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Made available in DSpace on 2018-11-26T22:40:49Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-08-01. Added 1 bitstream(s) on 2019-10-09T18:27:56Z : No. of bitstreams: 1 S0004-282X2018000800539.pdf: 336862 bytes, checksum: 861f2018734ed5dc938f69878cf50b6e (MD5) Biogen Idec Genzyme Merck Novartis Rocha Teva Roche Sanofi-Genzyme World Federation of Neurology European Committee on Treatment and Research in Multiple Sclerosis Biogen Schering Biogen Indec Merck-Serono Teva (EMOCEMP Study-NCT) Euroimmun AG Shire Quest/Athena Diagnostics Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Bayer Partners MS Center, Harvard Medical School Distrito Federal Research Foundation (FAP-DF) Libbs Sanofi Serono Teva Pharmaceuticals Sonofi-Genzyme Novartis-PPD Merck Serono Bayer Health Care Ipsen Sanofi Genzyme The expanding therapeutic arsenal in multiple sclerosis (MS) has allowed for more effective and personalized treatment, but the choice and management of disease-modifying therapies (DMTs) is becoming increasingly complex. In this context, experts from the Brazilian Committee on Treatment and Research in Multiple Sclerosis and the Neuroimmunology Scientific Department of the Brazilian Academy of Neurology have convened to establish this Brazilian Consensus for the Treatment of MS, based on their understanding that neurologists should be able to prescribe MS DMTs according to what is better for each patient, based on up-to-date evidence and practice. We herein propose practical recommendations for the treatment of MS, with the main focus on the choice and management of DMTs, as well as present a review of the scientific rationale supporting therapeutic strategies in MS. Univ Sao Paulo, Fac Med Ribeirao Preto, Hosp Clin Ribeirao Preto, Ribeirao Preto, SP, Brazil Pontificia Univ Catolica Rio Grande do Sul, Porto Alegre, RS, Brazil Univ Sao Paulo, Fac Med, Hosp Clin, Sao Paulo, SP, Brazil Univ Fed Minas Gerais, Ctr Invest Esclerose Multipla Minas Gerais, Belo Horizonte, MG, Brazil Univ Jose Rosario Vellano, Belo Horizonte, MG, Brazil Univ Fed Estado Rio de Janeiro, Rio De Janeiro, RJ, Brazil Hosp Restauracao, Recife, PE, Brazil Clin Goncalves Dias, Curitiba, Parana, Brazil Univ Estadual Campinas, Campinas, SP, Brazil Clin Privada, Cuiaba, MT, Brazil Hosp Sao Rafael, Salvador, BA, Brazil Univ Fed Fluminense, Niteroi, RJ, Brazil Fundacac Ctr Integrado Apoio Portador Deficiencia, Joao Pessoa, Paraiba, Brazil Univ Brasilia, Brasilia, DF, Brazil Univ Catolica Brasilia, Brasilia, DF, Brazil Santa Casa Misericordia Londrina, Londrina, PR, Brazil Univ Fed Goias, Fac Med, Goiania, Go, Brazil Clin Neurol & Endocrinol, Brasilia, DF, Brazil Univ Estadual Paulista, Sao Paulo, SP, Brazil Inst Neurol Curitiba, Curitiba, Parana, Brazil Univ Regiao Joinville, Joinville, SC, Brazil Univ Fed Amazonas, Hosp Univ Getulio Vargas, Manaus, Amazonas, Brazil Pontificia Univ Catolica Sao Paulo, Sorocaba, SP, Brazil Senne Liquor Diagnost, Sao Paulo, SP, Brazil Hosp Cruz Azul, Sao Paulo, SP, Brazil Fac Sao Leopoldo Mandic, Campinas, SP, Brazil Hosp Israelita Albert Einstein, Sao Paulo, SP, Brazil Univ Fed Uberlandia, Uberlandia, MG, Brazil Hosp Base Dist Fed, Brasilia, DF, Brazil Imperial Hosp Caridade, Florianopolis, SC, Brazil Escola Bahiana Med & Saude Publ, Salvador, BA, Brazil Univ Estadual Paulista, Sao Paulo, SP, Brazil Teva (EMOCEMP Study-NCT): 61080516.4.1001.5336

Made available in DSpace on 2018-11-26T17:44:30Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-12-01 Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG) The aim of this study was to describe, for the first time, the embryogenesis and larval growth of the Paraitinga Brycon nattereri Gunther, 1864 reared in captivity. After artificial fertilization, eggs were incubated at constant temperature (similar to 19 degrees C) and collected every 15 min during the first 3 h and then every 3 h until hatching. Five larvae were collected daily over 15 days for evaluation of the length, yolk sac volume and specific growth rate. The following stages of embryonic development were identified: zygote, cleavage, gastrula, segmentation and larval. The hatching occurred after 50-54 h, with larvae poorly developed and fully depigmented, devoid of mouth and swimming capacity, presenting 6.32 mm total length and 3.64 mm(3) yolk sac volume. The mouth opening was observed between days 3-4 after hatching. The yolk sac absorption was slow during the first 3 days, increasing sharply after this period, being completed on the day 11. During this period there was a decrease in the larval growth rate. After yolk sac absorption, an increase in the growth rate was observed that coincided with the start of exogenous feeding. Cannibalism was not observed during the 15 days of evaluation. The initial development of B. nattereri was slow and poorly developed larvae in relation to other Brycon species, certainly due to the lower temperature required for egg incubation and larval rearing. Other studies are needed in order to develop techniques to improve the methods of incubating eggs and feeding larvae. Embrapa Tabuleiros Costeiros, Av Beira Mar 3250, BR-49025040 Aracaju, SE, Brazil Univ Estadual Paulista, Dept Biol & Zootecnia, Rua Moncao 226, BR-15385000 Ilha Solteira, SP, Brazil Univ Jose Rosario Vellano, Rod MG 179,Km 0,Campus Univ, BR-37130000 Alfenas, MG, Brazil Univ Fed Lavras, Dept Zootecn, POB 3037, BR-37200000 Lavras, MG, Brazil Univ Estadual Paulista, Dept Biol & Zootecnia, Rua Moncao 226, BR-15385000 Ilha Solteira, SP, Brazil FAPEMIG: CVZ-1609/06

SUMMARYThe crop rotation is a practice to protect and improve the soil properties and an alternative to improve the quality of crop residues is the application of fertilizers at the planting of cover crops. Thus, we evaluated the effect of fertilization with nitrogen, phosphorus and potassium (NPK) on organic matter production and chemical composition of cover crops succeeding the corn crop. The treatments consisted of the cultivation of Avena sativa L., Lupinus albus L., Pennisetum glaucum L., Raphanus sativus L. and Sorghum bicolor L. with (200 kg ha−1 of NPK [08-28-16] applied by broadcast seeding) and without fertilization at planting. Organic matter production by all cover crops, as well as concentrations of neutral detergent fibre (NDF) in shoots and roots of A. sativa L. and R. sativus L. were higher when they were fertilized. L. albus L. showed higher NDF and acid detergent fibre (ADF) contents than the other cover crops, with and without fertilization. Nitrogen concentration increased, but the carbon/nitrogen ratio (C/N) in the shoots of L. albus L., R. sativus L. and S. bicolor L. decreased when fertilization was applied. The use of N by the A. sativa L. and P. glaucum L. and of P and K by S. bicolor L. was 16, 54, 82 and 20% more efficient, respectively, when fertilization was applied. The A. sativa L., P. glaucum L. and R. sativus L. showed higher NDF/N, ADF/N and hemicellulose/N ratios in the fertilized treatment. Although the results obtained in this study are highly satisfactory, more research should be conducted to evaluate the decomposition of crop residues from cover crops fertilized with NPK, and the effects of this strategy on corn crops in succession.

Made available in DSpace on 2018-11-26T16:16:19Z (GMT). No. of bitstreams: 0 Previous issue date: 2015-07-01. Added 1 bitstream(s) on 2019-10-09T18:25:35Z : No. of bitstreams: 1 S1516-35982015000700231.pdf: 1934779 bytes, checksum: 775debd978577bb1995d7780bad26340 (MD5) Our objective was to investigate the effect of the replacement of aruana grass by gliricidia on the fermentative losses, chemical composition, and aerobic stability of silages. For ensiling, whole-crop aruana grass (75 d of growth) was chopped (275 g kg(-1) dry matter - DM) and ensiled alone or associated with gliricidia (270 g kg(-1) DM; 150 d of growth). For gliricidia, we used only the leaves and stalks to ensile. The evaluated treatments were different ratios of aruana grass to gliricidia (100:0, 75:25, 50:50, 25:75, and 0:100), with four replicates (mini-silos). The silage composed only of gliricidia exhibited a lower pH than the other silages. Dry matter recovery was not affected by the treatments, although effluent losses were affected. The replacement of aruana grass by gliricidia 50% at ensiling resulted in a higher lactic acid bacteria count. The aruana grass silages displayed lower protein contents and a higher neutral detergent fiber content than the gliricidia silages after 40 d of fermentation. Consequently, the silage consisting of 100% gliricidia showed higher in vitro DM digestibility, presenting an increase of 8.13% after 40 d of fermentation compared with 100% of aruana grass silage. After silo opening, the gliricidia silage was very stable (>72 h). The low quality of aruana grass silage is improved by replacing this grass with significant amounts of gliricidia (approximately 75%). Univ Jose Rosario Vellano, Programa Posgrad Ciencia Anim, Alfenas, MG, Brazil Univ Jose Rosario Vellano, Dept Agron, Alfenas, MG, Brazil Univ Estadual Paulista, Programa Posgrad Zootecnia, Jaboticabal, SP, Brazil Univ Estadual Paulista, Dept Zootecnia, Jaboticabal, SP, Brazil Univ Estadual Paulista, Programa Posgrad Zootecnia, Jaboticabal, SP, Brazil Univ Estadual Paulista, Dept Zootecnia, Jaboticabal, SP, Brazil

Made available in DSpace on 2022-04-29T09:35:27Z (GMT). No. of bitstreams: 0 Previous issue date: 2014-01-01 An experiment employing three hundred and twenty 81-week-old Lohmann LSL commercial-breed hens was conducted to compare alternative induced-molting methods with the conventional method (fasting). Induced molting lasted 28 days at most, production and quality being monitored for four periods of 28 days thereafter. A completely randomized experimental design with five treatments, eight replicates of eight birds each per plot was adopted. The following experimental treatments were applied until a loss of 26% of body weight was reached: T1-fasting, T2-wheat bran ad libitum, T3-rice bran ad libitum, T4-cracked rice ad libitum, T5-ground alfalfa ad libitum. Birds were then fed production diet ad libitum, except for those on treatment T1 (fasting) which received 30, 60 and 100 g/bird/day and then feed ad libitum. During induced molting the birds were exposed to a natural photoperiod and at day 28 that period was increased by 30 minutes/week until reaching 16 hours of light/day. The characteristics evaluated during induced molting were: feed intake, body weight changes and laying percentage. In the post-molt period, performance (feed intake, laying percentage, egg weight, egg mass, feed conversion ratio per dozen and per egg mass and percentage of broken eggs) and egg quality (specific gravity, eggshell breaking strength, percentages of eggshell, yolk, and albumen, eggshell thickness, yolk color and Haugh unit) were evaluated. Every 28 days one egg was collected from each repetition for three consecutive days for quality assessment. The use of rice bran and wheat bran is viable as molting inducers since the birds given those treatments display performance and egg quality similar to those fasted during the induced molting and also because these ingredients promote easier handling, eliminates the need for grinding and feed-mixing equipment and, being less aggressive, provide greater bird welfare. © 2014 Sociedade Brasileira de Zootecnia. Universidade Estadual Paulista 'Júlio de Mesquita Filho', Botucatu, SP Departamento de Zootecnia Universidade Estadual Paulista 'Júlio de Mesquita Filho', Botucatu, SP Departamento de Zootecnia Universidade José do Rosário Vellano, Alfenas, MG Curso de Zootecnia Universidade Estadual Paulista Júlio de Mesquita Filho, Botucatu, SP Universidade Estadual Paulista 'Júlio de Mesquita Filho', Botucatu, SP Departamento de Zootecnia Universidade Estadual Paulista 'Júlio de Mesquita Filho', Botucatu, SP Curso de Zootecnia Universidade Estadual Paulista Júlio de Mesquita Filho, Botucatu, SP

Made available in DSpace on 2013-09-27T14:54:07Z (GMT). No. of bitstreams: 1 WOS000267218200032.pdf: 296807 bytes, checksum: 337a49e7688dc326d92b0bb1270102c4 (MD5) Previous issue date: 2008-01-01 Made available in DSpace on 2013-09-30T18:15:25Z (GMT). No. of bitstreams: 1 WOS000267218200032.pdf: 296807 bytes, checksum: 337a49e7688dc326d92b0bb1270102c4 (MD5) Previous issue date: 2008-01-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T13:31:44Z No. of bitstreams: 1 WOS000267218200032.pdf: 296807 bytes, checksum: 337a49e7688dc326d92b0bb1270102c4 (MD5) Made available in DSpace on 2014-05-20T13:31:44Z (GMT). No. of bitstreams: 1 WOS000267218200032.pdf: 296807 bytes, checksum: 337a49e7688dc326d92b0bb1270102c4 (MD5) Previous issue date: 2008-01-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Baccharis dracunculifolia de Candole (DC) ( Asteraceae) is indigenous throughout southeastern Latin America and is used by local people in traditional medicine. This plant is known to be the source of resin for the highly valued Brazilian green propolis. As no information is available on the safety of high doses of B. dracunculifolia extract, we evaluated the mutagenic potential of high doses of this plant extract in vivo on peripheral blood cells of Swiss mice using the comet assay and the micronucleus test. The extract was administered by gavage at doses of 1000, 1500 and 2000 mg/kg body weight. Peripheral blood cell samples were collected 4 and 24 h after treatment for the comet assay (genotoxicity assay), and at 48 and 72 h for the micronucleus test (clastogenicity assay). The B. dracunculifolia extract was devoid of clastogenic/genotoxic activity at all doses. Univ Estadual Paulista, Fac Filosofia & Ciencias, Dept Fonoaudiol, Marilia, SP, Brazil Univ Jose Rosario Vellano, Genet Lab, Alfenas, MG, Brazil Univ Fed Amapa, Lab Pesquisa Farmacos, Macapa, AP, Brazil Univ Estadual Paulista, Fac Filosofia & Ciencias, Dept Fonoaudiol, Marilia, SP, Brazil FAPESP: 06/57514-2 FAPEMIG: 1879/02 CNPq: 306544/2006-7

A aplicação de calcário, na superfície do solo, é necessária em algumas situações agrícolas. O objetivo desse trabalho foi verificar alterações em atributos químicos de um solo de textura média, em razão da aplicação de calcário na superfície ou incorporado. O experimento foi conduzido em condições de laboratório, em colunas de PVC, delineamento inteiramente ao acaso, em esquema fatorial 2 x 4 e uma testemunha, com quatro repetições. Os tratamentos consistiram na combinação de duas doses de calcário (4 e 2 t ha-1) e 4 formas de aplicação do corretivo (aplicado na superfície, sem incorporação, e calcário incorporado nas profundidades de 0 a 5; 0 a 10 e 0 a 20 cm), além da testemunha em que não foi feita a calagem. Após 326 dias de incubação do solo com o calcário, houve efeito corretivo do calcário até 5 ou 10 cm abaixo da profundidade em que foi feita a sua aplicação ou incorporação. A aplicação de calcário, na superfície, resultou em aumento da saturação por bases do solo até 10 cm de profundidade, e até 40 cm de profundidade, quando o calcário foi incorporado nas camadas de 0 a 5, 0 a 10 ou 0 a 20 cm de profundidade. The application of lime on the soil surface is necessary in some agricultural situations. The objective of this work was to verify changes in chemical attributes of a medium texture soil as a result of lime application with and without amending. The experiment was carried out in a laboratory setting, in PVC columns, in a completely randomized design, with a 2 x 4 factorial design and a control, with four replicates, totaling 36 columns. The treatments were the combination of two lime rates (4 and 2 t ha-1) and four types of lime application (on surface without amending, and amending in layers of 0 to 5; 0 to 10 and 0 to 20 cm depths), in addition to the control, to which lime was not applied. After 326 days of soil incubation with lime, there was a corrective effect from the lime until 5 cm or 10 cm below the depth in which there was the application or amending. The application of lime resulted in increases of soil base saturation until 10 cm of depth, and until 40 cm of depth when the lime was amended in the layers of 0 to 5, 0 to 10 or 0 to 20 cm depth.