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Given the challenge of definitively discriminating between chemical and nuclear explosions using seismic methods alone, surface detection of signature noble gas radioisotopes is considered a positive identification of underground nuclear explosions (UNEs). However, the migration of signature radionuclide gases between the nuclear cavity and surface is not well understood because complex processes are involved, including the generation of complex fracture networks, reactivation of natural fractures and faults, and thermo-hydro-mechanical-chemical (THMC) coupling of radionuclide gas transport in the subsurface. In this study, we provide an experimental investigation of hydro-mechanical (HM) coupling among gas flow, stress states, rock deformation, and rock damage using a unique multi-physics triaxial direct shear rock testing system. The testing system also features redundant gas pressure and flow rate measurements, well suited for parameter uncertainty quantification. Using porous tuff and tight granite samples that are relevant to historic UNE tests, we measured the Biot effective stress coefficient, rock matrix gas permeability, and fracture gas permeability at a range of pore pressure and stress conditions. The Biot effective stress coefficient varies from 0.69 to 1 for the tuff, whose porosity averages 35.3% ± 0.7%, while this coefficient varies from 0.51 to 0.78 for the tight granite (porosity