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27 results on '"Ung, Alexandre"'

1. Thrombus formation during ECMO: Insights from a detailed histological analysis of thrombus composition

Author

Staessens, Senna, Moussa, Mouhamed D., Pierache, Adeline, Rauch, Antoine, Rousse, Natacha, Boulleaux, Eric, Ung, Alexandre, Desender, Linda, Pradines, Bénédicte, Vincentelli, André, Mercier, Olaf, Labreuche, Julien, Duhamel, Alain, Van Belle, Eric, Vincent, Flavien, Dupont, Annabelle, Vanhoorelbeke, Karen, Corseaux, Delphine, De Meyer, Simon F., and Susen, Sophie

Published
2022
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4. Shear Forces Induced Platelet Clearance Is a New Mechanism of Thrombocytopenia

Author

Rauch, Antoine, primary, Dupont, Annabelle, additional, Rosa, Mickael, additional, Desvages, Maximilien, additional, Le Tanno, Christina, additional, Abdoul, Johan, additional, Didelot, Mélusine, additional, Ung, Alexandre, additional, Ruez, Richard, additional, Jeanpierre, Emmanuelle, additional, Daniel, Mélanie, additional, Corseaux, Delphine, additional, Spillemaeker, Hugues, additional, Labreuche, Julien, additional, Pradines, Bénédicte, additional, Rousse, Natacha, additional, Lenting, Peter J., additional, Moussa, Mouhamed D., additional, Vincentelli, André, additional, Bordet, Jean-Claude, additional, Staels, Bart, additional, Vincent, Flavien, additional, Denis, Cécile V., additional, Van Belle, Eric, additional, Casari, Caterina, additional, and Susen, Sophie, additional

Published
2023
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7. Arterial Pulsatility and Circulating von Willebrand Factor in Patients on Mechanical Circulatory Support

Author

Vincent, Flavien, Rauch, Antoine, Loobuyck, Valentin, Robin, Emmanuel, Nix, Christoph, Vincentelli, André, Smadja, David M., Leprince, Pascal, Amour, Julien, Lemesle, Gilles, Spillemaeker, Hugues, Debry, Nicolas, Latremouille, Christian, Jansen, Piet, Capel, Antoine, Moussa, Mouhamed, Rousse, Natacha, Schurtz, Guillaume, Delhaye, Cédric, Paris, Camille, Jeanpierre, Emmanuelle, Dupont, Annabelle, Corseaux, Delphine, Rosa, Mickaël, Sottejeau, Yoann, Barth, Svenja, Mourran, Claudia, Gomane, Valérie, Coisne, Augustin, Richardson, Marjorie, Caron, Claudine, Preda, Cristian, Ung, Alexandre, Carpentier, Alain, Hubert, Thomas, Denis, Cécile, Staels, Bart, Lenting, Peter J., Van Belle, Eric, and Susen, Sophie

Published
2018
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10. Specification and Evaluation of Plasticizer Migration Simulants for Human Blood Products: A Delphi Study

Author

Thelliez, Aurélie, primary, Hénard, Grégory, additional, Delorme, Bruno, additional, Chatellier, Sonia, additional, Danel, Cécile, additional, Ducoroy, Laurent, additional, Dupont, Annabelle, additional, Garrigue, Delphine, additional, Genay, Stéphanie, additional, Goossens, Jean-François, additional, Goossens, Laurence, additional, Havet, Coralie, additional, Hecq, Jean-Daniel, additional, Maeght, Caroline, additional, Mendel, Isabelle, additional, Najdovski, Tomé, additional, Odou, Pascal, additional, Saint-Lorant, Guillaume, additional, Ung, Alexandre, additional, Lecoeur, Marie, additional, and Décaudin, Bertrand, additional

Published
2021
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11. Specification and Evaluation of Plasticizer Migration Simulants for Human Blood Products: A Delphi Study.

Author

UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Département de pharmacie, Thelliez, Aurélie, Hénard, Grégory, Delorme, Bruno, Chatellier, Sonia, Danel, Cécile, Ducoroy, Laurent, Dupont, Annabelle, Garrigue, Delphine, Genay, Stéphanie, Goossens, Jean-François, Goossens, Laurence, Havet, Coralie, Hecq, Jean-Daniel, Maeght, Caroline, Mendel, Isabelle, Najdovski, Tomé, Odou, Pascal, Saint-Lorant, Guillaume, Ung, Alexandre, Lecoeur, Marie, Décaudin, Bertrand, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Département de pharmacie, Thelliez, Aurélie, Hénard, Grégory, Delorme, Bruno, Chatellier, Sonia, Danel, Cécile, Ducoroy, Laurent, Dupont, Annabelle, Garrigue, Delphine, Genay, Stéphanie, Goossens, Jean-François, Goossens, Laurence, Havet, Coralie, Hecq, Jean-Daniel, Maeght, Caroline, Mendel, Isabelle, Najdovski, Tomé, Odou, Pascal, Saint-Lorant, Guillaume, Ung, Alexandre, Lecoeur, Marie, and Décaudin, Bertrand

Abstract

Potentially toxic plasticizers are commonly added to polyvinyl chloride medical devices for transfusion in order to improve their flexibility and workability. As the plasticizers are not chemically bonded to the PVC, they can be released into labile blood products (LBPs) during storage. Ideally, LBPs would be used in laboratory studies of plasticizer migration from the medical device. However, short supply (i.e., limited stocks of human blood in collection centres) has prompted the development of specific simulants for each type of LBP in the evaluation of new transfusion devices. We performed a Delphi study with a multidisciplinary panel of 24 experts. In the first (qualitative) phase, the panel developed consensus definitions of the specification criteria to be met by each migration simulant. Next, we reviewed the literature on techniques for simulating the migration of plasticizers into LBPs. A questionnaire was elaborated and sent out to the experts, and the replies were synthesized in order to obtain a consensus. The qualitative study established specifications for each biological matrix (whole blood, red blood cell concentrate, plasma, and platelet concentrate) and defined the criteria required for a suitable LBP simulant. Ten criteria were suggested: physical and chemical characteristics, opacity, form, stability, composition, ability to mimic a particular clinical situation, ease and safety of use, a simulant-plastic interaction correlated with blood, and compatibility with analytical methods. The questionnaire data revealed a consensus on the use of natural products (such as pig's blood) to mimic the four LBPs. Opinions diverged with regard to synthetic products. However, an isotonic solution and a rheological property modifier were considered to be of value in the design of synthetic simulants. Consensus reached by the Delphi group could be used as a database for the development of simulants used to assess the migration of plasticizers from PVC bags into L

Published
2021

14. A novel ELISA-based diagnosis of acquired von Willebrand disease with increased VWF proteolysis

Author

Rauch, Antoine, primary, Caron, Claudine, primary, Vincent, Flavien, primary, Jeanpierre, Emmanuelle, primary, Ternisien, Catherine, primary, Boisseau, Pierre, primary, Zawadzki, Christophe, primary, Fressinaud, Edith, primary, Borel-Derlon, Annie, primary, Hermoire, Sylvie, primary, Paris, Camille, primary, Lavenu-Bombled, Cécile, primary, Veyradier, Agnès, primary, Ung, Alexandre, primary, Vincentelli, André, primary, Van Belle, Eric, primary, Lenting, Peter J., primary, Goudemand, Jenny, primary, and Susen, Sophie, additional

Published
2016
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19. 0312: Characterization of human valvular interstitial cells isolated from normal and fibrocalcified aortic valves

Author

Y Miar, Anais Arbesu, primary, Toursel, Anais, additional, Ung, Alexandre, additional, Lorenzi, Rodrigo, additional, Elkalioubie, Ahmed, additional, Dupont, Annabelle, additional, Juthier, Francis, additional, Vincentelli, André, additional, Smadja, David, additional, Staels, Bart, additional, Jude, Brigitte, additional, Belle, Eric Van, additional, Chinetti-Gbaguidi, Giulia, additional, Susen, Sophie, additional, and Corseaux, Delphine, additional

Published
2014
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21. Abstract TP433: Free Leptin And Soluble Leptin Receptor: Novel Circulating Markers Of Carotid Plaque - Related Symptomatology And Potential Role In Plaque Stability (from The Opal-lille Carotid Endarterectomy Study)

Author

Elkalioubie, Ahmed, primary, Zawadzki, Christophe, additional, Lavisse, Charlotte, additional, Chinetti-Gbaguidi, Giulia, additional, Tagzirt, Madjid, additional, Corseaux, Delphine, additional, Juthier, Francis, additional, Vaast, Bertrand, additional, Vanhoutte, Jonathan, additional, Ung, Alexandre, additional, JeanPierre, Emmanuelle, additional, Vincentelli, Andre, additional, Jude, Brigitte, additional, Haulon, Stephan, additional, Staels, Bart, additional, Susen, Sophie, additional, Van Belle, Eric, additional, and Dupont, Annabelle, additional

Published
2013
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22. The Presence of Apoptotic Bone Marrow Cells Impairs the Efficacy of Cardiac Cell Therapy

Author

Mouquet, Frederic, primary, Lemesle, Gilles, additional, Delhaye, Cedric, additional, Charbonnel, Clement, additional, Ung, Alexandre, additional, Corseaux, Delphine, additional, Fabre, Olivier, additional, Juthier, Francis, additional, Marchetti, Philippe, additional, Neviere, Remi, additional, Van Belle, Eric, additional, Jude, Brigitte, additional, and Susen, Sophie, additional

Published
2011
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23. Atherosclerotic-like process in aortic stenosis: Activation of the tissue factor–thrombin pathway and potential role through osteopontin alteration

Author

Breyne, Joke, primary, Juthier, Francis, additional, Corseaux, Delphine, additional, Marechaux, Sylvestre, additional, Zawadzki, Christophe, additional, Jeanpierre, Emmanuelle, additional, Ung, Alexandre, additional, Ennezat, Pierre-Vladimir, additional, Susen, Sophie, additional, Van Belle, Eric, additional, Le Marec, Hervé, additional, Vincentelli, André, additional, Le Tourneau, Thierry, additional, and Jude, Brigitte, additional

Published
2010
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24. Inhibition of Tissue Factor—Factor VIIa Proteolytic Activity Blunts Hepatic Metastasis in Colorectal Cancer

Author

Zerbib, Philippe, primary, Grimonprez, Alexandre, additional, Corseaux, Delphine, additional, Mouquet, Frederic, additional, Nunes, Bertrand, additional, Petersen, Lars C., additional, Susen, Sophie, additional, Ung, Alexandre, additional, Hebbar, Mohamed, additional, Pruvot, François René, additional, Chambon, Jean Pierre, additional, and Jude, Brigitte, additional

Published
2009
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25. Successful orthotopic transplantation of short tracheal segments without immunosuppressive therapy.

Author

Hysi, Ilir, Kipnis, Eric, Fayoux, Pierre, Copin, Marie-Christine, Zawadzki, Christophe, Jashari, Ramadan, Hubert, Thomas, Ung, Alexandre, Ramon, Philippe, Jude, Brigitte, and Wurtz, Alain

Abstract

OBJECTIVES: Results of tracheal transplantation have been disappointing due to of ischaemia and rejection. It has been experimentally demonstrated that results of tracheal autograft/allograft transplantation were correlated with both graft length and revascularization method. Recently, we demonstrated that heterotopic epithelium-denuded-cryopreserved tracheal allograft (TA) displayed satisfactory immune tolerance. We aimed at evaluating the results of such allografts in orthotopic transplantation according to graft length and prior heterotopic or single-stage orthotopic revascularization in a rabbit model. METHODS: Twenty New Zealand rabbits were used. Six females served as donors. Tracheal mucosa was mechanically peeled off and then the TAs were cryopreserved. Male recipients were divided into three groups receiving: (i) long TA segment with prior heterotopic revascularization (10–12 tracheal rings, n = 3); (ii) average TA segment with single-stage orthotopic revascularization (6–8 tracheal rings, n = 4); (iii) short TA segment with single-stage orthotopic revascularization (4–5 tracheal rings, n = 7). No immunosuppressive therapy was administered. Grafts were assessed bronchoscopically and upon death or sacrifice by macroscopic evaluation, histology and immunohistochemical staining for apoptosis. RESULTS: Four animals were sacrificed from Day 33 to Day 220. The survival time of other recipients was 0–47 days (mean 19.6 ± 16.7 days). Aside from three animals that died from complications, all TA segments had satisfactory stiffness, were well vascularized, showed varying levels of neoangiogenesis and inflammatory infiltration devoid of lymphocytes, and showed evidence of only low levels of apoptosis. Varying degrees of fibroblastic proliferation originating from the lamina propria were observed in the lumen of all TAs and evolved over time into collagenized fibrosis in animals surviving over 45 days. Likewise, cartilage tracheal rings exhibited central calcification deposits, which started on Day 16 and increased over time. Epithelial regeneration was constantly observed. Intense fibroblastic proliferation led to stenosis in all animals from Groups (i) and (ii) but only one of seven animals from Group (iii). CONCLUSIONS: Our results suggest that short segments of epithelium-denuded-cryopreserved TA may be reliable for tracheal transplantation in the rabbit model without problems related to graft stiffness or immune rejection. Before considering clinical applications, investigations should be conducted in larger mammals. [ABSTRACT FROM AUTHOR]

Published
2015
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26. Alterations in Neutrophil Production and Function at an Early Stage in the High-Fructose Rat Model of Metabolic Syndrome.

Author

Tagzirt, Madjid, Corseaux, Delphine, Pasquesoone, Louise, Mouquet, Frédéric, Roma-Lavisse, Charlotte, Ung, Alexandre, Lorenzi, Rodrigo, Jude, Brigitte, Elkalioubie, Ahmed, Van Belle, Eric, Susen, Sophie, and Dupont, Annabelle

Subjects
NEUTROPHILS, METABOLIC syndrome, GRANULOCYTES, FRUCTOSE, ANIMAL disease models
Abstract

BACKGROUND Although neutrophils are crucially involved in inflammation, they have received only little attention in metabolic syndrome (MetS). We hypothesized that neutrophil infiltration into adipose tissue (AT) may occur at an early stage of MetS, in association with modulation of major functions of neutrophils and of their bone marrow production. METHODS Fifty-six male Sprague-Dawley rats were fed regular (control rats (CRs)) or high-fructose (60%; fructose-fed rats (FFRs)) diets. After 6 weeks, metabolic parameters were measured. Distribution of neutrophils into AT was investigated by immunohistochemistry. Function of circulating neutrophils (activation, reactive oxygen species production, phagocytosis, and apoptosis) was determined by flow cytometry. Granulopoiesis was evaluated by measuring the number and survival characteristics of neutrophil progenitors using bone marrow culture assays and flow cytometry. RESULTS Compared with the CR group, the FFR group developed MetS (i.e., arterial hypertension, hypertriglyceridemia, fasting hyperglycemia, and greater intra-abdominal AT volume) and presented higher neutrophil infiltration into AT. At resting state, no significant difference for circulating neutrophil functions was observed between the 2 groups. In contrast, circulating neutrophils from the FFR group exhibited higher responses to phorbol-12-myristate-13-acetate for all studied functions, compared with the CR group, suggesting that early MetS induces neutrophil priming. In parallel, a diminished clonal capacity and an increased apoptosis in bone marrow–derived granulocyte progenitors and neutrophil precursors were observed in the FFR group compared with the CR group. CONCLUSIONS These results provide evidence of an increased infiltration into intra-abdominal AT and modified production, function, and phenotype of neutrophils at an early stage of high-fructose diet–induced MetS. [ABSTRACT FROM AUTHOR]

Published
2014
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27. Abstract TP433.

Author

Elkalioubie, Ahmed, Zawadzki, Christophe, Lavisse, Charlotte, Chinetti-Gbaguidi, Giulia, Tagzirt, Madjid, Corseaux, Delphine, Juthier, Francis, Vaast, Bertrand, Vanhoutte, Jonathan, Ung, Alexandre, Jeanpierre, Emmanuelle, Vincentelli, Andre, Jude, Brigitte, Haulon, Stephan, Staels, Bart, Susen, Sophie, Van Belle, Eric, and Dupont, Annabelle

Published
2013

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