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Your search keyword '"Ummarino, Simone"' showing total 24 results
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24 results on '"Ummarino, Simone"'

1. Bone marrow niches orchestrate stem-cell hierarchy and immune tolerance

Author

Furuhashi, Kazuhiro, Kakiuchi, Miwako, Ueda, Ryosuke, Oda, Hiroko, Ummarino, Simone, Ebralidze, Alexander K., Bassal, Mahmoud A., Meng, Chen, Sato, Tatsuyuki, Lyu, Jing, Han, Min-guk, Maruyama, Shoichi, Watanabe, Yu, Sawa, Yuriko, Kato, Daisuke, Wake, Hiroaki, Reizis, Boris, Frangos, John A., Owens, David M., Tenen, Daniel G., Ghiran, Ionita C., Robson, Simon C., and Fujisaki, Joji

Published
2025
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3. Myeloid lncRNA LOUP mediates opposing regulatory effects of RUNX1 and RUNX1-ETO in t(8;21) AML

Author

Trinh, Bon Q., Ummarino, Simone, Zhang, Yanzhou, Ebralidze, Alexander K., Bassal, Mahmoud A., Nguyen, Tuan M., Heller, Gerwin, Coffey, Rory, Tenen, Danielle E., van der Kouwe, Emiel, Fabiani, Emiliano, Gurnari, Carmelo, Wu, Chan-Shuo, Angarica, Vladimir Espinosa, Yang, Henry, Chen, Sisi, Zhang, Hong, Thurm, Abby R., Marchi, Francisco, Levantini, Elena, Staber, Philipp B., Zhang, Pu, Voso, Maria Teresa, Pandolfi, Pier Paolo, Kobayashi, Susumu S., Chai, Li, Di Ruscio, Annalisa, and Tenen, Daniel G.

Published
2021
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6. NAD Modulates DNA Methylation and Cell Differentiation

Author

Ummarino, Simone, primary, Hausman, Clinton, additional, Gaggi, Giulia, additional, Rinaldi, Lucrezia, additional, Bassal, Mahmoud A., additional, Zhang, Yanzhou, additional, Seelam, Andy Joe, additional, Kobayashi, Ikei S., additional, Borchiellini, Marta, additional, Ebralidze, Alexander K., additional, Ghinassi, Barbara, additional, Trinh, Bon Q., additional, Kobayashi, Susumu S., additional, and Di Ruscio, Annalisa, additional

Published
2021
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7. Formation and recycling of an active epigenetic mark mediated by cell cycle-specific RNAs

Author

Tenen, Daniel Geoffrey, primary, Espinosa Angarica, Vladimir, additional, Kappei, Dennis, additional, Tenen, Danielle, additional, Monteleone ., Emanuele, additional, Coffey, Rory, additional, Ummarino, Simone, additional, Tirado-Magallanes, Roberto, additional, Wanet, Anais, additional, Bassal, Mahmoud, additional, Trinh, Bon Lab, additional, Sheen, Mee Rie, additional, Di Ruscio, Annalisa, additional, Benoukraf, Touati, additional, Crane-Robinson, Colyn, additional, Budnik, Bogdan, additional, Zhang, Haoran, additional, Poli, Valeria, additional, Zhang, Yanzhou, additional, Liu, Yanjing, additional, and Ebralidze, Alex K, additional

Published
2021
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9. S-Phase induced RNAs control ORC1 engagement to H2A.Z and firing of early DNA replication origins

Author

Ummarino, Simone, primary, Poluben, Larysa, additional, Ebralidze, Alex K., additional, Autiero, Ida, additional, Zhang, Yhanzou, additional, Paniza, Theodore, additional, Deshpande, Madhura, additional, Lee, Johnathan, additional, Bassal, Mahmoud, additional, Trinh, Bon Q., additional, Balk, Steven, additional, Flaumenhaft, Robert, additional, Gerhardt, Jeannine, additional, Mirkin, Sergei, additional, Tenen, Daniel G., additional, and Di Ruscio, Annalisa, additional

Published
2021
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12. Formation and recycling of an active epigenetic mark mediated by cell cycle-specific RNAs

Author

Tenen, Daniel, primary, Ebralidze, Alexander, additional, Angarica, Vladimir, additional, Liu, Yanjing, additional, Kappei, Dennis, additional, Tenen, Danielle, additional, Monteleone, Emanuele, additional, Coffey, Rory, additional, Magallanes, Roberto, additional, Ummarino, Simone, additional, Wanet, Anais, additional, Bassal, Mahmoud, additional, Trinh, Bon, additional, Sheen, Mee Rie, additional, Benoukraf, Touati, additional, Robinson, Colyn Crane, additional, Ruscio, Annalisa Di, additional, Budnik, Bogdan, additional, Zhang, Haoran, additional, Poli, Valeria, additional, and Zhang, Yanzhou, additional

Published
2021
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14. An Engineered RNA Platform to Neutralize DNMT1 Function and Control DNA Methylation for Myelodysplastic Syndrome

Author

Esposito, Carla Lucia, primary, Autiero, Ida, additional, Bassal, Mahmoud Adel, additional, Annamaria, Sandomenico, additional, Ummarino, Simone, additional, Borchiellini, Marta, additional, Ruvo, Menotti, additional, Catuogno, Silvia, additional, Ebralidze, Alexander, additional, De Franciscis, Vittorio, additional, and Di Ruscio, Annalisa, additional

Published
2020
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15. NAD modulates DNA methylation and cell differentiation

Author

Ummarino, Simone, primary, Bassal, Mahmoud A., additional, Zhang, Yanzhou, additional, Seelam, Andy Joe, additional, Kobayashi, Ikei S., additional, Borchiellini, Marta, additional, Ebralidze, Alexander K., additional, Trinh, Bon Q., additional, Kobayashi, Susumu S., additional, and Di Ruscio, Annalisa, additional

Published
2020
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16. Myeloid lncRNA LOUP Mediates Opposing Regulatory Effects of RUNX1 and RUNX1-ETO in t(8;21) AML

Author

Trinh, Bon Q., primary, Ummarino, Simone, additional, Ebralidze, Alexander K., additional, van der Kouwe, Emiel, additional, Bassal, Mahmoud A., additional, Nguyen, Tuan M., additional, Coffey, Rory, additional, Tenen, Danielle E., additional, Fabiani, Emiliano, additional, Gurnari, Carmelo, additional, Wu, Chan-Shuo, additional, Angarica, Vladimir Espinosa, additional, Zhang, Yanzhou, additional, Ying, Li, additional, Yang, Henry, additional, Heller, Gerwin, additional, Chen, Sisi, additional, Zhang, Hong, additional, Thurm, Abby R., additional, Marchi, Francisco, additional, Levantini, Elena, additional, Staber, Philipp B., additional, Zhang, Pu, additional, Voso, Maria Teresa, additional, Pandolfi, Pier Paolo, additional, Ruscio, Annalisa Di, additional, and Tenen, Daniel G., additional

Published
2020
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17. Scavenging of Labile Heme by Hemopexin is a Key Check-Point in Cancer Growth and Metastases

Author

Canesin, Giacomo, primary, Di Ruscio, Annalisa, additional, Li, Mailin, additional, Hedblom, Andreas, additional, Choudhury, Reeham, additional, Krzyzanowska, Agnieszka, additional, Ummarino, Simone, additional, Csizmadia, Eva, additional, Palominos, Macarena, additional, Stiehm, Anna, additional, Ebralidze, Alexander, additional, Chen, Shao-Yong, additional, Bassal, Mahmoud, additional, Zhao, Ping, additional, Tolosano, Emanuela, additional, Hurley, Laurence, additional, Bjartell, Anders, additional, Tenen, Daniel G., additional, and Wegiel, Barbara, additional

Published
2020
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18. Deletion of calcineurin from GFAP‐expressing astrocytes impairs excitability of cerebellar and hippocampal neurons through astroglial Na+/K+ATPase

Author

Tapella, Laura, primary, Soda, Teresa, additional, Mapelli, Lisa, additional, Bortolotto, Valeria, additional, Bondi, Heather, additional, Ruffinatti, Federico A., additional, Dematteis, Giulia, additional, Stevano, Alessio, additional, Dionisi, Marianna, additional, Ummarino, Simone, additional, Di Ruscio, Annalisa, additional, Distasi, Carla, additional, Grilli, Mariagrazia, additional, Genazzani, Armando A., additional, D'Angelo, Egidio, additional, Moccia, Francesco, additional, and Lim, Dmitry, additional

Published
2019
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20. Myeloid lncRNA LOUPmediates opposing regulatory effects of RUNX1 and RUNX1-ETO in t(8;21) AML

Author

Trinh, Bon Q., Ummarino, Simone, Zhang, Yanzhou, Ebralidze, Alexander K., Bassal, Mahmoud A., Nguyen, Tuan M., Heller, Gerwin, Coffey, Rory, Tenen, Danielle E., van der Kouwe, Emiel, Fabiani, Emiliano, Gurnari, Carmelo, Wu, Chan-Shuo, Angarica, Vladimir Espinosa, Yang, Henry, Chen, Sisi, Zhang, Hong, Thurm, Abby R., Marchi, Francisco, Levantini, Elena, Staber, Philipp B., Zhang, Pu, Voso, Maria Teresa, Pandolfi, Pier Paolo, Kobayashi, Susumu S., Chai, Li, Di Ruscio, Annalisa, and Tenen, Daniel G.

Abstract

The mechanism underlying cell type-specific gene induction conferred by ubiquitous transcription factors as well as disruptions caused by their chimeric derivatives in leukemia is not well understood. Here, we investigate whether RNAs coordinate with transcription factors to drive myeloid gene transcription. In an integrated genome-wide approach surveying for gene loci exhibiting concurrent RNA and DNA interactions with the broadly expressed Runt-related transcription factor 1 (RUNX1), we identified the long noncoding RNA (lncRNA) originating from the upstream regulatory element of PU.1(LOUP). This myeloid-specific and polyadenylated lncRNA induces myeloid differentiation and inhibits cell growth, acting as a transcriptional inducer of the myeloid master regulator PU.1. Mechanistically, LOUPrecruits RUNX1 to both the PU.1enhancer and the promoter, leading to the formation of an active chromatin loop. In t(8;21) acute myeloid leukemia (AML), wherein RUNX1 is fused to ETO, the resulting oncogenic fusion protein, RUNX1-ETO, limits chromatin accessibility at the LOUPlocus, causing inhibition of LOUPand PU.1expression. These findings highlight the important role of the interplay between cell-type–specific RNAs and transcription factors, as well as their oncogenic derivatives in modulating lineage-gene activation and raise the possibility that RNA regulators of transcription factors represent alternative targets for therapeutic development.

Published
2021
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21. Deletion of calcineurin from GFAP‐expressing astrocytes impairs excitability of cerebellar and hippocampal neurons through astroglial Na+/K+ ATPase.

Author

Tapella, Laura, Soda, Teresa, Mapelli, Lisa, Bortolotto, Valeria, Bondi, Heather, Ruffinatti, Federico A., Dematteis, Giulia, Stevano, Alessio, Dionisi, Marianna, Ummarino, Simone, Di Ruscio, Annalisa, Distasi, Carla, Grilli, Mariagrazia, Genazzani, Armando A., D'Angelo, Egidio, Moccia, Francesco, and Lim, Dmitry

Published
2020
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24. Deletion of calcineurin from GFAP-expressing astrocytes impairs excitability of cerebellar and hippocampal neurons through astroglial Na + /K + ATPase.

Author

Tapella L, Soda T, Mapelli L, Bortolotto V, Bondi H, Ruffinatti FA, Dematteis G, Stevano A, Dionisi M, Ummarino S, Di Ruscio A, Distasi C, Grilli M, Genazzani AA, D'Angelo E, Moccia F, and Lim D

Subjects
Animals, Cells, Cultured, Cerebellum metabolism, Gliosis metabolism, Mice, Knockout, Neurons metabolism, Sodium-Potassium-Exchanging ATPase metabolism, Astrocytes metabolism, Calcineurin metabolism, Glial Fibrillary Acidic Protein metabolism, Hippocampus cytology
Abstract

Astrocytes perform important housekeeping functions in the nervous system including maintenance of adequate neuronal excitability, although the regulatory mechanisms are currently poorly understood. The astrocytic Ca 2+ /calmodulin-activated phosphatase calcineurin (CaN) is implicated in the development of reactive gliosis and neuroinflammation, but its roles, including the control of neuronal excitability, in healthy brain is unknown. We have generated a mouse line with conditional knockout (KO) of CaN B1 (CaNB1) in glial fibrillary acidic protein-expressing astrocytes (astroglial calcineurin KO [ACN-KO]). Here, we report that postnatal and astrocyte-specific ablation of CaNB1 did not alter normal growth and development as well as adult neurogenesis. Yet, we found that specific deletion of astrocytic CaN selectively impairs intrinsic neuronal excitability in hippocampal CA1 pyramidal neurons and cerebellar granule cells (CGCs). This impairment was associated with a decrease in after hyperpolarization in CGC, while passive properties were unchanged, suggesting impairment of K + homeostasis. Indeed, blockade of Na + /K + -ATPase (NKA) with ouabain phenocopied the electrophysiological alterations observed in ACN-KO CGCs. In addition, NKA activity was significantly lower in cerebellar and hippocampal lysates and in pure astrocytic cultures from ACN-KO mice. While no changes were found in protein levels, NKA activity was inhibited by the specific CaN inhibitor FK506 in both cerebellar lysates and primary astroglia from control mice, suggesting that CaN directly modulates NKA activity and in this manner controls neuronal excitability. In summary, our data provide formal evidence for the notion that astroglia is fundamental for controlling basic neuronal functions and place CaN center-stage as an astrocytic Ca 2+ -sensitive switch., (© 2019 Wiley Periodicals, Inc.)

Published
2020
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