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1. Psychotherapeutic Treatment for Anorexia Nervosa: A Systematic Review and Network Meta-Analysis

Author

Almut Zeeck, Beate Herpertz-Dahlmann, Hans-Christoph Friederich, Timo Brockmeyer, Gaby Resmark, Ulrich Hagenah, Stefan Ehrlich, Ulrich Cuntz, Stephan Zipfel, and Armin Hartmann

Subjects
anorexia nervosa, eating disorders, systematic review, psychotherapy, meta-analysis, Psychiatry, RC435-571
Abstract

Background: The aim of the study was a systematic review of studies evaluating psychotherapeutic treatment approaches in anorexia nervosa and to compare their efficacy. Weight gain was chosen as the primary outcome criterion. We also aimed to compare treatment effects according to service level (inpatient vs. outpatient) and age group (adolescents vs. adults).Methods:The data bases PubMed, Cochrane Library, Web of Science, Cinahl, and PsychInfo were used for a systematic literature search (until Feb 2017). Search terms were adapted for data base, combining versions of the search terms anorexia, treat*/therap* and controlled trial. Studies were selected using pre-defined in- and exclusion criteria. Data were extracted by two independent coders using piloted forms. Network-meta-analyses were conducted on all RCTs. For a comparison of service levels and age groups, standard mean change (SMC) statistics were used and naturalistic, non-randomized studies included.Results: Eighteen RCTs (trials on adults: 622 participants; trials on adolescents: 625 participants) were included in the network meta-analysis. SMC analyses were conducted with 38 studies (1,164 participants). While family-based approaches dominate interventions for adolescents, individual psychotherapy dominates in adults. There was no superiority of a specific approach. Weight gains were more rapid in adolescents and inpatient treatment.Conclusions: Several specialized psychotherapeutic interventions have been developed and can be recommended for AN. However, adult and adolescent patients should be distinguished, as groups differ in terms of treatment approaches considered suitable as well as treatment response. Future trials should replicate previous findings and be multi-center trials with large sample sizes to allow for subgroup analyses. Patient assessment should include variables that can be considered relevant moderators of treatment outcome. It is desirable to explore adaptive treatment strategies for subgroups of patients with AN. Identifying and addressing maintaining factors in AN remains a major challenge.

Published
2018
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2. Es war einmal eine Website... - Kooperative Webarchivierung in der Praxis

Author

Tobias Beinert, Ulrich Hagenah, and Anna Kugler

Subjects
Bibliography. Library science. Information resources
Abstract

Die Webarchivierung hat sich seit Ende der 1990er Jahre zu einem neuen Handlungsfeld für Bibliotheken entwickelt. Der Beitrag erläutert kurz die Bedeutung der Sammlung und dauerhaften Zugänglichmachung von Websites durch öffentliche Gedächtnisinstitutionen und beleuchtet die wichtigsten technischen Grundlagen sowie die derzeit in Deutschland geltenden rechtlichen Rahmenbedingungen. Am Beispiel des Vorgehens der Bayerischen Staatsbibliothek werden die Erfahrungen und Herausforderungen der Webarchivierung praxisnah illustriert, zudem beschreibt auch die Staats- und Universitätsbibliothek Hamburg Carl von Ossietzky ihre Voraussetzungen, Anforderungen und Ziele bei der Archivierung von Websites. Der abschließende Ausblick auf ein aktuell laufendes und von der Deutschen Forschungsgemeinschaft gefördertes Projekt zeigt, wie eine kooperative Nutzung von Infrastrukturen für die Webarchivierung umgesetzt werden kann. Web archiving has developed into a new field of action for libraries since the late 1990s. The article briefly explains the significance of the collection of and provision of permanent access to websites by public memory institutions and sheds light on the most relevant technological basics as well as the legal framework currently applicable in Germany. Exemplified by the approach of the Bavarian State Library, experiences and challenges of web archiving are illustrated with a practical emphasis. In addition to this the State and University Library Hamburg Carl von Ossietzky also describes their requirements, needs and goals for archiving websites. In conclusion, a perspective on a currently ongoing project funded by the German Research Foundation shows, how a cooperative use of infrastructure for Web archiving can be implemented successfully.

Published
2014
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3. Migration background and juvenile mental health: a descriptive retrospective analysis of diagnostic rates of psychiatric disorders in young people

Author

Tilman Jakob Gaber, Samira Bouyrakhen, Beate Herpertz-Dahlmann, Ulrich Hagenah, Martin Holtmann, Christine Margarete Freitag, Lars Wöckel, Fritz Poustka, and Florian Daniel Zepf

Subjects
immigration issues, risk factors, mental health, children, adolescents, Public aspects of medicine, RA1-1270
Abstract

Introduction: This article presents diagnostic rates for specific mental disorders in a German pediatric inpatient population over a period of 20 years with respect to migration background and socioeconomic status (SES). Methods: Diagnostic data were obtained over a period of 20 years from 8,904 patients who visited a child and adolescent psychiatry mental health service in Germany. Data from 5,985 diagnosed patients (ICD-9 and ICD-10 criteria) were included with respect to gender, migration background, and SES. Results:Migration- and gender-specific effects were found for both periods of assessment. The group of boys with a migration background showed significantly higher rates of reactions to severe stress, adjustment disorders, and posttraumatic stress disorder compared to their male, non-migrant counterparts. Conversely, boys without a migration background showed a significantly higher percentage rate of hyperkinetic disorders than male migrants. Similar results were found for female migrants in the latter assessment period (ICD-10). In addition, female migrants showed lower rates of emotional disorders whose onset occurs in childhood compared to their non-migrant counterparts. Conclusions: Data from this investigation provide preliminary evidence that the prevalence of various psychiatric disorders in children and adolescents is influenced by migration background and SES.

Published
2013
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6. Multimodal Treatment of Nasopharyngeal Carcinoma in Children, Adolescents and Young Adults-Extended Follow-Up of the NPC-2003-GPOH Study Cohort and Patients of the Interim Cohort

Author

Tristan Römer, Sabrina Franzen, Hanna Kravets, Ahmed Farrag, Anna Makowska, Hans Christiansen, Michael J. Eble, Beate Timmermann, Gundula Staatz, Felix M. Mottaghy, Martina Bührlen, Ulrich Hagenah, Alexander Puzik, Pablo Hernáiz Driever, Jeanette Greiner, Norbert Jorch, Stephan Tippelt, Dominik T. Schneider, Gabriele Kropshofer, Tobias R. Overbeck, Holger Christiansen, Triantafyllia Brozou, Gabriele Escherich, Martina Becker, Waltraud Friesenbichler, Tobias Feuchtinger, Wolfram Puppe, Nicole Heussen, Ralf D. Hilgers, Udo Kontny, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, Beeldvorming, RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health, and RS: Carim - B06 Imaging

Subjects
platin-based chemotherapy, young adults, Cancer Research, INTERFERON-BETA, nasopharyngeal carcinoma, ANTITUMOR-ACTIVITY, Medizin, MULTIPLE-SCLEROSIS, PHASE-2, DEPRESSION, INTENSITY-MODULATED RADIOTHERAPY, stomatognathic diseases, ADJUVANT CHEMOTHERAPY, Oncology, children, late toxicities, otorhinolaryngologic diseases, 5-FLUOROURACIL, TOLERABILITY, radiotherapy, interferon-beta, adolescents, PEMBROLIZUMAB
Abstract

Cancers 14(5), 1261 (2022). doi:10.3390/cancers14051261, Published by MDPI, Basel

Published
2022
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7. Diagnostik von Autismus- Spektrum-Störungen im Kindes-, Jugend- und Erwachsenenalter: Überblick zu den wesentlichen Fragestellungen und Ergebnissen des ersten Teils der S3-Leitlinie

Author

Leonora Vllasaliu, Ingo Spitzcok von Brisinski, Judith Sinzig, Luise Poustka, Helmut Hollmann, Diana Will, Ludger Tebartz van Elst, Inge Kamp-Becker, Kai Vogeley, Matthias Dose, Christine M. Freitag, Katrin Jensen, Claus Lechmann, and Ulrich Hagenah

Subjects
medicine.medical_specialty, 05 social sciences, General Medicine, Guideline, medicine.disease, language.human_language, 3. Good health, German, 03 medical and health sciences, Psychiatry and Mental health, Clinical Psychology, 0302 clinical medicine, Autism spectrum disorder, Pediatrics, Perinatology and Child Health, language, medicine, Key (cryptography), International Statistical Classification of Diseases and Related Health Problems, Early adolescents, 0501 psychology and cognitive sciences, Psychiatry, Psychology, 030217 neurology & neurosurgery, 050104 developmental & child psychology
Abstract

Zusammenfassung. Hintergrund: Autismus-Spektrum-Störungen (ASS) umfassen die ICD-10-Diagnosen (International Statistical Classification of Diseases and Related Health Problems) frühkindlicher Autismus, Asperger-Syndrom und atypischer Autismus und zeigen eine Lebenszeitprävalenz von bis zu 1 %. Die S3-Leitlinie der Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften e. V. hat zum Ziel, evidenzbasierte Diagnostik und Therapie für professionelle Akteure im Gesundheits- und Sozialsystem systematisch zusammenzufassen und klinische Empfehlungen zu konsentieren. Der vorliegende Artikel fasst die wesentlichen Ergebnisse zum Teil Diagnostik zusammen. Methodik: Die Leitliniengruppe besteht aus 14 klinischen und wissenschaftlichen Fachgesellschaften sowie Patienten-/Angehörigen-Vertretern. Die Empfehlungen basieren dabei auf den Ergebnissen systematischer Literatursuche, Datenextraktion, Studienqualitäts-Bewertung sowie metaanalytischer Datenaggregation in Kombination mit der klinischen Expertise der jeweiligen Vertreter. Die Empfehlungen wurden anhand eines nominalen Gruppenprozesses abgestimmt. Ergebnisse: Der aktuelle Forschungsstand zur Diagnostik wird zusammengefasst. Dabei liegt ein besonderer Schwerpunkt auf der Frage der Notwendigkeit und Entbehrlichkeit verschiedener Bestandteile des diagnostischen Prozesses. Nach einer allgemeinen Einführung zum Krankheitsbild werden insbesondere die wesentlichen Aspekte der Anamnese, die sinnvolle Verwendung von Screening- und Diagnostikinstrumenten, die internistisch-neurologische Untersuchung, apparative Diagnostik, testpsychologische Untersuchung, Aufklärung und Beratung sowie sinnvolle Verlaufsdiagnostik detailliert dargestellt. Schlussfolgerung: Die ASS-Leitlinie gibt evidenzbasierte, klinisch konsentierte Empfehlungen zum Prozess der Diagnostik von ASS im Kindes-, Jugend- und Erwachsenenalter. Sie bietet Anwendern zudem die Möglichkeit, sich in kurzer Zeit über die Hintergründe der Störung sowie verschiedene diagnostische Instrumente zu informieren.

Published
2019
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8. Webarchivierung in der SUB Hamburg: kleine Schritte in der Region – Bausteine zu einem größeren Ganzen?

Author

Ulrich Hagenah

Subjects
General Medicine
Abstract

Zusammenfassung Die Staats- und Universitätsbibliothek Hamburg sammelt im Rahmen ihres Auftrags als Landes- und Pflichtexemplarbibliothek seit 2015 Websites Hamburger Institutionen bzw. zu regional relevanten Themen. Der Beitrag beschreibt die rechtlichen und technischen Grundlagen, die Prinzipien der Auswahl, den Bearbeitungs-Workflow einschließlich der Katalogisierung sowie die Zugänge zu den Archivkopien der Websites. Diskutiert werden technisch-organisatorische Grenzen und der Stellenwert der Webarchivierung im landesbibliothekarischen Kontext.

Published
2017
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9. IFLA News Media Conference 'Reviving the past and keeping up with the future – the libraries’ role in preserving and providing access to newspapers and news media', Hamburg, Staats- und Universitätsbibliothek Carl von Ossietzky, 20-22 April 2016

Author

Mary Feeney and Ulrich Hagenah

Subjects
03 medical and health sciences, 0302 clinical medicine, 010504 meteorology & atmospheric sciences, Political science, Media studies, Library science, Library and Information Sciences, 01 natural sciences, 030217 neurology & neurosurgery, News media, 0105 earth and related environmental sciences, Newspaper
Published
2016
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10. Archivieren – aufbereiten – digitale Lebenswelten für die Forschung verfügbar halten: was können, was sollten Bibliotheken angesichts der Umwälzungen des Nachrichtenmarktes leisten?

Author

Ulrich Hagenah

Subjects
Political science, General Medicine, Humanities
Abstract

Zusammenfassung: Die IFLA News Media Section hat auf ihren Fachtagungen 2015 zunächst in Stockholm schwerpunktmäßig Beispiele für den bibliothekarischen Umgang mit originär digitalen Nachrichtenmedien und Websites in Pflichtexemplarsammlungen behandelt, bei der IFLA in Pretoria und Kapstadt dann vorrangig Probleme der Retrodigitalisierung von Zeitungen. Dabei stand die Situation im Süden Afrikas besonders im Mittelpunkt. Ferner werden verschiedene Aktivitäten zur Aufbereitung digitalen historischen Zeitungsmaterials zur weiteren Nutzung berichtet.

Published
2016
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11. Anorexia nervosa

Author

Almut Zeeck, Ulrich Cuntz, Beate Herpertz-Dahlmann, Stefan Ehrlich, Hans-Christoph Friederich, Gaby Resmark, Ulrich Hagenah, Verena Haas, Armin Hartmann, Martin Greetfeld, Stephan Zipfel, and Timo Brockmeyer

Published
2019
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15. Nachrichtenmedien im digitalen Wandel

Author

Ulrich Hagenah

Subjects
General Medicine
Abstract

Zusammenfassung: Für die IFLA Newspapers Section (künftig: News Media Section) hat sich mit der Retrodigitalisierung und der Entwicklung neuer digitaler Nachrichtenmedien das thematische Spektrum erheblich ausgeweitet. Fachtagungen 2014 behandelten u. a. digitale Pflichtexemplarsammlungen und neue Aufgaben der Bibliotheken bei Nachrichtenmedien, die Digitalisierung von Zeitungen, insbesondere das Europeana Newspapers Project, Nutzungsszenarien und Aktivitäten von Bibliotheken für attraktive, nutzerfreundliche Zugänge zu historischem Zeitungsmaterial. U. a. werden OCR-Verbesserung, Named Entity Recognition und automatisierte Linking-Verfahren als Wege zur Recherche-Optimierung für Zeitungen behandelt.

Published
2015
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16. Effects of a short-term reduction in brain serotonin synthesis on the availability of the soluble leptin receptor in healthy women

Author

Lothar Rink, C.S. Biskup, Florian D. Zepf, Sarah Bubenzer-Busch, K. Helmbold, Ulrich Hagenah, Jürgen Kratzsch, T. J. Gaber, Beate Herpertz-Dahlmann, V. L. S. Dingerkus, Albrecht Eisert, and Michael Schaab

Subjects
Adult, Leptin, Male, Serotonin, medicine.medical_specialty, Time Factors, Neurology, Cohort Studies, Young Adult, Double-Blind Method, Internal medicine, medicine, Humans, Young adult, Biological Psychiatry, Food, Formulated, Analysis of Variance, Leptin receptor, Tryptophan, Brain, Psychiatry and Mental health, Endocrinology, Receptors, Leptin, Female, Neurology (clinical), Analysis of variance, Psychology, Hormone
Abstract

Serotonin (5-HT) and the hormone leptin have been linked to the underlying neurobiology of appetite regulation with evidence coming from animal and cellular research, but direct evidence linking these two pathways in humans is lacking. We examined the effects of reduced brain 5-HT synthesis due to acute tryptophan depletion (ATD) on levels of soluble leptin receptor (sOb-R), the main high-affinity leptin binding protein, in healthy adults using an exploratory approach. Women, but not men, showed reduced sOb-R concentrations after ATD administration. With females showing reduced baseline levels of central 5-HT synthesis compared to males diminished brain 5-HT synthesis affected the leptin axis through the sOb-R in females, thereby potentially influencing their vulnerability to dysfunctional appetite regulation and co-morbid mood symptoms.

Published
2014
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17. Hämatologische Veränderungen bei Anorexia nervosa im Kindes- und Jugendalter

Author

Beate Herpertz-Dahlmann, Laura Vera Nanny Beate Gärtner, Jochen Seitz, Ulrich Hagenah, Katharina Bühren, and Lieven N. Kennes

Subjects
Gynecology, medicine.medical_specialty, medicine.diagnostic_test, business.industry, Blood count, Follow up studies, General Medicine, Hematocrit, Psychiatry and Mental health, Clinical Psychology, Anorexia nervosa (differential diagnoses), Pediatrics, Perinatology and Child Health, medicine, business, Body mass index
Abstract

Fragestellung: Hämatologische Veränderungen sind ein häufiges Phänomen der akuten Anorexia nervosa (AN). Dennoch ist der Zusammenhang mit klinischen Parametern noch unzureichend untersucht. Methodik: Bei 88 Patientinnen mit AN nach DSM-IV wurden bei stationärer Aufnahme und nach Gewichtsrehabilitation die Konzentration der Leukozyten, Erythrozyten und Thrombozyten, der Hämoglobingehalt, der Hämatokrit und ein Differenzialblutbild bestimmt und ein Zusammenhang mit verschiedenen klinischen Parametern untersucht. Ergebnisse: Bei Aufnahme zeigten sich milde Veränderungen der Blutwerte, die zumeist mit der Gewichtsrehabilitation reversibel waren. Patientinnen mit einem großen Gewichtsverlust vor Aufnahme und einem niedrigen altersadjustierten BMI sowie diejenigen, die Psychopharmaka einnahmen, hatten ein größeres Risiko, hämatologische Veränderungen aufzuweisen. Schlussfolgerungen: Auch wenn die hämatologischen Veränderungen bei jugendlichen Patientinnen mit AN zumeist milde sind, sollte bei Patientinnen mit niedrigem altersadjustiertem BMI und/oder ausgeprägter Gewichtsabnahme oder begleitenden Psychopharmakotherapie, auf ein sorgfältiges Monitoring des Blutbildes geachtet werden. Eine Veränderung der leukozytenabhängigen Immunantwort scheint bei erwachsenen chronifizierten Patientinnen zu einer gesteigerten Infektionsgefahr und damit einer erhöhten Mortalität beizutragen.

Published
2014
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18. Stationäre Therapie der adoleszenten Anorexia nervosa

Author

Beate Herpertz-Dahlmann, Katharina Bühren, and Ulrich Hagenah

Abstract

Der chronische Hungerzustand im Rahmen der Anorexia ­nervosa (AN) provoziert schwerwiegende somatische und psychische Folgen, die den normalen Entwicklungsprozess unterbrechen und ­gravierende Auswirkungen auf das Erwachsenenalter haben konnen. Eine fruhzeitige stationare Behandlung auf der Basis eines multi­modalen Konzepts gilt als Therapie der Wahl, um eine ausreichende Gewichts- und psychosoziale Rehabilitation zu erreichen und eine Chronifizierung der Storung zu vermeiden.

Published
2013
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19. Hamburg

Author

Ulrich Hagenah and Annett Helm

Subjects
General Medicine
Published
2013
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20. Olanzapine in Male and Female Adolescent Patients With Schizophrenia and Related Disorders

Author

Fritz Poustka, Martin H. Schmidt, Helmut Remschmidt, Eberhard Schulz, Anneliese Mästele, Ulrich Hagenah, Ralf W. Dittmann, Eberhard Meyer, Jenny Junghanss, Franz Joseph Freisleder, Michael Kluge, Michael Schulte-Markwort, Claudia Mehler-Wex, and Peter M. Wehmeier

Subjects
Olanzapine, medicine.medical_specialty, business.industry, Female adolescent, Minor (academic), Placebo, medicine.disease, Double blind, Psychiatry and Mental health, Schizophrenia, medicine, Haloperidol, Pharmacology (medical), Psychiatry, business, medicine.drug, Clinical psychology
Published
2010
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21. Pharmakotherapie bipolarer Störungen im Kindes- und Jugendalter

Author

Jennifer A. Vloet and Ulrich Hagenah

Subjects
Gynecology, medicine.medical_specialty, business.industry, General Medicine, medicine.disease, Psychiatry and Mental health, Clinical Psychology, Pharmacotherapy, Pediatrics, Perinatology and Child Health, medicine, Bipolar disorder, medicine.symptom, business, Mania
Abstract

Zusammenfassung: Hintergrund: Bipolare Störungen im Kindes- und Jugendalter sind seltene, aber ernste und oft zu weitreichenden Behinderungen in allen Lebensbereichen führende Erkrankungen. Im Zentrum der Behandlung steht die Pharmakotherapie, die über die Akutbehandlung hinaus meist mehrjährig als Rückfallprophylaxe fortgesetzt werden muss. Methodik: Durchgeführt wurde eine Medline-Recherche (Pubmed), mit der Suchstrategie: bipolar - mania - adolescents - early onset - pediatric onset - randomized - controlled trial - neuroleptics - antipsychotics - lithium - moodstabilizer. Ergebnisse: Trotz weit verbreiteter Anwendung von für das Erwachsenenalter etablierten Substanzen bei bipolar erkrankten Kindern und Jugendlichen existiert aktuell eine nur unzureichende Datenlage zur Wirksamkeit und Sicherheit der Anwendung in dieser Altersgruppe. Die Interpretation der Datenlage aus überwiegend offenen Studien wird durch die Kontroverse bezüglich der diagnostischen Validität bipolarer Störungen bei Kindern erschwert. Nebenwirkungen treten bei Kindern und Jugendlichen unter allen eingesetzten Substanzen häufiger und ausgeprägter auf als bei Erwachsenen und limitieren den Einsatz. Schlussfolgerungen: Auch wenn die vorliegenden Daten auf eine Wirksamkeit und ausreichende Verträglichkeit von atypischen Neuroleptika und Moodstabilizern in der Akutbehandlung von Kindern und Jugendlichen mit bipolarer Störung weisen, sind zusätzliche Placebo-kontrollierte Studien und Studien zur Langzeitbehandlung dringend erforderlich.

Published
2009
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22. Effectiveness and Tolerability of Olanzapine in the Treatment of Adolescents with Schizophrenia and Related Psychotic Disorders: Results from a Large, Prospective, Open-Label Study

Author

Fritz Poustka, Peter M. Wehmeier, Eberhard Schulz, Helmut Remschmidt, Eberhard Meyer, Anneliese Mästele, Claudia Mehler-Wex, Franz Joseph Freisleder, Michael Schulte-Markwort, Martin H. Schmidt, Ralf W. Dittmann, Jenny Junghanss, and Ulrich Hagenah

Subjects
Adult, Male, Olanzapine, medicine.medical_specialty, Adolescent, Weight Gain, Benzodiazepines, Electrocardiography, Open label study, Internal medicine, Brief Psychiatric Rating Scale, medicine, Humans, Pharmacology (medical), Prospective Studies, Child, Psychiatry, Adverse effect, Dose Modification, Electroencephalography, medicine.disease, Prolactin, Psychiatry and Mental health, Psychotic Disorders, Tolerability, Schizophrenia, Pediatrics, Perinatology and Child Health, Female, Psychology, Antipsychotic Agents, Psychopathology, medicine.drug
Abstract

The aim of this study was to assess effectiveness and tolerability of oral olanzapine treatment of adolescents with schizophrenic disorders.Adolescent patients (12-19 years) with schizophrenia, schizoaffective, or schizophreniform disorders according to the Diagnostic and Statistical Manual of Mental Disorders, 4(th) edition (DSM-IV) were enrolled in a multicenter, prospective, open-label study. Following a 2- to 9-day washout period, patients initially received 10 mg/day olanzapine. Dose modification was allowed during week 2 (dose range 5-15 mg/day) and during weeks 3-6 (dose range, 5-20 mg/day). Responders (improvementor =30% on the Brief Psychiatric Rating Scale, BPRS) continued olanzapine for additional 18 weeks. Psychopathology was assessed using BPRS and Clinical Global Impressions (CGI) scales; side effects were assessed by adverse event reporting.Out of 96 patients enrolled at 10 sites, 60 (62.5%) met response criteria at week 6. Mean BPRS total scores decreased significantly (p0.001) from baseline (39.2 +/- 13.4) to week 6 last observation carried forward (LOCF) (22.2 +/- 14.7). The rate of patients considered markedly ill or worse (CGI-S) decreased from 83.3% (baseline) to 37.5% (week 6, LOCF). The most common reported adverse event was weight gain (30.2%, 29/96). Three patients (3.1%) discontinued due to adverse events.In this study of young patients with schizophrenia, schizoaffective, or schizophreniform disorders, olanzapine treatment was associated with marked symptom improvement. As changes in weight and prolactin levels may be greater in adolescent than in adult patients, potential risks and benefits of olanzapine treatment in adolescents should be considered carefully.

Published
2008
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23. Schlafstörungen bei kinder- und jugendpsychiatrischen Erkrankungen

Author

Ulrich Hagenah

Subjects
medicine.medical_specialty, Sleep disorder, business.industry, General Medicine, medicine.disease, Comorbidity, Tourette syndrome, Psychiatry and Mental health, Clinical Psychology, Kleine–Levin syndrome, Pediatrics, Perinatology and Child Health, Child and adolescent psychiatry, medicine, Insomnia, Autism, medicine.symptom, Psychiatry, business, Narcolepsy
Abstract

Zusammenfassung: Schlafstörungen als Symptom zahlreicher kinder- und jugendpsychiatrischer Störungsbilder komplizieren häufig den Verlauf und die Behandlung der Grunderkrankung. Organische Störungen wie die Narkolepsie oder das Kleine-Levin-Syndrom können zu differentialdiagnostischen Schwierigkeiten und Fehleinschätzungen führen. Unklar ist, ob spezifische Veränderungen der Schlafarchitektur bereits im Kindes- und Jugendalter bestehen und damit als biologischer Trait-Marker für psychiatrische Erkrankungen zu verstehen sind. Während für das Erwachsenenalter die Bedeutung von Schlafstörungen vor allem für die Entwicklung späterer depressiver Störungen belegt werden konnte, ist derzeit offen, ob es sich bei persistierenden Schlafstörungen im Kindesalter um Vulnerabilitätsmarker für psychiatrische Erkrankungen handelt. In der vorliegenden Literaturübersicht sollen Wechselwirkungen zwischen Schlafstörung und psychischer Störung aufgezeigt und die Bedeutung der Berücksichtigung von Schlafstörungen für Diagnostik und Therapie kinder- und jugendpsychiatrischer Störungsbilder unterstrichen werden.

Published
2002
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24. Tuberöse Sklerose und organische bipolare Störung bei einer 15jährigen Jugendlichen

Author

H. Coners, Ulrich Hagenah, Beate Herpertz-Dahlmann, and F. Kotlarek

Subjects
Gynecology, Psychiatry and Mental health, Clinical Psychology, medicine.medical_specialty, business.industry, Pediatrics, Perinatology and Child Health, medicine, General Medicine, business, Organic mood disorder
Abstract

Zusammenfassung: Wir berichten über eine Patientin mit tuberöser Sklerose, die im Alter von 15 Jahren unter antiepileptischer Medikation mit Oxcarbazepin mehrere rasch wechselnde Episoden (rapid cycling) einer bipolaren Erkrankung entwickelte. Eine Kombinationsbehandlung mit Oxcarbazepin und Valproat bei in dieser Phase erstmals auftretenden Grand-mal-Anfällen erwies sich als nicht ausreichend zur Prophylaxe der affektiven Symptomatik. Eine wesentliche Stabilisierung des klinischen Bildes erfolgte unter zusätzlicher, niedrig dosierter Lithium-Einstellung, die durch wiederholt auftretende Hyperkaliämien erschwert wurde.

Published
1999
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26. Day-patient treatment after short inpatient care versus continued inpatient treatment in adolescents with anorexia nervosa (ANDI): a multicentre, randomised, open-label, non-inferiority trial

Author

Katharina Bühren, Reinhild Schwarte, Beate Herpertz-Dahlmann, Andreas Warnke, Karin Egberts, Ulrike Schmidt, Ernst Pfeiffer, André Scherag, Astrid Dempfle, Kerstin Konrad, Christian Fleischhaker, Melanie Krei, Christoph Wewetzer, Carmen Schade-Brittinger, Nina Timmesfeld, Kristian Holtkamp, and Ulrich Hagenah

Subjects
Pediatrics, medicine.medical_specialty, Anorexia Nervosa, Adolescent, Cost-Benefit Analysis, MEDLINE, Medizin, Day care, law.invention, Body Mass Index, Patient safety, Randomized controlled trial, law, Recurrence, Germany, Medicine, Humans, Child, Analysis of Variance, Intention-to-treat analysis, Inpatient care, business.industry, General Medicine, Hospitalization, Treatment Outcome, Anorexia nervosa (differential diagnoses), Female, Patient Safety, business, Body mass index, Day Care, Medical
Abstract

In-patient treatment (IP) is the treatment setting of choice for moderately-to-severely ill adolescents with anorexia nervosa, but it is costly, and the risks of relapse and readmissions are high. Day patient treatment (DP) is less expensive and might avoid problems of relapse and readmission by easing the transition from hospital to home. We investigated the safety and efficacy of DP after short inpatient care compared with continued IP.For this multicentre, randomised, open-label, non-inferiority trial, we enrolled female patients (aged 11-18 years) with anorexia nervosa from six centres in Germany. Patients were eligible if they had a body-mass index (BMI) below the tenth percentile and it was their first admission to hospital for anorexia nervosa. We used a computer-generated randomisation sequence to randomly assign patients to continued IP or DP after 3 weeks of inpatient care (1:1; stratified for age and BMI at admission). The treatment programme and treatment intensity in both study groups were identical. The primary outcome was the increase in BMI between the time of admission and a 12-month follow-up adjusted for age and duration of illness (non-inferiority margin of 0·75 kg/m(2)). Analysis was done by modified intention to treat. This trial is registered with the International Standard Randomised Controlled Trial Number Register, number ISRCTN67783402, and the Deutsches Register Klinischer Studien, number DRKS00000101.Between Feb 2, 2007, to April 27, 2010, we screened 660 patients for eligibility, 172 of whom we randomly allocated to treatment: 85 to IP and 87 to DP. DP was non-inferior to IP with respect to the primary outcome, BMI at the 12-month follow-up (mean difference 0·46 kg/m(2) in favour of DP (95% CI, -0·11 to 1·02; pnon-inferiority0·0001). The number of treatment-related serious adverse events was similar in both study groups (eight in the IP group, seven in the DP group). Three serious adverse events in the IP group and two in the DP group were related to suicidal ideation; one patient in the DP attempted suicide 3 months after she was discharged.DP after short inpatient care in adolescent patients with non-chronic anorexia nervosa seems no less effective than IP for weight restoration and maintenance during the first year after admission. Thus, DP might be a safe and less costly alternative to IP. Our results justify the broad implementation of this approach.German Ministry for Education and Research.

Published
2014

27. [Hematological changes in adolescent anorexia nervosa]

Author

Katharina, Bühren, Laura, Gärtner, Lieven N, Kennes, Jochen, Seitz, Ulrich, Hagenah, and Beate, Herpertz-Dahlmann

Subjects
Psychotropic Drugs, Anorexia Nervosa, Adolescent, Platelet Count, Weight Gain, Body Mass Index, Leukocyte Count, Young Adult, Hematocrit, Acute Disease, Erythrocyte Count, Hemoglobinometry, Humans, Female, Child, Follow-Up Studies, Retrospective Studies
Abstract

Hematological changes often occur in patients with acute anorexia nervosa (AN). However, the relationship between these disturbances and other clinical parameters remains unclear.Leucocyte, erythrocyte, and thrombocyte counts as well as hematocrit, hemoglobin, and differential blood counts were collected at admission and after weight restoration in 88 female adolescent patients with the diagnosis of AN according to DSM-IV. These were then compared to clinical parameters.At admission, there were mild changes in the blood count, most of which, however, were reversible after weight gain. Patients with a greater weight loss, a lower age-adjusted BMI, and a history of taking psychotropic drugs were more likely to develop hematological abnormalities.Although most of the hematological changes in adolescent patients with AN were mild, patients with high weight loss and/or low age-adjusted BMI as well as those on psychotropic medication should be monitored carefully in order to avoid severe medical complications. An altered immune function in adult patients with chronic AN might contribute to a higher rate of infections and thus to an increased mortality.Fragestellung: Hämatologische Veränderungen sind ein häufiges Phänomen der akuten Anorexia nervosa (AN). Dennoch ist der Zusammenhang mit klinischen Parametern noch unzureichend untersucht. Methodik: Bei 88 Patientinnen mit AN nach DSM-IV wurden bei stationärer Aufnahme und nach Gewichtsrehabilitation die Konzentration der Leukozyten, Erythrozyten und Thrombozyten, der Hämoglobingehalt, der Hämatokrit und ein Differenzialblutbild bestimmt und ein Zusammenhang mit verschiedenen klinischen Parametern untersucht. Ergebnisse: Bei Aufnahme zeigten sich milde Veränderungen der Blutwerte, die zumeist mit der Gewichtsrehabilitation reversibel waren. Patientinnen mit einem großen Gewichtsverlust vor Aufnahme und einem niedrigen altersadjustierten BMI sowie diejenigen, die Psychopharmaka einnahmen, hatten ein größeres Risiko, hämatologische Veränderungen aufzuweisen. Schlussfolgerungen: Auch wenn die hämatologischen Veränderungen bei jugendlichen Patientinnen mit AN zumeist milde sind, sollte bei Patientinnen mit niedrigem altersadjustiertem BMI und/oder ausgeprägter Gewichtsabnahme oder begleitenden Psychopharmakotherapie, auf ein sorgfältiges Monitoring des Blutbildes geachtet werden. Eine Veränderung der leukozytenabhängigen Immunantwort scheint bei erwachsenen chronifizierten Patientinnen zu einer gesteigerten Infektionsgefahr und damit einer erhöhten Mortalität beizutragen.

Published
2013

28. Self-perceived stigmatization in female patients with anorexia nervosa--results from an explorative retrospective pilot study of adolescents

Author

Dominik Gross, S. Müller, Beate Herpertz-Dahlmann, Florian D. Zepf, A. Maier, Ulrich Hagenah, and J.-P. Ernst

Subjects
medicine.medical_specialty, Stereotyping, Anorexia Nervosa, Time Factors, Adolescent, Stigma (botany), Pilot Projects, Mental illness, medicine.disease, Self Concept, Psychiatry and Mental health, Clinical Psychology, Young Adult, Anorexia nervosa (differential diagnoses), Surveys and Questionnaires, Female patient, medicine, Self perceived, Humans, Female, Psychiatry, Psychology, Clinical psychology, Retrospective Studies
Abstract

Background: The stigma of mental illness has been identified as an important barrier to treatment and recovery. Previous research reported the stigmatization of individuals with eating disorders by both health professionals and the general public. The aim of this pilot study was to empirically assess the previous stigmatization and discrimination experiences of young female patients with anorexia nervosa (AN) using a retrospective explorative approach. Methods: An in-house questionnaire that was developed to survey experiences of stigmatization was mailed to 75 former adolescent patients with AN. The mean time of assessment after discharge was 5.6 ± 1.2 years. The patients were asked to respond anonymously. The response rate was approximately 48% (n = 36). Results: Feelings that society held negative stereotypes of individuals with AN, concrete experiences of stigmatization and discrimination, and rejection by peers were reported. A remarkable degree of self-stigmatization, as indexed by high rates of agreement to stigmatizing statements, was detected. Approximately one third of the participants reported delayed initiation of treatment due to fear of stigmatization and discrimination. Conclusion: Stigmatization plays a decisive role in young patients with AN and impacts their motivation to seek professional help and engage in treatment. Clinicians should be aware of the stigmatization related to eating disorders and its burden for affected patients.

Published
2012

29. The Diagnosis and Treatment of Eating Disorders

Author

Stephan, Herpertz, Ulrich, Hagenah, Silja, Vocks, Jörn, von Wietersheim, Ulrich, Cuntz, Almut, Zeeck, and Martina, de Zwaan

Subjects
medicine.medical_specialty, Cognitive Behavioral Therapy, Binge eating, business.industry, Bulimia nervosa, Clinical Practice Guideline, General Medicine, medicine.disease, Anorexia nervosa, Feeding and Eating Disorders, Psychotherapy, Eating disorders, Binge-eating disorder, Weight loss, Practice Guidelines as Topic, medicine, Humans, medicine.symptom, Overeating, business, Psychiatry, Body mass index, Selective Serotonin Reuptake Inhibitors
Abstract

The main symptom of anorexia nervosa (AN) is self-induced malnutrition with weight loss that may amount to cachexia. According to the diagnostic criteria, the body weight is so low that health impairment is to be feared. In adults, this danger is seen when the body mass index (BMI) drops below 17.5kg/m2; in children and adolescents, it corresponds to being below the 10th BMI-for-age percentile. Since children have a much smaller fat mass than adults or adolescents, the somatic sequelae of starving during AN occurring early in life are more serious and have negative consequences for, e.g., bone density, growth in height, and cerebral maturation. AN is often accompanied by other psychological illnesses such as depression, anxiety, or compulsive disorder. The average frequency of AN in young women aged between 14 and 20 years varies between 0.2% and 0.8% (1) (eBox 1). eBox 1 ICD-10 diagnostic criteria for anorexia nervosa (F 50.0) (2) Actual body weight at least 15% below expected weight, or body mass index 17.5 or less (in adults). Weight loss is caused by the avoidance of high-calorie foods and at least one of the following: Self-induced vomiting Self-induced purging Excessive exercise Use of appetite suppressants and/or diuretics Distorted body image as a specific psychological disorder Endocrine disorder, manifest in the female as amenorrhea and in the male as a loss of libido If onset is prepubertal, the puberty in boys and girls may be delayed (growth ceases; in girls the breasts do not develop) The 10-year mortality in this group is around 5%. This is considerably more than 10 times the mortality from other causes in this age group in the general population (1, 2). Follow-up studies have shown that around 40% of patients with AN show good treatment success, while 25% have moderate and 30% poor treatment success (3). The term “bulimia nervosa” (BN) refers to the uncontrollable urge for frequent high-calorie food. Episodes of excessive uncontrolled eating alternate with rigorous fasting, vomiting, and abuse of laxatives and/or diuretics. At 2%, BN has a notably higher prevalence than AN. Both of these eating disorders affect women in the large majority of cases; men are affected in only 5% to 10% of cases (1) (eBox 2). eBox 2 ICD-10 diagnostic criteria for bulimia nervosa (F 50.2) (2) The constant obsession with eating and the overwhelming desire for food leads to episodes of eating large amounts of food in short time periods. There are efforts made to reduce the effect of eating foods perceived as fattening in the form of self-induced vomiting and other purging techniques, alternating episodes of calorie restriction, using appetite suppressants, thyroid preparations or diuretics. People with diabetes may refrain from using their insulin treatment. There is an intense fear of becoming fat, which leads to the desire to reach a specific body weight much lower than is considered normal or healthy for height and age. In many cases, the bulimia follows an episode of anorexia nervosa, although the period of time between the two disorders may vary considerably. According to studies in the USA, about 50% of patients with BN are free of symptoms after more than 5 years, while about 20% continue to fulfill all the criteria of the disorder (4). The diagnosis “binge eating disorder” (BED) was incorporated by the American Psychiatric Association in the fourth revision of the Diagnostic and Statistic Manual of Mental Disorders (DSM-IV) in 1994 (5); in the International Classification of Diseases (ICD-10) it can only be coded under the category “eating disorder, unspecified” (F50.9). The course of BED has been the object of less research than AN and BN, but its prognosis is better. Remission rates in outpatient psychotherapy range between 50% and 80% (5– 7) (eBox 3). eBox 3 Diagnostic criteria for binge eating disorder (7) Recurring episodes of binge eating. The two characteristics of a binge eating episode are: Eating a much larger amount of food than most people would consider normal under similar circumstances and within the same time frame (eating may continue for several hours). While eating, there is a feeling of loss of control over the amount of food or type of food being consumed. Binge eating episodes are related to at least three of the following: Eating until feeling uncomfortably full. Eating large quantities of food when not even hungry. Eating noticeably faster than is considered normal. Eating alone due to embarrassment of overeating. Feelings of disgust, depression, or guilt after a binge. There is obvious distress concerning binge eating behavior. On average, binge eating takes place twice weekly, and has done so for 6 months. There are no recurring efforts to compensate for binge eating, such as purging or excessive exercise. The disorder occurs at times other than during episodes of anorexia nervosa or bulimia nervosa. The prevalence of BED varies in the general population between 0.7% (8) and 4.3% (9); women are affected about 1.5 times as often as men (10). The eating disorders AN and BN are of great social significance because they almost exclusively affect young people—with serious consequences for their physical and mental health. Overall, eating disorders give rise to enormous direct and indirect costs. Costs of 5300 EUR for AN and 1300 EUR for BN per patient per year are to be expected. Haas et al. (11) calculated an average of 4647 EUR in inpatient costs per patient. Krauth et al. (12) calculated overall costs of 12 800 EUR for a patient with AN. These costs are way above the average costs for inpatients with other diseases. So far as the authors know, no cost analyses have yet been done for BED.

Published
2011
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30. Diagnostik von Essstörungen

Author

Ulrich Hagenah, Brunna Tuschen-Caffier, Ulrich Schweiger, and Harriet Salbach-Andrae

Abstract

Im allgemeinarztlichen Setting sollte bei folgenden Risikofaktoren an eine Essstorung gedacht werden (KKP): junge Frauen mit niedrigem Korpergewicht, Patientinnen, die mit Gewichtssorgen kommen, aber nicht ubergewichtig sind, Frauen mit Zyklusstorungen oder Amenorrhoe, Patientinnen, die mangelernahrt erscheinen, Patientinnen mit gastrointestinalen Symptomen, Patientinnen mit wiederholtem Erbrechen, Kinder mit Wachstumsverzogerung.

Published
2011
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31. Die therapeutische Beziehung zu Patientinnen mit der Diagnose einer Essstörung

Author

Burkard Jäger, Stephan Herpertz, Harriet Salbach-Andrae, Brunna Tuschen-Caffier, and Ulrich Hagenah

Abstract

Patientinnen mit der Diagnose einer Essstorung sind zum Zeitpunkt der Suche nach einer psychotherapeutischen Behandlung oder Erstvorstellung zumeist ambivalent hinsichtlich der Veranderung ihrer Essprobleme (z. B. Normalisierung ihres Essverhaltens vs. restriktives Essverhalten, um das Korpergewicht niedrig zu halten). Auch die Bereitschaft, mit der Essstorung einhergehende Gedanken und Gefuhle offen zum Ausdruck zu bringen, ist zu Beginn der Behandlung – und zum Teil auch im gesamten Therapieprozess – ambivalent oder sogar gering ausgepragt (z. B. kann es einer Patientin mit AN schwerfallen, ihren Stolz uber ihr niedriges Korpergewicht zu thematisieren).

Published
2011
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33. Anorexia nervosa

Author

Almut Zeeck, Ulrich Cuntz, Armin Hartmann, Ulrich Hagenah, Hans-Christoph Friederich, Gaby Gross, Kristian Holtkamp, and Stephan Zipfel

Published
2011
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35. Binge-Eating-Störung

Author

Silja Vocks, Reinhard Pietrowsky, Brunna Tuschen-Caffier, Anette Kersting, Ulrich Hagenah, Harriet Salbach-Andrae, and Stephan Herpertz

Published
2011
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38. Autorinnen und Autoren

Author

Michael Beck, Frank Berthold, Ralf Bialek, Uta Bierbach, Michael Borte, Ulrich Brandl, Reiner Buchhorn, Guido Bürk, Stefan Burdach, Martin Burdelski, Marcus Dahlheim, Uta Dirksen, Jörg Dötsch, Walter Dorsch, Stefan Eber, Andreas Eicken, Lars Fischer, Jürgen Föll, Reiner Frank, Franz Joseph, Hans Peter, Ulrich Göbel, Norbert Graf, Bodo Grimbacher, Andreas Groll, Ulrich Hagenah, Ulrich Heininger, Alexander Hemprich, Barbara Hero, Beate Herpertz-Dahlmann, Egbert Herting, Gabriele Hessling, Olaf Hiort, Ulrich Hofmann, Hans-Iko Huppertz, Heribert Jürgens, Thomas Michael Kapellen, Matthias Kappler, Thomas Klingebiel, Gerhard Kluger, Ina Knerr, Dieter Körholz, Ewa Koscielniak, Christof Kramm, Martina Krauss-Haas, Joachim Kreuder, Anne Krümpel, Manfred Kudernatsch, Christiane Lex, Hermann Lindemann, Ulrike Lükewille, Esther M. Maier, Karl Mantel, Christine Mauz-Körholz, Otto Mehls, Andreas Merkenschlager, Ulrich Merz, Ania Carolina Muntau, Heidrun Müller, Thomas Müller, Wolfgang Müller-Felber, Erika von Mutius, Petra Nickel, Thomas Nicolai, Tim Niehues, Gerhard Niemann, Charlotte M. Niemeyer, Michele Noterdaeme, Ulrike Nowak-Göttl, Christina Ortmann, Karl P. Paul, Thomas Paul, Roland Pfäffle, Christian Plank, Christian F. Poets, Raymund Pothmann, Torsten Prietzel, Klemens Raile, Vera Raile, Wolfgang Rascher, Paul Reinhold, Ellen Renner, Annette Richter-Unruh, Joachim Roesler, Holger Römpler, Bernhard Roth, Andreas Schaper, Dieter Schlamp, Achim A. Schmaltz, Heinrich Schmidt, Eckhard Schönau, Torsten Schöneberg, Martin Schöning, Dietmar Schranz, Ingram Schulze-Neick, Volker Schuster, Dietrich von Schweinitz, Nicolaus Schwerk, Konrad Seller, Oliver Semler, Werner Siekmeyer, Thorsten Simon, Stephan Springer, Ina Sterker, Michael Sticherling, Rainer Strotmann, Anke Süß, Edelhard Thoms, Holm Uhlig, Kurt Ullrich, Hans Versmold, Katharina Vezyroglou, Isolde Wachter, Bettina Westhoff, Regina Wieland, Alexander Wild, Helmut Willgerodt, Magdalena Wojan, Johannes Wolff, and Elke Wühl

Published
2007
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39. Jugendalter

Author

Edelhard Thoms, Beate Herpertz-Dahlmann, Vera Raile, Ulrich Hagenah, and Petra Nickel

Subjects
business.industry, Medicine, business
Published
2007
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40. Group psychoeducation for parents of adolescents with eating disorders: the Aachen program

Author

Kristian Holtkamp, Beate Herpertz-Dahlmann, Timo D. Vloet, and Ulrich Hagenah

Subjects
Coping (psychology), medicine.medical_specialty, medicine.medical_treatment, General Medicine, medicine.disease, Psychiatry and Mental health, Clinical Psychology, Eating disorders, Psychoeducation, medicine, Multimodal treatment, Psychiatry, Psychology, Clinical psychology
Abstract

Family-based treatment in adolescents and individual psychoeducation in adults are accepted components in a multimodal treatment of eating disorders. However, only few studies have been conducted on the use of parent-based psychoeducation. This paper presents the structure and content, as well as a preliminary evaluation, of a group psychoeducation program for parents of adolescent patients with eating disorders. The program is limited to five 90-minute sessions and aimed at increasing the parents’ understanding of the disorder and promoting high transparency with regard to our treatment principles. The vast majority of parents rated the group psychoeducation as helpful in coping with their child's disorder and would recommend others to take part in the program. This work was supported by a grant of the Christina Barc Foundation (Essen, Germany).

Published
2006

41. [Adolescent eating disorders]

Author

Beate, Herpertz-Dahlmann, Ulrich, Hagenah, Timo, Vloet, and Kristian, Holtkamp

Subjects
Adult, Patient Care Team, Anorexia Nervosa, Adolescent, Mental Disorders, Comorbidity, Combined Modality Therapy, Treatment Outcome, Risk Factors, Practice Guidelines as Topic, Humans, Female, Bulimia, Child
Abstract

Anorexia and Bulimia nervosa are common psychiatric disorders in adolescent girls. In discrepancy to ICD-10 and DSM-IV we would propose the 10th BMI percentile as weight criterium for anorexia nervosa. Both disorders have a high somatic and psychiatric comorbidity; the most severe complication at long term follow-up is osteoporosis. The most prevalent psychiatric disorders are affective disorders, anxiety and obsessive-compulsive disorder and substance abuse. There is undoubtedly a genetic predisposition and a range of general and personal environmental risk factors. Treatment of adolescent eating disorders mostly requires a multimodal approach which consists of several components, e.g. weight rehabilitation, nutritional counselling, individual and family psychotherapy, and treatment of comorbid psychiatric disorders.

Published
2005

42. Symposia

Author

Christoph Correll, Stanley P. Kutcher, John McClellan, Jan Buitelaar, Elizabeth Pappadopulos, Aribert Rothenberger, Fritz Mattejat, Stephen Scott, John Weisz, Eberhard Schulz, Wilhelm Felder, Christian Fleischhaker, R. Böhme, B. Sixt, Rutger Jan van der Gaag, Laurence Y. Katz, Brian J. Cox, Shiny Gunasekara, Alec L. Miller, Nathaniel Laor, Peter Riedesser, Ernesto Caffo, James Leckman, Massimo Ammaniti, Giampaolo Nicolais, Mario Speranza, Hans Steiner, Laura Delizonna, Astrid Schallauer, Margo Thienemann, Alexander C. McFarlane, Miranda van Hooff, Michael Sawyer, Carlo Cianchetti, Naoufel Gaddour, Mokni Sana, Mechri Anouar, Letaief Mondher, Gaha Lotfi, Fabian Härtling, Robert Bittner, Corinna Haenschel, Marcus Cap, Tanja Goncharova, David E. J. Linden, Ralf Dittmann, Anneliese Maestele, Claudia Mehler, Eberhard Meyer, Jack A. Jenner, Leonie Boeing, Val Murray, Anthony Pelosi, Robert McCabe, Douglas Blackwood, Robert Wrate, S. Pellerano, M. Pintor, G. L. Mellis, T. Piroddi, Alan Flisher, Monique Nesa, Rosanna Rooney, Clare Roberts, Robert Kane, Sven Silburn, Lisbeth Pike, Helge Staby Deaton, Stuart Lustig, Michelle Funk, Anne Rickards, Dinah Reddihough, Roslyn Wright-Rossi, Jacqui Simpson, Dieter David Seuthe, H. Vielhaber, Kinderklinik Dritter Orden, H. Backmund, M. Gerlinghoff, Mary Schwab-Stone, Ine Jespers, Robert Vermeiren, Vladislav Ruchkin, Marek Blatny, Michal Hrdlicka, Tomas Urbanek, Martin Jelinek, Veronika Balastikova, Philippe Jeammet, Alain Frottin, Andjelka Filipovic, Eric Albert, Dora Musetti Schelotto, Mladen Knezevic, Milivoj Jovancevic, Jonathan Hill, Maria Lawlor, Christian Kienbacher, Carolin Prause, Margit Stöckl, Gertrude Bogyi, Max H. Friedrich, Michael Klein, Katrin Kürschner, Lynne Murray, Victoria Leidecker, Helen Sharp, Ilona Luoma, Pälvi Kaukonen, Tuula Tamminen, Barry Nurcombe, Graham Martin, Brett McDermott, Franz Resch, Benno Graf Schimmelman, Jane Edwards, Patrick D. McGorry, Martin Lambert, Philippe Conus, Ulrich Preuss, Dieter Bürgin, Monika Strauss, Peter Parzer, Georg Spiel, C. von Korff, H.-A. Ballin, R. Gößler, M. Günter, G. Sange, Heiner Meng, Eginhard Koch, Klaus Minde, Mary True, L. Pisani, F. Oumar, J. Padilla, Jean-François Bouville, Wendy Vogel, Klaus Schmeck, Kirstin Goth, Diane Purper-Ouakil, Véronique Dessons, Catherine Doyen, Fernando Perez-Diaz, Marie-Christine Mouren-Simeoni, Andreas Karwautz, Gudrun Wagner, Klaus Schwienbacher, Maria Haidvogl, Gerald Nobis, Janet Linda Treasure, David Andrew Collier, Romuald Brunner, A. Hueg, Johann Haffner, Marc Schmid, Lutz Goldbeck, Jakob Nützel, Volkmar Höfling, Karin Schermelleh-Engel, Helfried Moosbrugger, Josep Tomàs, Josep Cornellà, Alex Llusent, Anna Bielsa, Myron Belfer, Brian Robertson, Custodia Mandlhate, Birama Seck, Barbara Zwirs, Huib Burger, Tom Schulpen, A. Karem Salman Al-Obedy, Oleh Romanchuk, Irena Namyslowska, Björn S. Reigstad, Kirsti Margrethe Jorgensen, Walter Matthys, John Lochman, Marjo Zonnevylle-Bender, Nicolle van de Wiel, Angela Wagner, Christine Jennen-Steinmetz, Christopher Goepel, Irene van Bokhoven, Stephanie van Goozen, L. Patt Franciosi, Leode Graaf Acquoy, Anne Tischlinger, B. Pharm, Knut Halyard Bronder, Kari Schleimer, Joachim Walter, Boia Ephraime, Tatjana Dmitrieva, Alvaro Seligman Silva, Katja Becker, Hans-Christoph Steinhausen, C. Winkler Metzke, Erikson F. Furtado, Manfred Laucht, Oliver Bilke, Petra Zimmermann, Hans-Ulrich Wittchen, Roselind Lieb, Helga Hannesdottir, Thorarinn Tyrfingsson, Manfred Döpfner, Kurt Hahlweg, Annett Kuschel, Heike Bertram, Nina Heinrichs, Inez Freund-Braier, Gabriele Brix, Christopher Hautmann, Julia Pluck, Alfons Crijnen, Pol van Lier, Patricia Vuijk, Reiner Frank, Inger Helene Vandvik, Rainer Schäfert, Jeanne van Weel, Jan Schieveld, Jörg M. Fegert, William Friedrich, Smadar Celestin-Westreich, Leon Patrice Celestin, Ingrid Ponjaert-Kristoffersen, Keizo Nagao, M. Kisida, E. Shindo, Helmer Baying Larsen, Karin Helweg-Larsen, Ramón Lindauer, Jan Booij, Miranda Olff, Gerard den Heeten, Berthold Gersons, Frits Boer, Eric Schoentjes, Sarah Bal, Michael Schulte-Markwort, Tytti Solantaus, Sini Toikka, Maarit Alasuutari, Barbara Steck, Andrea Grether, M. Ehrensperger, Felix Amsler, L. Kappos, Rina Saha, Bela Paschen, Christiane Baldus, Miriam Haagen, Martina Pott, Georg Romer, Yoshiro Ono, H. Homma, Y. Ishida, H. Ide, M. Okamoto, S. Kameoka, Hiroshi Nakayama, A. Yamamoto, Nahit Motavalli Mukaddes, Sam Tyano, Tamar Mozes, R. Caplan, Savita Malhotra, Maria Giuseppina Ledda, Al Fratta, S. Mannino, Simona Corona, A. Zuddas, Macarena Marin Olalla, Ruth Garcia, Bernardo Perez Ramirez, Ross Campion, Peter Hindley, Nitin Gupta, Anish Bhattacharaya, Mehak Kapoor, G. van de Willge, Silke Klemm, S. Smesny, M. Stockebrand, S. Grunwald, Femmie Juffer, Marinus H. van Ijzendoorn, Marian J. Bakermans-Kranenburg, Ute Ziegenhain, B. Derksen, R. Dreisörner, Daniel Gutschner, Martin Maldonado-Duran, Manuel Ferndndez-Criado, Felicia Heidenreich, Marie Rose Moro, Charles Millhuff, Kirby Pope, Frank Theisen, Hubertus Himmerich, T. Kraus, A. Schuld, T. Pollmächter, Alan Apter, D. Gothelf, A. Brand-Gothelf, Gidi Ratzoni, L. Kikinzon, A. Weizman, Yuval Bloch, Michael Haberhausen, Daniel Müller, John Fayyad, Altino Bessa Marques Filho, Adolfo Bezerra de Menezes, John Campo, Sheree Shafer, Jennifer Strohm, Amanda Lucas, David Shaeffer, Harold Altman, Christine Gelachek, Naoyasu Motomura, Yozo Takino, Masahiro Iwakiri, Patrick Pössel, Simone Seemann, Martin Hautzinger, Theodore Mutale, Christian Haase, Majid Ali Abidi, Shehla Raheem, Leyla Faw, Aaron Hogue, Howard Liddle, Kirsten Catthoor, Joost Hutsebaut, Donald Jasinski, Douglas Faries, Rodney Moore, Annette Streeck-Fischer, Renate Sannwald, Gottfried Maria Barth, Christoph Schwarz, Monika Staigle, Manh-Hiep Pham, Dario Balanzin, Joelle Materi, Pia Eresund, Alexander Mokhovikov, Sandra Stankovic, Kerim Munir, Nese Erol, Füsun Çuhadarodlu Çetin, Angela Hassiotis, Martine Flament, Michael Scholz, Maud Rix, Franziska Nestler, Annegret Selisko, Nathalie Godart, Fabienne Perdereau, Zoé Rein, Florence Curt, Jane Akister, Pei-Chin Peggy Lee, Sho-Man Susan Tsai, Lai-Shiun Ho, Su-Chun Wu, Jacques Miermont, Joel Swenson, Mardjane Teherani, Bruno Falissard, Jean Cottraux, Julia Plück, Robert Oades, Mirjam Simons-Sprong, P. F. Schothorst, J. T. Swaab-Barneveld, Stephanie Juran, Matthias Weisbrod, Eric Chen, Bernd Röpcke, Smiljka Popovic-Deusic, Luise Poustka, Nele Wild-Wall, Mechthilde Papousek, Mirelle Keren, Ruth Feldman, S. Maestro, A. Chilosi, C. Pecini, L. Pfanner, Laurence Greenhill, K. Jahnsen, L. T. W. Jong-van den Berg, J. M. Zito, Kelly Posner, Anne Skrobala, Pablo Goldberg, Lisa Kotler, Robert Findling, Regina Bussing, Kapil Sayal, Geoffrey Mitchell, Michael Huss, Barbara Högl, Renate Grimmlinger, Karl Christoph Käppler, Maycoln M. L. Teodoro, Sylvia Hiromi Oswald, Janine M. Dagnoni, M. I. Pinheiro, C. T. Heleno, R. Rothe-Neves, V. G. Haase, A. Del Prette, Marimilia Rodrigues Lambertucci, J. L. Rodrigues, P. M. Freitas, C. A. P. Lourenco, H. C. W. Carvalho, J. Baumeister, M. Weisenhorn, S. Stadelmann, S. H. Oswald, H. Ruder, Ciro Ruggerini, Stefania Vicini, Enrico Pupulin, Antonio Guidi, Kaija Puura, Mirjami Mäntymaa, Kai von Klitzing, Orna Rosvald, Hans-Ludwig Kröber, A. Stöver, R. Proske, Rainer Semmelbeck, Marc Walther, Matthias Schmelzle, Monika Egli-Alge, Richard Beckett, Constanze Gerhold, Lieselotte Turkmen-Barta, Colette Chiland, Heino Meyer-Bahlburg, Domenico Di Ceglie, Ulrike Lehmkuhl, Orlando Uccellini, Mario Bertolini, Francesca Neri, Delia Albanese, Raffaella Bertola, Maartje Snoek, Martien Kas, Ulrike Margarete Elisabeth Schulze, Silke Calame, Ferdinand Keller, Stephanie Santel, Kerstin Krauel, Michael Rotte, Thomas F. Münte, Annemarie van Elburg, Fritz Poustka, Sven Bölte, Sabine Feineis-Matthews, Sven Boite, D. Hubl, D. Prvulovic, T. Dierks, Sabine Klauck, Irma Moilanen, M. Mattila, J. Laurila, K. Jussila, A. Pyper, S. L. Linna, Hanna Ebeling, D. Pauls, Pirjo Korpilahti, Soile Loukusa, Eira Jansson-Verkasalo, Johannes Hebebrand, Beate Herpertz-Dahlmann, Anke Hinney, Anne-Kathrin Wermter, Susann Friedel, Frank Geller, Helmut Schafer, Fernando Fernandez-Aranda, Joanna Holliday, Kristian Holtkamp, C. Mika, M. Heer, Rudolf Uher, Nicole Barbarich, Shannan E. Henry, Ursula Bailer, Guido Frank, Walter H. Kaye, Elisabet Wentz, J. Hubert Lacey, Glenn Waller, Maria Rastam, Jeremy Turk, Christopher Gillberg, Frank C. Verhulst, Marieke Zwaanswijk, Peter Verhaak, Jozien Bensing, Jan van der Ende, Frank Verhulst, Andre Sourander, Paivi Santalahti, Tamsin Ford, Robert Goodman, Howard Meltzer, Inge Seiffge-Krenke, Richard Fritsch, Marika Cutler, E. James Anthony, Per-Anders Rydelius, Rolf Castell, Milica Pejovic-Milovancevic, Miroslav Pavlovic, Noa Kalman, Muli Linder, Ido Luria, Yechiel Levkovitz, Kosuke Yamazaki, Pedro Caldeira da Silva, Grata Santos, Filipa Martins, Yen-Nan Chiu, Wen-Jer Tsai, Shur-Fen Gau, Chang-Chang Tseng, Shu-Chen Su, Jan Croonenberghs, Lucas Brouw, Annick Wauters, Nicole Bruning, Zina Manjaly, Gereon Fink, Olivera Aleksic, Nenad Rudic, Lucres Jansen, Christine C. Gispen-De Wied, Bertine Lahuis, Hanna Swaab, Jolijn Pietersen, Carolien Gevers, Inge Kamp-Becker, Isabell Germerott, Patricia Howlin, null Gaudière, Barbara Forresi, G. Lepri, Soumaila Laval, Andreas Wiefel, Z. Biringen, Karl Titze, K. Lenz, C. Seither, B. Witte, Marguerite Dunitz-Scheer, Markus Wilken, Alexandra Krasnovsky, Peter Scheer, Maria Cordeiro, Filippo Muratori, B. Felloni, A. Cesari, Linda Helmig, Peter Fonagy, Chris Moody, Jim Fultz, René Glanzmann, Nathalie Lutz-Latil, Agnes van Wyl, Dainius Puras, Amaia Hervds, John Tsiantis, T. Dragonas, H. Davis, V. Ispanovic, A. Paradisiotou, Mimoza Shanini, Lynne Jones, A. Uka, A. Rrustemi, Anne-Liis von Knorring, Dirk Deboutte, Souraya Dorhmi, Mohamed Agoub, Driss Moussaoui, Omar Battas, Inger Halvorsen, Anne Andersen, Sonja Heyerdahl, Denise Baillot, Michele La Roche, Claudia Furino, Annick Buchholtz, Gary Goldfield, Katherine Henderson, Ulrich Hagenah, Varinja Blume, Marlene Flacke-Redanz, Beate Herpertz Dahlmann, Angelique A. Sallas, Hubertus Adam, null Mozambique, Aferdita Goci-Uka, Susanne Schlüter-Müller, Umesh Bawa, Fakhri Khalik, Nima Forouher, Miyuki Sadamatsu, null Nanba, Nobumasa Kato, Kiyoto Kasai, Eiji Nanba, Martin H. Schmidt, Günter Esser, Herman van Engeland, Sophie Willemsen-Swinkels, Claudine Dietz, Anne Claire Beernink, Oliver Vidojevic, Ivona Milacic, Rael Strous, Roni Hegesh, Simion Kertzman, Z. Ben-Nahum, Moshe Kotler, Emma van Daalen, Mijke Zeegers, Hilleke Hulshoff Pol, Charles Williams, Jessica Sank, Martha Paulk, George Schwarz, Paul Wharton, Marija Raleva, Kamka Paketchieva, Angelina Filipovska, Carole Müller Nix, Margarita Forcada Guex, Abdel-Mohsen Daigham, Marit S. Indredavik, Torstein Vik, Siri Kulseng, Ann-Mari Brubakk, Marion Cuddy, Katharine Riley, Brigitte Vollmer, John Wyatt, Robin Murray, Mika Soininen, E. Juulia Paavonen, Mika Fjällberg, Juha Salmi, Almgvist Fredrik, Eeva T. Aronen, Olaf Reis, Stephanie P. Bohne, Susanne Kraenz, Dong-Hyun Ahn, Tae-Ho Kim, Jun-Ho Choi, Yun-Young Kim, Ivan Begovac, Milena Skocic, Vlasta Rudan, Oleg Filipovic, Tomasz Wolanczyk, Anita Brynska, Stanislaw Wojtowicz, Salvador Celia, Cisca Aerts, Elisabeth Cleve, Hellmut Hartmann, Hans-Jürgen Kühle, Fridjof Heidorn, Solveigh Zeyer, Joaquin Fuentes, Andrés Martin, Denis G. Sukhodolsky, Riittakerttu Kaltiala-Heino, Matti Rimpelä, Henrik Andershed, Deborah O’Donnell, Michelle Pearce, Dieter Burgin, Andreas Becker, Nicola Hagenberg, Matthias Berking, Veit Roessner, Ketil Hanssen-Bauer, Odd Aalen, Jürgen Junglas, Yoon-Seok Huh, Yun Young Kim, Kyung-Ja Oh, Kai Wang, Michael Tarren-Sweeney, D. M. Leiblum, Renate Kühl, Cornelia Nötzel, Ernst Pfeiffer, Klaus Lenz, Agneta Rosling, Marianne Poller, Donna Cross, Simone Klabin, Diana Kaplan, Lars Mickel, Gerd Lehmkuhl, Regina Möckel, Shani Leor, Leor Frisch, Amos Frisch, Abraham Weizman, Andrey Zanozin, Sylvie Jamart, Jean-Yves Hayez, Agnes Leor, Maria Elisabeth Ahle, Galit Ben Amitay, Irene Kosov, Ahuva Reiss, Moses Tamar, Hans Smedje, Hiie Allik, Jean Steyaert, Dries Castermans, John Creemers, Koenraad Devriendt Marta Kaczynska-Haladyj, Maria Claustre Jané Ballabriga, Joaquima Judez, Empar Pelaez, Pilar Sole, Lidia Rodriguez, Saskia Palmen, Chantal Kemner, Hugo Schnack, Rene Kahn, Anna Fabrizi, Levi Gabriel, Marcos Mercadante, Sergiode Paula Ramos, Maria Concecao Rosario-Campos, Michael Rutter, Stephan Collishaw, Barbara Maughan, Andrew Pickles, Julie Messer, Avshalom Caspi, Terrie Moffitt, Jana Kreppner, Anne Inger H. Borge, Suniya Luthar, Stephanie Hamarman, C. Ulger, J. Fossella, M. Brimacombe, J. Dermody, Mark Stein, L. D. Waldman, C. Sarampote, A. Robb, E. H. Cook, Aiveen Kirley, N. Lowe, Z. Hawi, C. Mullins, G. Daly, I. Waldman, M. McCarro, null O’Donell, Emma van der Meulen, S. C. Bakker, D. L. Pauls, R. J. Sinke, Guilherme Polanczyk, C. Zeni, J. P. Genro, Tatiana Roman, Mara Hutz, Christa Schaff, Patrick Haemmerle, Harald Sontag, Agnes Vetro, Julia Gadoros, Gotthard Roosen-Runge, Jocelyn Hattab, Peter Hummel, Orna Braun-Lewensohn, Daniel Schechter, Charles Zeanah, Michael Myers, Michael Liebowitz, Mark Davies, Wei-Tsuen Soong, Deborah James, Nick Sofroniou, Marine Gegelashvili, Umesh Parikh, John M. Kane, Anil K. Malhotra, Manoj Shah, Richard R. Pleak, Ronen Hizami, David Michelson, Marina Danckaerts, Alessandro Zuddas, Shuyu Zhang, Philip Hazell, P. Zeiner, M. Johnson, Frank Häßler, Prasad Suyash, Edmund Sonuga-Barke, Lynne Poole, Sarah Mares, Jon Jureidini, Zachary Steel, Louise Newman, Torsten Lucas, Stephanie Paulus, Martin Aßhauer, Birgit Miller, Gunilla Jarkman Björn, Christina Bodén, Per Gustafsson, Viola Povse Ivkic, Lazar Tenjovic, Radosavljev Jelena, Smiljka Popovic Deusic, Philip Graham, Henrikje Klasen, Jacinta Tan, Tony Hope, Anne Stewart, Raymond Fitzpatrick, Michael Kölch, Angeles Diaz-Caneja, Sonia Johnson, Ines Dippold, Katja Wiethoffi Ferdinand Keller, Sue Bailey, Nathan Whittle, Klaus Hennighausen, Gregor Kohls, Verena Maas, Tanja Rinker, Swantje Zachau, Gabriele Christmann, Anna Jaremkiewicz, Michael Schecker, Waldemar von Suchodoletz, Ruth Uwer, Ronald Albrecht, Lisa Glass, Valéria Csépe, Ferenc Honbology, Anett Rago, Eva Mészdros, Richard G. Schwartz, Valerie L. Shafer, Jonathan Green, C. Jacobs, L. Kroll, J. Briskman, G. Dunn, J. Beecham, B. Tobias, L. Baird, Terje Ogden, Michael Fitzgerald, Mark Bellgrove, Michael Gill, Ian H. Robertson, Paul McArdle, Amanda Burke, K. Michael Hong, Christina Hoven, Danuta Wasserman, Katharina Braun, Jórg Bock, Carina Helmecke, Michael Gruß, Gerd Poeggel, Charles Marsden, S. Muchimapura, M.-C. Pardon, M. Bianchi, Joram Feldon, Daniela Rüedi-Bettschen, Andrea C. Dettling, Christopher R. Pryce, Hans-Willi Clement, O. Sommer, A. Pschibul, C. Rombach, M. Gerlach, Claudia Mehler-Wex, S. Zeiske, E. Grünblatt, G. Gille, D. Rausch, Manfred Gerlach, Amira Seif El-Din, Nadia Kadri, Houda Hjiej Andaloussi, Khadija Chihabeddine, Mohammed Almaqrami, Alexander von Gontard, M. Okuno, Kurt Quaschner, Niels Bilenberg, Carsten Obel, Tine Brink Henriksen, Morten Hedegaard, Niels Jurgen Secher, Jorn Olsen, Antonio Fonseca, Isabelle Nathalie Koch, Ieva Bite, Phyllis Cohen, Katrin Russell, Nichaela Broyden, Gillian Lancaster, Christina Eichhorn, Karola Tiedtke, Ronald Feldman, Andreas Warnke, Peter Scheuerpflug, V. Vetter, Jürgen Bartling, Kerstin Konrad, Susanne Neufang, Charlotte Hanisch, Gereon R. Fink, Sarah Durston, Matthew C. Davidson, Nim Tottenham, Julie Spicer, Adriana Galvan, John Horvitz, John A. Fossella, Richard Watts, B. J. Casey, Daniel Brandeis, Andreas J. Fallgatter, Ann-Christine Ehlis, Jürgen Seifert, W. K. Strik, K. E. Zillessen, Martin J. Herrmann, Gerd Schulte-Körne, Heikki Lyytinen, Tomi Guttorm, Anna-Maija Poikkeus, Kenneth M. Eklund, Paula Lyytinen, Minna Torppa, M.-L. Laakso, E. Leskinen, A. Tolvanen, Silvia Paracchini, J. Schumacher, I. R. König, Claudia Libertus, Heide Griesemann, A. Kleensang, A. Ziegler, P. Propping, M. Näthen, Leo Wolmer, Iyad Zagout, Esti Galili-Weisstub, Gene Fisch, Ann Swillen, Annick Vogels, Christine Freitag, Jean-Francois Bouville, Laetitia Atlanti-Duault, Thierry Baubet, Robyn Osrow, Marie-Madeleine Leplomb, Yves Marchandy, Malika Bennabi, Ricardo Halpern, Odon Monteiro, Abbey-Robin Durkin, Rudy Haapanen, Susanne Bauer, Max Friedrich, Christina Stadler, Philipp Sterzer, Andreas Kleinschmidt, Irene Nowraty, W. E. Müller, Ulrich Knölker, Gabriele Schmid, Swantje Berndt, B. Behn, Jan Hendrik Puls, Luc Stevens, Joachim Jungmann, Zoran Juretic, Nela Ercegovic, Renate Schepker, Füsun Çuhadaroglu-Çetin, G. Herhaus, S. Melfsen, Daomeng Cheng, Donald Harder, Harry Laws, Yoshibumi Nakane, Kenzo Takeshita, Hiroshi Naruse, Yan Zhu, Jun Liu, Yasong Du, John Sikorski, Sannie Hamerlynck, Lisettet Hart, Lucres Nauta-Janssen, Prathiba Chitsabesan, Hien Nguyen, Jovan Simeon, Cathy Cuzner, Howard Schachter, Ana Soledade Martins, Chirstian Kieling, Julia Comassetto, Renata Goncalves, Silvia Oswald, Johannes Buchmann, J. Kirschner, M. Garvey, Gunther Moll, Hartmut Heinrich, Sameer Malhotra, Zeffie Poulakis, Sam Menahem, Karin Sauer, Tilouch Samia, Hannachi Rimeh, Missaoui Sonia, Mara Westling Allodi, Monica Biscaldi, Bettina Wagner, Chiyoko Uchida, Thomas Jozefiak, Roberta Penge, Valentina Ivancich Biaggini, Siv Fischbein, Matti Joukamaa, Anja Taanila, Juha Veijola, Juha T. Karvonen, Jouko Miettunen, Edelmira Domenech Llaberia, Teresa Corbella Domenech, Maria Claustre Jane Ballabriga, Josepa Canals Sanz, Griselda Esparo, Sergi Ballespi Sola, Xuejun Liu, Yukiko Kano, Masataka Ohta, Yoko Nagai, Takashi Arai, Su Linyan, Jeff Bridge, Boris Birmaher, Carlo Di Lorenzo, Satish Iyengar, David Brent, Bernhard Blanz, Laura Weninger, Gerhard Libal, Anna Skrabal, Michael Bowden, Howard Cooper, Inger Simonsen, Carl Bechstrom, Mette Medby, Ritva Erkolahti, Gunther Klosinski, Mihoko Oba, Satomi Murase, Takashi Murakami, Jiro Takai, Hitoshi Kaneko, Shuji Honjo, Katrina Rickards, Annhild Weber, Michael Karle, Alain Lazartigues, Pascale Planche, Eric Lemonnier, Mani Pavuluri, Lindsay Schenkel, Ryan Shaw, John Sweeny, Giancarlo Rigon, Stefano Costa, Alessandra Mancaruso, Roberta Mansi, Daniele Giovanni Poggioli, Simona Chiodo, Maja Radobuljac, Urban Groleger, Nada Ovsenik, Martina Tomori, Barbara Haas, Susanne Denoix, Franz Kimmig, Marc Weinhardt, Günter Schmitz, Berit Filschke, Conny Fliegauf, Ji-Hae Kim, Maya Krischer, Michael H. Stone, Kathrin Sevecke, Manfred Doepfner, Cornelia König, Dörte Grasmann, Michael Schlander, Stephen Ralston, R. Rodrigues Pereira, W. Brussel, L. Vlasveld, H. G. Tuynman-Qua, M. J. Lorenzo, R. Tauscher-Wisniewski, Stefano Palazzi, Ettore Guaia, Artur Kolakowski, Agnieszka Pisula, Timothy Wilens, Tobias Banaschewski, Henrik Uebel, Björn Albrecht, Monika Robatzek, Kristen Migliaccio-Walle, Jaime Caro, Albert J. Allen, R. Bart Sangal, Judith Owens, Douglas Kelsey, Virginia Sutton, Kory Schuh, Aliye Tugba Bahadir, Zeynep Yaman, Ayse Rodopman Arman, Kemal Kuscu, Yanki Yazgan, Meral Berkem, Peter Feldman, Milton Denai, Alexander Simpson, Christopher Kratochvil, Jeffrey Newcorn, Joseph Biederman, Douglas Gelowitz, Christine Thomason, Haitao Gao, Patricia Bijttebier, Steff Decoene, Pia Niklaus, Nils Duits, Ulrich Auer, Kathleen Schnoor, Detlef Schläfke, Füsun Çuhadaroälu Çetin, Gordon Harper, Sami Hamdan, Muhammed El-Haib, Saynur Canat, Olivier Halfon, Monique Bolognini, B. Plancherel, Olivier Phan, Maurice Corcos, Jean-René Cardinaux, Pierre J. Magistretti, Blaise Pierrehumbert, Minna Koskinen, Ulf Engqvist, Matthew Allin, Larry Rifkin, Sandra Lancaster, Ayala Borghini, Laure Jaugey, Margarita Forcada-Guex, Lyne Jaunin, Carole Müller-Nix, François Ansermet, Mariada Conceicao Taborda Simoes, Luiza Nobre Lima, Mariada Luz Vale Dias, Rainer Georg Siefen, Ariel Como, Valbona Alikaj, Sonila Tomori, Flavia Capozzi, Angela Romano, Mara Roello, Francesca Piperno, Mali A. Mann, Dieter Stösser, Gottfried Barth, Alina Pimenov, Jenny Schwab, Hülya Bingöl, Rémy Barbe, Heba Elkshishy, Ana Jovanovic, Aneta Lakic, Vesna Milovanovic, Milorad Vukasinovic, Jeffrey Bridge, David Kolko, David A. Brent, Kathryn Gilson, Roslyn Montague, Ian Shochet, Cristina Maria Ribeiro Marques, Teresa Cepeda, Carolin Ligges, Marc Ligges, Ralph Huonker, Paavo Leppänen, Torni K. Guttorm, Jarmo Hämäläinen, Anne Puolakanaho, Ellen Plume, Inke R. König, Wolfgang Deimel, Markus M. Nöthen, Peter Propping, André Kleensang, Bertram Müller-Myhsok, Andreas Ziegler, Sung-Do David Hong, Xueping Gao, Xuerong Li, Soyoung Irene Lee, Eui-Jung Kim, In-Hee Cho, Ji-Hoon Kim, Se-Hyun Park, J-Wook Choi, Steffen Heger, Andreas Schreiner, Klaus Rettig, Rossella Medori, Peik Gustafsson, Kjell Hansson, Lena Eidevall, Gunilla Thernlund, Philip Heiser, A. Dempfle, Judith Smidt, Justyna Grabarkiewicz, Hans Kiefl, U. Hemminger, K. Saar, James Swanson, Nora D. Volkov, S. Gupta, L. Williams, D. Agler, M. Wasdell, S. Wigal, Silvia Martins, Silza Tramontina, Mariana Eizirik, Benedetto Vitiello, Walter Clevenger, Stephen Faraone, James McGough, James McCracken, Luis Augusto Rohde, Larry Greenhill, Michael Leary, Bo Larsson, W. Boudewijn Gunning, Jean-Marie Villat, Redmond O’Connell, Mark A. Bellgrove, Paul Dockree, Raymond Traube, Mary Braunschweig, Jacques Chabanier, Germana De Leo, Margerita Ibanez, Olivette Mikolajaks, Ida Ropstad, J. Gerald Young, Rachele Aiello, Viviana Porcari, Maria Patrizia Salatiello, Anna Lo Bue, Valentina Dell’Oglio, Rosaria Cardella, Sabrina Chifari, Anne Mari Undheim, Linyan Su, Xuerong Luo, Joanne Barton, Lioba Baying, Thomas Rellum, Emrah Duezel, Hermann Hinrichs, Christoph Bartel, Iris Linde, E. Friederichs, Mark Bangs, Helmut Remschmidt, Theodore Doreleijers, Elisabeth Rebernig, Giovanni Battista Camerini, Soraya Otero, Ana Rivas, Guadalupe Pombo, Maruke Yeghiyan, Gasparyan Kachatur, Arman Danileyan, Tord Ivarsson, Robert Valderhaug, Susanne Walitza, Christoph Wewetzer, Nikolaus Barth, F. Hahn, Fernando Asbahr, Ana Regina Castillo, Ligia Ito, Mariado Rosario Latorre, Michelle Moreira, Francisco Lotufo-Neto, Sophie Symann, Dominique Charlier, Belinda Plattner, Astrid Elisabeth Schallauer, Beat Mohler, P. Staub, Carsten Müller, Rieke Oelkers-Ax, Jochen Fischer, Uta Hermanns, Anne Nickel, Hans Volker Bolay, Miguel Cherro-Aguerre, Merete Juul Sorensen, Judith Becker Nissen, Ole Mors, Per Hove Thomsen, Anne Mari Sund, May Britt Drugli, Lars Wichstrom, Matthias Schwannauer, Emily Taylor, Rob Wrate, Matthias Martin, Jan-Olov Larsson, Henrik Larsson, Paul Lichtenstein, Andrea G. Ludolph, Felix Mottaghy, Susanne Kraemer, Dieter Claus, Bernhard Krause, Jbrg M. Fegert, Tuula Hurtig, Anna Malakhova, Katerina Maniadaki, Efthymios Kakouros, Peter Jensen, Joe Albert Garcia, Sherry Glied, Maura Crowe, E. Michael Foster, Bernard Golse, Jenny Junghanß, Aino-Maija Salin, Päivi Rytölä, and Pauliina Hiltunen

Published
2004
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43. Migration background and juvenile mental health: a descriptive retrospective analysis of diagnostic rates of psychiatric disorders in young people

Author

Florian D. Zepf, Beate Herpertz-Dahlmann, T. J. Gaber, Fritz Poustka, Samira Bouyrakhen, Christine M. Freitag, Ulrich Hagenah, Martin Holtmann, Lars Wöckel, and This study was funded by the German Society for Social Pediatrics and Adolescent Medicine (Deutsche Gesellschaft für Sozialpädiatrie und Jugendmedizin, DGSPJ).

Subjects
Male, Immigration, RA790-790.95 Mental health. Mental illness prevention, Mental health, Medicine, Public Health, Stress Disorders, Post-Traumatic, Adolescent Psychiatry, Risk Factors, Germany, Child and adolescent psychiatry, adolescents, Child, media_common, education.field_of_study, lcsh:Public aspects of medicine, Mental Disorders, Health Policy, Age Factors, Emigration and Immigration, immigration issues, risk factors, mental health, children, Mental Health, Child, Preschool, Original Article, Female, medicine.medical_specialty, Adolescent, media_common.quotation_subject, Adjustment disorders, Population, Adjustment Disorders, Sex Factors, Humans, Juvenile, ddc:610, Psychiatry, education, Socioeconomic status, Retrospective Studies, business.industry, Public Health, Environmental and Occupational Health, Infant, lcsh:RA1-1270, Retrospective cohort study, medicine.disease, Socioeconomic Factors, business, Stress, Psychological
Abstract

Introduction: This article presents diagnostic rates for specific mental disorders in a German pediatric inpatient population over a period of 20 years with respect to migration background and socioeconomic status (SES). Methods: Diagnostic data were obtained over a period of 20 years from 8,904 patients who visited a child and adolescent psychiatry mental health service in Germany. Data from 5,985 diagnosed patients (ICD-9 and ICD-10 criteria) were included with respect to gender, migration background, and SES. Results: Migration- and gender-specific effects were found for both periods of assessment. The group of boys with a migration background showed significantly higher rates of reactions to severe stress, adjustment disorders, and posttraumatic stress disorder compared to their male, non-migrant counterparts. Conversely, boys without a migration background showed a significantly higher percentage rate of hyperkinetic disorders than male migrants. Similar results were found for female migrants in the latter assessment period (ICD-10). In addition, female migrants showed lower rates of emotional disorders whose onset occurs in childhood compared to their non-migrant counterparts. Conclusions: Data from this investigation provide preliminary evidence that the prevalence of various psychiatric disorders in children and adolescents is influenced by migration background and SES. Keywords: immigration issues; risk factors; mental health; children; adolescents (Published: 19 June 2013) Citation: Glob Health Action 2013, 6 : 20187 - http://dx.doi.org/10.3402/gha.v6i0.20187

Published
2013
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