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603 results on '"Umemoto M"'

11. Vascular endothelial growth factor-D is an independent prognostic factor in epithelial ovarian carcinoma

Author

Yokoyama, Y, Charnock-Jones, DS, Licence, D, Yanaihara, A, Hastings, JM, Holland, CM, Emoto, M, Umemoto, M, Sakamoto, T, Sato, S, Mizunuma, H, and Smith, SK

Subjects
Adult, Ovarian Neoplasms, Vascular Endothelial Growth Factor C, Vascular Endothelial Growth Factor D, Endothelial Growth Factors, Middle Aged, Prognosis, Vascular Endothelial Growth Factor Receptor-3, Adenocarcinoma, Mucinous, Cystadenocarcinoma, Serous, Immunoenzyme Techniques, Lymphatic Metastasis, Biomarkers, Tumor, Humans, Female, Neoplasms, Glandular and Epithelial, Peritoneal Neoplasms, Adenocarcinoma, Clear Cell, Aged, Retrospective Studies
Abstract

We assessed the presence of vascular endothelial growth factor (VEGF)-C, VEGF-D and their receptor VEGFR-3 by immunohistochemistry in 59 epithelial ovarian carcinomas, 11 borderline tumours and 20 benign cystadenomas. VEGF-C and VEGF-D were generally expressed in tumour cells and also in endothelia adjacent to tumour nests which showed a strong staining for them. VEGFR-3 was expressed in lymphatic and vascular endothelial cells adjacent to tumour nests. Immunoreactivity was significantly more frequent as lesions progressed from a benign tumour to advanced carcinoma. A strong correlation was found between VEGF-C and VEGF-D detected in carcinoma and VEGFR-3 detected in neighbouring endothelial cells. Increased expression of VEGF-C, VEGF-D and VEGFR-3 was significantly associated with lymph node metastasis and peritoneal metastasis outside the pelvis. There was a significant correlation between the high levels of VEGF-C and VEGF-D proteins, and poor survival. The presence of VEGF-D was an independent prognostic indicator by multivariate analysis. We conclude that VEGF-C, VEGF-D and VEGFR-3 play an important role in lymphatic spread and intraperitoneal tumour development in ovarian carcinoma. Since VEGF-D was found to be an independent predictor of poor outcome, its measurement, together with other prognostic markers may improve prospective identification of patients with a poor prognosis.

Published
2020
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33. Magnetic hardening mechanism in nanocrystalline Nd2Fe14B with 0.1 at. % addition of Cr, Cu, or Zr

Author

Raviprasad, K., Ravishankar, N., Chattopadhyay, K., and Umemoto, M.

Subjects
Crystals -- Magnetic properties, Surface hardening -- Research, Flux pinning -- Research, Dislocations in crystals -- Research, Physics
Abstract

A study was conducted on the magnetic hardening mechanism in nanocrystalline Nd2Fe14B with 0.1 at% additions of Cu, Cr or Zr. Small additions of Cr or Cu were found to promote pinning-type behavior retention and marginal coercivity increase while Zr addition reduced coercivity and changed the mechanism to nucleation type. Results indicate that coercivity mechanism regulation requires both the magnetic nature and location of impurity.

Published
1998

34. Synthesis and characterization of Nd2Fe14B-25 vol % Fe nanocomposite magnets

Author

Raviprasad, K., Funakoshi, M., and Umemoto, M.

Subjects
Magnets, Permanent -- Research, Metals -- Heat treatment, Grain boundaries -- Research, Physics
Abstract

A study was conducted on the characterization and synthesis of Nd2Fe14B-25 bol % Fe nanocomposite magnets. The milling time and heat treatment temperature required for synthesis were optimized by enhancing the volume fractions of hard and soft spaces. Microstructural characterization shows that grain growth occurs and magnetic properties deteriorate at high treatment temperatures.

Published
1998

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