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Inadequate breast milk production is the most common inhibiting factor causing the cessation of exclusive breastfeeding practices an effort to increase the rate of secretion and production of breast milk is through the use of traditional herbal medicines such as decoction and extraction of katuk leaf (Sauropus androgynus). Katuk leaf extract (Sauropus androgynus) has been known to have a variety of pharmacological activities. This paper aims to review the botany, phytochemistry, ethnopharmacology, and pharmacological activities of S. androgynus, and discuss the known chemical constituents at work in S. androgynus-induced prolactin level to increasing breast milk human. The data presented in this review were collected from published literatures as well as the electronic databases of PubMed, CNKI, Web of Science, SCI finder, ACS, Science Direct, Wiley, Springer, Taylor, Google Scholar, and a number of unpublished resources, (ex: books, and Ph.D. and M.Sc. dissertations). Searching for research articles in several databases using certain keywords breast milk human and katuk (Sauropus Androgynus) leaf literature. All abstracts retrieved were screened for inclusion. All types of articles, including case series and case reports, were included due to the lack of herbal katuk leaf clinical trials. Exclusion criteria consisted of non-English and nonhuman articles. In conclusion, there was a significant effect of katuk leaf consumption towards increasing breastmilk production volume.