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3. S1-Leitlinie: Lumbalpunktion und Liquordiagnostik: Zusammenfassung der Leitlinie der Deutschen Gesellschaft für Neurologie

Author

Tumani, H., Petereit, H. F., Gerritzen, A., Groß, C. C., Huss, A., Isenmann, S., Jesse, S., Khalil, M., Lewerenz, J., Leypoldt, F., Melzer, N., Meuth, S. G., Otto, M., Ruprecht, K., Sindern, E., Spreer, A., Stangel, M., Strik, H., Uhr, M., Vogelgsang, J., Wandinger, K.-P., Weber, T., Wick, M., Wildemann, B., Wiltfang, J., Woitalla, D., Zerr, I., and Zimmermann, T.

Published
2019
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5. S1 guidelines “lumbar puncture and cerebrospinal fluid analysis” (abridged and translated version)

Author

Tumani, H., Petereit, H. F., Gerritzen, A., Gross, C. C., Huss, A., Isenmann, S., Jesse, S., Khalil, M., Lewczuk, P., Lewerenz, J., Leypoldt, F., Melzer, N., Meuth, S. G., Otto, M., Ruprecht, K., Sindern, E., Spreer, A., Stangel, M., Strik, H., Uhr, M., Vogelgsang, J., Wandinger, K.-P., Weber, T., Wick, M., Wildemann, B., Wiltfang, J., Woitalla, D., Zerr, I., and Zimmermann, T.

Published
2020
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17. TMEM132D, a new candidate for anxiety phenotypes: evidence from human and mouse studies

Author

Erhardt, A, Czibere, L, Roeske, D, Lucae, S, Unschuld, P G, Ripke, S, Specht, M, Kohli, M A, Kloiber, S, Ising, M, Heck, A, Pfister, H, Zimmermann, P, Lieb, R, Pütz, B, Uhr, M, Weber, P, Deussing, J M, Gonik, M, Bunck, M, Keßler, M S, Frank, E, Hohoff, C, Domschke, K, Krakowitzky, P, Maier, W, Bandelow, B, Jacob, C, Deckert, J, Schreiber, S, Strohmaier, J, Nöthen, M, Cichon, S, Rietschel, M, Bettecken, T, Keck, M E, Landgraf, R, Müller-Myhsok, B, Holsboer, F, and Binder, E B

Published
2011
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27. Growth hormone-releasing hormone and corticotropin-releasing hormone enhance non-rapid-eye-movement sleep after sleep deprivation

Author

Schussler, P., Yassouridis, A., Uhr, M., Kluge, M., Weikel, J., Holsboer, F., and Steiger, A.

Subjects
ACTH -- Research, Peptides -- Research, Somatotropin releasing hormone -- Research, Eye -- Movements, Eye -- Research, Biological sciences
Abstract

The neuropeptides growth hormone (GH)-releasing hormone (GHRH) and corticotropin-releasing hormone (CRH) regulate sleep and nocturnal hormone secretion in a reciprocal fashion, at least in males. GHRH promotes sleep and GH and inhibits hypothalamo-pituitary-adrenocortical (HPA) hormones. CRH exerts opposite effects. In women, a sexual dimorphism was found because GHRH impairs sleep and stimulates HPA hormones. Sleep deprivation (SD) is the most powerful stimulus for inducing sleep. Studies in rodents show a key role of GHRH in sleep promotion after SD. The effects of GHRH and CRH on sleep-endocrine activity during the recovery night after SD are unknown. We compared sleep EEG, GH, and cortisol secretion between nights before and after 40 h of SD in 48 normal women and men aged 19-67 yr. During the recovery night, GHRH, CRH, or placebo were injected repetitively. After placebo during the recovery night, non-rapid-eye-movement sleep (NREMS) and rapid-eye-movement sleep (REMS) increased and wakefulness decreased compared with the baseline night. After GHRH, the increase of NREMS and the decrease of wakefulness were more distinct than after placebo. Also, after CRH, NREMS increased higher than after placebo, and a positive correlation was found between age and the baseline-related increase of slow-wave sleep. REMS increased after placebo and after GHRH, but not after CRH. EEG spectral analysis showed increases in the lower frequencies and decreases in the higher frequencies during NREMS after each of the treatments. Cortisol and GH did not differ between baseline and recovery nights after placebo. After GHRH, GH increased and cortisol decreased. Cortisol increased after CRH. No sex differences were found in these changes. Our data suggest that GHRH and CRH augment NREMS promotion after SD. Marked differences appear to exist in peptidergic sleep regulation between spontaneous and recovery sleep. event history analysis; recovery sleep; cortisol; peptides doi:10.1152/ajpendo.00641.2005

Published
2006

31. Ghrelin promotes slow-wave sleep in humans

Author

Weikel, J.C., Wichniak, A., Ising, M., Brunner, H., Friess, E., Held, K., Mathias, S., Schmid, D.A., Uhr, M., and Steiger, A.

Subjects
Ghrelin -- Physiological aspects, Somatotropin -- Physiological aspects, Hydrocortisone -- Physiological aspects, ACTH -- Physiological aspects, Prolactin -- Physiological aspects, Leptin -- Physiological aspects, Sleep -- Research, Endocrinology -- Physiological aspects, Hypothalamic-pituitary-adrenal axis -- Physiological aspects, Biological sciences
Abstract

Ghrelin, an endogenous ligand of the growth hormone (GH) secretagogue (GHS) receptor, stimulates GH release, appetite, and weight gain in humans and rodents. Synthetic GHSs modulate sleep electroencephalogram (EEG) and nocturnal hormone secretion. We studied the effect of 4 x 50 [micro]g of ghrelin administered hourly as intravenous boluses between 2200 and 0100 on sleep EEG and the secretion of plasma GH, ACTH, cortisol, prolactin, and leptin in humans (n = 7). After ghrelin administration, slow-wave sleep was increased during the total night and accumulated [delta]-wave activity was enhanced during the second half of the night. Rapid-eye-movement (REM) sleep was reduced during the second third of the night, whereas all other sleep EEG variables remained unchanged. Furthermore, GH and prolactin plasma levels were enhanced throughout the night, and cortisol levels increased during the first part of the night (2200-0300). The response of GH to ghrelin was most distinct after the first injection and lowest after the fourth injection. In contrast, cortisol showed an inverse pattern of response. Leptin levels did not differ between groups. Our data show a distinct action of exogenous ghrelin on sleep EEG and nocturnal hormone secretion. We suggest that ghrelin is an endogenous sleep-promoting factor. This role appears to be complementary to the already described effects of the peptide in the regulation of energy balance. Furthermore, ghrelin appears to be a common stimulus of the somatotropic and hypothalamo-pituitary-adrenocortical systems. It appears that ghrelin is a sleep-promoting factor in humans. growth hormone; adrenocorticotropic hormone; cortisol; prolactin; leptin; sleep endocrinology

Published
2003

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