615 results on '"Uhlig, H"'
Search Results
2. DOP55 High diagnostic accuracy of 4-probe methylation biomarkers in paediatric Inflammatory Bowel Disease by epigenome-wide analysis
- Author
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Noble, A, primary, Adams, A T, additional, Nayak, K M, additional, Kalla, R, additional, Ventham, N, additional, Cheng, G, additional, Ashton, J J, additional, Hansen, R, additional, Croft, N, additional, Wilson, D C, additional, Ennis, S, additional, Zilbauer, M, additional, Uhlig, H H, additional, and Satsangi, J, additional
- Published
- 2024
- Full Text
- View/download PDF
3. P570 Efficacy and safety of Adalimumab in Very Early-onset IBD- A Multicentre Study from the Paediatric IBD Porto Group of ESPGHAN
- Author
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Weintraub, Y, primary, Collen Veit, L, additional, Hussey, S, additional, Mitrova, K, additional, Croft, N M, additional, Kang, B, additional, Granot, M, additional, D'Arcangelo, G, additional, Spencer, E, additional, Kolho, K L, additional, Yeh, P J, additional, Sladek, M, additional, Scarallo, L, additional, Palomino Pérez, L, additional, Afzal, N, additional, de Laffolie, J, additional, Miele, E, additional, Bramuzzo, M, additional, Olén, O, additional, Russell, R, additional, Rohani, P, additional, Tzivinikos, C, additional, Urlep, D, additional, van Rheenen, P, additional, de Ridder, L, additional, Yogev, D, additional, Schneider, A M, additional, Cohen, S, additional, Garcia Romero, R, additional, Dipasquale, V, additional, Uhlig, H, additional, and Shouval S., D, additional
- Published
- 2024
- Full Text
- View/download PDF
4. A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis.
- Author
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Rivas, Manuel, Graham, Daniel, Sulem, Patrick, Stevens, Christine, Desch, A, Goyette, Philippe, Gudbjartsson, Daniel, Jonsdottir, Ingileif, Thorsteinsdottir, Unnur, Degenhardt, Frauke, Mucha, Sören, Kurki, Mitja, Li, Dalin, DAmato, Mauro, Annese, Vito, Vermeire, Severine, Weersma, Rinse, Halfvarson, Jonas, Paavola-Sakki, Paulina, Lappalainen, Maarit, Lek, Monkol, Cummings, Beryl, Tukiainen, Taru, Haritunians, Talin, Halme, Leena, Koskinen, Lotta, Ananthakrishnan, Ashwin, Luo, Yang, Heap, Graham, Visschedijk, Marijn, MacArthur, Daniel, Neale, Benjamin, Ahmad, Tariq, Anderson, Carl, Brant, Steven, Duerr, Richard, Silverberg, Mark, Cho, Judy, Palotie, Aarno, Saavalainen, Päivi, Kontula, Kimmo, Färkkilä, Martti, McGovern, Dermot, Franke, Andre, Stefansson, Kari, Rioux, John, Xavier, Ramnik, Daly, Mark, Barrett, J, de Lane, K, Edwards, C, Hart, A, Hawkey, C, Jostins, L, Kennedy, N, Lamb, C, Lee, J, Lees, C, Mansfield, J, Mathew, C, Mowatt, C, Newman, B, Nimmo, E, Parkes, M, Pollard, M, Prescott, N, Randall, J, Rice, D, Satsangi, J, Simmons, A, Tremelling, M, Uhlig, H, Wilson, D, Abraham, C, Achkar, J, Bitton, A, Boucher, G, Croitoru, K, Fleshner, P, Glas, J, Kugathasan, S, Limbergen, J, Milgrom, R, Proctor, D, Regueiro, M, Schumm, P, Sharma, Y, Stempak, J, Targan, S, and Wang, M
- Subjects
Alleles ,Colitis ,Ulcerative ,Genetic Association Studies ,Genetic Predisposition to Disease ,Genetic Testing ,Humans ,Mutation ,Protein Transport ,RNA ,Messenger ,Reproducibility of Results ,Sequence Analysis ,DNA ,Ubiquitin-Protein Ligases - Abstract
Protein-truncating variants protective against human disease provide in vivo validation of therapeutic targets. Here we used targeted sequencing to conduct a search for protein-truncating variants conferring protection against inflammatory bowel disease exploiting knowledge of common variants associated with the same disease. Through replication genotyping and imputation we found that a predicted protein-truncating variant (rs36095412, p.R179X, genotyped in 11,148 ulcerative colitis patients and 295,446 controls, MAF=up to 0.78%) in RNF186, a single-exon ring finger E3 ligase with strong colonic expression, protects against ulcerative colitis (overall P=6.89 × 10(-7), odds ratio=0.30). We further demonstrate that the truncated protein exhibits reduced expression and altered subcellular localization, suggesting the protective mechanism may reside in the loss of an interaction or function via mislocalization and/or loss of an essential transmembrane domain.
- Published
- 2016
5. Pore size distribution of MCM-41-type silica materials from pseudomorphic transformation - A minimal input data approach based on excess surface work
- Author
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Kolesnikov, A.L., Uhlig, H., Möllmer, J., Adolphs, J., Budkov, Yu. A., Georgi, N., Enke, D., and Gläser, R.
- Published
- 2017
- Full Text
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6. Bottom-up synthesis of de-functionalized and dispersible carbon spheres as colloidal adsorbent
- Author
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Balda, Maria, Mackenzie, Katrin, Woszidlo, Silke, Uhlig, H., Möllmer, J., Kopinke, Frank-Dieter, Schüürmann, Gerrit, Georgi, Anett, Balda, Maria, Mackenzie, Katrin, Woszidlo, Silke, Uhlig, H., Möllmer, J., Kopinke, Frank-Dieter, Schüürmann, Gerrit, and Georgi, Anett
- Abstract
Recent innovative adsorption technologies for water purification rely on micrometer-sized activated carbon (AC) for ultrafast adsorption or in situ remediation. In this study, the bottom-up synthesis of tailored activated carbon spheres (aCS) from sucrose as renewable feedstock is demonstrated. The synthesis is based on a hydrothermal carbonization step followed by a targeted thermal activation of the raw material. This preserves its excellent colloid properties, i.e., narrow particle size distribution around 1 µm, ideal spherical shape and excellent aqueous dispersibility. We investigated the ageing of the freshly synthesized, highly de-functionalized AC surface in air and aqueous media under conditions relevant to the practice. A slow but significant ageing due to hydrolysis and oxidation reactions was observed for all carbon samples, leading to an increase of the oxygen contents with storage time. In this study, a tailored aCS product was generated within a single pyrolysis step with 3 vol.-% H2O in N2 in order to obtain the desired pore diameters and surface properties. Adsorption characteristics, including sorption isotherms and kinetics, were investigated with monochlorobenzene (MCB) and perfluorooctanoic acid (PFOA) as adsorbates. The product showed high sorption affinities up to log (KD/[L/kg]) of 7.3 ± 0.1 for MCB and 6.2 ± 0.1 for PFOA, respectively.
- Published
- 2023
7. DOP34 Human MD2 deficiency - an inborn error of immunity predisposing to early onset Inflammatory Bowel Disease
- Author
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Li, Y, primary, Yu, Z, additional, Schenk, M, additional, Lagovsky, I, additional, Illig, D, additional, Walz, C, additional, Rohlfs, M, additional, Conca, R, additional, Muise, A, additional, Snapper, S, additional, Uhlig, H, additional, Garty, B, additional, Klein, C, additional, and Kotlarz, D, additional
- Published
- 2023
- Full Text
- View/download PDF
8. DOP02 Single cell RNA sequencing of Ulcerative Colitis and Crohn's Disease tissue samples informs the selection of Triggering Receptors Expressed on Myeloid Cells 1 (TREM1) as a target for the treatment of Inflammatory Bowel Diseases
- Author
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Grant, S, primary, Johnson, K, additional, Thomas, T, additional, Honig, G, additional, Bielecki, P, additional, Dendrou, C, additional, Guo, S, additional, Kulicke, R, additional, Li, P, additional, L'Italien, L, additional, Spies, N, additional, Stransky, N, additional, Uhlig, H, additional, Varma, M, additional, Travis, S, additional, Buckley, C, additional, and Magram, J, additional
- Published
- 2023
- Full Text
- View/download PDF
9. Chronisch-entzündliche Darmerkrankung und Immundefekte: Klinische Präsentationen und diagnostische Möglichkeiten
- Author
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Schwerd, T. and Uhlig, H. H.
- Published
- 2017
- Full Text
- View/download PDF
10. Author Correction: Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease (Nature Communications, (2020), 11, 1, (995), 10.1038/s41467-019-14275-y)
- Author
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Serra E. G., Schwerd T., Moutsianas L., Cavounidis A., Fachal L., Pandey S., Kammermeier J., Croft N. M., Posovszky C., Rodrigues A., Russell R. K., Barakat F., Auth M. K. H., Heuschkel R., Zilbauer M., Fyderek K., Braegger C., Travis S. P., Satsangi J., Parkes M., Thapar N., Ferry H., Matte J. C., Gilmour K. C., Wedrychowicz A., Sullivan P., Moore C., Sambrook J., Ouwehand W., Roberts D., Danesh J., Baeumler T. A., Fulga T. A., Carrami E. M., Ahmed A., Wilson R., Barrett J. C., Elkadri A., Griffiths A. M., Zurek M., Strisciuglio C., Elawad M., Lo B., Arancibia-Carcamo C., Bailey A., Barnes E., Bird-Lieberman E. L., Brain O., Braden B., Collier J., East J., Howarth L., Keshav S., Klenerman P., Leedham S., Palmer R., Powrie F., Simmons A., Walker M., Tolkien Z., Kaptoge S., Allen D., Mehenny S., Mant J., Di Angelantonio E., Thompson S. G., Yilmaz B., Juillerat P., Geuking M., Wiest R., Macpherson A. J., Bravo F. D., Brugger L., Carstens O., Bigler U. G., Heimgartner B., Rusticeanu M., Schmid-Uebelhart S., Strebel B., Tatu A., Tutuian R., Oyas O., Ramon C., Stelling J., Franc Y., Fournier N., Pittet V. E. H., Burnand B., Egger M., Golay D., Marot A., Musso L., Rossel J. -B., Seematter V., Sommer J., Vulliamy R., Michetti P., Maillard M. H., Keller C., Nydegger A., Schoepfe A., Archanioti E., Ezri J., Fraga M., Schoepfer A., Muller C., Rogler G., Biedermann L., Blattmann M., Burk S., Dora B., Fried M., Misselwitz B., Mullhaupt B., Obialo N., Pohl D., Raschle N., Scharl M., Vavricka S., Von Kanel R., Zeitz J., Abdelrahman K., Ademi G., Borovicka J., Brand S., Frei R., Haarer J., Knellwolf-Grieger C., Krieger-Grubel C., Kunzler P., Meyenberger C., Meyer P., Rohrich N., Sawatzki M., Schelling M., Semadeni G. -M., Sulz M., Zimmermann D., Aepli P., Criblez D. H., Hess C., Richterich J. -P., Spalinger J., Staudenmann D., Stulz A., Wohrle S., Thomas A., Anderegg C., Kohler H., Kusche R., Antonino A. -T., Arrigoni E., Bengoa J. M., Cunningham S., de Saussure P., Girard L., de Jong D. B., Basturk P., Brunner S., Degen L., Hruz P., Bakker C. K. -D., Niess J., Balsiger B., Haldemann J., Saner G., Seibold F., Bauerfeind P., Becocci A., Belli D., Binek J., Hengstler P., Boehm S., Boldanov T., Buhr P., Koller R., Rueger V., Senning A., Burri E., Buyse S., Cao D. -T., D'Angelo F., Delarive J., Doerig C., Hessler R., Preissler C., Rentsch R., Risti B., Ritz M. A., Steuerwald M., Vogtlin J., Sagmeister M., Sauter B., Schibli S., Sokollik C., Schlauri H., Schnegg J. -F., Seirafi M., Spangenberger H., Stadler P., Staub P., Stenz V., Tempia-Caliera M., Thorens J., Truninger K., Urfer P., Viani F., Vouillamoz D., Zander S., Wyli T., Jostins L., Kennedy N. A., Ahmad T., Lamb C. A., Edwards C., Hart A., Hawkey C., Mansfield J. C., Mowat C., Newman W. G., Tremelling M., Lee J. C., Prescott N. J., Mathew C. G., Lees C. W., McGovern D. P. B., Targan S. R., Botwin G., Mengesha E., Fleshner P., Landers C., Li D., Rioux J. D., Bitton A., Cote-Daigneault J., Daly M. J., Xavier R., Morris K., Boucher G., Cho J. H., Abraham C., Merad M., Sands B., Peter I., Hao K., Itan Y., Duerr R. H., Konnikova L., Schwartz M. B., Proksell S., Johnston E., Miladinova V., Chen W., Brant S. R., Datta L., Silverberg M. S., Schumm L. P., Birch S., Giri M., Gettler K., Sharma Y., Stevens C., Lazarev M., Haritunians T., Snapper S. B., Shah N., Muise A. M., Wilson D. C., Uhlig H. H., Anderson C. A., Serra, E. G., Schwerd, T., Moutsianas, L., Cavounidis, A., Fachal, L., Pandey, S., Kammermeier, J., Croft, N. M., Posovszky, C., Rodrigues, A., Russell, R. K., Barakat, F., Auth, M. K. H., Heuschkel, R., Zilbauer, M., Fyderek, K., Braegger, C., Travis, S. P., Satsangi, J., Parkes, M., Thapar, N., Ferry, H., Matte, J. C., Gilmour, K. C., Wedrychowicz, A., Sullivan, P., Moore, C., Sambrook, J., Ouwehand, W., Roberts, D., Danesh, J., Baeumler, T. A., Fulga, T. A., Carrami, E. M., Ahmed, A., Wilson, R., Barrett, J. C., Elkadri, A., Griffiths, A. M., Zurek, M., Strisciuglio, C., Elawad, M., Lo, B., Arancibia-Carcamo, C., Bailey, A., Barnes, E., Bird-Lieberman, E. L., Brain, O., Braden, B., Collier, J., East, J., Howarth, L., Keshav, S., Klenerman, P., Leedham, S., Palmer, R., Powrie, F., Simmons, A., Walker, M., Tolkien, Z., Kaptoge, S., Allen, D., Mehenny, S., Mant, J., Di Angelantonio, E., Thompson, S. G., Yilmaz, B., Juillerat, P., Geuking, M., Wiest, R., Macpherson, A. J., Bravo, F. D., Brugger, L., Carstens, O., Bigler, U. G., Heimgartner, B., Rusticeanu, M., Schmid-Uebelhart, S., Strebel, B., Tatu, A., Tutuian, R., Oyas, O., Ramon, C., Stelling, J., Franc, Y., Fournier, N., Pittet, V. E. H., Burnand, B., Egger, M., Golay, D., Marot, A., Musso, L., Rossel, J. -B., Seematter, V., Sommer, J., Vulliamy, R., Michetti, P., Maillard, M. H., Keller, C., Nydegger, A., Schoepfe, A., Archanioti, E., Ezri, J., Fraga, M., Schoepfer, A., Muller, C., Rogler, G., Biedermann, L., Blattmann, M., Burk, S., Dora, B., Fried, M., Misselwitz, B., Mullhaupt, B., Obialo, N., Pohl, D., Raschle, N., Scharl, M., Vavricka, S., Von Kanel, R., Zeitz, J., Abdelrahman, K., Ademi, G., Borovicka, J., Brand, S., Frei, R., Haarer, J., Knellwolf-Grieger, C., Krieger-Grubel, C., Kunzler, P., Meyenberger, C., Meyer, P., Rohrich, N., Sawatzki, M., Schelling, M., Semadeni, G. -M., Sulz, M., Zimmermann, D., Aepli, P., Criblez, D. H., Hess, C., Richterich, J. -P., Spalinger, J., Staudenmann, D., Stulz, A., Wohrle, S., Thomas, A., Anderegg, C., Kohler, H., Kusche, R., Antonino, A. -T., Arrigoni, E., Bengoa, J. M., Cunningham, S., de Saussure, P., Girard, L., de Jong, D. B., Basturk, P., Brunner, S., Degen, L., Hruz, P., Bakker, C. K. -D., Niess, J., Balsiger, B., Haldemann, J., Saner, G., Seibold, F., Bauerfeind, P., Becocci, A., Belli, D., Binek, J., Hengstler, P., Boehm, S., Boldanov, T., Buhr, P., Koller, R., Rueger, V., Senning, A., Burri, E., Buyse, S., Cao, D. -T., D'Angelo, F., Delarive, J., Doerig, C., Hessler, R., Preissler, C., Rentsch, R., Risti, B., Ritz, M. A., Steuerwald, M., Vogtlin, J., Sagmeister, M., Sauter, B., Schibli, S., Sokollik, C., Schlauri, H., Schnegg, J. -F., Seirafi, M., Spangenberger, H., Stadler, P., Staub, P., Stenz, V., Tempia-Caliera, M., Thorens, J., Truninger, K., Urfer, P., Viani, F., Vouillamoz, D., Zander, S., Wyli, T., Jostins, L., Kennedy, N. A., Ahmad, T., Lamb, C. A., Edwards, C., Hart, A., Hawkey, C., Mansfield, J. C., Mowat, C., Newman, W. G., Tremelling, M., Lee, J. C., Prescott, N. J., Mathew, C. G., Lees, C. W., Mcgovern, D. P. B., Targan, S. R., Botwin, G., Mengesha, E., Fleshner, P., Landers, C., Li, D., Rioux, J. D., Bitton, A., Cote-Daigneault, J., Daly, M. J., Xavier, R., Morris, K., Boucher, G., Cho, J. H., Abraham, C., Merad, M., Sands, B., Peter, I., Hao, K., Itan, Y., Duerr, R. H., Konnikova, L., Schwartz, M. B., Proksell, S., Johnston, E., Miladinova, V., Chen, W., Brant, S. R., Datta, L., Silverberg, M. S., Schumm, L. P., Birch, S., Giri, M., Gettler, K., Sharma, Y., Stevens, C., Lazarev, M., Haritunians, T., Snapper, S. B., Shah, N., Muise, A. M., Wilson, D. C., Uhlig, H. H., and Anderson, C. A.
- Published
- 2022
11. Technische Sicherheit von elektromedizinischen Geräten und Systemen in medizinisch genutzten Räumen
- Author
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Kramme, R., Uhlig, H. -P., and Kramme, Rüdiger, editor
- Published
- 2007
- Full Text
- View/download PDF
12. Automated annotator: capturing expert knowledge for free
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Elmes, S, Chakraborti, T, Fan, M, Uhlig, H, and Rittscher, J
- Subjects
Automation ,Histology ,Data Curation - Abstract
Deep learning enabled medical image analysis is heavily reliant on expert annotations which is costly. We present a simple yet effective automated annotation pipeline that uses autoencoder based heatmaps to exploit high level information that can be extracted from a histology viewer in an unobtrusive fashion. By predicting heatmaps on unseen images the model effectively acts like a robot annotator. The method is demonstrated in the context of coeliac disease histology images in this initial work, but the approach is task agnostic and may be used for other medical image annotation applications. The results are evaluated by a pathologist and also empirically using a deep network for coeliac disease classification. Initial results using this simple but effective approach are encouraging and merit further investigation, specially considering the possibility of scaling this up to a large number of users.
- Published
- 2022
13. P414 Vedolizumab in Pediatric inflammatory bowel diseases: a retrospective multi-center experience from the paediatric IBD Porto group of ESPGHAN
- Author
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Ledder, O., de Meij, T., Martín de Carpi, J., Richmond, L., Cohen, S., Bronsky, J., Shaoul, R., Levine, A., Escher, J., deRidder, L., Assa, A., Ruemmele, F., Shah, N., Wolters, V., Rodrigues, A., Uhlig, H., Urlep, D., Posovsky, C., Kolho, K., and Turner, D.
- Published
- 2017
- Full Text
- View/download PDF
14. Housing and Credit Markets
- Author
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Guerrieri, V., primary and Uhlig, H., additional
- Published
- 2016
- Full Text
- View/download PDF
15. Anwendung von Enzymen in der Lebensmitteltechnik
- Author
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Uhlig, H. and Osteroth, Dieter, editor
- Published
- 1991
- Full Text
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16. Training der wirbelsäulenstabilisierenden Muskulatur
- Author
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Denner, A., Uhlig, H., Imhoff, A. B., editor, and Imhoff, Andreas B., editor
- Published
- 1999
- Full Text
- View/download PDF
17. Clinical genomics for the diagnosis of monogenic forms of inflammatory bowel disease
- Author
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Uhlig, H, Charbit-Henrion, F, Kotlarz, D, Shouval, D, Schwerd, T, Strisciuglio, C, de Ridder, L, van Limbergen, J, Macchia, L, Snapper, SB, Rummele, FM, Wilson, DC, Travis, SPL, Griffiths, AM, Turner, D, Klein, C, Muise, AM, Russell, RK, and ESPGHAN, Paediatric IBD Porto Group of
- Abstract
Background: It is important to identify patients with monogenic IBD since management may differ from classical IBD. In this position statement we formulate recommendations for the use of genomics in evaluating potential monogenic causes of IBD across age groups. Methods: The consensus included paediatric IBD specialists from the Paediatric IBD Porto group of the European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) and specialists from several monogenic IBD research consortia. We defined key topics and performed a systematic literature review to cover indications, technologies (targeted panel, exome and genome sequencing), gene panel setup, cost-effectiveness of genetic screening, and requirements for the clinical care setting. We developed recommendations that were voted upon by all authors and Porto group members (32 voting specialists). Results: We recommend next-generation DNA sequencing technologies to diagnose monogenic causes of IBD in routine clinical practice embedded in a setting of multidisciplinary patient care. Routine genetic screening is not recommended for all IBD patients. Genetic testing should be considered depending on age of IBD onset (infantile IBD, very early onset IBD, paediatric or young adult IBD) and further criteria such as family history, relevant comorbidities and extraintestinal manifestations. Genetic testing is also recommended in advance of hematopoietic stem cell transplantation. We develop a diagnostic algorithm that includes a gene panel of seventy-five monogenic IBD genes. Considerations are provided also for low resource countries. Summary: Genomic technologies should be considered an integral part of patient care to investigate patients at risk for monogenic forms of IBD.
- Published
- 2021
18. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
- Author
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Klionsky D, Abdel-Aziz A, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard M, Abudu Y, Acevedo-Arozena A, Adamopoulos I, Adeli K, Adolph T, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal B, Agnello M, Agostinis P, Agrewala J, Agrotis A, Aguilar P, Ahmad S, Ahmed Z, Ahumada-Castro U, Aits S, Aizawa S, Akkoc Y, Akoumianaki T, Akpinar H, Al-Abd A, Al-Akra L, Al-Gharaibeh A, Alaoui-Jamali M, Alberti S, Alcocer-Gomez E, Alessandri C, Ali M, Al-Bari M, Aliwaini S, Alizadeh J, Almacellas E, Almasan A, Alonso A, Alonso G, Altan-Bonnet N, Altieri D, Alves S, da Costa C, Alzaharna M, Amadio M, Amantini C, Amaral C, Ambrosio S, Amer A, Ammanathan V, An Z, Andersen S, Andrabi S, Andrade-Silva M, Andres A, Angelini S, Ann D, Anozie U, Ansari M, Antas P, Antebi A, Anton Z, Anwar T, Apetoh L, Apostolova N, Araki T, Araki Y, Arasaki K, Araujo W, Araya J, Arden C, Arevalo M, Arguelles S, Arias E, Arikkath J, Arimoto H, Ariosa A, Armstrong-James D, Arnaune-Pelloquin L, Aroca A, Arroyo D, Arsov I, Artero R, Asaro D, Aschner M, Ashrafizadeh M, Ashur-Fabian O, Atanasov A, Au A, Auberger P, Auner H, Aurelian L, Autelli R, Avagliano L, Avalos Y, Aveic S, Aveleira C, AvinWittenberg T, Aydin Y, Ayton S, Ayyadevara S, Azzopardi M, Baba M, Backer J, Backues S, Bae D, Bae O, Bae S, Baehrecke E, Baek A, Baek S, Bagetta G, Bagniewska-Zadworna A, Bai H, Bai J, Bai X, Bai Y, Bairagi N, Baksi S, Balbi T, Baldari C, Balduini W, Ballabio A, Ballester M, Balazadeh S, Balzan R, Bandopadhyay R, Banerjee S, Bao Y, Baptista M, Baracca A, Barbati C, Bargiela A, Barila D, Barlow P, Barmada S, Barreiro E, Barreto G, Bartek J, Bartel B, Bartolome A, Barve G, Basagoudanavar S, Bassham D, Jr R, Basu A, Batoko H, Batten I, Baulieu E, Baumgarner B, Bayry J, Beale R, Beau I, Beaumatin F, Bechara L, Beck G, Beers M, Begun J, Behrends C, Behrens G, Bei R, Bejarano E, Bel S, Behl C, Belaid A, Belgareh-Touze N, Bellarosa C, Belleudi F, Perez M, Bello-Morales R, Beltran J, Beltran S, Benbrook D, Bendorius M, Benitez B, Benito-Cuesta I, Bensalem J, Berchtold M, Berezowska S, Bergamaschi D, Bergami M, Bergmann A, Berliocchi L, Berlioz-Torrent C, Bernard A, Berthoux L, Besirli C, Besteiro S, Betin V, Beyaert R, Bezbradica J, Bhaskar K, Bhatia-Kissova I, Bhattacharya R, Bhattacharya S, Bhattacharyya S, Bhuiyan M, Bhutia S, Bi L, Bi X, Biden T, Bijian K, Billes V, Binart N, Bincoletto C, Birgisdottir A, Bjorkoy G, Blanco G, Blas-Garcia A, Blasiak J, Blomgran R, Blomgren K, Blum J, Boada-Romero E, Boban M, BoeszeBattaglia K, Boeuf P, Boland B, Bomont P, Bonaldo P, Bonam S, Bonfili L, Bonifacino J, Boone B, Bootman M, Bordi M, Borner C, Bornhauser B, Borthakur G, Bosch J, Bose S, Botana L, Botas J, Boulanger C, Boulton M, Bourdenx M, Bourgeois B, Bourke N, Bousquet G, Boya P, Bozhkov P, Bozi L, Bozkurt T, Brackney D, Brandts C, Braun R, Braus G, Bravo-Sagua R, Bravo-San Pedro J, Brest P, Bringer M, Briones-Herrera A, Broaddus V, Brodersen P, Alvarez E, Brodsky J, Brody S, Bronson 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flux ,macroautophagy ,phagophore ,stress ,vacuole ,Autophagosome ,LC3 ,lysosome ,neurodegeneration ,cancer - Abstract
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field.
- Published
- 2021
19. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
- Author
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Werner, Brand-Saberi, Beate, Dong, X Charlie, Kenchappa, Chandra Shekar, Li, Zuguo, Lin, Yong, Oshima, Shigeru, Rong, Yueguang, Sluimer, Judith C, Stallings, Christina L, and Tong, Chun-Kit
- Abstract
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field.
- Published
- 2021
20. Privacy in Digital Payments—Escaping the Panopticon
- Author
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Uhlig, Harald, Alonso, Mike, and Frost, Jon
- Published
- 2023
- Full Text
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21. Cells of the human intestinal tract mapped across space and time
- Author
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Elmentaite, R, primary, Kumasaka, N, additional, King, HW, additional, Roberts, K, additional, Dabrowska, M, additional, Pritchard, S, additional, Bolt, L, additional, Vieira, SF, additional, Mamanova, L, additional, Huang, N, additional, Goh Kai’En, I, additional, Stephenson, E, additional, Engelbert, J, additional, Botting, RA, additional, Fleming, A, additional, Dann, E, additional, Lisgo, SN, additional, Katan, M, additional, Leonard, S, additional, Oliver, TRW, additional, Hook, CE, additional, Nayak, K, additional, Perrone, F, additional, Campos, LS, additional, Dominguez-Conde, C, additional, Polanski, K, additional, Van Dongen, S, additional, Patel, M, additional, Morgan, MD, additional, Marioni, JC, additional, Bayraktar, OA, additional, Meyer, KB, additional, Zilbauer, M, additional, Uhlig, H, additional, Clatworthy, MR, additional, Mahbubani, KT, additional, Saeb Parsy, K, additional, Haniffa, M, additional, James, KR, additional, and Teichmann, SA, additional
- Published
- 2021
- Full Text
- View/download PDF
22. Analyse des Serumzinkspiegels bei Patienten mit atopischer Dermatitis, Psoriasis vulgaris und bei Hautgesunden
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Kreft, B., Wohlrab, J., Fischer, M., Uhlig, H., Skölziger, R., and Marsch, W.C.
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- 2000
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23. Die Rekonditionierbarkeit chronischer Rückenpatienten mit muskulärer Insuffizienz
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Uhlig, H.
- Published
- 1999
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24. A39 NOVEL GAIN OF FUNCTION NON-RECEPTOR TYROSINE KINASE MUTATIONS ARE LINKED TO THE PATHOGENESIS OF VEOIBD
- Author
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Mehta, M, primary, Wang, L, primary, Guo, C, primary, Warner, N, primary, Li, Q, primary, Pan, J, primary, Boztug, K, primary, Uhlig, H, primary, and Muise, A, primary
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- 2020
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25. Dairy products, probiotics and the health of infants and children
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Lükewille, U, primary and Uhlig, H, additional
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- 2007
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26. NOX1 loss-of-function genetic variants in patients with inflammatory bowel disease
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Schwerd, T., Bryant, R. V., Pandey, S., Capitani, M., Meran, L., Cazier, J. -B., Jung, J., Mondal, K., Parkes, M., Mathew, C. G., Fiedler, K., McCarthy, D. J., Sullivan, P. B., Rodrigues, A., Travis, S. P. L., Moore, C., Sambrook, J., Ouwehand, W. H., Roberts, D. J., Danesh, J., Russell, R. K., Wilson, D. C., Kelsen, J. R., Cornall, R., Denson, L. A., Kugathasan, S., Knaus, U. G., Serra, E. G., Anderson, C. A., Duerr, R. H., McGovern, D. P. B., Cho, J., Powrie, Fiona, Li, V. S. W., Muise, A. M., Uhlig, H. H., Donnelly, P., Bell, J., Bentley, D., McVean, G., Ratcliffe, P., Taylor, J., Wilkie, A. O. M., Broxholme, J., Buck, D., Gregory, L., Gregory, J., Lunter, G., Tomlinson, I., Allan, C., Attar, M., Green, A., Humphray, S., Kingsbury, Z., Lamble, S., Lonie, L., Pagnamenta, A., Piazza, P., Polanco, G., Trebes, A., Copley, R., Fiddy, S., Grocock, R., Hatton, E., Holmes, C., Hughes, L., Humburg, P., Kanapin, A., Lise, S., Martin, H., Murray, L., McCarthy, D., Rimmer, A., Sahgal, N., Wright, B., Yau, C., Arancibia, Carolina, Bailey, Adam, Barnes, Ellie, Bird-Lieberman, Beth, Brain, Oliver, Braden, Barbara, Collier, Jane, East, James, Geremia, Alessandra, Howarth, Lucy, Keshav, Satish, Klenerman, Paul, Leedham, Simon, Palmer, Rebecca, Rodrigues, Astor, Simmons, Alison, Sullivan, Peter B, Travis, Simon P L, Uhlig, Holm H, Heuschkel, Rob, Zilbauer, Matthias, Auth, Marcus K. H., Shah, Neil, Kammermeier, Jochen, Croft, Nick, Barakat, Farah, Russell, Richard K., Wilson, David C., Henderson, Paul, Braegger, Christian P., Posovszky, Carsten, Fyderek, Krzysztof, Wedrychowicz, Andrzej, Zurek, Marlen, Strisciuglio, Caterina, Elawad, Mamoun, Lo, Bernice, Parkes, Miles, Satsangi, Jack, Anderson, Carl A., Jostins, L., Kennedy, N. A., Lamb, C. A., Ahmad, T., Edwards, C., Hart, A., Hawkey, C., Mansfield, J. C., Mowat, C., Newman, W. G., Satsangi, J., Simmons, A., Tremelling, M., Lee, J. C., Prescott, N. J., Lees, C. W., Barrett, J. C., UK IBD Genetics Consortium, COLORS in IBD, Oxford IBD cohort study investigators, WGS500 Consortium, INTERVAL Study, Schwerd, T., Bryant, R. V., Pandey, S., Capitani, M., Meran, L., Cazier, J. -B., Jung, J., Mondal, K., Parkes, M., Mathew, C. G., Fiedler, K., Mccarthy, D. J., Sullivan, P. B., Rodrigues, A., Travis, S. P. L., Moore, C., Sambrook, J., Ouwehand, W. H., Roberts, D. J., Danesh, J., Russell, R. K., Wilson, D. C., Kelsen, J. R., Cornall, R., Denson, L. A., Kugathasan, S., Knaus, U. G., Serra, E. G., Anderson, C. A., Duerr, R. H., Mcgovern, D. P. B., Cho, J., Powrie, Fiona, Li, V. S. W., Muise, A. M., Uhlig, H. H., Donnelly, P., Bell, J., Bentley, D., Mcvean, G., Ratcliffe, P., Taylor, J., Wilkie, A. O. M., Broxholme, J., Buck, D., Gregory, L., Gregory, J., Lunter, G., Tomlinson, I., Allan, C., Attar, M., Green, A., Humphray, S., Kingsbury, Z., Lamble, S., Lonie, L., Pagnamenta, A., Piazza, P., Polanco, G., Trebes, A., Copley, R., Fiddy, S., Grocock, R., Hatton, E., Holmes, C., Hughes, L., Humburg, P., Kanapin, A., Lise, S., Martin, H., Murray, L., Mccarthy, D., Rimmer, A., Sahgal, N., Wright, B., Yau, C., Arancibia, Carolina, Bailey, Adam, Barnes, Ellie, Bird-Lieberman, Beth, Brain, Oliver, Braden, Barbara, Collier, Jane, East, Jame, Geremia, Alessandra, Howarth, Lucy, Keshav, Satish, Klenerman, Paul, Leedham, Simon, Palmer, Rebecca, Rodrigues, Astor, Simmons, Alison, Sullivan, Peter B, Travis, Simon P L, Uhlig, Holm H, Heuschkel, Rob, Zilbauer, Matthia, Auth, Marcus K. H., Shah, Neil, Kammermeier, Jochen, Croft, Nick, Barakat, Farah, Russell, Richard K., Wilson, David C., Henderson, Paul, Braegger, Christian P., Posovszky, Carsten, Fyderek, Krzysztof, Wedrychowicz, Andrzej, Zurek, Marlen, Strisciuglio, Caterina, Elawad, Mamoun, Lo, Bernice, Parkes, Mile, Satsangi, Jack, Anderson, Carl A., Jostins, L., Kennedy, N. A., Lamb, C. A., Ahmad, T., Edwards, C., Hart, A., Hawkey, C., Mansfield, J. C., Mowat, C., Newman, W. G., Satsangi, J., Simmons, A., Tremelling, M., Lee, J. C., Prescott, N. J., Lees, C. W., Barrett, J. C., UK IBD Genetics, Consortium, COLORS in, Ibd, Oxford IBD cohort study, Investigator, Wgs500, Consortium, and Interval, Study
- Subjects
Male ,Genotype ,Colon ,Immunology ,Mutation, Missense ,Genetic Association Studie ,Polymorphism, Single Nucleotide ,Article ,Mice ,Animals ,Humans ,Immunology and Allergy ,Genetic Predisposition to Disease ,Child ,Genetic Association Studies ,Genes, Modifier ,Genome ,Animal ,Inflammatory Bowel Disease ,High-Throughput Nucleotide Sequencing ,Inflammatory Bowel Diseases ,digestive system diseases ,Host-Pathogen Interaction ,Mice, Inbred C57BL ,Child, Preschool ,Host-Pathogen Interactions ,NADPH Oxidase 1 ,Reactive Oxygen Species ,Reactive Oxygen Specie ,Human - Abstract
Genetic defects that affect intestinal epithelial barrier function can present with very early-onset inflammatory bowel disease (VEOIBD). Using whole-genome sequencing, a novel hemizygous defect in NOX1 encoding NAPDH oxidase 1 was identified in a patient with ulcerative colitis-like VEOIBD. Exome screening of 1,878 pediatric patients identified further seven male inflammatory bowel disease (IBD) patients with rare NOX1 mutations. Loss-of-function was validated in p.N122H and p.T497A, and to a lesser degree in p.Y470H, p.R287Q, p.I67M, p.Q293R as well as the previously described p.P330S, and the common NOX1 SNP p.D360N (rs34688635) variant. The missense mutation p.N122H abrogated reactive oxygen species (ROS) production in cell lines, ex vivo colonic explants, and patient-derived colonic organoid cultures. Within colonic crypts, NOX1 constitutively generates a high level of ROS in the crypt lumen. Analysis of 9,513 controls and 11,140 IBD patients of non-Jewish European ancestry did not reveal an association between p.D360N and IBD. Our data suggest that loss-of-function variants in NOX1 do not cause a Mendelian disorder of high penetrance but are a context-specific modifier. Our results implicate that variants in NOX1 change brush border ROS within colonic crypts at the interface between the epithelium and luminal microbes.
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- 2018
27. Janus kinase inhibition for autoinflammation in DNASE2 deficiency
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Hong, Y, Capitani, M, Murphy, C, Pandey, S, Cavounidis, A, Takeshita, H, Nanthapisal, S, Yasuda, T, Bader-Meunier, B, McCreary, D, Omoyinmi, E, Rao, A, Booth, C, Gilmour, K, Sebire, N, Shah, N, Klein, N, Bullock, A, Eleftheriou, D, Uhlig, H, and Brogan, P
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- 2019
28. The short chain fatty acid butyrate imprints an antimicrobial program in macrophages
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Schulthess, J, Pandey, S, Capitani, M, Rue-Albrecht, K, Arnold, I, Franchini, F, Chomka, A, Ilott, N, Johnston, D, Pires, E, McCullagh, J, Sansom, S, Arancibia-Carcamo, C, Uhlig, H, and Powrie, F
- Subjects
Colon ,Microbiota ,Macrophages ,Cell Differentiation ,Fatty Acids, Volatile ,Monocytes ,Article ,Intestines ,Mice, Inbred C57BL ,Butyrates ,Gene Expression Regulation ,Anti-Infective Agents ,Animals ,Cytokines ,Dysbiosis ,Humans ,Cells, Cultured - Abstract
Summary Host microbial cross-talk is essential to maintain intestinal homeostasis. However, maladaptation of this response through microbial dysbiosis or defective host defense toward invasive intestinal bacteria can result in chronic inflammation. We have shown that macrophages differentiated in the presence of the bacterial metabolite butyrate display enhanced antimicrobial activity. Butyrate-induced antimicrobial activity was associated with a shift in macrophage metabolism, a reduction in mTOR kinase activity, increased LC3-associated host defense and anti-microbial peptide production in the absence of an increased inflammatory cytokine response. Butyrate drove this monocyte to macrophage differentiation program through histone deacetylase 3 (HDAC3) inhibition. Administration of butyrate induced antimicrobial activity in intestinal macrophages in vivo and increased resistance to enteropathogens. Our data suggest that (1) increased intestinal butyrate might represent a strategy to bolster host defense without tissue damaging inflammation and (2) that pharmacological HDAC3 inhibition might drive selective macrophage functions toward antimicrobial host defense., Graphical Abstract, Highlights • Butyrate induces differentiation of macrophages with potent antimicrobial function • Enhanced antimicrobial function is a consequence of glycolysis and mTOR inhibition • Single-cell RNA-sequencing identifies butyrate-induced antimicrobial peptides • Butyrate inhibits HDAC3 to drive metabolic changes and microbicidal function, Macrophages maintain gut homeostasis by eliminating invasive pathogens and regulating inflammatory responses. Schulthess et al. demonstrate that butyrate, a bacterial fermentation product, imprints potent antimicrobial activity during macrophage differentiation through HDAC3i function.
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- 2019
29. Local order of polymer derived amorphous SixCyNz
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Uhlig, H., Friess, M., Lamparter, P., and Steeb, S.
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Amorphous substances -- Observations ,Polymers -- Research ,Diffraction -- Usage ,Physics - Abstract
The local order of an a-Si(sub39)C(sub61), a-Si(sub40)C(sub24)N(sub36) and a-Si(sub26)C(sub40)N(sub34), polymer derived amorphous ceramics, is reported. X-ray diffraction was used to obtain total structure factors and pair correlation functions. All materials showed a distinct short range order. A stoichiometric amorphous SiC phase was formed in A-Si(sub39)C(sub61), besides the amorphous carbon phase. Phase separation into two amorphous phases was seen in the case of a-Si(sub40)C(sub24)N(sub36) and a-Si(sub26)C(sub40)N(sub34).
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- 1998
30. Evaluation of Citrus Tristeza Virus Tolerant Rootstocks Grafted with Valencia Orange in Venezuela
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Mendt, R., Ochoa, F., Villalba, L., Uhlig, H., Perez, G., Cedeiio, A., and Barreto, T.
- Published
- 1988
31. Untersuchungen zu Mikrosatelliten-Instabilitäten bei Colitis ulcerosa
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Uhlig, H., primary, Göbel, U., additional, Kasperk, R., additional, Büttner, R., additional, and Schumpelick, V., additional
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- 2000
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32. CD103 in intestinal immune regulation: 9.1
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Coombes, J., Annacker, O., Malmstrom, V., Uhlig, H., Bourne, T., Parker, C. M., and Powrie, F.
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- 2004
33. Langzeitergebnisse der Chirurgischen Therapie bei Morbus Crohn
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Uhlig, H., primary, Riesener, K.-P., additional, Döring, S., additional, and Schumpelick, V., additional
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- 1999
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34. Participation of gut commensal bacteria and mucosal immunity in pathogenesis of inflammatory bowel disease (IBD): gnotobiotic models of human disease
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Tlaskalová-Hogenová, H., Stepankova, R., Kozakova, H., Tuckova, L., Sokol, D., Cukrowska, B., Hudcovic, T., Rehakova, Z., Hrncir, T., Heczko, P., Strus, M., Uhlig, H., Powrie, F., and Bland, P.
- Published
- 2004
35. Histopathological Parameters of Helicobacter pylori-associated Gastritis in Children and Adolescents: Comparison with Findings in Adults
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Uhlig, H H., Tannapfel, A, Mössner, J, Jedwilayties, S, Deutscher, J, Müller, D M., Kiess, W, and Richter, T
- Published
- 2003
36. Neurological Disease-Associated Autoantibodies against an Unknown Protein Encoded by a RES4-22 Homologous Gene
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Amin, M., Uhlig, H. H., Kamprad, M., Karbe, J., Osman, A. A., Grahmann, F., Hummelsheim, H., and Mothes, T.
- Published
- 2001
37. B cell epitopes of gliadin
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OSMAN, A A, GÜNNEL, T, DIETL, A, UHLIG, H H, AMIN, M, FLECKENSTEIN, B, RICHTER, T, and MOTHES, T
- Published
- 2000
38. Vedolizumab in Pediatric inflammatory bowel diseases: a retrospective multi-center experience from the paediatric IBD Porto group of ESPGHAN
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Ledder, O, de Meij, T, Martín-de-Carpi J, Richmond, L, Cohen, S, Bronsky, J, Shaoul, R, Levine, A, Escher, J, Deridder, L, Assa, A, Ruemmele, F, Shah, N, Wolters, V, Rodrigues, A, Uhlig, H, Urlep, D, Posovsky, C, Kolho, K, and Turner, D
- Abstract
Vedolizumab (VDZ) has proven as an effective medication in adult Inflammatory Bowel Disease (IBD). There has been increased off-label use of VDZ also in children but with very limited published experience. Therefore we aimed to describe the short-term effectiveness and safety of VDZ in children with IBD in the largest pediatric cohort to date.
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- 2018
39. Bacterial handling defect in macrophages of patients with defects in glucose-6-phosphate metabolism and Crohn's disease like intestinal inflammation
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Pandey, S, Balagopal, K, Aschenbrenner, D, Capitani, M, Weidinger, C, Pires, E, McCullagh, J, Travis, S, Ziegler, J, Siegmund, B, and Uhlig, H
- Abstract
Aberrant innate bacterial handling is one of the key mechanisms underlining Crohn’s disease (CD). Recently, in several inflammatory disorders defects in immunometabolism have been described but it is not clear whether this is a primary or secondary effect. Several monogenic immunodeficiencies that affect phagocyte activity present as Mendelian disorder associated inflammatory bowel disease. One intriguing subgroup is the group of patients with Glycogen storage disease type Ib (GSD-Ib) and congenital neutropenia. These patients have defective Glucose-6-phosphate metabolism caused due to genetic mutation in Glucose-6-phosphatase b and Glucose-6 phosphate-translocase (G6PT) and a subgroup develops CD-like intestinal inflammation.
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- 2018
40. TrueColours ulcerative colitis (TCUC): Will patients with UC complete digital questionnaires in real-time?
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Walsh, A, Peters, M, Hinds, CM, Kormilitzin, A, Sexton, V, Seeva, P, Brain, AO, Keshav, S, Uhlig, H, Simmons, A, Geddes, JR, Goodwin, G, Collins, G, and Travis, S
- Abstract
TCUC is a comprehensive real-time web-based programme for UC patients. It monitors multiple parameters via electronic questionnaires: symptoms, quality of life (QoL), and outcomes (eg hospitalisation). Medications are entered and personalised treatment guidance formulated. This information, graphically displayed on a traffic light system, is available to the patient and clinical team via the TCUC website (https://ouh.truecolours.nhs.uk/ibd/en/), and is housed on a secure National Health Service server. The objectives were to assess feasibility, usability and adherence of TCUC.
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- 2018
41. Development of an index that predicts escalation of therapy at an outpatient appointment in patients with known ulcerative colitis (UC)
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Walsh, A, Seeva, P, Hinds, C, Sexton, V, Wilson, J, Brain, O, Keshav, S, Uhlig, H, Geddes, JR, Goodwin, GM, Peters, M, Collins, G, and Travis, S
- Abstract
Conventional follow-up for UC places demands on health services. Demand might be better managed by targeting appointments to those patients who need therapeutic decisions. The aim was to develop a model that would predict the likelihood of escalation of therapy at an appointment.
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- 2018
42. Can daily SCCAI measurements over a 6-month period better phenotype the pattern of disease in ulcerative colitis?
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Walsh, A., Kormilitzin, A., Hinds, C., Sexton, V., Wilson, J., Peters, M., Brain, O., Keshav, S., Uhlig, H., Geddes, J., Goodwin, G., Gary Collins, and Travis, S.
- Abstract
Access to daily disease activity measurements may allow more accurate phenotyping of the pattern of disease in UC. Clustering patients by the percentage of time spent in each disease category (remission, mild, moderate, severe) may provide a more objective classification of the pattern of disease.
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- 2018
43. New faecal calprotectin cut-off points for remission and active disease defined by UCEIS and Nancy indices in ulcerative colitis (UC)
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Walsh, A., Kormilitzin, A., Hinds, C., Sexton, V., Bond, S., Wilson, J., Brain, O., Keshav, S., Uhlig, H., Geddes, J., Goodwin, G., Peters, M., Gary Collins, and Travis, S.
- Abstract
Disease activity assessment is an essential part of clinical management in UC, most accurately evaluated by endoscopy and biopsy, since patient symptoms may not reliably reflect activity. Published cut-offs for faecal calprotectin (FCal) in UC are largely based on prediction of relapse, rather than prediction of endoscopic or histopathologic activity.
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- 2018
44. Should extraintestinal manifestations (EIMs) be part of disease activity assessment in ulcerative colitis?
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Walsh, A, Kormilitzin, A, Hinds, C, Sexton, V, Wilson, J, Brain, A, Keshav, S, Uhlig, H, Geddes, J, Goodwin, G, Collins, G, and Travis, S
- Abstract
The Simple Clinical Colitis Index (SCCAI) is a clinical index specific to ulcerative colitis (UC). The SCCAI is comprised of six descriptors: daytime bowel frequency, nocturnal bowel frequency, urgency, bleeding, general well-being and EIMs. Four out of a total of 19 points are allocated to EIMs: arthritis, uveitis, erythema nodosum (EN), pyoderma gangrenosum (PG). It is increasingly clear that the major determinant of EIMs are genetic rather than due to underlying disease activity. Physicians question whether the presence or absence of EIMs have any place in an index designed to capture disease activity.
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- 2018
45. Inflammatory Bowel Disease and immune defects: A spectrum of genetic variants and clinical Pathogenicity
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Uhlig, H and Booth, C
- Published
- 2018
46. Betriebsvorschriften
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Uhlig, H. and Uhlig, H., editor
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- 1927
- Full Text
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47. Lampen und Zubehör
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Uhlig, H. and Uhlig, H., editor
- Published
- 1927
- Full Text
- View/download PDF
48. Beschaffenheit und Berlegung der Leitungen
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Uhlig, H. and Uhlig, H., editor
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- 1927
- Full Text
- View/download PDF
49. Apparate
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Uhlig, H. and Uhlig, H., editor
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- 1927
- Full Text
- View/download PDF
50. Fahrzeuge (1)
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Uhlig, H. and Uhlig, H., editor
- Published
- 1927
- Full Text
- View/download PDF
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