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1. Lung-function trajectories: relevance and implementation in clinical practice

Author

Abellan, Alicia, Adcock, Ian, Afzal, Shoaib, Alter, Peter, Backman, Helena, Bertels, Xander, Bloom, Chloe, Bønnelykke, Klaus, Breyer, Marie-Kathrin, Casas, Sandra, Chung, Fan (Kian), Colak, Yunus, Cosio, Borja G., Duijts, Liesbeth, Fabbri, Leonardo, Fontanella, Sara, Fuertes, Elaine, Gonzalez, Juan Ramón, Granell, Raquel, Hartl, Sylvia, Hernandez-Pacheco, Natalia, Holloway, John, Jarvis, Deborah, Koefoed, Hans Jacob, Kole, Tessa, Kumar, Ashish, Langhammer, Arnulf, Lindberg, Anne, Llopis, Maria, Maitland van der Zee, Anke-Hilse, Meteran, Howraman, Minelli, Cosetta, Nwaru, Bright, Olvera, Nuria, Peralta, Gabriela, Ritchie, Andrew, Rönmark, Eva, Ross Chapman, James, Sangüesa Boix, Júlia, Schikowski, Tamara, Schlünssen, Vivi, Shaheen, Seif, Sigsgaard, Torben, Standl, Marie, Talaei, Mohammad, Ullah, Anhar, Ullman, Anders, Valencia-Hernandez, Carlos, van den Berge, Maarten, van Dijk, Yoni, Vestbo, Jørgen, Vijverberg, Susanne, Vikjord, Sigrid Anna, Volgelmeier, Claus, Vonk, Judith, Zounemat Kermani, Nazanin, Melén, Erik, Faner, Rosa, Allinson, James P, Bui, Dinh, Bush, Andrew, Custovic, Adnan, Garcia-Aymerich, Judith, Guerra, Stefano, Breyer-Kohansal, Robab, Hallberg, Jenny, Lahousse, Lies, Martinez, Fernando D, Merid, Simon Kebede, Powell, Pippa, Pinnock, Hilary, Stanojevic, Sanja, Vanfleteren, Lowie E G W, Wang, Gang, Dharmage, Shyamali C, Wedzicha, Jadwiga, and Agusti, Alvar

Published
2024
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2. Lung-function trajectories: relevance and implementation in clinical practice

Author

Melén, Erik, primary, Faner, Rosa, additional, Allinson, James P, additional, Bui, Dinh, additional, Bush, Andrew, additional, Custovic, Adnan, additional, Garcia-Aymerich, Judith, additional, Guerra, Stefano, additional, Breyer-Kohansal, Robab, additional, Hallberg, Jenny, additional, Lahousse, Lies, additional, Martinez, Fernando D, additional, Merid, Simon Kebede, additional, Powell, Pippa, additional, Pinnock, Hilary, additional, Stanojevic, Sanja, additional, Vanfleteren, Lowie E G W, additional, Wang, Gang, additional, Dharmage, Shyamali C, additional, Wedzicha, Jadwiga, additional, Agusti, Alvar, additional, Abellan, Alicia, additional, Adcock, Ian, additional, Afzal, Shoaib, additional, Alter, Peter, additional, Backman, Helena, additional, Bertels, Xander, additional, Bloom, Chloe, additional, Bønnelykke, Klaus, additional, Breyer, Marie-Kathrin, additional, Casas, Sandra, additional, Chung, Fan (Kian), additional, Colak, Yunus, additional, Cosio, Borja G., additional, Duijts, Liesbeth, additional, Fabbri, Leonardo, additional, Fontanella, Sara, additional, Fuertes, Elaine, additional, Gonzalez, Juan Ramón, additional, Granell, Raquel, additional, Hartl, Sylvia, additional, Hernandez-Pacheco, Natalia, additional, Holloway, John, additional, Jarvis, Deborah, additional, Koefoed, Hans Jacob, additional, Kole, Tessa, additional, Kumar, Ashish, additional, Langhammer, Arnulf, additional, Lindberg, Anne, additional, Llopis, Maria, additional, Maitland van der Zee, Anke-Hilse, additional, Meteran, Howraman, additional, Minelli, Cosetta, additional, Nwaru, Bright, additional, Olvera, Nuria, additional, Peralta, Gabriela, additional, Ritchie, Andrew, additional, Rönmark, Eva, additional, Ross Chapman, James, additional, Sangüesa Boix, Júlia, additional, Schikowski, Tamara, additional, Schlünssen, Vivi, additional, Shaheen, Seif, additional, Sigsgaard, Torben, additional, Standl, Marie, additional, Talaei, Mohammad, additional, Ullah, Anhar, additional, Ullman, Anders, additional, Valencia-Hernandez, Carlos, additional, van den Berge, Maarten, additional, van Dijk, Yoni, additional, Vestbo, Jørgen, additional, Vijverberg, Susanne, additional, Vikjord, Sigrid Anna, additional, Volgelmeier, Claus, additional, Vonk, Judith, additional, and Zounemat Kermani, Nazanin, additional

Published
2024
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7. Additional file 5 of Decreased COPD prevalence in Sweden after decades of decrease in smoking

Author

Backman, Helena, Vanfleteren, Lowie, Lindberg, Anne, Ekerljung, Linda, Stridsman, Caroline, Axelsson, Malin, Nilsson, Ulf, Bright I. Nwaru, Sawalha, Sami, Berne Eriksson, Hedman, Linnea, Rådinger, Madeleine, Sven-Arne Jansson, Ullman, Anders, Kankaanranta, Hannu, Lötvall, Jan, Rönmark, Eva, and Lundbäck, Bo

Abstract

Additional file 3: Tables S1–S6.

Published
2020
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8. Additional file 1 of Decreased COPD prevalence in Sweden after decades of decrease in smoking

Author

Backman, Helena, Vanfleteren, Lowie, Lindberg, Anne, Ekerljung, Linda, Stridsman, Caroline, Axelsson, Malin, Nilsson, Ulf, Bright I. Nwaru, Sawalha, Sami, Berne Eriksson, Hedman, Linnea, Rådinger, Madeleine, Sven-Arne Jansson, Ullman, Anders, Kankaanranta, Hannu, Lötvall, Jan, Rönmark, Eva, and Lundbäck, Bo

Subjects
Data_FILES
Abstract

Additional file 5. Methods.

Published
2020
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10. Effect of inhaled formoterol and budesonide on exacerbations of asthma

Author

Pauwells, Romain A., Lofdahl, Claes-Goran, Postma, Dirkje S., Tattersfield, Anne E., O'Byrne, Paul, Barnes, Peter J., and Ullman, Anders

Subjects
Asthma -- Drug therapy, Formoterol -- Evaluation, Budesonide -- Evaluation
Abstract

The addition of a long-acting beta 2-agonist, formoterol, to inhaled glucocorticoid therapy could result in the improvement of symptoms and lung function in patients with persistent asthma. A total of 852 patients with recurrent asthma were placed in one of four treatment groups. The addition of formoterol to a group receiving low doses of the glucocorticoid budesonide, as well as a group inhaling a higher dose of the steroid, decreased the frequency of both severe and mild symptoms. The higher dose of budesonide alone also lessened the number of exacerbations, especially of severe asthmatic incidents.

Published
1997

12. Chronic Airway Diseases Early Stratification (CADSET): a new ERS Clinical Research Collaboration

Author

Agusti, Alvar, Faner, Rosa, Donaldson, Gavin, Heuvelin, Elise, Breyer-Kohansal, Robab, Melén, Erik, Maitland-van der Zee, Anke H., Vestbo, J. rgen, Allinson, James P., Vanfleteren, Lowie E. G. W., van den Berge, Maarten, Adcock, Ian M., Lahousse, Lies, Brusselle, Guy, Wedzicha, Jadwiga A., Maitland-van der Zee, Anke-Hilse, Alter, Peter, Barbe, Ferran, Brightling, Christopher E., Breyer, Marie-Kathrin, Burghuber, Otto C., Casas, Maribel, Chung, Kian Fan, Cosío, Borja G., Crispi, Fatima, Batlle, Jordi de, Fitting, Jean-William, Garcia, Judith, Hallberg, Jenny, Hartl, Sylvia, Jarvis, Deborah, Mathioudakis, Alexander, Nicod, Laurent, Papi, Alberto, Ritchie, Andrew, Sigsgaard, Torben, Sterk, Peter J., Ullman, Anders, Paediatric Pulmonology, Pulmonology, and APH - Personalized Medicine

Subjects
IMPACT, Respiratory System, CHILDHOOD, Pulmonary Disease, Chronic Obstructive, 0302 clinical medicine, PRECISION MEDICINE, Pulmonary Medicine, 030212 general & internal medicine, Registries, Child, Lung, Lung function, Societies, Medical, RISK, Geography, 11 Medical And Health Sciences, Middle Aged, 3. Good health, Europe, Interinstitutional Relations, Current members of the CADSET Clinical Research Collaboration, Child, Preschool, Pulmonary and Respiratory Medicine, Adult, medicine.medical_specialty, PRETERM BIRTH, Adolescent, Interdisciplinary Research, Pulmonary disease, 03 medical and health sciences, Young Adult, medicine, Humans, Intensive care medicine, LUNG-FUNCTION TRAJECTORIES, Aged, business.industry, Infant, Newborn, Infant, NATURAL-HISTORY, Precision medicine, LIFE, Airway Obstruction, Clinical research, 030228 respiratory system, ASTHMA, business, Airway, on behalf of the CADSET Clinical Research Collaboration
Abstract

A recent editorial in the European Respiratory Journal highlighted the strategic importance of the Clinical Research Collaborations (CRCs) launched in 2013 by the European Respiratory Society (ERS) [1]. These have the aim of 1) promoting the exchange of research ideas among clinicians and affiliated scientists in Europe and/or globally; 2) building an infrastructure for prospective clinical research; 3) securing additional funding through national and European Union funding streams; and 4) facilitating the planning, implementation, evaluation and publication of clinical and translational studies at pan-European level and beyond. So far, there are currently 17 ongoing CRCs that cover eight major respiratory disease domains (airway diseases, interstitial lung diseases, pulmonary vascular diseases, sleep and breathing disorders, respiratory critical care, paediatric respiratory diseases, respiratory infections and thoracic oncology), all of them linked to one or more ERS assemblies [2–12]. CADSET, an acronym that stands for “Chronic Airway Diseases Early Stratification”, is the latest addition to the list of ongoing CRCs (www.ersnet.org/research/clinical-research-collaborations). This editorial presents the rationale, goals and research strategy for CADSET.

Published
2019
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21. Prediction of COPD and Related Events Improves by Combining Spirometry and the Single Breath Nitrogen Test

Author

Olofson, Jan, Bake, Björn, Bergman, Bengt, Ullman, Anders, Svärdsudd, Kurt, Olofson, Jan, Bake, Björn, Bergman, Bengt, Ullman, Anders, and Svärdsudd, Kurt

Abstract

Chronic obstructive pulmonary disease (COPD) develops in small airways. Severity of small airway pathology relates to progression and mortality. The present study evaluated the prediction of COPD of a validated test for small airway disease, i.e. a slope of the alveolar plateau of the single breath nitrogen test (N2-slope). The N2-slope, spirometry, age, smoking habits, and anthropometric variables at baseline were obtained in a population-based sample (n = 592). The cohort was followed for first COPD events (first hospital admission of COPD or related conditions or death from COPD) during 38 years. During follow-up, 52 subjects (8.8%) had a first COPD event, of which 18 (3.0%) died with a first COPD diagnosis. In the proportional hazard regression analysis adjusted for age and smoking habits, the cumulative COPD event incidence increased from 5% among those with high forced expired volume in one second (FEV1) to 25% among those with low FEV1, while increasing from 4% among those with the lowest N2-slope to 26% among those with the highest. However, combining the N2-slope and FEV1 resulted in considerable synergy in the prediction of first COPD event and even more so when taking account of smoking habits. The cumulative COPD event incidence rate was 75% among heavy smokers with the highest N2-slope and lowest FEV1, and less than 1% among never smokers with the lowest N2-slope and highest FEV1. Thus, combining the results of the single breath N2-slope and FEV1 considerably improved the prediction of COPD events as compared to either test alone.

Published
2018
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22. Decrease in prevalence of COPD in Sweden after decades of decrease in smoking

Author

Backman, Helena, Ekerljung, Linda, Eriksson, Berne, Stridsman, Caroline, Mincheva, Roxana, Hedman, Linnea, Hagstad, Stig, Lindberg, Anne, Ullman, Anders, Rönmark, Eva, Lundback, Bo, Backman, Helena, Ekerljung, Linda, Eriksson, Berne, Stridsman, Caroline, Mincheva, Roxana, Hedman, Linnea, Hagstad, Stig, Lindberg, Anne, Ullman, Anders, Rönmark, Eva, and Lundback, Bo

Abstract

Background: The smoking prevalence in Sweden has steadily decreased during three decades. The prevalence of COPD in Sweden in the 1990s and around the millennium shift was similar to neighboring European countries, i.e. estimated at 11-17%, and of moderate to severe COPD to 7-11%, in ages over 40y. Aim: Has the prevalence of chronic airway obstruction (CAO) and of COPD in Sweden decreased after decades of decreasing smoking prevalence? Methods: Within two large scale population studies in progress, the West Sweden Asthma Study (WSAS) and the Obstructive Lung Disease in Northern Sweden Studies (OLIN), the prevalence of COPD in ages 41-72y was calculated among randomly selected subjects from the general population in 2009-2012. The following post-bronchodilator definitions were used; CAO: FEV1/FVC40 years, the prevalence of COPD has decreased in Sweden, and the decrease in smoking over decades is probably the main causal factor., Supplement: 62Meeting Abstract: OA1935

Published
2018
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25. Early intervention with budesonide in mild persistent asthma: a randomised, double-blind trial.

Author

Pauwels, Romain, Pedersen, Søren, Bruss, William, Tan, Wang-Chiew, Chen, Yi-Wen, Ohlsson, Stefan V, Lamm, Carl Johan, Ullman, Anders, O'Byrne, Paul M, Casimir, Georges, Pauwels, Romain, Pedersen, Søren, Bruss, William, Tan, Wang-Chiew, Chen, Yi-Wen, Ohlsson, Stefan V, Lamm, Carl Johan, Ullman, Anders, O'Byrne, Paul M, and Casimir, Georges

Abstract

Although inhaled glucocorticosteroids are recommended for persistent asthma, their long-term effect on recent onset, mild, persistent asthma has yet to be established., Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, info:eu-repo/semantics/published

Published
2003

27. Exacerbations of Asthma

Author

TATTERSFIELD, ANNE E., primary, POSTMA, DIRKJE S., additional, BARNES, PETER J., additional, SVENSSON, KLAS, additional, BAUER, CARL-AXEL, additional, O'BYRNE, PAUL M., additional, LÖFDAHL, CLAES-GÖRAN, additional, PAUWELS, ROMAIN A., additional, and ULLMAN, ANDERS, additional

Published
1999
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