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161 results on '"Ukwaja, KN"'

1. Tezepelumab for Patients with Severe Uncontrolled Asthma: A Systematic Review and Meta-Analysis

Author: Zoumot Z, Al Busaidi N, Tashkandi W, Aljohaney AA, Isse S, Vidyasagar K, and Ukwaja KN
Subjects: tezepelumab, asthma, quality of life, systematic review, meta-analysis, Immunologic diseases. Allergy, RC581-607
Abstract: Zaid Zoumot,1 Nasser Al Busaidi,2 Wail Tashkandi,3 Ahmed A Aljohaney,4 Said Isse,1 Kota Vidyasagar,5 Kingsley Nnanna Ukwaja6 1Respiratory Institute Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates; 2Department of Pulmonology, Royal Hospital, Muscat, Sultanate of Oman; 3Department of Surgery, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia; 4Department of Internal Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia; 5Department of Pharmacy, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Telangana, 506009, India; 6Department of Medicine, Alex Ekwueme Federal University Teaching Hospital, Abakaliki, Ebonyi State, NigeriaCorrespondence: Zaid Zoumot, Respiratory Institute Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates, Email zzoumot@doctors.org.ukAbstract: Tezepelumab is a human monoclonal antibody that blocks thymic stromal lymphopoietin, an epithelial-cell-derived cytokine implicated in the pathogenesis of asthma. It was approved by the United States Federal Drug Administration (US FDA) as an add-on maintenance treatment for patients with severe uncontrolled asthma in December 2021. We conducted a systematic review and meta-analysis to investigate the safety and efficacy of tezepelumab on forced expiratory volume (FEV1) (L), the rate of asthma exacerbations, health-related quality of life, fractional exhaled nitric oxide (FeNO) (ppb), and blood eosinophil count (cells/mL) in patients with severe, uncontrolled asthma. Mean changes for efficacy and proportions (safety) with their corresponding 95% confidence intervals (CIs) were used to provide pooled estimates. A total of six randomized controlled trials comprising 2667 patients were included, of whom 1610 were treated with tezepelumab and 1057 received placebo. The pooled analysis showed that tezepelumab treatment resulted in an improvement in FEV1 of 0.15 L (95% CI: 0.12 to 0.17), a reduction in the asthma exacerbation rate per year of 0.60 (95% CI: 0.51 to 0.70), and a reduction in FeNO of − 12.41 ppb (95% CI: − 14.28 to − 10.53) when compared to placebo. Improvements in FEV1 and FeNO levels were maintained at 24 and 52 weeks. As for safety, patients did not experience a higher incidence of adverse drug reactions with tezepelumab (0.79 (95% CI: 0.55 to 1.12)) as compared to placebo. As for quality of life, different doses of the tezepelumab intervention group depicted non-significant improvement in the QoL, from 0.15 (95% CI: − 0.09 to 0.38) for 70 mg, 0.18 (95% CI: − 0.10 to 0.46) for 210 mg, 0.08 (95% CI: − 0.16 to 0.32) for 280 mg as compared to the placebo. Tezepelumab significantly reduced exacerbation rates and improved FEV1 with an acceptable safety profile.Keywords: tezepelumab, asthma, quality of life, systematic review, meta-analysis
Published: 2022

2. Household catastrophic payments for tuberculosis care in Nigeria: Incidence, determinants, and policy implications for universal health coverage

Author: Hopewell, Philip, Ukwaja, KN, Alobu, I, Abimbola, S, and Hopewell, PC
Abstract: Background: Studies on costs incurred by patients for tuberculosis (TB) care are limited as these costs are reported as averages, and the economic impact of the costs is estimated based on average patient/household incomes. Average expenditures do not repr
Published: 2013

3. The High Cost of Free Tuberculosis Services: Patient and Household Costs Associated with Tuberculosis Care in Ebonyi State, Nigeria

Author: Hopewell, Philip, Ukwaja, KN, Alobu, I, lgwenyi, C, and Hopewell, PC
Abstract: Objective:Poverty is both a cause and consequence of tuberculosis. The objective of this study is to quantify patient/household costs for an episode of tuberculosis (TB), its relationships with household impoverishment, and the strategies used to cope with
Published: 2013

4. Global, regional, and national burden of Parkinson's disease, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

Author: Dorsey, ER, Elbaz, A, Nichols, E, Abd-Allah, F, Abdelalim, A, Adsuar, JC, Ansha, MG, Brayne, C, Choi, J-YJ, Collado-Mateo, D, Dahodwala, N, Huyen, PD, Edessa, D, Endres, M, Fereshtehnejad, S-M, Foreman, KJ, Gbetoho Gankpe, F, Gupta, R, Hankey, GJ, Hay, SI, Hegazy, MI, Hibstu, DT, Kasaeian, A, Khader, Y, Khalil, I, Khang, Y-H, Kim, YJ, Kokubo, Y, Logroscino, G, Massano, J, Ibrahim, NM, Mohammed, AM, Mohammadi, A, Moradi-Lakeh, M, Naghavi, M, Binh, TN, Nirayo, YL, Ogbo, FA, Owolabi, MO, Pereira, DM, Postma, MJ, Qorbani, M, Rahman, MA, Roba, KT, Safari, H, Safiri, S, Satpathy, M, Sawhney, M, Shafieesabet, A, Shiferaw, MS, Smith, M, Szoeke, CEI, Tabares-Seisdedos, R, Nu, TT, Ukwaja, KN, Venketasubramanian, N, Villafaina, S, Weldegwergs, KG, Westerman, R, Wijeratne, T, Winkler, AS, Bach, TX, Yonemoto, N, Feigin, VL, Vos, T, and Murray, CJL
Subjects: Uncategorized
Abstract: [Background] Neurological disorders are now the leading source of disability globally, and ageing is increasing the burden of neurodegenerative disorders, including Parkinson's disease. We aimed to determine the global burden of Parkinson's disease between 1990 and 2016 to identify trends and to enable appropriate public health, medical, and scientific responses. [Methods] Through a systematic analysis of epidemiological studies, we estimated global, regional, and country-specific prevalence and years of life lived with disability for Parkinson's disease from 1990 to 2016. We estimated the proportion of mild, moderate, and severe Parkinson's disease on the basis of studies that used the Hoehn and Yahr scale and assigned disability weights to each level. We jointly modelled prevalence and excess mortality risk in a natural history model to derive estimates of deaths due to Parkinson's disease. Death counts were multiplied by values from the Global Burden of Disease study's standard life expectancy to compute years of life lost. Disability-adjusted life-years (DALYs) were computed as the sum of years lived with disability and years of life lost. We also analysed results based on the Socio-demographic Index, a compound measure of income per capita, education, and fertility. [Findings] In 2016, 6·1 million (95% uncertainty interval [UI] 5·0–7·3) individuals had Parkinson's disease globally, compared with 2·5 million (2·0–3·0) in 1990. This increase was not solely due to increasing numbers of older people, because age-standardised prevalence rates increased by 21·7% (95% UI 18·1–25·3) over the same period (compared with an increase of 74·3%, 95% UI 69·2–79·6, for crude prevalence rates). Parkinson's disease caused 3·2 million (95% UI 2·6–4·0) DALYs and 211 296 deaths (95% UI 167 771–265 160) in 2016. The male-to-female ratios of age-standardised prevalence rates were similar in 2016 (1·40, 95% UI 1·36–1·43) and 1990 (1·37, 1·34–1·40). From 1990 to 2016, age-standardised prevalence, DALY rates, and death rates increased for all global burden of disease regions except for southern Latin America, eastern Europe, and Oceania. In addition, age-standardised DALY rates generally increased across the Socio-demographic Index. [Interpretation] Over the past generation, the global burden of Parkinson's disease has more than doubled as a result of increasing numbers of older people, with potential contributions from longer disease duration and environmental factors. Demographic and potentially other factors are poised to increase the future burden of Parkinson's disease substantially. [Finding] Bill & Melinda Gates Foundation.
Published: 2023
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5. Time to wound healing and determinants of delayed wound healing among Buruli ulcer patients in Nigeria

Author: Meka, AO, Chukwu, JN, Nwafor, CC, Njoku, MI, Ekeke, N, Murphy-Okpala, NN, Eze, CC, Ezeakile, OE, Ossai, EN, and Ukwaja, KN
Subjects: Buruli Ulcer, Wound healing, Determinants, Delay, Nigeria
Abstract: Background: Little is known about the healing time of ulcers in Buruli Ulcer (BU) and its determinants among BU patients in endemic settings.Objective: The objective of this study was to evaluate the healing time and determinants of prolonged wound healing among BU patients in Nigeria.Methods: This was a prospective cohort study of all BU patients managed in BU treatment centres in three states in Nigeria during April 2017 to August 2019.Results: A total of 46 BU patients were enrolled during the study period; 25 (54.3%) were male, 30 (65.2%) were adults, and 43 (93.5%) of the participants presented as new case. Also, 42 (91.3%) presented with ulcer, 40 (87.0%) had single lesion, 38 (82.6%) had lesions occurring on the lower limb, and 26 (56.5%) presented as advanced ulcer lesions that are more than 15cm in diameter (category III lesion). The overall median (IQR) healing time was 109 (60, 146) days. The median healing time did not differ by gender, age group, HIV status or patient classification (P >0.05). However, the median healing time for patients with limitation of movement at diagnosis was 146 days, compared with 69 days for patients without limitation of movement at diagnosis (P = 0.028). Also, the median healing time was significantly associated with duration of the BU illness (P = 0.009).Conclusions: In Nigerian patients with BU, the time to complete healing of lesions is generally long. We found that duration of BU illness and having a limitation of movement at diagnosis were associated with longer healing time.
Published: 2022

6. Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017

Author: Kyu, Hh, Abate, D, Abate, Kh, Abay, Sm, Abbafati, C, Abbasi, N, Abbastabar, H, Abd-Allah, F, Abdela, J, Abdelalim, A, Abdollahpour, I, Abdulkader, Rs, Abebe, M, Abebe, Z, Abil, Oz, Aboyans, V, Abrham, Ar, Abu-Raddad, Lj, Abu-Rmeileh, Nme, Accrombessi, Mmk, Acharya, D, Acharya, P, Ackerman, In, Adamu, Aa, Adebayo, Om, Adekanmbi, V, Ademi, Z, Adetokunboh, Oo, Adib, Mg, Adsuar, Jc, Afanvi, Ka, Afarideh, M, Afshin, A, Agarwal, G, Agesa, Km, Aggarwal, R, Aghayan, Sa, Agrawal, A, Ahmadi, A, Ahmadi, M, Ahmadieh, H, Ahmed, Mb, Ahmed, S, Aichour, An, Aichour, I, Aichour, Mte, Akinyemiju, T, Akseer, N, Al-Aly, Z, Al-Eyadhy, A, Al-Mekhlafi, Hm, Al-Raddadi, Rm, Alahdab, F, Alam, K, Alam, T, Alashi, A, Alavian, Sm, Alene, Ka, Alijanzadeh, M, Alizadeh-Navaei, R, Aljunid, Sm, Alkerwi, A, Alla, F, Allebeck, P, Alonso, J, Alsharif, U, Altirkawi, K, Alvis-Guzman, N, Aminde, Ln, Amini, E, Amiresmaili, M, Ammar, W, Amoako, Ya, Anber, Nh, Andrei, Cl, Androudi, S, Animut, Md, Anjomshoa, M, Ansha, Mg, Antonio, Cat, Anwari, P, Arabloo, J, Aremu, O, Ärnlöv, J, Arora, A, Arora, M, Artaman, A, Aryal, Kk, Asayesh, H, Ataro, Z, Ausloos, M, Avila-Burgos, L, Avokpaho, Efga, Awasthi, A, Ayala, Quintanilla, Ayer, R, Azzopardi, Ps, Babazadeh, A, Badali, H, Balakrishnan, K, Bali, Ag, Banach, M, Banoub, Jam, Barac, A, Barboza, Ma, Barker-Collo, Sl, Bärnighausen, Tw, Barquera, S, Barrero, Lh, Bazargan-Hejazi, S, Bedi, N, Beghi, E, Behzadifar, M, Bekele, Bb, Bekru, Et, Belachew, Ab, Belay, Ya, Bell, Ml, Bello, Ak, Bennett, Da, Bensenor, Im, Berhane, A, Bernabe, E, Bernstein, Rs, Beuran, M, Beyranvand, T, Bhala, N, Bhatt, S, Bhaumik, S, Bhutta, Za, Biadgo, B, Biehl, Mh, Bijani, A, Bikbov, B, Bilano, V, Bililign, N, Bin, Sayeed, Bisanzio, D, Bjørge, T, Bleyer, A, Bobasa, Em, Bou-Orm, Ir, Boufous, S, Bourne, R, Brady, Oj, Brant, Lc, Brayne, C, Brazinova, A, Breitborde, Njk, Brenner, H, Briant, Ps, Briko, An, Britton, G, Brugha, T, Buchbinder, R, Busse, R, Butt, Za, Cahuana-Hurtado, L, Campuzano, Rincon, Cano, J, Cárdenas, R, Carrero, Jj, Carter, A, Carvalho, F, Castañeda-Orjuela, Ca, Castillo, Rivas, J, Castro, F, Catalá-López, F, Cercy, Km, Cerin, E, Chaiah, Y, Chang, Jc, Charlson, Fj, Chattu, Vk, Chiang, Pp, Chitheer, A, Choi, Jj, Christensen, H, Christopher, Dj, Chung, Sc, Cicuttini, Fm, Cirillo, Massimo, Collado-Mateo, D, Cooper, C, Cortesi, Pa, Cortinovis, M, Cousin, E, Criqui, Mh, Cromwell, Ea, Cross, M, Crump, Ja, Daba, Ak, Dachew, Ba, Dadi, Af, Dandona, L, Dandona, R, Dargan, Pi, Daryani, A, Das, Gupta, Das, R, Neves, J, Dasa, Tt, Davitoiu, Dv, De, La, Hoz, Fp, Leo, De, D, De, Neve, Jw, Steur, De, H, Degefa, Mg, Degenhardt, L, Deiparine, S, Demoz, Gt, Denova-Gutiérrez, E, Deribe, K, Dervenis, N, Des, Jarlais, Dey, S, Dharmaratne, Sd, Dhimal, M, Dinberu, Mt, Dirac, Ma, Djalalinia, S, Doan, L, Dokova, K, Doku, Dt, Dorsey, Er, Doyle, Ke, Driscoll, Tr, Dubey, M, Dubljanin, E, Duken, Ee, Duncan, Bb, Duraes, Ar, Ebrahimi, H, Ebrahimpour, S, Echko, Mm, Edessa, D, Edvardsson, D, Effiong, A, Eggen, Ae, Ehrlich, Jr, Bcheraoui, El, C, El-Khatib, Z, Elyazar, Irf, Enayati, A, Endalifer, Ml, Endries, Ay, Er, B, Erskine, He, Eskandarieh, S, Esteghamati, A, Esteghamati, S, Fakhim, H, Faramarzi, M, Fareed, M, Farhadi, F, Farid, Ta, Farinha, Cses, Farioli, A, Faro, A, Farzadfar, F, Fazaeli, Aa, Feigin, Vl, Fentahun, N, Fereshtehnejad, Sm, Fernandes, E, Fernandes, Jc, Ferrari, Aj, Ferreira, Ml, Filip, I, Fischer, F, Fitzmaurice, C, Foigt, Na, Foreman, Kj, Frank, Td, Fukumoto, T, Fullman, N, Fürst, T, Furtado, Jm, Gakidou, E, Gall, S, Gallus, S, Ganji, M, Garcia-Basteiro, Al, Gardner, Wm, Gebre, Ak, Gebremedhin, At, Gebremichael, Tg, Gelano, Tf, Geleijnse, Jm, Genova-Maleras, R, Geramo, Ycd, Gething, Pw, Gezae, Ke, Ghadami, Mr, Ghadiri, K, Ghasemi-Kasman, M, Ghimire, M, Ghoshal, Ag, Gill, Ps, Gill, Tk, Ginawi, Ia, Giussani, G, Gnedovskaya, Ev, Goldberg, Em, Goli, S, Gómez-Dantés, H, Gona, Pn, Gopalani, Sv, Gorman, Tm, Goulart, Ac, Goulart, Bng, Grada, A, Grosso, G, Gugnani, Hc, Guillemin, F, Guo, Y, Gupta, Pc, Gupta, R, Gupta, T, Gutiérrez, Ra, Gyawali, B, Haagsma, Ja, Hachinski, V, Hafezi-Nejad, N, Haghparast, Bidgoli, Hagos, Tb, Hailegiyorgis, Tt, Haj-Mirzaian, A, Hamadeh, Rr, Hamidi, S, Handal, Aj, Hankey, Gj, Hao, Y, Harb, Hl, Harikrishnan, S, Haririan, H, Haro, Jm, Hassankhani, H, Hassen, Hy, Havmoeller, R, Hay, Rj, Hay, Si, Hedayatizadeh-Omran, A, Heibati, B, Hendrie, D, Henok, A, Heredia-Pi, I, Herteliu, C, Heydarpour, F, Heydarpour, P, Hibstu, Dt, Hoek, Hw, Hoffman, Hj, Hole, Mk, Homaie, Rad, E, Hoogar, P, Hosgood, Hd, Hosseini, Sm, Hosseinzadeh, M, Hostiuc, M, Hostiuc, S, Hotez, Pj, Hoy, Dg, Hsairi, M, Htet, As, Huang, Jj, Iburg, Km, Ikeda, Ct, Ilesanmi, Os, Irvani, Ssn, Irvine, Cms, Islam, Sms, Islami, F, Jacobsen, Kh, Jahangiry, L, Jahanmehr, N, Jain, Sk, Jakovljevic, M, James, Sl, Jayatilleke, Au, Jeemon, P, Jha, Rp, Jha, V, Js, Ji, Johnson, Co, Jonas, Jb, Jonnagaddala, J, Jorjoran, Shushtari, Z, Joshi, A, Jozwiak, Jj, Jungari, Sb, Jürisson, M, Kabir, Z, Kadel, R, Kahsay, A, Kalani, R, Kanchan, T, Kar, C, Karami, M, Karami, Matin, B, Karch, A, Karema, C, Karimi, N, Karimi, Sm, Kasaeian, A, Kassa, Dh, Kassa, Gm, Kassa, Td, Kassebaum, Nj, Katikireddi, Sv, Kaul, A, Kawakami, N, Kazemi, Z, Karyani, Ak, Keighobadi, Mm, Keiyoro, Pn, Kemmer, L, Kemp, Gr, Kengne, Ap, Keren, A, Khader, Ys, Khafaei, B, Khafaie, Ma, Khajavi, A, Khalid, N, Khalil, Ia, Khan, Ea, Khan, Ms, Khan, Ma, Khang, Yh, Khater, Mm, Khazaei, M, Khoja, At, Khosravi, A, Khosravi, Mh, Kiadaliri, Aa, Kidanemariam, Zt, Kiirithio, Dn, Kim, Ci, Kim, D, Kim, Ye, Kim, Yj, Kimokoti, Rw, Kinfu, Y, Kisa, A, Kissimova-Skarbek, K, Knudsen, Aks, Kocarnik, Jm, Kochhar, S, Kokubo, Y, Kolola, T, Kopec, Ja, Kosen, S, Kotsakis, Ga, Koul, Pa, Koyanagi, A, Krishan, K, Krishnaswami, S, Krohn, Kj, Kuate, Defo, Kucuk, B, Bicer, B, Kumar, Ga, Kumar, M, Kuzin, I, Lad, Dp, Lad, Sd, Lafranconi, A, Lalloo, R, Lallukka, T, Lami, Fh, Lang, Jj, Langan, Sm, Lansingh, Vc, Latifi, A, Lau, Km, Lazarus, Jv, Leasher, Jl, Ledesma, Jr, Lee, Ph, Leigh, J, Leili, M, Leshargie, Ct, Leung, J, Levi, M, Lewycka, S, Li, S, Li, Y, Liang, X, Liao, Y, Liben, Ml, Lim, Ll, Lim, Ss, Limenih, Ma, Linn, S, Liu, S, Looker, Kj, Lopez, Ad, Lorkowski, S, Lotufo, Pa, Lozano, R, Lucas, Tcd, Lunevicius, R, Lyons, Ra, Ma, S, Macarayan, Erk, Mackay, Mt, Maddison, Er, Madotto, F, Maghavani, Dp, Mai, Ht, Majdan, M, Majdzadeh, R, Majeed, A, Malekzadeh, R, Malta, Dc, Mamun, Aa, Manda, Al, Manguerra, H, Mansournia, Ma, Mantilla, Herrera, Mantovani, Lg, Maravilla, Jc, Marcenes, W, Marks, A, Martins-Melo, Fr, Martopullo, I, März, W, Marzan, Mb, Massano, J, Massenburg, Bb, Mathur, Mr, Maulik, Pk, Mazidi, M, Mcalinden, C, Mcgrath, Jj, Mckee, M, Mcmahon, Bj, Mehata, S, Mehrotra, R, Mehta, Km, Mehta, V, Mejia-Rodriguez, F, Mekonen, T, Melese, A, Melku, M, Memiah, Ptn, Memish, Za, Mendoza, W, Mengistu, G, Mensah, Ga, Mereta, St, Meretoja, A, Meretoja, Tj, Mestrovic, T, Miazgowski, B, Miazgowski, T, Millear, Ai, Miller, Tr, Mini, Gk, Mirarefin, M, Mirica, A, Mirrakhimov, Em, Misganaw, At, Mitchell, Pb, Mitiku, H, Moazen, B, Mohajer, B, Mohammad, Ka, Mohammadi, M, Mohammadifard, N, Mohammadnia-Afrouzi, M, Mohammed, Ma, Mohammed, S, Mohebi, F, Mokdad, Ah, Molokhia, M, Monasta, L, Montañez, Jc, Moosazadeh, M, Moradi, G, Moradi, M, Moradi-Lakeh, M, Moradinazar, M, Moraga, P, Morawska, L, Moreno, Velásquez, I, Morgado-Da-Costa, J, Morrison, Sd, Moschos, Mm, Mousavi, Sm, Mruts, Kb, Muche, Aa, Muchie, Kf, Mueller, Uo, Muhammed, Os, Mukhopadhyay, S, Muller, K, Mumford, Je, Murthy, Gvs, Musa, Ki, Mustafa, G, Nabhan, Af, Nagata, C, Nagel, G, Naghavi, M, Naheed, A, Nahvijou, A, Naik, G, Najafi, F, Nam, Hs, Nangia, V, Nansseu, Jr, Neamati, N, Negoi, I, Negoi, Ri, Neupane, S, Newton, Crj, Ngunjiri, Jw, Nguyen, Aq, Nguyen, G, Nguyen, Ht, Nguyen, Hlt, Nguyen, Lh, Nguyen, M, Nguyen, Nb, Nguyen, Sh, Nichols, E, Ningrum, Dna, Nixon, Mr, Nomura, S, Noroozi, M, Norrving, B, Noubiap, Jj, Nouri, Hr, Shiadeh, Mn, Nowroozi, Mr, Nsoesie, Eo, Nyasulu, Ps, Odell, Cm, Ofori-Asenso, R, Ogbo, Fa, Ih, Oh, Oladimeji, O, Olagunju, At, Olagunju, To, Olivares, Pr, Olsen, He, Olusanya, Bo, Olusanya, Jo, Ong, Kl, Ong, Sk, Oren, E, Ortiz, A, Ota, E, Otstavnov, Ss, Øverland, S, Owolabi, Mo, P, A, M, Pacella, R, Pakhare, Ap, Pakpour, Ah, Pana, A, Panda-Jonas, S, Park, Ek, Park, J, Parry, Cdh, Parsian, H, Pasdar, Y, Patel, S, Patil, St, Patle, A, Patton, Gc, Paturi, Vr, Paudel, D, Paulson, Kr, Pearce, N, Pereira, A, Pereira, Dm, Perico, N, Pesudovs, K, Petzold, M, Pham, Hq, Phillips, Mr, Pigott, Dm, Pillay, Jd, Piradov, Ma, Pirsaheb, M, Pishgar, F, Plana-Ripoll, O, Polinder, S, Popova, S, Postma, Mj, Pourshams, A, Poustchi, H, Prabhakaran, D, Prakash, S, Prakash, V, Prasad, N, Purcell, Ca, Qorbani, M, Quistberg, Da, Radfar, A, Rafay, A, Rafiei, A, Rahim, F, Rahimi, K, Rahimi, Z, Rahimi-Movaghar, A, Rahimi-Movaghar, V, Rahman, M, Rahman, Mhu, Rahman, Ma, Rahman, Su, Rai, Rk, Rajati, F, Ranjan, P, Rao, Pc, Rasella, D, Rawaf, Dl, Rawaf, S, Reddy, Ks, Reiner, Rc, Reitsma, Mb, Remuzzi, G, Renzaho, Amn, Resnikoff, S, Rezaei, S, Rezai, Ms, Ribeiro, Alp, Roberts, Nls, Robinson, Sr, Roever, L, Ronfani, L, Roshandel, G, Rostami, A, Roth, Ga, Rothenbacher, D, Rubagotti, E, Sachdev, Ps, Sadat, N, Sadeghi, E, Saeedi, Moghaddam, S, Safari, H, Safari, Y, Safari-Faramani, R, Safdarian, M, Safi, S, Safiri, S, Sagar, R, Sahebkar, A, Sahraian, Ma, Sajadi, Hs, Salam, N, Salama, Js, Salamati, P, Saleem, Z, Salimi, Y, Salimzadeh, H, Salomon, Ja, Salvi, Ss, Salz, I, Samy, Am, Sanabria, J, Sanchez-Niño, Md, Santomauro, Df, Santos, Is, Santos, Jv, Santric, Milicevic, Sao, Mm, Jose, Bp, Sardana, M, Sarker, Ar, Sarmiento-Suárez, R, Sarrafzadegan, N, Sartorius, B, Sarvi, S, Sathian, B, Satpathy, M, Sawant, Ar, Sawhney, M, Saxena, S, Schaeffner, E, Schmidt, Mi, Schneider, Ijc, Schutte, Ae, Schwebel, Dc, Schwendicke, F, Scott, Jg, Sekerija, M, Sepanlou, Sg, Serván-Mori, E, Seyedmousavi, S, Shabaninejad, H, Shafieesabet, A, Shahbazi, M, Shaheen, Aa, Shaikh, Ma, Shams-Beyranvand, M, Shamsi, M, Sharafi, H, Sharafi, K, Sharif, M, Sharif-Alhoseini, M, Sharma, J, Sharma, R, She, J, Sheikh, A, Shi, P, Shibuya, K, Shiferaw, Ms, Shigematsu, M, Shiri, R, Shirkoohi, R, Shiue, I, Shokoohinia, Y, Shokraneh, F, Shoman, H, Shrime, Mg, Si, S, Siabani, S, Sibai, Am, Siddiqi, Tj, Sigfusdottir, Id, Sigurvinsdottir, R, Silva, Das, Silva, Jp, Silveira, Dga, Singam, Nsv, Singh, Ja, Singh, Np, Singh, V, Sinha, Dn, Skiadaresi, E, Skirbekk, V, Sliwa, K, Smith, Dl, Smith, M, Soares, Filho, Sobaih, Bh, Sobhani, S, Soofi, M, Sorensen, Rjd, Soyiri, In, Sposato, La, Sreeramareddy, Ct, Srinivasan, V, Stanaway, Jd, Starodubov, Vi, Stein, Dj, Steiner, C, Steiner, Tj, Stokes, Ma, Stovner, Lj, Subart, Ml, Sudaryanto, A, Sufiyan, Mb, Sulo, G, Sunguya, Bf, Sur, Pj, Sykes, Bl, Sylaja, Pn, Sylte, Do, Szoeke, Cei, Tabarés-Seisdedos, R, Tabuchi, T, Tadakamadla, Sk, Tandon, N, Tassew, Sg, Tavakkoli, M, Taveira, N, Taylor, Hr, 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Patil, Snehal T, Patle, Ajay, Patton, George C, Paturi, Vishnupriya Rao, Paudel, Deepak, Paulson, Katherine R, Pearce, Neil, Pereira, Alexandre, Pereira, David M, Perico, Norberto, Pesudovs, Konrad, Petzold, Max, Pham, Hai Quang, Phillips, Michael R, Pigott, David M, Pillay, Julian David, Piradov, Michael A, Pirsaheb, Meghdad, Pishgar, Farhad, Plana-Ripoll, Oleguer, Polinder, Suzanne, Popova, Svetlana, Postma, Maarten J, Pourshams, Akram, Poustchi, Hossein, Prabhakaran, Dorairaj, Prakash, Swayam, Prakash, V., Prasad, Narayan, Purcell, Caroline A, Qorbani, Mostafa, Quistberg, D Alex, Radfar, Amir, Rafay, Anwar, Rafiei, Alireza, Rahim, Fakher, Rahimi, Kazem, Rahimi, Zohreh, Rahimi-Movaghar, Afarin, Rahimi-Movaghar, Vafa, Rahman, Mahfuzar, Rahman, Mohammad Hifz Ur, Rahman, Muhammad Aziz, Rahman, Sajjad Ur, Rai, Rajesh Kumar, Rajati, Fatemeh, Ranjan, Prabhat, Rao, Puja C, Rasella, Davide, Rawaf, David Laith, Rawaf, Salman, Reddy, K Srinath, Reiner, Robert C, Reitsma, Marissa Bettay, 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Subjects: Male, Health Status, health statu, HALE, mortality rate, communicable disease, DALYs, Global Burden of Disease, Risk Factors, Prevalence, Medicine and Health Sciences, Singapore, OUTCOMES, disability-adjusted life year, international cooperation, Medicine (all), 11 Medical And Health Sciences, Central African Republic, newborn disease, IRON-DEFICIENCY, AIDS, priority journal, Bahrain, disease severity, Female, Quality-Adjusted Life Years, cerebrovascular accident, Ukraine, Life Sciences & Biomedicine, INTERVENTIONS, Slovakia, DISORDERS, Burundi, WEIGHTS, GBD 2017 DALYs and HALE Collaborators, Communicable Diseases, Article, STYLE, Medicine, General & Internal, Life Expectancy, General & Internal Medicine, Humans, Disabled Persons, human, Healthy Lifestyle, HALE, DALYs, global burden of disease, Mortality, Aged, Science & Technology, Mortality, Premature, HIV, ischemic heart disease, major clinical study, PREVENTION, non communicable disease, GBD, disability-adjusted life-years, age, sex factor, Socioeconomic Factors, Algeria, Federation of Bosnia and Herzegovina, lower respiratory tract infection, Wounds and Injuries, GENDER, Human medicine, trend study, chronic obstructive lung disease
Abstract: Background How long one lives, how many years of life are spent in good and poor health, and how the population's state of health and leading causes of disability change over time all have implications for policy, planning, and provision of services. We comparatively assessed the patterns and trends of healthy life expectancy (HALE), which quantifies the number of years of life expected to be lived in good health, and the complementary measure of disability-adjusted life years (DALYs), a composite measure of disease burden capturing both premature mortality and prevalence and severity of ill health, for 359 diseases and injuries for 195 countries and territories over the past 28 years. Methods We used data for age-specific mortality rates, years of life lost (YLLs) due to premature mortality, and years lived with disability (YLDs) from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 to calculate HALE and DALYs from 1990 to 2017. We calculated HALE using age-specific mortality rates and YLDs per capita for each location, age, sex, and year. We calculated DALYs for 359 causes as the sum of YLLs and YLDs. We assessed how observed HALE and DALYs differed by country and sex from expected trends based on Sociodemographic Index (SDI). We also analysed HALE by decomposing years of life gained into years spent in good health and in poor health, between 1990 and 2017, and extra years lived by females compared with males. Findings Globally, from 1990 to 2017, life expectancy at birth increased by 7.4 years (95% uncertainty interval 74-7.8), from 65.6 years (65.3-65- 8) in 1990 to 73.0 years (72.7-73.3) in 2017. The increase in years of life varied from 5.1 years (5.0-5.3) in high SDI countries to 12.0 years (11.3-12.8) in low SDI countries. Of the additional years of life expected at birth, 26.3% (20.1-33.1) were expected to be spent in poor health in high SDI countries compared with 11.7% (8.8-15.1) in low-middle SDI countries. HALE at birth increased by 6.3 years (5.9-6.7), from 57.0 years (54.6-59.1) in 1990 to 63.3 years (60.5-65.7) in 2017. The increase varied from 3.8 years (3.4-4.1) in high SDI countries to 10.5 years (9.8-11.2) in low SDI countries. Even larger variations in HALE than these were observed between countries, ranging from 1.0 year (0.4-1.7) in Saint Vincent and the Grenadines (62.4 years [59.9-64.7] in 1990 to 63.5 years [60.9-65.8] in 2017) to 23.7 years (21.9-25.6) in Eritrea (30.7 years [28.9-32.2] in 1990 to 54.4 years [51.5-57.1] in 2017). In most countries, the increase in HALE was smaller than the increase in overall life expectancy, indicating more years lived in poor health. In 180 of 195 countries and territories, females were expected to live longer than males in 2017, with extra years lived varying from 1.4 years (0.6-2.3) in Algeria to 11.9 years (10.9-12.9) in Ukraine. Of the extra years gained, the proportion spent in poor health varied largely across countries, with less than 20% of additional years spent in poor health in Bosnia and Herzegovina, Burundi, and Slovakia, whereas in Bahrain all the extra years were spent in poor health. In 2017, the highest estimate of HALE at birth was in Singapore for both females (75.8 years [72.4-78.7]) and males (72.6 years [69 " 8-75.0]) and the lowest estimates were in Central African Republic (47.0 years [43.7-50.2] for females and 42.8 years [40.1-45.6] for males). Globally, in 2017, the five leading causes of DALYs were neonatal disorders, ischaemic heart disease, stroke, lower respiratory infections, and chronic obstructive pulmonary disease. Between 1990 and 2017, age-standardised DALY rates decreased by 41.3% (38.8-43.5) for communicable diseases and by 49"8% (47.9-51.6) for neonatal disorders. For non-communicable diseases, global DALYs increased by 40.1% (36.8-43.0), although age-standardised DALY rates decreased by 18.1% (16.0-20.2). Interpretation With increasing life expectancy in most countries, the question of whether the additional years of life gained are spent in good health or poor health has been increasingly relevant because of the potential policy implications, such as health-care provisions and extending retirement ages. In some locations, a large proportion of those additional years are spent in poor health. Large inequalities in HALE and disease burden exist across countries in different SDI quintiles and between sexes. The burden of disabling conditions has serious implications for health system planning and health-related expenditures. Despite the progress made in reducing the burden of communicable diseases and neonatal disorders in low S DI countries, the speed of this progress could be increased by scaling up proven interventions. The global trends among non-communicable diseases indicate that more effort is needed to maximise HALE, such as risk prevention and attention to upstream determinants of health. Copyright (C) 2018 The Author(s). Published by Elsevier Ltd.
Published: 2018

7. International prevalence and risk factors evaluation for drug-resistant Streptococcus pneumoniae pneumonia

Author: Aliberti, S, Cook, GS, Babu, BL, Reyes, LF, Rodriguez, AH, Sanz, F, Soni, NJ, Anzueto, A, Faverio, P, Sadud, RF, Muhammad, I, Prat, C, Vendrell, E, Neves, J, Kaimakamis, E, Feneley, A, Swarnakar, R, Franzetti, F, Carugati, M, Morosi, M, Monge, E, Restrepo, MI, Aruj, PK, Attorri, S, Barimboim, E, Caeiro, JP, Garzon, MI, Cambursano, VH, Ceccato, A, Chertcoff, J, Lascar, F, Di Tulio, F, Diaz, AC, de Vedia, L, Ganaha, MC, Lambert, S, Lopardo, G, Lopez, V, Luna, CM, Malberti, AG, Morcillo, N, Tartara, S, Pensotti, C, Pereyra, B, Scapellato, PG, Stagnaro, JP, Shah, S, Lotsch, F, Thalhammer, F, Anseeuw, K, Francois, CA, Van Braeckel, E, Vincent, JL, Djimon, MZ, Bashi, J, Dodo, R, Nouer, SA, Chipev, P, Encheva, M, Miteva, D, Petkova, D, Balkissou, AD, Yone, EWP, Ngahane, BHM, Shen, N, Xu, JF, Rico, CAB, Buitrago, R, Paternina, FJP, Ntumba, JMK, Carevic, VV, Jakopovic, M, Jankovic, M, Matkovic, Z, Mitrecic, I, Jacobsson, MLB, Christensen, AB, Bodtger, UCH, Meyer, CN, Jensen, AV, Baunbaek-knudsen, G, Petersen, PT, Andersen, S, Abd El-Wahhab, IES, Morsy, NE, Shafiek, H, Sobh, E, Abdulsemed, KA, Bertrand, F, Brun-Buisson, C, de Montmollin, E, Fartoukh, M, Messika, J, Tattevin, P, Khoury, A, Ebruke, B, Dreher, M, Kolditz, M, Meisinger, M, Pletz, MW, Hagel, S, Rupp, J, Schaberg, T, Spielmanns, M, Creutz, P, Suttorp, N, Siaw-Lartey, B, Dimakou, K, Papapetrou, D, Tsigou, E, Ampazis, D, Bhatia, M, Dhar, R, D'Souza, G, Garg, R, Koul, PA, Mahesh, PA, Jayaraj, BS, Narayan, KV, Udnur, HB, Krishnamurthy, SB, Kant, S, Limaye, S, Salvi, S, Golshani, K, Keatings, VM, Martin-Loeches, I, Maor, Y, Strahilevitz, J, Battaglia, S, Carrabba, M, Ceriana, P, Confalonieri, M, Monforte, AD, Del Prato, B, De Rosa, M, Fantini, R, Fiorentino, G, Gammino, MA, Menzella, F, Milani, G, Nava, S, Palmiero, G, Petrino, R, Gabrielli, B, Rossi, P, Sorino, C, Steinhilber, G, Zanforlin, A, Carone, M, Patella, V, Scarlata, S, Comel, A, Kurahashi, K, Bacha, ZA, Ugalde, DB, Zuniga, OC, Villegas, JF, Medenica, M, van de Garde, EMW, Mihsra, DR, Shrestha, P, Ridgeon, E, Awokola, BI, Nwankwo, ONO, Olufunlola, AB, Olumide, S, Ukwaja, KN, Irfan, M, Minarowski, L, Szymon, S, Froes, F, Leuschner, P, Meireles, M, Ferrao, C, Ravara, SB, Brocovschii, V, Ion, C, Rusu, D, Toma, C, Chirita, D, Dorobat, CM, Birkun, A, Kaluzhenina, A, Almotairi, A, Bukhary, ZAA, Edathodu, J, Fathy, A, Enani, AMA, Mohamed, NE, Memon, JU, Bella, A, Bogdanovic, N, Milenkovic, B, Pesut, D, Borderias, L, Garcia, NMB, Alarcon, HC, Cilloniz, C, Torres, A, Diaz-Brito, V, Casas, X, Gonzalez, AE, Fernandez-Almira, ML, Gallego, M, Gaspar-Garcia, I, del Castillo, JG, Victoria, PJ, Martinez, EL, de Molina, RM, Marcos, PJ, Menendez, R, Pando-Sandoval, A, Aymerich, CP, de la Torre, AL, Garcia-Olive, I, Rello, J, Moyano, S, Sibila, O, Rodrigo-Troyano, A, Sole-Violan, J, Uranga, A, van Boven, JFM, Torra, EV, Pujol, JA, Feldman, C, Yum, HK, Fiogbe, AA, Yangui, F, Bilaceroglu, S, Dalar, L, Yilmaz, U, Bogomolov, A, Elahi, N, Dhasmana, DJ, Ions, R, Skeemer, J, Woltmann, G, Hancock, C, Hill, AT, Rudran, B, Ruiz-Buitrago, S, Campbell, M, Whitaker, P, Youzguin, A, Singanayagam, A, Allen, KS, Brito, V, Dietz, J, Dysart, CE, Kellie, SM, Franco-Sadud, RA, Meier, G, Gaga, M, Holland, TL, Bergin, SP, Kheir, F, Landmeier, M, Lois, M, Nair, GB, Patel, H, Reyes, K, Rodriguez-Cintron, W, Saito, S, Noda, J, Hinojosa, CI, Levine, SM, Angel, LF, Whitlow, KS, Hipskind, J, Sukhija, K, Totten, V, Wunderink, RG, Shah, RD, Mateyo, KJ, Noriega, L, Alvarado, E, Aman, M, Labra, L, Aliberti, S, Cook, G, Babu, B, Reyes, L, H. Rodriguez, A, Sanz, F, Soni, N, Anzueto, A, Faverio, P, Sadud, R, Muhammad, I, Prat, C, Vendrell, E, Neves, J, Kaimakamis, E, Feneley, A, Swarnakar, R, Franzetti, F, Carugati, M, Morosi, M, Monge, E, Restrepo, M, Aliberti, S., Cook, G. S., Babu, B. L., Reyes, L. F., Rodriguez, A. H., Sanz, F., Soni, N. J., Anzueto, A., Faverio, P., Sadud, R. F., Muhammad, I., Prat, C., Vendrell, E., Neves, J., Kaimakamis, E., Feneley, A., Swarnakar, R., Franzetti, F., Carugati, M., Morosi, M., Monge, E., Restrepo, M. I., Aruj, P. K., Attorri, S., Barimboim, E., Caeiro, J. P., Garzon, M. I., Cambursano, V. H., Ceccato, A., Chertcoff, J., Lascar, F., Di Tulio, F., Diaz, A. C., de Vedia, L., Ganaha, M. C., Lambert, S., Lopardo, G., Luna, C. M., Malberti, A. G., Morcillo, N., Tartara, S., Pensotti, C., Pereyra, B., Scapellato, P. G., Stagnaro, J. P., Shah, S., Lotsch, F., Thalhammer, F., Anseeuw, K., Francois, C. A., Van Braeckel, E., Vincent, J. L., Djimon, M. Z., Bashi, J., Dodo, R., Nouer, S. A., Chipev, P., Encheva, M., Miteva, D., Petkova, D., Balkissou, A. D., Yone, E. W. P., Ngahane, B. H. M., Shen, N., Xu, J. -F., Rico, C. A. B., Buitrago, R., Paternina, F. J. P., Ntumba, J. -M. K., Carevic, V. V., Jakopovic, M., Jankovic, M., Matkovic, Z., Mitrecic, I., Jacobsson, M. -L. B., Christensen, A. B., Bodtger, U. C. H., Meyer, C. N., Jensen, A. V., Baunbaek-Knudsen, G., Petersen, P. T., Andersen, S., El-Wahhab, I. E. -S. A., Morsy, N. E., Shafiek, H., Sobh, E., Abdulsemed, K. A., Bertrand, F., Brun-Buisson, C., de Montmollin, E., Fartoukh, M., Messika, J., Tattevin, P., Khoury, A., Ebruke, B., Dreher, M., Kolditz, M., Meisinger, M., Pletz, M. W., Hagel, S., Rupp, J., Schaberg, T., Spielmanns, M., Creutz, P., Suttorp, N., Siaw-Lartey, B., Dimakou, K., Papapetrou, D., Tsigou, E., Ampazis, D., Bhatia, M., Dhar, R., D'Souza, G., Garg, R., Koul, P. A., Mahesh, P. A., Jayaraj, B. S., Narayan, K. V., Udnur, H. B., Krishnamurthy, S. B., Kant, S., Limaye, S., Salvi, S., Golshani, K., Keatings, V. M., Martin-Loeches, I., Maor, Y., Strahilevitz, J., Battaglia, S., Carrabba, M., Ceriana, P., Confalonieri, M., D'Arminio Monforte, A., Del Prato, B., De Rosa, M., Fantini, R., Fiorentino, G., Gammino, M. A., Menzella, F., Milani, G., Nava, S., Palmiero, G., Petrino, R., Gabrielli, B., Rossi, P., Sorino, C., Steinhilber, G., Zanforlin, A., Carone, M., Patella, V., Scarlata, S., Comel, A., Kurahashi, K., Bacha, Z. A., Ugalde, D. B., Zuniga, O. C., Villegas, J. F., Medenica, M., van de Garde, E. M. W., Mihsra, D. R., Shrestha, P., Ridgeon, E., Awokola, B. I., Nwankwo, O. N. O., Olufunlola, A. B., Olumide, S., Ukwaja, K. N., Irfan, M., Minarowski, L., Szymon, S., Froes, F., Leuschner, P., Meireles, M., Ferrao, C., Ravara, S. B., Brocovschii, V., Ion, C., Rusu, D., Toma, C., Chirita, D., Dorobat, C. M., Birkun, A., Kaluzhenina, A., Almotairi, A., Bukhary, Z. A. A., Edathodu, J., Fathy, A., Enani, A. M. A., Mohamed, N. E., Memon, J. U., Bella, A., Bogdanovic, N., Milenkovic, B., Pesut, D., Borderias, L., Garcia, N. M. B., Alarcon, H. C., Cilloniz, C., Torres, A., Diaz-Brito, V., Casas, X., Gonzalez, A. E., Fernandez-Almira, M. L., Gallego, M., Gaspar-Garcia, I., Del Castillo, J. G., Victoria, P. J., Martinez, E. L., de Molina, R. M., Marcos, P. J., Menendez, R., Pando-Sandoval, A., Aymerich, C. P., de la Torre, A. L., Garcia-Olive, I., Rello, J., Moyano, S., Sibila, O., Rodrigo-Troyano, A., Sole-Violan, J., Uranga, A., van Boven, J. F. M., Torra, E. V., Pujol, J. A., Feldman, C., Yum, H. K., Fiogbe, A. A., Yangui, F., Bilaceroglu, S., Dalar, L., Yilmaz, U., Bogomolov, A., Elahi, N., Dhasmana, D. J., Ions, R., Skeemer, J., Woltmann, G., Hancock, C., Hill, A. T., Rudran, B., Ruiz-Buitrago, S., Campbell, M., Whitaker, P., Youzguin, A., Singanayagam, A., Allen, K. S., Brito, V., Dietz, J., Dysart, C. E., Kellie, S. M., Franco-Sadud, R. A., Meier, G., Gaga, M., Holland, T. L., Bergin, S. P., Kheir, F., Landmeier, M., Lois, M., Nair, G. B., Patel, H., Reyes, K., Rodriguez-Cintron, W., Saito, S., Noda, J., Hinojosa, C. I., Levine, S. M., Angel, L. F., Whitlow, K. S., Hipskind, J., Sukhija, K., Totten, V., Wunderink, R. G., Shah, R. D., Mateyo, K. J., Noriega, L., Alvarado, E., Aman, M., Labra, L., Aliberti S., Cook G.S., Babu B.L., Reyes L.F., Rodriguez A.H., Sanz F., Soni N.J., Anzueto A., Faverio P., Sadud R.F., Muhammad I., Prat C., Vendrell E., Neves J., Kaimakamis E., Feneley A., Swarnakar R., Franzetti F., Carugati M., Morosi M., Monge E., Restrepo M.I., Aruj P.K., Attorri S., Barimboim E., Caeiro J.P., Garzon M.I., Cambursano V.H., Ceccato A., Chertcoff J., Lascar F., Di Tulio F., Diaz A.C., de Vedia L., Ganaha M.C., Lambert S., Lopardo G., Luna C.M., Malberti A.G., Morcillo N., Tartara S., Pensotti C., Pereyra B., Scapellato P.G., Stagnaro J.P., Shah S., Lotsch F., Thalhammer F., Anseeuw K., Francois C.A., Van Braeckel E., Vincent J.L., Djimon M.Z., Bashi J., Dodo R., Nouer S.A., Chipev P., Encheva M., Miteva D., Petkova D., Balkissou A.D., Yone E.W.P., Ngahane B.H.M., Shen N., Xu J.-F., Rico C.A.B., Buitrago R., Paternina F.J.P., Ntumba J.-M.K., Carevic V.V., Jakopovic M., Jankovic M., Matkovic Z., Mitrecic I., Jacobsson M.-L.B., Christensen A.B., Bodtger U.C.H., Meyer C.N., Jensen A.V., Baunbaek-Knudsen G., Petersen P.T., Andersen S., El-Wahhab I.E.-S.A., Morsy N.E., Shafiek H., Sobh E., Abdulsemed K.A., Bertrand F., Brun-Buisson C., de Montmollin E., Fartoukh M., Messika J., Tattevin P., Khoury A., Ebruke B., Dreher M., Kolditz M., Meisinger M., Pletz M.W., Hagel S., Rupp J., Schaberg T., Spielmanns M., Creutz P., Suttorp N., Siaw-Lartey B., Dimakou K., Papapetrou D., Tsigou E., Ampazis D., Bhatia M., Dhar R., D'souza G., Garg R., Koul P.A., Mahesh P.A., Jayaraj B.S., Narayan K.V., Udnur H.B., Krishnamurthy S.B., Kant S., Limaye S., Salvi S., Golshani K., Keatings V.M., Martin-Loeches I., Maor Y., Strahilevitz J., Battaglia S., Carrabba M., Ceriana P., Confalonieri M., D'Arminio Monforte A., Del Prato B., De Rosa M., Fantini R., Fiorentino G., Gammino M.A., Menzella F., Milani G., Nava S., Palmiero G., Petrino R., Gabrielli B., Rossi P., Sorino C., Steinhilber G., Zanforlin A., Carone M., Patella V., Scarlata S., Comel A., Kurahashi K., Bacha Z.A., Ugalde D.B., Zuniga O.C., Villegas J.F., Medenica M., van de Garde E.M.W., Mihsra D.R., Shrestha P., Ridgeon E., Awokola B.I., Nwankwo O.N.O., Olufunlola A.B., Olumide S., Ukwaja K.N., Irfan M., Minarowski L., Szymon S., Froes F., Leuschner P., Meireles M., Ferrao C., Ravara S.B., Brocovschii V., Ion C., Rusu D., Toma C., Chirita D., Dorobat C.M., Birkun A., Kaluzhenina A., Almotairi A., Bukhary Z.A.A., Edathodu J., Fathy A., Enani A.M.A., Mohamed N.E., Memon J.U., Bella A., Bogdanovic N., Milenkovic B., Pesut D., Borderias L., Garcia N.M.B., Alarcon H.C., Cilloniz C., Torres A., Diaz-Brito V., Casas X., Gonzalez A.E., Fernandez-Almira M.L., Gallego M., Gaspar-Garcia I., Del Castillo J.G., Victoria P.J., Martinez E.L., de Molina R.M., Marcos P.J., Menendez R., Pando-Sandoval A., Aymerich C.P., de la Torre A.L., Garcia-Olive I., Rello J., Moyano S., Sibila O., Rodrigo-Troyano A., Sole-Violan J., Uranga A., van Boven J.F.M., Torra E.V., Pujol J.A., Feldman C., Yum H.K., Fiogbe A.A., Yangui F., Bilaceroglu S., Dalar L., Yilmaz U., Bogomolov A., Elahi N., Dhasmana D.J., Ions R., Skeemer J., Woltmann G., Hancock C., Hill A.T., Rudran B., Ruiz-Buitrago S., Campbell M., Whitaker P., Youzguin A., Singanayagam A., Allen K.S., Brito V., Dietz J., Dysart C.E., Kellie S.M., Franco-Sadud R.A., Meier G., Gaga M., Holland T.L., Bergin S.P., Kheir F., Landmeier M., Lois M., Nair G.B., Patel H., Reyes K., Rodriguez-Cintron W., Saito S., Noda J., Hinojosa C.I., Levine S.M., Angel L.F., Whitlow K.S., Hipskind J., Sukhija K., Totten V., Wunderink R.G., Shah R.D., Mateyo K.J., Noriega L., Alvarado E., Aman M., and Labra L.
Subjects: 0301 basic medicine, Male, Streptococcus pneumonia, antibiotic resistance, Internationality, sputum examination, bronchiectasis, very elderly, Antibiotics, Prevalence, Drug resistance, medicine.disease_cause, Logistic regression, Global Health, Community-Acquired Infections/epidemiology, lung lavage, 0302 clinical medicine, Community-acquired pneumonia, Cost of Illness, Risk Factors, drug resistant Streptococcus pneumoniae pneumonia, 030212 general & internal medicine, Microbial drug resistant, Aged, 80 and over, adult, international cooperation, drug effect, Middle Aged, influenza vaccination, Anti-Bacterial Agents, antiinfective agent, Europe, Community-Acquired Infections, Hospitalization, Global burden of disease, Streptococcus pneumoniae, Infectious Diseases, risk factor, bacterium identification, Female, community acquired infection, influenza, liver disease, pneumococcal vaccination, Pneumococcal infection, hospitalization, medicine.drug, Microbiology (medical), medicine.medical_specialty, Asia, medicine.drug_class, 030106 microbiology, Settore MED/10 - Malattie Dell'Apparato Respiratorio, Article, Anti-Bacterial Agents/pharmacology, 03 medical and health sciences, Internal medicine, Drug Resistance, Bacterial, Pneumonia, Pneumococcal/epidemiology, medicine, Humans, controlled study, human, tetracycline, Hospitalization/statistics & numerical data, Aged, levofloxacin, nonhuman, business.industry, disease association, microbiology, community acquired pneumonia, macrolide, Pneumonia, asthma, South America, Pneumonia, Pneumococcal, vaccination, medicine.disease, major clinical study, antibiotic sensitivity, penicillin derivative, Penicillin, Streptococcus pneumoniae/drug effects, blood examination, Africa, North America, microbiological examination, business
Abstract: Objective: Streptococcus pneumoniae is the most frequent bacterial pathogen isolated in subjects with Community-acquired pneumonia (CAP) worldwide. Limited data are available regarding the current global burden and risk factors associated with drug-resistant Streptococcus pneumoniae (DRSP) in CAP subjects. We assessed the multinational prevalence and risk factors for DRSP-CAP in a multinational point-prevalence study. Design: The prevalence of DRSP-CAP was assessed by identification of DRSP in blood or respiratory samples among adults hospitalized with CAP in 54 countries. Prevalence and risk factors were compared among subjects that had microbiological testing and antibiotic susceptibility data. Multivariate logistic regressions were used to identify risk factors independently associated with DRSP-CAP. Results: 3,193 subjects were included in the study. The global prevalence of DRSP-CAP was 1.3% and continental prevalence rates were 7.0% in Africa, 1.2% in Asia, and 1.0% in South America, Europe, and North America, respectively. Macrolide resistance was most frequently identified in subjects with DRSP-CAP (0.6%) followed by penicillin resistance (0.5%). Subjects in Africa were more likely to have DRSP-CAP (OR: 7.6; 95% CI: 3.34-15.35, p < 0.001) when compared to centres representing other continents. Conclusions: This multinational point-prevalence study found a low global prevalence of DRSP-CAP that may impact guideline development and antimicrobial policies. Published by Elsevier Ltd on behalf of The British Infection Association.
Published: 2019

8. Diseases, Injuries, and Risk Factors in Child and Adolescent Health, 1990 to 2017: Findings From the Global Burden of Diseases, Injuries, and Risk Factors 2017 Study

Author: Kassebaum, NJ, Reiner, RC, Olsen, HE, Ikeda, CT, Echko, MM, Ballestreros, KE, Manguerra, H, Martopullo, I, Millear, A, Shields, C, Smith, A, Strub, B, Abebe, M, Abebe, Z, Adhena, BM, Adhikari, TB, Akibu, M, Al-Raddadi, RM, Alvis-Guzman, N, Antonio, CAT, Aremu, O, Asgedom, SW, Asseffa, NA, Avila-Burgos, L, Barac, A, Bärnighausen, TW, Bassat, Q, Bensenor, IM, Bhutta, ZA, Bijani, A, Bililign, N, Cahuana-Hurtado, L, Malta, DC, Chang, J-C, Charlson, FJ, Dharmaratne, SD, Doku, DT, Edessa, D, El-Khatib, Z, Erskine, HE, Ferrari, AJ, Fullman, N, Gupta, R, Hassen, HY, Hay, SI, Ilesanmi, OS, Jacobsen, KH, Kahsay, A, Kasaeian, A, Kassa, TD, Kebede, S, Khader, YS, Khan, EA, Khan, MN, Khang, Y-H, Khubchandani, J, Kinfu, Y, Kochhar, S, Kokubo, Y, Koyanagi, A, Defo, BK, Lal, DK, Kumsa, FA, Larson, HJ, Leung, J, Mamun, AA, Mehata, S, Melku, M, Mendoza, W, Mezgebe, HB, Miller, TR, Moges, NA, Mohammed, S, Mokdad, AH, Monasta, L, Neupane, S, Nguyen, HLT, Ningrum, DNA, Nirayo, YL, Nong, VM, Ogbo, FA, Olagunju, AT, Olusanya, BO, Olusanya, JO, Patton, GC, Pereira, DM, Pourmalek, F, Qorbani, M, Rafay, A, Rai, RK, Ram, U, Ranabhat, CL, Renzaho, AMN, Rezai, MS, Ronfani, L, Roth, GA, Safiri, S, Sartorius, B, Scott, JG, Shackelford, KA, Sliwa, K, Sreeramareddy, C, Sufiyan, MB, Terkawi, AS, Topor-Madry, R, Tran, BX, Ukwaja, KN, Uthman, OA, Vollset, SE, Weldegwergs, KG, Werdecker, A, Whiteford, HA, Wijeratne, T, Yonemoto, N, Yotebieng, M, Zuhlke, LJ, Kyu, HH, Naghavi, M, Vos, T, Murray, CJL, and Collaborators, GBD 2017 Child And Adolescent Health
Subjects: Male, Adolescent, Adolescent Health, Global Health, Global Burden of Disease, Young Adult, Age Distribution, Spatio-Temporal Analysis, Risk Factors, Humans, Online First, Sex Distribution, Child, Original Investigation, Research, Child Health, Infant, Newborn, food and beverages, Infant, Featured, Online Only, Socioeconomic Factors, Child, Preschool, Wounds and Injuries, Female, Quality-Adjusted Life Years, Morbidity
Abstract: Key Points Question How have the levels, trends, and leading causes of child and adolescent mortality and nonfatal health loss changed from 1990 to 2017? Findings This study found that child and adolescent mortality decreased throughout the world from 1990 to 2017, but morbidity has increased as a proportion of total disease burden, because the major causes of nonfatal health loss during childhood and adolescence have not changed dramatically. Meaning As the global health community continues to prioritize child and adolescent health during the Sustainable Development Goal era, careful attention should also be placed on examining and addressing nonfatal illness and disability across the development spectrum., This analysis of the Global Disease Burden data estimates mortality and morbidity in children and adolescents from 1990 to 2017 by age and sex in 195 countries and territories worldwide., Importance Understanding causes and correlates of health loss among children and adolescents can identify areas of success, stagnation, and emerging threats and thereby facilitate effective improvement strategies. Objective To estimate mortality and morbidity in children and adolescents from 1990 to 2017 by age and sex in 195 countries and territories. Design, Setting, and Participants This study examined levels, trends, and spatiotemporal patterns of cause-specific mortality and nonfatal health outcomes using standardized approaches to data processing and statistical analysis. It also describes epidemiologic transitions by evaluating historical associations between disease indicators and the Socio-Demographic Index (SDI), a composite indicator of income, educational attainment, and fertility. Data collected from 1990 to 2017 on children and adolescents from birth through 19 years of age in 195 countries and territories were assessed. Data analysis occurred from January 2018 to August 2018. Exposures Being under the age of 20 years between 1990 and 2017. Main Outcomes and Measures Death and disability. All-cause and cause-specific deaths, disability-adjusted life years, years of life lost, and years of life lived with disability. Results Child and adolescent deaths decreased 51.7% from 13.77 million (95% uncertainty interval [UI], 13.60-13.93 million) in 1990 to 6.64 million (95% UI, 6.44-6.87 million) in 2017, but in 2017, aggregate disability increased 4.7% to a total of 145 million (95% UI, 107-190 million) years lived with disability globally. Progress was uneven, and inequity increased, with low-SDI and low-middle–SDI locations experiencing 82.2% (95% UI, 81.6%-82.9%) of deaths, up from 70.9% (95% UI, 70.4%-71.4%) in 1990. The leading disaggregated causes of disability-adjusted life years in 2017 in the low-SDI quintile were neonatal disorders, lower respiratory infections, diarrhea, malaria, and congenital birth defects, whereas neonatal disorders, congenital birth defects, headache, dermatitis, and anxiety were highest-ranked in the high-SDI quintile. Conclusions and Relevance Mortality reductions over this 27-year period mean that children are more likely than ever to reach their 20th birthdays. The concomitant expansion of nonfatal health loss and epidemiological transition in children and adolescents, especially in low-SDI and middle-SDI countries, has the potential to increase already overburdened health systems, will affect the human capital potential of societies, and may influence the trajectory of socioeconomic development. Continued monitoring of child and adolescent health loss is crucial to sustain the progress of the past 27 years.
Published: 2019

9. Diseases, injuries, and risk factors in child and adolescent health, 1990 to 2017: Findings from the global burden of diseases, injuries, and risk factors 2017 study

Author: GBD 2017 Child and Adolescent Health Collaborators, Reiner RC, Olsen HE, Ikeda CT, Echko MM, Ballestreros KE, Manguerra H, Martopullo I, Millear A, Shields C, Smith A, Kokubo Y, Koyanagi A, Defo BK, Lal DK, Kumsa FA, Larson HJ, Leung J, Mamun AA, Mehata S, Melku M, Nong VM, Mendoza W, Mezgebe HB, Miller TR, Moges NA, Mohammed S, Mokdad AH, Monasta L, Neupane S, Nguyen HLT, Ningrum DNA, Ogbo FA, Nirayo YL, Olagunju AT, Olusanya BO, Olusanya JO, Patton GC, Pereira DM, Pourmalek F, Qorbani M, Rafay A, Sliwa K, Rai RK, Ram U, Ranabhat CL, Renzaho AMN, Rezai MS, Ronfani L, Roth GA, Safiri S, Sartorius B, Scott JG, Sreeramareddy C, Shackelford KA, Sufiyan MB, Terkawi AS, Topor-Madry R, Tran BX, Ukwaja KN, Uthman OA, Vollset SE, Weldegwergs KG, Strub B, Werdecker A, Whiteford HA, Wijeratne T, Yonemoto N, Yotebieng M, Zuhlke LJ, Kyu HH, Naghavi M, Vos T, Murray CJL, Abebe M, Kassebaum NJ, Abebe Z, Adhena BM, Adhikari TB, Akibu M, Al-Raddadi RM, Alvis-Guzman N, Antonio CAT, Aremu O, Asgedom SW, Asseffa NA, Avila-Burgos L, Barac A, Bärnighausen TW, Bassat Q, Bensenor IM, Bhutta ZA, Bijani A, Bililign N, Cahuana-Hurtado L, Malta DC, Chang J-C, Charlson FJ, Dharmaratne SD, Doku DT, Edessa D, El-Khatib Z, Erskine HE, Ferrari AJ, Fullman N, Gupta R, Hassen HY, Hay SI, Ilesanmi OS, Jacobsen KH, Kahsay A, Kasaeian A, Kassa TD, Kebede S, Khader YS, Khan EA, Khan MN, Khang Y-H, Khubchandani J, Kinfu Y, and Kochhar S
Subjects: Male, Adolescent, Infant, Newborn, Adolescent Health, Child Health, Infant, Global Health, Pediatrics, Global Burden of Disease, Young Adult, Age Distribution, Spatio-Temporal Analysis, Socioeconomic Factors, Risk Factors, Child, Preschool, 1114 Paediatrics and Reproductive Medicine, Humans, Wounds and Injuries, Female, Quality-Adjusted Life Years, Morbidity, Sex Distribution, Child
Abstract: Importance Understanding causes and correlates of health loss among children and adolescents can identify areas of success, stagnation, and emerging threats and thereby facilitate effective improvement strategies. Objective To estimate mortality and morbidity in children and adolescents from 1990 to 2017 by age and sex in 195 countries and territories. Design, Setting, and Participants This study examined levels, trends, and spatiotemporal patterns of cause-specific mortality and nonfatal health outcomes using standardized approaches to data processing and statistical analysis. It also describes epidemiologic transitions by evaluating historical associations between disease indicators and the Socio-Demographic Index (SDI), a composite indicator of income, educational attainment, and fertility. Data collected from 1990 to 2017 on children and adolescents from birth through 19 years of age in 195 countries and territories were assessed. Data analysis occurred from January 2018 to August 2018. Exposures Being under the age of 20 years between 1990 and 2017. Main Outcomes and Measures Death and disability. All-cause and cause-specific deaths, disability-adjusted life years, years of life lost, and years of life lived with disability. Results Child and adolescent deaths decreased 51.7% from 13.77 million (95% uncertainty interval [UI], 13.60-13.93 million) in 1990 to 6.64 million (95% UI, 6.44-6.87 million) in 2017, but in 2017, aggregate disability increased 4.7% to a total of 145 million (95% UI, 107-190 million) years lived with disability globally. Progress was uneven, and inequity increased, with low-SDI and low-middle–SDI locations experiencing 82.2% (95% UI, 81.6%-82.9%) of deaths, up from 70.9% (95% UI, 70.4%-71.4%) in 1990. The leading disaggregated causes of disability-adjusted life years in 2017 in the low-SDI quintile were neonatal disorders, lower respiratory infections, diarrhea, malaria, and congenital birth defects, whereas neonatal disorders, congenital birth defects, headache, dermatitis, and anxiety were highest-ranked in the high-SDI quintile. Conclusions and Relevance Mortality reductions over this 27-year period mean that children are more likely than ever to reach their 20th birthdays. The concomitant expansion of nonfatal health loss and epidemiological transition in children and adolescents, especially in low-SDI and middle-SDI countries, has the potential to increase already overburdened health systems, will affect the human capital potential of societies, and may influence the trajectory of socioeconomic development. Continued monitoring of child and adolescent health loss is crucial to sustain the progress of the past 27 years.
Published: 2019

10. Estimates of the global, regional, and national morbidity, mortality, and aetiologies of lower respiratory infections in 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016

Author: Troeger, C, Blacker, BF, Khalil, IA, Rao, PC, Cao, S, Zimsen, SRM, Albertson, S, Stanaway, JD, Deshpande, A, Farag, T, Forouzanfar, MH, Abebe, Z, Adetifa, IMO, Adhikari, TB, Akibu, M, Lami, FH, Al-Eyadhy, A, Alvis-Guzman, N, Amare, AT, Amoako, YA, Antonio, CAT, Aremu, O, Asfaw, ET, Asgedom, SW, Atey, TM, Attia, EF, Avokpaho, EFGA, Ayele, HT, Ayuk, TB, Balakrishnan, K, Barac, A, Bassat, Q, Behzadifar, M, Bhaumik, S, Bhutta, ZA, Bijani, A, Brauer, M, Brown, A, Camargos, PAM, Castaneda-Orjuela, CA, Colombara, D, Conti, S, Dadi, AF, Dandona, L, Dandona, R, Do, HP, Dubljanin, E, Edessa, D, Elkout, H, Endries, AY, Fijabi, DO, Foreman, KJ, Fullman, N, Garcia-Basteiro, AL, Gessner, BD, Gething, PW, Gupta, R, Gupta, T, Hailu, GB, Hassen, HY, Hedayati, MT, Heidari, M, Hibstu, DT, Horita, N, Ilesanmi, OS, Jakovljevic, MB, Jamal, AA, Kahsay, A, Kasaeian, A, Kassa, DH, Khader, YS, Khan, EA, Khan, MN, Khang, Y-H, Kim, YJ, Kissoon, N, Knibbs, LD, Kochhar, S, Koul, PA, Kumar, GA, Lodha, R, Razek, HM, Malta, DC, Mathew, JL, Mengistu, DT, Mezgebe, HB, Mohammad, KA, Mohammed, AM, Momeniha, F, Murthy, S, Nguyen, CT, Nielsen, KR, Ningrum, DNA, Nirayo, YL, Oren, E, Ortiz, JR, Mahesh, PA, Postma, MJ, Qorbani, M, Quansah, R, Rai, RK, Rana, SM, Ranabhat, CL, Ray, SE, Rezai, MS, Ruhago, GM, Safiri, S, Salomon, JA, Sartorius, B, Savic, M, Sawhney, M, She, J, Sheikh, A, Shiferaw, MS, Shigematsu, M, Singh, JA, Somayaji, R, Sufiyan, MB, Taffere, GR, Temsah, M-H, Thompson, MJ, Tobe-Gai, R, Topor-Madry, R, Tran, BX, Tran, TT, Tuem, KB, Ukwaja, KN, Vollset, SE, Walson, JL, Weldegebreal, F, Werdecker, A, West, TE, Yonemoto, N, Zaki, MES, Zhou, L, Zodpey, S, Vos, T, Lim, SS, Naghavi, M, Murray, CJL, Mokdad, AH, Hay, SI, Jr, RRC, and Infecti, GBDLR
Subjects: Adult, Aged, 80 and over, Male, Adolescent, Incidence, Infant, Newborn, Infant, Respiratory Tract Infections/epidemiology, Biostatistics, Middle Aged, Global Health, Survival Analysis, Young Adult, Cost of Illness, Risk Factors, Child, Preschool, Prevalence, Humans, Female, Topography, Medical, Virus Diseases/epidemiology, Child, Epidemiologic Methods, Bacterial Infections/epidemiology, Aged
Abstract: Background Lower respiratory infections are a leading cause of morbidity and mortality around the world. The Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study 2016, provides an up-to-date analysis of the burden of lower respiratory infections in 195 countries. This study assesses cases, deaths, and aetiologies spanning the past 26 years and shows how the burden of lower respiratory infection has changed in people of all ages. Methods We used three separate modelling strategies for lower respiratory infections in GBD 2016: a Bayesian hierarchical ensemble modelling platform (Cause of Death Ensemble model), which uses vital registration, verbal autopsy data, and surveillance system data to predict mortality due to lower respiratory infections; a compartmental meta-regression tool (DisMod-MR), which uses scientific literature, population representative surveys, and healthcare data to predict incidence, prevalence, and mortality; and modelling of counterfactual estimates of the population attributable fraction of lower respiratory infection episodes due to Streptococcus pneumoniae, Haemophilus influenzae type b, influenza, and respiratory syncytial virus. We calculated each modelled estimate for each age, sex, year, and location. We modelled the exposure level in a population for a given risk factor using DisMod-MR and a spatiotemporal Gaussian process regression, and assessed the effectiveness of targeted interventions for each risk factor in children younger than 5 years. We also did a decomposition analysis of the change in LRI deaths from 2000–16 using the risk factors associated with LRI in GBD 2016. Findings In 2016, lower respiratory infections caused 652 572 deaths (95% uncertainty interval [UI] 586 475–720 612) in children younger than 5 years (under-5s), 1 080 958 deaths (943 749–1 170 638) in adults older than 70 years, and 2 377 697 deaths (2 145 584–2 512 809) in people of all ages, worldwide. Streptococcus pneumoniae was the leading cause of lower respiratory infection morbidity and mortality globally, contributing to more deaths than all other aetiologies combined in 2016 (1 189 937 deaths, 95% UI 690 445–1 770 660). Childhood wasting remains the leading risk factor for lower respiratory infection mortality among children younger than 5 years, responsible for 61·4% of lower respiratory infection deaths in 2016 (95% UI 45·7–69·6). Interventions to improve wasting, household air pollution, ambient particulate matter pollution, and expanded antibiotic use could avert one under-5 death due to lower respiratory infection for every 4000 children treated in the countries with the highest lower respiratory infection burden. Interpretation Our findings show substantial progress in the reduction of lower respiratory infection burden, but this progress has not been equal across locations, has been driven by decreases in several primary risk factors, and might require more effort among elderly adults. By highlighting regions and populations with the highest burden, and the risk factors that could have the greatest effect, funders, policy makers, and programme implementers can more effectively reduce lower respiratory infections among the world’s most susceptible populations.
Published: 2019

11. Global, regional, and national burden of traumatic brain injury and spinal cord injury, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016

Author: James, SL, Theadom, A, Ellenbogen, RG, Bannick, MS, Mountjoy-Venning, WC, Lucchesi, LR, Abbasi, N, Abdulkader, R, Abraha, HN, Adsuar, JC, Afarideh, M, Agrawal, S, Ahmadi, A, Ahmed, MB, Aichour, AN, Aichour, I, Aichour, MTE, Akinyemi, RO, Akseer, N, Alahdab, F, Alebel, A, Alghnam, SA, Ali, BA, Alsharif, U, Altirkawi, K, Andrei, CL, Anjomshoa, M, Ansari, H, Ansha, MG, Antonio, CAT, Appiah, SCY, Ariani, F, Asefa, NG, Asgedom, SW, Atique, S, Awasthi, A, Quintanilla, BPA, Ayuk, TB, Azzopardi, PS, Badali, H, Badawi, A, Balalla, S, Banstola, A, Barker-Collo, SL, Barnighausen, TW, Bedi, N, Behzadifar, M, Bekele, BB, Belachew, AB, Belay, YA, Bennett, DA, Bensenor, IM, Berhane, A, Beuran, M, Bhalla, A, Bhaumik, S, Bhutta, ZA, Biadgo, B, Biffino, M, Bijani, A, Bililign, N, Birungi, C, Boufous, S, Brazinova, A, Brown, AW, Car, M, Cardenas, R, Carrero, JJ, Carvalho, F, Castaneda-Orjuela, CA, Catala-Lopez, F, Chaiah, Y, Champs, AP, Chang, J-C, Choi, J-YJ, Christopher, DJ, Cooper, C, Crowe, CS, Dandona, L, Dandona, R, Daryani, A, Davitoiu, DV, Degefa, MG, Demoz, GT, Deribe, K, Djalalinia, S, Huyen, PD, Doku, DT, Drake, TM, Dubey, M, Dubljanin, E, El-Khatib, Z, Eskandarieh, S, Esteghamati, A, Esteghamati, S, Faro, A, Farzadfar, F, Farzaei, MH, Fereshtehnejad, S-M, Fernandes, E, Feyissa, GT, Filip, I, Fischer, F, Fukumoto, T, Ganji, M, Gankpe, FG, Gebre, AK, Gebrehiwot, TT, Gezae, KE, Gopalkrishna, G, Goulart, AC, Haagsma, JA, Haj-Mirzaian, A, Hamadeh, RR, Hamidi, S, Haro, JM, Hassankhani, H, Hassen, HY, Havmoeller, R, Hawley, C, Hay, SI, Hegazy, MI, Hendrie, D, Henok, A, Hibstu, DT, Hoffman, HJ, Hole, MK, Rad, EH, Hosseini, SM, Hostiuc, S, Hu, G, Hussen, MA, Ilesanmi, OS, Irvani, SN, Jakovljevic, M, Jayaraman, S, Jha, RP, Jonas, JB, Jones, KM, Shushtari, ZJ, Jozwiak, JJ, Jurisson, M, Kabir, A, Kahsay, A, Kahssay, M, Kalani, R, Karch, A, Kasaeian, A, Kassa, GM, Kassa, TD, Kassa, ZY, Kengne, AP, Khader, YS, Khafaie, MA, Khalid, N, Khalil, I, Khan, EA, Khan, MS, Khang, Y-H, Khazaie, H, Khoja, AT, Khubchandani, J, Kiadaliri, AA, Kim, D, Kim, Y-E, Kisa, A, Koyanagi, A, Krohn, KJ, Defo, BK, Bicer, BK, Kumar, GA, Kumar, M, Lalloo, R, Lami, FH, Lansingh, VC, Laryea, DO, Latifi, A, Leshargie, CT, Levi, M, Li, S, Liben, ML, Lotufo, PA, Lunevicius, R, Mahotra, NB, Majdan, M, Majeed, A, Malekzadeh, R, Manda, A-L, Mansournia, MA, Massenburg, BB, Mate, KKV, Mehndiratta, MM, Mehta, V, Meles, H, Melese, A, Memiah, PTN, Mendoza, W, Mengistu, G, Meretoja, A, Meretoja, TJ, Mestrovic, T, Miazgowski, T, Miller, TR, Mini, GK, Mirica, A, Mirrakhimov, EM, Moazen, B, Mohammadi, M, Mokdad, AH, Molokhia, M, Monasta, L, Mondello, S, Moosazadeh, M, Moradi, G, Moradi, M, Moradi-Lakeh, M, Moradinazar, M, Morrison, SD, Moschos, MM, Mousavi, SM, Murthy, S, Musa, KI, Mustafa, G, Naghavi, M, Naik, G, Najafi, F, Nangia, V, Nascimento, BR, Negoi, I, Trang, HN, Nichols, E, Ningrum, DNA, Nirayo, YL, Nyasulu, PS, Ofori-Asenso, R, Ogbo, FA, Oh, I-H, Okoro, A, Olagunju, AT, Olagunju, TO, Olivares, PR, Otstavnov, SS, Owolabi, MO, Mahesh, PA, Pakhale, S, Pandey, AR, Pesudovs, K, Pinilla-Monsalve, GD, Polinder, S, Poustchi, H, Prakash, S, Qorbani, M, Radfar, A, Rafay, A, Rafiei, A, Rahimi-Movaghar, A, Rahimi-Movaghar, V, Rahman, M, Rahman, MA, Rai, RK, Rajati, F, Ram, U, Rawaf, DL, Rawaf, S, Reiner, RC, Reis, C, Renzaho, AMN, Resnikoff, S, Rezaei, S, Rezaeian, S, Roever, L, Ronfani, L, Roshandel, G, Roy, N, Ruhago, GM, Saddik, B, Safari, H, Safiri, S, Sahraian, MA, Salamati, P, Saldanha, RDF, Samy, AM, Sanabria, J, Santos, JV, Milicevic, MMMS, Sartorius, B, Satpathy, M, Schneider, IJC, Schwebel, DC, Sepanlou, SG, Shabaninejad, H, Shaikh, MAA, Shams-Beyranvand, M, Sharif, M, Sharif-Alhoseini, M, Islam, SMS, She, J, Sheikh, A, Shen, J, Sheth, KN, Shibuya, K, Shiferaw, MS, Shigematsu, M, Shiri, R, Shiue, I, Shoman, H, Siabani, S, Siddiqi, TJ, Silva, JP, Silveira, DGA, Sinha, DN, Smith, M, Soares Filho, AM, Sobhani, S, Soofi, M, Soriano, JB, Soyiri, IN, Stein, DJ, Stokes, MA, Sufiyan, MB, Sunguya, BF, Sunshine, JE, Sykes, BL, Szoeke, CEI, Tabares-Seisdedos, R, Ao, BJT, Tehrani-Banihashemi, A, Tekle, MG, Temsah, M-H, Temsah, O, Topor-Madry, R, Tortajada-Girbes, M, Bach, XT, Khanh, BT, Car, LT, Ukwaja, KN, Ullah, I, Usman, MS, Uthman, OA, Valdez, PR, Vasankari, TJ, Venketasubramanian, N, Violante, FS, Wagnew, FS, Waheed, Y, Wang, Y-P, Weldegwergs, KG, Werdecker, A, Wijeratne, T, Winkler, AS, Wyper, GMA, Yano, Y, Yaseri, M, Yasin, YJ, Ye, P, Yimer, EM, Yip, P, Yisma, E, Yonemoto, N, Yoon, S-J, Yost, MG, Younis, MZ, Yousefifard, M, Yu, C, Zaidi, Z, Bin Zaman, S, Zamani, M, Zenebe, ZM, Zodpey, S, Feigin, VL, Vos, T, Murray, CJL, James, SL, Theadom, A, Ellenbogen, RG, Bannick, MS, Mountjoy-Venning, WC, Lucchesi, LR, Abbasi, N, Abdulkader, R, Abraha, HN, Adsuar, JC, Afarideh, M, Agrawal, S, Ahmadi, A, Ahmed, MB, Aichour, AN, Aichour, I, Aichour, MTE, Akinyemi, RO, Akseer, N, Alahdab, F, Alebel, A, Alghnam, SA, Ali, BA, Alsharif, U, Altirkawi, K, Andrei, CL, Anjomshoa, M, Ansari, H, Ansha, MG, Antonio, CAT, Appiah, SCY, Ariani, F, Asefa, NG, Asgedom, SW, Atique, S, Awasthi, A, Quintanilla, BPA, Ayuk, TB, Azzopardi, PS, Badali, H, Badawi, A, Balalla, S, Banstola, A, Barker-Collo, SL, Barnighausen, TW, Bedi, N, Behzadifar, M, Bekele, BB, Belachew, AB, Belay, YA, Bennett, DA, Bensenor, IM, Berhane, A, Beuran, M, Bhalla, A, Bhaumik, S, Bhutta, ZA, Biadgo, B, Biffino, M, Bijani, A, Bililign, N, Birungi, C, Boufous, S, Brazinova, A, Brown, AW, Car, M, Cardenas, R, Carrero, JJ, Carvalho, F, Castaneda-Orjuela, CA, Catala-Lopez, F, Chaiah, Y, Champs, AP, Chang, J-C, Choi, J-YJ, Christopher, DJ, Cooper, C, Crowe, CS, Dandona, L, Dandona, R, Daryani, A, Davitoiu, DV, Degefa, MG, Demoz, GT, Deribe, K, Djalalinia, S, Huyen, PD, Doku, DT, Drake, TM, Dubey, M, Dubljanin, E, El-Khatib, Z, Eskandarieh, S, Esteghamati, A, Esteghamati, S, Faro, A, Farzadfar, F, Farzaei, MH, Fereshtehnejad, S-M, Fernandes, E, Feyissa, GT, Filip, I, Fischer, F, Fukumoto, T, Ganji, M, Gankpe, FG, Gebre, AK, Gebrehiwot, TT, Gezae, KE, Gopalkrishna, G, Goulart, AC, Haagsma, JA, Haj-Mirzaian, A, Hamadeh, RR, Hamidi, S, Haro, JM, Hassankhani, H, Hassen, HY, Havmoeller, R, Hawley, C, Hay, SI, Hegazy, MI, Hendrie, D, Henok, A, Hibstu, DT, Hoffman, HJ, Hole, MK, Rad, EH, Hosseini, SM, Hostiuc, S, Hu, G, Hussen, MA, Ilesanmi, OS, Irvani, SN, Jakovljevic, M, Jayaraman, S, Jha, RP, Jonas, JB, Jones, KM, Shushtari, ZJ, Jozwiak, JJ, Jurisson, M, Kabir, A, Kahsay, A, Kahssay, M, Kalani, R, Karch, A, Kasaeian, A, Kassa, GM, Kassa, TD, Kassa, ZY, Kengne, AP, Khader, YS, Khafaie, MA, Khalid, N, Khalil, I, Khan, EA, Khan, MS, Khang, Y-H, Khazaie, H, Khoja, AT, Khubchandani, J, Kiadaliri, AA, Kim, D, Kim, Y-E, Kisa, A, Koyanagi, A, Krohn, KJ, Defo, BK, Bicer, BK, Kumar, GA, Kumar, M, Lalloo, R, Lami, FH, Lansingh, VC, Laryea, DO, Latifi, A, Leshargie, CT, Levi, M, Li, S, Liben, ML, Lotufo, PA, Lunevicius, R, Mahotra, NB, Majdan, M, Majeed, A, Malekzadeh, R, Manda, A-L, Mansournia, MA, Massenburg, BB, Mate, KKV, Mehndiratta, MM, Mehta, V, Meles, H, Melese, A, Memiah, PTN, Mendoza, W, Mengistu, G, Meretoja, A, Meretoja, TJ, Mestrovic, T, Miazgowski, T, Miller, TR, Mini, GK, Mirica, A, Mirrakhimov, EM, Moazen, B, Mohammadi, M, Mokdad, AH, Molokhia, M, Monasta, L, Mondello, S, Moosazadeh, M, Moradi, G, Moradi, M, Moradi-Lakeh, M, Moradinazar, M, Morrison, SD, Moschos, MM, Mousavi, SM, Murthy, S, Musa, KI, Mustafa, G, Naghavi, M, Naik, G, Najafi, F, Nangia, V, Nascimento, BR, Negoi, I, Trang, HN, Nichols, E, Ningrum, DNA, Nirayo, YL, Nyasulu, PS, Ofori-Asenso, R, Ogbo, FA, Oh, I-H, Okoro, A, Olagunju, AT, Olagunju, TO, Olivares, PR, Otstavnov, SS, Owolabi, MO, Mahesh, PA, Pakhale, S, Pandey, AR, Pesudovs, K, Pinilla-Monsalve, GD, Polinder, S, Poustchi, H, Prakash, S, Qorbani, M, Radfar, A, Rafay, A, Rafiei, A, Rahimi-Movaghar, A, Rahimi-Movaghar, V, Rahman, M, Rahman, MA, Rai, RK, Rajati, F, Ram, U, Rawaf, DL, Rawaf, S, Reiner, RC, Reis, C, Renzaho, AMN, Resnikoff, S, Rezaei, S, Rezaeian, S, Roever, L, Ronfani, L, Roshandel, G, Roy, N, Ruhago, GM, Saddik, B, Safari, H, Safiri, S, Sahraian, MA, Salamati, P, Saldanha, RDF, Samy, AM, Sanabria, J, Santos, JV, Milicevic, MMMS, Sartorius, B, Satpathy, M, Schneider, IJC, Schwebel, DC, Sepanlou, SG, Shabaninejad, H, Shaikh, MAA, Shams-Beyranvand, M, Sharif, M, Sharif-Alhoseini, M, Islam, SMS, She, J, Sheikh, A, Shen, J, Sheth, KN, Shibuya, K, Shiferaw, MS, Shigematsu, M, Shiri, R, Shiue, I, Shoman, H, Siabani, S, Siddiqi, TJ, Silva, JP, Silveira, DGA, Sinha, DN, Smith, M, Soares Filho, AM, Sobhani, S, Soofi, M, Soriano, JB, Soyiri, IN, Stein, DJ, Stokes, MA, Sufiyan, MB, Sunguya, BF, Sunshine, JE, Sykes, BL, Szoeke, CEI, Tabares-Seisdedos, R, Ao, BJT, Tehrani-Banihashemi, A, Tekle, MG, Temsah, M-H, Temsah, O, Topor-Madry, R, Tortajada-Girbes, M, Bach, XT, Khanh, BT, Car, LT, Ukwaja, KN, Ullah, I, Usman, MS, Uthman, OA, Valdez, PR, Vasankari, TJ, Venketasubramanian, N, Violante, FS, Wagnew, FS, Waheed, Y, Wang, Y-P, Weldegwergs, KG, Werdecker, A, Wijeratne, T, Winkler, AS, Wyper, GMA, Yano, Y, Yaseri, M, Yasin, YJ, Ye, P, Yimer, EM, Yip, P, Yisma, E, Yonemoto, N, Yoon, S-J, Yost, MG, Younis, MZ, Yousefifard, M, Yu, C, Zaidi, Z, Bin Zaman, S, Zamani, M, Zenebe, ZM, Zodpey, S, Feigin, VL, Vos, T, and Murray, CJL
Abstract: BACKGROUND: Traumatic brain injury (TBI) and spinal cord injury (SCI) are increasingly recognised as global health priorities in view of the preventability of most injuries and the complex and expensive medical care they necessitate. We aimed to measure the incidence, prevalence, and years of life lived with disability (YLDs) for TBI and SCI from all causes of injury in every country, to describe how these measures have changed between 1990 and 2016, and to estimate the proportion of TBI and SCI cases caused by different types of injury. METHODS: We used results from the Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study 2016 to measure the global, regional, and national burden of TBI and SCI by age and sex. We measured the incidence and prevalence of all causes of injury requiring medical care in inpatient and outpatient records, literature studies, and survey data. By use of clinical record data, we estimated the proportion of each cause of injury that required medical care that would result in TBI or SCI being considered as the nature of injury. We used literature studies to establish standardised mortality ratios and applied differential equations to convert incidence to prevalence of long-term disability. Finally, we applied GBD disability weights to calculate YLDs. We used a Bayesian meta-regression tool for epidemiological modelling, used cause-specific mortality rates for non-fatal estimation, and adjusted our results for disability experienced with comorbid conditions. We also analysed results on the basis of the Socio-demographic Index, a compound measure of income per capita, education, and fertility. FINDINGS: In 2016, there were 27·08 million (95% uncertainty interval [UI] 24·30-30·30 million) new cases of TBI and 0·93 million (0·78-1·16 million) new cases of SCI, with age-standardised incidence rates of 369 (331-412) per 100 000 population for TBI and 13 (11-16) per 100 000 for SCI. In 2016, the number of prevalent cases of TBI was 55·50
Published: 2019

12. The global burden of typhoid and paratyphoid fevers: a systematic analysis for the Global Burden of Disease Study 2017

Author: Stanaway, JD, Reiner, RC, Blacker, BF, Goldberg, EM, Khalil, IA, Troeger, CE, Andrews, JR, Bhutta, ZA, Crump, JA, Im, J, Marks, F, Mintz, E, Park, SE, Zaidi, AKM, Abebe, Z, Abejie, AN, Adedeji, IA, Ali, BA, Amare, AT, Atalay, HT, Avokpaho, EFGA, Bacha, U, Barac, A, Bedi, N, Berhane, A, Browne, AJ, Chirinos, JL, Chitheer, A, Dolecek, C, Zaki, MES, Eshrati, B, Foreman, KJ, Gemechu, A, Gupta, R, Hailu, GB, Henok, A, Hibstu, DT, Chi, LH, Ilesanmi, OS, Iyer, VJ, Kahsay, A, Kasaeian, A, Kassa, TD, Khan, EA, Khang, Y-H, El Razek, HMA, Melku, M, Mengistu, DT, Mohammad, KA, Mohammed, S, Mokdad, AH, Nachega, JB, Naheed, A, Cuong, TN, Huong, LTN, Long, HN, Nam, BN, Trang, HN, Nirayo, YL, Pangestu, T, Patton, GC, Qorbani, M, Rai, RK, Rana, SM, Ranabhat, CL, Roba, KT, Roberts, NLS, Rubino, S, Safiri, S, Sartorius, B, Sawhney, M, Shiferaw, MS, Smith, DL, Sykes, BL, Bach, XT, Tung, TT, Ukwaja, KN, Giang, TV, Linh, GV, Weldegebreal, F, Yenit, MK, Murray, CJL, Hay, SI, Stanaway, JD, Reiner, RC, Blacker, BF, Goldberg, EM, Khalil, IA, Troeger, CE, Andrews, JR, Bhutta, ZA, Crump, JA, Im, J, Marks, F, Mintz, E, Park, SE, Zaidi, AKM, Abebe, Z, Abejie, AN, Adedeji, IA, Ali, BA, Amare, AT, Atalay, HT, Avokpaho, EFGA, Bacha, U, Barac, A, Bedi, N, Berhane, A, Browne, AJ, Chirinos, JL, Chitheer, A, Dolecek, C, Zaki, MES, Eshrati, B, Foreman, KJ, Gemechu, A, Gupta, R, Hailu, GB, Henok, A, Hibstu, DT, Chi, LH, Ilesanmi, OS, Iyer, VJ, Kahsay, A, Kasaeian, A, Kassa, TD, Khan, EA, Khang, Y-H, El Razek, HMA, Melku, M, Mengistu, DT, Mohammad, KA, Mohammed, S, Mokdad, AH, Nachega, JB, Naheed, A, Cuong, TN, Huong, LTN, Long, HN, Nam, BN, Trang, HN, Nirayo, YL, Pangestu, T, Patton, GC, Qorbani, M, Rai, RK, Rana, SM, Ranabhat, CL, Roba, KT, Roberts, NLS, Rubino, S, Safiri, S, Sartorius, B, Sawhney, M, Shiferaw, MS, Smith, DL, Sykes, BL, Bach, XT, Tung, TT, Ukwaja, KN, Giang, TV, Linh, GV, Weldegebreal, F, Yenit, MK, Murray, CJL, and Hay, SI
Abstract: BACKGROUND: Efforts to quantify the global burden of enteric fever are valuable for understanding the health lost and the large-scale spatial distribution of the disease. We present the estimates of typhoid and paratyphoid fever burden from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017, and the approach taken to produce them. METHODS: For this systematic analysis we broke down the relative contributions of typhoid and paratyphoid fevers by country, year, and age, and analysed trends in incidence and mortality. We modelled the combined incidence of typhoid and paratyphoid fevers and split these total cases proportionally between typhoid and paratyphoid fevers using aetiological proportion models. We estimated deaths using vital registration data for countries with sufficiently high data completeness and using a natural history approach for other locations. We also estimated disability-adjusted life-years (DALYs) for typhoid and paratyphoid fevers. FINDINGS: Globally, 14·3 million (95% uncertainty interval [UI] 12·5-16·3) cases of typhoid and paratyphoid fevers occurred in 2017, a 44·6% (42·2-47·0) decline from 25·9 million (22·0-29·9) in 1990. Age-standardised incidence rates declined by 54·9% (53·4-56·5), from 439·2 (376·7-507·7) per 100 000 person-years in 1990, to 197·8 (172·0-226·2) per 100 000 person-years in 2017. In 2017, Salmonella enterica serotype Typhi caused 76·3% (71·8-80·5) of cases of enteric fever. We estimated a global case fatality of 0·95% (0·54-1·53) in 2017, with higher case fatality estimates among children and older adults, and among those living in lower-income countries. We therefore estimated 135·9 thousand (76·9-218·9) deaths from typhoid and paratyphoid fever globally in 2017, a 41·0% (33·6-48·3) decline from 230·5 thousand (131·2-372·6) in 1990. Overall, typhoid and paratyphoid fevers were responsible for 9·8 million (5·6-15·8) DALYs in 2017, down 43·0% (35·5-50·6) from 17·2 million (9·9-27·8) DALYs in 1990. I
Published: 2019

13. Global, regional, and national burden of meningitis, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016

Author: Zunt, JR, Kassebaum, NJ, Blake, N, Glennie, L, Wright, C, Nichols, E, Abd-Allah, F, Abdela, J, Abdelalim, A, Adamu, AA, Adib, MG, Ahmadi, A, Ahmed, MB, Aichour, AN, Aichour, I, Aichour, MTE, Akseer, N, Al-Raddadi, RM, Alahdab, F, Alene, KA, Aljunid, SM, AlMazora, MA, Khalid, Alvis-Guzman, N, Animut, MD, Anjomshoa, M, Ansha, MG, Asghar, RJ, Avokpaho, EFGA, Awasthi, A, Badali, H, Barac, A, Baernighausen, TW, Bassat, Q, Bedi, N, Belachew, AB, Bhattacharyya, K, Bhutta, ZA, Bijani, A, Butt, ZA, Carvalho, F, Castaneda-Orjuela, CA, Chitheer, A, Choi, J-YJ, Christopher, DJ, Dang, AK, Daryani, A, Demoz, GT, Djalalinia, S, Huyen, PD, Dubey, M, Dubljanin, E, Duken, EE, Zaki, MES, Elyazar, IR, Fakhim, H, Fernandes, E, Fischer, F, Fukumoto, T, Ganji, M, Gebre, AK, Gebremeskel, A, Gessner, BD, Gopalani, SV, Guo, Y, Gupta, R, Hailu, GB, Haj-Mirzaian, A, Hamidi, S, Hay, S, Henok, A, Irvani, SSN, Jha, RP, Jurisson, M, Kahsay, A, Karami, M, Karch, A, Kasaeian, A, Kassa, TD, Kefale, AT, Khader, YS, Khalil, IA, Khan, EA, Khang, Y-H, Khubchandani, J, Kimokoti, RW, Kisa, A, Lami, FH, Levi, M, Li, S, Loy, CT, Majdan, M, Majeed, A, Mantovani, LG, Martins-Melo, FR, McAlinden, C, Mehta, V, Melese, A, Memish, ZA, Mengistu, G, Mestrovic, T, Mezgebe, HB, Miazgowski, B, Milosevic, B, Mokdad, AH, Monasta, L, Moradi, G, Moraga, P, Mousavi, SM, Mueller, UO, Murthy, S, Mustafa, G, Naheed, A, Naik, G, Newton, CRJ, Nirayo, YL, Nixon, MR, Ofori-Asenso, R, Ogbo, FA, Olagunju, TO, Olusanya, BO, Ortiz, JR, Owolabi, MO, Patel, S, Pinilla-Monsalve, GD, Postma, MJ, Qorbani, M, Rafiei, A, Rahimi-Movaghar, V, Reiner, RC, Renzaho, AMN, Rezai, MS, Roba, KT, Ronfani, L, Roshandel, G, Rostami, A, Safari, S, Safiri, S, Sagar, R, Samy, AM, Milicevic, MMS, Sartorius, B, Sarvi, S, Sawhney, M, Saxena, S, Shafieesabet, A, Shaikh, MA, Sharif, M, Shigematsu, M, Si, S, Skiadaresi, E, Smith, M, Somayaji, R, Sufiyan, MB, Tawye, NY, Temsah, M-H, Tortajada-Girbes, M, Khanh, BT, Ukwaja, KN, Ullah, I, Vujcic, IS, Wagnew, F, Waheed, Y, Weldegwergs, KG, Winkler, AS, Wiyeh, AB, Wiysonge, CS, Wyper, GMA, Yimer, EM, Yonemoto, N, Zaidi, Z, Zenebe, ZM, Feigin, VL, Vos, T, and Murray, CJL
Subjects: BACTERIAL-MENINGITIS, RISK, AFRICA, Science & Technology, Neurology & Neurosurgery, IMPACT, Clinical Neurology, UNITED-STATES, CHILDREN, 1103 Clinical Sciences, GBD 2016 Meningitis Collaborators, PNEUMOCOCCAL CONJUGATE VACCINE, HEALTH-CARE, EPIDEMIOLOGY, Neurosciences & Neurology, MENINGOCOCCAL DISEASE, 1109 Neurosciences, Life Sciences & Biomedicine
Abstract: Background Acute meningitis has a high case-fatality rate and survivors can have severe lifelong disability. We aimed to provide a comprehensive assessment of the levels and trends of global meningitis burden that could help to guide introduction, continuation, and ongoing development of vaccines and treatment programmes. Methods The Global Burden of Diseases, Injuries, and Risk Factors (GBD) 2016 study estimated meningitis burden due to one of four types of cause: pneumococcal, meningococcal, Haemophilus influenzae type b, and a residual category of other causes. Cause-specific mortality estimates were generated via cause of death ensemble modelling of vital registration and verbal autopsy data that were subject to standardised data processing algorithms. Deaths were multiplied by the GBD standard life expectancy at age of death to estimate years of life lost, the mortality component of disability-adjusted life-years (DALYs). A systematic analysis of relevant publications and hospital and claims data was used to estimate meningitis incidence via a Bayesian meta-regression tool. Meningitis deaths and cases were split between causes with meta-regressions of aetiological proportions of mortality and incidence, respectively. Probabilities of long-term impairment by cause of meningitis were applied to survivors and used to estimate years of life lived with disability (YLDs). We assessed the relationship between burden metrics and Socio-demographic Index (SDI), a composite measure of development based on fertility, income, and education. Findings Global meningitis deaths decreased by 21·0% from 1990 to 2016, from 403 012 (95% uncertainty interval [UI] 319 426–458 514) to 318 400 (265 218–408 705). Incident cases globally increased from 2·50 million (95% UI 2·19–2·91) in 1990 to 2·82 million (2·46–3·31) in 2016. Meningitis mortality and incidence were closely related to SDI. The highest mortality rates and incidence rates were found in the peri-Sahelian countries that comprise the African meningitis belt, with six of the ten countries with the largest number of cases and deaths being located within this region. Haemophilus influenzae type b was the most common cause of incident meningitis in 1990, at 780 070 cases (95% UI 613 585–978 219) globally, but decreased the most (–49·1%) to become the least common cause in 2016, with 397 297 cases (291 076–533 662). Meningococcus was the leading cause of meningitis mortality in 1990 (192 833 deaths [95% UI 153 358–221 503] globally), whereas other meningitis was the leading cause for both deaths (136 423 [112 682–178 022]) and incident cases (1·25 million [1·06–1·49]) in 2016. Pneumococcus caused the largest number of YLDs (634 458 [444 787–839 749]) in 2016, owing to its more severe long-term effects on survivors. Globally in 2016, 1·48 million (1·04—1·96) YLDs were due to meningitis compared with 21·87 million (18·20—28·28) DALYs, indicating that the contribution of mortality to meningitis burden is far greater than the contribution of disabling outcomes. Interpretation Meningitis burden remains high and progress lags substantially behind that of other vaccine-preventable diseases. Particular attention should be given to developing vaccines with broader coverage against the causes of meningitis, making these vaccines affordable in the most affected countries, improving vaccine uptake, improving access to low-cost diagnostics and therapeutics, and improving support for disabled survivors. Substantial uncertainty remains around pathogenic causes and risk factors for meningitis. Ongoing, active cause-specific surveillance of meningitis is crucial to continue and to improve monitoring of meningitis burdens and trends throughout the world.
Published: 2018

14. Estimates of the global, regional, and national morbidity, mortality, and aetiologies of diarrhoea in 195 countries: a systematic analysis for the Global Burden of Disease Study 2016

Author: Troeger, C, Blacker, BF, Khalil, IA, Rao, PC, Cao, S, Zimsen, SRM, Albertson, SB, Stanaway, JD, Deshpande, A, Abebe, Z, Alvis-Guzman, N, Amare, AT, Asgedom, SW, Anteneh, ZA, Antonio, CAT, Aremu, O, Asfaw, ET, Atey, TM, Atique, S, Avokpaho, EFGA, Awasthi, A, Ayele, HT, Barac, A, Barreto, ML, Bassat, Q, Belay, SA, Bensenor, IM, Bhutta, ZA, Bijani, A, Bizuneh, H, Castañeda-Orjuela, CA, Dadi, AF, Dandona, L, Dandona, R, Do, HP, Dubey, M, Dubljanin, E, Edessa, D, Endries, AY, Eshrati, B, Farag, T, Feyissa, GT, Foreman, KJ, Forouzanfar, MH, Fullman, N, Gething, PW, Gishu, MD, Godwin, WW, Gugnani, HC, Gupta, R, Hailu, GB, Hassen, HY, Hibstu, DT, Ilesanmi, OS, Jonas, JB, Kahsay, A, Kang, G, Kasaeian, A, Khader, YS, Khan, EA, Khan, MA, Khang, Y-H, Kissoon, N, Kochhar, S, Kotloff, KL, Koyanagi, A, Kumar, GA, Magdy Abd El Razek, H, Malekzadeh, R, Malta, DC, Mehata, S, Mendoza, W, Mengistu, DT, Menota, BG, Mezgebe, HB, Mlashu, FW, Murthy, S, Naik, GA, Nguyen, CT, Nguyen, TH, Ningrum, DNA, Ogbo, FA, Olagunju, AT, Paudel, D, Platts-Mills, JA, Qorbani, M, Rafay, A, Rai, RK, Rana, SM, Ranabhat, CL, Rasella, D, Ray, SE, Reis, C, Renzaho, AMN, Rezai, MS, Ruhago, GM, Safiri, S, Salomon, JA, Sanabria, JR, Sartorius, B, Sawhney, M, Sepanlou, SG, Shigematsu, M, Sisay, M, Somayaji, R, Sreeramareddy, CT, Sykes, BL, Taffere, GR, Topor-Madry, R, Tran, BX, Tuem, KB, Ukwaja, KN, Vollset, SE, Walson, JL, Weaver, MR, Weldegwergs, KG, Werdecker, A, Workicho, A, Yenesew, M, Yirsaw, BD, Yonemoto, N, El Sayed Zaki, M, Vos, T, Lim, SS, Naghavi, M, Murray, CJL, Mokdad, AH, Hay, SI, Reiner, RC, and Hay, S
Abstract: Background The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 provides an up-to-date analysis of the burden of diarrhoea in 195 countries. This study assesses cases, deaths, and aetiologies in 1990–2016 and assesses how the burden of diarrhoea has changed in people of all ages Methods We modelled diarrhoea mortality with a Bayesian hierarchical modelling platform that evaluates a wide range of covariates and model types on the basis of vital registration and verbal autopsy data. We modelled diarrhoea incidence with a compartmental meta-regression tool that enforces an association between incidence and prevalence, and relies on scientific literature, population representative surveys, and health-care data. Diarrhoea deaths and episodes were attributed to 13 pathogens by use of a counterfactual population attributable fraction approach. Diarrhoea risk factors are also based on counterfactual estimates of risk exposure and the association between the risk and diarrhoea. Each modelled estimate accounted for uncertainty. Findings In 2016, diarrhoea was the eighth leading cause of death among all ages (1 655 944 deaths, 95% uncertainty interval [UI] 1 244 073–2 366 552) and the fifth leading cause of death among children younger than 5 years (446 000 deaths, 390 894–504 613). Rotavirus was the leading aetiology for diarrhoea mortality among children younger than 5 years (128 515 deaths, 105 138–155 133) and among all ages (228 047 deaths, 183 526–292 737). Childhood wasting (low weight-for-height score), unsafe water, and unsafe sanitation were the leading risk factors for diarrhoea, responsible for 80·4% (95% UI 68·2–85·0), 72·1% (34·0–91·4), and 56·4% (49·3–62·7) of diarrhoea deaths in children younger than 5 years, respectively. Prevention of wasting in 1762 children (95% UI 1521–2170) could avert one death from diarrhoea. Interpretation Substantial progress has been made globally in reducing the burden of diarrhoeal diseases, driven by decreases in several primary risk factors. However, this reduction has not been equal across locations, and burden among adults older than 70 years requires attention.
Published: 2018

15. Global Mortality From Firearms, 1990-2016

Author: Global Burden of Disease 2016 Injury Collaborators, Naghavi M, Marczak LB, Kutz M, Shackelford KA, Arora M, Miller-Petrie M, Aichour MTE, Akseer N, Al-Raddadi RM, Alam K, Alghnam SA, Antonio CAT, Aremu O, Arora A, Asadi-Lari M, Assadi R, Atey TM, Avila-Burgos L, Awasthi A, Ayala Quintanilla BP, Barker-Collo SL, Bärnighausen TW, Bazargan-Hejazi S, Behzadifar M, Bennett JR, Bhalla A, Bhutta ZA, Bilal AI, Borges G, Borschmann R, Brazinova A, Campuzano Rincon JC, Carvalho F, Castañeda-Orjuela CA, Dandona L, Dandona R, Dargan PI, De Leo D, Dharmaratne SD, Ding EL, Phuc Do H, Doku DT, Doyle KE, Driscoll TR, Edessa D, El-Khatib Z, Endries AY, Esteghamati A, Faro A, Farzadfar F, Feigin VL, Fischer F, Foreman KJ, Franklin RC, Fullman N, Futran ND, Gebrehiwot TT, Gutiérrez RA, Hafezi-Nejad N, Haghparast Bidgoli H, Hailu GB, Haro JM, Hassen HY, Hawley C, Hendrie D, Híjar M, Hu G, Ilesanmi OS, Jakovljevic M, James SL, Jayaraman S, Jonas JB, Kahsay A, Kasaeian A, Keiyoro PN, Khader Y, Khalil IA, Khang YH, Khubchandani J, Ahmad Kiadaliri A, Kieling C, Kim YJ, Kosen S, Krohn KJ, Kumar GA, Lami FH, Lansingh VC, Larson HJ, Linn S, Lunevicius R, Magdy Abd El Razek H, Magdy Abd El Razek M, Malekzadeh R, Carvalho Malta D, Mason-Jones AJ, Matzopoulos R, Memiah PTN, Mendoza W, Meretoja TJ, Mezgebe HB, Miller TR, Mohammed S, Moradi-Lakeh M, Mori R, Nand D, Tat Nguyen C, Le Nguyen Q, Ningrum DNA, Akpojene Ogbo F, Olagunju AT, Patton GC, Phillips MR, Polinder S, Pourmalek F, Qorbani M, Rahimi-Movaghar A, Rahimi-Movaghar V, Rahman M, Rai RK, Ranabhat CL, Rawaf DL, Rawaf S, Rowhani-Rahbar A, Safdarian M, Safiri S, Sagar R, Salama JS, Sanabria J, Santric Milicevic MM, Sarmiento-Suárez R, Sartorius B, Satpathy M, Schwebel DC, Seedat S, Sepanlou SG, Shaikh MA, Sharew NT, Shiue I, Singh JA, Sisay M, Skirbekk V, Soares Filho AM, Stein DJ, Stokes MA, Sufiyan MB, Swaroop M, Sykes BL, Tabarés-Seisdedos R, Tadese F, Tran BX, Thanh Tran T, Ukwaja KN, Vasankari TJ, Vlassov V, Werdecker A, Ye P, Yip P, Yonemoto N, Younis MZ, Zaidi Z, El Sayed Zaki M, Hay SI, Lim SS, Lopez AD, Mokdad AH, Vos T, and Murray CJL
Abstract: IMPORTANCE: Understanding global variation in firearm mortality rates could guide prevention policies and interventions. OBJECTIVE: To estimate mortality due to firearm injury deaths from 1990 to 2016 in 195 countries and territories. DESIGN, SETTING, AND PARTICIPANTS: This study used deidentified aggregated data including 13?812 location-years of vital registration data to generate estimates of levels and rates of death by age-sex-year-location. The proportion of suicides in which a firearm was the lethal means was combined with an estimate of per capita gun ownership in a revised proxy measure used to evaluate the relationship between availability or access to firearms and firearm injury deaths. EXPOSURES: Firearm ownership and access. MAIN OUTCOMES AND MEASURES: Cause-specific deaths by age, sex, location, and year. RESULTS: Worldwide, it was estimated that 251?000 (95% uncertainty interval [UI], 195?000-276?000) people died from firearm injuries in 2016, with 6 countries (Brazil, United States, Mexico, Colombia, Venezuela, and Guatemala) accounting for 50.5% (95% UI, 42.2%-54.8%) of those deaths. In 1990, there were an estimated 209?000 (95% UI, 172?000 to 235?000) deaths from firearm injuries. Globally, the majority of firearm injury deaths in 2016 were homicides (64.0% [95% UI, 54.2%-68.0%]; absolute value, 161?000 deaths [95% UI, 107?000-182?000]); additionally, 27% were firearm suicide deaths (67?500 [95% UI, 55?400-84?100]) and 9% were unintentional firearm deaths (23?000 [95% UI, 18?200-24?800]). From 1990 to 2016, there was no significant decrease in the estimated global age-standardized firearm homicide rate (-0.2% [95% UI, -0.8% to 0.2%]). Firearm suicide rates decreased globally at an annualized rate of 1.6% (95% UI, 1.1-2.0), but in 124 of 195 countries and territories included in this study, these levels were either constant or significant increases were estimated. There was an annualized decrease of 0.9% (95% UI, 0.5%-1.3%) in the global rate of age-standardized firearm deaths from 1990 to 2016. Aggregate firearm injury deaths in 2016 were highest among persons aged 20 to 24 years (for men, an estimated 34?700 deaths [95% UI, 24?900-39?700] and for women, an estimated 3580 deaths [95% UI, 2810-4210]). Estimates of the number of firearms by country were associated with higher rates of firearm suicide (P < .001; R2 = 0.21) and homicide (P < .001; R2 = 0.35). CONCLUSIONS AND RELEVANCE: This study estimated between 195?000 and 276?000 firearm injury deaths globally in 2016, the majority of which were firearm homicides. Despite an overall decrease in rates of firearm injury death since 1990, there was variation among countries and across demographic subgroups.
Published: 2018

16. The burden of cardiovascular diseases among us states, 1990-2016

Author: Roth, GA, Johnson, CO, Abate, KH, Abd-Allah, F, Ahmed, M, Alam, K, Alam, T, Alvis-Guzman, N, Ansari, H, Ärnlöv, J, Atey, TM, Awasthi, A, Awoke, T, Barac, A, Bärnighausen, T, Bedi, N, Bennett, D, Bensenor, I, Biadgilign, S, Castañeda-Orjuela, C, Catalá-López, F, Davletov, K, Dharmaratne, S, Ding, EL, Dubey, M, Faraon, EJA, Farid, T, Farvid, MS, Feigin, V, Fernandes, J, Frostad, J, Gebru, A, Geleijnse, JM, Gona, PN, Griswold, M, Hailu, GB, Hankey, GJ, Hassen, HY, Havmoeller, R, Hay, S, Heckbert, SR, Irvine, CMS, James, SL, Jara, D, Kasaeian, A, Khan, AR, Khera, S, Khoja, AT, Khubchandani, J, Kim, D, Kolte, D, Lal, D, Larsson, A, Linn, S, Lotufo, PA, Razek, H, Mazidi, M, Meier, T, Mendoza, W, Mensah, GA, Meretoja, A, Mezgebe, HB, Mirrakhimov, E, Mohammed, S, Moran, AE, Nguyen, G, Nguyen, M, Ong, KL, Owolabi, M, Pletcher, M, Pourmalek, F, Purcell, CA, Qorbani, M, Rahman, M, Rai, RK, Ram, U, Reitsma, MB, Renzaho, AMN, Rios-Blancas, MJ, Safiri, S, Salomon, JA, Sartorius, B, Sepanlou, SG, Shaikh, MA, Silva, D, Stranges, S, Tabarés-Seisdedos, R, Atnafu, N, Thakur, JS, Topor-Madry, R, Truelsen, T, Tuzcu, EM, Tyrovolas, S, Ukwaja, KN, Vasankari, T, Vlassov, V, Vollset, SE, Wakayo, T, Weintraub, R, Wolfe, C, Workicho, A, Xu, G, Yadgir, S, Yano, Y, Yip, P, Yonemoto, N, Younis, M, Yu, C, Zaidi, Z, Zaki, MES, Zipkin, B, Afshin, A, Gakidou, E, Lim, SS, Mokdad, AH, Naghavi, M, Vos, T, and Murray, CJL
Subjects: Kardiologi, Nutrition and Disease, Voeding en Ziekte, Life Science, Cardiac and Cardiovascular Systems, VLAG
Abstract: Importance Cardiovascular disease (CVD) is the leading cause of death in the United States, but regional variation within the United States is large. Comparable and consistent state-level measures of total CVD burden and risk factors have not been produced previously. Objective To quantify and describe levels and trends of lost health due to CVD within the United States from 1990 to 2016 as well as risk factors driving these changes. Design, Setting, and Participants Using the Global Burden of Disease methodology, cardiovascular disease mortality, nonfatal health outcomes, and associated risk factors were analyzed by age group, sex, and year from 1990 to 2016 for all residents in the United States using standardized approaches for data processing and statistical modeling. Burden of disease was estimated for 10 groupings of CVD, and comparative risk analysis was performed. Data were analyzed from August 2016 to July 2017. Exposures Residing in the United States. Main Outcomes and Measures Cardiovascular disease disability-adjusted life-years (DALYs). Results Between 1990 and 2016, age-standardized CVD DALYs for all states decreased. Several states had large rises in their relative rank ordering for total CVD DALYs among states, including Arkansas, Oklahoma, Alabama, Kentucky, Missouri, Indiana, Kansas, Alaska, and Iowa. The rate of decline varied widely across states, and CVD burden increased for a small number of states in the most recent years. Cardiovascular disease DALYs remained twice as large among men compared with women. Ischemic heart disease was the leading cause of CVD DALYs in all states, but the second most common varied by state. Trends were driven by 12 groups of risk factors, with the largest attributable CVD burden due to dietary risk exposures followed by high systolic blood pressure, high body mass index, high total cholesterol level, high fasting plasma glucose level, tobacco smoking, and low levels of physical activity. Increases in risk-deleted CVD DALY rates between 2006 and 2016 in 16 states suggest additional unmeasured risks beyond these traditional factors. Conclusions and Relevance Large disparities in total burden of CVD persist between US states despite marked improvements in CVD burden. Differences in CVD burden are largely attributable to modifiable risk exposures.
Published: 2018

17. Global mortality from firearms, 1990-2016

Author: Naghavi, M, Marczak, LB, Kutz, M, Shackelford, KA, Arora, M, Miller-Petrie, M, Aichour, MTE, Akseer, N, Al-Raddadi, RM, Alam, K, Alghnam, SA, Antonio, CAT, Aremu, O, Arora, A, Asadi-Lari, M, Assadi, R, Atey, TM, Avila-Burgos, L, Awasthi, A, Ayala Quintanilla, BP, Barker-Collo, SL, Bärnighausen, TW, Bazargan-Hejazi, S, Behzadifar, M, Bennett, JR, Bhalla, A, Bhutta, ZA, Bilal, AI, Borges, G, Borschmann, R, Brazinova, A, Campuzano Rincon, JC, Carvalho, F, Castañeda-Orjuela, CA, Dandona, L, Dandona, R, Dargan, PI, De Leo, D, Dharmaratne, SD, Ding, EL, Phuc Do, H, Doku, DT, Doyle, KE, Driscoll, TR, Edessa, D, El-Khatib, Z, Endries, AY, Esteghamati, A, Faro, A, Farzadfar, F, Feigin, VL, Fischer, F, Foreman, KJ, Franklin, RC, Fullman, N, Futran, ND, Gebrehiwot, TT, Gutiérrez, RA, Hafezi-Nejad, N, Haghparast Bidgoli, H, Hailu, GB, Haro, JM, Hassen, HY, Hawley, C, Hendrie, D, Híjar, M, Hu, G, Ilesanmi, OS, Jakovljevic, M, James, SL, Jayaraman, S, Jonas, JB, Kahsay, A, Kasaeian, A, Keiyoro, PN, Khader, Y, Khalil, IA, Khang, Y-H, Khubchandani, J, Ahmad Kiadaliri, A, Kieling, C, Kim, YJ, Kosen, S, Krohn, KJ, Kumar, GA, Lami, FH, Lansingh, VC, Larson, HJ, Linn, S, Lunevicius, R, Magdy Abd El Razek, H, Magdy Abd El Razek, M, Malekzadeh, R, Carvalho Malta, D, Mason-Jones, AJ, Matzopoulos, R, Memiah, PTN, Mendoza, W, Meretoja, TJ, Mezgebe, HB, Miller, TR, Mohammed, S, Moradi-Lakeh, M, Mori, R, Nand, D, Tat Nguyen, C, Le Nguyen, Q, Ningrum, DNA, Akpojene Ogbo, F, Olagunju, AT, Patton, GC, Phillips, MR, Polinder, S, Pourmalek, F, Qorbani, M, Rahimi-Movaghar, A, Rahimi-Movaghar, V, Rahman, M, Rai, RK, Ranabhat, CL, Rawaf, DL, Rawaf, S, Rowhani-Rahbar, A, Safdarian, M, Safiri, S, Sagar, R, Salama, JS, Sanabria, J, Santric Milicevic, MM, Sarmiento-Suárez, R, Sartorius, B, Satpathy, M, Schwebel, DC, Seedat, S, Sepanlou, SG, Shaikh, MA, Sharew, NT, Shiue, I, Singh, JA, Sisay, M, Skirbekk, V, Soares Filho, AM, Stein, DJ, Stokes, Mark Andrew, Sufiyan, MB, Swaroop, M, Sykes, BL, Tabarés-Seisdedos, R, Tadese, F, Tran, BX, Thanh Tran, T, Ukwaja, KN, Vasankari, TJ, Vlassov, V, Werdecker, A, Ye, P, Yip, P, Yonemoto, N, Younis, MZ, Zaidi, Z, El Sayed Zaki, M, Hay, SI, Lim, SS, Lopez, AD, Mokdad, AH, Vos, T, Murray, CJL, Naghavi, M, Marczak, LB, Kutz, M, Shackelford, KA, Arora, M, Miller-Petrie, M, Aichour, MTE, Akseer, N, Al-Raddadi, RM, Alam, K, Alghnam, SA, Antonio, CAT, Aremu, O, Arora, A, Asadi-Lari, M, Assadi, R, Atey, TM, Avila-Burgos, L, Awasthi, A, Ayala Quintanilla, BP, Barker-Collo, SL, Bärnighausen, TW, Bazargan-Hejazi, S, Behzadifar, M, Bennett, JR, Bhalla, A, Bhutta, ZA, Bilal, AI, Borges, G, Borschmann, R, Brazinova, A, Campuzano Rincon, JC, Carvalho, F, Castañeda-Orjuela, CA, Dandona, L, Dandona, R, Dargan, PI, De Leo, D, Dharmaratne, SD, Ding, EL, Phuc Do, H, Doku, DT, Doyle, KE, Driscoll, TR, Edessa, D, El-Khatib, Z, Endries, AY, Esteghamati, A, Faro, A, Farzadfar, F, Feigin, VL, Fischer, F, Foreman, KJ, Franklin, RC, Fullman, N, Futran, ND, Gebrehiwot, TT, Gutiérrez, RA, Hafezi-Nejad, N, Haghparast Bidgoli, H, Hailu, GB, Haro, JM, Hassen, HY, Hawley, C, Hendrie, D, Híjar, M, Hu, G, Ilesanmi, OS, Jakovljevic, M, James, SL, Jayaraman, S, Jonas, JB, Kahsay, A, Kasaeian, A, Keiyoro, PN, Khader, Y, Khalil, IA, Khang, Y-H, Khubchandani, J, Ahmad Kiadaliri, A, Kieling, C, Kim, YJ, Kosen, S, Krohn, KJ, Kumar, GA, Lami, FH, Lansingh, VC, Larson, HJ, Linn, S, Lunevicius, R, Magdy Abd El Razek, H, Magdy Abd El Razek, M, Malekzadeh, R, Carvalho Malta, D, Mason-Jones, AJ, Matzopoulos, R, Memiah, PTN, Mendoza, W, Meretoja, TJ, Mezgebe, HB, Miller, TR, Mohammed, S, Moradi-Lakeh, M, Mori, R, Nand, D, Tat Nguyen, C, Le Nguyen, Q, Ningrum, DNA, Akpojene Ogbo, F, Olagunju, AT, Patton, GC, Phillips, MR, Polinder, S, Pourmalek, F, Qorbani, M, Rahimi-Movaghar, A, Rahimi-Movaghar, V, Rahman, M, Rai, RK, Ranabhat, CL, Rawaf, DL, Rawaf, S, Rowhani-Rahbar, A, Safdarian, M, Safiri, S, Sagar, R, Salama, JS, Sanabria, J, Santric Milicevic, MM, Sarmiento-Suárez, R, Sartorius, B, Satpathy, M, Schwebel, DC, Seedat, S, Sepanlou, SG, Shaikh, MA, Sharew, NT, Shiue, I, Singh, JA, Sisay, M, Skirbekk, V, Soares Filho, AM, Stein, DJ, Stokes, Mark Andrew, Sufiyan, MB, Swaroop, M, Sykes, BL, Tabarés-Seisdedos, R, Tadese, F, Tran, BX, Thanh Tran, T, Ukwaja, KN, Vasankari, TJ, Vlassov, V, Werdecker, A, Ye, P, Yip, P, Yonemoto, N, Younis, MZ, Zaidi, Z, El Sayed Zaki, M, Hay, SI, Lim, SS, Lopez, AD, Mokdad, AH, Vos, T, and Murray, CJL
Published: 2018

18. Intentional injuries in the Eastern Mediterranean Region, 1990-2015: findings from the Global Burden of Disease 2015 study

Author: Mokdad, AH, Moradi-Lakeh, M, Charara, R, El Bcheraoui, C, Khalil, I, Afshin, A, Kassebaum, NJ, Collison, M, Chew, A, Krohn, KJ, Daoud, F, Colombara, D, Graetz, N, Kutz, M, Wang, H, Abd-Allah, F, Abu-Raddad, LJ, Kiadaliri, AA, Ahmed, MB, Alam, K, Alghnam, S, Alizadeh-Navaei, R, Al-Raddadi, R, Altirkawi, KA, Anber, N, Anwari, P, Avila-Burgos, L, Awasthi, A, Barac, A, Barker-Collo, SL, Bedi, N, Bhutta, ZA, Borschmann, R, Boufous, S, Butt, ZA, Castaneda-Orjuela, CA, Dalal, K, Danawi, H, De Leo, D, Dharmaratne, SD, Djalalinia, S, Doyle, KE, Esteghamati, A, Faro, A, Farvid, MS, Fereshtehnejad, S-M, Fischer, F, Gebrehiwot, TT, Gutierrez, RA, Hafezi-Nejad, N, Hamadeh, RR, Hamidi, S, Haro, JM, Hendrie, D, Hu, G, Jonas, JB, Kasaeian, A, Keiyoro, PN, Khader, YS, Khan, EA, Khubchandani, J, Kopec, JA, Larson, HJ, Latif, AA, Leshargie, CT, Lunevicius, R, Abd El Razek, MM, Majeed, A, Malekzadeh, R, Memish, ZA, Meretoja, TJ, Miller, TR, Mohammed, S, Obermeyer, CM, Ogbo, FA, Phillips, MR, Pourmalek, F, Qorbani, M, Radfar, A, Rafay, A, Rahimi-Movaghar, A, Rahimi-Movaghar, V, Rai, RK, Rawaf, DL, Rawaf, S, Rezaei, S, Rezai, MS, Roshandel, G, Safdarian, M, Safiri, S, Salamati, P, Samy, AM, Sartorius, B, Seedat, S, Sepanlou, SG, Shaikh, MA, Sobaih, BHA, Tabb, KM, Tehrani-Banihashemi, A, Temsah, M-H, Terkawi, AS, RomanTopor-Madry, Ukwaja, KN, Uthman, OA, Yaseri, M, NaohiroYonemoto, Younis, MZ, Jumaan, AO, Vos, T, Hay, SI, Naghavi, M, Murray, CJL, Mokdad, AH, Moradi-Lakeh, M, Charara, R, El Bcheraoui, C, Khalil, I, Afshin, A, Kassebaum, NJ, Collison, M, Chew, A, Krohn, KJ, Daoud, F, Colombara, D, Graetz, N, Kutz, M, Wang, H, Abd-Allah, F, Abu-Raddad, LJ, Kiadaliri, AA, Ahmed, MB, Alam, K, Alghnam, S, Alizadeh-Navaei, R, Al-Raddadi, R, Altirkawi, KA, Anber, N, Anwari, P, Avila-Burgos, L, Awasthi, A, Barac, A, Barker-Collo, SL, Bedi, N, Bhutta, ZA, Borschmann, R, Boufous, S, Butt, ZA, Castaneda-Orjuela, CA, Dalal, K, Danawi, H, De Leo, D, Dharmaratne, SD, Djalalinia, S, Doyle, KE, Esteghamati, A, Faro, A, Farvid, MS, Fereshtehnejad, S-M, Fischer, F, Gebrehiwot, TT, Gutierrez, RA, Hafezi-Nejad, N, Hamadeh, RR, Hamidi, S, Haro, JM, Hendrie, D, Hu, G, Jonas, JB, Kasaeian, A, Keiyoro, PN, Khader, YS, Khan, EA, Khubchandani, J, Kopec, JA, Larson, HJ, Latif, AA, Leshargie, CT, Lunevicius, R, Abd El Razek, MM, Majeed, A, Malekzadeh, R, Memish, ZA, Meretoja, TJ, Miller, TR, Mohammed, S, Obermeyer, CM, Ogbo, FA, Phillips, MR, Pourmalek, F, Qorbani, M, Radfar, A, Rafay, A, Rahimi-Movaghar, A, Rahimi-Movaghar, V, Rai, RK, Rawaf, DL, Rawaf, S, Rezaei, S, Rezai, MS, Roshandel, G, Safdarian, M, Safiri, S, Salamati, P, Samy, AM, Sartorius, B, Seedat, S, Sepanlou, SG, Shaikh, MA, Sobaih, BHA, Tabb, KM, Tehrani-Banihashemi, A, Temsah, M-H, Terkawi, AS, RomanTopor-Madry, Ukwaja, KN, Uthman, OA, Yaseri, M, NaohiroYonemoto, Younis, MZ, Jumaan, AO, Vos, T, Hay, SI, Naghavi, M, and Murray, CJL
Abstract: OBJECTIVES: We used GBD 2015 findings to measure the burden of intentional injuries in the Eastern Mediterranean Region (EMR) between 1990 and 2015. METHODS: The Global Burden of Disease (GBD) study defines intentional injuries as a combination of self-harm (including suicide), interpersonal violence, collective violence (war), and legal intervention. We estimated number of deaths, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life years (DALYs) for each type of intentional injuries. RESULTS: In 2015, 28,695 individuals (95% UI: 25,474-37,832) died from self-harm, 35,626 (95% UI: 20,947-41,857) from interpersonal violence, and 143,858 (95% UI: 63,554-223,092) from collective violence and legal interventions. In 2015, collective violence and legal intervention was the fifth-leading cause of DALYs in the EMR and the leading cause in Syria, Yemen, Iraq, Afghanistan, and Libya; they account for 49.7% of total DALYs in Syria. CONCLUSIONS: Our findings call for increased efforts to stabilize the region and assist in rebuilding the health systems, as well as increasing transparency and employing preventive strategies to reduce self-harm and interpersonal injuries.
Published: 2018

19. Maternal mortality and morbidity burden in the Eastern Mediterranean Region: findings from the Global Burden of Disease 2015 study

Author: Mokdad, AH, Khalil, I, Collison, M, El Bcheraoui, C, Charara, R, Moradi-Lakeh, M, Afshin, A, Chew, A, Daoud, F, Krohn, KJ, Colombara, D, Ehrenkranz, R, Kutz, M, Wang, H, Abajobir, AA, Abd-Allah, F, Abraha, HN, Abu-Raddad, LJ, Kiadaliri, AA, Ahmadi, A, Ahmed, KY, Ahmed, MB, Al Lami, FH, Alam, K, Alasfoor, D, Alizadeh-Navaei, R, Alkaabi, JM, Al-Maskari, F, Al-Raddadi, R, Altirkawi, KA, Anber, N, Ansari, H, Asayesh, H, Asghar, RJ, Atey, TM, Ayele, TA, Baernighausen, T, Bacha, U, Barac, A, Barker-Collo, SL, Baune, BT, Bazargan-Hejazi, S, Geffen, D, Bedi, N, Bensenor, IM, Berhane, A, Beyene, AS, Bhutta, ZA, Boneya, DJ, Borschmann, R, Breitborde, NJK, Butt, ZA, Catala-Lopez, F, Ciobanu, LG, Danawi, H, Deribew, A, Dharmaratne, SD, Doyle, KE, Endries, AY, Faraon, EJA, Faro, A, Farvid, MS, Fekadu, W, Fereshtehnejad, S-M, Fischer, F, Gebrehiwot, TT, Giref, AZ, Gishu, MD, Goulart, AC, Habtewold, TD, Hamadeh, RR, Hambisa, MT, Hamidi, S, Maria Haro, J, Hassanvand, MS, Horita, N, Hsairi, M, Huang, H, Husseini, A, Jakovljevic, MB, James, SL, Jonas, JB, Kasaeian, A, Khader, YS, Khan, EA, Khoja, ATA, Khosravi, A, Khubchandani, J, Kim, D, Kim, YJ, Kokubo, Y, Koyanagi, A, Defo, BK, Larson, HJ, Latif, AA, Lee, PH, Leshargie, CT, Leung, R, Lo, L-T, Lunevicius, R, Abd El Razek, HM, Abd El Razek, MM, Majdzadeh, R, Majeed, A, Malekzadeh, R, Martinez-Raga, J, Farid, HM, Mazidi, M, McGrath, JJ, Memish, ZA, Mendoza, W, Mengesha, MM, Mengistie, MA, Mensah, GA, Mezgebe, HB, Miller, TR, Mitchell, PB, Mohammadi, A, Mohammed, S, Obermeyer, CM, Ogbo, FA, Palomares Castillo, E, Papachristou, C, Patten, SB, Patton, GC, Pereira, DM, Pervaiz, A, Phillips, MR, Pourmalek, F, Qorbani, M, Radfar, A, Rafay, A, Rahimi-Movaghar, V, Rai, RK, Rawaf, DL, Rawaf, S, Refaat, AH, Rezaei, S, Rezai, MS, Roshandel, G, Safdarian, M, Safiabadi, M, Safiri, S, Sagar, R, Sahraian, MA, Salamati, P, Samy, AM, Sartorius, B, Saylan, MI, Seedat, S, Sepanlou, SG, Shaikh, MA, Shamsizadeh, M, Santos Silva, DA, Singh, JA, Sobaih, BHA, Sreeramareddy, CT, Stein, DJ, Abdulkader, RS, Sykes, BL, Tabares-Seisdedos, R, Sufiyan, M, Tabb, KM, Tehrani-Banihashemi, A, Temsah, M-H, Terkawi, AS, Topor-Madry, R, Ukwaja, KN, Uthman, OA, Vollset, SE, Wakayo, T, Wang, Y-P, Werdecker, A, Westerman, R, Workicho, A, Yaghoubi, M, Yimam, HH, Yonemoto, N, Younis, MZ, Yu, C, Zaki, MES, Jumaan, AO, Vos, T, Hay, SI, Naghavi, M, Kassebaum, NJ, Murray, CJL, Mokdad, AH, Khalil, I, Collison, M, El Bcheraoui, C, Charara, R, Moradi-Lakeh, M, Afshin, A, Chew, A, Daoud, F, Krohn, KJ, Colombara, D, Ehrenkranz, R, Kutz, M, Wang, H, Abajobir, AA, Abd-Allah, F, Abraha, HN, Abu-Raddad, LJ, Kiadaliri, AA, Ahmadi, A, Ahmed, KY, Ahmed, MB, Al Lami, FH, Alam, K, Alasfoor, D, Alizadeh-Navaei, R, Alkaabi, JM, Al-Maskari, F, Al-Raddadi, R, Altirkawi, KA, Anber, N, Ansari, H, Asayesh, H, Asghar, RJ, Atey, TM, Ayele, TA, Baernighausen, T, Bacha, U, Barac, A, Barker-Collo, SL, Baune, BT, Bazargan-Hejazi, S, Geffen, D, Bedi, N, Bensenor, IM, Berhane, A, Beyene, AS, Bhutta, ZA, Boneya, DJ, Borschmann, R, Breitborde, NJK, Butt, ZA, Catala-Lopez, F, Ciobanu, LG, Danawi, H, Deribew, A, Dharmaratne, SD, Doyle, KE, Endries, AY, Faraon, EJA, Faro, A, Farvid, MS, Fekadu, W, Fereshtehnejad, S-M, Fischer, F, Gebrehiwot, TT, Giref, AZ, Gishu, MD, Goulart, AC, Habtewold, TD, Hamadeh, RR, Hambisa, MT, Hamidi, S, Maria Haro, J, Hassanvand, MS, Horita, N, Hsairi, M, Huang, H, Husseini, A, Jakovljevic, MB, James, SL, Jonas, JB, Kasaeian, A, Khader, YS, Khan, EA, Khoja, ATA, Khosravi, A, Khubchandani, J, Kim, D, Kim, YJ, Kokubo, Y, Koyanagi, A, Defo, BK, Larson, HJ, Latif, AA, Lee, PH, Leshargie, CT, Leung, R, Lo, L-T, Lunevicius, R, Abd El Razek, HM, Abd El Razek, MM, Majdzadeh, R, Majeed, A, Malekzadeh, R, Martinez-Raga, J, Farid, HM, Mazidi, M, McGrath, JJ, Memish, ZA, Mendoza, W, Mengesha, MM, Mengistie, MA, Mensah, GA, Mezgebe, HB, Miller, TR, Mitchell, PB, Mohammadi, A, Mohammed, S, Obermeyer, CM, Ogbo, FA, Palomares Castillo, E, Papachristou, C, Patten, SB, Patton, GC, Pereira, DM, Pervaiz, A, Phillips, MR, Pourmalek, F, Qorbani, M, Radfar, A, Rafay, A, Rahimi-Movaghar, V, Rai, RK, Rawaf, DL, Rawaf, S, Refaat, AH, Rezaei, S, Rezai, MS, Roshandel, G, Safdarian, M, Safiabadi, M, Safiri, S, Sagar, R, Sahraian, MA, Salamati, P, Samy, AM, Sartorius, B, Saylan, MI, Seedat, S, Sepanlou, SG, Shaikh, MA, Shamsizadeh, M, Santos Silva, DA, Singh, JA, Sobaih, BHA, Sreeramareddy, CT, Stein, DJ, Abdulkader, RS, Sykes, BL, Tabares-Seisdedos, R, Sufiyan, M, Tabb, KM, Tehrani-Banihashemi, A, Temsah, M-H, Terkawi, AS, Topor-Madry, R, Ukwaja, KN, Uthman, OA, Vollset, SE, Wakayo, T, Wang, Y-P, Werdecker, A, Westerman, R, Workicho, A, Yaghoubi, M, Yimam, HH, Yonemoto, N, Younis, MZ, Yu, C, Zaki, MES, Jumaan, AO, Vos, T, Hay, SI, Naghavi, M, Kassebaum, NJ, and Murray, CJL
Abstract: OBJECTIVES: Assessing the burden of maternal mortality is important for tracking progress and identifying public health gaps. This paper provides an overview of the burden of maternal mortality in the Eastern Mediterranean Region (EMR) by underlying cause and age from 1990 to 2015. METHODS: We used the results of the Global Burden of Disease 2015 study to explore maternal mortality in the EMR countries. RESULTS: The maternal mortality ratio in the EMR decreased 16.3% from 283 (241-328) maternal deaths per 100,000 live births in 1990 to 237 (188-293) in 2015. Maternal mortality ratio was strongly correlated with socio-demographic status, where the lowest-income countries contributed the most to the burden of maternal mortality in the region. CONCLUSION: Progress in reducing maternal mortality in the EMR has accelerated in the past 15 years, but the burden remains high. Coordinated and rigorous efforts are needed to make sure that adequate and timely services and interventions are available for women at each stage of reproductive life.
Published: 2018

20. Adolescent health in the Eastern Mediterranean Region: findings from the global burden of disease 2015 study

Author: Mokdad, AH, Azzopardi, P, Cini, K, Kennedy, E, Sawyer, S, El Bcheraoui, C, Charara, R, Khalil, I, Moradi-Lakeh, M, Collison, M, Afifi, RA, Al-Raiby, J, Krohn, KJ, Daoud, F, Chew, A, Afshin, A, Foreman, KJ, Kassebaum, NJ, Kutz, M, Kyu, HH, Liu, P, Olsen, HE, Smith, A, Stanaway, JD, Wang, H, Arnlov, J, Kiadaliri, AA, Alam, K, Alasfoor, D, Ali, R, Alizadeh-Navaei, R, Al-Raddadi, R, Altirkawi, KA, Alvis-Guzman, N, Anber, N, Antonio, CAT, Anwari, P, Artaman, A, Asayesh, H, Barker-Collo, SL, Bedi, N, Beghi, E, Bennett, DA, Bensenor, IM, Bhutta, ZA, Butt, ZA, Castaneda-Orjuela, CA, Catala-Lopez, F, Charlson, FJ, Danawi, H, De Leo, D, Degenhardt, L, Denno, D, Deribe, K, Jarlais, DCD, Dey, S, Dharmaratne, SD, Djalalinia, S, Erskine, HE, Fereshtehnejad, S-M, Ferrari, AJ, Fischer, F, Gebrehiwot, TT, Geleijnse, JM, Gona, PN, Gugnani, HC, Gupta, R, Hamadeh, RR, Hamidi, S, Maria Haro, J, Hay, RJ, Hearps, SJC, Hendrie, D, Hotez, PJ, Hu, G, Jonas, JB, Karch, A, Karimi, SM, Kasaeian, A, Kebede, S, Kengne, AP, Khan, EA, Khosravi, A, Khubchandani, J, Kokubo, Y, Kopec, JA, Kosen, S, Larson, HJ, Larsson, A, Leasher, JL, Leung, J, Li, Y, Lotufo, PA, Lunevicius, R, Abd El Razek, HM, Majdzadeh, R, Majeed, A, Memiah, P, Memish, ZA, Mendoza, W, Mhimbira, FA, Miller, TR, Mitchell, PB, Monasta, L, Obermeyer, CM, Oh, I-H, Olusanya, BO, Ortiz, A, Park, E-K, Parry, M, Pereira, DM, Phillips, MR, Pourmalek, F, Qorbani, M, Radfar, A, Rafay, A, Rahimi-Movaghar, V, Rai, RK, Rana, SM, Rawaf, DL, Rawaf, S, Reavley, N, Renzaho, AMN, Rezaei, S, Sadegh-Rezai, M, Rios-Zertuche, D, Roshandel, G, Rothenbacher, D, Safdarian, M, Safi, S, Safiri, S, Sahraian, MA, Salamati, P, Samy, AM, Sanabria, JR, Santomauro, D, Sartorius, B, Schwebel, DC, Seedat, S, Sepanlou, SG, Setegn, T, Shaheen, A, Shaikh, MA, Shiri, R, Sigfusdottir, ID, Singh, JA, Sobaih, BHA, Sreeramareddy, CT, Abdulkader, RS, Tehrani-Banihashemi, A, Temsah, M-H, Terkawi, AS, Thomson, AJ, Tonelli, M, Topor-Madry, R, Tran, BX, Ukwaja, KN, Uthman, OA, Vasankari, T, Venketasubramanian, N, Vlassov, VV, Vollset, SE, Weiderpass, E, Weintraub, RG, Werdecker, A, Whiteford, HA, Yano, Y, Yaseri, M, Yonemoto, N, Younis, MZ, Yu, C, Jumaan, AO, Vos, T, Hay, SI, Naghavi, M, Patton, GC, Murray, CJL, Mokdad, AH, Azzopardi, P, Cini, K, Kennedy, E, Sawyer, S, El Bcheraoui, C, Charara, R, Khalil, I, Moradi-Lakeh, M, Collison, M, Afifi, RA, Al-Raiby, J, Krohn, KJ, Daoud, F, Chew, A, Afshin, A, Foreman, KJ, Kassebaum, NJ, Kutz, M, Kyu, HH, Liu, P, Olsen, HE, Smith, A, Stanaway, JD, Wang, H, Arnlov, J, Kiadaliri, AA, Alam, K, Alasfoor, D, Ali, R, Alizadeh-Navaei, R, Al-Raddadi, R, Altirkawi, KA, Alvis-Guzman, N, Anber, N, Antonio, CAT, Anwari, P, Artaman, A, Asayesh, H, Barker-Collo, SL, Bedi, N, Beghi, E, Bennett, DA, Bensenor, IM, Bhutta, ZA, Butt, ZA, Castaneda-Orjuela, CA, Catala-Lopez, F, Charlson, FJ, Danawi, H, De Leo, D, Degenhardt, L, Denno, D, Deribe, K, Jarlais, DCD, Dey, S, Dharmaratne, SD, Djalalinia, S, Erskine, HE, Fereshtehnejad, S-M, Ferrari, AJ, Fischer, F, Gebrehiwot, TT, Geleijnse, JM, Gona, PN, Gugnani, HC, Gupta, R, Hamadeh, RR, Hamidi, S, Maria Haro, J, Hay, RJ, Hearps, SJC, Hendrie, D, Hotez, PJ, Hu, G, Jonas, JB, Karch, A, Karimi, SM, Kasaeian, A, Kebede, S, Kengne, AP, Khan, EA, Khosravi, A, Khubchandani, J, Kokubo, Y, Kopec, JA, Kosen, S, Larson, HJ, Larsson, A, Leasher, JL, Leung, J, Li, Y, Lotufo, PA, Lunevicius, R, Abd El Razek, HM, Majdzadeh, R, Majeed, A, Memiah, P, Memish, ZA, Mendoza, W, Mhimbira, FA, Miller, TR, Mitchell, PB, Monasta, L, Obermeyer, CM, Oh, I-H, Olusanya, BO, Ortiz, A, Park, E-K, Parry, M, Pereira, DM, Phillips, MR, Pourmalek, F, Qorbani, M, Radfar, A, Rafay, A, Rahimi-Movaghar, V, Rai, RK, Rana, SM, Rawaf, DL, Rawaf, S, Reavley, N, Renzaho, AMN, Rezaei, S, Sadegh-Rezai, M, Rios-Zertuche, D, Roshandel, G, Rothenbacher, D, Safdarian, M, Safi, S, Safiri, S, Sahraian, MA, Salamati, P, Samy, AM, Sanabria, JR, Santomauro, D, Sartorius, B, Schwebel, DC, Seedat, S, Sepanlou, SG, Setegn, T, Shaheen, A, Shaikh, MA, Shiri, R, Sigfusdottir, ID, Singh, JA, Sobaih, BHA, Sreeramareddy, CT, Abdulkader, RS, Tehrani-Banihashemi, A, Temsah, M-H, Terkawi, AS, Thomson, AJ, Tonelli, M, Topor-Madry, R, Tran, BX, Ukwaja, KN, Uthman, OA, Vasankari, T, Venketasubramanian, N, Vlassov, VV, Vollset, SE, Weiderpass, E, Weintraub, RG, Werdecker, A, Whiteford, HA, Yano, Y, Yaseri, M, Yonemoto, N, Younis, MZ, Yu, C, Jumaan, AO, Vos, T, Hay, SI, Naghavi, M, Patton, GC, and Murray, CJL
Abstract: OBJECTIVES: The 22 countries of the East Mediterranean Region (EMR) have large populations of adolescents aged 10-24 years. These adolescents are central to assuring the health, development, and peace of this region. We described their health needs. METHODS: Using data from the Global Burden of Disease Study 2015 (GBD 2015), we report the leading causes of mortality and morbidity for adolescents in the EMR from 1990 to 2015. We also report the prevalence of key health risk behaviors and determinants. RESULTS: Communicable diseases and the health consequences of natural disasters reduced substantially between 1990 and 2015. However, these gains have largely been offset by the health impacts of war and the emergence of non-communicable diseases (including mental health disorders), unintentional injury, and self-harm. Tobacco smoking and high body mass were common health risks amongst adolescents. Additionally, many EMR countries had high rates of adolescent pregnancy and unmet need for contraception. CONCLUSIONS: Even with the return of peace and security, adolescents will have a persisting poor health profile that will pose a barrier to socioeconomic growth and development of the EMR.
Published: 2018

21. Burden of vision loss in the Eastern Mediterranean region, 1990-2015: findings from the Global Burden of Disease 2015 study

Author: Mokdad, AH, Safi, S, Ahmadieh, H, Katibeh, M, Yaseri, M, Ramezani, A, Shahraz, S, Moradi-Lakeh, M, Khalil, I, El Bcheraoui, C, Collison, M, Chew, A, Daoud, F, Krohn, KJ, Rankin, Z, Afshin, A, Kassebaum, NJ, Olsen, HE, Stanaway, JD, Wang, H, Wilson, K, Yitayih, G, Al-Eyadhy, A, Alam, K, Alasfoor, D, Alizadeh-Navaei, R, Al-Raddadi, R, Alsharif, U, Altirkawi, KA, Anber, N, Ansari, H, Anwari, P, Asayesh, H, Asgedom, SW, Atey, TM, Bacha, U, Barac, A, Bedi, N, Butt, ZA, Chitheer, AA, Djalalinia, S, Huyen, DP, Eshrati, B, Farvid, MS, Farzadfar, F, Fereshtehnejad, S-M, Fischer, F, Gebrehiwot, TT, Hamadeh, RR, Hamidi, S, Higazi, TB, Hsairi, M, Jimenez-Corona, A, John, D, Jonas, JB, Kasaeian, A, Saleh, Y, Khan, EA, Larson, HJ, Latif, AA, Lunevicius, R, Abd El Razek, HM, Abd El Razek, MM, Majeed, A, Malekzadeh, R, McAlinden, C, Memish, ZA, Miller, TR, Mohammadi, S-F, Nangia, V, Cuong, TN, Quyen, LN, Ogbo, FA, Pourmalek, F, Qorbani, M, Rafay, A, Rahimi-Movaghar, V, Rai, RK, Rana, SM, Rawaf, DL, Rawaf, S, Renzaho, AMN, Rezaei, S, Roshandel, G, Safdarian, M, Safiri, S, Salamati, P, Samy, AM, Sartorius, B, Sepanlou, SG, Shaikh, MA, Skiadaresi, E, Sobaih, BHA, Abdulkader, RS, Taylor, HR, Tehrani-Banihashemi, A, Temsah, M-H, Topor-Madry, R, Xuan, B, Tsilimbaris, M, Ukwaja, KN, Uthman, OA, Wakayo, T, Yonemoto, N, Younis, MZ, Zaki, MES, Jumaan, AO, Vos, T, Hay, SI, Naghavi, M, Murray, CJL, Mokdad, AH, Safi, S, Ahmadieh, H, Katibeh, M, Yaseri, M, Ramezani, A, Shahraz, S, Moradi-Lakeh, M, Khalil, I, El Bcheraoui, C, Collison, M, Chew, A, Daoud, F, Krohn, KJ, Rankin, Z, Afshin, A, Kassebaum, NJ, Olsen, HE, Stanaway, JD, Wang, H, Wilson, K, Yitayih, G, Al-Eyadhy, A, Alam, K, Alasfoor, D, Alizadeh-Navaei, R, Al-Raddadi, R, Alsharif, U, Altirkawi, KA, Anber, N, Ansari, H, Anwari, P, Asayesh, H, Asgedom, SW, Atey, TM, Bacha, U, Barac, A, Bedi, N, Butt, ZA, Chitheer, AA, Djalalinia, S, Huyen, DP, Eshrati, B, Farvid, MS, Farzadfar, F, Fereshtehnejad, S-M, Fischer, F, Gebrehiwot, TT, Hamadeh, RR, Hamidi, S, Higazi, TB, Hsairi, M, Jimenez-Corona, A, John, D, Jonas, JB, Kasaeian, A, Saleh, Y, Khan, EA, Larson, HJ, Latif, AA, Lunevicius, R, Abd El Razek, HM, Abd El Razek, MM, Majeed, A, Malekzadeh, R, McAlinden, C, Memish, ZA, Miller, TR, Mohammadi, S-F, Nangia, V, Cuong, TN, Quyen, LN, Ogbo, FA, Pourmalek, F, Qorbani, M, Rafay, A, Rahimi-Movaghar, V, Rai, RK, Rana, SM, Rawaf, DL, Rawaf, S, Renzaho, AMN, Rezaei, S, Roshandel, G, Safdarian, M, Safiri, S, Salamati, P, Samy, AM, Sartorius, B, Sepanlou, SG, Shaikh, MA, Skiadaresi, E, Sobaih, BHA, Abdulkader, RS, Taylor, HR, Tehrani-Banihashemi, A, Temsah, M-H, Topor-Madry, R, Xuan, B, Tsilimbaris, M, Ukwaja, KN, Uthman, OA, Wakayo, T, Yonemoto, N, Younis, MZ, Zaki, MES, Jumaan, AO, Vos, T, Hay, SI, Naghavi, M, and Murray, CJL
Abstract: OBJECTIVES: To report the estimated trend in prevalence and years lived with disability (YLDs) due to vision loss (VL) in the Eastern Mediterranean region (EMR) from 1990 to 2015. METHODS: The estimated trends in age-standardized prevalence and the YLDs rate due to VL in 22 EMR countries were extracted from the Global Burden of Disease (GBD) 2015 study. The association of Socio-demographic Index (SDI) with changes in prevalence and YLDs of VL was evaluated using a multilevel mixed model. RESULTS: The age-standardized prevalence of VL in the EMR was 18.2% in 1990 and 15.5% in 2015. The total age-standardized YLDs rate attributed to all-cause VL in EMR was 536.9 per 100,000 population in 1990 and 482.3 per 100,000 population in 2015. For each 0.1 unit increase in SDI, the age-standardized prevalence and YLDs rate of VL showed a reduction of 1.5% (p < 0.001) and 23.9 per 100,000 population (p < 0.001), respectively. CONCLUSIONS: The burden of VL is high in the EMR; however, it shows a descending trend over the past 25 years. EMR countries need to establish comprehensive eye care programs in their health care systems.
Published: 2018

22. The burden of mental disorders in the Eastern Mediterranean region, 1990-2015: findings from the global burden of disease 2015 study

Author: Mokdad, AH, Charara, R, El Bcheraoui, C, Khalil, I, Moradi-Lakeh, M, Afshin, A, Kassebaum, NJ, Collison, M, Krohn, KJ, Chew, A, Daoud, F, Charlson, FJ, Colombara, D, Degenhardt, L, Ehrenkranz, R, Erskine, HE, Ferrari, AJ, Kutz, M, Leung, J, Santomauro, D, Wang, H, Whiteford, HA, Abajobir, AA, Abd-Allah, F, Abraha, HN, Abu-Raddad, LJ, Kiadaliri, AA, Ahmadi, A, Yimam, K, Beshir, M, Al Lami, FH, Alam, K, Alasfoor, D, Alizadeh-Navaei, R, Alkaabi, JM, Al-Maskari, F, Al-Raddadi, R, Altirkawi, KA, Anber, N, Ansari, H, Asayesh, H, Asghar, RJ, Atey, TM, Ayele, TA, Baernighausen, T, Bacha, U, Barac, A, Barker-Collo, SL, Baune, BT, Bazargan-Hejazi, S, Drew, CR, Geffen, D, Bedi, N, Bensenor, IM, Berhane, A, Beyene, AS, Bhutta, ZA, Boneya, DJ, Borschmann, R, Breitborde, NJK, Butt, ZA, Catala-Lopez, F, Ciobanu, LG, Danawi, H, Deribew, A, Dharmaratne, SD, Doyle, KE, Endries, AY, Faraon, EJA, Faro, A, Farvid, MS, Fekadu, W, Fereshtehnejad, S-M, Fischer, F, Gebrehiwot, TT, Giref, AZ, Gishu, MD, Carvalho, A, Habtewold, TD, Hamadeh, RR, Hambisa, MT, Hamidi, S, Haro, JM, Hassanvand, MS, Horita, N, Hsairi, M, Huang, H, Husseini, A, Jakovljevic, MB, James, SL, Jonas, JB, Kasaeian, A, Khader, YS, Khan, EA, Khoja, ATA, Khosravi, A, Khubchandani, J, Kim, D, Kim, YJ, Kokubo, Y, Koyanagi, A, Defo, BK, Larson, HJ, Latif, AA, Lee, PH, Leshargie, CT, Leung, R, Lo, L-T, Lunevicius, R, Abd El Razek, HM, Abd El Razek, MM, Majdzadeh, R, Majeed, A, Malekzadeh, R, Martinez-Raga, J, Farid, HM, Mazidi, M, McGrath, JJ, Memish, ZA, Mendoza, W, Mengesha, MM, Mengistie, MA, Mezgebe, HB, Miller, TR, Mitchell, PB, Mohammadi, A, Mohammed, S, Obermeyer, CM, Ogbo, FA, Castillo, EP, Papachristou, C, Patten, SB, Patton, GC, Pervaiz, A, Phillips, MR, Pourmalek, F, Qorbani, M, Radfar, A, Rafay, A, Rahimi-Movaghar, V, Rai, RK, Rawaf, DL, Rawaf, S, Refaat, AH, Rezaei, S, Rezai, MS, Roshandel, G, Safdarian, M, Safiabadi, M, Safiri, S, Sagar, R, Sahraian, MA, Salamati, P, Samy, AM, Sartorius, B, Saylan, MI, Seedat, S, Sepanlou, SG, Shaikh, MA, Shamsizadeh, M, Silva, DAS, Singh, JA, Sobaih, BHA, Stein, DJ, Abdulkader, RS, Sykes, BL, Tabares-Seisdedos, R, Tabb, KM, Tehrani-Banihashemi, A, Temsah, M-H, Terkawi, AS, Topor-Madry, R, Ukwaja, KN, Uthman, OA, Vollset, SE, Wakayo, T, Wang, Y-P, Werdecker, A, Westerman, R, Workicho, A, Yaghoubi, M, Yimam, HH, Yonemoto, N, Younis, MZ, Yu, C, Zaki, MES, Zein, B, Jumaan, AO, Vos, T, Hay, SI, Naghavi, M, Murray, CJL, Mokdad, AH, Charara, R, El Bcheraoui, C, Khalil, I, Moradi-Lakeh, M, Afshin, A, Kassebaum, NJ, Collison, M, Krohn, KJ, Chew, A, Daoud, F, Charlson, FJ, Colombara, D, Degenhardt, L, Ehrenkranz, R, Erskine, HE, Ferrari, AJ, Kutz, M, Leung, J, Santomauro, D, Wang, H, Whiteford, HA, Abajobir, AA, Abd-Allah, F, Abraha, HN, Abu-Raddad, LJ, Kiadaliri, AA, Ahmadi, A, Yimam, K, Beshir, M, Al Lami, FH, Alam, K, Alasfoor, D, Alizadeh-Navaei, R, Alkaabi, JM, Al-Maskari, F, Al-Raddadi, R, Altirkawi, KA, Anber, N, Ansari, H, Asayesh, H, Asghar, RJ, Atey, TM, Ayele, TA, Baernighausen, T, Bacha, U, Barac, A, Barker-Collo, SL, Baune, BT, Bazargan-Hejazi, S, Drew, CR, Geffen, D, Bedi, N, Bensenor, IM, Berhane, A, Beyene, AS, Bhutta, ZA, Boneya, DJ, Borschmann, R, Breitborde, NJK, Butt, ZA, Catala-Lopez, F, Ciobanu, LG, Danawi, H, Deribew, A, Dharmaratne, SD, Doyle, KE, Endries, AY, Faraon, EJA, Faro, A, Farvid, MS, Fekadu, W, Fereshtehnejad, S-M, Fischer, F, Gebrehiwot, TT, Giref, AZ, Gishu, MD, Carvalho, A, Habtewold, TD, Hamadeh, RR, Hambisa, MT, Hamidi, S, Haro, JM, Hassanvand, MS, Horita, N, Hsairi, M, Huang, H, Husseini, A, Jakovljevic, MB, James, SL, Jonas, JB, Kasaeian, A, Khader, YS, Khan, EA, Khoja, ATA, Khosravi, A, Khubchandani, J, Kim, D, Kim, YJ, Kokubo, Y, Koyanagi, A, Defo, BK, Larson, HJ, Latif, AA, Lee, PH, Leshargie, CT, Leung, R, Lo, L-T, Lunevicius, R, Abd El Razek, HM, Abd El Razek, MM, Majdzadeh, R, Majeed, A, Malekzadeh, R, Martinez-Raga, J, Farid, HM, Mazidi, M, McGrath, JJ, Memish, ZA, Mendoza, W, Mengesha, MM, Mengistie, MA, Mezgebe, HB, Miller, TR, Mitchell, PB, Mohammadi, A, Mohammed, S, Obermeyer, CM, Ogbo, FA, Castillo, EP, Papachristou, C, Patten, SB, Patton, GC, Pervaiz, A, Phillips, MR, Pourmalek, F, Qorbani, M, Radfar, A, Rafay, A, Rahimi-Movaghar, V, Rai, RK, Rawaf, DL, Rawaf, S, Refaat, AH, Rezaei, S, Rezai, MS, Roshandel, G, Safdarian, M, Safiabadi, M, Safiri, S, Sagar, R, Sahraian, MA, Salamati, P, Samy, AM, Sartorius, B, Saylan, MI, Seedat, S, Sepanlou, SG, Shaikh, MA, Shamsizadeh, M, Silva, DAS, Singh, JA, Sobaih, BHA, Stein, DJ, Abdulkader, RS, Sykes, BL, Tabares-Seisdedos, R, Tabb, KM, Tehrani-Banihashemi, A, Temsah, M-H, Terkawi, AS, Topor-Madry, R, Ukwaja, KN, Uthman, OA, Vollset, SE, Wakayo, T, Wang, Y-P, Werdecker, A, Westerman, R, Workicho, A, Yaghoubi, M, Yimam, HH, Yonemoto, N, Younis, MZ, Yu, C, Zaki, MES, Zein, B, Jumaan, AO, Vos, T, Hay, SI, Naghavi, M, and Murray, CJL
Abstract: OBJECTIVES: Mental disorders are among the leading causes of nonfatal burden of disease globally. METHODS: We used the global burden of diseases, injuries, and risk factors study 2015 to examine the burden of mental disorders in the Eastern Mediterranean region (EMR). We defined mental disorders according to criteria proposed in the diagnostic and statistical manual of mental disorders IV and the 10th International Classification of Diseases. RESULTS: Mental disorders contributed to 4.7% (95% uncertainty interval (UI) 3.7-5.6%) of total disability-adjusted life-years (DALYs), ranking as the ninth leading cause of disease burden. Depressive disorders and anxiety disorders were the third and ninth leading causes of nonfatal burden, respectively. Almost all countries in the EMR had higher age-standardized mental disorder DALYs rates compared to the global level, and in half of the EMR countries, observed mental disorder rates exceeded the expected values. CONCLUSIONS: The burden of mental disorders in the EMR is higher than global levels, particularly for women. To properly address this burden, EMR governments should implement nationwide quality epidemiological surveillance of mental disorders and provide adequate prevention and treatment services.
Published: 2018

23. Global, regional, and national burden of Parkinson's disease, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016

Author: Dorsey, ER, Elbaz, A, Nichols, E, Abd-Allah, F, Abdelalim, A, Adsuar, JC, Ansha, MG, Brayne, C, Choi, J-YJ, Collado-Mateo, D, Dahodwala, N, Huyen, PD, Edessa, D, Endres, M, Fereshtehnejad, S-M, Foreman, KJ, Gbetoho Gankpe, F, Gupta, R, Hankey, GJ, Hay, SI, Hegazy, MI, Hibstu, DT, Kasaeian, A, Khader, Y, Khalil, I, Khang, Y-H, Kim, YJ, Kokubo, Y, Logroscino, G, Massano, J, Ibrahim, NM, Mohammed, AM, Mohammadi, A, Moradi-Lakeh, M, Naghavi, M, Binh, TN, Nirayo, YL, Ogbo, FA, Owolabi, MO, Pereira, DM, Postma, MJ, Qorbani, M, Rahman, MA, Roba, KT, Safari, H, Safiri, S, Satpathy, M, Sawhney, M, Shafieesabet, A, Shiferaw, MS, Smith, M, Szoeke, CEI, Tabares-Seisdedos, R, Nu, TT, Ukwaja, KN, Venketasubramanian, N, Villafaina, S, Weldegwergs, KG, Westerman, R, Wijeratne, T, Winkler, AS, Bach, TX, Yonemoto, N, Feigin, VL, Vos, T, Murray, CJL, Dorsey, ER, Elbaz, A, Nichols, E, Abd-Allah, F, Abdelalim, A, Adsuar, JC, Ansha, MG, Brayne, C, Choi, J-YJ, Collado-Mateo, D, Dahodwala, N, Huyen, PD, Edessa, D, Endres, M, Fereshtehnejad, S-M, Foreman, KJ, Gbetoho Gankpe, F, Gupta, R, Hankey, GJ, Hay, SI, Hegazy, MI, Hibstu, DT, Kasaeian, A, Khader, Y, Khalil, I, Khang, Y-H, Kim, YJ, Kokubo, Y, Logroscino, G, Massano, J, Ibrahim, NM, Mohammed, AM, Mohammadi, A, Moradi-Lakeh, M, Naghavi, M, Binh, TN, Nirayo, YL, Ogbo, FA, Owolabi, MO, Pereira, DM, Postma, MJ, Qorbani, M, Rahman, MA, Roba, KT, Safari, H, Safiri, S, Satpathy, M, Sawhney, M, Shafieesabet, A, Shiferaw, MS, Smith, M, Szoeke, CEI, Tabares-Seisdedos, R, Nu, TT, Ukwaja, KN, Venketasubramanian, N, Villafaina, S, Weldegwergs, KG, Westerman, R, Wijeratne, T, Winkler, AS, Bach, TX, Yonemoto, N, Feigin, VL, Vos, T, and Murray, CJL
Abstract: BACKGROUND: Neurological disorders are now the leading source of disability globally, and ageing is increasing the burden of neurodegenerative disorders, including Parkinson's disease. We aimed to determine the global burden of Parkinson's disease between 1990 and 2016 to identify trends and to enable appropriate public health, medical, and scientific responses. METHODS: Through a systematic analysis of epidemiological studies, we estimated global, regional, and country-specific prevalence and years of life lived with disability for Parkinson's disease from 1990 to 2016. We estimated the proportion of mild, moderate, and severe Parkinson's disease on the basis of studies that used the Hoehn and Yahr scale and assigned disability weights to each level. We jointly modelled prevalence and excess mortality risk in a natural history model to derive estimates of deaths due to Parkinson's disease. Death counts were multiplied by values from the Global Burden of Disease study's standard life expectancy to compute years of life lost. Disability-adjusted life-years (DALYs) were computed as the sum of years lived with disability and years of life lost. We also analysed results based on the Socio-demographic Index, a compound measure of income per capita, education, and fertility. FINDINGS: In 2016, 6·1 million (95% uncertainty interval [UI] 5·0-7·3) individuals had Parkinson's disease globally, compared with 2·5 million (2·0-3·0) in 1990. This increase was not solely due to increasing numbers of older people, because age-standardised prevalence rates increased by 21·7% (95% UI 18·1-25·3) over the same period (compared with an increase of 74·3%, 95% UI 69·2-79·6, for crude prevalence rates). Parkinson's disease caused 3·2 million (95% UI 2·6-4·0) DALYs and 211 296 deaths (95% UI 167 771-265 160) in 2016. The male-to-female ratios of age-standardised prevalence rates were similar in 2016 (1·40, 95% UI 1·36-1·43) and 1990 (1·37, 1·34-1·40). From 1990 to 2016, age-standardised pre
Published: 2018

24. Burden of cancer in the Eastern Mediterranean Region, 2005-2015: findings from the Global Burden of Disease 2015 Study

Author: Fitzmaurice, C, Alsharif, U, El Bcheraoui, C, Khalil, I, Charara, R, Moradi-Lakeh, M, Afshin, A, Collison, M, Chew, A, Krohn, KJ, Daoud, F, Dicker, D, Foreman, KJ, Frostad, J, Kassebaum, NJ, Kutz, M, Wang, H, Abyu, GY, Adedeji, IA, Kiadaliri, AA, Ahmed, MB, Al-Eyadhy, A, Alam, K, Alasfoor, D, Ali, R, Alizadeh-Navaei, R, Al-Raddadi, R, Altirkawi, KA, Alvis-Guzman, N, Amini, E, Anber, N, Anwari, P, Artaman, A, Asgedom, SW, Atey, TM, Awasthi, A, Saleem, HOB, Bacha, U, Barac, A, Bedi, N, Bhutta, ZA, Butt, ZA, Castaneda-Orjuela, CA, Chitheer, AA, Danawi, H, das Neves, J, Davitoiu, DV, Dey, S, Dharmaratne, SD, Djalalinia, S, Huyen, PD, Dubey, M, Ebrahimi, H, Ekwueme, DU, Endries, AY, Eshrati, B, Esteghamati, A, Farvid, MS, Fereshtehnejad, S-M, Fischer, F, Gebrehiwot, TT, Gopalani, SV, Hafezi-Nejad, N, Hamadeh, RR, Hamidi, S, Hareri, HA, Hay, RJ, Horita, N, Hsairi, M, Jakovljevic, MB, Jonas, JB, Kasaeian, A, Kassaw, NA, Khader, YS, Khan, EA, Khan, G, Kim, D, Kinfu, Y, Larson, HJ, Latif, AA, Linn, S, Lunevicius, R, Abd El Razek, HM, Abd El Razek, MM, Majeed, A, Malekzadeh, R, Malta, DC, Markos, D, Memiah, P, Memish, ZA, Mendoza, W, Meretoja, TJ, Miller, TR, Mohammed, S, Nangia, V, Quyen, LN, Trang, HN, Ogbo, FA, Mahesh, PA, Park, E-K, Patel, T, Pereira, DM, Pishgar, F, Pourmalek, F, Qorbani, M, Radfar, A, Rafay, A, Rahimi-Movaghar, V, Rai, RK, Rana, SM, Rawaf, S, Renzaho, AMN, Rezaei, S, Roba, KT, Roshandel, G, Safdarian, M, Safi, S, Safiri, S, Salamati, P, Samy, AM, Sanabria, JR, Milicevic, MMS, Sartorius, B, Sepanlou, SG, Shaikh, MA, Shrime, MG, Stathopoulou, V, Sufiyan, MB, Abdulkader, RS, Tabares-Seisdedos, R, Tehrani-Banihashemi, A, Tekelab, T, Temsah, M-H, Tran, BX, Ukwaja, KN, Uthman, OA, Vlassov, VV, Vollset, SE, Wakayo, T, Weiderpass, E, Werdecker, A, Yaghoubi, M, Yaseri, M, Yimam, HH, Yonemoto, N, Zaki, MES, Zein, B, Jumaan, AO, Vos, T, Hay, SI, Naghavi, M, Murray, CJL, Mokdad, AH, Fitzmaurice, C, Alsharif, U, El Bcheraoui, C, Khalil, I, Charara, R, Moradi-Lakeh, M, Afshin, A, Collison, M, Chew, A, Krohn, KJ, Daoud, F, Dicker, D, Foreman, KJ, Frostad, J, Kassebaum, NJ, Kutz, M, Wang, H, Abyu, GY, Adedeji, IA, Kiadaliri, AA, Ahmed, MB, Al-Eyadhy, A, Alam, K, Alasfoor, D, Ali, R, Alizadeh-Navaei, R, Al-Raddadi, R, Altirkawi, KA, Alvis-Guzman, N, Amini, E, Anber, N, Anwari, P, Artaman, A, Asgedom, SW, Atey, TM, Awasthi, A, Saleem, HOB, Bacha, U, Barac, A, Bedi, N, Bhutta, ZA, Butt, ZA, Castaneda-Orjuela, CA, Chitheer, AA, Danawi, H, das Neves, J, Davitoiu, DV, Dey, S, Dharmaratne, SD, Djalalinia, S, Huyen, PD, Dubey, M, Ebrahimi, H, Ekwueme, DU, Endries, AY, Eshrati, B, Esteghamati, A, Farvid, MS, Fereshtehnejad, S-M, Fischer, F, Gebrehiwot, TT, Gopalani, SV, Hafezi-Nejad, N, Hamadeh, RR, Hamidi, S, Hareri, HA, Hay, RJ, Horita, N, Hsairi, M, Jakovljevic, MB, Jonas, JB, Kasaeian, A, Kassaw, NA, Khader, YS, Khan, EA, Khan, G, Kim, D, Kinfu, Y, Larson, HJ, Latif, AA, Linn, S, Lunevicius, R, Abd El Razek, HM, Abd El Razek, MM, Majeed, A, Malekzadeh, R, Malta, DC, Markos, D, Memiah, P, Memish, ZA, Mendoza, W, Meretoja, TJ, Miller, TR, Mohammed, S, Nangia, V, Quyen, LN, Trang, HN, Ogbo, FA, Mahesh, PA, Park, E-K, Patel, T, Pereira, DM, Pishgar, F, Pourmalek, F, Qorbani, M, Radfar, A, Rafay, A, Rahimi-Movaghar, V, Rai, RK, Rana, SM, Rawaf, S, Renzaho, AMN, Rezaei, S, Roba, KT, Roshandel, G, Safdarian, M, Safi, S, Safiri, S, Salamati, P, Samy, AM, Sanabria, JR, Milicevic, MMS, Sartorius, B, Sepanlou, SG, Shaikh, MA, Shrime, MG, Stathopoulou, V, Sufiyan, MB, Abdulkader, RS, Tabares-Seisdedos, R, Tehrani-Banihashemi, A, Tekelab, T, Temsah, M-H, Tran, BX, Ukwaja, KN, Uthman, OA, Vlassov, VV, Vollset, SE, Wakayo, T, Weiderpass, E, Werdecker, A, Yaghoubi, M, Yaseri, M, Yimam, HH, Yonemoto, N, Zaki, MES, Zein, B, Jumaan, AO, Vos, T, Hay, SI, Naghavi, M, Murray, CJL, and Mokdad, AH
Abstract: OBJECTIVES: To estimate incidence, mortality, and disability-adjusted life years (DALYs) caused by cancer in the Eastern Mediterranean Region (EMR) between 2005 and 2015. METHODS: Vital registration system and cancer registry data from the EMR region were analyzed for 29 cancer groups in 22 EMR countries using the Global Burden of Disease Study 2015 methodology. RESULTS: In 2015, cancer was responsible for 9.4% of all deaths and 5.1% of all DALYs. It accounted for 722,646 new cases, 379,093 deaths, and 11.7 million DALYs. Between 2005 and 2015, incident cases increased by 46%, deaths by 33%, and DALYs by 31%. The increase in cancer incidence was largely driven by population growth and population aging. Breast cancer, lung cancer, and leukemia were the most common cancers, while lung, breast, and stomach cancers caused most cancer deaths. CONCLUSIONS: Cancer is responsible for a substantial disease burden in the EMR, which is increasing. There is an urgent need to expand cancer prevention, screening, and awareness programs in EMR countries as well as to improve diagnosis, treatment, and palliative care services.
Published: 2018

25. Neonatal, infant, and under-5 mortality and morbidity burden in the Eastern Mediterranean region: findings from the Global Burden of Disease 2015 study

Author: Mokdad, AH, Khalil, I, Collison, M, El Bcheraoui, C, Charara, R, Moradi-Lakeh, M, Afshin, A, Krohn, KJ, Daoud, F, Chew, A, Kassebaum, NJ, Colombara, D, Cornaby, L, Ehrenkranz, R, Foreman, KJ, Fraser, M, Frostad, J, Kemmer, L, Kulikoff, XR, Kutz, M, Kyu, HH, Liu, P, Mikesell, J, Nguyen, G, Rao, PC, Silpakit, N, Sligar, A, Smith, A, Stanaway, JD, Arnlov, J, Abate, KH, Kiadaliri, AA, Alam, K, Alasfoor, D, Ali, R, Alizadeh-Navaei, R, Alraddadi, R, Altirkawi, KA, Alvis-Guzman, N, Anber, N, Ansari, H, Antonio, CAT, Anwari, P, Artaman, A, Asayesh, H, Asgedom, SW, Azzopardi, P, Bacha, U, Barac, A, Barker-Collo, SL, Bedi, N, Beghi, E, Bennett, DA, Bhutta, ZA, Bisanzio, D, Castaneda-Orjuela, CA, Estanislao Castro, R, Danawi, H, Deribe, K, Deribew, A, Jarlais, DCD, deVeber, GA, Dey, S, Dharmaratne, SD, Djalalinia, S, Huyen, PD, Esteghamati, A, Farvid, MS, Fereshtehnejad, S-M, Fischer, F, Gebrehiwot, TT, Giussani, G, Gona, PN, Hafezi-Nejad, N, Hamadeh, RR, Hamidi, S, Hoy, DG, Hu, G, John, D, Jonas, JB, Karimi, SM, Kasaeian, A, Khader, YS, Khan, EA, Khan, G, Kim, D, Kim, YJ, Kinfu, Y, Larson, HJ, Latif, AA, Leasher, JL, Lunevicius, R, Abd El Razek, HM, Abd El Razek, MM, Majeed, A, Malekzadeh, R, Memish, ZA, Mendoza, W, Mezgebe, HB, Miller, TR, Monasta, L, Quyen, LN, Obermeyer, CM, Ortiz, A, Papachristou, C, Park, E-K, Pereira, CC, Petzold, M, Pereira, DM, Phillips, MR, Pourmalek, F, Qorbani, M, Rafay, A, Rahimi-Movaghar, V, Rai, RK, Rana, SM, Rawaf, DL, Rawaf, S, Renzaho, AMN, Rezaei, S, Rezai, MS, Ronfani, L, Roshandel, G, Ruhago, GM, Safdarian, M, Safiri, S, Sahraian, MA, Salamati, P, Samy, AM, Sanabria, JR, Sartorius, B, Schwebel, DC, Seedat, S, Sepanlou, SG, Setegn, T, Shaheen, A, Shaikh, MA, Shamsizadeh, M, Shiri, R, Skirbekk, V, Sobaih, BHA, Sreeramareddy, CT, Stathopoulou, V, Abdulkader, RS, Tehrani-Banihashemi, A, Temsah, M-H, Thakur, AJS, Thomson, AJ, Tran, BX, Truelsen, T, Ukwaja, KN, Uthman, OA, Vasankari, T, Vlassov, VV, Weiderpass, E, Weintraub, RG, Werdecker, A, Yaghoubi, M, Yaseri, M, Yonemoto, N, Younis, MZ, Yu, C, Jumaan, AO, Vos, T, Hay, SI, Naghavi, M, Wang, H, Murray, CJL, Mokdad, AH, Khalil, I, Collison, M, El Bcheraoui, C, Charara, R, Moradi-Lakeh, M, Afshin, A, Krohn, KJ, Daoud, F, Chew, A, Kassebaum, NJ, Colombara, D, Cornaby, L, Ehrenkranz, R, Foreman, KJ, Fraser, M, Frostad, J, Kemmer, L, Kulikoff, XR, Kutz, M, Kyu, HH, Liu, P, Mikesell, J, Nguyen, G, Rao, PC, Silpakit, N, Sligar, A, Smith, A, Stanaway, JD, Arnlov, J, Abate, KH, Kiadaliri, AA, Alam, K, Alasfoor, D, Ali, R, Alizadeh-Navaei, R, Alraddadi, R, Altirkawi, KA, Alvis-Guzman, N, Anber, N, Ansari, H, Antonio, CAT, Anwari, P, Artaman, A, Asayesh, H, Asgedom, SW, Azzopardi, P, Bacha, U, Barac, A, Barker-Collo, SL, Bedi, N, Beghi, E, Bennett, DA, Bhutta, ZA, Bisanzio, D, Castaneda-Orjuela, CA, Estanislao Castro, R, Danawi, H, Deribe, K, Deribew, A, Jarlais, DCD, deVeber, GA, Dey, S, Dharmaratne, SD, Djalalinia, S, Huyen, PD, Esteghamati, A, Farvid, MS, Fereshtehnejad, S-M, Fischer, F, Gebrehiwot, TT, Giussani, G, Gona, PN, Hafezi-Nejad, N, Hamadeh, RR, Hamidi, S, Hoy, DG, Hu, G, John, D, Jonas, JB, Karimi, SM, Kasaeian, A, Khader, YS, Khan, EA, Khan, G, Kim, D, Kim, YJ, Kinfu, Y, Larson, HJ, Latif, AA, Leasher, JL, Lunevicius, R, Abd El Razek, HM, Abd El Razek, MM, Majeed, A, Malekzadeh, R, Memish, ZA, Mendoza, W, Mezgebe, HB, Miller, TR, Monasta, L, Quyen, LN, Obermeyer, CM, Ortiz, A, Papachristou, C, Park, E-K, Pereira, CC, Petzold, M, Pereira, DM, Phillips, MR, Pourmalek, F, Qorbani, M, Rafay, A, Rahimi-Movaghar, V, Rai, RK, Rana, SM, Rawaf, DL, Rawaf, S, Renzaho, AMN, Rezaei, S, Rezai, MS, Ronfani, L, Roshandel, G, Ruhago, GM, Safdarian, M, Safiri, S, Sahraian, MA, Salamati, P, Samy, AM, Sanabria, JR, Sartorius, B, Schwebel, DC, Seedat, S, Sepanlou, SG, Setegn, T, Shaheen, A, Shaikh, MA, Shamsizadeh, M, Shiri, R, Skirbekk, V, Sobaih, BHA, Sreeramareddy, CT, Stathopoulou, V, Abdulkader, RS, Tehrani-Banihashemi, A, Temsah, M-H, Thakur, AJS, Thomson, AJ, Tran, BX, Truelsen, T, Ukwaja, KN, Uthman, OA, Vasankari, T, Vlassov, VV, Weiderpass, E, Weintraub, RG, Werdecker, A, Yaghoubi, M, Yaseri, M, Yonemoto, N, Younis, MZ, Yu, C, Jumaan, AO, Vos, T, Hay, SI, Naghavi, M, Wang, H, and Murray, CJL
Abstract: OBJECTIVES: Although substantial reductions in under-5 mortality have been observed during the past 35 years, progress in the Eastern Mediterranean Region (EMR) has been uneven. This paper provides an overview of child mortality and morbidity in the EMR based on the Global Burden of Disease (GBD) study. METHODS: We used GBD 2015 study results to explore under-5 mortality and morbidity in EMR countries. RESULTS: In 2015, 755,844 (95% uncertainty interval (UI) 712,064-801,565) children under 5 died in the EMR. In the early neonatal category, deaths in the EMR decreased by 22.4%, compared to 42.4% globally. The rate of years of life lost per 100,000 population under 5 decreased 54.38% from 177,537 (173,812-181,463) in 1990 to 80,985 (76,308-85,876) in 2015; the rate of years lived with disability decreased by 0.57% in the EMR compared to 9.97% globally. CONCLUSIONS: Our findings call for accelerated action to decrease child morbidity and mortality in the EMR. Governments and organizations should coordinate efforts to address this burden. Political commitment is needed to ensure that child health receives the resources needed to end preventable deaths.
Published: 2018

26. Diabetes mellitus and chronic kidney disease in the Eastern Mediterranean Region: findings from the Global Burden of Disease 2015 study

Author: Mokdad, AH, Moradi-Lakeh, M, El Bcheraoui, C, Khalil, I, Charara, R, Afshin, A, Wang, H, Collison, M, Krohn, KJ, Chew, A, Daoud, F, Blosser, CD, Cornaby, L, Foreman, KJ, Kassebaum, NJ, Kemmer, L, Kutz, M, Liu, P, Zipkin, B, Arnlov, J, Abate, KH, Ahmadi, A, Ahmadieh, H, Ahmed, MB, Al-Aly, Z, Alam, K, Alasfoor, D, Ali, R, Alizadeh-Navaei, R, Alkaabi, JM, Alkerwi, A, Al-Raddadi, R, Altirkawi, KA, Alvis-Guzman, N, Amini, E, Anber, N, Anwari, P, Asgedom, SW, Atey, TM, Avila-Burgos, L, Awasthi, A, Azzopardi, P, Baernighausen, T, Bacha, U, Barac, A, Bazargan-Hejazi, S, Drew, CR, Geffen, D, Bedi, N, Berhe, DF, Beyene, AS, Bhutta, ZA, Bikbov, B, Birhanu, MM, Butt, ZA, Cahuana-Hurtado, L, Carpenter, DO, Carrero, JJ, Choi, J-YJJ, Danawi, H, Dharmaratne, SD, Ding, EL, Djalalinia, S, Doyle, KE, Ebrahimi, H, Endries, AY, Esteghamati, A, Farvid, MS, Fereshtehnejad, S-M, Feyissa, TR, Fischer, F, Gebrehiwot, TT, Gona, PN, Gopalani, SV, Gyawali, B, Hafezi-Nejad, N, Hamadeh, RR, Hamidi, S, Horino, M, Hsairi, M, Jakovljevic, MB, Jimenez-Corona, A, John, D, Jonas, JB, Kasaeian, A, Kengne, AP, Ketema, EB, Khader, YS, Khan, EA, Kim, D, Kim, YJ, Kinfu, Y, Kissimova-Skarbek, KA, Koyanagi, A, Larson, HJ, Larsson, A, Li, Y, Lotufo, PA, Lunevicius, R, Majeed, A, Malekzadeh, R, Malta, DC, Mazidi, M, Memish, ZA, Mendoza, W, Mengistie, MA, Mensah, GA, Mezgebe, HB, Miller, TR, Mohammed, MSK, Mohammed, S, Mueller, UO, Nagel, G, Cuong, TN, Quyen, LN, Vuong, MN, Noubiap, JJN, Ogbo, FA, Ortiz, A, Ota, E, Patel, T, Pearson-Stuttard, J, Perico, N, Petzold, M, Pishgar, F, Pourmalek, F, Qorbani, M, Rahimi-Movaghar, V, Rai, RK, Rana, SM, Rawaf, DL, Rawaf, S, Remuzzi, G, Renzaho, AMNN, Rezaei, S, Roshandel, G, Bacher, DR, Safdarian, M, Safi, S, Safiri, S, Sahraian, MA, Salamati, P, Samy, AM, Sanabria, JR, Dolores Sanchez-Nino, M, Milicevic, MMS, Sartorius, B, Sepanlou, SG, Shaikh, MA, Santos Silva, DA, Alves Silveira, DG, Sobaih, BHA, Abdulkader, RS, Tabares-Seisdedos, R, Tehrani-Banihashemi, A, Temsah, M-H, Topor-Madry, R, Tran, BX, Ukwaja, KN, Uthman, OA, van Boven, JFM, Wakayo, T, Werdecker, A, Workicho, A, Yaghoubi, M, Yano, Y, Yaseri, M, Yonemoto, N, Younis, MZ, Zhang, AL, Jumaan, AO, Vos, T, Naghavi, M, Hay, SI, Murray, CJL, Mokdad, AH, Moradi-Lakeh, M, El Bcheraoui, C, Khalil, I, Charara, R, Afshin, A, Wang, H, Collison, M, Krohn, KJ, Chew, A, Daoud, F, Blosser, CD, Cornaby, L, Foreman, KJ, Kassebaum, NJ, Kemmer, L, Kutz, M, Liu, P, Zipkin, B, Arnlov, J, Abate, KH, Ahmadi, A, Ahmadieh, H, Ahmed, MB, Al-Aly, Z, Alam, K, Alasfoor, D, Ali, R, Alizadeh-Navaei, R, Alkaabi, JM, Alkerwi, A, Al-Raddadi, R, Altirkawi, KA, Alvis-Guzman, N, Amini, E, Anber, N, Anwari, P, Asgedom, SW, Atey, TM, Avila-Burgos, L, Awasthi, A, Azzopardi, P, Baernighausen, T, Bacha, U, Barac, A, Bazargan-Hejazi, S, Drew, CR, Geffen, D, Bedi, N, Berhe, DF, Beyene, AS, Bhutta, ZA, Bikbov, B, Birhanu, MM, Butt, ZA, Cahuana-Hurtado, L, Carpenter, DO, Carrero, JJ, Choi, J-YJJ, Danawi, H, Dharmaratne, SD, Ding, EL, Djalalinia, S, Doyle, KE, Ebrahimi, H, Endries, AY, Esteghamati, A, Farvid, MS, Fereshtehnejad, S-M, Feyissa, TR, Fischer, F, Gebrehiwot, TT, Gona, PN, Gopalani, SV, Gyawali, B, Hafezi-Nejad, N, Hamadeh, RR, Hamidi, S, Horino, M, Hsairi, M, Jakovljevic, MB, Jimenez-Corona, A, John, D, Jonas, JB, Kasaeian, A, Kengne, AP, Ketema, EB, Khader, YS, Khan, EA, Kim, D, Kim, YJ, Kinfu, Y, Kissimova-Skarbek, KA, Koyanagi, A, Larson, HJ, Larsson, A, Li, Y, Lotufo, PA, Lunevicius, R, Majeed, A, Malekzadeh, R, Malta, DC, Mazidi, M, Memish, ZA, Mendoza, W, Mengistie, MA, Mensah, GA, Mezgebe, HB, Miller, TR, Mohammed, MSK, Mohammed, S, Mueller, UO, Nagel, G, Cuong, TN, Quyen, LN, Vuong, MN, Noubiap, JJN, Ogbo, FA, Ortiz, A, Ota, E, Patel, T, Pearson-Stuttard, J, Perico, N, Petzold, M, Pishgar, F, Pourmalek, F, Qorbani, M, Rahimi-Movaghar, V, Rai, RK, Rana, SM, Rawaf, DL, Rawaf, S, Remuzzi, G, Renzaho, AMNN, Rezaei, S, Roshandel, G, Bacher, DR, Safdarian, M, Safi, S, Safiri, S, Sahraian, MA, Salamati, P, Samy, AM, Sanabria, JR, Dolores Sanchez-Nino, M, Milicevic, MMS, Sartorius, B, Sepanlou, SG, Shaikh, MA, Santos Silva, DA, Alves Silveira, DG, Sobaih, BHA, Abdulkader, RS, Tabares-Seisdedos, R, Tehrani-Banihashemi, A, Temsah, M-H, Topor-Madry, R, Tran, BX, Ukwaja, KN, Uthman, OA, van Boven, JFM, Wakayo, T, Werdecker, A, Workicho, A, Yaghoubi, M, Yano, Y, Yaseri, M, Yonemoto, N, Younis, MZ, Zhang, AL, Jumaan, AO, Vos, T, Naghavi, M, Hay, SI, and Murray, CJL
Abstract: OBJECTIVES: We used findings from the Global Burden of Disease 2015 study to update our previous publication on the burden of diabetes and chronic kidney disease due to diabetes (CKD-DM) during 1990-2015. METHODS: We extracted GBD 2015 estimates for prevalence, mortality, and disability-adjusted life years (DALYs) of diabetes (including burden of low vision due to diabetes, neuropathy, and amputations and CKD-DM for 22 countries of the EMR from the GBD visualization tools. RESULTS: In 2015, 135,230 (95% UI 123,034-148,184) individuals died from diabetes and 16,470 (95% UI 13,977-18,961) from CKD-DM, 216 and 179% increases, respectively, compared to 1990. The total number of people with diabetes was 42.3 million (95% UI 38.6-46.4 million) in 2015. DALY rates of diabetes in 2015 were significantly higher than the expected rates based on Socio-demographic Index (SDI). CONCLUSIONS: Our study showed a large and increasing burden of diabetes in the region. There is an urgency in dealing with diabetes and its consequences, and these efforts should be at the forefront of health prevention and promotion.
Published: 2018

27. Burden of obesity in the Eastern Mediterranean Region: findings from the Global Burden of Disease 2015 study

Author: Mokdad, AH, El Bcheraoui, C, Afshin, A, Charara, R, Khalil, I, Moradi-Lakeh, M, Kassebaum, NJ, Collison, M, Daoud, F, Krohn, KJ, Chew, A, Biryukov, SH, Cornaby, L, Foreman, KJ, Kutz, M, Liu, P, Reitsma, M, Sur, P, Wang, H, Zipkin, B, Arnlov, J, Abbafati, C, Abdulle, AM, Abu-Rmeileh, NME, Ahmed, MB, Al-Aly, Z, Alam, K, Alizadeh-Navaei, R, Alkerwi, A, Altirkawi, KA, Alvis-Guzman, N, Baune, BT, Bedi, N, Bennett, DA, Beyene, AS, Bhutta, ZA, Birhanu, MM, Danawi, H, Fereshtehnejad, S-M, Fischer, F, Gebrehiwot, TT, Gill, PS, Gona, PN, Gupta, V, Habtewold, TD, Hamadeh, RR, Hamidi, S, Hareri, HA, Horino, M, Hsairi, M, Javanbakht, M, John, D, Jonas, JB, Joshua, V, Kasaeian, A, Ketema, EB, Khader, YS, Khan, EA, Khubchandani, J, Kim, D, Kim, YJ, Kinfu, Y, Kokubo, Y, Larson, HJ, Lee, PH, Lunevicius, R, Abd El Razek, HM, Abd El Razek, MM, Malekzadeh, R, Mate, KK, Memish, ZA, Mengistie, MA, Mensah, GA, Ogbo, FA, Pourmalek, F, Rafay, A, Qorbani, M, Rahimi-Movaghar, V, Rana, SM, Rawaf, S, Renzaho, AMN, Rezaei, S, Rezai, MS, Safdarian, M, Sahraian, MA, Salamati, P, Samy, AM, Sanabria, JR, Milicevic, MMS, Sartorius, B, Sepanlou, SG, Shaikh, MA, Shiri, R, Santos Silva, DA, Singh, JA, Terkawi, AS, Tiruye, TY, Ukwaja, KN, Vasankari, T, Vlassov, VV, Wakayo, T, Werdecker, A, Yonemoto, N, Younis, MZ, Zein, B, Jumaan, AO, Vos, T, Hay, SI, Naghavi, M, Murray, CJL, Mokdad, AH, El Bcheraoui, C, Afshin, A, Charara, R, Khalil, I, Moradi-Lakeh, M, Kassebaum, NJ, Collison, M, Daoud, F, Krohn, KJ, Chew, A, Biryukov, SH, Cornaby, L, Foreman, KJ, Kutz, M, Liu, P, Reitsma, M, Sur, P, Wang, H, Zipkin, B, Arnlov, J, Abbafati, C, Abdulle, AM, Abu-Rmeileh, NME, Ahmed, MB, Al-Aly, Z, Alam, K, Alizadeh-Navaei, R, Alkerwi, A, Altirkawi, KA, Alvis-Guzman, N, Baune, BT, Bedi, N, Bennett, DA, Beyene, AS, Bhutta, ZA, Birhanu, MM, Danawi, H, Fereshtehnejad, S-M, Fischer, F, Gebrehiwot, TT, Gill, PS, Gona, PN, Gupta, V, Habtewold, TD, Hamadeh, RR, Hamidi, S, Hareri, HA, Horino, M, Hsairi, M, Javanbakht, M, John, D, Jonas, JB, Joshua, V, Kasaeian, A, Ketema, EB, Khader, YS, Khan, EA, Khubchandani, J, Kim, D, Kim, YJ, Kinfu, Y, Kokubo, Y, Larson, HJ, Lee, PH, Lunevicius, R, Abd El Razek, HM, Abd El Razek, MM, Malekzadeh, R, Mate, KK, Memish, ZA, Mengistie, MA, Mensah, GA, Ogbo, FA, Pourmalek, F, Rafay, A, Qorbani, M, Rahimi-Movaghar, V, Rana, SM, Rawaf, S, Renzaho, AMN, Rezaei, S, Rezai, MS, Safdarian, M, Sahraian, MA, Salamati, P, Samy, AM, Sanabria, JR, Milicevic, MMS, Sartorius, B, Sepanlou, SG, Shaikh, MA, Shiri, R, Santos Silva, DA, Singh, JA, Terkawi, AS, Tiruye, TY, Ukwaja, KN, Vasankari, T, Vlassov, VV, Wakayo, T, Werdecker, A, Yonemoto, N, Younis, MZ, Zein, B, Jumaan, AO, Vos, T, Hay, SI, Naghavi, M, and Murray, CJL
Abstract: OBJECTIVES: We used the Global Burden of Disease (GBD) 2015 study results to explore the burden of high body mass index (BMI) in the Eastern Mediterranean Region (EMR). METHODS: We estimated the prevalence of overweight and obesity among children (2-19 years) and adults (≥20 years) in 1980 and 2015. The burden of disease related to high BMI was calculated using the GBD comparative risk assessment approach. RESULTS: The prevalence of obesity increased for adults from 15.1% (95% UI 13.4-16.9) in 1980 to 20.7% (95% UI 18.8-22.8) in 2015. It increased from 4.1% (95% UI 2.9-5.5) to 4.9% (95% UI 3.6-6.4) for the same period among children. In 2015, there were 417,115 deaths and 14,448,548 disability-adjusted life years (DALYs) attributable to high BMI in EMR, which constitute about 10 and 6.3% of total deaths and DALYs, respectively, for all ages. CONCLUSIONS: This is the first study to estimate trends in obesity burden for the EMR from 1980 to 2015. We call for EMR countries to invest more resources in prevention and health promotion efforts to reduce this burden.
Published: 2018

28. Burden of cardiovascular diseases in the Eastern Mediterranean Region, 1990-2015: findings from the Global Burden of Disease 2015 study

Author: Mokdad, AH, Tehrani-Banihashemi, A, Moradi-Lakeh, M, El Bcheraoui, C, Charara, R, Khalil, I, Afshin, A, Collison, M, Daoud, F, Krohn, KJ, Chew, A, Cornaby, L, Foreman, KJ, Frostad, J, Kassebaum, NJ, Kemmer, L, Kutz, M, Liu, P, Mirarefin, M, Nguyen, G, Wang, H, Zipkin, B, Abajobir, AA, Abouzeid, M, Abu-Rmeileh, NME, Kiadaliri, AA, Ahmed, MB, Aksut, B, Alam, K, Alasfoor, D, Ali, R, Alizadeh-Navaei, R, Al-Raddadi, R, Alsharif, U, Altirkawi, KA, Alvis-Guzman, N, Anber, N, Anwari, P, Arnlov, J, Asgedom, SW, Atey, TM, Awasthi, A, Baernighausen, T, Bacha, U, Barac, A, Barker-Collo, SL, Bedi, N, Bennett, DA, Berhe, DF, Biadgilign, S, Butt, ZA, Carapetis, JR, Estanislao Castro, R, Chitheer, AA, Davletov, K, Dharmaratne, SD, Djalalinia, S, Huyen, PD, Dubey, M, Ebrahimi, H, Eshrati, B, Esteghamati, A, Farvid, MS, Fereshtehnejad, S-M, Fischer, F, Gebrehiwot, SW, Gebrehiwot, TT, Gillum, RF, Gona, PN, Gupta, R, Hafezi-Nejad, N, Hamadeh, RR, Hamidi, S, Hsairi, M, Jee, SH, Jonas, JB, Karimkhani, C, Kasaeian, A, Khader, YS, Khan, EA, Kim, D, Lal, DK, Larson, HJ, Latif, AA, Linn, S, Lotufo, PA, Lunevicius, R, Abd El Razek, HM, Majeed, A, Malekzadeh, R, Malta, DC, Meier, T, Memiah, P, Memish, ZA, Mendoza, W, Mensah, GA, Meretoja, A, Miller, TR, Mirrakhimov, EM, Mohammed, S, Quyen, LN, Vuong, MN, Pearson-Stuttard, J, Pishgar, F, Pourmalek, F, Qorbani, M, Radfar, A, Rafay, A, Rahimi-Movaghar, V, Rai, RK, Rana, SM, Rawaf, DL, Rawaf, S, Renzaho, AMN, Rezaei, S, Roba, KT, Roshandel, G, Safdarian, M, Safi, S, Safiri, S, Sahraian, MA, Salamati, P, Samy, AM, Milicevic, MMS, Sartorius, B, Sepanlou, SG, Shaikh, MA, Santos Silva, DA, Singh, JA, Sobaih, BHA, Stroumpoulis, K, Abdulkader, RS, Szoeke, CEI, Temsah, M-H, Tran, BX, Ukwaja, KN, Uthman, OA, Vasankari, T, Vlassov, VV, Vollset, SE, Wakayo, T, Weintraub, RG, Wessly, PR, Wijeratne, T, Wolfe, CDA, Workicho, A, Yaghoubi, M, Yano, Y, Yaseri, M, Yonemoto, N, Younis, MZ, Yu, C, Zaki, MES, Jumaan, AO, Vos, T, Roth, GA, Hay, SI, Naghavi, M, Murray, CJL, Mokdad, AH, Tehrani-Banihashemi, A, Moradi-Lakeh, M, El Bcheraoui, C, Charara, R, Khalil, I, Afshin, A, Collison, M, Daoud, F, Krohn, KJ, Chew, A, Cornaby, L, Foreman, KJ, Frostad, J, Kassebaum, NJ, Kemmer, L, Kutz, M, Liu, P, Mirarefin, M, Nguyen, G, Wang, H, Zipkin, B, Abajobir, AA, Abouzeid, M, Abu-Rmeileh, NME, Kiadaliri, AA, Ahmed, MB, Aksut, B, Alam, K, Alasfoor, D, Ali, R, Alizadeh-Navaei, R, Al-Raddadi, R, Alsharif, U, Altirkawi, KA, Alvis-Guzman, N, Anber, N, Anwari, P, Arnlov, J, Asgedom, SW, Atey, TM, Awasthi, A, Baernighausen, T, Bacha, U, Barac, A, Barker-Collo, SL, Bedi, N, Bennett, DA, Berhe, DF, Biadgilign, S, Butt, ZA, Carapetis, JR, Estanislao Castro, R, Chitheer, AA, Davletov, K, Dharmaratne, SD, Djalalinia, S, Huyen, PD, Dubey, M, Ebrahimi, H, Eshrati, B, Esteghamati, A, Farvid, MS, Fereshtehnejad, S-M, Fischer, F, Gebrehiwot, SW, Gebrehiwot, TT, Gillum, RF, Gona, PN, Gupta, R, Hafezi-Nejad, N, Hamadeh, RR, Hamidi, S, Hsairi, M, Jee, SH, Jonas, JB, Karimkhani, C, Kasaeian, A, Khader, YS, Khan, EA, Kim, D, Lal, DK, Larson, HJ, Latif, AA, Linn, S, Lotufo, PA, Lunevicius, R, Abd El Razek, HM, Majeed, A, Malekzadeh, R, Malta, DC, Meier, T, Memiah, P, Memish, ZA, Mendoza, W, Mensah, GA, Meretoja, A, Miller, TR, Mirrakhimov, EM, Mohammed, S, Quyen, LN, Vuong, MN, Pearson-Stuttard, J, Pishgar, F, Pourmalek, F, Qorbani, M, Radfar, A, Rafay, A, Rahimi-Movaghar, V, Rai, RK, Rana, SM, Rawaf, DL, Rawaf, S, Renzaho, AMN, Rezaei, S, Roba, KT, Roshandel, G, Safdarian, M, Safi, S, Safiri, S, Sahraian, MA, Salamati, P, Samy, AM, Milicevic, MMS, Sartorius, B, Sepanlou, SG, Shaikh, MA, Santos Silva, DA, Singh, JA, Sobaih, BHA, Stroumpoulis, K, Abdulkader, RS, Szoeke, CEI, Temsah, M-H, Tran, BX, Ukwaja, KN, Uthman, OA, Vasankari, T, Vlassov, VV, Vollset, SE, Wakayo, T, Weintraub, RG, Wessly, PR, Wijeratne, T, Wolfe, CDA, Workicho, A, Yaghoubi, M, Yano, Y, Yaseri, M, Yonemoto, N, Younis, MZ, Yu, C, Zaki, MES, Jumaan, AO, Vos, T, Roth, GA, Hay, SI, Naghavi, M, and Murray, CJL
Abstract: OBJECTIVES: To report the burden of cardiovascular diseases (CVD) in the Eastern Mediterranean Region (EMR) during 1990-2015. METHODS: We used the 2015 Global Burden of Disease study for estimates of mortality and disability-adjusted life years (DALYs) of different CVD in 22 countries of EMR. RESULTS: A total of 1.4 million CVD deaths (95% UI: 1.3-1.5) occurred in 2015 in the EMR, with the highest number of deaths in Pakistan (465,116) and the lowest number of deaths in Qatar (723). The age-standardized DALY rate per 100,000 decreased from 10,080 in 1990 to 8606 in 2015 (14.6% decrease). Afghanistan had the highest age-standardized DALY rate of CVD in both 1990 and 2015. Kuwait and Qatar had the lowest age-standardized DALY rates of CVD in 1990 and 2015, respectively. High blood pressure, high total cholesterol, and high body mass index were the leading risk factors for CVD. CONCLUSIONS: The age-standardized DALY rates in the EMR are considerably higher than the global average. These findings call for a comprehensive approach to prevent and control the burden of CVD in the region.
Published: 2018

29. Burden of diarrhea in the Eastern Mediterranean Region, 1990-2015: Findings from the Global Burden of Disease 2015 study

Author: Mokdad, AH, Khalil, I, El Bcheraoui, C, Charara, R, Moradi-Lakeh, M, Afshin, A, Kassebaum, NJ, Collison, M, Chew, A, Krohn, KJ, Daoud, F, Colombara, D, Foreman, KJ, Godwin, WW, Kutz, M, Mirarefin, M, Rao, PC, Reiner, R, Troeger, C, Wang, H, Abraha, HN, Abu-Elyazeed, R, Abu-Raddad, LJ, Kiadaliri, AA, Ahmadi, A, Ahmed, MB, Alam, K, Alizadeh-Navaei, R, Al-Raddadi, R, Altirkawi, KA, Alvis-Guzman, N, Anber, N, Anwari, P, Atey, TM, Avokpaho, EFGA, Bacha, U, Bazargan-Hejazi, S, Geffen, D, Bedi, N, Bensenor, IM, Berhane, A, Bessong, PO, Beyene, AS, Bhutta, ZA, Buckle, GC, Butt, ZA, Danawi, H, Deribew, A, Djalalinia, S, Dubey, M, Endries, AY, Eshrati, B, Fereshtehnejad, S-M, Fischer, F, Gebrehiwot, TT, Gugnani, HC, Hamadeh, RR, Hamidi, S, Husseini, A, James, SL, Jonas, JB, Kasaeian, A, Khader, YS, Khan, EA, Khan, G, Khubchandani, J, Kissoon, N, Kopec, JA, Koyanagi, A, Defo, BK, Larson, HJ, Latif, AA, Lunevicius, R, Abd El Razek, HM, Abd El Razek, MM, Majdzadeh, R, Majeed, A, Malekzadeh, R, Memiah, P, Memish, ZA, Mendoza, W, Mengistu, DT, Mohammed, S, Murthy, S, Ngunjiri, JW, Ogbo, FA, Pourmalek, F, Qorbani, M, Radfar, A, Rafay, A, Rahimi-Movaghar, V, Rai, RK, Ram, U, Rawaf, DL, Rawaf, S, Renzaho, AMN, Rezaei, S, Roshandel, G, Safdarian, M, Sahraian, MA, Salamati, P, Samy, AM, Sanabria, JR, Sartorius, B, Sepanlou, SG, Shaikh, MA, Shigematsu, M, Sobaih, BHA, Sreeramareddy, CT, Sykes, BL, Tehrani-Banihashemi, A, Temsah, M-H, Terkawi, AS, Tiruye, TY, Topor-Madry, R, Ukwaja, KN, Vollset, SE, Wakayo, T, Werdecker, A, Wiysonge, CS, Workicho, A, Yaghoubi, M, Yaseri, M, Yenesew, M, Yonemoto, N, Younis, MZ, Zaki, MES, Zodpey, S, Zein, B, Jumaan, AO, Vos, T, Hay, SI, Naghavi, M, Murray, CJL, Mokdad, AH, Khalil, I, El Bcheraoui, C, Charara, R, Moradi-Lakeh, M, Afshin, A, Kassebaum, NJ, Collison, M, Chew, A, Krohn, KJ, Daoud, F, Colombara, D, Foreman, KJ, Godwin, WW, Kutz, M, Mirarefin, M, Rao, PC, Reiner, R, Troeger, C, Wang, H, Abraha, HN, Abu-Elyazeed, R, Abu-Raddad, LJ, Kiadaliri, AA, Ahmadi, A, Ahmed, MB, Alam, K, Alizadeh-Navaei, R, Al-Raddadi, R, Altirkawi, KA, Alvis-Guzman, N, Anber, N, Anwari, P, Atey, TM, Avokpaho, EFGA, Bacha, U, Bazargan-Hejazi, S, Geffen, D, Bedi, N, Bensenor, IM, Berhane, A, Bessong, PO, Beyene, AS, Bhutta, ZA, Buckle, GC, Butt, ZA, Danawi, H, Deribew, A, Djalalinia, S, Dubey, M, Endries, AY, Eshrati, B, Fereshtehnejad, S-M, Fischer, F, Gebrehiwot, TT, Gugnani, HC, Hamadeh, RR, Hamidi, S, Husseini, A, James, SL, Jonas, JB, Kasaeian, A, Khader, YS, Khan, EA, Khan, G, Khubchandani, J, Kissoon, N, Kopec, JA, Koyanagi, A, Defo, BK, Larson, HJ, Latif, AA, Lunevicius, R, Abd El Razek, HM, Abd El Razek, MM, Majdzadeh, R, Majeed, A, Malekzadeh, R, Memiah, P, Memish, ZA, Mendoza, W, Mengistu, DT, Mohammed, S, Murthy, S, Ngunjiri, JW, Ogbo, FA, Pourmalek, F, Qorbani, M, Radfar, A, Rafay, A, Rahimi-Movaghar, V, Rai, RK, Ram, U, Rawaf, DL, Rawaf, S, Renzaho, AMN, Rezaei, S, Roshandel, G, Safdarian, M, Sahraian, MA, Salamati, P, Samy, AM, Sanabria, JR, Sartorius, B, Sepanlou, SG, Shaikh, MA, Shigematsu, M, Sobaih, BHA, Sreeramareddy, CT, Sykes, BL, Tehrani-Banihashemi, A, Temsah, M-H, Terkawi, AS, Tiruye, TY, Topor-Madry, R, Ukwaja, KN, Vollset, SE, Wakayo, T, Werdecker, A, Wiysonge, CS, Workicho, A, Yaghoubi, M, Yaseri, M, Yenesew, M, Yonemoto, N, Younis, MZ, Zaki, MES, Zodpey, S, Zein, B, Jumaan, AO, Vos, T, Hay, SI, Naghavi, M, and Murray, CJL
Abstract: OBJECTIVES: Diarrheal diseases (DD) are an important cause of disease burden, especially in children in low-income settings. DD can also impact children's potential livelihood through growth faltering, cognitive impairment, and other sequelae. METHODS: As part of the Global Burden of Disease study, we estimated DD burden, and the burden attributable to specific risk factors and etiologies, in the Eastern Mediterranean Region (EMR) between 1990 and 2015. We calculated disability-adjusted life-years (DALYs)-the sum of years of life lost and years lived with disability-for both sexes and all ages. RESULTS: We estimate that over 103,692 diarrhea deaths occurred in the EMR in 2015 (95% uncertainty interval: 87,018-124,692), and the mortality rate was 16.0 deaths per 100,000 persons (95% UI: 13.4-19.2). The majority of these deaths occurred in children under 5 (63.3%) (65,670 deaths, 95% UI: 53,640-79,486). DALYs per 100,000 ranged from 304 (95% UI 228-400) in Kuwait to 38,900 (95% UI 25,900-54,300) in Somalia. CONCLUSIONS: Our findings will guide evidence-based health policy decisions for interventions to achieve the ultimate goal of reducing the DD burden.
Published: 2018

30. Child and Adolescent Health From 1990 to 2015: Findings From the Global Burden of Diseases, Injuries, and Risk Factors 2015 Study

Author: Global Burden of Disease Child and Adolescent Health Collaboration, Kassebaum N, Kyu HH, Zoeckler L, Olsen HE, Thomas K, Pinho C, Bhutta ZA, Dandona L, Ferrari A, Ghiwot TT, Hay SI, Kinfu Y, Liang X, Lopez A, Malta DC, Mokdad AH, Naghavi M, Patton GC, Salomon J, Sartorius B, Topor-Madry R, Vollset SE, Werdecker A, Whiteford HA, Abate KH, Abbas K, Damtew SA, Ahmed MB, Akseer N, Al-Raddadi R, Alemayohu MA, Altirkawi K, Abajobir AA, Amare AT, Antonio CAT, Arnlov J, Artaman A, Asayesh H, Avokpaho EFGA, Awasthi A, Ayala Quintanilla BP, Bacha U, Betsu BD, Barac A, Bärnighausen TW, Baye E, Bedi N, Bensenor IM, Berhane A, Bernabe E, Bernal OA, Beyene AS, Biadgilign S, Bikbov B, Boyce CA, Brazinova A, Hailu GB, Carter A, Castañeda-Orjuela CA, Catalá-López F, Charlson FJ, Chitheer AA, Choi JJ, Ciobanu LG, Crump J, Dandona R, Dellavalle RP, Deribew A, deVeber G, Dicker D, Ding EL, Dubey M, Endries AY, Erskine HE, Faraon EJA, Faro A, Farzadfar F, Fernandes JC, Fijabi DO, Fitzmaurice C, Fleming TD, Flor LS, Foreman KJ, Franklin RC, Fraser MS, Frostad JJ, Fullman N, Gebregergs GB, Gebru AA, Geleijnse JM, Gibney KB, Gidey Yihdego M, Ginawi IAM, Gishu MD, Gizachew TA, Glaser E, Gold AL, Goldberg E, Gona P, Goto A, Gugnani HC, Jiang G, Gupta R, Tesfay FH, Hankey GJ, Havmoeller R, Hijar M, Horino M, Hosgood HD, Hu G, Jacobsen KH, Jakovljevic MB, Jayaraman SP, Jha V, Jibat T, Johnson CO, Jonas J, Kasaeian A, Kawakami N, Keiyoro PN, Khalil I, Khang YH, Khubchandani J, Ahmad Kiadaliri AA, Kieling C, Kim D, Kissoon N, Knibbs LD, Koyanagi A, Krohn KJ, Kuate Defo B, Kucuk Bicer B, Kulikoff R, Kumar GA, Lal DK, Lam HY, Larson HJ, Larsson A, Laryea DO, Leung J, Lim SS, Lo LT, Lo WD, Looker KJ, Lotufo PA, Magdy Abd El Razek H, Malekzadeh R, Markos Shifti D, Mazidi M, Meaney PA, Meles KG, Memiah P, Mendoza W, Abera Mengistie M, Mengistu GW, Mensah GA, Miller TR, Mock C, Mohammadi A, Mohammed S, Monasta L, Mueller U, Nagata C, Naheed A, Nguyen G, Nguyen QL, Nsoesie E, Oh IH, Okoro A, Olusanya JO, Olusanya BO, Ortiz A, Paudel D, Pereira DM, Perico N, Petzold M, Phillips MR, Polanczyk GV, Pourmalek F, Qorbani M, Rafay A, Rahimi-Movaghar V, Rahman M, Rai RK, Ram U, Rankin Z, Remuzzi G, Renzaho AMN, Roba HS, Rojas-Rueda D, Ronfani L, Sagar R, Sanabria JR, Kedir Mohammed MS, Santos IS, Satpathy M, Sawhney M, Schöttker B, Schwebel DC, Scott JG, Sepanlou SG, Shaheen A, Shaikh MA, She J, Shiri R, Shiue I, Sigfusdottir ID, Singh J, Silpakit N, Smith A, Sreeramareddy C, Stanaway JD, Stein DJ, Steiner C, Sufiyan MB, Swaminathan S, Tabarés-Seisdedos R, Tabb KM, Tadese F, Tavakkoli M, Taye B, Teeple S, Tegegne TK, Temam Shifa G, Terkawi AS, Thomas B, Thomson AJ, Tobe-Gai R, Tonelli M, Tran BX, Troeger C, Ukwaja KN, Uthman O, Vasankari T, Venketasubramanian N, Vlassov VV, Weiderpass E, Weintraub R, Gebrehiwot SW, Westerman R, Williams HC, Wolfe CDA, Woodbrook R, Yano Y, Yonemoto N, Yoon SJ, Younis MZ, Yu C, Zaki MES, Zegeye EA, Zuhlke LJ, Murray CJL, and Vos T
Subjects: Male, Adolescent, G300, L500, Adolescent Health, Age Factors, Child Health, Correction, Global Health, Disabled Children, Global Burden of Disease, Pregnancy Complications, Sex Factors, Pregnancy, Risk Factors, Cause of Death, Child Mortality, Humans, Wounds and Injuries, Female, Child
Abstract: IMPORTANCE: Comprehensive and timely monitoring of disease burden in all age groups, including children and adolescents, is essential for improving population health. OBJECTIVE: To quantify and describe levels and trends of mortality and nonfatal health outcomes among children and adolescents from 1990 to 2015 to provide a framework for policy discussion. EVIDENCE REVIEW: Cause-specific mortality and nonfatal health outcomes were analyzed for 195 countries and territories by age group, sex, and year from 1990 to 2015 using standardized approaches for data processing and statistical modeling, with subsequent analysis of the findings to describe levels and trends across geography and time among children and adolescents 19 years or younger. A composite indicator of income, education, and fertility was developed (Socio-demographic Index [SDI]) for each geographic unit and year, which evaluates the historical association between SDI and health loss. FINDINGS: Global child and adolescent mortality decreased from 14.18 million (95% uncertainty interval [UI], 14.09 million to 14.28 million) deaths in 1990 to 7.26 million (95% UI, 7.14 million to 7.39 million) deaths in 2015, but progress has been unevenly distributed. Countries with a lower SDI had a larger proportion of mortality burden (75%) in 2015 than was the case in 1990 (61%). Most deaths in 2015 occurred in South Asia and sub-Saharan Africa. Global trends were driven by reductions in mortality owing to infectious, nutritional, and neonatal disorders, which in the aggregate led to a relative increase in the importance of noncommunicable diseases and injuries in explaining global disease burden. The absolute burden of disability in children and adolescents increased 4.3% (95% UI, 3.1%-5.6%) from 1990 to 2015, with much of the increase owing to population growth and improved survival for children and adolescents to older ages. Other than infectious conditions, many top causes of disability are associated with long-term sequelae of conditions present at birth (eg, neonatal disorders, congenital birth defects, and hemoglobinopathies) and complications of a variety of infections and nutritional deficiencies. Anemia, developmental intellectual disability, hearing loss, epilepsy, and vision loss are important contributors to childhood disability that can arise from multiple causes. Maternal and reproductive health remains a key cause of disease burden in adolescent females, especially in lower-SDI countries. In low-SDI countries, mortality is the primary driver of health loss for children and adolescents, whereas disability predominates in higher-SDI locations; the specific pattern of epidemiological transition varies across diseases and injuries. CONCLUSIONS AND RELEVANCE: Consistent international attention and investment have led to sustained improvements in causes of health loss among children and adolescents in many countries, although progress has been uneven. The persistence of infectious diseases in some countries, coupled with ongoing epidemiologic transition to injuries and noncommunicable diseases, require all countries to carefully evaluate and implement appropriate strategies to maximize the health of their children and adolescents and for the international community to carefully consider which elements of child and adolescent health should be monitored.
Published: 2017

31. Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-years for 32 Cancer Groups, 1990 to 2015: A Systematic Analysis for the Global Burden of Disease Study

Author: Global Burden of Disease Cancer Collaboration, Fitzmaurice C, Allen C, Barber RM, Barregard L, Bhutta ZA, Brenner H, Dicker DJ, Chimed-Orchir O, Dandona R, Dandona L, Fleming T, Forouzanfar MH, Hancock J, Hay RJ, Hunter-Merrill R, Huynh C, Hosgood HD, Johnson CO, Jonas JB, Khubchandani J, Kumar GA, Kutz M, Lan Q, Larson HJ, Liang X, Lim SS, Lopez AD, MacIntyre MF, Marczak L, Marquez N, Mokdad AH, Pinho C, Pourmalek F, Salomon JA, Sanabria JR, Sandar L, Sartorius B, Schwartz SM, Shackelford KA, Shibuya K, Stanaway J, Steiner C, Sun J, Takahashi K, Vollset SE, Vos T, Wagner JA, Wang H, Westerman R, Zeeb H, Zoeckler L, Abd-Allah F, Ahmed MB, Alabed S, Alam NK, Aldhahri SF, Alem G, Alemayohu MA, Ali R, Al-Raddadi R, Amare A, Amoako Y, Artaman A, Asayesh H, Atnafu N, Awasthi A, Saleem HB, Barac A, Bedi N, Bensenor I, Berhane A, Bernabé E, Betsu B, Binagwaho A, Boneya D, Campos-Nonato I, Castañeda-Orjuela C, Catalá-López F, Chiang P, Chibueze C, Chitheer A, Choi JY, Cowie B, Damtew S, das Neves J, Dey S, Dharmaratne S, Dhillon P, Ding E, Driscoll T, Ekwueme D, Endries AY, Farvid M, Farzadfar F, Fernandes J, Fischer F, G/Hiwot TT, Gebru A, Gopalani S, Hailu A, Horino M, Horita N, Husseini A, Huybrechts I, Inoue M, Islami F, Jakovljevic M, James S, Javanbakht M, Jee SH, Kasaeian A, Kedir MS, Khader YS, Khang YH, Kim D, Leigh J, Linn S, Lunevicius R, El Razek HMA, Malekzadeh R, Malta DC, Marcenes W, Markos D, Melaku YA, Meles KG, Mendoza W, Mengiste DT, Meretoja TJ, Miller TR, Mohammad KA, Mohammadi A, Mohammed S, Moradi-Lakeh M, Nagel G, Nand D, Le Nguyen Q, Nolte S, Ogbo FA, Oladimeji KE, Oren E, Pa M, Park EK, Pereira DM, Plass D, Qorbani M, Radfar A, Rafay A, Rahman M, Rana SM, Søreide K, Satpathy M, Sawhney M, Sepanlou SG, Shaikh MA, She J, Shiue I, Shore HR, Shrime MG, So S, Soneji S, Stathopoulou V, Stroumpoulis K, Sufiyan MB, Sykes BL, Tabarés-Seisdedos R, Tadese F, Tedla BA, Tessema GA, Thakur JS, Tran BX, Ukwaja KN, Uzochukwu BSC, Vlassov VV, Weiderpass E, Wubshet Terefe M, Yebyo HG, Yimam HH, Yonemoto N, Younis MZ, Yu C, Zaidi Z, Zaki MES, Zenebe ZM, Murray CJL, and Naghavi M
Published: 2017

32. Global, regional, and national burden of neurological disorders during 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015

Author: Feigin, VL, Abajobir, AA, Abate, KH, Abd-Allah, F, Abdulle, AM, Abera, SF, Abyu, GY, Ahmed, MB, Aichour, AN, Aichour, I, Aichour, MTE, Akinyemi, RO, Alabed, S, Al-Raddadi, R, Alvis-Guzman, N, Amare, AT, Ansari, H, Anwari, P, Arnlov, J, Asayesh, H, Asgedom, SW, Atey, TM, Avila-Burgos, L, Avokpaho, EFGA, Azarpazhooh, MR, Barac, A, Barboza, M, Barker-Collo, SL, Baernighausen, T, Bedi, N, Beghi, E, Bennett, DA, Bensenor, IM, Berhane, A, Betsu, BD, Bhaumik, S, Birlik, SM, Biryukov, S, Boneya, DJ, Bulto, LN, Carabin, H, Casey, D, Castaneda-Orjuela, CA, Catala-Lopez, F, Chen, H, Chitheer, AA, Chowdhury, R, Christensen, H, Dandona, L, Dandona, R, deVeber, GA, Dharmaratne, SD, Do, HP, Dokova, K, Dorsey, ER, Ellenbogen, RG, Eskandarieh, S, Farvid, MS, Fereshtehnejad, S-M, Fischer, F, Foreman, KJ, Geleijnse, JM, Gillum, RF, Giussani, G, Goldberg, EM, Gona, PN, Goulart, AC, Gugnani, HC, Gupta, R, Hachinski, V, Hamadeh, RR, Hambisa, M, Hankey, GJ, Hareri, HA, Havmoeller, R, Hay, SI, Heydarpour, P, Hotez, PJ, Jakovljevic, MMB, Javanbakht, M, Jeemon, P, Jonas, JB, Kalkonde, Y, Kandel, A, Karch, A, Kasaeian, A, Kastor, A, Keiyoro, PN, Khader, YS, Khalil, IA, Khan, EA, Khang, Y-H, Khoja, AT, Khubchandani, J, Kulkarni, C, Kim, D, Kim, YJ, Kivimaki, M, Kokubo, Y, Kosen, S, Kravchenko, M, Krishnamurthi, RV, Defo, BK, Kumar, GA, Kumar, R, Kyu, HH, Larsson, A, Lavados, PM, Li, Y, Liang, X, Liben, ML, Lo, WD, Logroscino, G, Lotufo, PA, Loy, CT, Mackay, MT, Abd El Razek, HM, Abd El Razek, MM, Majeed, A, Malekzadeh, R, Manhertz, T, Mantovani, LG, Massano, J, Mazidi, M, McAlinden, C, Mehata, S, Mehndiratta, MM, Memish, ZA, Mendoza, W, Mengistie, MA, Mensah, GA, Meretoja, A, Mezgebe, HB, Miller, TR, Mishra, SR, Ibrahim, NM, Mohammadi, A, Mohammed, KE, Mohammed, S, Mokdad, AH, Moradi-Lakeh, M, Velasquez, IM, Musa, KI, Naghavi, M, Ngunjiri, JW, Nguyen, CT, Nguyen, G, Nguyen, QL, Nguyen, TH, Nichols, E, Ningrum, DN, Nong, VM, Norrving, B, Noubiap, JJN, Ogbo, FA, Owolabi, MO, Pandian, JD, Parmar, PG, Pereira, DM, Petzold, M, Phillips, MR, Piradov, MA, Poulton, RG, Pourmalek, F, Qorbani, M, Rafay, A, Rahman, M, Rahman, MH, Rai, RK, Rajsic, S, Ranta, A, Rawaf, S, Renzaho, AMN, Rezai, MS, Roth, GA, Roshandel, G, Rubagotti, E, Sachdev, P, Safiri, S, Sahathevan, R, Sahraian, MA, Samy, AM, Santalucia, P, Santos, IS, Sartorius, B, Satpathy, M, Sawhney, M, Saylan, MI, Sepanlou, SG, Shaikh, MA, Shakir, R, Shamsizadeh, M, Sheth, KN, Shigematsu, M, Shoman, H, Silva, DA, Smith, M, Sobngwi, E, Sposato, LA, Stanaway, JD, Stein, DJ, Steiner, TJ, Stovner, LJ, Abdulkader, RS, Szoeke, CEI, Tabares-Seisdedos, R, Tanne, D, Theadom, AM, Thrift, AG, Tirschwell, DL, Topor-Madry, R, Tran, BX, Truelsen, T, Tuem, KB, Ukwaja, KN, Uthman, OA, Varakin, YY, Vasankari, T, Venketasubramanian, N, Vlassov, VV, Wadilo, F, Wakayo, T, Wallin, MT, Weiderpass, E, Westerman, R, Wijeratne, T, Wiysonge, CS, Woldu, MA, Wolfe, CDA, Xavier, D, Xu, G, Yano, Y, Yimam, HH, Yonemoto, N, Yu, C, Zaidi, Z, Zaki, MES, Zunt, JR, Murray, CJL, Vos, T, Disorders, GBDN, Feigin, V, Abajobir, A, Abate, K, Abd-Allah, F, Abdulle, A, Abera, S, Abyu, G, Ahmed, M, Aichour, A, Aichour, I, Aichour, M, Akinyemi, R, Alabed, S, Al-Raddadi, R, Alvis-Guzman, N, Amare, A, Ansari, H, Anwari, P, Ärnlöv, J, Asayesh, H, Asgedom, S, Atey, T, Avila-Burgos, L, Frinel, E, Avokpaho, G, Barac, A, Barboza, M, Barker-Collo, S, Bärnighausen, T, Bedi, N, Beghi, E, Bennett, D, Bensenor, I, Berhane, A, Betsu, B, Bhaumik, S, Birlik, S, Biryukov, S, Boneya, D, Bulto, L, Carabin, H, Casey, D, Castañeda-Orjuela, C, Catalá-López, F, Chen, H, Chitheer, A, Chowdhury, R, Christensen, H, Dandona, L, Dandona, R, Veber, G, Dharmaratne, S, Do, H, Dokova, K, Dorsey, E, Ellenbogen, R, Eskandarieh, S, Farvid, M, Fereshtehnejad, S, Fischer, F, Foreman, K, Geleijnse, J, Gillum, R, Giussani, G, Gona, P, Goulart, A, Gugnani, H, Gupta, R, Hamadeh, R, Hambisa, M, Hankey, G, Hareri, H, Havmoeller, R, Hay, S, Heydarpour, P, Hotez, P, Jakovljevic, M, Javanbakht, M, Jeemon, P, Jonas, J, Kalkonde, Y, Kandel, A, Karch, A, Kasaeian, A, Kastor, A, Keiyoro, P, Khader, Y, Khalil, I, Khan, E, Khang, Y, Tawfih, A, Khoja, A, Khubchandani, J, Kim, D, Kim, Y, Kivimaki, M, Kokubo, Y, Kosen, S, Kravchenko, M, Krishnamurthi, R, Defo, B, Kumar, G, Kumar, R, Kyu, H, Larsson, A, Lavados, P, Li, Y, Liang, X, Liben, M, Lo, W, Logroscino, G, Lotufo, P, Loy, C, Mackay, M, El Razek, H, El Razek, M, Majeed, A, Malekzadeh, R, Manhertz, T, Mantovani, L, Massano, J, Mazidi, M, Mcalinden, C, Mehata, S, Mehndiratta, M, Memish, Z, Mendoza, W, Mengistie, M, Mensah, G, Meretoja, A, Mezgebe, H, Miller, T, Mishra, S, Ibrahim, N, Mohammadi, A, Mohammed, K, Mohammed, S, Mokdad, A, Moradi-Lakeh, M, Velasquez, I, Musa, K, Naghavi, M, Ngunjiri, J, Nguyen, C, Nguyen, G, Le Nguyen, Q, Nguyen, T, Nichols, E, Ningrum, D, Nong, V, Norrving, B, Noubiap, J, Ogbo, F, Owolabi, M, Pandian, J, Petzold, M, Phillips, M, Piradov, M, Poulton, R, Pourmalek, F, Qorbani, M, Rafay, A, Rahman, M, Rai, R, Rajsic, S, Ranta, A, Rawaf, S, Renzaho, A, Rezai, M, Roshandel, G, Rubagotti, E, Sachdev, P, Safiri, S, Sahathevan, R, Sahraian, M, Samy, A, Santalucia, P, Santos, I, Sartorius, B, Satpathy, M, Sawhney, M, Saylan, M, Sepanlou, S, Shaikh, M, Shakir, R, Shamsizadeh, M, Sheth, K, Shigematsu, M, Shoman, H, Silva, D, Smith, M, Sobngwi, E, Sposato, L, Stein, D, Steiner, T, Stovner, L, Abdulkader, R, EI Szoeke, C, Tabarés-Seisdedos, R, Tanne, D, Theadom, A, Thrift, A, Tirschwell, D, Topor-Madry, R, Tran, B, Truelsen, T, Tuem, K, Ukwaja, K, Uthman, O, Varakin, Y, Vasankari, T, Venketasubramanian, N, Vlassov, V, Wadilo, F, Wakayo, T, Wallin, M, Weiderpass, E, Westerman, R, Wijeratne, T, Wiysonge, C, Woldu, M, Wolfe, C, Xavier, D, Xu, G, Yano, Y, Yimam, H, Yonemoto, N, Yu, C, Zaidi, Z, El Sayed Zaki, M, Zunt, J, Murray, C, and Vos, T
Subjects: Cost of Illness, Nutrition and Disease, GBD, Voeding en Ziekte, Humans, Life Science, Quality-Adjusted Life Years, Nervous System Diseases, Global Health, Article, Global Burden of Disease, VLAG
Abstract: Background Comparable data on the global and country-specific burden of neurological disorders and their trends are\ud crucial for health-care planning and resource allocation. The Global Burden of Diseases, Injuries, and Risk Factors\ud (GBD) Study provides such information but does not routinely aggregate results that are of interest to clinicians\ud specialising in neurological conditions. In this systematic analysis, we quantified the global disease burden due to\ud neurological disorders in 2015 and its relationship with country development level.\ud \ud Methods We estimated global and country-specific prevalence, mortality, disability-adjusted life-years (DALYs), years\ud of life lost (YLLs), and years lived with disability (YLDs) for various neurological disorders that in the GBD classification\ud have been previously spread across multiple disease groupings. The more inclusive grouping of neurological\ud disorders included stroke, meningitis, encephalitis, tetanus, Alzheimer’s disease and other dementias, Parkinson’s\ud disease, epilepsy, multiple sclerosis, motor neuron disease, migraine, tension-type headache, medication overuse\ud headache, brain and nervous system cancers, and a residual category of other neurological disorders. We also analysed\ud results based on the Socio-demographic Index (SDI), a compound measure of income per capita, education, and\ud fertility, to identify patterns associated with development and how countries fare against expected outcomes relative\ud to their level of development.\ud \ud Findings Neurological disorders ranked as the leading cause group of DALYs in 2015 (250·7 [95% uncertainty interval\ud (UI) 229·1 to 274·7] million, comprising 10·2% of global DALYs) and the second-leading cause group of deaths (9·4\ud [9·1 to 9·7] million], comprising 16·8% of global deaths). The most prevalent neurological disorders were tensiontype\ud headache (1505·9 [UI 1337·3 to 1681·6 million cases]), migraine (958·8 [872·1 to 1055·6] million), medication\ud overuse headache (58·5 [50·8 to 67·4 million]), and Alzheimer’s disease and other dementias (46·0\ud [40·2 to 52·7 million]). Between 1990 and 2015, the number of deaths from neurological disorders increased by\ud 36·7%, and the number of DALYs by 7·4%. These increases occurred despite decreases in age-standardised rates of\ud death and DALYs of 26·1% and 29·7%, respectively; stroke and communicable neurological disorders were\ud responsible for most of these decreases. Communicable neurological disorders were the largest cause of DALYs in\ud countries with low SDI. Stroke rates were highest at middle levels of SDI and lowest at the highest SDI. Most of the\ud changes in DALY rates of neurological disorders with development were driven by changes in YLLs.\ud \ud Interpretation Neurological disorders are an important cause of disability and death worldwide. Globally, the burden\ud of neurological disorders has increased substantially over the past 25 years because of expanding population numbers\ud and ageing, despite substantial decreases in mortality rates from stroke and communicable neurological disorders.\ud The number of patients who will need care by clinicians with expertise in neurological conditions will continue to\ud grow in coming decades. Policy makers and health-care providers should be aware of these trends to provide adequate\ud services.\ud \ud Funding Bill & Melinda Gates Foundation.
Published: 2017

33. Current use and acceptability of novel diagnostic tests for active tuberculosis: A worldwide survey|Uso atual e aceitabilidade de novos testes diagnósticos para tuberculose ativa: Um inquérito mundial

Author: Amicosante, M, D'Ambrosio, L, Munoz, M, Mello, Fcq, Tebruegge, M, Chegou, Nn, Seghrouchni, F, Centis, R, Goletti, D, Bothamley, G, Migliori, Gb, Al-Hattami, Aam, Kebede, A, Rendon, A, Garcia-Basteiro, Al, Abdulmumuni, As, Nota, A, Pace-Asciak, A, Loxton, A, Bhowmik, A, Catanzaro, A, Worku, A, Kabeer, Bsa, Savic, B, Nselebete, Bb, Montesano, C, Montagnani, C, Mammina, C, Nkenfou, C, Kvasnovsky, C, Braz, C, Blazquez-Gamero, D, Cirillo, Dm, Huluka, Dk, Handayani, D, Papaventsis, D, Palmero, D, Catanzaro, D, Chanda, D, Gurbanova, E, Sobh, E, Gebremariam, Fm, Pradel, Fk, Brindicci, G, Sotgiu, G, De Iaco, G, Kahenya, G, Nwankwo, G, Hoffmann, H, Mutunzi, H, Kenechukwu, I, Pavic, I, Mukeba, J, Wambugu, J, Abdulsemed, Ka, Ukwaja, Kn, Fattorini, L, Guglielmetti, L, Zammarchi, L, Anibarro, L, Zijenah, Ls, Lipman, M, Ivanovska, M, Nikolova, M, Joya, Mc, Bonnet, M, Chisale, M, Jachym, Mf, Elmi, M, Gadanya, Ma, Getahun, M, Veziris, N, Hanson-Nortey, Nn, Nwankwo, Ono, Del Monte, P, Fourati, R, Laniado-Laborin, R, Lodha, R, Wong, R, Bhebhe, R, de la Tour, R, Ferreira, Rt, Boy, S, Eyanu, S, Singh, S, Tafaj, S, Joosten, Sa, Callens, S, Moyo, S, Tao, Tm, Gebremariam, Th, Meshak, Tp, Perez-Porcuna, T, Vasankari, T, Rolla, Vc, Singh, V, Ratageri, Vh, Milanov, V, Rosati, Y, and Fuentes-Alcala, Z
Subjects: Adult, Male, Attitude of Health Personnel, Female, Global Health, Humans, Interviews as Topic, Middle Aged, Reagent Kits, Diagnostic, Sensitivity and Specificity, Tuberculosis, Young Adult, Mycobacterium tuberculosis, Settore MED/04, Reagent Kits, Diagnostic
Published: 2017

34. Associations between Family Structure, Parental Monitoring and Marijuana Use among Adolescents in Jamaica: Findings from Nationally Representative Data

Author: Oshi, DC, primary, Abel, WD, additional, Ricketts-Roomes, T, additional, Agu, CF, additional, Oshi, SN, additional, Harrison, J, additional, Smith, K, additional, Atkinson, U, additional, Clarke, P, additional, Whitehorne-Smith, P, additional, and Ukwaja, KN, additional
Published: 2017
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35. Healthcare Access and Quality Index based on mortality from causes amenable to personal health care in 195 countries and territories, 1990–2015: a novel analysis from the Global Burden of Disease Study 2015

Author: Barber, RM, Fullman, N, Sorensen, RJD, Bollyky, T, McKee, M, Nolte, E, Abajobir, AA, Abate, KH, Abbafati, C, Abbas, KM, Abd-Allah, F, Abdulle, AM, Abdurahman, AA, Abera, SF, Abraham, B, Abreha, GF, Adane, K, Adelekan, AL, Adetifa, IMO, Afshin, A, Agarwal, A, Agarwal, SK, Agarwal, S, Agrawal, A, Kiadaliri, AA, Ahmadi, A, Ahmed, KY, Ahmed, MB, Akinyemi, RO, Akinyemiju, TF, Akseer, N, Al-Aly, Z, Alam, K, Alam, N, Alam, SS, Alemu, ZA, Alene, KA, Alexander, L, Ali, R, Ali, SD, Alizadeh-Navaei, R, Alkerwi, A, Alla, F, Allebeck, P, Allen, C, Al-Raddadi, R, Alsharif, U, Altirkawi, KA, Martin, EA, Alvis-Guzman, N, Amare, AT, Amini, E, Ammar, W, Amo-Adjei, J, Amoako, YA, Anderson, BO, Androudi, S, Ansari, H, Ansha, MG, Antonio, CAT, Ärnlöv, J, Artaman, A, Asayesh, H, Assadi, R, Astatkie, A, Atey, TM, Atique, S, Atnafu, NT, Atre, SR, Avila-Burgos, L, Avokpaho, EFGA, Quintanilla, BPA, Awasthi, A, Ayele, NN, Azzopardi, P, Saleem, HOB, Bärnighausen, T, Bacha, U, Badawi, A, Banerjee, A, Barac, A, Barboza, MA, Barker-Collo, SL, Barrero, LH, Basu, S, Baune, BT, Baye, K, Bayou, YT, Bazargan-Hejazi, S, Bedi, N, Beghi, E, Béjot, Y, Bello, AK, Bennett, DA, Bensenor, IM, Berhane, A, Bernabé, E, Bernal, OA, Beyene, AS, Beyene, TJ, Bhutta, ZA, Biadgilign, S, Bikbov, B, Birlik, SM, Birungi, C, Biryukov, S, Bisanzio, D, Bizuayehu, HM, Bose, D, Brainin, M, Brauer, M, Brazinova, A, Breitborde, NJK, Brenner, H, Butt, ZA, Cárdenas, R, Cahuana-Hurtado, L, Campos-Nonato, IR, Car, J, Carrero, JJ, Casey, D, Caso, V, Castañeda-Orjuela, CA, Rivas, JC, Catalá-López, F, Cecilio, P, Cercy, K, Charlson, FJ, Chen, AZ, Chew, A, Chibalabala, M, Chibueze, CE, Chisumpa, VH, Chitheer, AA, Chowdhury, R, Christensen, H, Christopher, DJ, Ciobanu, LG, Cirillo, M, Coggeshall, MS, Cooper, LT, Cortinovis, M, Crump, JA, Dalal, K, Danawi, H, Dandona, L, Dandona, R, Dargan, PI, das Neves, J, Davey, G, Davitoiu, DV, Davletov, K, De Leo, D, Del Gobbo, LC, del Pozo-Cruz, B, Dellavalle, RP, Deribe, K, Deribew, A, Des Jarlais, DC, Dey, S, Dharmaratne, SD, Dicker, D, Ding, EL, Dokova, K, Dorsey, ER, Doyle, KE, Dubey, M, Ehrenkranz, R, Ellingsen, CL, Elyazar, I, Enayati, A, Ermakov, SP, Eshrati, B, Esteghamati, A, Estep, K, Fürst, T, Faghmous, IDA, Fanuel, FBB, Faraon, EJA, Farid, TA, Farinha, CSES, Faro, A, Farvid, MS, Farzadfar, F, Feigin, VL, Feigl, AB, Fereshtehnejad, S-M, Fernandes, JG, Fernandes, JC, Feyissa, TR, Fischer, F, Fitzmaurice, C, Fleming, TD, Foigt, N, Foreman, KJ, Forouzanfar, MH, Franklin, RC, Frostad, J, G/hiwot, TT, Gakidou, E, Gambashidze, K, Gamkrelidze, A, Gao, W, Garcia-Basteiro, AL, Gebre, T, Gebremedhin, AT, Gebremichael, MW, Gebru, AA, Gelaye, AA, Geleijnse, JM, Genova-Maleras, R, Gibney, KB, Giref, AZ, Gishu, MD, Giussani, G, Godwin, WW, Gold, A, Goldberg, EM, Gona, PN, Goodridge, A, Gopalani, SV, Goto, A, Graetz, N, Greaves, F, Griswold, M, Guban, PI, Gugnani, HC, Gupta, PC, Gupta, R, Gupta, T, Gupta, V, Habtewold, TD, Hafezi-Nejad, N, Haile, D, Hailu, AD, Hailu, GB, Hakuzimana, A, Hamadeh, RR, Hambisa, MT, Hamidi, S, Hammami, M, Hankey, GJ, Hao, Y, Harb, HL, Hareri, HA, Haro, JM, Hassanvand, MS, Havmoeller, R, Hay, RJ, Hay, SI, Hendrie, D, Heredia-Pi, IB, Hoek, HW, Horino, M, Horita, N, Hosgood, HD, Htet, AS, Hu, G, Huang, H, Huang, JJ, Huntley, BM, Huynh, C, Iburg, KM, Ileanu, BV, Innos, K, Irenso, AA, Jahanmehr, N, Jakovljevic, MB, James, P, James, SL, Javanbakht, M, Jayaraman, SP, Jayatilleke, AU, Jeemon, P, Jha, V, John, D, Johnson, C, Johnson, SC, Jonas, JB, Juel, K, Kabir, Z, Kalkonde, Y, Kamal, R, Kan, H, Karch, A, Karema, CK, Karimi, SM, Kasaeian, A, Kassebaum, NJ, Kastor, A, Katikireddi, SV, Kazanjan, K, Keiyoro, PN, Kemmer, L, Kemp, AH, Kengne, AP, Kerbo, AA, Kereselidze, M, Kesavachandran, CN, Khader, YS, Khalil, I, Khan, AR, Khan, EA, Khan, G, Khang, Y-H, Khoja, ATA, Khonelidze, I, Khubchandani, J, Kibret, GD, Kim, D, Kim, P, Kim, YJ, Kimokoti, RW, Kinfu, Y, Kissoon, N, Kivipelto, M, Kokubo, Y, Kolk, A, Kolte, D, Kopec, JA, Kosen, S, Koul, PA, Koyanagi, A, Kravchenko, M, Krishnaswami, S, Krohn, KJ, Defo, BK, Bicer, BK, Kuipers, EJ, Kulkarni, VS, Kumar, GA, Kumsa, FA, Kutz, M, Kyu, HH, Lager, ACJ, Lal, A, Lal, DK, Lalloo, R, Lallukka, T, Lan, Q, Langan, SM, Lansingh, VC, Larson, HJ, Larsson, A, Laryea, DO, Latif, AA, Lawrynowicz, AEB, Leasher, JL, Leigh, J, Leinsalu, M, Leshargie, CT, Leung, J, Leung, R, Levi, M, Liang, X, Lim, SS, Lind, M, Linn, S, Lipshultz, SE, Liu, P, Liu, Y, Lo, L-T, Logroscino, G, Lopez, AD, Lorch, SA, Lotufo, PA, Lozano, R, Lunevicius, R, Lyons, RA, Macarayan, ERK, Mackay, MT, El Razek, HMA, El Razek, MMA, Mahdavi, M, Majeed, A, Malekzadeh, R, Malta, DC, Mantovani, LG, Manyazewal, T, Mapoma, CC, Marcenes, W, Marks, GB, Marquez, N, Martinez-Raga, J, Marzan, MB, Massano, J, Mathur, MR, Maulik, PK, Mazidi, M, McAlinden, C, McGrath, JJ, McNellan, C, Meaney, PA, Mehari, A, Mehndiratta, MM, Meier, T, Mekonnen, AB, Meles, KG, Memish, ZA, Mengesha, MM, Mengiste, DT, Mengistie, MA, Menota, BG, Mensah, GA, Mereta, ST, Meretoja, A, Meretoja, TJ, Mezgebe, HB, Micha, R, Millear, A, Mills, EJ, Minnig, S, Mirarefin, M, Mirrakhimov, EM, Mock, CN, Mohammad, KA, Mohammed, S, Mohanty, SK, Mokdad, AH, Mola, GLD, Molokhia, M, Monasta, L, Montico, M, Moradi-Lakeh, M, Moraga, P, Morawska, L, Mori, R, Moses, M, Mueller, UO, Murthy, S, Musa, KI, Nachega, JB, Nagata, C, Nagel, G, Naghavi, M, Naheed, A, Naldi, L, Nangia, V, Nascimento, BR, Negoi, I, Neupane, SP, Newton, CR, Ng, M, Ngalesoni, FN, Ngunjiri, JW, Nguyen, G, Ningrum, DNA, Nolte, S, Nomura, M, Norheim, OF, Norrving, B, Noubiap, JJN, Obermeyer, CM, Ogbo, FA, Oh, I-H, Okoro, A, Oladimeji, O, Olagunju, AT, Olivares, PR, Olsen, HE, Olusanya, BO, Olusanya, JO, Opio, JN, Oren, E, Ortiz, A, Osborne, RH, Osman, M, Owolabi, MO, PA, M, Pain, AW, Pakhale, S, Castillo, EP, Pana, A, Papachristou, C, Parsaeian, M, Patel, T, Patton, GC, Paudel, D, Paul, VK, Pearce, N, Pereira, DM, Perez-Padilla, R, Perez-Ruiz, F, Perico, N, Pesudovs, K, Petzold, M, Phillips, MR, Pigott, DM, Pillay, JD, Pinho, C, Polinder, S, Pond, CD, Prakash, V, Purwar, M, Qorbani, M, Quistberg, DA, Radfar, A, Rafay, A, Rahimi, K, Rahimi-Movaghar, V, Rahman, M, Rahman, MHU, Rai, RK, Ram, U, Rana, SM, Rankin, Z, Rao, PV, Rao, PC, Rawaf, S, Rego, MAS, Reitsma, M, Remuzzi, G, Renzaho, AMNN, Resnikoff, S, Rezaei, S, Rezai, MS, Ribeiro, AL, Roba, HS, Rokni, MB, Ronfani, L, Roshandel, G, Roth, GA, Rothenbacher, D, Roy, NK, Sachdev, PS, Sackey, BB, Saeedi, MY, Safiri, S, Sagar, R, Sahraian, MA, Saleh, MM, Salomon, JA, Samy, AM, Sanabria, JR, Sanchez-Niño, MD, Sandar, L, Santos, IS, Santos, JV, Milicevic, MMS, Sarmiento-Suarez, R, Sartorius, B, Satpathy, M, Savic, M, Sawhney, M, Saylan, MI, Schöttker, B, Schutte, AE, Schwebel, DC, Seedat, S, Seid, AM, Seifu, CN, Sepanlou, SG, Serdar, B, Servan-Mori, EE, Setegn, T, Shackelford, KA, Shaheen, A, Shahraz, S, Shaikh, MA, Shakh-Nazarova, M, Shamsipour, M, Islam, SMS, Sharma, J, Sharma, R, She, J, Sheikhbahaei, S, Shen, J, Shi, P, Shigematsu, M, Shin, M-J, Shiri, R, Shoman, H, Shrime, MG, Sibamo, ELS, Sigfusdottir, ID, Silva, DAS, Silveira, DGA, Sindi, S, Singh, A, Singh, JA, Singh, OP, Singh, PK, Singh, V, Sinke, AH, Sinshaw, AE, Skirbekk, V, Sliwa, K, Smith, A, Sobngwi, E, Soneji, S, Soriano, JB, Sousa, TCM, Sposato, LA, Sreeramareddy, CT, Stathopoulou, V, Steel, N, Steiner, C, Steinke, S, Stokes, MA, Stranges, S, Strong, M, Stroumpoulis, K, Sturua, L, Sufiyan, MB, Suliankatchi, RA, Sun, J, Sur, P, Swaminathan, S, Sykes, BL, Tabarés-Seisdedos, R, Tabb, KM, Taffere, GR, Talongwa, RT, Tarajia, M, Tavakkoli, M, Taveira, N, Teeple, S, Tegegne, TK, Tehrani-Banihashemi, A, Tekelab, T, Tekle, DY, Shifa, GT, Terkawi, AS, Tesema, AG, Thakur, JS, Thomson, AJ, Tillmann, T, Tiruye, TY, Tobe-Gai, R, Tonelli, M, Topor-Madry, R, Tortajada, M, Troeger, C, Truelsen, T, Tura, AK, Uchendu, US, Ukwaja, KN, Undurraga, EA, Uneke, CJ, Uthman, OA, van Boven, JFM, Van Dingenen, R, Varughese, S, Vasankari, T, Venketasubramanian, N, Violante, FS, Vladimirov, SK, Vlassov, VV, Vollset, SE, Vos, T, Wagner, JA, Wakayo, T, Waller, SG, Walson, JL, Wang, H, Wang, Y-P, Watkins, DA, Weiderpass, E, Weintraub, RG, Wen, C-P, Werdecker, A, Wesana, J, Westerman, R, Whiteford, HA, Wilkinson, JD, Wiysonge, CS, Woldeyes, BG, Wolfe, CDA, Won, S, Workicho, A, Workie, SB, Wubshet, M, Xavier, D, Xu, G, Yadav, AK, Yaghoubi, M, Yakob, B, Yan, LL, Yano, Y, Yaseri, M, Yimam, HH, Yip, P, Yonemoto, N, Yoon, S-J, Younis, MZ, Yu, C, Zaidi, Z, El Sayed Zaki, M, Zambrana-Torrelio, C, Zapata, T, Zenebe, ZM, Zodpey, S, Zoeckler, L, Zuhlke, LJ, Murray, CJL, Barber, RM, Fullman, N, Sorensen, RJD, Bollyky, T, McKee, M, Nolte, E, Abajobir, AA, Abate, KH, Abbafati, C, Abbas, KM, Abd-Allah, F, Abdulle, AM, Abdurahman, AA, Abera, SF, Abraham, B, Abreha, GF, Adane, K, Adelekan, AL, Adetifa, IMO, Afshin, A, Agarwal, A, Agarwal, SK, Agarwal, S, Agrawal, A, Kiadaliri, AA, Ahmadi, A, Ahmed, KY, Ahmed, MB, Akinyemi, RO, Akinyemiju, TF, Akseer, N, Al-Aly, Z, Alam, K, Alam, N, Alam, SS, Alemu, ZA, Alene, KA, Alexander, L, Ali, R, Ali, SD, Alizadeh-Navaei, R, Alkerwi, A, Alla, F, Allebeck, P, Allen, C, Al-Raddadi, R, Alsharif, U, Altirkawi, KA, Martin, EA, Alvis-Guzman, N, Amare, AT, Amini, E, Ammar, W, Amo-Adjei, J, Amoako, YA, Anderson, BO, Androudi, S, Ansari, H, Ansha, MG, Antonio, CAT, Ärnlöv, J, Artaman, A, Asayesh, H, Assadi, R, Astatkie, A, Atey, TM, Atique, S, Atnafu, NT, Atre, SR, Avila-Burgos, L, Avokpaho, EFGA, Quintanilla, BPA, Awasthi, A, Ayele, NN, Azzopardi, P, Saleem, HOB, Bärnighausen, T, Bacha, U, Badawi, A, Banerjee, A, Barac, A, Barboza, MA, Barker-Collo, SL, Barrero, LH, Basu, S, Baune, BT, Baye, K, Bayou, YT, Bazargan-Hejazi, S, Bedi, N, Beghi, E, Béjot, Y, Bello, AK, Bennett, DA, Bensenor, IM, Berhane, A, Bernabé, E, Bernal, OA, Beyene, AS, Beyene, TJ, Bhutta, ZA, Biadgilign, S, Bikbov, B, Birlik, SM, Birungi, C, Biryukov, S, Bisanzio, D, Bizuayehu, HM, Bose, D, Brainin, M, Brauer, M, Brazinova, A, Breitborde, NJK, Brenner, H, Butt, ZA, Cárdenas, R, Cahuana-Hurtado, L, Campos-Nonato, IR, Car, J, Carrero, JJ, Casey, D, Caso, V, Castañeda-Orjuela, CA, Rivas, JC, Catalá-López, F, Cecilio, P, Cercy, K, Charlson, FJ, Chen, AZ, Chew, A, Chibalabala, M, Chibueze, CE, Chisumpa, VH, Chitheer, AA, Chowdhury, R, Christensen, H, Christopher, DJ, Ciobanu, LG, Cirillo, M, Coggeshall, MS, Cooper, LT, Cortinovis, M, Crump, JA, Dalal, K, Danawi, H, Dandona, L, Dandona, R, Dargan, PI, das Neves, J, Davey, G, Davitoiu, DV, Davletov, K, De Leo, D, Del Gobbo, LC, del Pozo-Cruz, B, Dellavalle, RP, Deribe, K, Deribew, A, Des Jarlais, DC, Dey, S, Dharmaratne, SD, Dicker, D, Ding, EL, Dokova, K, Dorsey, ER, Doyle, KE, Dubey, M, Ehrenkranz, R, Ellingsen, CL, Elyazar, I, Enayati, A, Ermakov, SP, Eshrati, B, Esteghamati, A, Estep, K, Fürst, T, Faghmous, IDA, Fanuel, FBB, Faraon, EJA, Farid, TA, Farinha, CSES, Faro, A, Farvid, MS, Farzadfar, F, Feigin, VL, Feigl, AB, Fereshtehnejad, S-M, Fernandes, JG, Fernandes, JC, Feyissa, TR, Fischer, F, Fitzmaurice, C, Fleming, TD, Foigt, N, Foreman, KJ, Forouzanfar, MH, Franklin, RC, Frostad, J, G/hiwot, TT, Gakidou, E, Gambashidze, K, Gamkrelidze, A, Gao, W, Garcia-Basteiro, AL, Gebre, T, Gebremedhin, AT, Gebremichael, MW, Gebru, AA, Gelaye, AA, Geleijnse, JM, Genova-Maleras, R, Gibney, KB, Giref, AZ, Gishu, MD, Giussani, G, Godwin, WW, Gold, A, Goldberg, EM, Gona, PN, Goodridge, A, Gopalani, SV, Goto, A, Graetz, N, Greaves, F, Griswold, M, Guban, PI, Gugnani, HC, Gupta, PC, Gupta, R, Gupta, T, Gupta, V, Habtewold, TD, Hafezi-Nejad, N, Haile, D, Hailu, AD, Hailu, GB, Hakuzimana, A, Hamadeh, RR, Hambisa, MT, Hamidi, S, Hammami, M, Hankey, GJ, Hao, Y, Harb, HL, Hareri, HA, Haro, JM, Hassanvand, MS, Havmoeller, R, Hay, RJ, Hay, SI, Hendrie, D, Heredia-Pi, IB, Hoek, HW, Horino, M, Horita, N, Hosgood, HD, Htet, AS, Hu, G, Huang, H, Huang, JJ, Huntley, BM, Huynh, C, Iburg, KM, Ileanu, BV, Innos, K, Irenso, AA, Jahanmehr, N, Jakovljevic, MB, James, P, James, SL, Javanbakht, M, Jayaraman, SP, Jayatilleke, AU, Jeemon, P, Jha, V, John, D, Johnson, C, Johnson, SC, Jonas, JB, Juel, K, Kabir, Z, Kalkonde, Y, Kamal, R, Kan, H, Karch, A, Karema, CK, Karimi, SM, Kasaeian, A, Kassebaum, NJ, Kastor, A, Katikireddi, SV, Kazanjan, K, Keiyoro, PN, Kemmer, L, Kemp, AH, Kengne, AP, Kerbo, AA, Kereselidze, M, Kesavachandran, CN, Khader, YS, Khalil, I, Khan, AR, Khan, EA, Khan, G, Khang, Y-H, Khoja, ATA, Khonelidze, I, Khubchandani, J, Kibret, GD, Kim, D, Kim, P, Kim, YJ, Kimokoti, RW, Kinfu, Y, Kissoon, N, Kivipelto, M, Kokubo, Y, Kolk, A, Kolte, D, Kopec, JA, Kosen, S, Koul, PA, Koyanagi, A, Kravchenko, M, Krishnaswami, S, Krohn, KJ, Defo, BK, Bicer, BK, Kuipers, EJ, Kulkarni, VS, Kumar, GA, Kumsa, FA, Kutz, M, Kyu, HH, Lager, ACJ, Lal, A, Lal, DK, Lalloo, R, Lallukka, T, Lan, Q, Langan, SM, Lansingh, VC, Larson, HJ, Larsson, A, Laryea, DO, Latif, AA, Lawrynowicz, AEB, Leasher, JL, Leigh, J, Leinsalu, M, Leshargie, CT, Leung, J, Leung, R, Levi, M, Liang, X, Lim, SS, Lind, M, Linn, S, Lipshultz, SE, Liu, P, Liu, Y, Lo, L-T, Logroscino, G, Lopez, AD, Lorch, SA, Lotufo, PA, Lozano, R, Lunevicius, R, Lyons, RA, Macarayan, ERK, Mackay, MT, El Razek, HMA, El Razek, MMA, Mahdavi, M, Majeed, A, Malekzadeh, R, Malta, DC, Mantovani, LG, Manyazewal, T, Mapoma, CC, Marcenes, W, Marks, GB, Marquez, N, Martinez-Raga, J, Marzan, MB, Massano, J, Mathur, MR, Maulik, PK, Mazidi, M, McAlinden, C, McGrath, JJ, McNellan, C, Meaney, PA, Mehari, A, Mehndiratta, MM, Meier, T, Mekonnen, AB, Meles, KG, Memish, ZA, Mengesha, MM, Mengiste, DT, Mengistie, MA, Menota, BG, Mensah, GA, Mereta, ST, Meretoja, A, Meretoja, TJ, Mezgebe, HB, Micha, R, Millear, A, Mills, EJ, Minnig, S, Mirarefin, M, Mirrakhimov, EM, Mock, CN, Mohammad, KA, Mohammed, S, Mohanty, SK, Mokdad, AH, Mola, GLD, Molokhia, M, Monasta, L, Montico, M, Moradi-Lakeh, M, Moraga, P, Morawska, L, Mori, R, Moses, M, Mueller, UO, Murthy, S, Musa, KI, Nachega, JB, Nagata, C, Nagel, G, Naghavi, M, Naheed, A, Naldi, L, Nangia, V, Nascimento, BR, Negoi, I, Neupane, SP, Newton, CR, Ng, M, Ngalesoni, FN, Ngunjiri, JW, Nguyen, G, Ningrum, DNA, Nolte, S, Nomura, M, Norheim, OF, Norrving, B, Noubiap, JJN, Obermeyer, CM, Ogbo, FA, Oh, I-H, Okoro, A, Oladimeji, O, Olagunju, AT, Olivares, PR, Olsen, HE, Olusanya, BO, Olusanya, JO, Opio, JN, Oren, E, Ortiz, A, Osborne, RH, Osman, M, Owolabi, MO, PA, M, Pain, AW, Pakhale, S, Castillo, EP, Pana, A, Papachristou, C, Parsaeian, M, Patel, T, Patton, GC, Paudel, D, Paul, VK, Pearce, N, Pereira, DM, Perez-Padilla, R, Perez-Ruiz, F, Perico, N, Pesudovs, K, Petzold, M, Phillips, MR, Pigott, DM, Pillay, JD, Pinho, C, Polinder, S, Pond, CD, Prakash, V, Purwar, M, Qorbani, M, Quistberg, DA, Radfar, A, Rafay, A, Rahimi, K, Rahimi-Movaghar, V, Rahman, M, Rahman, MHU, Rai, RK, Ram, U, Rana, SM, Rankin, Z, Rao, PV, Rao, PC, Rawaf, S, Rego, MAS, Reitsma, M, Remuzzi, G, Renzaho, AMNN, Resnikoff, S, Rezaei, S, 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V, Steel, N, Steiner, C, Steinke, S, Stokes, MA, Stranges, S, Strong, M, Stroumpoulis, K, Sturua, L, Sufiyan, MB, Suliankatchi, RA, Sun, J, Sur, P, Swaminathan, S, Sykes, BL, Tabarés-Seisdedos, R, Tabb, KM, Taffere, GR, Talongwa, RT, Tarajia, M, Tavakkoli, M, Taveira, N, Teeple, S, Tegegne, TK, Tehrani-Banihashemi, A, Tekelab, T, Tekle, DY, Shifa, GT, Terkawi, AS, Tesema, AG, Thakur, JS, Thomson, AJ, Tillmann, T, Tiruye, TY, Tobe-Gai, R, Tonelli, M, Topor-Madry, R, Tortajada, M, Troeger, C, Truelsen, T, Tura, AK, Uchendu, US, Ukwaja, KN, Undurraga, EA, Uneke, CJ, Uthman, OA, van Boven, JFM, Van Dingenen, R, Varughese, S, Vasankari, T, Venketasubramanian, N, Violante, FS, Vladimirov, SK, Vlassov, VV, Vollset, SE, Vos, T, Wagner, JA, Wakayo, T, Waller, SG, Walson, JL, Wang, H, Wang, Y-P, Watkins, DA, Weiderpass, E, Weintraub, RG, Wen, C-P, Werdecker, A, Wesana, J, Westerman, R, Whiteford, HA, Wilkinson, JD, Wiysonge, CS, Woldeyes, BG, Wolfe, CDA, Won, S, Workicho, A, Workie, SB, Wubshet, M, Xavier, D, Xu, G, Yadav, AK, Yaghoubi, M, Yakob, B, Yan, LL, Yano, Y, Yaseri, M, Yimam, HH, Yip, P, Yonemoto, N, Yoon, S-J, Younis, MZ, Yu, C, Zaidi, Z, El Sayed Zaki, M, Zambrana-Torrelio, C, Zapata, T, Zenebe, ZM, Zodpey, S, Zoeckler, L, Zuhlke, LJ, and Murray, CJL
Published: 2017

36. Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970-2016: a systematic analysis for the Global Burden of Disease Study 2016

Author: Wang, H, Abajobir, AA, Abate, KH, Abbafati, C, Abbas, KM, Abd-Allah, F, Abera, SF, Abraha, HN, Abu-Raddad, LJ, Abu-Rmeileh, NME, Adedeji, IA, Adedoyin, RA, Adetifa, IMO, Adetokunboh, O, Afshin, A, Aggarwal, R, Agrawal, A, Agrawal, S, Kiadaliri, AA, Ahmed, MB, Aichour, AN, Aichour, I, Aichour, MTE, Aiyar, S, Akanda, S, Akinyemiju, TF, Akseer, N, Al-Eyadhy, A, Al Lami, FH, Alabed, S, Alahdab, F, Al-Aly, Z, Alam, K, Alam, N, Alasfoor, D, Aldridge, RW, Alene, KA, Alhabib, S, Ali, R, Alizadeh-Navaei, R, Aljunid, SM, Alkaabi, JM, Alkerwi, A, Alla, F, Allam, SD, Allebeck, P, Al-Raddadi, R, Alsharif, U, Altirkawi, KA, Martin, EA, Alvis-Guzman, N, Amare, AT, Ameh, EA, Amini, E, Ammar, W, Amoako, YA, Anber, N, Andrei, CL, Androudi, S, Ansari, H, Ansha, MG, Antonio, CAT, Anwari, P, Arnlov, J, Arora, M, Al, A, Aryal, KK, Asayesh, H, Asgedom, SW, Asghar, RJ, Assadi, R, Atey, TM, Atre, SR, Avila-Burgos, L, Avokpaho, EFGA, Awasthi, A, Quintanilla, BPA, Babalola, TK, Bacha, U, Badawi, A, Balakrishnan, K, Balalla, S, Barac, A, Barber, RM, Barboza, MA, Barker-Collo, SL, Barnighausen, T, Barquera, S, Barregard, L, Barrero, LH, Baune, BT, Bazargan-Hejazi, S, Bedi, N, Beghi, E, Bejot, Y, Bekele, BB, Bell, ML, Bello, AK, Bennett, DA, Bennett, JR, Bensenor, IM, Benson, J, Berhane, A, Berhe, DF, Bernabe, E, Beuran, M, Beyene, AS, Bhala, N, Bhansali, A, Bhaumik, S, Bhutta, ZA, Bikbov, B, Birungi, C, Biryukov, S, Bisanzio, D, Bizuayehu, HM, Bjerregaard, P, Blosser, CD, Boneya, DJ, Boufous, S, Bourne, RRA, Brazinova, A, Breitborde, NJK, Brenner, H, Brugha, TS, Bukhman, G, Negesa, L, Bulto, B, Bumgarner, BR, Burch, M, Butt, ZA, Cahill, LE, Cahuana-Hurtado, L, Campos-Nonato, IR, Car, J, Car, M, Crdenas, R, Carpenter, DO, Carrero, JJ, Carter, A, Castaneda-Orjuela, CA, Rivas, JC, Castro, FF, Castro, RE, Catala-Lopez, F, Chen, H, Chiang, PP-C, Chibalabala, M, Chisumpa, VH, Chitheer, AA, Choi, J-YJ, Christensen, H, Christopher, DJ, Ciobanu, LG, Cirillo, M, Cohen, AJ, Colquhoun, SM, 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Natarajan, G, Negoi, I, Cuong, TN, Ningrum, DNA, Nisar, MI, Nomura, M, Vuong, MN, Norheim, OF, Norrving, B, Noubiap, JJN, Nyakarahuka, L, Obermeyer, CM, O'Donnell, MJ, Ogbo, FA, Oh, I-H, Okoro, A, Oladimeji, O, Olagunju, AT, Olusanya, BO, Olusanya, JO, Oren, E, Ortiz, A, Osgood-Zimmerman, A, Ota, E, Owolabi, MO, Oyekale, AS, Pa, M, Pacella, RE, Pakhale, S, Pana, A, Panda, BK, Panda-Jonas, S, Park, E-K, Parsaeian, M, Patel, T, Patten, SB, Patton, GC, Paudel, D, Pereira, DM, Perez-Padilla, R, Perez-Ruiz, F, Perico, N, Pervaiz, A, Pesudovs, K, Peterson, CB, Petri, WA, Petzold, M, Phillips, MR, Piel, FB, Pigott, DM, Pishgar, F, Plass, D, Polinder, S, Popova, S, Postma, MJ, Poulton, RG, Pourmalek, F, Prasad, N, Purwar, M, Qorbani, M, Rabiee, RHS, Radfar, A, Rafay, A, Rahimi-Movaghar, A, Rahimi-Movaghar, V, Rahman, M, Rahman, MHU, Rahman, SU, Rai, RK, Rajsic, S, Ram, U, Rana, SM, Ranabhat, CL, Rao, PV, Rawaf, S, Ray, SE, Rego, MAS, Rehm, J, Reiner, RC, Remuzzi, G, Renzaho, AMNN, Resnikoff, S, Rezaei, S, Rezai, MS, Ribeiro, AL, Rokni, MB, Ronfani, L, Roshandel, G, Roth, GA, Rothenbacher, D, Roy, A, Rubagotti, E, Ruhago, GM, Saadat, S, Sabde, YD, Sachdev, PS, Sadat, N, Safdarian, M, Safiri, SSS, Sagar, R, Sahathevan, R, Sahebkar, A, Sahraian, MA, Salama, J, Salamati, P, Salomon, JA, Salvi, SS, Samy, AM, Sanabria, JR, Sanchez-Nino, MD, Santos, IS, Milicevic, MMS, Sarmiento-Suarez, R, Sartorius, B, Satpathy, M, Sawhney, M, Saxena, S, Saylan, MI, Schmidt, MI, Schneider, IJC, Schutte, AE, Schwebel, DC, Schwendicke, F, Seedat, S, Seid, AM, Sepanlou, SG, Servan-Mori, EE, Shackelford, KA, Shaheen, A, Shahraz, S, Shaikh, MA, Shamsipour, M, Shamsizadeh, M, Islam, SMS, Sharma, J, Sharma, R, She, J, Shen, J, Shetty, BP, Shi, P, Shibuya, K, Shigematsu, M, Shiri, R, Shiue, I, Shrime, MG, Sigfusdottir, ID, Silberberg, DH, Silpakit, N, Silva, DAS, Silva, JP, Silveira, DGA, Sindi, S, Singh, A, Singh, JA, Singh, PK, Singh, V, Sinha, DN, Skiadaresi, E, Sligar, A, Smith, DL, Sobaih, BHA, Sobngwi, E, Soneji, S, Soriano, JB, Sreeramareddy, CT, Srinivasan, V, Stathopoulou, V, Steel, N, Stein, DJ, Steiner, C, Stockl, H, Stokes, MA, Strong, M, Sufiyan, MB, Suliankatchi, RA, Sunguya, BF, Sur, PJ, Swaminathan, S, Sykes, BL, Szoeke, CEI, Tabares-Seisdedos, R, Tadakamadla, SK, Tadese, F, Tandon, N, Tanne, D, Tarajia, M, Tavakkoli, M, Taveira, N, Tehrani-Banihashemi, A, Tekelab, T, Tekle, DY, Shifa, GT, Temsah, M-H, Terkawi, AS, Tesema, CL, Tesssema, B, Theis, A, Thomas, N, Thompson, AH, Thomson, AJ, Thrift, AG, Tiruye, TY, Tobe-Gai, R, Tonelli, M, Topor-Madry, R, Topouzis, F, Tortajada, M, Tran, BX, Trujillo, TTU, Tsilimparis, N, Tuem, KB, Tuzcu, EM, Tyrovolas, S, Ukwaja, KN, Undurraga, EA, Uthman, OA, Uzochukwu, BSC, van Boven, JFM, Varakin, YY, Varughese, S, Vasankari, T, Vasconcelos, AMN, Venketasubramanian, N, Vidavalur, R, Violante, FS, Vishnu, A, Vladimirov, SK, Vlassov, VV, Vollset, SE, Vos, T, Waid, JL, Wakayo, T, Wang, Y-P, Weichenthal, S, Weiderpass, E, Weintraub, RG, Werdecker, A, Wesana, J, Wijeratne, T, Wilkinson, JD, Wiysonge, CS, Woldeyes, BG, Wolfe, CDA, Workicho, A, Workie, SB, Xavier, D, Xu, G, Yaghoubi, M, Yakob, B, Yalew, AZ, Yan, LL, Yano, Y, Yaseri, M, Ye, P, Yimam, HH, Yip, P, Yirsaw, BD, Yonemoto, N, Yoon, S-J, Yotebieng, M, Younis, MZ, Zaidi, Z, Zaki, MES, Zeeb, H, Zenebe, ZM, Zerfu, TA, Zhang, AL, Zhang, X, Zodpey, S, Zuhlke, LJ, Lopez, AD, and Murray, CJL
Published: 2017

37. Global, regional, and national burden of neurological disorders during 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015

Author: Feigin, V, Abajobir, A, Abate, K, Abd-Allah, F, Abdulle, A, Abera, S, Abyu, G, Ahmed, M, Aichour, A, Aichour, I, Aichour, M, Akinyemi, R, Alabed, S, Al-Raddadi, R, Alvis-Guzman, N, Amare, A, Ansari, H, Anwari, P, Ärnlöv, J, Asayesh, H, Asgedom, S, Atey, T, Avila-Burgos, L, Frinel, E, Avokpaho, G, Barac, A, Barboza, M, Barker-Collo, S, Bärnighausen, T, Bedi, N, Beghi, E, Bennett, D, Bensenor, I, Berhane, A, Betsu, B, Bhaumik, S, Birlik, S, Biryukov, S, Boneya, D, Bulto, L, Carabin, H, Casey, D, Castañeda-Orjuela, C, Catalá-López, F, Chen, H, Chitheer, A, Chowdhury, R, Christensen, H, Dandona, L, Dandona, R, Veber, G, Dharmaratne, S, Do, H, Dokova, K, Dorsey, E, Ellenbogen, R, Eskandarieh, S, Farvid, M, Fereshtehnejad, S, Fischer, F, Foreman, K, Geleijnse, J, Gillum, R, Giussani, G, Gona, P, Goulart, A, Gugnani, H, Gupta, R, Hamadeh, R, Hambisa, M, Hankey, G, Hareri, H, Havmoeller, R, Hay, S, Heydarpour, P, Hotez, P, Jakovljevic, M, Javanbakht, M, Jeemon, P, Jonas, J, Kalkonde, Y, Kandel, A, Karch, A, Kasaeian, A, Kastor, A, Keiyoro, P, Khader, Y, Khalil, I, Khan, E, Khang, Y, Tawfih, A, Khoja, A, Khubchandani, J, Kim, D, Kim, Y, Kivimaki, M, Kokubo, Y, Kosen, S, Kravchenko, M, Krishnamurthi, R, Defo, B, Kumar, G, Kumar, R, Kyu, H, Larsson, A, Lavados, P, Li, Y, Liang, X, Liben, M, Lo, W, Logroscino, G, Lotufo, P, Loy, C, Mackay, M, El Razek, H, El Razek, M, Majeed, A, Malekzadeh, R, Manhertz, T, Mantovani, L, Massano, J, Mazidi, M, Mcalinden, C, Mehata, S, Mehndiratta, M, Memish, Z, Mendoza, W, Mengistie, M, Mensah, G, Meretoja, A, Mezgebe, H, Miller, T, Mishra, S, Ibrahim, N, Mohammadi, A, Mohammed, K, Mohammed, S, Mokdad, A, Moradi-Lakeh, M, Velasquez, I, Musa, K, Naghavi, M, Ngunjiri, J, Nguyen, C, Nguyen, G, Le Nguyen, Q, Nguyen, T, Nichols, E, Ningrum, D, Nong, V, Norrving, B, Noubiap, J, Ogbo, F, Owolabi, M, Pandian, J, Petzold, M, Phillips, M, Piradov, M, Poulton, R, Pourmalek, F, Qorbani, M, Rafay, A, Rahman, M, Rai, R, Rajsic, S, Ranta, A, Rawaf, S, Renzaho, A, Rezai, M, Roshandel, G, Rubagotti, E, Sachdev, P, Safiri, S, Sahathevan, R, Sahraian, M, Samy, A, Santalucia, P, Santos, I, Sartorius, B, Satpathy, M, Sawhney, M, Saylan, M, Sepanlou, S, Shaikh, M, Shakir, R, Shamsizadeh, M, Sheth, K, Shigematsu, M, Shoman, H, Silva, D, Smith, M, Sobngwi, E, Sposato, L, Stein, D, Steiner, T, Stovner, L, Abdulkader, R, EI Szoeke, C, Tabarés-Seisdedos, R, Tanne, D, Theadom, A, Thrift, A, Tirschwell, D, Topor-Madry, R, Tran, B, Truelsen, T, Tuem, K, Ukwaja, K, Uthman, O, Varakin, Y, Vasankari, T, Venketasubramanian, N, Vlassov, V, Wadilo, F, Wakayo, T, Wallin, M, Weiderpass, E, Westerman, R, Wijeratne, T, Wiysonge, C, Woldu, M, Wolfe, C, Xavier, D, Xu, G, Yano, Y, Yimam, H, Yonemoto, N, Yu, C, Zaidi, Z, El Sayed Zaki, M, Zunt, J, Murray, C, Vos, T, Feigin, VL, Abajobir, AA, Abate, KH, Abdulle, AM, Abera, SF, Abyu, GY, Ahmed, MB, Aichour, AN, Aichour, MTE, Akinyemi, RO, Amare, AT, Asgedom, SW, Atey, TM, Avokpaho, GA, Barker-Collo, SL, Bennett, DA, Bensenor, IM, Betsu, BD, Birlik, SM, Boneya, DJ, Bulto, LNB, Castañeda-Orjuela, CA, Chitheer, AA, Veber, GA, Dharmaratne, SD, Do, HP, Dorsey, ER, Ellenbogen, RG, Farvid, MS, Fereshtehnejad, SM, Foreman, KJ, Geleijnse, JM, Gillum, RF, Gona, PN, Goulart, AC, Gugnani, HC, Hamadeh, RR, Hankey, GJ, Hareri, HA, Hay, SI, Hotez, PJ, Jakovljevic, MMB, Jonas, JB, Keiyoro, PN, Khader, YS, Khalil, IA, Khan, EA, Khang, YH, Kim, YJ, Krishnamurthi, RV, Defo, BK, Kumar, GA, Kyu, HH, Lavados, PM, Liben, ML, Lo, WD, Lotufo, PA, Loy, CT, Mackay, MT, El Razek, HMA, El Razek, MMA, Mantovani, LG, McAlinden, C, Mehndiratta, MM, Memish, ZA, Mengistie, MA, Mensah, GA, Mezgebe, HB, Miller, TR, Mishra, SR, Ibrahim, NM, Mohammed, KE, Mokdad, AH, Velasquez, IM, Musa, KI, Ngunjiri, JW, Nguyen, CT, Nguyen, TH, Ningrum, DNA, Nong, VM, Noubiap, JJN, Ogbo, FA, Owolabi, MO, Pandian, JD, Phillips, MR, Piradov, MA, Poulton, RG, Rahman, MH, Rai, RK, Renzaho, AMN, Rezai, MS, Sahraian, MA, Samy, AM, Santos, IS, Saylan, MI, Sepanlou, SG, Shaikh, MA, Sheth, KN, Silva, DAS, Sposato, LA, Stein, DJ, Steiner, TJ, Stovner, LJ, Abdulkader, RS, Theadom, AM, Thrift, AG, Tirschwell, DL, Tran, BX, Tuem, KB, Ukwaja, KN, Uthman, OA, Varakin, YY, Vlassov, VV, Wallin, MT, Wiysonge, CS, Woldu, MA, Wolfe, CDA, Yimam, HH, Zunt, JR, Murray, CJL, Feigin, V, Abajobir, A, Abate, K, Abd-Allah, F, Abdulle, A, Abera, S, Abyu, G, Ahmed, M, Aichour, A, Aichour, I, Aichour, M, Akinyemi, R, Alabed, S, Al-Raddadi, R, Alvis-Guzman, N, Amare, A, Ansari, H, Anwari, P, Ärnlöv, J, Asayesh, H, Asgedom, S, Atey, T, Avila-Burgos, L, Frinel, E, Avokpaho, G, Barac, A, Barboza, M, Barker-Collo, S, Bärnighausen, T, Bedi, N, Beghi, E, Bennett, D, Bensenor, I, Berhane, A, Betsu, B, Bhaumik, S, Birlik, S, Biryukov, S, Boneya, D, Bulto, L, Carabin, H, Casey, D, Castañeda-Orjuela, C, Catalá-López, F, Chen, H, Chitheer, A, Chowdhury, R, Christensen, H, Dandona, L, Dandona, R, Veber, G, Dharmaratne, S, Do, H, Dokova, K, Dorsey, E, Ellenbogen, R, Eskandarieh, S, Farvid, M, Fereshtehnejad, S, Fischer, F, Foreman, K, Geleijnse, J, Gillum, R, Giussani, G, Gona, P, Goulart, A, Gugnani, H, Gupta, R, Hamadeh, R, Hambisa, M, Hankey, G, Hareri, H, Havmoeller, R, Hay, S, Heydarpour, P, Hotez, P, Jakovljevic, M, Javanbakht, M, Jeemon, P, Jonas, J, Kalkonde, Y, Kandel, A, Karch, A, Kasaeian, A, Kastor, A, Keiyoro, P, Khader, Y, Khalil, I, Khan, E, Khang, Y, Tawfih, A, Khoja, A, Khubchandani, J, Kim, D, Kim, Y, Kivimaki, M, Kokubo, Y, Kosen, S, Kravchenko, M, Krishnamurthi, R, Defo, B, Kumar, G, Kumar, R, Kyu, H, Larsson, A, Lavados, P, Li, Y, Liang, X, Liben, M, Lo, W, Logroscino, G, Lotufo, P, Loy, C, Mackay, M, El Razek, H, El Razek, M, Majeed, A, Malekzadeh, R, Manhertz, T, Mantovani, L, Massano, J, Mazidi, M, Mcalinden, C, Mehata, S, Mehndiratta, M, Memish, Z, Mendoza, W, Mengistie, M, Mensah, G, Meretoja, A, Mezgebe, H, Miller, T, Mishra, S, Ibrahim, N, Mohammadi, A, Mohammed, K, Mohammed, S, Mokdad, A, Moradi-Lakeh, M, Velasquez, I, Musa, K, Naghavi, M, Ngunjiri, J, Nguyen, C, Nguyen, G, Le Nguyen, Q, Nguyen, T, Nichols, E, Ningrum, D, Nong, V, Norrving, B, Noubiap, J, Ogbo, F, Owolabi, M, Pandian, J, Petzold, M, Phillips, M, Piradov, M, Poulton, R, Pourmalek, F, Qorbani, M, Rafay, A, Rahman, M, Rai, R, Rajsic, S, Ranta, A, Rawaf, S, Renzaho, A, Rezai, M, Roshandel, G, Rubagotti, E, Sachdev, P, Safiri, S, Sahathevan, R, Sahraian, M, Samy, A, Santalucia, P, Santos, I, Sartorius, B, Satpathy, M, Sawhney, M, Saylan, M, Sepanlou, S, Shaikh, M, Shakir, R, Shamsizadeh, M, Sheth, K, Shigematsu, M, Shoman, H, Silva, D, Smith, M, Sobngwi, E, Sposato, L, Stein, D, Steiner, T, Stovner, L, Abdulkader, R, EI Szoeke, C, Tabarés-Seisdedos, R, Tanne, D, Theadom, A, Thrift, A, Tirschwell, D, Topor-Madry, R, Tran, B, Truelsen, T, Tuem, K, Ukwaja, K, Uthman, O, Varakin, Y, Vasankari, T, Venketasubramanian, N, Vlassov, V, Wadilo, F, Wakayo, T, Wallin, M, Weiderpass, E, Westerman, R, Wijeratne, T, Wiysonge, C, Woldu, M, Wolfe, C, Xavier, D, Xu, G, Yano, Y, Yimam, H, Yonemoto, N, Yu, C, Zaidi, Z, El Sayed Zaki, M, Zunt, J, Murray, C, Vos, T, Feigin, VL, Abajobir, AA, Abate, KH, Abdulle, AM, Abera, SF, Abyu, GY, Ahmed, MB, Aichour, AN, Aichour, MTE, Akinyemi, RO, Amare, AT, Asgedom, SW, Atey, TM, Avokpaho, GA, Barker-Collo, SL, Bennett, DA, Bensenor, IM, Betsu, BD, Birlik, SM, Boneya, DJ, Bulto, LNB, Castañeda-Orjuela, CA, Chitheer, AA, Veber, GA, Dharmaratne, SD, Do, HP, Dorsey, ER, Ellenbogen, RG, Farvid, MS, Fereshtehnejad, SM, Foreman, KJ, Geleijnse, JM, Gillum, RF, Gona, PN, Goulart, AC, Gugnani, HC, Hamadeh, RR, Hankey, GJ, Hareri, HA, Hay, SI, Hotez, PJ, Jakovljevic, MMB, Jonas, JB, Keiyoro, PN, Khader, YS, Khalil, IA, Khan, EA, Khang, YH, Kim, YJ, Krishnamurthi, RV, Defo, BK, Kumar, GA, Kyu, HH, Lavados, PM, Liben, ML, Lo, WD, Lotufo, PA, Loy, CT, Mackay, MT, El Razek, HMA, El Razek, MMA, Mantovani, LG, McAlinden, C, Mehndiratta, MM, Memish, ZA, Mengistie, MA, Mensah, GA, Mezgebe, HB, Miller, TR, Mishra, SR, Ibrahim, NM, Mohammed, KE, Mokdad, AH, Velasquez, IM, Musa, KI, Ngunjiri, JW, Nguyen, CT, Nguyen, TH, Ningrum, DNA, Nong, VM, Noubiap, JJN, Ogbo, FA, Owolabi, MO, Pandian, JD, Phillips, MR, Piradov, MA, Poulton, RG, Rahman, MH, Rai, RK, Renzaho, AMN, Rezai, MS, Sahraian, MA, Samy, AM, Santos, IS, Saylan, MI, Sepanlou, SG, Shaikh, MA, Sheth, KN, Silva, DAS, Sposato, LA, Stein, DJ, Steiner, TJ, Stovner, LJ, Abdulkader, RS, Theadom, AM, Thrift, AG, Tirschwell, DL, Tran, BX, Tuem, KB, Ukwaja, KN, Uthman, OA, Varakin, YY, Vlassov, VV, Wallin, MT, Wiysonge, CS, Woldu, MA, Wolfe, CDA, Yimam, HH, Zunt, JR, and Murray, CJL
Abstract: Background Comparable data on the global and country-specific burden of neurological disorders and their trends are crucial for health-care planning and resource allocation. The Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study provides such information but does not routinely aggregate results that are of interest to clinicians specialising in neurological conditions. In this systematic analysis, we quantified the global disease burden due to neurological disorders in 2015 and its relationship with country development level. Methods We estimated global and country-specific prevalence, mortality, disability-adjusted life-years (DALYs), years of life lost (YLLs), and years lived with disability (YLDs) for various neurological disorders that in the GBD classification have been previously spread across multiple disease groupings. The more inclusive grouping of neurological disorders included stroke, meningitis, encephalitis, tetanus, Alzheimer's disease and other dementias, Parkinson's disease, epilepsy, multiple sclerosis, motor neuron disease, migraine, tension-type headache, medication overuse headache, brain and nervous system cancers, and a residual category of other neurological disorders. We also analysed results based on the Socio-demographic Index (SDI), a compound measure of income per capita, education, and fertility, to identify patterns associated with development and how countries fare against expected outcomes relative to their level of development. Findings Neurological disorders ranked as the leading cause group of DALYs in 2015 (250·7 [95% uncertainty interval (UI) 229·1 to 274·7] million, comprising 10·2% of global DALYs) and the second-leading cause group of deaths (9·4 [9·1 to 9·7] million], comprising 16·8% of global deaths). The most prevalent neurological disorders were tension-type headache (1505·9 [UI 1337·3 to 1681·6 million cases]), migraine (958·8 [872·1 to 1055·6] million), medication overuse headache (58·5 [50·8 to 67·4 mil
Published: 2017

38. Smoking prevalence and attributable disease burden in 195 countries and territories, 1990-2015: a systematic analysis from the Global Burden of Disease Study 2015

Author: Reitsma, MB, Fullman, N, Ng, M, Salama, JS, Abajobir, A, Abate, KH, Abbafati, C, Abera, SF, Abraham, B, Abyu, GY, Adebiyi, AO, Al-Aly, Z, Aleman, AV, Ali, R, Al Alkerwi, A, Allebeck, P, Al-Raddadi, RM, Amare, AT, Amberbir, A, Ammar, W, Amrock, SM, Antonio, CAT, Asayesh, H, Atnafu, NT, Azzopardi, P, Banerjee, A, Barac, A, Barrientos-Gutierrez, T, Basto-Abreu, AC, Bazargan-Hejazi, S, Bedi, N, Bell, B, Bello, AK, Bensenor, IM, Beyene, AS, Bhala, N, Biryukov, S, Bolt, K, Brenner, H, Butt, Z, Cavalleri, F, Cercy, K, Chen, H, Christopher, DJ, Ciobanu, LG, Colistro, V, Colomar, M, Cornaby, L, Dai, X, Damtew, SA, Dandona, L, Dandona, R, Dansereau, E, Davletov, K, Dayama, A, Degfie, TT, Deribew, A, Dharmaratne, SD, Dimtsu, BD, Doyle, KE, Endries, AY, Ermakov, SP, Estep, K, Faraon, EJA, Farzadfar, F, Feigin, VL, Feigl, AB, Fischer, F, Friedman, J, Ghiwot, TT, Gall, SL, Gao, W, Gillum, RF, Gold, AL, Gopalani, SV, Gotay, CC, Gupta, R, Gupta, V, Hamadeh, RR, Hankey, G, Harb, HL, Hay, SI, Horino, M, Horita, N, Hosgood, HD, Husseini, A, Ileanu, BV, Islami, F, Jiang, G, Jiang, Y, Jonas, JB, Kabir, Z, Kamal, R, Kasaeian, A, Kesavachandran, CN, Khader, YS, Khalil, I, Khang, Y-H, Khera, S, Khubchandani, J, Kim, D, Kim, YJ, Kimokoti, RW, Kinfu, Y, Knibbs, LD, Kokubo, Y, Kolte, D, Kopec, J, Kosen, S, Kotsakis, GA, Koul, PA, Koyanagi, A, Krohn, KJ, Krueger, H, Defo, BK, Bicer, BK, Kulkarni, C, Kumar, GA, Leasher, JL, Lee, A, Leinsalu, M, Li, T, Linn, S, Liu, P, Liu, S, Lo, L-T, Lopez, AD, Ma, S, Abd El Razek, HM, Majeed, A, Malekzadeh, R, Malta, DC, Manamo, WA, Martinez-Raga, J, Mekonnen, AB, Mendoza, W, Miller, TR, Mohammad, KA, Morawska, L, Musa, KI, Nagel, G, Neupane, SP, Quyen, N, Nguyen, G, Oh, I-H, Oyekale, AS, Mahesh, PA, Pana, A, Park, E-K, Patil, ST, Patton, GC, Pedro, J, Qorbani, M, Rafay, A, Rahman, M, Rai, RK, Ram, U, Ranabhat, CL, Refaat, AH, Reinig, N, Roba, HS, Rodriguez, A, Roman, Y, Roth, G, Roy, A, Sagar, R, Salomon, J, Sanabria, J, Santos, IDS, Sartorius, B, Satpathy, M, Sawhney, M, Sawyer, S, Saylan, M, Schaub, MP, Schluger, N, Schutte, AE, Sepanlou, SG, Serdar, B, Shaikh, MA, She, J, Shin, M-J, Shiri, R, Shishani, K, Shiue, I, Sigfusdottir, ID, Silverberg, JI, Singh, J, Singh, V, Slepak, EL, Soneji, S, Soriano, JB, Soshnikov, S, Sreeramareddy, CT, Stein, DJ, Stranges, S, Subart, ML, Swaminathan, S, Szoeke, CEI, Tefera, WM, Topor-Madry, R, Tran, B, Tsilimparis, N, Tymeson, H, Ukwaja, KN, Updike, R, Uthman, OA, Violante, FS, Vladimirov, SK, Vlassov, V, Vollset, SE, Vos, T, Weiderpass, E, Wen, C-P, Werdecker, A, Wilson, S, Wubshet, M, Xiao, L, Yakob, B, Yano, Y, Ye, P, Yonemoto, N, Yoon, S-J, Younis, MZ, Yu, C, Zaidi, Z, Zaki, MES, Zhang, AL, Zipkin, B, Murray, CJL, Forouzanfar, MH, Gakidou, E, Reitsma, MB, Fullman, N, Ng, M, Salama, JS, Abajobir, A, Abate, KH, Abbafati, C, Abera, SF, Abraham, B, Abyu, GY, Adebiyi, AO, Al-Aly, Z, Aleman, AV, Ali, R, Al Alkerwi, A, Allebeck, P, Al-Raddadi, RM, Amare, AT, Amberbir, A, Ammar, W, Amrock, SM, Antonio, CAT, Asayesh, H, Atnafu, NT, Azzopardi, P, Banerjee, A, Barac, A, Barrientos-Gutierrez, T, Basto-Abreu, AC, Bazargan-Hejazi, S, Bedi, N, Bell, B, Bello, AK, Bensenor, IM, Beyene, AS, Bhala, N, Biryukov, S, Bolt, K, Brenner, H, Butt, Z, Cavalleri, F, Cercy, K, Chen, H, Christopher, DJ, Ciobanu, LG, Colistro, V, Colomar, M, Cornaby, L, Dai, X, Damtew, SA, Dandona, L, Dandona, R, Dansereau, E, Davletov, K, Dayama, A, Degfie, TT, Deribew, A, Dharmaratne, SD, Dimtsu, BD, Doyle, KE, Endries, AY, Ermakov, SP, Estep, K, Faraon, EJA, Farzadfar, F, Feigin, VL, Feigl, AB, Fischer, F, Friedman, J, Ghiwot, TT, Gall, SL, Gao, W, Gillum, RF, Gold, AL, Gopalani, SV, Gotay, CC, Gupta, R, Gupta, V, Hamadeh, RR, Hankey, G, Harb, HL, Hay, SI, Horino, M, Horita, N, Hosgood, HD, Husseini, A, Ileanu, BV, Islami, F, Jiang, G, Jiang, Y, Jonas, JB, Kabir, Z, Kamal, R, Kasaeian, A, Kesavachandran, CN, Khader, YS, Khalil, I, Khang, Y-H, Khera, S, Khubchandani, J, Kim, D, Kim, YJ, Kimokoti, RW, Kinfu, Y, Knibbs, LD, Kokubo, Y, Kolte, D, Kopec, J, Kosen, S, Kotsakis, GA, Koul, PA, Koyanagi, A, Krohn, KJ, Krueger, H, Defo, BK, Bicer, BK, Kulkarni, C, Kumar, GA, Leasher, JL, Lee, A, Leinsalu, M, Li, T, Linn, S, Liu, P, Liu, S, Lo, L-T, Lopez, AD, Ma, S, Abd El Razek, HM, Majeed, A, Malekzadeh, R, Malta, DC, Manamo, WA, Martinez-Raga, J, Mekonnen, AB, Mendoza, W, Miller, TR, Mohammad, KA, Morawska, L, Musa, KI, Nagel, G, Neupane, SP, Quyen, N, Nguyen, G, Oh, I-H, Oyekale, AS, Mahesh, PA, Pana, A, Park, E-K, Patil, ST, Patton, GC, Pedro, J, Qorbani, M, Rafay, A, Rahman, M, Rai, RK, Ram, U, Ranabhat, CL, Refaat, AH, Reinig, N, Roba, HS, Rodriguez, A, Roman, Y, Roth, G, Roy, A, Sagar, R, Salomon, J, Sanabria, J, Santos, IDS, Sartorius, B, Satpathy, M, Sawhney, M, Sawyer, S, Saylan, M, Schaub, MP, Schluger, N, Schutte, AE, Sepanlou, SG, Serdar, B, Shaikh, MA, She, J, Shin, M-J, Shiri, R, Shishani, K, Shiue, I, Sigfusdottir, ID, Silverberg, JI, Singh, J, Singh, V, Slepak, EL, Soneji, S, Soriano, JB, Soshnikov, S, Sreeramareddy, CT, Stein, DJ, Stranges, S, Subart, ML, Swaminathan, S, Szoeke, CEI, Tefera, WM, Topor-Madry, R, Tran, B, Tsilimparis, N, Tymeson, H, Ukwaja, KN, Updike, R, Uthman, OA, Violante, FS, Vladimirov, SK, Vlassov, V, Vollset, SE, Vos, T, Weiderpass, E, Wen, C-P, Werdecker, A, Wilson, S, Wubshet, M, Xiao, L, Yakob, B, Yano, Y, Ye, P, Yonemoto, N, Yoon, S-J, Younis, MZ, Yu, C, Zaidi, Z, Zaki, MES, Zhang, AL, Zipkin, B, Murray, CJL, Forouzanfar, MH, and Gakidou, E
Abstract: BACKGROUND: The scale-up of tobacco control, especially after the adoption of the Framework Convention for Tobacco Control, is a major public health success story. Nonetheless, smoking remains a leading risk for early death and disability worldwide, and therefore continues to require sustained political commitment. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) offers a robust platform through which global, regional, and national progress toward achieving smoking-related targets can be assessed. METHODS: We synthesised 2818 data sources with spatiotemporal Gaussian process regression and produced estimates of daily smoking prevalence by sex, age group, and year for 195 countries and territories from 1990 to 2015. We analysed 38 risk-outcome pairs to generate estimates of smoking-attributable mortality and disease burden, as measured by disability-adjusted life-years (DALYs). We then performed a cohort analysis of smoking prevalence by birth-year cohort to better understand temporal age patterns in smoking. We also did a decomposition analysis, in which we parsed out changes in all-cause smoking-attributable DALYs due to changes in population growth, population ageing, smoking prevalence, and risk-deleted DALY rates. Finally, we explored results by level of development using the Socio-demographic Index (SDI). FINDINGS: Worldwide, the age-standardised prevalence of daily smoking was 25·0% (95% uncertainty interval [UI] 24·2-25·7) for men and 5·4% (5·1-5·7) for women, representing 28·4% (25·8-31·1) and 34·4% (29·4-38·6) reductions, respectively, since 1990. A greater percentage of countries and territories achieved significant annualised rates of decline in smoking prevalence from 1990 to 2005 than in between 2005 and 2015; however, only four countries had significant annualised increases in smoking prevalence between 2005 and 2015 (Congo [Brazzaville] and Azerbaijan for men and Kuwait and Timor-Leste for women). In 2015, 11·5% of global deaths (
Published: 2017

39. Burden of musculoskeletal disorders in the Eastern Mediterranean Region, 1990-2013: findings from the Global Burden of Disease Study 2013

Author: Moradi-Lakeh, M, Forouzanfar, MH, Vollset, SE, El Bcheraoui, C, Daoud, F, Afshin, A, Charara, R, Khalil, I, Higashi, H, El Razek, MMA, Kiadaliri, AA, Alam, K, Akseer, N, Al-Hamad, N, Ali, R, AlMazroa, MA, Alomari, MA, Al-Rabeeah, AA, Alsharif, U, Altirkawi, KA, Atique, S, Badawi, A, Barrero, LH, Basulaiman, M, Bazargan-Hejazi, S, Bedi, N, Bensenor, IM, Buchbinder, R, Danawi, H, Dharmaratne, SD, Zannad, F, Farvid, MS, Fereshtehnejad, S-M, Farzadfar, F, Fischer, F, Gupta, R, Hamadeh, RR, Hamidi, S, Horino, M, Hoy, DG, Hsairi, M, Husseini, A, Javanbakht, M, Jonas, JB, Kasaeian, A, Khan, EA, Khubchandani, J, Knudsen, AK, Kopec, JA, Lunevicius, R, El Razek, HMA, Majeed, A, Malekzadeh, R, Mate, K, Mehari, A, Meltzer, M, Memish, ZA, Mirarefin, M, Mohammed, S, Naheed, A, Obermeyer, CM, Oh, I-H, Park, E-K, Peprah, EK, Pourmalek, F, Qorbani, M, Rafay, A, Rahimi-Movaghar, V, Shiri, R, Rahman, SU, Rai, RK, Rana, SM, Sepanlou, SG, Shaikh, MA, Shiue, I, Sibai, AM, Silva, DAS, Singh, JA, Skogen, JC, Terkawi, AS, Ukwaja, KN, Westerman, R, Yonemoto, N, Yoon, S-J, Younis, MZ, Zaidi, Z, Zaki, MES, Lim, SS, Wang, H, Vos, T, Naghavi, M, Lopez, AD, Murray, CJL, Mokdad, AH, Moradi-Lakeh, M, Forouzanfar, MH, Vollset, SE, El Bcheraoui, C, Daoud, F, Afshin, A, Charara, R, Khalil, I, Higashi, H, El Razek, MMA, Kiadaliri, AA, Alam, K, Akseer, N, Al-Hamad, N, Ali, R, AlMazroa, MA, Alomari, MA, Al-Rabeeah, AA, Alsharif, U, Altirkawi, KA, Atique, S, Badawi, A, Barrero, LH, Basulaiman, M, Bazargan-Hejazi, S, Bedi, N, Bensenor, IM, Buchbinder, R, Danawi, H, Dharmaratne, SD, Zannad, F, Farvid, MS, Fereshtehnejad, S-M, Farzadfar, F, Fischer, F, Gupta, R, Hamadeh, RR, Hamidi, S, Horino, M, Hoy, DG, Hsairi, M, Husseini, A, Javanbakht, M, Jonas, JB, Kasaeian, A, Khan, EA, Khubchandani, J, Knudsen, AK, Kopec, JA, Lunevicius, R, El Razek, HMA, Majeed, A, Malekzadeh, R, Mate, K, Mehari, A, Meltzer, M, Memish, ZA, Mirarefin, M, Mohammed, S, Naheed, A, Obermeyer, CM, Oh, I-H, Park, E-K, Peprah, EK, Pourmalek, F, Qorbani, M, Rafay, A, Rahimi-Movaghar, V, Shiri, R, Rahman, SU, Rai, RK, Rana, SM, Sepanlou, SG, Shaikh, MA, Shiue, I, Sibai, AM, Silva, DAS, Singh, JA, Skogen, JC, Terkawi, AS, Ukwaja, KN, Westerman, R, Yonemoto, N, Yoon, S-J, Younis, MZ, Zaidi, Z, Zaki, MES, Lim, SS, Wang, H, Vos, T, Naghavi, M, Lopez, AD, Murray, CJL, and Mokdad, AH
Abstract: OBJECTIVES: We used findings from the Global Burden of Disease Study 2013 to report the burden of musculoskeletal disorders in the Eastern Mediterranean Region (EMR). METHODS: The burden of musculoskeletal disorders was calculated for the EMR's 22 countries between 1990 and 2013. A systematic analysis was performed on mortality and morbidity data to estimate prevalence, death, years of live lost, years lived with disability and disability-adjusted life years (DALYs). RESULTS: For musculoskeletal disorders, the crude DALYs rate per 100 000 increased from 1297.1 (95% uncertainty interval (UI) 924.3-1703.4) in 1990 to 1606.0 (95% UI 1141.2-2130.4) in 2013. During 1990-2013, the total DALYs of musculoskeletal disorders increased by 105.2% in the EMR compared with a 58.0% increase in the rest of the world. The burden of musculoskeletal disorders as a proportion of total DALYs increased from 2.4% (95% UI 1.7-3.0) in 1990 to 4.7% (95% UI 3.6-5.8) in 2013. The range of point prevalence (per 1000) among the EMR countries was 28.2-136.0 for low back pain, 27.3-49.7 for neck pain, 9.7-37.3 for osteoarthritis (OA), 0.6-2.2 for rheumatoid arthritis and 0.1-0.8 for gout. Low back pain and neck pain had the highest burden in EMR countries. CONCLUSIONS: This study shows a high burden of musculoskeletal disorders, with a faster increase in EMR compared with the rest of the world. The reasons for this faster increase need to be explored. Our findings call for incorporating prevention and control programmes that should include improving health data, addressing risk factors, providing evidence-based care and community programmes to increase awareness.
Published: 2017

40. Global, Regional, and National Burden of Cardiovascular Diseases for 10 Causes, 1990 to 2015

Author: Roth, GA, Johnson, C, Abajobir, A, Abd-Allah, F, Abera, SF, Abyu, G, Ahmed, M, Aksut, B, Alam, T, Alam, K, Alla, F, Alvis-Guzman, N, Amrock, S, Ansari, H, Arnlov, J, Asayesh, H, Atey, TM, Avila-Burgos, L, Awasthi, A, Banerjee, A, Barac, A, Barnighausen, T, Barregard, L, Bedi, N, Ketema, EB, Bennett, D, Berhe, G, Bhutta, Z, Bitew, S, Carapetis, J, Carrero, JJ, Malta, DC, Andres Castaneda-Orjuela, C, Castillo-Rivas, J, Catala-Lopez, F, Choi, J-Y, Christensen, H, Cirillo, M, Cooper, L, Criqui, M, Cundiff, D, Damasceno, A, Dandona, L, Dandona, R, Davletov, K, Dharmaratne, S, Dorairaj, P, Dubey, M, Ehrenkranz, R, Zaki, MES, Faraon, EJA, Esteghamati, A, Farid, T, Farvid, M, Feigin, V, Ding, EL, Fowkes, G, Gebrehiwot, T, Gillum, R, Gold, A, Gona, P, Gupta, R, Habtewold, TD, Hafezi-Nejad, N, Hailu, T, Hailu, GB, Hankey, G, Hassen, HY, Abate, KH, Havmoeller, R, Hay, SI, Horino, M, Hotez, PJ, Jacobsen, K, James, S, Javanbakht, M, Jeemon, P, John, D, Jonas, J, Kalkonde, Y, Karimkhani, C, Kasaeian, A, Khader, Y, Khan, A, Khang, Y-H, Khera, S, Khoja, AT, Khubchandani, J, Kim, D, Kolte, D, Kosen, S, Krohn, KJ, Kumar, GA, Kwan, GF, Lal, DK, Larsson, A, Linn, S, Lopez, A, Lotufo, PA, Abd El Razek, HM, Malekzadeh, R, Mazidi, M, Meier, T, Meles, KG, Mensah, G, Meretoja, A, Mezgebe, H, Miller, T, Mirrakhimov, E, Mohammed, S, Moran, AE, Musa, KI, Narula, J, Neal, B, Ngalesoni, F, Grant, N, Obermeyer, CM, Owolabi, M, Patton, G, Pedro, J, Qato, D, Qorbani, M, Rahimi, K, Rai, RK, Rawaf, S, Ribeiro, A, Safiri, S, Salomon, JA, Santos, I, Milicevic, MS, Sartorius, B, Schutte, A, Sepanlou, S, Shaikh, MA, Shin, M-J, Shishehbor, M, Shore, H, Santos Silva, DA, Sobngwi, E, Stranges, S, Swaminathan, S, Tabares-Seisdedos, R, Atnafu, NT, Tesfay, F, Thakur, JS, Thrift, A, Topor-Madry, R, Truelsen, T, Tyrovolas, S, Ukwaja, KN, Uthman, O, Vasankari, T, Vlassov, V, Vollset, SE, Wakayo, T, Watkins, D, Weintraub, R, Werdecker, A, Westerman, R, Wiysonge, CS, Wolfe, C, Workicho, A, Xu, G, Yano, Y, Yip, P, Yonemoto, N, Younis, M, Yu, C, Vos, T, Naghavi, M, Murray, C, Roth, GA, Johnson, C, Abajobir, A, Abd-Allah, F, Abera, SF, Abyu, G, Ahmed, M, Aksut, B, Alam, T, Alam, K, Alla, F, Alvis-Guzman, N, Amrock, S, Ansari, H, Arnlov, J, Asayesh, H, Atey, TM, Avila-Burgos, L, Awasthi, A, Banerjee, A, Barac, A, Barnighausen, T, Barregard, L, Bedi, N, Ketema, EB, Bennett, D, Berhe, G, Bhutta, Z, Bitew, S, Carapetis, J, Carrero, JJ, Malta, DC, Andres Castaneda-Orjuela, C, Castillo-Rivas, J, Catala-Lopez, F, Choi, J-Y, Christensen, H, Cirillo, M, Cooper, L, Criqui, M, Cundiff, D, Damasceno, A, Dandona, L, Dandona, R, Davletov, K, Dharmaratne, S, Dorairaj, P, Dubey, M, Ehrenkranz, R, Zaki, MES, Faraon, EJA, Esteghamati, A, Farid, T, Farvid, M, Feigin, V, Ding, EL, Fowkes, G, Gebrehiwot, T, Gillum, R, Gold, A, Gona, P, Gupta, R, Habtewold, TD, Hafezi-Nejad, N, Hailu, T, Hailu, GB, Hankey, G, Hassen, HY, Abate, KH, Havmoeller, R, Hay, SI, Horino, M, Hotez, PJ, Jacobsen, K, James, S, Javanbakht, M, Jeemon, P, John, D, Jonas, J, Kalkonde, Y, Karimkhani, C, Kasaeian, A, Khader, Y, Khan, A, Khang, Y-H, Khera, S, Khoja, AT, Khubchandani, J, Kim, D, Kolte, D, Kosen, S, Krohn, KJ, Kumar, GA, Kwan, GF, Lal, DK, Larsson, A, Linn, S, Lopez, A, Lotufo, PA, Abd El Razek, HM, Malekzadeh, R, Mazidi, M, Meier, T, Meles, KG, Mensah, G, Meretoja, A, Mezgebe, H, Miller, T, Mirrakhimov, E, Mohammed, S, Moran, AE, Musa, KI, Narula, J, Neal, B, Ngalesoni, F, Grant, N, Obermeyer, CM, Owolabi, M, Patton, G, Pedro, J, Qato, D, Qorbani, M, Rahimi, K, Rai, RK, Rawaf, S, Ribeiro, A, Safiri, S, Salomon, JA, Santos, I, Milicevic, MS, Sartorius, B, Schutte, A, Sepanlou, S, Shaikh, MA, Shin, M-J, Shishehbor, M, Shore, H, Santos Silva, DA, Sobngwi, E, Stranges, S, Swaminathan, S, Tabares-Seisdedos, R, Atnafu, NT, Tesfay, F, Thakur, JS, Thrift, A, Topor-Madry, R, Truelsen, T, Tyrovolas, S, Ukwaja, KN, Uthman, O, Vasankari, T, Vlassov, V, Vollset, SE, Wakayo, T, Watkins, D, Weintraub, R, Werdecker, A, Westerman, R, Wiysonge, CS, Wolfe, C, Workicho, A, Xu, G, Yano, Y, Yip, P, Yonemoto, N, Younis, M, Yu, C, Vos, T, Naghavi, M, and Murray, C
Abstract: BACKGROUND: The burden of cardiovascular diseases (CVDs) remains unclear in many regions of the world. OBJECTIVES: The GBD (Global Burden of Disease) 2015 study integrated data on disease incidence, prevalence, and mortality to produce consistent, up-to-date estimates for cardiovascular burden. METHODS: CVD mortality was estimated from vital registration and verbal autopsy data. CVD prevalence was estimated using modeling software and data from health surveys, prospective cohorts, health system administrative data, and registries. Years lived with disability (YLD) were estimated by multiplying prevalence by disability weights. Years of life lost (YLL) were estimated by multiplying age-specific CVD deaths by a reference life expectancy. A sociodemographic index (SDI) was created for each location based on income per capita, educational attainment, and fertility. RESULTS: In 2015, there were an estimated 422.7 million cases of CVD (95% uncertainty interval: 415.53 to 427.87 million cases) and 17.92 million CVD deaths (95% uncertainty interval: 17.59 to 18.28 million CVD deaths). Declines in the age-standardized CVD death rate occurred between 1990 and 2015 in all high-income and some middle-income countries. Ischemic heart disease was the leading cause of CVD health lost globally, as well as in each world region, followed by stroke. As SDI increased beyond 0.25, the highest CVD mortality shifted from women to men. CVD mortality decreased sharply for both sexes in countries with an SDI >0.75. CONCLUSIONS: CVDs remain a major cause of health loss for all regions of the world. Sociodemographic change over the past 25 years has been associated with dramatic declines in CVD in regions with very high SDI, but only a gradual decrease or no change in most regions. Future updates of the GBD study can be used to guide policymakers who are focused on reducing the overall burden of noncommunicable disease and achieving specific global health targets for CVD.
Published: 2017

41. Global, regional, and national deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015

Author: Soriano, JB, Abajobir, AA, Abate, KH, Abera, SF, Agrawal, A, Ahmed, MB, Aichour, AN, Aichour, I, Aichour, MTE, Alam, K, Alam, N, Alkaabi, JM, Al-Maskari, F, Alvis-Guzman, N, Amberbir, A, Amoako, YA, Ansha, MG, Anto, JM, Asayesh, H, Atey, TM, Avokpaho, EFGA, Barac, A, Basu, S, Bedi, N, Bensenor, IM, Berhane, A, Beyene, AS, Bhutta, ZA, Biryukov, S, Boneya, DJ, Brauer, M, Carpenter, DO, Casey, D, Christopher, DJ, Dandona, L, Dandona, R, Dharmaratne, SD, Huyen, PD, Fischer, F, Geleto, A, Ghoshal, AG, Gillum, RF, Ginawi, IAM, Gupta, V, Hay, SI, Hedayati, MT, Horita, N, Hosgood, HD, Jakovljevic, MMB, James, SL, Jonas, JB, Kasaeian, A, Khader, YS, Khalil, IA, Khan, EA, Khang, Y-H, Khubchandani, J, Knibbs, LD, Kosen, S, Koul, PA, Kumar, GA, Leshargie, CT, Liang, X, Abd El Razek, HM, Majeed, A, Malta, DC, Manhertz, T, Marquez, N, Mehari, A, Mensah, GA, Miller, TR, Mohammad, KA, Mohammed, KE, Mohammed, S, Mokdad, AH, Naghavi, M, Cuong, TN, Nguyen, G, Quyen, LN, Trang, HN, Ningrum, DNA, Vuong, MN, Obi, JI, Odeyemi, YE, Ogbo, FA, Oren, E, Mahesh, PA, Park, E-K, Patton, GC, Paulson, K, Qorbani, M, Quansah, R, Rafay, A, Rahman, MHU, Rai, RK, Rawaf, S, Reinig, N, Safiri, S, Sarmiento-Suarez, R, Sartorius, B, Savic, M, Sawhney, M, Shigematsu, M, Smith, M, Tadese, F, Thurston, GD, Topor-Madry, R, Tran, BX, Ukwaja, KN, van Boven, JFM, Vlassov, VV, Vollset, SE, Wan, X, Werdecker, A, Hanson, SW, Yano, Y, Yimam, HH, Yonemoto, N, Yu, C, Zaidi, Z, Zaki, MES, Murray, CJL, Vos, T, Soriano, JB, Abajobir, AA, Abate, KH, Abera, SF, Agrawal, A, Ahmed, MB, Aichour, AN, Aichour, I, Aichour, MTE, Alam, K, Alam, N, Alkaabi, JM, Al-Maskari, F, Alvis-Guzman, N, Amberbir, A, Amoako, YA, Ansha, MG, Anto, JM, Asayesh, H, Atey, TM, Avokpaho, EFGA, Barac, A, Basu, S, Bedi, N, Bensenor, IM, Berhane, A, Beyene, AS, Bhutta, ZA, Biryukov, S, Boneya, DJ, Brauer, M, Carpenter, DO, Casey, D, Christopher, DJ, Dandona, L, Dandona, R, Dharmaratne, SD, Huyen, PD, Fischer, F, Geleto, A, Ghoshal, AG, Gillum, RF, Ginawi, IAM, Gupta, V, Hay, SI, Hedayati, MT, Horita, N, Hosgood, HD, Jakovljevic, MMB, James, SL, Jonas, JB, Kasaeian, A, Khader, YS, Khalil, IA, Khan, EA, Khang, Y-H, Khubchandani, J, Knibbs, LD, Kosen, S, Koul, PA, Kumar, GA, Leshargie, CT, Liang, X, Abd El Razek, HM, Majeed, A, Malta, DC, Manhertz, T, Marquez, N, Mehari, A, Mensah, GA, Miller, TR, Mohammad, KA, Mohammed, KE, Mohammed, S, Mokdad, AH, Naghavi, M, Cuong, TN, Nguyen, G, Quyen, LN, Trang, HN, Ningrum, DNA, Vuong, MN, Obi, JI, Odeyemi, YE, Ogbo, FA, Oren, E, Mahesh, PA, Park, E-K, Patton, GC, Paulson, K, Qorbani, M, Quansah, R, Rafay, A, Rahman, MHU, Rai, RK, Rawaf, S, Reinig, N, Safiri, S, Sarmiento-Suarez, R, Sartorius, B, Savic, M, Sawhney, M, Shigematsu, M, Smith, M, Tadese, F, Thurston, GD, Topor-Madry, R, Tran, BX, Ukwaja, KN, van Boven, JFM, Vlassov, VV, Vollset, SE, Wan, X, Werdecker, A, Hanson, SW, Yano, Y, Yimam, HH, Yonemoto, N, Yu, C, Zaidi, Z, Zaki, MES, Murray, CJL, and Vos, T
Abstract: BACKGROUND: Chronic obstructive pulmonary disease (COPD) and asthma are common diseases with a heterogeneous distribution worldwide. Here, we present methods and disease and risk estimates for COPD and asthma from the Global Burden of Diseases, Injuries, and Risk Factors (GBD) 2015 study. The GBD study provides annual updates on estimates of deaths, prevalence, and disability-adjusted life years (DALYs), a summary measure of fatal and non-fatal disease outcomes, for over 300 diseases and injuries, for 188 countries from 1990 to the most recent year. METHODS: We estimated numbers of deaths due to COPD and asthma using the GBD Cause of Death Ensemble modelling (CODEm) tool. First, we analysed data from vital registration and verbal autopsy for the aggregate category of all chronic respiratory diseases. Subsequently, models were run for asthma and COPD relying on covariates to predict rates in countries that have incomplete or no vital registration data. Disease estimates for COPD and asthma were based on systematic reviews of published papers, unpublished reports, surveys, and health service encounter data from the USA. We used the Global Initiative of Chronic Obstructive Lung Disease spirometry-based definition as the reference for COPD and a reported diagnosis of asthma with current wheeze as the definition of asthma. We used a Bayesian meta-regression tool, DisMod-MR 2.1, to derive estimates of prevalence and incidence. We estimated population-attributable fractions for risk factors for COPD and asthma from exposure data, relative risks, and a theoretical minimum exposure level. Results were stratified by Socio-demographic Index (SDI), a composite measure of income per capita, mean years of education over the age of 15 years, and total fertility rate. FINDINGS: In 2015, 3·2 million people (95% uncertainty interval [UI] 3·1 million to 3·3 million) died from COPD worldwide, an increase of 11·6% (95% UI 5·3 to 19·8) compared with 1990. There was a decrease in age-stan
Published: 2017

42. Estimates of global, regional, and national incidence, prevalence, and mortality of HIV, 1980-2015 : the Global Burden of Disease Study 2015

Author: GBD 2015 HIV Collaborators, Wang, H, Wolock, TM, Carter, A, Nguyen, G, Kyu, HH, Gakidou, E, Hay, SI, Mills, EJ, Trickey, A, Msemburi, W, Coates, MM, Mooney, MD, Fraser, MS, Sligar, A, Salomon, J, Larson, HJ, Friedman, J, Abajobir, AA, Abate, KH, Abbas, KM, Razek, MM, Abd-Allah, F, Abdulle, AM, Abera, SF, Abubakar, I, Abu-Raddad, LJ, Abu-Rmeileh, NM, Abyu, GY, Adebiyi, AO, Adedeji, IA, Adelekan, AL, Adofo, K, Adou, AK, Ajala, ON, Akinyemiju, TF, Akseer, N, Lami, FH, Al-Aly, Z, Alam, K, Alam, NK, Alasfoor, D, Aldhahri, SF, Aldridge, RW, Alegretti, MA, Aleman, AV, Alemu, ZA, Alfonso-Cristancho, R, Ali, R, Alkerwi, A, Alla, F, Mohammad, R, Al-Raddadi, S, Alsharif, U, Alvarez, E, Alvis-Guzman, N, Amare, AT, Amberbir, A, Amegah, AK, Ammar, W, Amrock, SM, Antonio, CA, Anwari, P, Ärnlöv, J, Artaman, A, Asayesh, H, Asghar, RJ, Assadi, R, Atique, S, Atkins, LS, Avokpaho, EF, Awasthi, A, Quintanilla, BP, Bacha, U, Badawi, A, Barac, A, Bärnighausen, T, Basu, A, Bayou, TA, Bayou, YT, Bazargan-Hejazi, S, Beardsley, J, Bedi, N, Bennett, DA, Bensenor, IM, Betsu, BD, Beyene, AS, Bhatia, E, Bhutta, ZA, Biadgilign, S, Bikbov, B, Birlik, SM, Bisanzio, D, Brainin, M, Brazinova, A, Breitborde, NJ, Brown, A, Burch, M, Butt, ZA, Campuzano, JC, Cárdenas, R, Carrero, JJ, Castañeda-Orjuela, CA, Rivas, JC, Catalá-López, F, Chang, HY, Chang, JC, Chavan, L, Chen, W, Chiang, PP, Chibalabala, M, Chisumpa, VH, Choi, JY, Christopher, DJ, Ciobanu, LG, Cooper, C, Dahiru, T, Damtew, SA, Dandona, L, Dandona, R, Das Neves, J, De Jager, P, De Leo, D, Degenhardt, L, Dellavalle, RP, Deribe, K, Deribew, A, Des Jarlais, DC, Dharmaratne, SD, Ding, EL, Doshi, PP, Driscoll, TR, Dubey, M, Elshrek, YM, Elyazar, I, Endries, AY, Ermakov, SP, Eshrati, B, Esteghamati, A, Faghmous, ID, Farinha, CS, Faro, A, Farvid, MS, Farzadfar, F, Fereshtehnejad, SM, Fernandes, JC, Fischer, F, Fitchett, JR, Foigt, N, Fullman, N, Fürst, T, Gankpé, FG, Gebre, T, Gebremedhin, AT, Gebru, AA, Geleijnse, JM, Gessner, BD, Gething, PW, Ghiwot, TT, Giroud, M, Gishu, MD, Glaser, E, Goenka, S, Goodridge, A, Gopalani, SV, Goto, A, Gugnani, HC, Guimaraes, MD, Gupta, R, Gupta, V, Haagsma, J, Hafezi-Nejad, N, Hagan, H, Hailu, GB, Hamadeh, RR, Hamidi, S, Hammami, M, Hankey, GJ, Hao, Y, Harb, HL, Harikrishnan, S, Haro, JM, Harun, KM, Havmoeller, R, Hedayati, MT, Heredia-Pi, IB, Hoek, HW, Horino, M, Horita, N, Hosgood, HD, Hoy, DG, Hsairi, M, Hu, G, Huang, H, Huang, JJ, Iburg, KM, Idrisov, BT, Innos, K, Iyer, VJ, Jacobsen, KH, Jahanmehr, N, Jakovljevic, MB, Javanbakht, M, Jayatilleke, AU, Jeemon, P, Jha, V, Jiang, G, Jiang, Y, Jibat, T, Jonas, JB, Kabir, Z, Kamal, R, Kan, H, Karch, A, Karema, CK, Karletsos, D, Kasaeian, A, Kaul, A, Kawakami, N, Kayibanda, JF, Keiyoro, PN, Kemp, AH, Kengne, AP, Kesavachandran, CN, Khader, YS, Khalil, I, Khan, AR, Khan, EA, Khang, YH, Khubchandani, J, Kim, YJ, Kinfu, Y, Kivipelto, M, Kokubo, Y, Kosen, S, Koul, PA, Koyanagi, A, Defo, BK, Bicer, BK, Kulkarni, VS, Kumar, GA, Lal, DK, Lam, H, Lam, JO, Langan, SM, Lansingh, VC, Larsson, A, Leigh, J, Leung, R, Li, Y, Lim, SS, Lipshultz, SE, Liu, S, Lloyd, BK, Logroscino, G, Lotufo, PA, Lunevicius, R, Razek, HM, Mahdavi, M, Majdan, M, Majeed, A, Makhlouf, C, Malekzadeh, R, Mapoma, CC, Marcenes, W, Martinez-Raga, J, Marzan, MB, Masiye, F, Mason-Jones, AJ, Mayosi, BM, McKee, M, Meaney, PA, Mehndiratta, MM, Mekonnen, AB, Melaku, YA, Memiah, P, Memish, ZA, Mendoza, W, Meretoja, A, Meretoja, TJ, Mhimbira, FA, Miller, TR, Mikesell, J, Mirarefin, M, Mohammad, KA, Mohammed, S, Mokdad, AH, Monasta, L, Moradi-Lakeh, M, Mori, R, Mueller, UO, Murimira, B, Murthy, GV, Naheed, A, Naldi, L, Nangia, V, Nash, D, Nawaz, H, Nejjari, C, Ngalesoni, FN, De Dieu Ngirabega, J, Nguyen, QL, Nisar, MI, Norheim, OF, Norman, RE, Nyakarahuka, L, Ogbo, FA, Oh, IH, Ojelabi, FA, Olusanya, BO, Olusanya, JO, Opio, JN, Oren, E, Ota, E, Padukudru, MA, Park, HY, Park, JH, Patil, ST, Patten, SB, Paul, VK, Pearson, K, Peprah, EK, Pereira, CC, Perico, N, Pesudovs, K, Petzold, M, Phillips, MR, Pillay, JD, Plass, D, Polinder, S, Pourmalek, F, Prokop, DM, Qorbani, M, Rafay, A, Rahimi, K, Rahimi-Movaghar, V, Rahman, M, Rahman, MH, Rahman, SU, Rai, RK, Rajsic, S, Ram, U, Rana, SM, Rao, PV, Remuzzi, G, Rojas-Rueda, D, Ronfani, L, Roshandel, G, Roy, A, Ruhago, GM, Saeedi, MY, Sagar, R, Saleh, MM, Sanabria, JR, Santos, IS, Sarmiento-Suarez, R, Sartorius, B, Sawhney, M, Schutte, AE, Schwebel, DC, Seedat, S, Sepanlou, SG, Servan-Mori, EE, Shaikh, MA, Sharma, R, She, J, Sheikhbahaei, S, Shen, J, Shibuya, K, Shin, HH, Sigfusdottir, ID, Silpakit, N, Silva, DA, Silveira, DG, Simard, EP, Sindi, S, Singh, JA, Singh, OP, Singh, PK, Skirbekk, V, Sliwa, K, Soneji, S, Sorensen, RJ, Soriano, JB, Soti, DO, Sreeramareddy, CT, Stathopoulou, V, Steel, N, Sunguya, BF, Swaminathan, S, Sykes, BL, Tabarés-Seisdedos, R, Talongwa, RT, Tavakkoli, M, Taye, B, Tedla, BA, Tekle, T, Shifa, GT, Temesgen, AM, Terkawi, AS, Tesfay, FH, Tessema, GA, Thapa, K, Thomson, AJ, Thorne-Lyman, AL, Tobe-Gai, R, Topor-Madry, R, Towbin, JA, Tran, BX, Dimbuene, ZT, Tsilimparis, N, Tura, AK, Ukwaja, KN, Uneke, CJ, Uthman, OA, Venketasubramanian, N, Vladimirov, SK, Vlassov, VV, Vollset, SE, Wang, L, Weiderpass, E, Weintraub, RG, Werdecker, A, Westerman, R, Wijeratne, T, Wilkinson, JD, Wiysonge, CS, Wolfe, CD, Won, S, Wong, JQ, Xu, G, Yadav, AK, Yakob, B, Yalew, AZ, Yano, Y, Yaseri, M, Yebyo, HG, Yip, P, Yonemoto, N, Yoon, SJ, Younis, MZ, Yu, C, Yu, S, Zaidi, Z, Zaki, MELS, Zeeb, H, Zhang, H, Zhao, Y, Zodpey, S, Zoeckler, L, Zuhlke, LJ, Lopez, AD, and Murray, CJ
Subjects: GBD 2015 HIV Collaborators
Abstract: BACKGROUND: Timely assessment of the burden of HIV/AIDS is essential for policy setting and programme evaluation. In this report from the Global Burden of Disease Study 2015 (GBD 2015), we provide national estimates of levels and trends of HIV/AIDS incidence, prevalence, coverage of antiretroviral therapy (ART), and mortality for 195 countries and territories from 1980 to 2015. METHODS: For countries without high-quality vital registration data, we estimated prevalence and incidence with data from antenatal care clinics and population-based seroprevalence surveys, and with assumptions by age and sex on initial CD4 distribution at infection, CD4 progression rates (probability of progression from higher to lower CD4 cell-count category), on and off antiretroviral therapy (ART) mortality, and mortality from all other causes. Our estimation strategy links the GBD 2015 assessment of all-cause mortality and estimation of incidence and prevalence so that for each draw from the uncertainty distribution all assumptions used in each step are internally consistent. We estimated incidence, prevalence, and death with GBD versions of the Estimation and Projection Package (EPP) and Spectrum software originally developed by the Joint United Nations Programme on HIV/AIDS (UNAIDS). We used an open-source version of EPP and recoded Spectrum for speed, and used updated assumptions from systematic reviews of the literature and GBD demographic data. For countries with high-quality vital registration data, we developed the cohort incidence bias adjustment model to estimate HIV incidence and prevalence largely from the number of deaths caused by HIV recorded in cause-of-death statistics. We corrected these statistics for garbage coding and HIV misclassification. FINDINGS: Global HIV incidence reached its peak in 1997, at 3·3 million new infections (95% uncertainty interval [UI] 3·1-3·4 million). Annual incidence has stayed relatively constant at about 2·6 million per year (range 2·5-2·8 million) since 2005, after a period of fast decline between 1997 and 2005. The number of people living with HIV/AIDS has been steadily increasing and reached 38·8 million (95% UI 37·6-40·4 million) in 2015. At the same time, HIV/AIDS mortality has been declining at a steady pace, from a peak of 1·8 million deaths (95% UI 1·7-1·9 million) in 2005, to 1·2 million deaths (1·1-1·3 million) in 2015. We recorded substantial heterogeneity in the levels and trends of HIV/AIDS across countries. Although many countries have experienced decreases in HIV/AIDS mortality and in annual new infections, other countries have had slowdowns or increases in rates of change in annual new infections. INTERPRETATION: Scale-up of ART and prevention of mother-to-child transmission has been one of the great successes of global health in the past two decades. However, in the past decade, progress in reducing new infections has been slow, development assistance for health devoted to HIV has stagnated, and resources for health in low-income countries have grown slowly. Achievement of the new ambitious goals for HIV enshrined in Sustainable Development Goal 3 and the 90-90-90 UNAIDS targets will be challenging, and will need continued efforts from governments and international agencies in the next 15 years to end AIDS by 2030. Funding: We thank the countless individuals who have contributed to the Global Burden of Disease (GBD) Study 2015 in various capacities. We specifically thank Jeffrey Eaton and John Stover. HW and CJLM received funding for this study from the Bill & Melinda Gates Foundation; the National Institute of Mental Health, National Institutes of Health (NIH; R01MH110163); and the National Institute on Aging, NIH (P30AG047845). LJAR acknowledges the support of Qatar National Research Fund (NPRP 04-924-3-251) who provided the main funding for generating the data provided to the GBD-Institute for Health Metrics and Evaluation effort. BPAQ acknowledges institutional support from PRONABEC (National Program of Scholarship and Educational Loan), provided by the Peruvian government. DB is supported by the Bill & Melinda Gates Foundation (grant number OPP1068048). JDN was supported in his contribution to this work by a Fellowship from Fundacao para a Ciencia e a Tecnologia, Portugal (SFRH/BPD/92934/2013). KD is supported by a Wellcome Trust Fellowship in Public Health and Tropical Medicine (grant number 099876). TF received financial support from the Swiss National Science Foundation (SNSF; project number P300P3-154634). AG acknowledges funding from Sistema Nacional de Investigadores de Panama-SNI. PJ is supported by Wellcome Trust-DBT India Alliance Clinical and Public Health Intermediate Fellowship. MK receives research support from the Academy of Finland, the Swedish Research Council, Alzheimerfonden, Alzheimer's Research & Prevention Foundation, Center for Innovative Medicine (CIMED) at Karolinska Institutet South Campus, AXA Research Fund, Wallenberg Clinical Scholars Award from the Knut och Alice Wallenbergs Foundation, and the Sheika Salama Bint Hamdan Al Nahyan Foundation. AK's work was supported by the Miguel Servet contract financed by the CP13/00150 and PI15/00862 projects, integrated into the National R&D&I and funded by the ISCIII (General Branch Evaluation and Promotion of Health Research), and the European Regional Development Fund (ERDF-FEDER). SML is funded by a National Institute for Health Research (NIHR) Clinician Scientist Fellowship (grant number NIHR/CS/010/014). HJL reports grants from the NIHR, EU Innovative Medicines Initiative, Centre for Strategic & International Studies, and WHO. WM is Program analyst, Population and Development, in the Peru Country Office of the United Nations Population Fund, which does not necessarily endorse this study. For UOM, funding from the German National Cohort Consortium (O1ER1511D) is gratefully acknowledged. KR reports grants from NIHR Oxford Biomedical Research Centre, NIHR Career Development Fellowship, and Oxford Martin School during the conduct of the study. GR acknowledges that work related to this paper has been done on the behalf of the GBD Genitourinary Disease Expert Group supported by the International Society of Nephrology (ISN). ISS reports grants from FAPESP (Brazilian public agency). RSS receives institutional support from Universidad de Ciencias Aplicadas y Ambientales, UDCA, Bogota Colombia. SS receives postdoctoral funding from the Fonds de la recherche en sante du Quebec (FRSQ), including its renewal. RTS was supported in part by grant number PROMETEOII/2015/021 from Generalitat Valenciana and the national grant PI14/00894 from ISCIII-FEDER. PY acknowledges support from Strategic Public Policy Research (HKU7003-SPPR-12).
Published: 2016

43. The global burden of cancer 2013 global burden of disease cancer collaboration

Author: Fitzmaurice, C, Dicker, D, Pain, A, Hamavid, H, Moradi-Lakeh, M, Maclntyre, MF, Allen, C, Hansen, G, Woodbrook, R, Wolfe, C, Hamadeh, RR, Antonio, CA, Castaneda-Orjuela, C, Van Gool, CH, Violante, F, Oh, I-H, Deribe, K, Soreide, K, Knibbs, L, Kereselidze, M, Green, M, Moore, A, Cardenas, R, Roy, N, Tillmann, T, Li, Y, Krueger, H, Monasta, L, Dey, S, Sheikhbahaei, S, Hafezi-Nejad, N, Kumar, GA, Werdecker, A, Sreeramareddy, CT, Dandona, L, Wang, H, Vollset, SE, Mokdad, A, Salomon, JA, Lozano, R, Vos, T, Forouzanfar, M, Lopez, A, Gessner, BD, Murray, C, Naghavi, M, Te Ao, B, McMahon, B, Karimkhani, C, Yu, C, Cooke, GS, Schwebel, DC, Carpenter, DO, Pereira, DM, Nash, D, Kazi, DS, De Leo, D, Plass, D, Ukwaja, KN, Thurston, GD, Jin, KY, Simard, EP, Mills, E, Park, E-K, Catala-Lopez, F, DeVeber, G, Gotay, C, Khan, G, Hosgood, HD, Santos, IS, Leasher, JL, Singh, J, Leigh, J, Jonas, JB, Sanabria, J, Beardsley, J, Jacobsen, KH, Takahashi, K, Franklin, RC, Ronfani, L, Montico, M, Naldi, L, Tonelli, M, Geleijnse, J, Petzold, M, Shrime, MG, Younis, M, Yonemoto, N, Breitborde, N, Yip, P, Pourmalek, F, Lotufo, PA, Esteghamati, A, Hankey, GJ, Ali, R, Lunevicius, R, Malekzadeh, R, Dellavalle, R, Weintraub, R, Lucas, R, Hay, R, Rojas-Rueda, D, Westerman, R, Sepanlou, SG, Nolte, S, Patten, S, Weichenthal, S, Abera, SF, Fereshtehnejad, S-M, Shiue, I, Driscoll, T, Vasankari, T, Alsharif, U, Rahimi-Movaghar, V, Vlassov, VV, Marcenes, WS, Mekonnen, W, Melaku, YA, Yano, Y, Al, A, Campos, I, MacLachlan, J, Mueller, U, Kim, D, Trillini, M, Eshrati, B, Williams, HC, Shibuya, K, Dandona, R, Murthy, K, Cowie, B, and Amare, AT
Subjects: CHINESE WOMEN, Adult, Male, Time Factors, Adolescent, HEPATITIS-B-VIRUS, 187 COUNTRIES, Global Health, Disability Evaluation, Young Adult, LUNG-CANCER, Age Distribution, Life Expectancy, Sex Factors, Risk Factors, HEPATOCELLULAR-CARCINOMA, Neoplasms, SYSTEMATIC ANALYSIS, Prevalence, Humans, Sex Distribution, Child, 21 REGIONS, Aged, Aged, 80 and over, Science & Technology, Incidence, Age Factors, Middle Aged, Prognosis, Oncology, Global Burden of Disease Cancer Collaboration, Child, Preschool, RENAL-CELL CANCER, RISK-FACTORS, Female, CIGARETTE-SMOKING, Life Sciences & Biomedicine
Abstract: Importance Cancer is among the leading causes of death worldwide. Current estimates of cancer burden in individual countries and regions are necessary to inform local cancer control strategies. Objective To estimate mortality, incidence, years lived with disability (YLDs), years of life lost (YLLs), and disability-adjusted life-years (DALYs) for 28 cancers in 188 countries by sex from 1990 to 2013. Evidence Review The general methodology of the Global Burden of Disease (GBD) 2013 study was used. Cancer registries were the source for cancer incidence data as well as mortality incidence (MI) ratios. Sources for cause of death data include vital registration system data, verbal autopsy studies, and other sources. The MI ratios were used to transform incidence data to mortality estimates and cause of death estimates to incidence estimates. Cancer prevalence was estimated using MI ratios as surrogates for survival data; YLDs were calculated by multiplying prevalence estimates with disability weights, which were derived from population-based surveys; YLLs were computed by multiplying the number of estimated cancer deaths at each age with a reference life expectancy; and DALYs were calculated as the sum of YLDs and YLLs. Findings In 2013 there were 14.9 million incident cancer cases, 8.2 million deaths, and 196.3 million DALYs. Prostate cancer was the leading cause for cancer incidence (1.4 million) for men and breast cancer for women (1.8 million). Tracheal, bronchus, and lung (TBL) cancer was the leading cause for cancer death in men and women, with 1.6 million deaths. For men, TBL cancer was the leading cause of DALYs (24.9 million). For women, breast cancer was the leading cause of DALYs (13.1 million). Age-standardized incidence rates (ASIRs) per 100 000 and age-standardized death rates (ASDRs) per 100 000 for both sexes in 2013 were higher in developing vs developed countries for stomach cancer (ASIR, 17 vs 14; ASDR, 15 vs 11), liver cancer (ASIR, 15 vs 7; ASDR, 16 vs 7), esophageal cancer (ASIR, 9 vs 4; ASDR, 9 vs 4), cervical cancer (ASIR, 8 vs 5; ASDR, 4 vs 2), lip and oral cavity cancer (ASIR, 7 vs 6; ASDR, 2 vs 2), and nasopharyngeal cancer (ASIR, 1.5 vs 0.4; ASDR, 1.2 vs 0.3). Between 1990 and 2013, ASIRs for all cancers combined (except nonmelanoma skin cancer and Kaposi sarcoma) increased by more than 10% in 113 countries and decreased by more than 10% in 12 of 188 countries. Conclusions and Relevance Cancer poses a major threat to public health worldwide, and incidence rates have increased in most countries since 1990. The trend is a particular threat to developing nations with health systems that are ill-equipped to deal with complex and expensive cancer treatments. The annual update on the Global Burden of Cancer will provide all stakeholders with timely estimates to guide policy efforts in cancer prevention, screening, treatment, and palliation.
Published: 2015

44. Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013

Author: Vos, T, Barber, Rm, Bell, B, Bertozzi Villa, A, Biryukov, S, Bolliger, I, Charlson, F, Davis, A, Degenhardt, L, Dicker, D, Duan, L, Erskine, H, Feigin, Vl, Ferrari, Aj, Fitzmaurice, C, Fleming, T, Graetz, N, Guinovart, C, Haagsma, J, Hansen, Gm, Hanson, Sw, Heuton, Kr, Higashi, H, Kassebaum, N, Kyu, H, Laurie, E, Liang, X, Lofgren, K, Lozano, R, Macintyre, Mf, Moradi Lakeh, M, Naghavi, M, Nguyen, G, Odell, S, Ortblad, K, Roberts, Da, Roth, Ga, Sandar, L, Serina, Pt, Stanaway, Jd, Steiner, C, Thomas, B, Vollset, Se, Whiteford, H, Wolock, Tm, Ye, P, Zhou, M, Ãvila, Ma, Aasvang, Gm, Abbafati, C, Abbasoglu, Ozgoren, A, Abd Allah, F, Abdel, Aziz, Abera, Sf, Aboyans, V, Abraham, Jp, Abraham, B, Abubakar, I, Abu Raddad, Lj, Abu Rmeileh, Nm, Aburto, Tc, Achoki, T, Ackerman, In, Adelekan, A, Ademi, Z, Adou, Ak, Adsuar, Jc, Arnlov, J, Agardh, Ee, Khabouri, Al, Alam, Ss, Alasfoor, D, Albittar, Mi, Alegretti, Ma, Aleman, Av, Alemu, Za, Alfonso Cristancho, R, Alhabib, S, Ali, R, Alla, F, Allebeck, P, Allen, Pj, Almazroa, Ma, Alsharif, U, Alvarez, E, Alvis, Guzman, Ameli, N, O, Amini, H, Ammar, W, Anderson, Bo, Anderson, Hr, Antonio, Ca, Anwari, P, Apfel, H, Arsenijevic, Vs, Artaman, A, Asghar, Rj, Assadi, R, Atkins, Ls, Atkinson, C, Badawi, A, Bahit, Mc, Bakfalouni, T, Balakrishnan, K, Balalla, S, Banerjee, A, Barker Collo, Sl, Barquera, S, Barregard, L, Barrero, Lh, Basu, S, Basu, A, Baxter, A, Beardsley, J, Bedi, N, Beghi, E, Bekele, T, Bell, Ml, Benjet, C, Bennett, Da, Bensenor, Im, Benzian, H, Bernabe, E, Beyene, Tj, Bhala, N, Bhalla, A, Bhutta, Z, Bienhoff, K, Bikbov, B, Bin, Abdulhak, Blore, Jd, Blyth, Fm, Bohensky, Ma, Bora, Basara, B, Borges, G, Bornstein, Nm, Bose, D, Boufous, S, Bourne, Rr, Boyers, Ln, Brainin, M, Brauer, M, Brayne, Ce, Brazinova, A, Breitborde, Nj, Brenner, H, Briggs, Ad, Brooks, Pm, Brown, J, Brugha, Ts, Buchbinder, R, Buckle, Gc, Bukhman, G, Bulloch, Ag, Burch, M, Burnett, R, Cardenas, R, Cabral, Nl, Campos, Nonato, Campuzano, Ir, Carapetis, Jc, Carpenter, Do, Caso, V, Castaneda Orjuela, Ca, Catala Lopez, F, Chadha, Vk, Chang, Jc, Chen, H, Chen, W, Chiang, Pp, Chimed Ochir, O, Chowdhury, R, Christensen, H, Christophi, Ca, Chugh, Ss, Cirillo, Massimo, Coggeshall, M, Cohen, A, Colistro, V, Colquhoun, Sm, Contreras, Ag, Cooper, Lt, Cooper, C, Cooperrider, K, Coresh, J, Cortinovis, M, Criqui, Mh, Crump, Ja, Cuevas Nasu, L, Dandona, R, Dandona, L, Dansereau, E, Dantes, Hg, Dargan, Pi, Davey, G, Davitoiu, Dv, Dayama, A, La, De, Cruz, Gongora, De, V, Vega, La, De, Sf, Leo, D, Del, Pozo, Cruz, Dellavalle, Rp, Deribe, K, Derrett, S, Des, Jarlais, Dessalegn, M, Deveber, Ga, Dharmaratne, Sd, Diaz Torne, C, Ding, El, Dokova, K, Dorsey, Er, Driscoll, Tr, Duber, H, Durrani, Am, Edmond, Km, Ellenbogen, Rg, Endres, M, Ermakov, Sp, Eshrati, B, Esteghamati, A, Estep, K, Fahimi, S, Farzadfar, F, Fay, Df, Felson, Dt, Fereshtehnejad, Sm, Fernandes, Jg, Ferri, Cp, Flaxman, A, Foigt, N, Foreman, Kj, Fowkes, Fg, Franklin, Rc, Furst, T, Futran, Nd, Gabbe, Bj, Gankpe, Fg, Garcia, Guerra, Geleijnse, Fa, Gessner, Bd, Gibney, Kb, Gillum, Rf, Ginawi, Ia, Giroud, M, Giussani, G, Goenka, S, Goginashvili, K, Gona, P, Gonzalez, De, Cosio, T, Gosselin, Ra, Gotay, Cc, Goto, A, Gouda, Hn, Guerrant, Rl, Gugnani, Hc, Gunnell, D, Gupta, R, Gutierrez, Ra, Hafezi Nejad, N, Hagan, H, Halasa, Y, Hamadeh, Rr, Hamavid, H, Hammami, M, Hankey, Gj, Hao, Y, Harb, Hl, Haro, Jm, Havmoeller, R, Hay, Rj, Hay, S, Hedayati, Mt, Heredia, Pi, Heydarpour, P, Hijar, M, Hoek, Hw, Hoffman, Hj, Hornberger, Jc, Hosgood, Hd, Hossain, M, Hotez, Pj, Hoy, Dg, Hsairi, M, Hu, H, Hu, G, Huang, Jj, Huang, C, Huiart, L, Husseini, A, Iannarone, M, Iburg, Km, Innos, K, Inoue, M, Jacobsen, Kh, Jassal, Sk, Jeemon, P, Jensen, Pn, Jha, V, Jiang, G, Jiang, Y, Jonas, Jb, Joseph, J, Juel, K, Kan, H, Karch, A, Karimkhani, C, Karthikeyan, G, Katz, R, Kaul, A, Kawakami, N, Kazi, Ds, Kemp, Ah, Kengne, Ap, Khader, Ys, Khalifa, Se, Khan, Ea, Khan, G, Khang, Yh, Khonelidze, I, Kieling, C, Kim, D, Kim, S, Kimokoti, Rw, Kinfu, Y, Kinge, Jm, Kissela, Bm, Kivipelto, M, Knibbs, L, Knudsen, Ak, Kokubo, Y, Kosen, S, Kramer, A, Kravchenko, M, Krishnamurthi, Rv, Krishnaswami, S, Kuate, Defo, Kucuk, B, Bicer, B, Kuipers, Ej, Kulkarni, Vs, Kumar, K, Kumar, Ga, Kwan, Gf, Lai, T, Lalloo, R, Lam, H, Lan, Q, Lansingh, Vc, Larson, H, Larsson, A, Lawrynowicz, Ae, Leasher, Jl, Lee, Jt, Leigh, J, Leung, R, Levi, M, Li, B, Li, Y, Liang, J, Lim, S, Lin, Hh, Lind, M, Lindsay, Mp, Lipshultz, Se, Liu, S, Lloyd, Bk, Lockett, Ohno, S, Logroscino, G, Looker, Kj, Lopez, Ad, Lopez Olmedo, N, Lortet Tieulent, J, Lotufo, Pa, Low, N, Lucas, Rm, Lunevicius, R, Lyons, Ra, Ma, J, Ma, S, Mackay, Mt, Majdan, M, Malekzadeh, R, Mapoma, Cc, Marcenes, W, March, Lm, Margono, C, Marks, Gb, Marzan, Mb, Masci, Jr, Mason Jones, Aj, Matzopoulos, Rg, Mayosi, Bm, Mazorodze, Tt, Mcgill, Nw, Mcgrath, Jj, Mckee, M, Mclain, A, Mcmahon, Bj, Meaney, Pa, Mehndiratta, Mm, Mejia Rodriguez, F, Mekonnen, W, Melaku, Ya, Meltzer, M, Memish, Za, Mensah, G, Meretoja, A, Mhimbira, Fa, Micha, R, Miller, Tr, Mills, Ej, Mitchell, Pb, Mock, Cn, Moffitt, Te, Mohamed, Ibrahim, N, Mohammad, Ka, Mokdad, Ah, Mola, Gl, Monasta, L, Montico, M, Montine, Tj, Moore, Ar, Moran, Ae, Morawska, L, Mori, R, Moschandreas, J, Moturi, Wn, Moyer, M, Mozaffarian, D, Mueller, Uo, Mukaigawara, M, Murdoch, Me, Murray, J, Murthy, Ks, Naghavi, P, Nahas, Z, Naheed, A, Naidoo, Ks, Naldi, L, Nand, D, Nangia, V, Narayan, Km, Nash, D, Nejjari, C, Neupane, Sp, Newman, Lm, Newton, Cr, Ng, M, Ngalesoni, Fn, Nhung, Nt, Nisar, Mi, Nolte, S, Norheim, Of, Norman, Re, Norrving, B, Nyakarahuka, L, Ih, Oh, Ohkubo, T, Omer, Sb, Opio, Jn, Ortiz, A, Pandian, Jd, Panelo, Ci, Papachristou, C, Park, Ek, Parry, Cd, Caicedo, Aj, Patten, Sb, Paul, Vk, Pavlin, Bi, Pearce, N, Pedraza, Ls, Pellegrini, Ca, Pereira, Dm, Perez Ruiz, Fp, Perico, N, Pervaiz, A, Pesudovs, K, Peterson, Cb, Petzold, M, Phillips, Mr, Phillips, D, Phillips, B, Piel, Fb, Plass, D, Poenaru, D, Polanczyk, Gv, Polinder, S, Pope, Ca, Popova, S, Poulton, Rg, Pourmalek, F, Prabhakaran, D, Prasad, Nm, Qato, D, Quistberg, Da, Rafay, A, Rahimi, K, Rahimi Movaghar, V, Rahman, Su, Raju, M, Rakovac, I, Rana, Sm, Razavi, H, Refaat, A, Rehm, J, Remuzzi, G, Resnikoff, S, Ribeiro, Al, Riccio, Pm, Richardson, L, Richardus, Jh, Riederer, Am, Robinson, M, Roca, A, Rodriguez, A, Rojas Rueda, D, Ronfani, L, Rothenbacher, D, Roy, N, Ruhago, Gm, Sabin, N, Sacco, Rl, Ksoreide, K, Saha, S, Sahathevan, R, Sahraian, Ma, Sampson, U, Sanabria, Jr, Sanchez Riera, L, Santos, Is, Satpathy, M, Saunders, Je, Sawhney, M, Saylan, Mi, Scarborough, P, Schoettker, B, Schneider, Ij, Schwebel, Dc, Scott, Jg, Seedat, S, Sepanlou, Sg, Serdar, B, Servan Mori, Ee, Shackelford, K, Shaheen, A, Shahraz, S, Shamah, Levy, T, Shangguan, S, She, J, Sheikhbahaei, S, Shepard, Ds, Shi, P, Shibuya, K, Shinohara, Y, Shiri, R, Shishani, K, Shiue, I, Shrime, Mg, Sigfusdottir, Id, Silberberg, Dh, Simard, Ep, Sindi, S, Singh, Ja, Singh, L, Skirbekk, V, Sliwa, K, Soljak, M, Soneji, S, Soshnikov, Ss, Speyer, P, Sposato, La, Sreeramareddy, Ct, Stoeckl, H, Stathopoulou, Vk, Steckling, N, Stein, Mb, Stein, Dj, Steiner, Tj, Stewart, A, Stork, E, Stovner, Lj, Stroumpoulis, K, Sturua, L, Sunguya, Bf, Swaroop, M, Sykes, Bl, Tabb, Km, Takahashi, K, Tan, F, Tandon, N, Tanne, D, Tanner, M, Tavakkoli, M, Taylor, Hr, Ao, Te, Temesgen, Am, Ten, Have, M, Tenkorang, Ey, Terkawi, As, Theadom, Am, Thomas, E, Thorne Lyman, Al, Thrift, Ag, Tleyjeh, Im, Tonelli, M, Topouzis, F, Towbin, Ja, Toyoshima, H, Traebert, J, Tran, Bx, Trasande, L, Trillini, M, Truelsen, T, Trujillo, U, Tsilimbaris, M, Tuzcu, Em, Ukwaja, Kn, Undurraga, Ea, Uzun, Sb, Van, Brakel, Van, Wh, Vijver, De, Van, S, Dingenen, R, Van, Gool, Varakin, Yy, Vasankari, Tj, Vavilala, Ms, Veerman, Lj, Velasquez, Melendez, G, Venketasubramanian, N, Vijayakumar, L, Villalpando, S, Violante, Fs, Vlassov, Vv, Waller, S, Wallin, Mt, Wan, X, Wang, L, Wang, J, Wang, Y, Warouw, Ts, Weichenthal, S, Weiderpass, E, Weintraub, Rg, Werdecker, A, Wessells, Kr, Westerman, R, Wilkinson, Jd, Williams, Hc, Williams, Tn, Woldeyohannes, Sm, Wolfe, Cd, Wong, Jq, Wong, H, Woolf, Ad, Wright, Jl, Wurtz, B, Xu, G, Yang, G, Yano, Y, Yenesew, Ma, Yentur, Gk, Yip, P, Yonemoto, N, Yoon, Sj, Younis, M, Yu, C, Kim, Ky, Zaki, Mel, Zhang, Y, Zhao, Z, Zhao, Y, Zhu, J, Zonies, D, Zunt, Jr, Salomon, Ja, Murray, C. J., Vos, T, Barber, Rm, Bell, B, Bertozzi-Villa, A, Biryukov, S, Bolliger, I, Charlson, F, Davis, A, Degenhardt, L, Dicker, D, Duan, L, Erskine, H, Feigin, Vl, Ferrari, Aj, Fitzmaurice, C, Fleming, T, Graetz, N, Guinovart, C, Haagsma, J, Hansen, Gm, Hanson, Sw, Heuton, Kr, Higashi, H, Kassebaum, N, Kyu, H, Laurie ELiang, X, Lofgren, K, Lozano, R, Macintyre, Mf, Moradi-Lakeh, M, Naghavi, M, Nguyen, G, Odell, S, Ortblad, K, Roberts, Da, Roth, Ga, Sandar, L, Serina, Pt, Stanaway, Jd, Steiner, C, Thomas, B, Vollset, Se, Whiteford, H, Wolock, Tm, Ye, P, Zhou, M, Ãvila, Ma, Aasvang, Gm, Abbafati, C, Abbasoglu Ozgoren, A, Abd-Allah, F, Abdel Aziz MI, Abera, Sf, Aboyans, V, Abraham, Jp, Abraham, B, Abubakar, I, Abu-Raddad, Lj, Abu-Rmeileh, Nm, Aburto, Tc, Achoki TAckerman IN, Adelekan, A, Ademi, Z, Adou, Ak, Adsuar, Jc, Arnlov, J, Agardh, Ee, Al Khabouri MJ, Alam, S, Alasfoor, D, Albittar, Mi, Alegretti MAAleman AV, Alemu, Za, Alfonso-Cristancho, R, Alhabib, S, Ali, R, Alla, F, Allebeck, P, Allen, Pj, Almazroa, Ma, Alsharif, U, Alvarez, E, Alvis-Guzman NAmeli, O, Amini, H, Ammar, W, Anderson, Bo, Anderson, Hr, Antonio, Ca, Anwari, P, Apfel, H, Arsenijevic, V, Artaman, A, Asghar, Rj, Assadi, R, Atkins, L, Atkinson, C, Badawi, A, Bahit, Mc, Bakfalouni, T, Balakrishnan, K, Balalla, S, Banerjee, A, Barker-Collo, Sl, Barquera, S, Barregard, L, Barrero LHBasu, S, Basu, A, Baxter, A, Beardsley, J, Bedi, N, Beghi, E, Bekele, T, Bell, Ml, Benjet, C, Bennett, Da, Bensenor, Im, Benzian, H, Bernabe, E, Beyene TJBhala, N, Bhalla, A, Bhutta, Z, Bienhoff, K, Bikbov, B, Bin Abdulhak, A, Blore, Jd, Blyth, Fm, Bohensky, Ma, Bora Basara, B, Borges, G, Bornstein, Nm, Bose, D, Boufous, S, Bourne, Rr, Boyers, Ln, Brainin, M, Brauer, M, Brayne, Ce, Brazinova, A, Breitborde, Nj, Brenner, H, Briggs, Ad, Brooks, Pm, Brown JBrugha TS, Buchbinder, R, Buckle, Gc, Bukhman, G, Bulloch, Ag, Burch, M, Burnett, R, Cardenas, R, Cabral, Nl, Campos Nonato IR, Campuzano JCCarapetis JR, Carpenter, Do, Caso, V, Castaneda-Orjuela, Ca, Catala-Lopez, F, Chadha, Vk, Chang, Jc, Chen, H, Chen, W, Chiang, Pp, Chimed-Ochir, O, Chowdhury, R, Christensen, H, Christophi, Ca, Chugh, S, Cirillo, M, Coggeshall, M, Cohen, A, Colistro, V, Colquhoun, Sm, Contreras, Ag, Cooper LTCooper, C, Cooperrider, K, Coresh, J, Cortinovis, M, Criqui, Mh, Crump, Ja, Cuevas-Nasu, L, Dandona, R, Dandona, L, Dansereau, E, Dantes, Hg, Dargan, Pi, Davey, G, Davitoiu, Dv, Dayama, A, De la Cruz-Gongora, V, de la Vega SF, De Leo, D, del Pozo-Cruz, B, Dellavalle, Rp, Deribe, K, Derrett, S, Des Jarlais DC, Dessalegn, M, Deveber, Ga, Dharmaratne, Sd, Diaz-Torne, C, Ding, El, Dokova, K, Dorsey, Er, Driscoll, Tr, Duber, H, Durrani, Am, Edmond, Km, Ellenbogen, Rg, Endres, M, Ermakov, Sp, Eshrati, B, Esteghamati, A, Estep, K, Fahimi, S, Farzadfar, F, Fay, Df, Felson, Dt, Fereshtehnejad SMFernandes JG, Ferri, Cp, Flaxman, A, Foigt, N, Foreman, Kj, Fowkes, Fg, Franklin, Rc, Furst, T, Futran, Nd, Gabbe, Bj, Gankpe, Fg, Garcia-Guerra FAGeleijnse JM, Gessner, Bd, Gibney, Kb, Gillum, Rf, Ginawi, Ia, Giroud, M, Giussani, G, Goenka, S, Goginashvili, K, Gona, P, Gonzalez de Cosio TGosselin RA, Gotay, Cc, Goto, A, Gouda, Hn, Guerrant, Rl, Gugnani, Hc, Gunnell, D, Gupta, R, Gutierrez, Ra, Hafezi-Nejad, N, Hagan HHalasa, Y, Hamadeh, Rr, Hamavid, H, Hammami, M, Hankey, Gj, Hao, Y, Harb, Hl, Haro, Jm, Havmoeller, R, Hay, Rj, Hay, S, Hedayati, Mt, Heredia Pi IB, Heydarpour, P, Hijar, M, Hoek, Hw, Hoffman, Hj, Hornberger, Jc, Hosgood, Hd, Hossain, M, Hotez, Pj, Hoy, Dg, Hsairi, M, Hu, H, Hu, G, Huang JJHuang, C, Huiart, L, Husseini, A, Iannarone, M, Iburg, Km, Innos, K, Inoue, M, Jacobsen, Kh, Jassal, Sk, Jeemon, P, Jensen, Pn, Jha, V, Jiang, G, Jiang YJonas JB, Joseph, J, Juel, K, Kan, H, Karch, A, Karimkhani, C, Karthikeyan, G, Katz, R, Kaul, A, Kawakami, N, Kazi, D, Kemp, Ah, Kengne, Ap, Khader, Y, Khalifa, Se, Khan, Ea, Khan, G, Khang, Yh, Khonelidze, I, Kieling, C, Kim, D, Kim, S, Kimokoti, Rw, Kinfu, Y, Kinge, Jm, Kissela, Bm, Kivipelto MKnibbs, L, Knudsen, Ak, Kokubo, Y, Kosen, S, Kramer, A, Kravchenko, M, Krishnamurthi, Rv, Krishnaswami, S, Kuate Defo, B, Kucuk Bicer, B, Kuipers EJKulkarni VS, Kumar, K, Kumar, Ga, Kwan, Gf, Lai, T, Lalloo, R, Lam, H, Lan, Q, Lansingh, Vc, Larson, H, Larsson, A, Lawrynowicz, Ae, Leasher, Jl, Lee, Jt, Leigh, J, Leung, R, Levi, M, Li, B, Li, Y, Liang, J, Lim, S, Lin, Hh, Lind, M, Lindsay, Mp, Lipshultz, Se, Liu, S, Lloyd, Bk, Lockett Ohno, S, Logroscino, G, Looker, Kj, Lopez, Ad, Lopez-Olmedo, N, Lortet-Tieulent, J, Lotufo, Pa, Low, N, Lucas, Rm, Lunevicius, R, Lyons, Ra, Ma, J, Ma, S, Mackay MTMajdan, M, Malekzadeh, R, Mapoma, Cc, Marcenes, W, March, Lm, Margono, C, Marks, Gb, Marzan, Mb, Masci, Jr, Mason-Jones, Aj, Matzopoulos RGMayosi BM, Mazorodze, Tt, Mcgill, Nw, Mcgrath, Jj, Mckee, M, Mclain, A, Mcmahon, Bj, Meaney, Pa, Mehndiratta, Mm, Mejia-Rodriguez, F, Mekonnen, W, Melaku, Ya, Meltzer, M, Memish, Za, Mensah, G, Meretoja, A, Mhimbira, Fa, Micha, R, Miller, Tr, Mills, Ej, Mitchell, Pb, Mock, Cn, Moffitt TEMohamed Ibrahim, N, Mohammad, Ka, Mokdad, Ah, Mola, Gl, Monasta, L, Montico, M, Montine, Tj, Moore, Ar, Moran, Ae, Morawska, L, Mori RMoschandreas, J, Moturi, Wn, Moyer, M, Mozaffarian, D, Mueller, Uo, Mukaigawara, M, Murdoch, Me, Murray, J, Murthy, K, Naghavi, P, Nahas ZNaheed, A, Naidoo, K, Naldi, L, Nand, D, Nangia, V, Narayan, Km, Nash, D, Nejjari, C, Neupane, Sp, Newman, Lm, Newton, Cr, Ng, M, Ngalesoni FNNhung NT, Nisar, Mi, Nolte, S, Norheim, Of, Norman, Re, Norrving, B, Nyakarahuka, L, Oh, Ih, Ohkubo, T, Omer, Sb, Opio, Jn, Ortiz, A, Pandian JDPanelo CI, Papachristou, C, Park, Ek, Parry, Cd, Caicedo, Aj, Patten, Sb, Paul, Vk, Pavlin, Bi, Pearce, N, Pedraza, L, Pellegrini, Ca, Pereira, Dm, Perez-Ruiz, Fp, Perico, N, Pervaiz, A, Pesudovs, K, Peterson, Cb, Petzold, M, Phillips, Mr, Phillips, D, Phillips, B, Piel, Fb, Plass, D, Poenaru, D, Polanczyk GVPolinder, S, Pope, Ca, Popova, S, Poulton, Rg, Pourmalek, F, Prabhakaran, D, Prasad, Nm, Qato, D, Quistberg, Da, Rafay, A, Rahimi, K, Rahimi-Movaghar, V, Rahman, Su, Raju, M, Rakovac, I, Rana, Sm, Razavi, H, Refaat, A, Rehm, J, Remuzzi, G, Resnikoff, S, Ribeiro, Al, Riccio, Pm, Richardson, L, Richardus, Jh, Riederer, Am, Robinson, M, Roca, A, Rodriguez, A, Rojas-Rueda, D, Ronfani, L, Rothenbacher, D, Roy, N, Ruhago, Gm, Sabin, N, Sacco, Rl, Ksoreide, K, Saha, S, Sahathevan, R, Sahraian, Ma, Sampson, U, Sanabria, Jr, Sanchez-Riera, L, Santos, I, Satpathy, M, Saunders, Je, Sawhney, M, Saylan MIScarborough, P, Schoettker, B, Schneider, Ij, Schwebel, Dc, Scott, Jg, Seedat, S, Sepanlou, Sg, Serdar, B, Servan-Mori, Ee, Shackelford, K, Shaheen AShahraz, S, Shamah Levy, T, Shangguan, S, She, J, Sheikhbahaei, S, Shepard, D, Shi, P, Shibuya, K, Shinohara, Y, Shiri, R, Shishani, K, Shiue, I, Shrime, Mg, Sigfusdottir, Id, Silberberg, Dh, Simard, Ep, Sindi, S, Singh, Ja, Singh, L, Skirbekk, V, Sliwa, K, Soljak, M, Soneji, S, Soshnikov, S, Speyer PSposato LA, Sreeramareddy, Ct, Stoeckl, H, Stathopoulou, Vk, Steckling, N, Stein, Mb, Stein, Dj, Steiner, Tj, Stewart, A, Stork, E, Stovner LJStroumpoulis, K, Sturua, L, Sunguya, Bf, Swaroop, M, Sykes, Bl, Tabb, Km, Takahashi, K, Tan, F, Tandon, N, Tanne, D, Tanner, M, Tavakkoli, M, Taylor, Hr, Te Ao BJ, Temesgen, Am, Ten Have, M, Tenkorang, Ey, Terkawi, A, Theadom, Am, Thomas, E, Thorne-Lyman, Al, Thrift, Ag, Tleyjeh, Im, Tonelli, M, Topouzis, F, Towbin, Ja, Toyoshima, H, Traebert, J, Tran, Bx, Trasande, L, Trillini, M, Truelsen, T, Trujillo, U, Tsilimbaris, M, Tuzcu, Em, Ukwaja KNUndurraga EA, Uzun, Sb, van Brakel WH, van de Vijver, S, Van Dingenen, R, van Gool CH, Varakin, Yy, Vasankari, Tj, Vavilala, M, Veerman LJVelasquez-Melendez, G, Venketasubramanian, N, Vijayakumar, L, Villalpando, S, Violante, F, Vlassov, Vv, Waller, S, Wallin, Mt, Wan, X, Wang, L, Wang, J, Wang, Y, Warouw, T, Weichenthal, S, Weiderpass, E, Weintraub, Rg, Werdecker, A, Wessells, Kr, Westerman, R, Wilkinson, Jd, Williams HCWilliams TN, Woldeyohannes, Sm, Wolfe, Cd, Wong, Jq, Wong, H, Woolf, Ad, Wright, Jl, Wurtz, B, Xu, G, Yang, G, Yano, Y, Yenesew, Ma, Yentur GKYip, P, Yonemoto, N, Yoon, Sj, Younis, M, Yu, C, Kim, Ky, Zaki Mel, S, Zhang, Y, Zhao, Z, Zhao, Y, Zhu, J, Zonies, D, Zunt, Jr, Salomon, Ja, Murray, Cj., Vos, Theo, Barber, Ryan M., Bell, Brad, Bertozzi-Villa, Amelia, Biryukov, Stan, Bolliger, Ian, Charlson, Fiona, Davis, Adrian, Degenhardt, Louisa, Dicker, Daniel, Duan, Leilei, Erskine, Holly, Feigin, Valery L., Ferrari, Alize J., Fitzmaurice, Christina, Fleming, Thoma, Graetz, Nichola, Guinovart, Caterina, Haagsma, Juanita, Hansen, Gillian M., Hanson, Sarah Wulf, Heuton, Kyle R., Higashi, Hideki, Kassebaum, Nichola, Kyu, Hmwe, Laurie, Evan, Liang, Xiofeng, Lofgren, Katherine, Lozano, Rafael, Macintyre, Michael F., Moradi-Lakeh, Maziar, Naghavi, Mohsen, Nguyen, Grant, Odell, Shaun, Ortblad, Katrina, Roberts, David Allen, Roth, Gregory A., Sandar, Logan, Serina, Peter T., Stanaway, Jeffrey D., Steiner, Caitlyn, Thomas, Bernadette, Vollset, Stein Emil, Whiteford, Harvey, Wolock, Timothy M., Ye, Pengpeng, Zhou, Maigeng, Ãvila, Marco A., Aasvang, Gunn Marit, Abbafati, Cristiana, Ozgoren, Ayse Abbasoglu, Abd-Allah, Foad, Aziz, Muna I. Abdel, Abera, Semaw F., Aboyans, Victor, Abraham, Jerry P., Abraham, Biju, Abubakar, Ibrahim, Abu-Raddad, Laith J., Abu-Rmeileh, Niveen M.E., Aburto, Tania C., Achoki, Tom, Ackerman, Ilana N., Adelekan, Ademola, Ademi, Zanfina, Adou, Arsène K., Adsuar, Josef C., Arnlov, Johan, Agardh, Emilie E., Al Khabouri, Mazin J., Alam, Sayed Saidul, Alasfoor, Deena, Albittar, Mohammed I., Alegretti, Miguel A., Aleman, Alicia V., Alemu, Zewdie A., Alfonso-Cristancho, Rafael, Alhabib, Samia, Ali, Raghib, Alla, Francoi, Allebeck, Peter, Allen, Peter J., Almazroa, Mohammad Abdulaziz, Alsharif, Ubai, Alvarez, Elena, Alvis-Guzman, Nelson, Ameli, Omid, Amini, Heresh, Ammar, Walid, Anderson, Benjamin O., Anderson, H. Ro, Antonio, Carl Abelardo T., Anwari, Palwasha, Apfel, Henry, Arsenijevic, Valentain S. 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Heredia, Heydarpour, Pouria, Hijar, Martha, Hoek, Hans W., Hoffman, Howard J., Hornberger, John C., Hosgood, H. Dean, Hossain, Mazeda, Hotez, Peter J., Hoy, Damian G., Hsairi, Mohamed, Hu, Howard, Hu, Guoqing, Huang, John J., Huang, Cheng, Huiart, Laetitia, Husseini, Abdullatif, Iannarone, Marissa, Iburg, Kim M., Innos, Kaire, Inoue, Manami, Jacobsen, Kathryn H., Jassal, Simerjot K., Jeemon, Panniyammakal, Jensen, Paul N., Jha, Vivekanand, Jiang, Guohong, Jiang, Ying, Jonas, Jost B., Joseph, Jonathan, Juel, Knud, Kan, Haidong, Karch, Andre, Karimkhani, Chante, Karthikeyan, Ganesan, Katz, Ronit, Kaul, Anil, Kawakami, Norito, Kazi, Dhruv S., Kemp, Andrew H., Kengne, Andre P., Khader, Yousef S., Khalifa, Shams Eldin A.H., Khan, Ejaz A., Khan, Gulfaraz, Khang, Young-Ho, Khonelidze, Irma, Kieling, Christian, Kim, Daniel, Kim, Sungroul, Kimokoti, Ruth W., Kinfu, Yohanne, Kinge, Jonas M., Kissela, Brett M., Kivipelto, Miia, Knibbs, Luke, Knudsen, Ann Kristin, Kokubo, Yoshihiro, Kosen, Soewarta, Kramer, Alexander, Kravchenko, Michael, Krishnamurthi, Rita V., Krishnaswami, Sanjay, Defo, Barthelemy Kuate, Bicer, Burcu Kucuk, Kuipers, Ernst J., Kulkarni, Veena S., Kumar, Kaushalendra, Kumar, G Anil, Kwan, Gene F., Lai, Taavi, Lalloo, Ratilal, Lam, Hilton, Lan, Qing, Lansingh, Van C., Larson, Heidi, Larsson, Ander, Lawrynowicz, Alicia E.B., Leasher, Janet L., Lee, Jong-Tae, Leigh, Jame, Leung, Ricky, Levi, Miriam, Li, Bin, Li, Yichong, Li, Yongmei, Liang, Juan, Lim, Stephen, Lin, Hsien-Ho, Lind, Margaret, Lindsay, M Patrice, Lipshultz, Steven E., Liu, Shiwei, Lloyd, Belinda K., Ohno, Summer Lockett, Logroscino, Giancarlo, Looker, Katharine J., Lopez, Alan D., Lopez-Olmedo, Nancy, Lortet-Tieulent, Joannie, Lotufo, Paulo A., Low, Nicola, Lucas, Robyn M., Lunevicius, Raimunda, Lyons, Ronan A., Ma, Jixiang, Ma, Stefan, Mackay, Mark T., Majdan, Marek, Malekzadeh, Reza, Mapoma, Christopher C., Marcenes, Wagner, March, Lyn M., Margono, Chri, Marks, Guy B., Marzan, Melvin B., Masci, Joseph R., Mason-Jones, Amanda J., Matzopoulos, Richard G., Mayosi, Bongani M., Mazorodze, Tasara T., Mcgill, Neil W., Mcgrath, John J., Mckee, Martin, Mclain, Abby, Mcmahon, Brian J., Meaney, Peter A., Mehndiratta, Man Mohan, Mejia-Rodriguez, Fabiola, Mekonnen, Wubegzier, Melaku, Yohannes A., Meltzer, Michele, Memish, Ziad A., Mensah, George, Meretoja, Atte, Mhimbira, Francis A., Micha, Renata, Miller, Ted R., Mills, Edward J., Mitchell, Philip B., Mock, Charles N., Moffitt, Terrie E., Ibrahim, Norlinah Mohamed, Mohammad, Karzan A., Mokdad, Ali H., Mola, Glen L., Monasta, Lorenzo, Montico, Marcella, Montine, Thomas J., Moore, Ami R., Moran, Andrew E., Morawska, Lidia, Mori, Rintaro, Moschandreas, Joanna, Moturi, Wilkister N., Moyer, Madeline, Mozaffarian, Dariush, Mueller, Ulrich O., Mukaigawara, Mitsuru, Murdoch, Michele E., Murray, Joseph, Murthy, Kinnari S., Naghavi, Paria, Nahas, Ziad, Naheed, Aliya, Naidoo, Kovin S., Naldi, Luigi, Nand, Devina, Nangia, Vinay, Narayan, K.M. Venkat, Nash, Deni, Nejjari, Chakib, Neupane, Sudan P., Newman, Lori M., Newton, Charles R., Ng, Marie, Ngalesoni, Frida N., Nhung, Nguyen T., Nisar, Muhammad I., Nolte, Sandra, Norheim, Ole F., Norman, Rosana E., Norrving, Bo, Nyakarahuka, Luke, Oh, In Hwan, Ohkubo, Takayoshi, Omer, Saad B., Opio, John Nelson, Ortiz, Alberto, Pandian, Jeyaraj D., Panelo, Carlo Irwin A., Papachristou, Christina, Park, Eun-Kee, Parry, Charles D., Caicedo, Angel J. Paternina, Patten, Scott B., Paul, Vinod K., Pavlin, Boris I., Pearce, Neil, Pedraza, Lilia S., Pellegrini, Carlos A., Pereira, David M., Perez-Ruiz, Fernando P., Perico, Norberto, Pervaiz, Aslam, Pesudovs, Konrad, Peterson, Carrie B., Petzold, Max, Phillips, Michael R., Phillips, David, Phillips, Bryan, Piel, Frederic B., Plass, Dietrich, Poenaru, Dan, Polanczyk, Guilherme V., Polinder, Suzanne, Pope, C.A., Popova, Svetlana, Poulton, Richie G., Pourmalek, Farshad, Prabhakaran, Dorairaj, Prasad, Noela M., Qato, Dima, Quistberg, D.A., Rafay, Anwar, Rahimi, Kazem, Rahimi-Movaghar, Vafa, Rahman, Sajjad Ur, Raju, Murugesan, Rakovac, Ivo, Rana, Saleem M., Razavi, Homie, Refaat, Amany, Rehm, Jurgen, Remuzzi, Giuseppe, Resnikoff, Serge, Ribeiro, Antonio L., Riccio, Patricia M., Richardson, Lee, Richardus, Jan Hendrik, Riederer, Anne M., Robinson, Margot, Roca, Anna, Rodriguez, Alina, Rojas-Rueda, David, Ronfani, Luca, Rothenbacher, Dietrich, Roy, Nobhojit, Ruhago, George M., Sabin, Nsanzimana, Sacco, Ralph L., Ksoreide, Kjetil, Saha, Sukanta, Sahathevan, Ramesh, Sahraian, Mohammad Ali, Sampson, Uchechukwu, Sanabria, Juan R., Sanchez-Riera, Lidia, Santos, Itamar S., Satpathy, Maheswar, Saunders, James E., Sawhney, Monika, Saylan, Mete I., Scarborough, Peter, Schoettker, Ben, Schneider, Ione J.C., Schwebel, David C., Scott, James G., Seedat, Soraya, Sepanlou, Sadaf G., Serdar, Berrin, Servan-Mori, Edson E., Shackelford, Katya, Shaheen, Amira, Shahraz, Saeid, Levy, Teresa Shamah, Shangguan, Siyi, She, Jun, Sheikhbahaei, Sara, Shepard, Donald S., Shi, Peilin, Shibuya, Kenji, Shinohara, Yukito, Shiri, Rahman, Shishani, Kawkab, Shiue, Ivy, Shrime, Mark G., Sigfusdottir, Inga D., Silberberg, Donald H., Simard, Edgar P., Sindi, Shireen, Singh, Jasvinder A., Singh, Lavanya, Skirbekk, Vegard, Sliwa, Karen, Soljak, Michael, Soneji, Samir, Soshnikov, Sergey S., Speyer, Peter, Sposato, Luciano A., Sreeramareddy, Chandrashekhar T., Stoeckl, Heidi, Stathopoulou, Vasiliki Kalliopi, Steckling, Nadine, Stein, Murray B., Stein, Dan J., Steiner, Timothy J., Stewart, Andrea, Stork, Eden, Stovner, Lars J., Stroumpoulis, Konstantino, Sturua, Lela, Sunguya, Bruno F., Swaroop, Mamta, Sykes, Bryan L., Tabb, Karen M., Takahashi, Ken, Tan, Feng, Tandon, Nikhil, Tanne, David, Tanner, Marcel, Tavakkoli, Mohammad, Taylor, Hugh R., Te Ao, Braden J., Temesgen, Awoke Misganaw, Have, Margreet Ten, Tenkorang, Eric Yeboah, Terkawi, Abdullah Sulieman, Theadom, Alice M., Thomas, Elissa, Thorne-Lyman, Andrew L., Thrift, Amanda G., Tleyjeh, Imad M., Tonelli, Marcello, Topouzis, Foti, Towbin, Jeffrey A., Toyoshima, Hideaki, Traebert, Jefferson, Tran, Bach X., Trasande, Leonardo, Trillini, Matia, Truelsen, Thoma, Trujillo, Ulise, Tsilimbaris, Miltiadi, Tuzcu, Emin M., Ukwaja, Kingsley N., Undurraga, Eduardo A., Uzun, Selen B., Van Brakel, Wim H., Van De Vijver, Steven, Dingenen, Rita Van, Van Gool, Coen H., Varakin, Yuri Y., Vasankari, Tommi J., Vavilala, Monica S., Veerman, Lennert J., Velasquez-Melendez, Gustavo, Venketasubramanian, Narayanaswamy, Vijayakumar, Lakshmi, Villalpando, Salvador, Violante, Francesco S., Vlassov, Vasiliy V., Waller, Stephen, Wallin, Mitchell T., Wan, Xia, Wang, Linhong, Wang, Jianli, Wang, Yanping, Warouw, Tati S., Weichenthal, Scott, Weiderpass, Elisabete, Weintraub, Robert G., Werdecker, Andrea, Wessells, K. Ryan, Westerman, Ronny, Wilkinson, James D., Williams, Hywel C., Williams, Thomas N., Woldeyohannes, Solomon M., Wolfe, Charles D.A., Wong, John Q., Wong, Haidong, Woolf, Anthony D., Wright, Jonathan L., Wurtz, Brittany, Xu, Gelin, Yang, Gonghuan, Yano, Yuichiro, Yenesew, Muluken A., Yentur, Gokalp K., Yip, Paul, Yonemoto, Naohiro, Yoon, Seok-Jun, Younis, Mustafa, Yu, Chuanhua, Kim, Kim Yun, Zaki, Maysaa El Sayed, Zhang, Yong, Zhao, Zheng, Zhao, Yong, Zhu, Jun, Zonies, David, Zunt, Joseph R., Salomon, Joshua A., Murray, Christopher J.L., Cell biology, Gastroenterology & Hepatology, Epidemiology, Health Technology Assessment (HTA), and Public Health
Subjects: Male, Gerontology, Nutrition and Disease, Epidemiology, years lived with disability, Global burden of disease, acute and chronic diseases, countries, Prevalence, Disease, Global Health, Medical and Health Sciences, Conduct disorder, Otitis-media, Cost of Illness, Residence Characteristics, Voeding en Ziekte, 80 and over, Global health, 2.2 Factors relating to the physical environment, 2.1 Biological and endogenous factors, countries, Aetiology, Child, Aged, 80 and over, Medicine(all), education.field_of_study, ATTENTION-DEFICIT/HYPERACTIVITY DISORDER, Incidence, Mortality rate, Incidence (epidemiology), Pain Research, Neglected Diseases, Alcohol dependence, General Medicine, Middle Aged, Global burden of disease, Global Burden of Disease Study 2013 Collaborators, Mental Health, Infectious Diseases, Attention deficit/Hyperactivity disorder, Burden of Illness, Child, Preschool, Acute Disease, Female, Life Sciences & Biomedicine, Adult, medicine.medical_specialty, Adolescent, GBD 2013, Population, acute and chronic diseases, Young Adult, Mental-disorders, Age Distribution, Medicine, General & Internal, Weights, General & Internal Medicine, medicine, Humans, Life Science, Disabled Persons, Sex Distribution, Preschool, education, Developing Countries, VLAG, Aged, Science & Technology, business.industry, Developed Countries, Cutaneous Leishmaniasis, Infant, Newborn, Infant, Health outcomes, Newborn, medicine.disease, Comorbidity, Brain Disorders, years lived with disability, Good Health and Well Being, Disease, injury, incidence, prevalence, YLDs, GBD 2010, Chronic Disease, Wounds and Injuries, business, 2.4 Surveillance and distribution, Iron-deficiency, Demography
Abstract: Summary Background Up-to-date evidence about levels and trends in disease and injury incidence, prevalence, and years lived with disability (YLDs) is an essential input into global, regional, and national health policies. In the Global Burden of Disease Study 2013 (GBD 2013), we estimated these quantities for acute and chronic diseases and injuries for 188 countries between 1990 and 2013. Methods Estimates were calculated for disease and injury incidence, prevalence, and YLDs using GBD 2010 methods with some important refinements. Results for incidence of acute disorders and prevalence of chronic disorders are new additions to the analysis. Key improvements include expansion to the cause and sequelae list, updated systematic reviews, use of detailed injury codes, improvements to the Bayesian meta-regression method (DisMod-MR), and use of severity splits for various causes. An index of data representativeness, showing data availability, was calculated for each cause and impairment during three periods globally and at the country level for 2013. In total, 35 620 distinct sources of data were used and documented to calculated estimates for 301 diseases and injuries and 2337 sequelae. The comorbidity simulation provides estimates for the number of sequelae, concurrently, by individuals by country, year, age, and sex. Disability weights were updated with the addition of new population-based survey data from four countries. Findings Disease and injury were highly prevalent; only a small fraction of individuals had no sequelae. Comorbidity rose substantially with age and in absolute terms from 1990 to 2013. Incidence of acute sequelae were predominantly infectious diseases and short-term injuries, with over 2 billion cases of upper respiratory infections and diarrhoeal disease episodes in 2013, with the notable exception of tooth pain due to permanent caries with more than 200 million incident cases in 2013. Conversely, leading chronic sequelae were largely attributable to non-communicable diseases, with prevalence estimates for asymptomatic permanent caries and tension-type headache of 2·4 billion and 1·6 billion, respectively. The distribution of the number of sequelae in populations varied widely across regions, with an expected relation between age and disease prevalence. YLDs for both sexes increased from 537·6 million in 1990 to 764·8 million in 2013 due to population growth and ageing, whereas the age-standardised rate decreased little from 114·87 per 1000 people to 110·31 per 1000 people between 1990 and 2013. Leading causes of YLDs included low back pain and major depressive disorder among the top ten causes of YLDs in every country. YLD rates per person, by major cause groups, indicated the main drivers of increases were due to musculoskeletal, mental, and substance use disorders, neurological disorders, and chronic respiratory diseases; however HIV/AIDS was a notable driver of increasing YLDs in sub-Saharan Africa. Also, the proportion of disability-adjusted life years due to YLDs increased globally from 21·1% in 1990 to 31·2% in 2013. Interpretation Ageing of the world's population is leading to a substantial increase in the numbers of individuals with sequelae of diseases and injuries. Rates of YLDs are declining much more slowly than mortality rates. The non-fatal dimensions of disease and injury will require more and more attention from health systems. The transition to non-fatal outcomes as the dominant source of burden of disease is occurring rapidly outside of sub-Saharan Africa. Our results can guide future health initiatives through examination of epidemiological trends and a better understanding of variation across countries. Funding Bill & Melinda Gates Foundation. Background Up-to-date evidence about levels and trends in disease and injury incidence, prevalence, and years lived with disability (YLDs) is an essential input into global, regional, and national health policies. In the Global Burden of Disease Study 2013 (GBD 2013), we estimated these quantities for acute and chronic diseases and injuries for 188 countries between 1990 and 2013. Methods Estimates were calculated for disease and injury incidence, prevalence, and YLDs using GBD 2010 methods with some important refinements. Results for incidence of acute disorders and prevalence of chronic disorders are new additions to the analysis. Key improvements include expansion to the cause and sequelae list, updated systematic reviews, use of detailed injury codes, improvements to the Bayesian meta-regression method (DisMod-MR), and use of severity splits for various causes. An index of data representativeness, showing data availability, was calculated for each cause and impairment during three periods globally and at the country level for 2013. In total, 35 620 distinct sources of data were used and documented to calculated estimates for 301 diseases and injuries and 2337 sequelae. The comorbidity simulation provides estimates for the number of sequelae, concurrently, by individuals by country, year, age, and sex. Disability weights were updated with the addition of new population-based survey data from four countries. Findings Disease and injury were highly prevalent; only a small fraction of individuals had no sequelae. Comorbidity rose substantially with age and in absolute terms from 1990 to 2013. Incidence of acute sequelae were predominantly infectious diseases and short-term injuries, with over 2 billion cases of upper respiratory infections and diarrhoeal disease episodes in 2013, with the notable exception of tooth pain due to permanent caries with more than 200 million incident cases in 2013. Conversely, leading chronic sequelae were largely attributable to non-communicable diseases, with prevalence estimates for asymptomatic permanent caries and tension-type headache of 2·4 billion and 1·6 billion, respectively. The distribution of the number of sequelae in populations varied widely across regions, with an expected relation between age and disease prevalence. YLDs for both sexes increased from 537·6 million in 1990 to 764·8 million in 2013 due to population growth and ageing, whereas the age-standardised rate decreased little from 114·87 per 1000 people to 110·31 per 1000 people between 1990 and 2013. Leading causes of YLDs included low back pain and major depressive disorder among the top ten causes of YLDs in every country. YLD rates per person, by major cause groups, indicated the main drivers of increases were due to musculoskeletal, mental, and substance use disorders, neurological disorders, and chronic respiratory diseases; however HIV/AIDS was a notable driver of increasing YLDs in sub-Saharan Africa. Also, the proportion of disability-adjusted life years due to YLDs increased globally from 21·1% in 1990 to 31·2% in 2013. Interpretation Ageing of the world's population is leading to a substantial increase in the numbers of individuals with sequelae of diseases and injuries. Rates of YLDs are declining much more slowly than mortality rates. The non-fatal dimensions of disease and injury will require more and more attention from health systems. The transition to non-fatal outcomes as the dominant source of burden of disease is occurring rapidly outside of sub-Saharan Africa. Our results can guide future health initiatives through examination of epidemiological trends and a better understanding of variation across countries. Funding Bill & Melinda Gates Foundation.
Published: 2015

45. Global and National Burden of Diseases and Injuries Among Children and Adolescents Between 1990 and 2013 Findings From the Global Burden of Disease 2013 Study

Author: Kyu, HH, Pinho, C, Wagner, JA, Brown, JC, Bertozzi-Villa, A, Charlson, FJ, Coffeng, LE, Dandona, L, Erskine, HE, Ferrari, AJ, Fitzmaurice, C, Fleming, TD, Forouzanfar, MH, Graetz, N, Guinovart, C, Haagsma, J, Higashi, H, Kassebaum, NJ, Larson, HJ, Lim, SS, Mokdad, AH, Moradi-Lakeh, M, Odell, SV, Roth, GA, Serina, PT, Stanaway, JD, Misganaw, A, Whiteford, HA, Wolock, TM, Hanson, SW, Abd-Allah, F, Abera, SF, Abu-Raddad, LJ, AlBuhairan, FS, Amare, AT, Antonio, CAT, Artaman, A, Barker-Collo, SL, Barrero, LH, Benjet, C, Bensenor, IM, Bhutta, ZA, Bikbov, B, Brazinova, A, Campos-Nonato, I, Castaneda-Orjuela, CA, Catala-Lopez, F, Chowdhury, R, Cooper, C, Crump, JA, Dandona, R, Degenhardt, L, Dellavalle, RP, Dharmaratne, SD, Faraon, EJA, Feigin, VL, Fuerst, T, Geleijnse, JM, Gessner, BD, Gibney, KB, Goto, A, Gunnell, D, Hankey, GJ, Hay, RJ, Hornberger, JC, Hosgood, HD, Hu, G, Jacobsen, KH, Jayaraman, SP, Jeemon, P, Jonas, JB, Karch, A, Kim, D, Kim, S, Kokubo, Y, Defo, BK, Bicer, BK, Kumar, GA, Larsson, A, Leasher, JL, Leung, R, Li, Y, Lipshultz, SE, Lopez, AD, Lotufo, PA, Lunevicius, R, Lyons, RA, Majdan, M, Malekzadeh, R, Mashal, T, Mason-Jones, AJ, Melaku, YA, Memish, ZA, Mendoza, W, Miller, TR, Mock, CN, Murray, J, Nolte, S, Oh, I-H, Olusanya, BO, Ortblad, KF, Park, E-K, Paternina Caicedo, AJ, Patten, SB, Patton, GC, Pereira, DM, Perico, N, Piel, FB, Polinder, S, Popova, S, Pourmalek, F, Quistberg, DA, Remuzzi, G, Rodriguez, A, Rojas-Rueda, D, Rothenbacher, D, Rothstein, DH, Sanabria, J, Santos, IS, Schwebel, DC, Sepanlou, SG, Shaheen, A, Shiri, R, Shiue, I, Skirbekk, V, Sliwa, K, Sreeramareddy, CT, Stein, DJ, Steiner, TJ, Stovner, LJ, Sykes, BL, Tabb, KM, Terkawi, AS, Thomson, AJ, Thorne-Lyman, AL, Towbin, JA, Ukwaja, KN, Vasankari, T, Venketasubramanian, N, Vlassov, VV, Vollset, SE, Weiderpass, E, Weintraub, RG, Werdecker, A, Wilkinson, JD, Woldeyohannes, SM, Wolfe, CDA, Yano, Y, Yip, P, Yonemoto, N, Yoon, S-J, Younis, MZ, Yu, C, Zaki, MES, Naghavi, M, Murray, CJL, Vos, T, Kyu, HH, Pinho, C, Wagner, JA, Brown, JC, Bertozzi-Villa, A, Charlson, FJ, Coffeng, LE, Dandona, L, Erskine, HE, Ferrari, AJ, Fitzmaurice, C, Fleming, TD, Forouzanfar, MH, Graetz, N, Guinovart, C, Haagsma, J, Higashi, H, Kassebaum, NJ, Larson, HJ, Lim, SS, Mokdad, AH, Moradi-Lakeh, M, Odell, SV, Roth, GA, Serina, PT, Stanaway, JD, Misganaw, A, Whiteford, HA, Wolock, TM, Hanson, SW, Abd-Allah, F, Abera, SF, Abu-Raddad, LJ, AlBuhairan, FS, Amare, AT, Antonio, CAT, Artaman, A, Barker-Collo, SL, Barrero, LH, Benjet, C, Bensenor, IM, Bhutta, ZA, Bikbov, B, Brazinova, A, Campos-Nonato, I, Castaneda-Orjuela, CA, Catala-Lopez, F, Chowdhury, R, Cooper, C, Crump, JA, Dandona, R, Degenhardt, L, Dellavalle, RP, Dharmaratne, SD, Faraon, EJA, Feigin, VL, Fuerst, T, Geleijnse, JM, Gessner, BD, Gibney, KB, Goto, A, Gunnell, D, Hankey, GJ, Hay, RJ, Hornberger, JC, Hosgood, HD, Hu, G, Jacobsen, KH, Jayaraman, SP, Jeemon, P, Jonas, JB, Karch, A, Kim, D, Kim, S, Kokubo, Y, Defo, BK, Bicer, BK, Kumar, GA, Larsson, A, Leasher, JL, Leung, R, Li, Y, Lipshultz, SE, Lopez, AD, Lotufo, PA, Lunevicius, R, Lyons, RA, Majdan, M, Malekzadeh, R, Mashal, T, Mason-Jones, AJ, Melaku, YA, Memish, ZA, Mendoza, W, Miller, TR, Mock, CN, Murray, J, Nolte, S, Oh, I-H, Olusanya, BO, Ortblad, KF, Park, E-K, Paternina Caicedo, AJ, Patten, SB, Patton, GC, Pereira, DM, Perico, N, Piel, FB, Polinder, S, Popova, S, Pourmalek, F, Quistberg, DA, Remuzzi, G, Rodriguez, A, Rojas-Rueda, D, Rothenbacher, D, Rothstein, DH, Sanabria, J, Santos, IS, Schwebel, DC, Sepanlou, SG, Shaheen, A, Shiri, R, Shiue, I, Skirbekk, V, Sliwa, K, Sreeramareddy, CT, Stein, DJ, Steiner, TJ, Stovner, LJ, Sykes, BL, Tabb, KM, Terkawi, AS, Thomson, AJ, Thorne-Lyman, AL, Towbin, JA, Ukwaja, KN, Vasankari, T, Venketasubramanian, N, Vlassov, VV, Vollset, SE, Weiderpass, E, Weintraub, RG, Werdecker, A, Wilkinson, JD, Woldeyohannes, SM, Wolfe, CDA, Yano, Y, Yip, P, Yonemoto, N, Yoon, S-J, Younis, MZ, Yu, C, Zaki, MES, Naghavi, M, Murray, CJL, and Vos, T
Abstract: IMPORTANCE: The literature focuses on mortality among children younger than 5 years. Comparable information on nonfatal health outcomes among these children and the fatal and nonfatal burden of diseases and injuries among older children and adolescents is scarce. OBJECTIVE: To determine levels and trends in the fatal and nonfatal burden of diseases and injuries among younger children (aged <5 years), older children (aged 5-9 years), and adolescents (aged 10-19 years) between 1990 and 2013 in 188 countries from the Global Burden of Disease (GBD) 2013 study. EVIDENCE REVIEW: Data from vital registration, verbal autopsy studies, maternal and child death surveillance, and other sources covering 14,244 site-years (ie, years of cause of death data by geography) from 1980 through 2013 were used to estimate cause-specific mortality. Data from 35,620 epidemiological sources were used to estimate the prevalence of the diseases and sequelae in the GBD 2013 study. Cause-specific mortality for most causes was estimated using the Cause of Death Ensemble Model strategy. For some infectious diseases (eg, HIV infection/AIDS, measles, hepatitis B) where the disease process is complex or the cause of death data were insufficient or unavailable, we used natural history models. For most nonfatal health outcomes, DisMod-MR 2.0, a Bayesian metaregression tool, was used to meta-analyze the epidemiological data to generate prevalence estimates. FINDINGS: Of the 7.7 (95% uncertainty interval [UI], 7.4-8.1) million deaths among children and adolescents globally in 2013, 6.28 million occurred among younger children, 0.48 million among older children, and 0.97 million among adolescents. In 2013, the leading causes of death were lower respiratory tract infections among younger children (905.059 deaths; 95% UI, 810,304-998,125), diarrheal diseases among older children (38,325 deaths; 95% UI, 30,365-47,678), and road injuries among adolescents (115,186 deaths; 95% UI, 105,185-124,870). Iron defici
Published: 2016

46. Estimates of global, regional, and national incidence, prevalence, and mortality of HIV, 1980-2015: the Global Burden of Disease Study 2015

Author: Wang, H, Wolock, TM, Carter, A, Nguyen, G, Kyu, HH, Gakidou, E, Hay, SI, Mills, EJ, Trickey, A, Msemburi, W, Coates, MM, Mooney, MD, Fraser, MS, Sligar, A, Salomon, J, Larson, HJ, Friedman, J, Abajobir, AA, Abate, KH, Abbas, KM, Abd El Razek, MM, Abd-Allah, F, Abdulle, AM, Abera, SF, Abubakar, I, Abu-Raddad, LJ, Abu-Rmeileh, NME, Abyu, GY, Adebiyi, AO, Adedeji, IA, Adelekan, AL, Adofo, K, Adou, AK, Ajala, ON, Akinyemiju, TF, Akseer, N, Al Lami, FH, Al-Aly, Z, Alam, K, Alam, NKM, Alasfoor, D, Aldhahri, SFS, Aldridge, RW, Alegretti, MA, Aleman, AV, Alemu, ZA, Alfonso-Cristancho, R, Ali, R, Alkerwi, A, Alla, F, Al-Raddadi, RMS, Alsharif, U, Alvarez, E, Alvis-Guzman, N, Amare, AT, Amberbir, A, Amegah, AK, Ammar, W, Amrock, SM, Antonio, CAT, Anwari, P, Arnlov, J, Al, A, Asayesh, H, Asghar, RJ, Assadi, R, Atique, S, Atkins, LS, Avokpaho, EFGA, Awasthi, A, Quintanilla, BPA, Bacha, U, Badawi, A, Barac, A, Barnighausen, T, Basu, A, Bayou, TA, Bayou, YT, Bazargan-Hejazi, S, Beardsley, J, Bedi, N, Bennett, DA, Bensenor, IM, Betsu, BD, Beyene, AS, Bhatia, E, Bhutta, ZA, Biadgilign, S, Bikbov, B, Birlik, SM, Bisanzio, D, Brainin, M, Brazinova, A, Breitborde, NJK, Brown, A, Burch, M, Butt, ZA, Campuzano, JC, Cardenas, R, Carrero, JJ, Castaneda-Orjuela, CA, Rivas, JC, Catala-Lopez, F, Chang, H-Y, Chang, J-C, Chavan, L, Chen, W, Chiang, PP-C, Chibalabala, M, Chisumpa, VH, Choi, J-YJ, Christopher, DJ, Ciobanu, LG, Cooper, C, Dahiru, T, Damtew, SA, Dandona, L, Dandona, R, das Neves, J, de Jager, P, De Leo, D, Degenhardt, L, Dellavalle, RP, Deribe, K, Deribew, A, Jarlais, DCD, Dharmaratne, SD, Ding, EL, Doshi, PP, Driscoll, TR, Dubey, M, Elshrek, YM, Elyazar, I, Endries, AY, Ermakov, SP, Eshrati, B, Esteghamati, A, Faghmous, IDA, Sofia e Sa Farinha, C, Faro, A, Farvid, MS, Farzadfar, F, Fereshtehnejad, S-M, Fernandes, JC, Fischer, F, Fitchett, JRA, Foigt, N, Fullman, N, Furst, T, Gankpe, FG, Gebre, T, Gebremedhin, AT, Gebru, AA, Geleijnse, JM, Gessner, BD, Gething, PW, Ghiwot, TT, Giroud, M, Gishu, MD, Glaser, E, Goenka, S, Goodridge, A, Gopalani, SV, Goto, A, Gugnani, HC, Guimaraes, MDC, Gupta, R, Gupta, V, Haagsma, J, Hafezi-Nejad, N, Hagan, H, Hailu, GB, Hamadeh, RR, Hamidi, S, Hammami, M, Hankey, GJ, Hao, Y, Harb, HL, Harikrishnan, S, Haro, JM, Harun, KM, Havmoeller, R, Hedayati, MT, Heredia-Pi, IB, Hoek, HW, Horino, M, Horita, N, Hosgood, HD, Hoy, DG, Hsairi, M, Hu, G, Huang, H, Huang, JJ, Iburg, KM, Idrisov, BT, Innos, K, Iyer, VJ, Jacobsen, KH, Jahanmehr, N, Jakovljevic, MB, Javanbakht, M, Jayatilleke, AU, Jeemon, P, Jha, V, Jiang, G, Jiang, Y, Jibat, T, Jonas, JB, Kabir, Z, Kamal, R, Kan, H, Karch, A, Karema, CK, Karletsos, D, Kasaeian, A, Kaul, A, Kawakami, N, Kayibanda, JF, Keiyoro, PN, Kemp, AH, Kengne, AP, Kesavachandran, CN, Khader, YS, Khalil, I, Khan, AR, Khan, EA, Khang, Y-H, Khubchandani, J, Kim, YJ, Kinfu, Y, Kivipelto, M, Kokubo, Y, Kosen, S, Koul, PA, Koyanagi, A, Defo, BK, Bicer, BK, Kulkarni, VS, Kumar, GA, Lal, DK, Lam, H, Lam, JO, Langan, SM, Lansingh, VC, Larsson, A, Leigh, J, Leung, R, Li, Y, Lim, SS, Lipshultz, SE, Liu, S, Lloyd, BK, Logroscino, G, Lotufo, PA, Lunevicius, R, Abd El Razek, HM, Mahdavi, M, Majdan, M, Majeed, A, Makhlouf, C, Malekzadeh, R, Mapoma, CC, Marcenes, W, Martinez-Raga, J, Marzan, MB, Masiye, F, Mason-Jones, AJ, Mayosi, BM, Mckee, M, Meaney, PA, Mehndiratta, MM, Mekonnen, AB, Melaku, YA, Memiah, P, Memish, ZA, Mendoza, W, Meretoja, A, Meretoja, TJ, Mhimbira, FA, Miller, TR, Mikesell, J, Mirarefin, M, Mohammad, KA, Mohammed, S, Mokdad, AH, Monasta, L, Moradi-Lakeh, M, Mori, R, Mueller, UO, Murimira, B, Murthy, GVS, Naheed, A, Naldi, L, Nangia, V, Nash, D, Nawaz, H, Nejjari, C, Ngalesoni, FN, Ngirabega, JDD, Quyen, LN, Nisar, MI, Norheim, OF, Norman, RE, Nyakarahuka, L, Ogbo, FA, Oh, I-H, Ojelabi, FA, Olusanya, BO, Olusanya, JO, Opio, JN, Oren, E, Ota, E, Padukudru, MA, Park, H-Y, Park, J-H, Patil, ST, Patten, SB, Paul, VK, Pearson, K, Peprah, EK, Pereira, DM, Perico, N, Pesudovs, K, Petzold, M, Phillips, MR, Pillay, JD, Plass, D, Polinder, S, Pourmalek, F, Prokop, DM, Qorbani, M, Rafay, A, Rahimi, K, Rahimi-Movaghar, V, Rahman, M, Rahman, MHU, Rahman, SU, Rai, RK, Rajsic, S, Ram, U, Rana, SM, Rao, PV, Remuzzi, G, Rojas-Rueda, D, Ronfani, L, Roshandel, G, Roy, A, Ruhago, GM, Saeedi, MY, Sagar, R, Saleh, MM, Sanabria, JR, Santos, IS, Sarmiento-Suarez, R, Sartorius, B, Sawhney, M, Schutte, AE, Schwebel, DC, Seedat, S, Sepanlou, SG, Servan-Mori, EE, Shaikh, MA, Sharma, R, She, J, Sheikhbahaei, S, Shen, J, Shibuya, K, Shin, HH, Sigfusdottir, ID, Silpakit, N, Santos Silva, DA, Alves Silveira, DG, Simard, EP, Sindi, S, Singh, JA, Singh, OP, Singh, PK, Skirbekk, V, Sliwa, K, Soneji, S, Sorensen, RJD, Soriano, JB, Soti, DO, Sreeramareddy, CT, Stathopoulou, V, Steel, N, Sunguya, BF, Swaminathan, S, Sykes, BL, Tabares-Seisdedos, R, Talongwa, RT, Tavakkoli, M, Taye, B, Tedla, BA, Tekle, T, Shifa, GT, Temesgen, AM, Terkawi, AS, Tesfay, FH, Tessema, GA, Thapa, K, Thomson, AJ, Thorne-Lyman, AL, Tobe-Gai, R, Topor-Madry, R, Towbin, JA, Bach, XT, Dimbuene, ZT, Tsilimparis, N, Tura, AK, Ukwaja, KN, Uneke, CJ, Uthman, OA, Venketasubramanian, N, Vladimirov, SK, Vlassov, VV, Vollset, SE, Wang, L, Weiderpass, E, Weintraub, RG, Werdecker, A, Westerman, R, Wijeratne, T, Wilkinson, JD, Wiysonge, CS, Wolfe, CDA, Won, S, Wong, JQ, Xu, G, Yadav, AK, Yakob, B, Yalew, AZ, Yano, Y, Yaseri, M, Yebyo, HG, Yip, P, Yonemoto, N, Yoon, S-J, Younis, MZ, Yu, C, Yu, S, Zaidi, Z, Zaki, MES, Zeeb, H, Zhang, H, Zhao, Y, Zodpey, S, Zoeckler, L, Zuhlke, LJ, Lopez, AD, Murray, CJL, Wang, H, Wolock, TM, Carter, A, Nguyen, G, Kyu, HH, Gakidou, E, Hay, SI, Mills, EJ, Trickey, A, Msemburi, W, Coates, MM, Mooney, MD, Fraser, MS, Sligar, A, Salomon, J, Larson, HJ, Friedman, J, Abajobir, AA, Abate, KH, Abbas, KM, Abd El Razek, MM, Abd-Allah, F, Abdulle, AM, Abera, SF, Abubakar, I, Abu-Raddad, LJ, Abu-Rmeileh, NME, Abyu, GY, Adebiyi, AO, Adedeji, IA, Adelekan, AL, Adofo, K, Adou, AK, Ajala, ON, Akinyemiju, TF, Akseer, N, Al Lami, FH, Al-Aly, Z, Alam, K, Alam, NKM, Alasfoor, D, Aldhahri, SFS, Aldridge, RW, Alegretti, MA, Aleman, AV, Alemu, ZA, Alfonso-Cristancho, R, Ali, R, Alkerwi, A, Alla, F, Al-Raddadi, RMS, Alsharif, U, Alvarez, E, Alvis-Guzman, N, Amare, AT, Amberbir, A, Amegah, AK, Ammar, W, Amrock, SM, Antonio, CAT, Anwari, P, Arnlov, J, Al, A, Asayesh, H, Asghar, RJ, Assadi, R, Atique, S, Atkins, LS, Avokpaho, EFGA, Awasthi, A, Quintanilla, BPA, Bacha, U, Badawi, A, Barac, A, Barnighausen, T, Basu, A, Bayou, TA, Bayou, YT, Bazargan-Hejazi, S, Beardsley, J, Bedi, N, Bennett, DA, Bensenor, IM, Betsu, BD, Beyene, AS, Bhatia, E, Bhutta, ZA, Biadgilign, S, Bikbov, B, Birlik, SM, Bisanzio, D, Brainin, M, Brazinova, A, Breitborde, NJK, Brown, A, Burch, M, Butt, ZA, Campuzano, JC, Cardenas, R, Carrero, JJ, Castaneda-Orjuela, CA, Rivas, JC, Catala-Lopez, F, Chang, H-Y, Chang, J-C, Chavan, L, Chen, W, Chiang, PP-C, Chibalabala, M, Chisumpa, VH, Choi, J-YJ, Christopher, DJ, Ciobanu, LG, Cooper, C, Dahiru, T, Damtew, SA, Dandona, L, Dandona, R, das Neves, J, de Jager, P, De Leo, D, Degenhardt, L, Dellavalle, RP, Deribe, K, Deribew, A, Jarlais, DCD, Dharmaratne, SD, Ding, EL, Doshi, PP, Driscoll, TR, Dubey, M, Elshrek, YM, Elyazar, I, Endries, AY, Ermakov, SP, Eshrati, B, Esteghamati, A, Faghmous, IDA, Sofia e Sa Farinha, C, Faro, A, Farvid, MS, Farzadfar, F, Fereshtehnejad, S-M, Fernandes, JC, Fischer, F, Fitchett, JRA, Foigt, N, Fullman, N, Furst, T, Gankpe, FG, Gebre, T, Gebremedhin, AT, Gebru, AA, Geleijnse, JM, Gessner, BD, Gething, PW, Ghiwot, TT, Giroud, M, Gishu, MD, Glaser, E, Goenka, S, Goodridge, A, Gopalani, SV, Goto, A, Gugnani, HC, Guimaraes, MDC, Gupta, R, Gupta, V, Haagsma, J, Hafezi-Nejad, N, Hagan, H, Hailu, GB, Hamadeh, RR, Hamidi, S, Hammami, M, Hankey, GJ, Hao, Y, Harb, HL, Harikrishnan, S, Haro, JM, Harun, KM, Havmoeller, R, Hedayati, MT, Heredia-Pi, IB, Hoek, HW, Horino, M, Horita, N, Hosgood, HD, Hoy, DG, Hsairi, M, Hu, G, Huang, H, Huang, JJ, Iburg, KM, Idrisov, BT, Innos, K, Iyer, VJ, Jacobsen, KH, Jahanmehr, N, Jakovljevic, MB, Javanbakht, M, Jayatilleke, AU, Jeemon, P, Jha, V, Jiang, G, Jiang, Y, Jibat, T, Jonas, JB, Kabir, Z, Kamal, R, Kan, H, Karch, A, Karema, CK, Karletsos, D, Kasaeian, A, Kaul, A, Kawakami, N, Kayibanda, JF, Keiyoro, PN, Kemp, AH, Kengne, AP, Kesavachandran, CN, Khader, YS, Khalil, I, Khan, AR, Khan, EA, Khang, Y-H, Khubchandani, J, Kim, YJ, Kinfu, Y, Kivipelto, M, Kokubo, Y, Kosen, S, Koul, PA, Koyanagi, A, Defo, BK, Bicer, BK, Kulkarni, VS, Kumar, GA, Lal, DK, Lam, H, Lam, JO, Langan, SM, Lansingh, VC, Larsson, A, Leigh, J, Leung, R, Li, Y, Lim, SS, Lipshultz, SE, Liu, S, Lloyd, BK, Logroscino, G, Lotufo, PA, Lunevicius, R, Abd El Razek, HM, Mahdavi, M, Majdan, M, Majeed, A, Makhlouf, C, Malekzadeh, R, Mapoma, CC, Marcenes, W, Martinez-Raga, J, Marzan, MB, Masiye, F, Mason-Jones, AJ, Mayosi, BM, Mckee, M, Meaney, PA, Mehndiratta, MM, Mekonnen, AB, Melaku, YA, Memiah, P, Memish, ZA, Mendoza, W, Meretoja, A, Meretoja, TJ, Mhimbira, FA, Miller, TR, Mikesell, J, Mirarefin, M, Mohammad, KA, Mohammed, S, Mokdad, AH, Monasta, L, Moradi-Lakeh, M, Mori, R, Mueller, UO, Murimira, B, Murthy, GVS, Naheed, A, Naldi, L, Nangia, V, Nash, D, Nawaz, H, Nejjari, C, Ngalesoni, FN, Ngirabega, JDD, Quyen, LN, Nisar, MI, Norheim, OF, Norman, RE, Nyakarahuka, L, Ogbo, FA, Oh, I-H, Ojelabi, FA, Olusanya, BO, Olusanya, JO, Opio, JN, Oren, E, Ota, E, Padukudru, MA, Park, H-Y, Park, J-H, Patil, ST, Patten, SB, Paul, VK, Pearson, K, Peprah, EK, Pereira, DM, Perico, N, Pesudovs, K, Petzold, M, Phillips, MR, Pillay, JD, Plass, D, Polinder, S, Pourmalek, F, Prokop, DM, Qorbani, M, Rafay, A, Rahimi, K, Rahimi-Movaghar, V, Rahman, M, Rahman, MHU, Rahman, SU, Rai, RK, Rajsic, S, Ram, U, Rana, SM, Rao, PV, Remuzzi, G, Rojas-Rueda, D, Ronfani, L, Roshandel, G, Roy, A, Ruhago, GM, Saeedi, MY, Sagar, R, Saleh, MM, Sanabria, JR, Santos, IS, Sarmiento-Suarez, R, Sartorius, B, Sawhney, M, Schutte, AE, Schwebel, DC, Seedat, S, Sepanlou, SG, Servan-Mori, EE, Shaikh, MA, Sharma, R, She, J, Sheikhbahaei, S, Shen, J, Shibuya, K, Shin, HH, Sigfusdottir, ID, Silpakit, N, Santos Silva, DA, Alves Silveira, DG, Simard, EP, Sindi, S, Singh, JA, Singh, OP, Singh, PK, Skirbekk, V, Sliwa, K, Soneji, S, Sorensen, RJD, Soriano, JB, Soti, DO, Sreeramareddy, CT, Stathopoulou, V, Steel, N, Sunguya, BF, Swaminathan, S, Sykes, BL, Tabares-Seisdedos, R, Talongwa, RT, Tavakkoli, M, Taye, B, Tedla, BA, Tekle, T, Shifa, GT, Temesgen, AM, Terkawi, AS, Tesfay, FH, Tessema, GA, Thapa, K, Thomson, AJ, Thorne-Lyman, AL, Tobe-Gai, R, Topor-Madry, R, Towbin, JA, Bach, XT, Dimbuene, ZT, Tsilimparis, N, Tura, AK, Ukwaja, KN, Uneke, CJ, Uthman, OA, Venketasubramanian, N, Vladimirov, SK, Vlassov, VV, Vollset, SE, Wang, L, Weiderpass, E, Weintraub, RG, Werdecker, A, Westerman, R, Wijeratne, T, Wilkinson, JD, Wiysonge, CS, Wolfe, CDA, Won, S, Wong, JQ, Xu, G, Yadav, AK, Yakob, B, Yalew, AZ, Yano, Y, Yaseri, M, Yebyo, HG, Yip, P, Yonemoto, N, Yoon, S-J, Younis, MZ, Yu, C, Yu, S, Zaidi, Z, Zaki, MES, Zeeb, H, Zhang, H, Zhao, Y, Zodpey, S, Zoeckler, L, Zuhlke, LJ, Lopez, AD, and Murray, CJL
Abstract: BACKGROUND: Timely assessment of the burden of HIV/AIDS is essential for policy setting and programme evaluation. In this report from the Global Burden of Disease Study 2015 (GBD 2015), we provide national estimates of levels and trends of HIV/AIDS incidence, prevalence, coverage of antiretroviral therapy (ART), and mortality for 195 countries and territories from 1980 to 2015. METHODS: For countries without high-quality vital registration data, we estimated prevalence and incidence with data from antenatal care clinics and population-based seroprevalence surveys, and with assumptions by age and sex on initial CD4 distribution at infection, CD4 progression rates (probability of progression from higher to lower CD4 cell-count category), on and off antiretroviral therapy (ART) mortality, and mortality from all other causes. Our estimation strategy links the GBD 2015 assessment of all-cause mortality and estimation of incidence and prevalence so that for each draw from the uncertainty distribution all assumptions used in each step are internally consistent. We estimated incidence, prevalence, and death with GBD versions of the Estimation and Projection Package (EPP) and Spectrum software originally developed by the Joint United Nations Programme on HIV/AIDS (UNAIDS). We used an open-source version of EPP and recoded Spectrum for speed, and used updated assumptions from systematic reviews of the literature and GBD demographic data. For countries with high-quality vital registration data, we developed the cohort incidence bias adjustment model to estimate HIV incidence and prevalence largely from the number of deaths caused by HIV recorded in cause-of-death statistics. We corrected these statistics for garbage coding and HIV misclassification. FINDINGS: Global HIV incidence reached its peak in 1997, at 3·3 million new infections (95% uncertainty interval [UI] 3·1-3·4 million). Annual incidence has stayed relatively constant at about 2·6 million per year (range 2·5-2·8 mi
Published: 2016

47. Lassa fever – full recovery without ribavarin treatment: a case report

Author: Ajayi, NA, primary, Ukwaja, KN, additional, Ifebunandu, NA, additional, Nnabu, R, additional, Onwe, FI, additional, and Asogun, DA, additional
Published: 2015
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48. Evaluation of inhaler techniques among asthma patients seen in Nigeria: An observational cross sectional study

Author: Onyedum, CC, primary, Desalu, OO, additional, Nwosu, NI, additional, Chukwuka, CJ, additional, Ukwaja, KN, additional, and Ezeudo, C, additional
Published: 2014
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49. Tuberculosis treatment outcome and its determinants in a tertiary care setting in south-eastern Nigeria

Author: Ukwaja, KN, primary, Ifebunandu, NA, additional, Osakwe, PC, additional, and Alobu, I, additional
Published: 2013
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50. Challenges in the management of bronchial asthma among adults in Nigeria: A systematic review

Author: Onyedum, CC, primary, Ukwaja, KN, additional, Desalu, OO, additional, and Ezeudo, C, additional
Published: 2013
Full Text: View/download PDF

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