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572 results on '"Uh, Soo-Taek"'

4. New prognostic scoring system for mortality in idiopathic pulmonary fibrosis by modifying the gender, age, and physiology model with desaturation during the six-minute walk test

Author

Lee, Jae Ha, primary, Jang, Ji Hoon, additional, Jang, Hang-Jea, additional, Kim, Song Yee, additional, Chung, Man Pyo, additional, Yoo, Hongseok, additional, Jeong, Sung Hwan, additional, Song, Jin Woo, additional, Lee, Hong Lyeol, additional, Choi, Sun Mi, additional, Kim, Young Whan, additional, Kim, Yong Hyun, additional, Park, Sung Woo, additional, Park, Jong Sun, additional, Jegal, Yangin, additional, Lee, Jongmin, additional, Uh, Soo-Taek, additional, Kim, Tae-Hyung, additional, Kim, Yee Hyung, additional, Shin, Beomsu, additional, Lee, Hyun-kyung, additional, Yang, Sei-Hoon, additional, Lee, Hyun, additional, Kim, Sang-Heon, additional, Lee, Eun-Joo, additional, Choi, Hye Sook, additional, Kang, Hyung Koo, additional, Heo, Eun Young, additional, Lee, Won-Yeon, additional, and Park, Moo Suk, additional

Published
2023
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14. Association Analysis of Melanocortin 3 Receptor Polymorphisms with the Risk of Pulmonary Tuberculosis

Author

Park, Byung Lae, Kim, Lyoung Hyo, Namgoong, Suhg, Kim, Ji On, Kim, Jason Yongha, Chang, Hun Soo, Park, Jong Sook, Jang, An Soo, Park, Sung Woo, Kim, Do Jin, Kim, Ki Up, Kim, Yang Gee, Uh, Soo-Taek, Seo, Ki Hyun, Kim, Young Hoon, Park, Choon Sik, and Shin, Hyoung Doo

Subjects
Twins -- Research -- Health aspects, Genetic polymorphisms -- Research, Tuberculosis -- Research -- Risk factors -- Patient outcomes -- Development and progression -- Care and treatment, Health
Abstract

Purpose Melanocortin 3 Receptor (MC3R) is one of the families of seven-transmembrane G-protein-coupled receptors, and a recent study showed that MCR3 promoter polymorphism was significantly associated with the susceptibility of tuberculosis (TB) in South African population. Methods We analyzed six MC3R polymorphisms to examine the genetic effects on the risk of pulmonary TB in Korean subjects by using TaqMan assays and case-control analyses. Results Using statistical analyses, one common promoter polymorphism (MC3Rrs11575886 T > C) was found to be associated with an increased risk of pulmonary TB. The frequency of the C-bearing genotype of rs11575886 was higher in pulmonary TB patients than in normal controls (p = 0.03, OR = 1.46) although the significance was not retained after correction. In silico analysis for the difference of transcription binding factor (TF), motif between C and T allele demonstrated that the TF motif and its threshold scores of C allele were lower than those of T allele. Conclusions The C allele of rs11575886 could be a risk allele for the pulmonary TB by affecting the binding of TF. Our findings suggest that polymorphisms in MC3R might be one of genetic factors for the risk of pulmonary TB development in Korean subjects. Electronic supplementary material The online version of this article (doi:10.1007/s00408-014-9625-2) contains supplementary material, which is available to authorized users., Author(s): Byung Lae Park[sup.1] , Lyoung Hyo Kim[sup.1] [sup.2] , Suhg Namgoong[sup.1] [sup.2] , Ji On Kim[sup.1] [sup.2] , Jason Yongha Kim[sup.2] , Hun Soo Chang[sup.3] [sup.4] [sup.5] , Jong [...]

Published
2014
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15. ADAM33 Gene Polymorphisms are Associated with the Risk of Idiopathic Pulmonary Fibrosis

Author

Uh, Soo-Taek, Jang, An-Soo, Park, Sung-Woo, Park, Jong-Sook, Min, Chang-Gi, Kim, Yong Hoon, Park, Byung-Lae, Shin, Hyoung Doo, Kim, Dong Soon, and Park, Choon-Sik

Subjects
Pulmonary fibrosis -- Research -- Care and treatment -- Genetic aspects -- Development and progression, Genetic polymorphisms -- Research, Health
Abstract

Background Idiopathic pulmonary fibrosis (IPF) is characterized by progressive dyspnea and worsening lung function due to remodeling of the lung, including epithelial mesenchymal transition. ADAM33 is a disintegrin and metalloprotease domain-containing protein, which may be related to lung fibrosis by exerting angiogenesis and remodeling of the lung. Thus, we evaluated the association of single-nucleotide polymorphisms (SNPs) of ADAM33 with the risk of IPF. Methods A total of 237 patients with IPF and 183 healthy subjects participated in the present study. Nine polymorphisms were selected. Genotyping was performed by single-base extension. Polymorphisms and haplotypes were analyzed for associations with the risk of IPF using multiple logistic regression models controlling for age, gender, and smoking status as covariates. Results All SNPs were in Hardy-Weinberg equilibrium. The minor allele frequency (MAF) of rs628977G>A in intron 21 was significantly lower in subjects with surgical IPF than in normal controls in the recessive model [33.2 vs. 38.0 %, p = 0.02, OR = 0.40 (0.19-0.84)]. When the subjects with clinical IPF were included, the difference in MAF persisted with a p value of 0.03 [OR = 0.50 (0.27-0.94)]. Conclusions ADAM33 rs628977G>A was marginally associated with a decreased risk of IPF in a recessive model., Author(s): Soo-Taek Uh[sup.1] , An-Soo Jang[sup.2] , Sung-Woo Park[sup.2] , Jong-Sook Park[sup.2] , Chang-Gi Min[sup.2] , Yong Hoon Kim[sup.3] , Byung-Lae Park[sup.4] , Hyoung Doo Shin[sup.4] [sup.5] , Dong Soon [...]

Published
2014
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20. Association of IL-17RB Gene Polymorphism With Asthma

Author

Jung, Ji-Sun, Park, Byung Lae, Cheong, Hyun Sub, Bae, Joon Seol, Kim, Ji-Hye, Chang, Hun Soo, Rhim, TaiYoun, Park, Jong-Sook, Jang, An-Soo, Lee, Young-Mok, Kim, Ki-Up, Uh, Soo-Taek, Na, Ju Ock, Kim, Yong-Hoon, Park, Choon-Sik, and Shin, Hyoung Doo

Published
2009
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21. Angiotensin-converting enzyme (ACE) gene polymorphisms are associated with idiopathic pulmonary fibrosis

Author

Uh, Soo-Taek, Kim, Tae-Hoon, Shim, Eun-Young, Jang, An-Soo, Park, Sung-Woo, Park, Jong-Sook, Park, Byung-Lae, Choi, Byoung Whui, Shin, Hyoung Doo, Kim, Dong Soon, and Park, Choon-Sik

Subjects
Angiotensin converting enzyme -- Physiological aspects, Pulmonary fibrosis -- Diagnosis -- Genetic aspects -- Research -- Care and treatment, Genetic polymorphisms -- Research, Genotype -- Research, Health
Abstract

Background Idiopathic pulmonary fibrosis (IPF) is characterized by progressive dyspnea and worsening lung function. ACE is increased in the bronchoalveolar lavage fluid from patients with IPF, suggesting the role of ACE in the pathogenesis of IPF. We evaluated the role of single-nucleotide polymorphisms (SNPs) in the development risk of IPF. Methods Two-hundred twenty patients with IPF and 456 healthy subjects were included in this study. Eleven polymorphisms were selected among those reported previously. Genotype was performed by single base extension. Results Although absolute LD ([absolute value of D'] = 1 and r = 1) was not present, 11 SNPs showed tight LDs. The logistic analysis of the all of 11 SNPs on the ACE genes between patients with IPF and healthy subjects were found to be related with the risk of IPF in recessive type. However, in patients with IPF diagnosed by surgical lung biopsy, only two SNP of -5538T>C and +21288_insdel SNPs were related with the risk of IPF in co-dominant type, and there were no SNPs related with the risk of IPF in dominant type. In patients with IPF diagnosed by clinical criteria or surgical lung biopsy, four SNPs on promoter (-5538T>C, -5508A>C, -3927T>C, -115T>C), one on intron (+15276A>G), one on exon (+21181G>A), and one in three prime region (+21288_insdel) were related with the risk of IPF. Conclusions This study showed a newly discovered SNP of ACE associated with the risk of development of IPF. ACE -5538T>C and -5508A>C significantly associated with risk of IPF in Korea. Keywords Angiotensin-converting enzyme * Genetic polymorphism * Genotype * Pulmonary fibrosis * SNPs, Introduction Idiopathic pulmonary fibrosis (IPF) is a devastating disease belonging to the idiopathic interstitial pneumonia family. It is characterized by progressive dyspnea and worsening lung function [1]. Although the pathogenesis [...]

Published
2013
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22. Identification of subtypes of refractory asthma in Korean patients by cluster analysis

Author

Jang, An Soo, Kwon, Hyouk-Soo, Cho, You Sook, Bae, Yun Jeong, Kim, Tae Bum, Park, Jong Sook, Park, Sung Woo, Uh, Soo- Taek, Choi, Jae-Sung, Kim, Yong-Hoon, Hwang, Hyeon-Kyu, Moon, Hee-Bom, and Park, Choon Sik

Subjects
Smoking -- Health aspects, Asthma -- Diagnosis -- Care and treatment -- Research, Health
Abstract

Background Refractory asthma, a subtype of asthma with uncontrolled symptoms despite antiasthma medications, is a heterogeneous syndrome with variable clinical features, presumably different etiologies, and pathophysiological mechanisms. The heterogeneity of refractory asthma, however, is poorly understood. We aimed to characterize refractory asthma and to improve our understanding of the heterogeneity of refractory asthma patients. Methods We identified refractory asthma patients (n = 96) as defined by the American Thoracic Society's criteria from a cohort of Korean asthma patients (n = 2,187). Then, cluster analysis was conducted to classify subtypes of refractory asthma. Results Among the study group, 4.4% (n = 96) of all asthma patients had refractory asthma. Cluster analysis identified four distinct groups of refractory asthma. Age at onset was younger in clusters 1 and 2 than in clusters 3 and 4. Patients in cluster 1 had the most well-preserved pulmonary function; patients in cluster 2 had a female predominance and the most severe airway obstruction; patients in cluster 3 were mostly female and had the most enhanced bronchial hyperresponsiveness; and patients in cluster 4 were most male and tended to be cigarette smokers. Conclusions The current results suggest that refractory asthma is a heterogeneous syndrome and could be classified into four subtypes. Underlying pathogenesis and therapeutic approaches may differ for the different subtypes and further research is needed. Keywords Asthma * Cluster analysis * Airway obstruction * Bronchial hyperreactivity, Introduction More than 90% of asthma patients can successfully manage their asthma with an inhaled corticosteroid (ICS). Despite the success of this therapy, patients with refractory asthma continue to suffer [...]

Published
2013
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33. Longitudinal Changes in Clinical Features, Management, and Outcomes of Idiopathic Pulmonary Fibrosis. A Nationwide Cohort Study

Author

Moon, Sung Woo, primary, Kim, Song Yee, additional, Chung, Man Pyo, additional, Yoo, Hongseok, additional, Jeong, Sung Hwan, additional, Kim, Dong Soon, additional, Song, Jin Woo, additional, Lee, Hong Lyeol, additional, Choi, Sun Mi, additional, Kim, Young Whan, additional, Kim, Yong Hyun, additional, Park, Choon-Sik, additional, Park, Sung-Woo, additional, Park, Jong Sun, additional, Jegal, Yangjin, additional, Lee, Jongmin, additional, Uh, Soo-Taek, additional, Kim, Tae-Hyung, additional, Lee, Jae Ha, additional, Kim, Yee Hyung, additional, Shin, Bumsu, additional, Lee, Hyun-kyung, additional, Yang, Sei-Hoon, additional, Lee, Hyun, additional, Kim, Sang-Heon, additional, Lee, Eun-Joo, additional, Choi, Hye Sook, additional, Shin, Hyejung, additional, Park, Yong Bum, additional, Shin, Jong Wook, additional, and Park, Moo Suk, additional

Published
2021
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47. CXCR3 polymorphisms associated with risk of asthma

Author

Cheong, Hyun Sub, Park, Choon-Sik, Kim, Lyoung Hyo, Park, Byung Lae, Uh, Soo-Taek, Kim, Yong Hooun, Lym, Gune-Il, Lee, Jong-Young, Lee, Jong-Keuk, Kim, Hung Tae, Ryu, Ha-Jung, Han, Bok Ghee, Kim, Jun Woo, Park, Chan, Kimm, Kuchan, Shin, Hyoung Doo, and Oh, Bermseok

Published
2005
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