quintana, Centro de Investigación Biomédica en Red en el Área temática de Enfermedades Hepáticas y Digestivas (CIBERehd), Liver Unit, Clínica Universitaria, CIBER-EHD, Institut de signalisation, biologie du développement et cancer (ISBDC), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA), Institut de pharmacologie et de biologie structurale (IPBS), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Institut des Technologies Avancées en sciences du Vivant (ITAV), Instituto de Investigaciones Químicas (IIQ), Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), and Universidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Molecular
Subjects: 0301 basic medicine, Models, Molecular, Genetics and Molecular Biology (all), AMPK, Research paper, Protein Conformation, hepatocellular-carcinoma, molecular-dynamics, SUMO protein, activated protein-kinase, SUMO binding, Biochemistry, tumor-suppressor lkb1, Mice, 0302 clinical medicine, AMP-Activated Protein Kinase Kinases, STRADalpha, HCC, Hypoxia, skin and connective tissue diseases, Cellular localization, Oncogene Proteins, LKB1, SIRT1, STRADα, SUMO, Biochemistry, Genetics and Molecular Biology (all), phosphorylation, Liver Neoplasms, Acetylation, General Medicine, glycine n-methyltransferase, Protein Transport, 030220 oncology & carcinogenesis, Nucleocytoplasmic Shuttling, Heterografts, C-ZETA, Liver cancer, Hepatoma cell, Hypoxic stress, Protein Binding, congenital, hereditary, and neonatal diseases and abnormalities, Carcinoma, Hepatocellular, Cell Survival, [SDV.CAN]Life Sciences [q-bio]/Cancer, Biology, Protein Serine-Threonine Kinases, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Structure-Activity Relationship, Stress, Physiological, Cell Line, Tumor, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], medicine, Animals, Humans, hypoxia-inducible factor, SUMO conjugation, Cancer, Sumoylation, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, medicine.disease, Disease Models, Animal, 030104 developmental biology, Cancer research
Abstract: Background Even though liver kinase B1 (LKB1) is usually described as a tumor suppressor in a wide variety of tissues, it has been shown that LKB1 aberrant expression is associated with bad prognosis in Hepatocellular Carcinoma (HCC). Methods Herein we have overexpressed LKB1 in human hepatoma cells and by using histidine pull-down assay we have investigated the role of the hypoxia-related post-translational modification of Small Ubiquitin-related Modifier (SUMO)ylation in the regulation of LKB1 oncogenic role. Molecular modelling between LKB1 and its interactors, involved in regulation of LKB1 nucleocytoplasmic shuttling and LKB1 activity, was performed. Finally, high affinity SUMO binding entities-based technology were used to validate our findings in a pre-clinical mouse model and in clinical HCC. Findings We found that in human hepatoma cells under hypoxic stress, LKB1 overexpression increases cell viability and aggressiveness in association with changes in LKB1 cellular localization. Moreover, by using site-directed mutagenesis, we have shown that LKB1 is SUMOylated by SUMO-2 at Lys178 hampering LKB1 nucleocytoplasmic shuttling and fueling hepatoma cell growth. Molecular modelling of SUMO modified LKB1 further confirmed steric impedance between SUMOylated LKB1 and the STe20-Related ADaptor cofactor (STRADα), involved in LKB1 export from the nucleus. Finally, we provide evidence that endogenous LKB1 is modified by SUMO in pre-clinical mouse models of HCC and clinical HCC, where LKB1 SUMOylation is higher in fast growing tumors. Interpretation Overall, SUMO-2 modification of LKB1 at Lys178 mediates LKB1 cellular localization and its oncogenic role in liver cancer. Fund This work was supported by grants from NIH (US Department of Health and Human services)-R01AR001576-11A1 (J.M.M and M.L.M-C.), Gobierno Vasco-Departamento de Salud 2013111114 (to M.L.M.-C), ELKARTEK 2016, Departamento de Industria del Gobierno Vasco (to M.L.M.-C), MINECO: SAF2017–87301-R and SAF2014–52097-R integrado en el Plan Estatal de Investigación Cientifica y Técnica y Innovación 2013–2016 cofinanciado con Fondos FEDER (to M.L.M.-C and J.M.M., respectively), BFU2015–71017/BMC MINECO/FEDER, EU (to A.D.Q. and I.D.M.), BIOEF (Basque Foundation for Innovation and Health Research): EITB Maratoia BIO15/CA/014; Instituto de Salud Carlos III:PIE14/00031, integrado en el Plan Estatal de Investigación Cientifica y Técnica y Innovacion 2013–2016 cofinanciado con Fondos FEDER (to M.L.M.-C and J.M.M), Asociación Española contra el Cáncer (T.C.D, P·F-T and M.L.M-C), Daniel Alagille award from EASL (to T.C.D), Fundación Científica de la Asociación Española Contra el Cancer (AECC Scientific Foundation) Rare Tumor Calls 2017 (to M.L.M and M.A), La Caixa Foundation Program (to M.L.M), Programma di Ricerca Regione-Università 2007–2009 and 2011–2012, Regione Emilia-Romagna (to E.V.), Ramón Areces Foundation and the Andalusian Government (BIO-198) (A.D.Q. and I.D.M.), ayudas para apoyar grupos de investigación del sistema Universitario Vasco IT971–16 (P.A.), MINECO:SAF2015–64352-R (P.A.), Institut National du Cancer, FRANCE, INCa grant PLBIO16–251 (M.S.R.), MINECO - BFU2016–76872-R to (E.B.). Work produced with the support of a 2017 Leonardo Grant for Researchers and Cultural Creators, BBVA Foundation (M.V-R). Finally, Ciberehd_ISCIII_MINECO is funded by the Instituto de Salud Carlos III. We thank MINECO for the Severo Ochoa Excellence Accreditation to CIC bioGUNE (SEV-2016-0644). Funding sources had no involvement in study design; in the collection, analysis, and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication., Highlights • Overexpression of LKB1 in human hepatoma cells during hypoxic stress induces deregulated cell growth and survival. • SUMO-2 modifications of LKB1 at Lys178 occur in human hepatoma cells hampering its nucleocytoplasmic shuttling. • LKB1 SUMOylation is augmented in pre-clinical mouse models and clinical HCC, being a hallmark of more aggressive HCC tumors.
Published: 2019

19. Multivalent glycoligands with lectin/enzyme dual specificity: self-deliverable glycosidase regulators

Author: David Goyard, Eiji Nanba, Olivier Renaudet, Katsumi Higaki, Carmen Ortiz Mellet, Manuel González-Cuesta, José M. García Fernández, Universidad de Sevilla, Département de Chimie Moléculaire (DCM), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Tottori University, Instituto de Investigaciones Químicas (IIQ), Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Département de Chimie Moléculaire - Ingéniérie et Intéractions BioMoléculaires (DCM - I2BM), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), European Commission, Junta de Andalucía, Université Grenoble Alpes, Japan Society for the Promotion of Science, Centre National de la Recherche Scientifique (France), European Research Council, Agencia Estatal de Investigación (España), Consejo Superior de Investigaciones Científicas (España), González-Cuesta, Manuel [0000-0003-2778-9489], Goyard, David [0000-0002-6410-0866], García-Fernández, José M. [0000-0002-6287-0387], Renaudet, Olivier [0000-0003-4963-3848], Ortíz-Mellet, Carmen [0000-0002-7676-7721], Universidad de Sevilla. Departamento de Química orgánica, González-Cuesta, Manuel, Goyard, David, García-Fernández, José M., Renaudet, Olivier, and Ortíz-Mellet, Carmen
Subjects: Mannosides, Peptide, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, Selective inhibition, 010402 general chemistry, 01 natural sciences, Peptides, Cyclic, Catalysis, alpha-Mannosidase, Dendrimer, Lectins, Materials Chemistry, Glycoside hydrolase, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], chemistry.chemical_classification, biology, [CHIM.ORGA]Chemical Sciences/Organic chemistry, 010405 organic chemistry, Macrophages, beta-Cyclodextrins, Metals and Alloys, Lectin, General Chemistry, Raft, 0104 chemical sciences, 3. Good health, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Enzyme, chemistry, Biochemistry, Drug Design, Ceramics and Composites, biology.protein, Glucosylceramidase
Abstract: Multivalentmannosideswith inherentmacrophage recognition abilities, built on b-cyclodextrin, RAFT cyclopeptide or peptide dendrimer cores, trigger selective inhibition of lysosomal b-glucocerebrosidase or a-mannosidase depending on valency and topology, offering new opportunities in multitargeted drug design, The authors thank MINECO and MCIU/AEI (SAF2016-76083-R and RTI2018-097609-B-C21), the Junta de Andalucía (FQM2012-1467), the European Regional Development Funds (FEDER and FSE, UE), CNRS, Université Grenoble Alpes, ICMG FR 2607, the French ANR project Glyco@Alps (ANR-15-IDEX-02), Labex ARCANE, CBH-EUR-GS (ANR-17-EURE-0003), the COST action GLYCONanoPROBES (CM18132) and the JSPS KAKENHI Grant 17K10051 for financial support. We acknowledge the CSIC (URICI) for supporting open access publication and the CITIUS (Univ. Seville) for technical support. O. R. acknowledges the European Research Council Consolidator Grant “LEGO” (647938) for D. G. M. G.-C. is a FPI fellow
Published: 2019

20. CO/H 2 adsorption on a Ru/Al 2 O 3 model catalyst for Fischer Trospch: Effect of water concentration on the surface species

Author: Carlos López-Cartes, E.M. Jimenez-Barrera, José Antonio Odriozola, Francisca Romero-Sarria, Marco Daturi, Philippe Bazin, Instituto de Ciencia de Materiales de Sevilla (ICMSE), Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Laboratoire catalyse et spectrochimie (LCS), Centre National de la Recherche Scientifique (CNRS)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Normandie Université (NU)-Institut de Chimie du CNRS (INC)-Université de Caen Normandie (UNICAEN), Normandie Université (NU), Universidad de Sevilla, and Ministerio de Economía y Competitividad (España)
Subjects: Inorganic chemistry, Infrared spectroscopy, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Catalysis, Dissociation (chemistry), Surface species, Ruthenium, Metal, Adsorption, Monolayer, [CHIM]Chemical Sciences, General Environmental Science, Chemistry, Process Chemistry and Technology, Tropsch, Fischer–Tropsch process, Fischer Tropsch, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Fischer, 13. Climate action, visual_art, visual_art.visual_art_medium, Water effect, 0210 nano-technology, Selectivity
Abstract: Water presence and concentration strongly influence CO conversion and C selectivity in the Fischer Tropsch reaction. In this work, the influence of the water concentration was investigated using a model Ru/AlO (5 wt.%) catalyst. The surface species formed after CO and H adsorption in dry and wet (different water concentrations) conditions were analyzed by FTIR. Firstly, water adsorption was carried out up to complete filling of the pores and then CO was put in contact with the catalyst. The absence of adsorbed CO species in these conditions evidences that CO diffusion in water controls the access of the gas to the active sites and explains the negative effect of high water concentrations reported by some authors. Moreover, the adsorption of a mixture of CO+H+HO, being the water concentration close to that needed to have a monolayer, and a dry mixture of CO+H were carried out and compared. Results evidence that water in this low concentration, is able to gasify the surface carbon species formed by CO dissociation on the metallic sites. This cleaning effect is related to the positive effect of water on CO conversion detected by some authors., The authors gratefully acknowledge the financial support from the Spanish Ministerio de Economía y Competitividad –MINECO (ENE2015-66975-C3-2R).
Published: 2018

21. Metal films by Laser Ablation Backwriting on Glass

Author: Angurela, L. A., Molina, R., Rico, V., Yubero, F., González-Elipe, A. R., Muñoz-Rojas, David, Nguyen, V., Masse de la Huerta, César, Fuente, G. F. de la, Institut Supérieur de l'Aéronautique et de l'Espace (ISAE-SUPAERO), Instituto de Ciencia de Materiales de Sevilla (ICMSE), Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Laboratoire des matériaux et du génie physique (LMGP ), and Institut National Polytechnique de Grenoble (INPG)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Subjects: [CHIM.MATE]Chemical Sciences/Material chemistry, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2018

22. Fundamental aspects about the first steps of irradiation-induced phase transformations in fluorite-related oxides

Author: F. Paumier, Bertrand Lacroix, R.J. Gaboriaud, Instituto de Ciencia de Materiales de Sevilla (ICMSE), Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Physique et Propriétés des Nanostructures PPNa (PPNa), Département Physique et Mécanique des Matériaux (Département Physique et Mécanique des Matériaux), Institut Pprime (PPRIME), Université de Poitiers-ENSMA-Centre National de la Recherche Scientifique (CNRS)-Université de Poitiers-ENSMA-Centre National de la Recherche Scientifique (CNRS)-Institut Pprime (PPRIME), and Université de Poitiers-ENSMA-Centre National de la Recherche Scientifique (CNRS)-Université de Poitiers-ENSMA-Centre National de la Recherche Scientifique (CNRS)
Subjects: Phase transition, Materials science, Polymers and Plastics, Lattice defects, [PHYS.MPHY]Physics [physics]/Mathematical Physics [math-ph], Nucleation, 02 engineering and technology, 01 natural sciences, [SPI.AUTO]Engineering Sciences [physics]/Automatic, Residual stresses, Lattice constant, [PHYS.QPHY]Physics [physics]/Quantum Physics [quant-ph], Phase (matter), 0103 physical sciences, [PHYS.MECA.MEFL]Physics [physics]/Mechanics [physics]/Fluid mechanics [physics.class-ph], [PHYS.MECA.BIOM]Physics [physics]/Mechanics [physics]/Biomechanics [physics.med-ph], 010306 general physics, [SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], [PHYS.MECA.VIBR]Physics [physics]/Mechanics [physics]/Vibrations [physics.class-ph], Condensed matter physics, [SPI.FLUID]Engineering Sciences [physics]/Reactive fluid environment, [SPI.NRJ]Engineering Sciences [physics]/Electric power, Metals and Alloys, [CHIM.MATE]Chemical Sciences/Material chemistry, [PHYS.MECA.MSMECA]Physics [physics]/Mechanics [physics]/Materials and structures in mechanics [physics.class-ph], 021001 nanoscience & nanotechnology, Crystalline oxides, Crystallographic defect, Electronic, Optical and Magnetic Materials, Amorphous solid, Nucleation of phase transformations, [PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], [SPI.ELEC]Engineering Sciences [physics]/Electromagnetism, [CHIM.POLY]Chemical Sciences/Polymers, Ion irradiation, Ceramics and Composites, [PHYS.MECA.THER]Physics [physics]/Mechanics [physics]/Thermics [physics.class-ph], Dislocation, 0210 nano-technology, Monoclinic crystal system
Abstract: Fundamental aspects of ion-irradiation-induced phase transformations in fluorite-related oxides, from cubic to monoclinic structures, are investigated through xenon implantation at medium energy in yttrium sesquioxide (Y2O3). For that purpose, an original approach considering this material fabricated as a thin film is proposed to control the pristine structure before irradiation and to allow fine measurements of internal stresses. It is evidenced that this oxide can be strongly disordered up to an unexpected amorphization, depending on the initial damage state. We emphasize that point defects created during the irradiation process generate strong internal stresses which turn out to be a major parameter in the mechanism involved during such phase transition. When the oxide structure is initially weakly disordered, the evolutions of the biaxial and triaxial residual stresses, together with the lattice parameter, presents two different steps. Those steps are interpreted at the atomic scale by the nucleation of oxygen vacancy aggregates which collapse in extended dislocation loops that are considered as monoclinic nuclei. The geometry of these extended defects has been considered to explain why the monoclinic phase appears with clearly defined crystallographic orientation relationship (4 0 2 ¯ )B//(2 2 2)C relative to the initial cubic phase. The link between the energy deposited by irradiation and the critical size of these defects, analyzed from a thermodynamical approach by the evaluation of the Gibbs free energy, also elucidates the presence of sharp thresholds observed between the different phases (amorphous/cubic and monoclinic/amorphous) along the depth of the film.
Published: 2018

23. High ultrasonic frequencies for selective oxidation of sugars: new investigations and insights

Author: Chatel, Gregory, Amaniampong, Prince, Karam, Ayman, Ortiz Mellet, Carmen, Garcia Fernandez, José, Blériot, Yves, de Oliveira Vigier, Karine, Jérôme, François, Laboratoire de Chimie Moléculaire et Environnement (LCME), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Institut de Chimie des Milieux et Matériaux de Poitiers (IC2MP), Université de Poitiers-Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Fédération de recherche INCREASE (INCREASE), Institut des Sciences Moléculaires (ISM), Université Montesquieu - Bordeaux 4-Université Sciences et Technologies - Bordeaux 1-École Nationale Supérieure de Chimie et de Physique de Bordeaux (ENSCPB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Montesquieu - Bordeaux 4-Université Sciences et Technologies - Bordeaux 1-École Nationale Supérieure de Chimie et de Physique de Bordeaux (ENSCPB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Centre de Recherche sur l'Intégration Economique et Financière (CRIEF), Université de Poitiers-Université de Poitiers-LIttoral ENvironnement et Sociétés - UMRi 7266 (LIENSs), Université de La Rochelle (ULR)-Centre National de la Recherche Scientifique (CNRS)-Université de La Rochelle (ULR)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie des Milieux et Matériaux de Poitiers (IC2MP), Université de Poitiers-Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Poitiers-Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut des Sciences Chimiques de Rennes (ISCR), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Laboratoire de Chimie des Polymères Organiques (LCPO), Centre National de la Recherche Scientifique (CNRS)-Institut Polytechnique de Bordeaux-Ecole Nationale Supérieure de Chimie, de Biologie et de Physique (ENSCBP)-Université de Bordeaux (UB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut Polytechnique de Bordeaux-Ecole Nationale Supérieure de Chimie, de Biologie et de Physique (ENSCBP)-Université de Bordeaux (UB)-Laboratoire de Génie Chimique (LGC), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Unité de recherche sur les Biopolymères, Interactions Assemblages (BIA), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Instituto de Investigaciones Químicas (IIQ), Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Université Montesquieu - Bordeaux 4-Université Sciences et Technologies - Bordeaux 1 (UB)-École Nationale Supérieure de Chimie et de Physique de Bordeaux (ENSCPB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Montesquieu - Bordeaux 4-Université Sciences et Technologies - Bordeaux 1 (UB)-École Nationale Supérieure de Chimie et de Physique de Bordeaux (ENSCPB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-LIttoral ENvironnement et Sociétés (LIENSs), La Rochelle Université (ULR)-Centre National de la Recherche Scientifique (CNRS)-La Rochelle Université (ULR)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie des Milieux et Matériaux de Poitiers (IC2MP), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire de Chimie des Polymères Organiques (LCPO), Université de Bordeaux (UB)-Ecole Nationale Supérieure de Chimie, de Biologie et de Physique (ENSCBP)-Institut Polytechnique de Bordeaux-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB)-Ecole Nationale Supérieure de Chimie, de Biologie et de Physique (ENSCBP)-Institut Polytechnique de Bordeaux-Centre National de la Recherche Scientifique (CNRS)-Laboratoire de Génie Chimique (LGC), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Unité de recherche sur les Biopolymères, Interactions Assemblages (BIA), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre de recherche sur l'intégration économique et financière (CRIEF), Université de Poitiers-Université de Poitiers, and Universidad de Sevilla / University of Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)
Subjects: [CHIM.ORGA]Chemical Sciences/Organic chemistry, [CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2018

24. Revealing cooperative binding of polycationic cyclodextrins with DNA oligomers by capillary electrophoresis coupled to mass spectrometry

Author: Juan M. Benito, José M. García Fernández, Carmen Ortiz Mellet, Cédric Przybylski, Véronique Bonnet, Ministerio de Economía y Competitividad (España), Chimie Structurale Organique et Biologique (CSOB), Institut Parisien de Chimie Moléculaire (IPCM), Chimie Moléculaire de Paris Centre (FR 2769), Institut de Chimie du CNRS (INC)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Chimie du CNRS (INC)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Chimie Moléculaire de Paris Centre (FR 2769), Université Paris sciences et lettres (PSL)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Instituto de Investigaciones Químicas (IIQ), Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Laboratoire de Glycochimie, des Antimicrobiens et des Agro-ressources - UMR CNRS 7378 (LG2A ), and Université de Picardie Jules Verne (UPJV)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Subjects: POLE 3, Cooperative effects, DNA, Single-Stranded, dnaN, Gene delivery, 010402 general chemistry, Mass spectrometry, 01 natural sciences, Biochemistry, Mass Spectrometry, Polymerization, Analytical Chemistry, chemistry.chemical_compound, Capillary electrophoresis, [CHIM]Chemical Sciences, Environmental Chemistry, Hill number, Spectroscopy, Cyclodextrins, Drug Carriers, Chromatography, Base Sequence, 010405 organic chemistry, Oligonucleotide, Electrophoresis, Capillary, Cooperative binding, DNA, 0104 chemical sciences, Polycationic cyclodextrins, chemistry, CE-MS, Nucleic acid, CSOB
Abstract: Gene delivery is critical for the development of nucleic acid-based therapies against a range of severe diseases. The conception of non-viral (semi)synthetic vectors with low cytotoxicity and virus-like efficiency is gathering a lot of efforts, but it represents a fantastic challenge still far from accomplishment. Carbohydrate-based scaffolds offer interesting features towards this end, such as easy availability, relatively cheap cost, tuning properties and a good biocompatibility. The lack of analytical methods providing quantitative and qualitative data on their binding properties with oligonucleotides (DNA/RNA), with a minimal time and sample consumption, represents a limitation for these channels. Here, we attempted to fill the gap by hyphenation of capillary electrophoresis with mass spectrometry (CE-MS). This coupling strategy allows discriminating free and complexed DNA oligomers with cationic cyclodextrins (CDs), determining the stoichiometry where the highest observed is always DNA: n/3(CD), and unambiguously assigning the partners through m/z detection. Very reliable data were obtained with migration time within 5.5 (standard deviation < 0.5%) and 25 min (standard deviation < 1.1%) for UV and MS detection, respectively. Furthermore, varying the nitrogen/phosphorus ratio (N/P), key parameters relating to the thermodynamics e.g. the micro and macroscopic dissociation constants K and K, respectively (both in low μM range) and the Gibbs free energy ΔG (−16.3 to −26.9 kJ mol), and also the cooperativity as Hill number (nH between 0.98 and 15.75) of the supramolecular process can be delineated, providing a unique tool for the high throughput screening and selection of efficient gene delivery carriers., The authors thank Genopole-France and the Conseil Régional d’Ile-de-France and the Spanish Ministerio de Economia y Competitividad (MinECo, contract no. SAF2013-44021-R and CTQ2015-64425-C2-1-R).
Published: 2018

25. A Roma founder BIN1 mutation causes a novel phenotype of centronuclear myopathy with rigid spine

Author: Eloy Rivas, Juan J. Vílchez, Cristina Domínguez, Nigel G. Laing, Valérie Biancalana, Pablo Quiroga, Montse Olivé, Aurelio Hernández-Lain, Fabiola Mavillard, Macarena Cabrera-Serrano, Eduardo Khan, Luba Kalaydjieva, Nuria Muelas, Carmen Paradas, Jocelyn Laporte, Alejandra Carvajal, Jordi Díaz-Manera, Norma B. Romero, Bharti Morar, Mark M. Davis, David Comas, Rainiero Ávila, Instituto de Biomedicina de Sevilla [Sevilla, Spain] (IBIS/HUVR), Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hospital Universitario Virgen del Rocío [Sevilla], The University of Western Australia (UWA), Health Research Institute [Madrid, Espagne], L’Hospitalet de Llobregat [Barcelona, Spain], CIBER de Enfermedades Raras (CIBERER), Hospital General Universitario Santa Lucía (Cartagena), Hospital Universitario Virgen de las Nieves [Granada, Spain] (HUVN), Universitat Autònoma de Barcelona (UAB), PathWest Laboratory Medicine, Royal Perth Hospital, Institut de Myologie, Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Association française contre les myopathies (AFM-Téléthon)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Immunologie humaine, physiopathologie & immunothérapie (HIPI (UMR_S_976 / U976)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPC), Universitat Pompeu Fabra [Barcelona] (UPF), Universidad de Sevilla / University of Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)
Subjects: Adult, 0301 basic medicine, medicine.medical_specialty, Roma, Neuromuscular disease, Adolescent, Population, Mallory Bodies, Compound heterozygosity, Article, Muscular Dystrophies, Cohort Studies, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, Prospective Studies, Centronuclear myopathy, Child, education, Prospective cohort study, Adaptor Proteins, Signal Transducing, Retrospective Studies, education.field_of_study, business.industry, Tumor Suppressor Proteins, Haplotype, Nuclear Proteins, Retrospective cohort study, Middle Aged, medicine.disease, Founder Effect, Phenotype, 030104 developmental biology, Scoliosis, Spain, Mutation, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Neurology (clinical), business, 030217 neurology & neurosurgery, Myopathies, Structural, Congenital, Founder effect
Abstract: ObjectiveTo describe a large series of BIN1 patients, in which a novel founder mutation in the Roma population of southern Spain has been identified.MethodsPatients diagnosed with centronuclear myopathy (CNM) at 5 major reference centers for neuromuscular disease in Spain (n = 53) were screened for BIN1 mutations. Clinical, histologic, radiologic, and genetic features were analyzed.ResultsEighteen patients from 13 families carried the p.Arg234Cys variant; 16 of them were homozygous for it and 2 had compound heterozygous p.Arg234Cys/p.Arg145Cys mutations. Both BIN1 variants have only been identified in Roma, causing 100% of CNM in this ethnic group in our cohort. The haplotype analysis confirmed all families are related. In addition to clinical features typical of CNM, such as proximal limb weakness and ophthalmoplegia, most patients in our cohort presented with prominent axial weakness, often associated with rigid spine. Severe fat replacement of paravertebral muscles was demonstrated by muscle imaging. This phenotype seems to be specific to the p.Arg234Cys mutation, not reported in other BIN1 mutations. Extreme clinical variability was observed in the 2 compound heterozygous patients for the p.Arg234Cys/p.Arg145Cys mutations, from a congenital onset with catastrophic outcome to a late-onset disease. Screening of European Roma controls (n = 758) for the p.Arg234Cys variant identified a carrier frequency of 3.5% among the Spanish Roma.ConclusionWe have identified a BIN1 founder Roma mutation associated with a highly specific phenotype, which is, from the present cohort, the main cause of CNM in Spain.
Published: 2018

26. Structural, optical and X-ray attenuation properties of Tb3+:BaXCe1-xF3-x (x = 0.18-0.48) nanospheres synthesized in polyol medium

Author: Manuel Ocaña, Mathieu Allix, Ana I. Becerro, Cécile Genevois, Ángel Parrado-Gallego, Daniel González-Mancebo, Ariadna Corral, Instituto de Ciencia de Materiales de Sevilla (ICMSE), Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Conditions Extrêmes et Matériaux : Haute Température et Irradiation (CEMHTI), and Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université d'Orléans (UO)
Subjects: Aqueous solution, Materials science, Analytical chemistry, chemistry.chemical_element, Barium, 02 engineering and technology, [CHIM.MATE]Chemical Sciences/Material chemistry, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, 7. Clean energy, 0104 chemical sciences, 3. Good health, Inorganic Chemistry, Colloid, Cerium, chemistry.chemical_compound, chemistry, Phase (matter), Sodium tetrafluoroborate, 0210 nano-technology, Luminescence, Ethylene glycol, ComputingMilieux_MISCELLANEOUS
Abstract: Uniform BaCeF nanospheres have been obtained after aging a solution of barium and cerium nitrates and sodium tetrafluoroborate in a mixture of ethylene glycol and water at 120 °C for 20 hours. The diameter of the spheres could be tailored from 65 nm to 80 nm by varying the NaBF concentration while maintaining their colloidal stability in aqueous suspension. Increasing the aging temperature led to a phase transformation from hexagonal to cubic symmetry and to a concomitant increase of the Ba/Ce ratio, which reached a value close to the nominal one (50/50) at 240 °C. The same method was successful in obtaining Tb-doped nanospheres with homogeneous cation distribution and the same morphological features as the undoped material. An intense green emission was observed after the excitation of the Tb-doped samples through the Ce-Tb energy transfer (ET) band. The ET efficiency increased with increasing Tb content, the maximum emission being observed for the 10% Tb-doped nanospheres. Aqueous suspensions of the latter sample showed excellent X-ray attenuation values that were superior to those of an iodine-based clinically approved contrast agent. Their fluorescence and X-ray attenuation properties make this material a potential dual bioprobe for luminescence bioimaging and X-ray computed tomography.
Published: 2018

27. Ligand effects on the selective hydrogenation of nitrobenzene to cyclohexylamine using ruthenium nanoparticles as catalysts

Author: Iann C. Gerber, Salvador Conejero, M. Rosa Axet, Centre National de la Recherche Scientifique (France), European Commission, Ministerio de Economía y Competitividad (España), Institut du Développement et des Ressources en Informatique Scientifique (France), Laboratoire de chimie de coordination (LCC), Institut de Chimie de Toulouse (ICT-FR 2599), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut de Recherche pour le Développement (IRD)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées, Instituto de Investigaciones Químicas (IIQ) and Departamento de Química Inorgánica, Consejo Superior de Investigaciones Científicas (CSIC) and Universidad de Sevilla, Laboratoire de physique et chimie des nano-objets (LPCNO), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut de Chimie de Toulouse (ICT-FR 2599), Université Fédérale Toulouse Midi-Pyrénées-Institut de Recherche sur les Systèmes Atomiques et Moléculaires Complexes (IRSAMC), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie de Toulouse (ICT-FR 2599), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Instituto de Investigaciones Químicas (IIQ), Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Institut de Recherche sur les Systèmes Atomiques et Moléculaires Complexes (IRSAMC), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie de Toulouse (ICT-FR 2599), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut de Chimie du CNRS (INC), Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Universidad de Sevilla / University of Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut de Chimie de Toulouse (ICT), Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche sur les Systèmes Atomiques et Moléculaires Complexes (IRSAMC), Université Toulouse III - Paul Sabatier (UT3), and Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)
Subjects: chemistry.chemical_element, Nanoparticle, Cyclohexylamine, 010402 general chemistry, 01 natural sciences, Catalysis, Ruthenium, Nitrobenzene, chemistry.chemical_compound, Polymer chemistry, [CHIM]Chemical Sciences, General Materials Science, [CHIM.COOR]Chemical Sciences/Coordination chemistry, Chemoselectivity, 010405 organic chemistry, Ligand, Hydride, [CHIM.CATA]Chemical Sciences/Catalysis, [CHIM.MATE]Chemical Sciences/Material chemistry, 0104 chemical sciences, Ligand effects, chemistry, Nanoparticles, Hydrogenation
Abstract: A series of ruthenium nanoparticles (Ru NPs) bearing different ligands on their surfaces have been used as catalysts in the selective hydrogenation of nitrobenzene to cyclohexylamine. Ru C60, Ru-PVP, Ru-HDA, and Ru-IPr [PVP = poly(vinylpyrrolidone); HDA = hexadecylamine, IPr = 1,3-bis(2,6- diisopropylphenyl)imidazol-2-ylidene] have been chosen because of their different electronic properties, with HDA and IPr acting as donor ligands, PVP as a polymer with small interaction with the Ru NP surface, and fullerene C60 as an electron-attractor ligand, while their size and structure remain similar. A clear influence of the ligand on the Ru NP surface on the catalytic performances was observed. The less donor ligands promote hydrogenation of the N-phenylhydroxylamine (PHA) intermediate, which is considered to be the rate-determining step, leading to the more active catalysts, affecting also the chemoselectivity of the reaction. Density functional theory (DFT) calculations show that the hydride coverage of the Ru NPs plays a key role in the adsorption of PHA on the surface of the NPs. This adsorption is indeed unfavored for realistic coverage values, higher than 1.5H/per surface Ru atom, explaining the accumulation of this intermediate under hydrogenation conditions, as observed with all Ru NPs here studied. In addition, DFT calculations show that the adsorption of PHA is favored when fullerene C60 is present on the Ru NP surface compared to the uncapped Ru NPs, which correlates well with the higher turnover frequency observed for Ru-C60 catalyst compared to the other Ru NP systems bearing more donating ligands and also the higher selectivity obtained with this catalyst., This work was supported by the CNRS, which we gratefully acknowledge. We are thankful for financial support (FEDER contribution) from the MINECO (Projects CTQ2016-76267-P and CTQ2016-81797-REDC). I.C.G. acknowledges the Calcul en Midi-Pyrénées initiative CALMIP (Project p0812) for allocation of computer time. This work was also granted access to the HPC resources of CINES and IDRIS under the Allocation 2017-A0040906649 made by GENCI.
Published: 2018

28. Xylylene Clips for the Topology-Guided Control of the Inclusion and Self-Assembling Properties of Cyclodextrins

Author: Juan M. Benito, Carmen Ortiz Mellet, Cédric Przybylski, Francisco Mendicuti, Thais Carmona, José M. García Fernández, Tania Neva, University of Sevilla, Universidad de Alcalá - University of Alcalá (UAH), Instituto de Investigaciones Químicas (IIQ), Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Chimie Structurale Organique et Biologique (CSOB), Institut Parisien de Chimie Moléculaire (IPCM), Chimie Moléculaire de Paris Centre (FR 2769), Institut de Chimie du CNRS (INC)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Chimie du CNRS (INC)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Chimie Moléculaire de Paris Centre (FR 2769), Université Paris sciences et lettres (PSL)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), European Commission, Universidad de Alcalá, Junta de Andalucía, Ministerio de Economía y Competitividad (España), and Universidad de Sevilla
Subjects: POLE 3, 010405 organic chemistry, Chemistry, Organic Chemistry, 010402 general chemistry, Topology, 01 natural sciences, 0104 chemical sciences, chemistry.chemical_compound, Monomer, Planar, Self assembling, Ovoid, Moiety, [CHIM]Chemical Sciences, Xylylene, CSOB, Topology (chemistry)
Abstract: The topology of ß-cyclodextrin can be molded, from toroidal to ovoid basket-shaped, by the installation of an o- or m-xylylene moiety connecting two consecutive d-glucopyranosyl units through the secondary O-2(I) and O-3(II) positions. This strategy can be exploited advantageously to precast the cavity for preferential inclusion of globular or planar guests as well as to privilege dimeric or monomeric species in water solution., This study was supported by the Spanish Ministerio de Economía y Competitividad (contract numbers CTQ2015-64425-C2-1-R, CTQ2016-80600-P and SAF2016-76083-R), the Junta de Andalucía (contract number FQM2012-1467), the UAH (CCGP2017-EXP/027) and the European Regional Development Funds (FEDER and FSE). Technical assistance from the research support services of the University of Seville (CITIUS) is also acknowledged. T.N. acknowledges the Junta de Andalucía for a doctoral fellowship.
Published: 2018

29. Mechanocatalytic Depolymerization of Cellulose With Perfluorinated Sulfonic Acid Ionomers

Author: Ayman Karam, Prince N. Amaniampong, José M. García Fernández, Claudio Oldani, Sinisa Marinkovic, Boris Estrine, Karine De Oliveira Vigier, François Jérôme, Ministerio de Economía y Competitividad (MINECO). España, Junta de Andalucía, Institut de Chimie des Milieux et Matériaux de Poitiers (IC2MP), Université de Poitiers-Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Instituto de Investigaciones Químicas (IIQ), Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Solvay Specialty Polymers, and ARD Agroind Rech & Dev, Green Chem Dept
Subjects: Solid acid, Sulfonic acid, 010402 general chemistry, 01 natural sciences, Catalysis, lcsh:Chemistry, chemistry.chemical_compound, mechanocatalysis, Organic chemistry, depolymerization, Biomass, Cellulose, Aquivion, Ionomer, ComputingMilieux_MISCELLANEOUS, Original Research, chemistry.chemical_classification, biomass, 010405 organic chemistry, Depolymerization, [CHIM.CATA]Chemical Sciences/Catalysis, General Chemistry, Water soluble fraction, cellulose, 0104 chemical sciences, Chemistry, Water soluble, chemistry, lcsh:QD1-999, Mechanocatalysis
Abstract: Here, we investigated that the mechanocatalytic depolymerization of cellulose in the presence of Aquivion, a sulfonated perfluorinated ionomer. Under optimized conditions, yields of water soluble sugars of 90-97% were obtained using Aquivion PW98 and PW66, respectively, as a solid acid catalyst. The detailed characterization of the water soluble fraction revealed (i) the selective formation of oligosaccharides with a DP up to 11 and (ii) that depolymerization and reversion reactions concomitantly occurred during the mechanocatalytic process, although the first largely predominated. More importantly, we discussed on the critical role of water contained in Aquivion and cellulose on the efficiency of the mechanocatalytic process.
Published: 2017

30. Polyvalent C-glycomimetics based on l-fucose or d-mannose as potent DC-SIGN antagonists

Author: Martina Hlaváčková, Jitka Moravcová, Franck Fieschi, Martina Kašáková, Renato Ribeiro-Viana, Benedetta Bertolotti, Javier Rojo, Kamil Parkan, Ieva Sutkeviciute, Hana Dvořáková, Martino Ambrosini, Kateřina Nováková, Department of Chemistry of Natural Compounds, University of Chemistry and Technology Prague (UCT Prague), Institut de biologie structurale (IBS - UMR 5075 ), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Department of molecular cell biology and immunology, VU University Medical Center [Amsterdam], Glycosystems Laboratory, Instituto de Investigaciones Químicas (IIQ), Universidad de Sevilla / University of Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Universidad de Sevilla / University of Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Laboratory of NMR, Central Laboratories, Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB / CAS), Czech Academy of Sciences [Prague] (CAS), Ministerio de Economía y Competitividad (España), European Commission, Agence Nationale de la Recherche (France), Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), and Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Universidad de Sevilla
Subjects: Stereochemistry, Convergent synthesis, Mannose, Receptors, Cell Surface, 010402 general chemistry, 01 natural sciences, Biochemistry, Fucose, Inhibitory Concentration 50, chemistry.chemical_compound, Biomimetic Materials, Glycomimetic, Dendrimer, Lectins, C-Type, Physical and Theoretical Chemistry, biology, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], 010405 organic chemistry, Organic Chemistry, Lectin, Biological activity, 0104 chemical sciences, DC-SIGN, chemistry, biology.protein, Cell Adhesion Molecules
Abstract: The C-Type lectin DC-SIGN expressed on immature dendritic cells is a promising target for antiviral drug development. Previously, we have demonstrated that mono-and divalent C-glycosides based on d-manno and l-fuco configurations are promising DC-SIGN ligands. Here, we described the convergent synthesis of C-glycoside dendrimers decorated with 4, 6, 9, and 12 α-l-fucopyranosyl units and with 9 and 12 α-d-mannopyranosyl units. Their affinity against DC-SIGN was assessed by surface plasmon resonance (SPR) assays. For comparison, parent O-glycosidic dendrimers were synthesized and tested, as well. A clear increase of both affinity and multivalency effect was observed for C-glycomimetics of both types (mannose and fucose). However, when dodecavalent C-glycosidic dendrimers were compared, there was no difference in affinity regarding the sugar unit (l-fuco, IC 17 μM; d-manno, IC 12 μM). For the rest of glycodendrimers with l-fucose or d-mannose attached by the O-or C-glycosidic linkage, C-glycosidic dendrimers were significantly more active. These results show that in addition to the expected physiological stability, the biological activity of C-glycoside mimetics is higher in comparison to the corresponding O-glycosides and therefore these glycomimetic multivalent systems represent potentially promising candidates for targeting DC-SIGN., Financial support by the EU-ITN CARMUSYS (PITN-GA-2008-213592) and MINECO (CTQ2014-52328P) co-financed by European Regional Development Funds (ERDF) is gratefully acknowledged. For DC-SIGN ECD production, this work used the Multistep Protein Purification Platform (MP3) and the SPR platform for the competition test of the Grenoble Instruct Centre (ISBG; UMS 3518 CNRS-CEA-UJF-EMBL) with support from FRISBI (ANR-10-INSB-05-02) and GRAL (ANR-10-LABX-49-01) within the Grenoble Partnership for Structural Biology. info:eu-repo/grantAgreement/EC/FP7/213592
Published: 2017

31. Crystal structure, NIR luminescence and X-ray computed tomography of Nd3+:Ba0.3Lu0.7F2.7 nanospheres

Author: Arnaud Briat, Fernando Cussó, Manuel Ocaña, Damien Boyer, Daniel González-Mancebo, Eugenio Cantelar, Ana I. Becerro, González-Mancebo, Daniel [0000-0003-4156-2918], Universidad de Sevilla. Departamento de Química Inorgánica, Ministerio de Economía y Competitividad (MINECO). España, Consejo Superior de Investigaciones Científicas (CSIC), González-Mancebo, Daniel, Instituto de Ciencia de Materiales de Sevilla (ICMSE), Universidad de Sevilla / University of Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Departamento de Física de Materiales [Madrid], Universidad Autónoma de Madrid (UAM), Imagerie Moléculaire et Stratégies Théranostiques (IMoST), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Institut de Chimie de Clermont-Ferrand (ICCF), SIGMA Clermont (SIGMA Clermont)-Institut de Chimie du CNRS (INC)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Universidad Autonoma de Madrid (UAM), and Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: Materials science, Luminescence, Analytical chemistry, 02 engineering and technology, Crystal structure, Cubic crystal system, 010402 general chemistry, 01 natural sciences, Ion, Inorganic Chemistry, chemistry.chemical_compound, [CHIM]Chemical Sciences, Solubility, Computed tomography, Doping, 021001 nanoscience & nanotechnology, 0104 chemical sciences, 3. Good health, Rare earth fluorides, Crystallography, chemistry, Excited state, 0210 nano-technology, Ethylene glycol, Nanospheres
Abstract: Uniform, hydrophilic 50 nm diameter Nd3+-doped Ba0.3Lu0.7F2.7 nanospheres are synthesized at 120 °C using a singular one-pot method based on the use of ethylene glycol as solvent, in the absence of any additive. The composition and crystal structure of the undoped material are analyzed in detail using ICP and XRD, which reveals a BaF2 cubic crystal structure that is able to incorporate 70 mol% of Lu ions. This finding contrasts with the reported phase diagram of the system, where the maximum solubility is around 30 mol% Lu. XRD proves as well that the Ba0.3Lu0.7F2.7 structure is able to incorporate Nd3+ ions up to, at least 10 mol%, without altering the uniform particles morphology. The Nd-doped particles exhibit nearinfrared luminescence when excited at 810 nm. The maximum emission intensity with the minimum concentration quenching effect is obtained at 1.5% Nd doping level. X-ray computed tomography experiments are carried out on powder samples of the latter composition. The sample significantly absorbs X-ray photons, thus demonstrating that the Nd3+-doped Ba0.3Lu0.7F2.7 nanospheres are good candidates as contrast agents in computed tomography.
Published: 2017

32. A multivalent inhibitor of the DC-SIGN dependent uptake of HIV-1 and Dengue virus

Author: Mario Clerici, Javier Rojo, Ieva Sutkeviciute, Rasika Ramdasi, Franck Fieschi, Gerolamo Vettoretti, Anna Daghetti, Ali Amara, Anna Bernardi, Renato Ribeiro-Viana, Norbert Varga, Angela Berzi, Institut de biologie structurale (IBS - UMR 5075 ), Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), Department of Biomedical and Clinical Sciences, University of Milan, Pathologie cellulaire : aspects moléculaires et viraux / Pathologie et Virologie Moléculaire, Institut Universitaire d'Hématologie (IUH), Université Paris Diderot - Paris 7 (UPD7)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS), Department of Physics [Toronto], University of Toronto, Department of Physiopatology and Transplantation, University of Milan (DEPT), Glycosystems Laboratory, Instituto de Investigaciones Químicas (IIQ), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Universidad de Sevilla, inconnu, Inconnu, Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Università degli Studi di Milano = University of Milan (UNIMI), Universidad de Sevilla / University of Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Universidad de Sevilla / University of Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Université Paris Diderot - Paris 7 (UPD7)-Université Paris Diderot - Paris 7 (UPD7)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: genetic structures, Dengue virus, MESH: Dengue Virus, medicine.disease_cause, 01 natural sciences, Dengue fever, Dengue, MESH: HIV-1, Glycomimetic, Nanotechnology, Glycosides, Receptor, MESH: Receptors, Cell Surface, 0303 health sciences, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], biology, MESH: Surface Plasmon Resonance, 3. Good health, Raji cell, DC-SIGN, Mechanics of Materials, MESH: Cell Adhesion Molecules, MESH: Antiviral Agents, Dendrimers, Biophysics, Receptors, Cell Surface, Bioengineering, 010402 general chemistry, Antiviral Agents, Cell Line, Biomaterials, 03 medical and health sciences, Viral entry, Glycodendrimers, medicine, Humans, Lectins, C-Type, Antigen-presenting cell, 030304 developmental biology, MESH: Humans, MESH: Dendrimers, HIV, Dengue Virus, Surface Plasmon Resonance, medicine.disease, Virology, MESH: Cell Line, 0104 chemical sciences, Glycomimetics, HIV-1, Ceramics and Composites, biology.protein, Cell Adhesion Molecules, MESH: Lectins, C-Type
Abstract: International audience; DC-SIGN is a C-type lectin receptor on antigen presenting cells (dendritic cells) which has an important role in some viral infection, notably by HIV and Dengue virus (DV). Multivalent presentation of carbohydrates on dendrimeric scaffolds has been shown to inhibit DC-SIGN binding to HIV envelope glycoprotein gp120, thus blocking viral entry. This approach has interesting potential applications for infection prophylaxis. In an effort to develop high affinity inhibitors of DC-SIGN mediated viral entry, we have synthesized a group of glycodendrimers of different valency that bear different carbohydrates or glycomimetic DC-SIGN ligands and have studied their DC-SIGN binding activity and antiviral properties both in an HIV and a Dengue infection model. Surface Plasmon Resonance (SPR) competition studies have demonstrated that the materials obtained bind efficiently to DC-SIGN with IC50s in the μm range, which depend on the nature of the ligand and on the valency of the scaffold. In particular, a hexavalent presentation of the DC-SIGN selective antagonist 4 displayed high potency, as well as improved accessibility and chemical stability relative to previously reported dendrimers. At low μm concentration the material was shown to block both DC-SIGN mediated uptake of DV by Raji cells and HIV trans-infection of T cells.
Published: 2014

33. Structure, electrochemical properties and functionalization of amorphous CN films deposited by femtosecond pulsed laser ablation

Author: Florence Garrelie, Teresa C. Rojas, Carole Chaix, Florent Bourquard, Juan Carlos Sánchez-López, N. Zehani, Krzysztof Wolski, Nicole Jaffrezic-Renault, Mohamed Braiek, Chiranjeevi Maddi, Anne-Sophie Loir, Florence Lagarde, Philippe Fortgang, Vincent Barnier, C. Donnet, Teddy Tite, Université de Lyon, Laboratoire Hubert Curien [Saint Etienne] (LHC), Université Jean Monnet [Saint-Étienne] (UJM)-Centre National de la Recherche Scientifique (CNRS)-Institut d'Optique Graduate School (IOGS), Laboratoire Georges Friedel (LGF-ENSMSE), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Interfaces & biosensors - Interfaces & biocapteurs, Institut des Sciences Analytiques (ISA), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Instituto de Ciencia de Materiales de Sevilla (ICMSE), Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), and Agence Nationale de la Recherche (France)
Subjects: Materials science, CARBON NITRIDE FILMS, Carbon nitride, ELECTRODES, Analytical chemistry, Pulsed laser deposition, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, [SPI.MAT]Engineering Sciences [physics]/Materials, chemistry.chemical_compound, THIN-FILMS, SUBSTRATE, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, Materials Chemistry, Electrochemistry, Electrical and Electronic Engineering, Thin film, High-resolution transmission electron microscopy, Functionalization, X-RAY PHOTOELECTRON, TEMPERATURE, COATINGS, Mechanical Engineering, General Chemistry, 021001 nanoscience & nanotechnology, Carbon nitrides, 0104 chemical sciences, Electronic, Optical and Magnetic Materials, Amorphous solid, Carbon film, chemistry, Amorphous carbon, 13. Climate action, CLICK CHEMISTRY, BONDING STRUCTURE, Cyclic voltammetry, 0210 nano-technology, FIELD-EMISSION
Abstract: Amorphous carbon nitride (a-C:N) material has attracted much attention in research and development. Recently, it has become a more promising electrode material than conventional carbon based electrodes in electrochemical and biosensor applications. Nitrogen containing amorphous carbon (a-C:N) thin films have been synthesized by femtosecond pulsed laser deposition (fs-PLD) coupled with plasma assistance through Direct Current (DC) bias power supply. During the deposition process, various nitrogen pressures (0 to 10 Pa) and DC bias (0 to ¿ 350 V) were used in order to explore a wide range of nitrogen content into the films. The structure and chemical composition of the films have been studied by using Raman spectroscopy, electron energy-loss spectroscopy (EELS) and high-resolution transmission electron microscopy (HRTEM). Increasing the nitrogen pressure or adding a DC bias induced an increase of the N content, up to 21 at.%. Nitrogen content increase induces a higher sp2 character of the film. However DC bias has been found to increase the film structural disorder, which was detrimental to the electrochemical properties. Indeed the electrochemical measurements, investigated by cyclic voltammetry (CV), demonstrated that a-C:N film with moderate nitrogen content (10 at.%) exhibited the best behavior, in terms of reversibility and electron transfer kinetics. Electrochemical grafting from diazonium salts was successfully achieved on this film, with a surface coverage of covalently bonded molecules close to the dense packed monolayer of ferrocene molecules. Such a film may be a promising electrode material in electrochemical detection of electroactive pollutants on bare film, and of biopathogen molecules after surface grafting of the specific affinity receptor., This work is produced with the financial support of the Future Program Lyon Saint-Etienne (PALSE) from the University of Lyon (ANR-11-IDEX-0007), under the “Investissements d'Avenir” program managed by the National Agency Research (ANR).
Published: 2016

34. Transparent polycrystalline Sr: RE Ga3O7 melilite ceramics: Potential phosphors for tuneable solid state lighting

Author: Stéphane Petoud, Ana I. Becerro, Sandra Ory, Marina Boyer, Guy Matzen, Pierre Aballea, Svetlana V. Eliseeva, Sandrine Villette, Mathieu Allix, Alberto José Fernández Carrión, Agence Nationale de la Recherche (France), Junta de Andalucía, Ministerio de Economía y Competitividad (España), Institut National de la Santé et de la Recherche Médicale (France), Conditions Extrêmes et Matériaux : Haute Température et Irradiation (CEMHTI), Université d'Orléans (UO)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université d'Orléans (UO), Instituto de Ciencia de Materiales de Sevilla (ICMSE), Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Centre de biophysique moléculaire (CBM), Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), ANR-12-JS08-0002, Agence Nationale de la Recherche, MAT2014-54852-R, Consejo Superior de Investigaciones Científicas, Frapart, Isabelle, Universidad de Sevilla / University of Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), and Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Materials science, Mineralogy, Phosphor, 02 engineering and technology, engineering.material, 010402 general chemistry, 01 natural sciences, law.invention, Tetragonal crystal system, law, [CHIM] Chemical Sciences, Materials Chemistry, [CHIM]Chemical Sciences, Ceramic, Crystallization, [CHIM.MATE] Chemical Sciences/Material chemistry, business.industry, Doping, Melilite, General Chemistry, [CHIM.MATE]Chemical Sciences/Material chemistry, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Solid-state lighting, visual_art, engineering, visual_art.visual_art_medium, Optoelectronics, Crystallite, 0210 nano-technology, business
Abstract: Full and congruent crystallization from glass is applied to the SrREGaO melilite family (RE = Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb and Y). This innovative process enables the synthesis of polycrystalline ceramics exhibiting high transparency both in the visible and near infrared regions, despite tetragonal crystal structures and micrometer scale grain sizes. Moreover, glass crystallization provides an original route to synthesize new crystalline phases which are not accessible via a classic solid state reaction, as demonstrated for SrYbGaO and SrTmGaO. To illustrate the potential optical applications of such materials, SrGdGaO transparent polycrystalline ceramics are doped with Dy or Tb/Eu in order to generate white light emission under UV excitation. It is foreseen that such transparent melilite ceramic phosphors, prepared via a cost-effective process, can be successfully used in solid state lighting devices of considerable technological interest., The authors thank the French ANR for its financial support to the projects CrystOG ANR-12-JS08-0002 and FOCAL ANR-14-CE07-0002 and the ICMN (Orléans, France) and CME (Orléans, France) laboratories for the TEM and PIPS access. A. J. F.-C. gratefully acknowledges an F. P. D. I. grant from Junta de Andalucia. The work was also supported by MINECO (Project. MAT2014-54852-R). S. P. acknowledges support from INSERM.
Published: 2016

35. Simultaneous Production of CH4 and H2 from Photocatalytic Reforming of Glucose Aqueous Solution on Sulfated Pd-TiO2 Catalysts

Author: Giuseppe Sarno, Diana Sannino, María Hidalgo, Luigi Rizzo, Julie Joseane Murcia Mesa, Vincenzo Vaiano, José Antonio Navío, Giuseppina Iervolino, Università degli Studi di Salerno (UNISA), Universidad Pedagógica y Tecnológica de Colombia (UPTC), Instituto de Ciencia de Materiales de Sevilla (ICMSE), and Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)
Subjects: [PHYS]Physics [physics], Aqueous solution, Chromatography, Chemistry, General Chemical Engineering, Fluorescence spectrometry, Energy Engineering and Power Technology, chemistry.chemical_element, lcsh:Chemical technology, lcsh:HD9502-9502.5, 7. Clean energy, lcsh:Energy industries. Energy policy. Fuel trade, Catalysis, Fuel Technology, X-ray photoelectron spectroscopy, Photocatalysis, lcsh:TP1-1185, Particle size, Selectivity, Nuclear chemistry, Palladium
Abstract: International audience; In this work, the simultaneous production of CH4 and H2 from photocatalytic reforming of glucose aqueous solution on Pd-TiO2 catalysts under UV light irradiation by Light-Emitting Diodes (LED) was investigated. The Pd-TiO2 catalysts were prepared by the photodeposition method. The Pd content was in the range 0.5-2 wt% and a photodeposition time in the range 15-120 min was used. Pd-TiO2 powders were extensively characterized by X-Ray Diffraction (XRD), SBET, X-Ray Fluorescence spectrometry (XRF), UV-Vis Diffuse Reflectance Spectra (UV-Vis DRS), TEM and X-Ray Photoelectron spectroscopy (XPS). It was found that the lower Pd loading (0.5 wt%) and 120 min of photodeposition time allowed us to obtain homogeneously distributed metal nanoparticles of small size; it was also observed that the increase in the metal loading and deposition time led to increasing the Pd0 species effectively deposited on the sulfated TiO2 surface. Particle size and the oxidation state of the palladium were the main factors influencing the photocatalytic activity and selectivity. The presence of palladium on the sulfated titania surface enhanced the H2 and CH4 production. In fact, on the catalyst with 0.5 wt% Pd loading and 120 min of photodeposition time, H2 production of about 26 μmol was obtained after 3 h of irradiation time, higher than that obtained with titania without Pd (about 8.5 μmol). The same result was obtained for the methane production. The initial pH of the solution strongly affected the selectivity of the system. In more acidic conditions, the production of H2 was enhanced, while the CH4 formation was higher under alkaline conditions.
Published: 2015

36. DC nitrogen plasma assisted Femtosecond Pulsed Laser Deposition of Carbon-Nitrogen alloy for environmental analytical Microsystems: thin films characterization and in situ plume analysis

Author: Maddi, Chiranjeevi, Bourquard, Florent, Tite, Teddy, Zehani, Nedjla, Fortgang, Philippe, Loir, A.-S., Barnier, Vincent, Namour, Philippe, Lagarde, Florence, Rojas, Teresa-Cristina, Sanchez-Lopez, Juan Carlos, Chaix, Carole, Jaffrezic-Renault, Nicole, Wolski, Krzysztof, Donnet, Christophe, Garrelie, Florence, Laboratoire Hubert Curien [Saint Etienne] (LHC), Université Jean Monnet [Saint-Étienne] (UJM)-Centre National de la Recherche Scientifique (CNRS)-Institut d'Optique Graduate School (IOGS), Interfaces & biosensors - Interfaces & biocapteurs, Institut des Sciences Analytiques (ISA), Institut de Chimie du CNRS (INC)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Département Mécanique physique et interfaces (MPI-ENSMSE), École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-SMS, River Monitoring & Management - Suivi et gestion des rivières (2014-2016), Instituto de Ciencia de Materiales de Sevilla (ICMSE), and Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)
Subjects: [PHYS]Physics [physics], [PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci], [PHYS.COND]Physics [physics]/Condensed Matter [cond-mat], ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2015

37. Laser technologies for the development of carbon materials on flexible substrates for environmental analytical microsystems

Author: Chiranjeevi Maddi, Florent Bourquard, Teddy Tite, Zehani, N., Philippe Fortang, S Loir, A., Vincent Barnier, Philippe Namour, Florence Lagarde, Teresa-Cristina Rojas, Juan Carlos Sanchez-Lopez, Carole Chaix, Jaffrezic-Renault, N., Krzysztof Wolski, Donnet, C., Florence GARRELIE, Laboratoire Hubert Curien [Saint Etienne] (LHC), Université Jean Monnet [Saint-Étienne] (UJM)-Centre National de la Recherche Scientifique (CNRS)-Institut d'Optique Graduate School (IOGS), Université de Lyon, Institut des Sciences Analytiques (ISA), Institut de Chimie du CNRS (INC)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Milieux aquatiques, écologie et pollutions (UR MALY), Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), Interfaces & biosensors - Interfaces & biocapteurs, Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université Claude Bernard Lyon 1 (UCBL), Instituto de Ciencia de Materiales de Sevilla (ICMSE), Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), SIMS - Surfaces-(bio)Interfaces - Micro & Nano Systèmes (2011-2014), Département Mécanique physique et interfaces (MPI-ENSMSE), École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-SMS, Centre Science des Matériaux et des Structures (SMS-ENSMSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Laboratoire Georges Friedel (LGF-ENSMSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Programme Avenir Lyon-Saint-Etienne (ANR-11-IDEX-0007) of Université de Lyon, within the program 'Investissements d'Avenir' operated by the French National Research Agency (ANR)., ANR-11-IDEX-0007,Avenir L.S.E.,PROJET AVENIR LYON SAINT-ETIENNE(2011), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Instituto de Scienca de Materiales de Sevilla, SIMS - Surfaces-(bio)Interfaces - Micro & Nano Systèmes, Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS), and ANR-11-IDEX-0007-02/11-IDEX-0007,Avenir L.S.E.,Avenir L.S.E.(2011)
Subjects: [SPI.OPTI]Engineering Sciences [physics]/Optics / Photonic, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2015

38. High N-content a-C:N films elaborated by femtosecond PLD with plasma assistance

Author: Teresa-Cristina Rojas, Juan Carlos Sánchez-López, Teddy Tite, Chiranjeevi Maddi, Vincent Barnier, A.-S. Loir, Krzysztof Wolski, Christophe Donnet, Florence Garrelie, Laboratoire Hubert Curien [Saint Etienne] (LHC), Institut d'Optique Graduate School (IOGS)-Université Jean Monnet [Saint-Étienne] (UJM)-Centre National de la Recherche Scientifique (CNRS), Université de Lyon, Département Mécanique physique et interfaces (MPI-ENSMSE), École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-SMS, Centre Science des Matériaux et des Structures (SMS-ENSMSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Laboratoire Georges Friedel (LGF-ENSMSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Instituto de Ciencia de Materiales de Sevilla (ICMSE), Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Université Jean Monnet [Saint-Étienne] (UJM)-Centre National de la Recherche Scientifique (CNRS)-Institut d'Optique Graduate School (IOGS), and Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Materials science, EELS, CARBON NITRIDE FILMS, Carbon nitride, Analytical chemistry, General Physics and Astronomy, 02 engineering and technology, Nitride, MW Raman spectroscopy, 01 natural sciences, Pulsed laser deposition, [SPI.MAT]Engineering Sciences [physics]/Materials, chemistry.chemical_compound, symbols.namesake, THIN-FILMS, SUBSTRATE, X-ray photoelectron spectroscopy, AMORPHOUS-CARBON, 0103 physical sciences, XPS, RAMAN-SPECTRA, Thin film, 010302 applied physics, TRIBOLOGICAL CHARACTERIZATION, DIAMOND-LIKE CARBON, PULSED-LASER DEPOSITION, Surfaces and Interfaces, General Chemistry, [CHIM.MATE]Chemical Sciences/Material chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Surfaces, Coatings and Films, Femtosecond laser, Carbon film, Amorphous carbon, chemistry, symbols, BONDING STRUCTURE, Plasma assistance, PLD, 0210 nano-technology, Raman spectroscopy, FIELD-EMISSION
Abstract: Amorphous carbon nitride (a-C:N) thin films are a interesting class of carbon-based electrode materials. Therefore, synthesis and characterization of these materials have found lot of interest in environmental analytical microsystems. Herein, we report the nitrogen-doped amorphous carbon thin film elaboration by femtosecond pulsed laser deposition (fs-PLD) both with and without a plasma assistance. The chemical composition and atomic bonding configuration of the films were investigated by multi-wavelength (MW) Raman spectroscopy, X-ray photoelectron spectroscopy (XPS) and electron energy-loss spectroscopy (EELS). The highest nitrogen content, 28 at.%, was obtained with plasma assistance. The I(D)/I(G) ratio and the G peak position increased as a function of nitrogen concentration, whereas the dispersion and full width at half maximum (FWHM) of G peak decreased. This indicates more ordered graphitic like structures in the films both in terms of topological and structural, depending on the nitrogen content. EELS investigations were correlated with MW Raman results. The interpretation of XPS spectra of carbon nitride films remains a challenge. Plasma assisted PLD in the femtosecond regime led to a significant high nitrogen concentration, which is highlighted on the basis of collisional processes in the carbon plasma plume interacting with the nitrogen plasma.
Published: 2015

39. Fabrication of Optical Multilayer Devices from Porous Silicon Coatings with Closed Porosity by Magnetron Sputtering

Author: María del Carmen Jiménez de Haro, V. Godinho, Asunción Fernández, Bertrand Lacroix, J. Caballero-Hernández, Damien Jamon, Instituto de Ciencia de Materiales de Sevilla (ICMSE), Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Spain] (CSIC), Laboratoire Hubert Curien [Saint Etienne] (LHC), Institut d'Optique Graduate School (IOGS)-Université Jean Monnet [Saint-Étienne] (UJM)-Centre National de la Recherche Scientifique (CNRS), Université Jean Monnet [Saint-Étienne] (UJM)-Centre National de la Recherche Scientifique (CNRS)-Institut d'Optique Graduate School (IOGS), and Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)
Subjects: Fabrication, Materials science, Physics::Optics, 02 engineering and technology, Substrate (electronics), 010402 general chemistry, Porous silicon, Bragg reflectors, 01 natural sciences, law.invention, Condensed Matter::Materials Science, Optics, law, General Materials Science, Porosity, ComputingMilieux_MISCELLANEOUS, [PHYS]Physics [physics], business.industry, Optical microcavity, Sputter deposition, 021001 nanoscience & nanotechnology, Distributed Bragg reflector, 0104 chemical sciences, Amorphous solid, Optoelectronics, 0210 nano-technology, business, Magnetron sputtering, Lateral gradient
Abstract: The fabrication of single-material photonic-multilayer devices is explored using a new methodology to produce porous silicon layers by magnetron sputtering. Our bottom-up methodology produces highly stable amorphous porous silicon films with a controlled refractive index using magnetron sputtering and incorporating a large amount of deposition gas inside the closed pores. The influence of the substrate bias on the formation of the closed porosity was explored here for the first time when He was used as the deposition gas. We successfully simulated, designed, and characterized Bragg reflectors and an optical microcavity that integrates these porous layers. The sharp interfaces between the dense and porous layers combined with the adequate control of the refractive index and thickness allowed for excellent agreement between the simulation and the experiments. The versatility of the magnetron sputtering technique allowed for the preparation of these structures for a wide range of substrates such as polymers while also taking advantage of the oblique angle deposition to prepare Bragg reflectors with a controlled lateral gradient in the stop band wavelengths
Published: 2015

40. New kind of micro-system based on pure or doped amorphous-carbon films designed by pulsed laser for detection of toxic metals, emerging pollutants and pathogens

Author: Chiranjeevi Maddi, Teddy Tite, Zehani, N., Philippe Fortang, S Loir, A., Vincent Barnier, Krzysztof Wolski, Teresa-Cristina Rojas, Juan Carlos Sanchez-Lopez, Christophe Donnet, Florence GARRELIE, Carole Chaix, Philippe Namour, Nicole Jaffrezic, Laboratoire Hubert Curien [Saint Etienne] (LHC), Université Jean Monnet [Saint-Étienne] (UJM)-Centre National de la Recherche Scientifique (CNRS)-Institut d'Optique Graduate School (IOGS), Institut des Sciences Analytiques (ISA), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Centre Science des Matériaux et des Structures (SMS-ENSMSE), École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Laboratoire Georges Friedel (LGF-ENSMSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS), Instituto de Ciencia de Materiales de Sevilla (ICMSE), Instituto de Scienca de Materiales de Sevilla, Milieux aquatiques, écologie et pollutions (UR MALY), Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), Institut de Chimie du CNRS (INC)-Université Claude Bernard Lyon 1 (UCBL), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), and Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)
Subjects: [SPI.OPTI]Engineering Sciences [physics]/Optics / Photonic, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2014

41. Unique DC-SIGN Clustering Activity of a Small Glycomimetic: A Lesson for Ligand Design

Author: Ieva Sutkeviciute, José J. Reina, Angela Berzi, Michel Thépaut, Sara Sattin, Aline Le Roy, Javier Rojo, John D. McGeagh, Mario Clerici, Sergei Grudinin, Anna Bernardi, Christine Ebel, Franck Fieschi, Jörg Weiser, Institut de biologie structurale (IBS - UMR 5075 ), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Department of Chemistry, Università degli Studi di Milano = University of Milan (UNIMI), Department of Biomedical and Clinical Sciences, Anterio Consult & Research GmbH, Algorithms for Modeling and Simulation of Nanosystems (NANO-D), Inria Grenoble - Rhône-Alpes, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire Jean Kuntzmann (LJK), Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS), Glycosystems Laboratory, Instituto de Investigaciones Químicas (IIQ), Universidad de Sevilla / University of Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Universidad de Sevilla / University of Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Department of Physiopatology and Transplantation, University of Milan (DEPT), Fondazione Don Carlo Gnocchi, Marie Curie ITN FP7 project CARMUSYS (PITN-GA-2008-213592), ANR-11-MONU-0006,PEPSI,Expansions Polynomiales de Structures de Protéines et Interactions(2011), Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), University of Milan, Centre National de la Recherche Scientifique (CNRS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Université Joseph Fourier - Grenoble 1 (UJF)-Université Pierre Mendès France - Grenoble 2 (UPMF)-Centre National de la Recherche Scientifique (CNRS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Université Joseph Fourier - Grenoble 1 (UJF)-Université Pierre Mendès France - Grenoble 2 (UPMF), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Universidad de Sevilla, European Commission (EC), and Agence Nationale de la Recherche. France
Subjects: ligand design, C-Type Lectin, Stereochemistry, protein-protein interactions, HIV Infections, Receptors, Cell Surface, 010402 general chemistry, Crystallography, X-Ray, 01 natural sciences, Biochemistry, Clustering, Protein–protein interaction, 03 medical and health sciences, Protein structure, Glycomimetic, C-type lectin, Biomimetics, Potency, Humans, Lectins, C-Type, Binding site, Isothermal microcalorimetry, 030304 developmental biology, 0303 health sciences, Binding Sites, biology, Molecular Structure, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], Ligand, Chemistry, HIV, General Medicine, 3. Good health, 0104 chemical sciences, Protein Structure, Tertiary, molecular modelling, DC-SIGN, Drug Design, Mannosides, Glycomimetics, biology.protein, Biophysics, HIV-1, Analytical ultracentrifugation, Molecular Medicine, Thermodynamics, pharmacology, Cell Adhesion Molecules, Ultracentrifugation
Abstract: DC-SIGN is a dendritic cell-specific C-type lectin receptor that recognizes highly glycosylated ligands expressed on the surface of various pathogens. This receptor plays an important role in the early stages of many viral infections, including HIV, which makes it an interesting therapeutic target. Glycomimetic compounds are good drug candidates for DC-SIGN inhibition due to their high solubility, resistance to glycosidases, and nontoxicity. We studied the structural properties of the interaction of the tetrameric DC-SIGN extracellular domain (ECD), with two glycomimetic antagonists, a pseudomannobioside (1) and a linear pseudomannotrioside (2). Though the inhibitory potency of 2, as measured by SPR competition experiments, was 1 order of magnitude higher than that of 1, crystal structures of the complexes within the DC-SIGN carbohydrate recognition domain showed the same binding mode for both compounds. Moreover, when conjugated to multivalent scaffolds, the inhibitory potencies of these compounds became uniform. Combining isothermal titration microcalorimetry, analytical ultracentrifugation, and dynamic light scattering techniques to study DC-SIGN ECD interaction with these glycomimetics revealed that 2 is able, without any multivalent presentation, to cluster DC-SIGN tetramers leading to an artificially overestimated inhibitory potency. The use of multivalent scaffolds presenting 1 or 2 in HIV trans-infection inhibition assay confirms the loss of potency of 2 upon conjugation and the equal efficacy of chemically simpler compound 1. This study documents a unique case where, among two active compounds chemically derived, the compound with the lower apparent activity is the optimal lead for further drug development
Published: 2014

42. Chromium removal on chitosan-based sorbents - An EXAFS/XANES investigation of mechanism

Author: Víctor L. Cruz, Emerson Meneghetti, Marisa Masumi Beppu, Eric Guibal, Alfonso Caballero, Paula Baroni, Rodrigo Silveira Vieira, Enrique Rodríguez-Castellón, Universidade Federal do Ceará = Federal University of Ceará (UFC), University of Campinas [Campinas] (UNICAMP), Pôle Matériaux Polymères Avancés (Pôle MPA), Centre des Matériaux des Mines d'Alès (C2MA), IMT - MINES ALES (IMT - MINES ALES), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-IMT - MINES ALES (IMT - MINES ALES), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Instituto de Ciencia de Materiales de Sevilla (ICMSE), Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), and Universidad de Málaga [Málaga] = University of Málaga [Málaga]
Subjects: X-ray absorption spectroscopy, Chitosan, Materials science, Sorbent, Extended X-ray absorption fine structure, Chromate conversion coating, Polymers, Inorganic chemistry, technology, industry, and agriculture, Infrared spectroscopy, Sorption, Condensed Matter Physics, [SPI]Engineering Sciences [physics], Adsorption, Metals, General Materials Science, Absorption (chemistry), XAFS (EXAFS and XANES)
Abstract: International audience; Chitosan is known to be a good sorbent for metal-containing ions as the presence of amino groups and hydroxyl functions act as effective binding sites. Its crosslinking, employing glutaraldehyde or epichlorohydrin, may change the sorption properties (sorption capacity or diffusion properties) of this biopolymer, since the available functional groups are different in each case. X-ray absorption spectroscopy (XAS), including extended X-ray absorption fine structure (EXAFS) and X-ray absorption near-edge structure (XANES), Fourier-transformed infrared spectroscopy with attenuated total reflectance device (FTIR-ATR) was used along with speciation diagrams, in order to identify the binding groups involved in chromate sorption and its mechanisms. In pristine chitosan and epichlorohydrin-crosslinked chitosan membranes, amino groups are most likely responsible for adsorption, although the contribution of hydroxyl groups cannot be excluded (especially for metal-sorbent stabilization). In this case, when adsorbed about 70% of chromate ions remain in the Cr(VI) oxidation state. In the case of glutaraldehyde-crosslinked membranes, the functional groups involved are different. Carbonyl groups and imino bonds resulting from the reaction of the crosslinking agent and amino groups - may be involved in the adsorption mechanism. Additionally, a higher fraction of chromate anions, around 44% are reduced to Cr(III) oxidation state in loaded sorbent. The presence of free aldehyde groups may explain this partial reduction.
Published: 2014

43. A new bottom-up methodology to produce silicon with closed porosity nanostructure and reduced refractive index

Author: Godinho, Vanda, Caballero-Hernandez, J., Jamon, Damien, Rojas, T. C., Shierholz, R., Garcia-Lopez, J., Ferrer, F. J., Fernandez, Arnaud, Instituto de Ciencia de Materiales de Sevilla (ICMSE), Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Faculté des Sciences appliquées [Bruxelles], Université libre de Bruxelles (ULB), Laboratoire Hubert Curien [Saint Etienne] (LHC), and Institut d'Optique Graduate School (IOGS)-Université Jean Monnet [Saint-Étienne] (UJM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: [PHYS.COND]Physics [physics]/Condensed Matter [cond-mat], ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2013

44. Perfectly Transparent Sr3Al2O6 Polycrystalline Ceramic Elaborated from Glass Crystallization

Author: Ana I. Becerro, Gaël Patton, Federico Moretti, Kholoud Al Saghir, Jean-Pierre Guin, Mathieu Allix, Domingos De Sousa Meneses, Salaheddine Alahrache, Fernando Cussó, Mariette Nivard, Manuel Ocaña, Emmanuel Véron, Guy Matzen, Sébastien Chenu, Jean-Christophe Sangleboeuf, Christophe Dujardin, Conditions Extrêmes et Matériaux : Haute Température et Irradiation ( CEMHTI ), Université d'Orléans ( UO ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Physico-Chimie des Matériaux Luminescents ( LPCML ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique ( CNRS ), LAboratoire de Recherche en Mécanique Appliquée ( LARMAUR ), Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Centre National de la Recherche Scientifique ( CNRS ), Conditions Extrêmes et Matériaux : Haute Température et Irradiation (CEMHTI), Université d'Orléans (UO)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Instituto de Ciencia de Materiales de Sevilla (ICMSE), Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Institut Lumière Matière [Villeurbanne] (ILM), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Departamento de Física de Materiales [Madrid], Universidad Autonoma de Madrid (UAM), LAboratoire de Recherche en Mécanique Appliquée (LARMAUR), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS), Universidad de Sevilla / University of Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Universidad Autónoma de Madrid (UAM), and Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)
Subjects: [ SPI.MECA.GEME ] Engineering Sciences [physics]/Mechanics [physics.med-ph]/Mechanical engineering [physics.class-ph], Materials science, [ SPI.MECA ] Engineering Sciences [physics]/Mechanics [physics.med-ph], General Chemical Engineering, Mineralogy, [PHYS.MECA.GEME]Physics [physics]/Mechanics [physics]/Mechanical engineering [physics.class-ph], 02 engineering and technology, [SPI.MECA.MSMECA]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Materials and structures in mechanics [physics.class-ph], 010402 general chemistry, 01 natural sciences, law.invention, [PHYS.MECA.MEMA]Physics [physics]/Mechanics [physics]/Mechanics of materials [physics.class-ph], chemistry.chemical_compound, law, Materials Chemistry, [ PHYS.MECA.MSMECA ] Physics [physics]/Mechanics [physics]/Materials and structures in mechanics [physics.class-ph], Ceramic, Crystallization, Composite material, Scintillation, Transparent ceramics, Strontium aluminate, General Chemistry, [PHYS.MECA]Physics [physics]/Mechanics [physics], [PHYS.MECA.MSMECA]Physics [physics]/Mechanics [physics]/Materials and structures in mechanics [physics.class-ph], [SPI.MECA]Engineering Sciences [physics]/Mechanics [physics.med-ph], 021001 nanoscience & nanotechnology, Microstructure, [ SPI.MECA.MSMECA ] Engineering Sciences [physics]/Mechanics [physics.med-ph]/Materials and structures in mechanics [physics.class-ph], 0104 chemical sciences, [SPI.MECA.GEME]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Mechanical engineering [physics.class-ph], chemistry, visual_art, [ PHYS.MECA.MEMA ] Physics [physics]/Mechanics [physics]/Mechanics of materials [physics.class-ph], [ PHYS.MECA.GEME ] Physics [physics]/Mechanics [physics]/Mechanical engineering [physics.class-ph], visual_art.visual_art_medium, Grain boundary, Crystallite, [ PHYS.MECA ] Physics [physics]/Mechanics [physics], 0210 nano-technology
Abstract: The highly visible and infrared (up to 6 ¿m) transparent Sr3Al2O6 polycrystalline ceramic was obtained by full crystallization of the corresponding glass composition. The glass synthesis and the direct congruent crystallization processes are described, and the material transparency is discussed in light of its microstructure. This new transparent ceramic exhibits a high density (i.e., complete absence of porosity) and micrometer-scale crystallites with very thin grain boundaries. These microstructural characteristics, inherent to the preparation method, minimize light scattering and demonstrate the advantages of this synthesis route compared to the high-pressure process used for the few reported transparent polycrystalline materials. This Sr3Al2O6 ceramic shows a H = 10.5 GPa hardness, a Er = 150 GPa reduced elasticity modulus, and a 9.6 × 10¿6 K¿1 thermal expansion coefficient. Such a transparent strontium aluminate ceramic opens the way to a wide range of applications, especially photonics when doped by various doping agents. As examples, the luminescence of Sr3Al2O6:Eu3+ and Sr3Al2O6:Er3+, which show strong emissions in the visible and infrared ranges, respectively, is presented. Moreover, the Sr3Al2O6:Ce3+ material was found to exhibit scintillation properties under X-ray excitation. Interestingly, the analogous Sr3Ga2O6 transparent polycrystalline ceramic material could equally be prepared using the same elaboration method, although its hygroscopicity prevents the preservation of its high transparency under normal conditions. The establishment of the key factors for the transparency of this economical and innovative synthesis method should enable the prediction of new classes of technologically relevant transparent ceramics.
Published: 2013

45. Magnetron sputtered amorphous silicon films with closed porosity: microstructure and optical properties

Author: Godinho, Vanda, Caballero-Hernandez, J., Jamon, Damien, Rojas, T. C., Schierholz, R., Garcia-Lopez, J., Ferrer, F. J., Fernandez, Arnaud, Instituto de Ciencia de Materiales de Sevilla (ICMSE), Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Faculté des Sciences appliquées [Bruxelles], Université libre de Bruxelles (ULB), Laboratoire Telecom Claude Chappe (LT2C), Université Jean Monnet [Saint-Étienne] (UJM)-Ecole d'ingenieurs Telecom Saint Etienne, and Jamon, Damien
Subjects: [PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci], [PHYS.COND.CM-MS] Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci], ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2012

46. Magnetron sputtered amorphous silicon films with closed porosity: microstructure and optical properties

Author: Godinho, Vanda, Jamon, Damien, Rojas, T. C., Garcia-Lopez, J., Fernandez, Arnaud, Instituto de Ciencia de Materiales de Sevilla (ICMSE), Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Faculté des Sciences appliquées [Bruxelles], Université libre de Bruxelles (ULB), Laboratoire Telecom Claude Chappe (LT2C), Université Jean Monnet [Saint-Étienne] (UJM)-Ecole d'ingenieurs Telecom Saint Etienne, and Jamon, Damien
Subjects: [PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci], [PHYS.COND.CM-MS] Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci], ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2012

47. Microstructural characterization of hydrophobic Ti1−xAlxN coatings with moth-eye-like surface morphology

Author: V. Godinho, Carmen López-Santos, Stéphane Lucas, Asunción Fernández, M. C. Jiménez de Haro, Teresa C. Rojas, David Philippon, Instituto de Ciencia de Materiales de Sevilla (ICMSE), Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Centre de Recherche en Physique de la Matière et du Rayonnement [Namur] (PMR), Université de Namur [Namur] (UNamur), Laboratoire de Mécanique des Contacts et des Structures [Villeurbanne] (LaMCoS), Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Junta de Andalucía, Ministerio de Ciencia e Innovación (MICIN). España, Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), and Philippon, David
Subjects: Nanostructure, Materials science, EELS, Energy-dispersive X-ray spectroscopy, 02 engineering and technology, engineering.material, 010402 general chemistry, Moth-eye-like structure, 01 natural sciences, Antireflective, Coating, Phase (matter), Materials Chemistry, Thin film, ComputingMilieux_MISCELLANEOUS, HAADF/STEM, Precipitation (chemistry), Mechanical Engineering, Electron energy loss spectroscopy, Metals and Alloys, Sputter deposition, 021001 nanoscience & nanotechnology, Hydrophobic, [PHYS.COND.CM-MS] Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci], 3. Good health, 0104 chemical sciences, Crystallography, Chemical engineering, Mechanics of Materials, engineering, [PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci], 0210 nano-technology, Ti1−xAlxN coatings
Abstract: 9 páginas, 9 figuras, 3 tablas, Ti1−xAlxN thin films with different Al content were deposited by magnetron sputtering. The combination of electron energy loss spectroscopy (EELS) and energy dispersive spectroscopy (EDS) was used to evaluate the composition of the coatings. The effect of Al content on the morphology and properties of the coatings was investigated. High resolution electron microscopy and related techniques revealed the formation of a pillared moth-eye-like nanostructure with variable size and distribution of meso- and nano-columns and different degree of open porosity that depends on the Al content on the coating. For low Al content (x ≤ 0.21) c-(Ti,Al)N highly porous columns ending in a sharp pyramidal shape present low reflectivity and high hydrophobicity. While the precipitation of h-AlN phase at the column boundaries for x = 0.71 suppresses the c-(Ti,Al)N columnar growth and produces a smother surface, with higher reflectivity and less hydrophobic character., Authors thank the financial support from EC (REGPOT AL-NANOFUNC), CSIC (201060I41 and 201060E102), Spanish Ministry MICINN (Consolider FUNCOAT) and Junta de Andalucía.
Published: 2012

48. Quantification of low levels of fluorine content in thin films

Author: Antonia Terriza, Germain Rey, Francisco J. Ferrer, J. Garcia-Lopez, Jorge Gil-Rostra, Carmen Jiménez, Francisco Yubero, Laboratoire des matériaux et du génie physique (LMGP ), Institut National Polytechnique de Grenoble (INPG)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Instituto de Ciencia de Materiales de Sevilla (ICMSE), and Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)
Subjects: 010302 applied physics, Nuclear and High Energy Physics, Range (particle radiation), Materials science, Proton, Analytical chemistry, chemistry.chemical_element, 02 engineering and technology, [CHIM.MATE]Chemical Sciences/Material chemistry, 021001 nanoscience & nanotechnology, Rutherford backscattering spectrometry, Mass spectrometry, 01 natural sciences, Carbon film, chemistry, 0103 physical sciences, Fluorine, Thin film, 0210 nano-technology, Tin, Instrumentation, ComputingMilieux_MISCELLANEOUS
Abstract: Fluorine quantification in thin film samples containing different amounts of fluorine atoms was accomplished by combining proton-Rutherford Backscattering Spectrometry (p-RBS) and proton induced gamma-ray emission (PIGE) using proton beams of 1550 and 2330 keV for p-RBS and PIGE measurements, respectively. The capabilities of the proposed quantification method are illustrated with examples of the analysis of a series of samples of fluorine-doped tin oxides, fluorinated silica, and fluorinated diamond-like carbon films. It is shown that this procedure allows the quantification of F contents as low as 1 at.% in thin films with thicknesses in the 100-400 nm range. © 2011 Elsevier B.V. All rights reserved., This work was funded by the Spanish Ministerio de Ciencia e Innovación (MAT2010-18447 and CONSOLIDER CPAN CSD2007-42 and CONSOLIDER FUNCOAT CSD2008-00023).
Published: 2012

49. Structure of TiAlN reactive sputtered coatings

Author: Denisov, V.N., Mavrin, B.B., Vinogradov, E.A., Polyakov, S.N., Kiricjenko, A.N., Gogolinsky, K.V., Useinov, A.S., Blank, V.D., Godinho, V., Fernández-Camacho, A., Technological Institute for Superhard and Novel Carbon Materials, Institute for Spectroscopy RAS, Russian Academy of Sciences [Moscow] (RAS), Institute of Spectroscopy of Russian Academy of Sciences, Instituto de Ciencia de Materiales de Sevilla (ICMSE), Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Faculté des Sciences appliquées [Bruxelles], Université libre de Bruxelles (ULB), Laboratoire de Mécanique des Contacts et des Structures [Villeurbanne] (LaMCoS), Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), and Philippon, David
Subjects: [PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci], [PHYS.COND.CM-MS] Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci], ComputingMilieux_MISCELLANEOUS
Abstract: The Raman spectra, X-ray diffraction and hardness of the TiAlN films co-deposited on the steel substrates by reactive sputtering from Ti and Al targets in a mixture of N 2 + Ar gas with two magnetrons at room temperature have been studied. From Raman spectra it is found that the position of high-frequency bands in vibrational spectra was located at 700-730 cm -1 or in the region of 830 - 850 cm -1 depending on the deposition parameters whereas it is not exceed 630 cm -1 from TiAlN of NaCl structure. It is found the two-phase structure of coatings: a small quantity of NaCl-type structure of TiAlN (TiN) and the disordered structure of the chains of polyhedra [TiN x] with x = 5 and x = 4. The chains of polyhedra [TiN x] with x = 4 are mainly formed at large discharge power of Al(Ti) target or at small content of N 2 gas. © 2012 Sumy State University.
Published: 2012

50. Synthesis and structure resolution of RbLaF4

Author: Maud Barré, Michaël Deschamps, Emmanuelle Suard, Emmanuel Véron, Dominique Massiot, Catherine Bessada, Franck Fayon, Manuel Ocaña, Florent Boucher, Anne-Laure Rollet, Valérie Montouillout, Matthew R. Suchomel, Mathieu Allix, Aymeric Sadoc, Physicochimie des Electrolytes, Colloïdes et Sciences Analytiques (PECSA), Université Pierre et Marie Curie - Paris 6 (UPMC)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Conditions Extrêmes et Matériaux : Haute Température et Irradiation (CEMHTI), Université d'Orléans (UO)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université d'Orléans (UO), Argonne National Laboratory [Lemont] (ANL), Institut Laue-Langevin (ILL), Institut des Molécules et Matériaux du Mans (IMMM), Le Mans Université (UM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Instituto de Ciencia de Materiales de Sevilla (ICMSE), Universidad de Sevilla / University of Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Institut des Matériaux Jean Rouxel (IMN), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Ecole Polytechnique de l'Université de Nantes (EPUN), Université de Nantes (UN)-Université de Nantes (UN)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), ILL, Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Ecole Polytechnique de l'Université de Nantes (EPUN), Université de Nantes (UN)-Université de Nantes (UN), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université d'Orléans (UO), and Le Mans Université (UM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Anions, Chemistry, Crystal structure, Resolution (electron density), Analytical chemistry, 02 engineering and technology, [CHIM.MATE]Chemical Sciences/Material chemistry, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, Spectral line, 0104 chemical sciences, Inorganic Chemistry, Crystallography, Heteronuclear molecule, CASTEP, Magnetic properties, Electrical conductivity, Neutron, Physical and Theoretical Chemistry, 0210 nano-technology, Luminescence, Electric field gradient, Nuclear magnetic resonance spectroscopy
Abstract: The synthesis and structure resolution of RbLaF 4 are described. RbLaF 4 is synthesized by solid-state reaction between RbF and LaF 3 at 425 °C under a nonoxidizing atmosphere. Its crystal structure has been resolved by combining neutron and synchrotron powder diffraction data refinements (Pnma, a = 6.46281(2) Å, b = 3.86498(1) Å, c = 16.17629(4) Å, Z = 4). One-dimensional 87Rb, 139La, and 19F MAS NMR spectra have been recorded and are in agreement with the proposed structural model. Assignment of the 19F resonances is performed on the basis of both 19F- 139La J-coupling multiplet patterns observed in a heteronuclear DQ-filtered J-resolved spectrum and 19F- 87Rb HMQC MAS experiments. DFT calculations of both the 19F isotropic chemical shieldings and the 87Rb, 139La electric field gradient tensors using the GIPAW and PAW methods implemented in the CASTEP code are in good agreement with the experimental values and support the proposed structural model. Finally, the conductivity of RbLaF 4 and luminescence properties of Eu-doped LaRbF 4 are investigated. © 2012 American Chemical Society.
Published: 2012

Catalog

Books, media, physical & digital resources

See catalog results

Searchworks

Select search scope, currently: Articles Catalog books, media & more in Jio Institute collections Articles journal articles & other e-resources

Search

Search Constraints

Refine your results

Search Limiters

Topic

Publication Year Range

Language

Journal

Database

Publisher

78 results on '"Universidad de Sevilla-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)"'

Search Results

Catalog

Select search scope, currently: Articles

Catalog

books, media & more in Jio Institute collections

Articles

journal articles & other e-resources