1. Genetically Modified T Cells for the Treatment of Malignant Disease.
- Author
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Wieczorek, Agnieszka and Uharek, Lutz
- Abstract
SummaryThe broaden application of adoptive T-cell transfer has been constrained by the technical abilities to isolate and expand antigen-specific T cells potent to selectively kill tumor cells. With the recent progress in the design and manufacturing of cellular products, T cells used in the treatment of malignant diseases may be regarded as anticancer biopharmaceuticals. Genetical manipulation of T cells has given T cells desired specificity but also enable to tailor their activation and proliferation potential. Here, we summarize the recent developments in genetic engineering of T-cell-based biopharmaceuticals, covering criteria for their clinical application in regard to safety and efficacy. © 2014 S. Karger GmbH, Freiburg [ABSTRACT FROM AUTHOR]
- Published
- 2013
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