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5. The diagnostic utility of the “Thwaites’ system” and “lancet consensus scoring system” in tuberculous vs. non-tuberculous subacute and chronic meningitis: multicenter analysis of 395 adult patients

Author

Sulaiman, Tarek, Medi, Sai, Erdem, Hakan, Senbayrak, Seniha, Ozturk-Engin, Derya, Inan, Asuman, Civljak, Rok, Nechifor, Mihai, Akbulut, Ayhan, Crisan, Alexandru, Ozguler, Muge, Namiduru, Mustafa, Savic, Branislava, Dulovic, Olga, Pehlivanoglu, Filiz, Sengoz, Gonul, Yasar, Kadriye, Inal, Ayse Seza, Parlak, Emine, Johansen, Isik Somuncu, Kursun, Ebru, Parlak, Mehmet, Yilmaz, Emel, Yilmaz, Gulden, Gul, Hanefi Cem, Oncul, Oral, Siméon, Soline, Tattevin, Pierre, Ulu-Kilic, Aysegul, Alabay, Selma, Beovic, Bojana, Catroux, Melanie, Hansmann, Yves, Harxhi, Arjan, Sener, Alper, Ozkaya, Hacer Deniz, Cağ, Yasemin, Agalar, Canan, Vahaboglu, Haluk, Ugur, Berna Kaya, and Hasbun, Rodrigo

Published
2020
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8. CD4+ T-Cell Depression is Linked to the Severity of COVID-19 and Predicts Mortality

Author

Eryilmaz-Eren, Esma, primary, Koker, Mustafa Yavuz, additional, Ulu-Kilic, Aysegul, additional, Hurmet-Oz, Hatice Tuna, additional, Ay Altintop, Yasemin, additional, Saatci, Esma, additional, Ozsoy, Sevil, additional, Kilinc-Toker, Aysin, additional, Topaloglu, Ulas Serkan, additional, Yuksel, Recep Civan, additional, Avcilar, Huseyin, additional, Bestepe-Dursun, Zehra, additional, and Celik, Ilhami, additional

Published
2023
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12. Withdrawal of Staphylococcus aureus from intensive care units in Turkey

Author

Erdem, Hakan, Dizbay, Murat, Karabey, Selma, Kaya, Selcuk, Demirdal, Tuna, Koksal, Iftihar, Inan, Asuman, Erayman, Ibrahim, Ak, Oznur, Ulu-Kilic, Aysegul, Karasahin, Omer, Akbulut, Ayhan, Elaldi, Nazif, Yilmaz, Gulden, Candevir, Aslihan, Gul, Hanefi Cem, Gonen, Ibak, Oncul, Oral, Aslan, Turan, Azak, Emel, Tekin, Recep, Kocak Tufan, Zeliha, Yenilmez, Ercan, Arda, Bilgin, Gungor, Gokay, Cetin, Birsen, Kose, Sukran, Turan, Hale, Akalin, Halis, Karabay, Oguz, Dogan-Celik, Aygul, Albayrak, Adem, Guven, Tumer, Celebi, Guven, Ozgunes, Nail, Ersoy, Yasemin, Sirmatel, Fatma, Oztoprak, Nefise, Balkan, Ilker Inanc, Bayazit, Fatma Nurhayat, Ucmak, Hasan, Oncu, Serkan, Ozdemir, Davut, Ozturk-Engin, Derya, Bitirgen, Mehmet, Tabak, Fehmi, Akata, Filiz, Willke, Ayşe, Gorenek, Levent, Ahmed, Salman Shaheer, Tasova, Yesim, Ulcay, Asim, Dayan, Saim, Esen, Saban, Leblebicioglu, Hakan, Altun, Begin, and Unal, Serhat

Published
2013
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14. Hamsi scoring in the prediction of unfavorable outcomes from tuberculous meningitis: results of Haydarpasa-II study

Author

Erdem, Hakan, Ozturk-Engin, Derya, Tireli, Hulya, Kilicoglu, Gamze, Defres, Sylviane, Gulsun, Serda, Sengoz, Gonul, Crisan, Alexandru, Johansen, Isik Somuncu, Inan, Asuman, Nechifor, Mihai, Al-Mahdawi, Akram, Civljak, Rok, Ozguler, Muge, Savic, Branislava, Ceran, Nurgul, Cacopardo, Bruno, Inal, Ayse Seza, Namiduru, Mustafa, Dayan, Saim, Kayabas, Uner, Parlak, Emine, Khalifa, Ahmad, Kursun, Ebru, Sipahi, Oguz Resat, Yemisen, Mucahit, Akbulut, Ayhan, Bitirgen, Mehmet, Popovic, Natasa, Kandemir, Bahar, Luca, Catalina, Parlak, Mehmet, Stahl, Jean Paul, Pehlivanoglu, Filiz, Simeon, Soline, Ulu-Kilic, Aysegul, Yasar, Kadriye, Yilmaz, Gulden, Yilmaz, Emel, Beovic, Bojana, Catroux, Melanie, Lakatos, Botond, Sunbul, Mustafa, Oncul, Oral, Alabay, Selma, Sahin-Horasan, Elif, Kose, Sukran, Shehata, Ghaydaa, Andre, Katell, Dragovac, Gorana, Gul, Hanefi Cem, Karakas, Ahmet, Chadapaud, Stéphane, Hansmann, Yves, Harxhi, Arjan, Kirova, Valerija, Masse-Chabredier, Isabelle, Oncu, Serkan, Sener, Alper, Tekin, Recep, Elaldi, Nazif, Deveci, Ozcan, Ozkaya, Hacer Deniz, Karabay, Oguz, Senbayrak, Seniha, Agalar, Canan, and Vahaboglu, Haluk

Published
2015
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21. Hydrocephalus and vasculitis delay therapeutic responses in tuberculous meninigitis: Results of Haydarpasa-III study

Author

Cag, Yasemin, Ozturk-Engin, Derya, Gencer, Serap, Hasbun, Rodrigo, Sengoz, Gonul, Crisan, Alexandru, Ceran, Nurgul, Savic, Branislava, Yasar, Kadriye, Pehlivanoglu, Filiz, Kilicoglu, Gamze, Tireli, Hulya, Inal, Ayse, Civljak, Rok, Tekin, Recep, Elaldi, Nazif, Ulu-Kilic, Aysegul, Ozguler, Muge, Namiduru, Mustafa, Sunbul, Mustafa, Sipahi, Oguz, Dulovic, Olga, Alabay, Selma, Akbulut, Ayhan, Sener, Alper, Lakatos, Botond, Andre, Katell, Yemisen, Mucahit, Oncu, Serkan, Nechifor, Mihai, Deveci, Ozcan, Senbayrak, Seniha, Inan, Asuman, Dragovac, Gorana, Gül, Hanefi, Mert, Gurkan, Oncul, Oral, Kandemir, Bahar, Erol, Serpil, Agalar, Canan, and Erdem, Hakan

Subjects
Care and treatment, Complications and side effects, Research, Meningitis -- Health aspects -- Care and treatment -- Research, Tuberculosis -- Health aspects -- Complications and side effects -- Research
Published
2016

24. Central nervous system infections in the absence of cerebrospinal fluid pleocytosis

Author

Erdem, Hakan, Ozturk-Engin, Derya, Cag, Yasemin, Senbayrak, Seniha, Inan, Asuman, Kazak, Esra, Savasci, Umit, Elaldi, Nazif, Vahaboglu, Haluk, Hasbun, Rodrigo, Nechifor, Mihai, Tireli, Hulya, Kilicoglu, Gamze, Defres, Sylviane, Gulsun, Serda, Ceran, Nurgul, Crisan, Alexandru, Johansen, Isik Somuncu, Namiduru, Mustafa, Dayan, Saim, Kayabas, Uner, Parlak, Emine, Khalifa, Ahmad, Kursun, Ebru, Sipahi, Oguz Resat, Yemisen, Mucahit, Akbulut, Ayhan, Bitirgen, Mehmet, Popovic, Natasa, Kandemir, Bahar, Luca, Catalina, Parlak, Mehmet, Stahl, Jean Paul, Pehlivanoglu, Filiz, Simeon, Soline, Ulu-Kilic, Aysegul, Yasar, Kadriye, Yilmaz, Gulden, Yilmaz, Emel, Beovic, Bojana, Catroux, Melanie, Lakatos, Botond, Sunbul, Mustafa, Oncul, Oral, Alabay, Selma, Sahin-Horasan, Elif, Kose, Sukran, Shehata, Ghaydaa, Andre, Katell, Dragovac, Gorana, Gul, Hanefi Cem, Karakas, Ahmet, Chadapaud, Stéphane, Hansmann, Yves, Harxhi, Arjan, Kirova, Valerija, Masse-Chabredier, Isabelle, Oncu, Serkan, Sener, Alper, Tekin, Recep, Deveci, Ozcan, Ozkaya, Hacer Deniz, Karabay, Oguz, Agalar, Canan, Gencer, Serap, Karahocagil, Mustafa Kasim, Karsen, Hasan, Kaya, Selcuk, Pekok, Abdullah Umut, Celen, Mustafa Kemal, Deniz, Secil, Ulug, Mehmet, Demirdal, Tuna, Guven, Tumer, Bolukcu, Sibel, Avci, Meltem, Nayman-Alpat, Saygin, Yaşar, Kadriye, Pehlivanoʇlu, Filiz, Ates-Guler, Selma, Mutlu-Yilmaz, Esmeray, Tosun, Selma, Sirmatel, Fatma, Batirel, Ayşe, Öztoprak, Nefise, Kadanali, Ayten, Turgut, Huseyin, Baran, Ali Irfan, Karaahmetoglu, Gokhan, Sunnetcioglu, Mahmut, Haykir-Solay, Asli, Denk, Affan, Ayaz, Celal, Gorenek, Levent, Larsen, Lykke, Poljak, Mario, Barsic, Bruno, Argemi, Xavier, Sørensen, Signe Maj, Bohr, Anne Lisbeth, Tattevin, Pierre, Gunst, Jesper Damsgaard, Baštáková, Lenka, Jereb, Matjaž, Chehri, Mahtab, Beraud, Guillaume, Del Vecchio, Rosa Fontana, Maresca, Mauro, Yilmaz, Hava, Sharif-Yakan, Ahmad, Kanj, Souha Shararah, Korkmaz, Fatime, Komur, Suheyla, Coskuner, Seher Ayten, Ince, Nevin, Akkoyunlu, Yasemin, Halac, Gulistan, Nemli, Salih Atakan, Ak, Oznur, Gunduz, Alper, Gozel, Mustafa G., Hatipoglu, Mustafa, Cicek-Senturk, Gonul, Akcam, Fusun Z., Inkaya, Ahmet C., Sagmak-Tartar, Ayşe, Ersoy, Yasemin, Tuncer-Ertem, Gunay, Balkan, Ilker I., Cetin, Birsen, Ersoz, Gulden, Ozgunes, Nail, Yesilkaya, Aysegul, Erturk, Ayse, Gundes, Sibel, Turhan, Vedat, Yalci, Aysun, Aydin, Emsal, Diktas, Husrev, Ulcay, Asim, Seyman, Derya, Leblebicioglu, Hakan, [Erdem, Hakan -- Savasci, Umit] Gulhane Mil Med Acad, Dept Infect Dis & Clin Microbiol, Ankara, Turkey -- [Ozturk-Engin, Derya -- Senbayrak, Seniha -- Inan, Asuman] Haydarpasa Numune Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Cag, Yasemin] Lutfi Kirdar Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Kazak, Esra] Uludag Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Bursa, Turkey -- [Elaldi, Nazif] Cumhuriyet Univ, Sch Med, Dept Infect Dis & Clin Microbiol, Sivas, Turkey -- [Vahaboglu, Haluk] Medeniyet Univ, Goztepe Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Hasbun, Rodrigo] UT Hlth McGovern Med Sch, Dept Infect Dis, Houston, TX 77030 USA, Kart Yasar, Kadriye -- 0000-0003-2963-4894, Larsen, Lykke -- 0000-0002-4113-4182, VAHABOGLU, Haluk -- 0000-0001-8217-1767, Mikrobiyoloji, OMÜ, Çukurova Üniversitesi, Uludağ Üniversitesi/Tıp Fakültesi/Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, Kazak, Esra, AAG-8459-2021, and Ege Üniversitesi

Subjects
0301 basic medicine, Male, Leukocytosis, 0302 clinical medicine, CSF, Encephalitis, Leukocyte, Meningitis, Pleocytosis, Neurosyphilis, Diagnosis, Pathology, Medicine, 030212 general & internal medicine, Brucella meningitis, Middle aged, biology, Meningitis, Pneumococcal, General Medicine, Middle Aged, Central nervous system infection, Tıp, ComputingMilieux_MANAGEMENTOFCOMPUTINGANDINFORMATIONSYSTEMS, medicine.anatomical_structure, Cerebrospinal fluid, Bacterial Meningitides, Cerebrospinal Fluid, Infectious diseases, Protein cerebrospinal fluid level, Pneumococcal, Female, InformationSystems_MISCELLANEOUS, Human, Microbiology (medical), 030106 microbiology, Central nervous system, Brucella, Outcomes, Cerebrospinal fluid pleocytosis, Tuberculous meningitis, Article, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, Humans, lcsh:RC109-216, Leukocytosis/cerebrospinal fluid, Herpes simplex encephalitis, business.industry, ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS, Herpetic meningoencephalitis, Central Nervous System Infections/cerebrospinal fluid, Pneumococcal meningitis, Tuberculosis, meningeal, medicine.disease, biology.organism_classification, Meningitis, Pneumococcal/cerebrospinal fluid, ComputingMethodologies_PATTERNRECOGNITION, Tuberculosis, Meningeal/cerebrospinal fluid, Clinical feature, Immunology, business, Central nervous system infections
Abstract

WOS: 000417628500023, PubMed ID: 29081366, Previous multicenter/multinational studies were evaluated to determine the frequency of the absence of cerebrospinal fluid pleocytosis in patients with central nervous system infections, as well as the clinical impact of this condition. It was found that 18% of neurosyphilis, 7.9% of herpetic meningoencephalitis, 3% of tuberculous meningitis, 1.7% of Brucella meningitis, and 0.2% of pneumococcal meningitis cases did not display cerebrospinal fluid pleocytosis. Most patients were not immunosuppressed. Patients without pleocytosis had a high rate of unfavorable outcomes and thus this condition should not be underestimated. (C) 2017 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases., Grant-A-Starr Foundation, Grant-A-Starr Foundation.

Published
2017
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32. Hydrocephalus and vasculitis delay therapeutic responses in tuberculous meninigitis: Results of Haydarpasa-III study

Author

Erdem, Hakan, primary, Cag, Yasemin, additional, Ozturk-Engin, Derya, additional, Gencer, Serap, additional, Hasbun, Rodrigo, additional, Sengoz, Gonul, additional, Crisan, Alexandru, additional, Ceran, Nurgul, additional, Savic, Branislava, additional, Yasar, Kadriye, additional, Pehlivanoglu, Filiz, additional, Kilicoglu, Gamze, additional, Tireli, Hulya, additional, Inal, AyseS, additional, Civljak, Rok, additional, Tekin, Recep, additional, Elaldi, Nazif, additional, Ulu-Kilic, Aysegul, additional, Ozguler, Muge, additional, Namiduru, Mustafa, additional, Sunbul, Mustafa, additional, Sipahi, OguzR, additional, Dulovic, Olga, additional, Alabay, Selma, additional, Akbulut, Ayhan, additional, Sener, Alper, additional, Lakatos, Botond, additional, Andre, Katell, additional, Yemisen, Mucahit, additional, Oncu, Serkan, additional, Nechifor, Mihai, additional, Deveci, Ozcan, additional, Senbayrak, Seniha, additional, Inan, Asuman, additional, Dragovac, Gorana, additional, Gül, HanefiC, additional, Mert, Gurkan, additional, Oncul, Oral, additional, Kandemir, Bahar, additional, Erol, Serpil, additional, and Agalar, Canan, additional

Published
2016
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33. Antituberculosis drug resistance patterns in adults with tuberculous meningitis: results of haydarpasa-iv study

Author

Senbayrak, Seniha, primary, Ozkutuk, Nuri, additional, Erdem, Hakan, additional, Johansen, Isik Somuncu, additional, Civljak, Rok, additional, Inal, Ayse Seza, additional, Kayabas, Uner, additional, Kursun, Ebru, additional, Elaldi, Nazif, additional, Savic, Branislava, additional, Simeon, Soline, additional, Yilmaz, Emel, additional, Dulovic, Olga, additional, Ozturk-Engin, Derya, additional, Ceran, Nurgul, additional, Lakatos, Botond, additional, Sipahi, Oguz Resat, additional, Sunbul, Mustafa, additional, Yemisen, Mucahit, additional, Alabay, Selma, additional, Beovic, Bojana, additional, Ulu-Kilic, Aysegul, additional, Cag, Yasemin, additional, Catroux, Melanie, additional, Inan, Asuman, additional, Dragovac, Gorana, additional, Deveci, Ozcan, additional, Tekin, Recep, additional, Gul, Hanefi Cem, additional, Sengoz, Gonul, additional, Andre, Katell, additional, Harxhi, Arjan, additional, Hansmann, Yves, additional, Oncu, Serkan, additional, Kose, Sukran, additional, Oncul, Oral, additional, Parlak, Emine, additional, Sener, Alper, additional, Yilmaz, Gulden, additional, Savasci, Umit, additional, and Vahaboglu, Haluk, additional

Published
2015
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37. Clustering of Serratia marcescens infections during six years: Epidemiology and risk factors for mortality.

Author

Ulu-Kilic, Aysegul, Alp, Emine, Orhan, Tülay, Cevahir, Fatma, Ersoy, Safiye, Altun, Dilek, and Mclaws, Mary-Louise

Subjects
ACADEMIC medical centers, CHI-squared test, CROSS infection, DRUG resistance in microorganisms, EPIDEMICS, PROBABILITY theory, SERRATIA diseases, RETROSPECTIVE studies, DATA analysis software, MANN Whitney U Test
Abstract

Background: Serratia marcescens is responsible for hospital-associated infections found in clusters and outbreaks. Based on a previous outbreak in our institution, we aimed to evaluate epidemiological characteristics and risk factors for mortality of patients with S. marcescens infection in the previous five-year period. Method: A retrospective analysis of the patients with S. marcescens colonization and infection between January 2008 and December 2012 was included. Data included demographical characteristics, co-morbidities, and invasive procedures performed were obtained from the computer databases, the microbiology laboratory, and infection control surveillance data. Data were plotted monthly on process control charts including Exponentially Weighted Moving Average (EWMA) statistics. Results: We identified 378 patients colonized or infected with S. marcescens between January 2008 and December 2012. The median age of patients was 57 years (0-90 years). Of all hospitalized patients 60 (21.7%) expired and 216 (78.2%) survived. Previous ICU stay, respiratory failure, loss of consciousness, total parenteral nutrition, mechanical ventilation, intubation, central catheterization, urinary catheterization, hemodialysis, previous use of antibiotics were significant risk factors for mortality. Multivariate analysis showed that mortality risk of Serratia infection increased threefold for hemodialysis patients and fivefold for intubated patients. A mean monthly level of Serratia infections hospital-wide identified from process control chart statistics was 6.3 and ranged from 5.2-8.8 over five years. For ICU cases the mean was 1.9 and ranged over five years from 1.1 to 3.3. Conclusions: S. marcescens is an opportunistic pathogen associated with significant mortality. We documented that S. marcescens strains persisted over prolonged periods causing cluster of infections. Clinicians should consider that small clusters of S. marcescens infections are the tip of the iceberg and may be a predictor of an outbreak. [ABSTRACT FROM AUTHOR]

Published
2017

42. Molecular Characterization of Carbapenem Resistant Acinetobacter baumannii and Investigation of Genetic Diversity Between Local and International Clones.

Author

Ahmed, Salman Shaheer, Dinc, Gokcen, Rossella, Baldan, Alp, Emine, Ulu-Kilic, Aysegul, Melchers, Willem J. G., Hopman, Joost, and Voss, Andreas

Subjects
CARBAPENEMS, ACINETOBACTER baumannii, MOLECULAR cloning, NOSOCOMIAL infections, CARBAPENEMASE, MOLECULAR epidemiology
Abstract

The emergence of Carbapenem-resistant Acinetobacter baumannii is a threat to modern medicine and has been recognised globally. Epidemic clones of A.baumannii are associated with hospital epidemics throughout the world causing serious ramifications. There are number of molecular typing techniques used for molecular characterisation, however, due to lack of resources molecular epidemiology remains unfledged in developing countries. In this study a total number of 205 carbapenem-resistant Acinetobacter species were collected and compared with European Clone I, II and III. PCR for and blaOXA-51-like was performed for confirmation and multiplex PCR was performed for blaOXA-23-like, blaOXA- 24-like and blaOXA-58-like genes. Isolates harbouring carbapenemases were selected for molecular typing using PFGE, RAPD-PCR and REP-PCR and discriminatory index was performed. The cost of all molecular typing methods was calculated. The blaOXA-51-like gene was present in 188 (91.7%), and within these 188 isolates; blaOXA-23-like 36(19%), blaOXA-24-like 62(33%), 30(16%) carried blaOXA-58-like genes. PFGE typing revealed 13 clusters and 15 unique types, RAPD-PCR, 11 clusters and 23 unique types and REP-PCR, 8 clusters and no unique types. With 80% similarity cut-off value, 11 isolates were similar to EU clone I, 5 isolates were similar to EU II and 3 isolates were similar to EU III. Cost of molecular methods was compared between PFGE, RAPD-PCR and REP-PCR. PFGE was found to have high discriminatory power and RAPD-PCR was economical. [ABSTRACT FROM AUTHOR]

Published
2016

50. Tularemia: potential role of cytopathology in differential diagnosis of cervical lymphadenitis: Multicenter experience in 53 cases and literature review.

Author

Tuncer, Ersin, Onal, Binnur, Simsek, Gulcin, Elagoz, Sahande, Sahpaz, Ahmet, Kilic, Selcuk, Altuntas, Emine Elif, and Ulu Kilic, Aysegul

Subjects
LYMPHADENITIS, TULAREMIA, CELLULAR pathology, DIFFERENTIAL diagnosis, MEDICAL literature, ETIOLOGY of diseases, EPIDEMICS, SEROLOGY
Abstract

Tularemia is a zoonosis caused by Francisella tularensis. Tularemia outbreaks occurred in Central Anatolia during 2009 and 2011. We evaluated the clinical characteristics and cytomorphologies of fine needle aspirations ( FNAs) from cervical lymph nodes in serologically confirmed tularemia cases. To our knowledge, this is the first large series concerning FNA morphology of Tularemia. FNA smears of 53 patients of the 290, diagnosed by microagglutination tests and PCR, were evaluated at three Pathology centers. FNAs were performed by cytopathologists or ear-nose-throat surgeons. Of all patients, 17 had also lymph node resections. FNAs showed the presence of suppuration and abscess. Rare epithelioid histiocytes and granulomas, seldom phagocytosed bacilli-like microorganisms were observed. On histopathology; granulomas, necrosis, and suppurative inflammation extending extracapsular areas were seen. Tularemia is endemic in certain areas of the Northern Hemisphere. The benefit from cytopathology is limited and cytological suspicion should be confirmed by serology. However FNA cytology is helpful in differential diagnosis of tularemia and other diseases presented with suppurative, granulomatous cervical lymphadenitis. It is also useful in providing the material for PCR and culture in early phase when the serology is negative and the treatment is more effective. [ABSTRACT FROM AUTHOR]

Published
2014
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