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2. ESICM LIVES 2016: part three: Milan, Italy. 1–5 October 2016
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Velasquez, T., Mackey, G., Lusk, J., Kyle, U. G., Fontenot, T., Marshall, P., Shekerdemian, L. S., Coss-Bu, J. A., Nishigaki, A., Yatabe, T., Tamura, T., Yamashita, K., Yokoyama, M., Ruiz-Rodriguez, J. C., Encina, B., Belmonte, R., Troncoso, I., Tormos, P., Riveiro, M., Baena, J., Sanchez, A., Bañeras, J., Cordón, J., Duran, N., Ruiz, A., Caballero, J., Nuvials, X., Riera, J., Serra, J., Rutten, A. M. F., van Ieperen, S. N. M., Der Kinderen, E. P. H. M., Van Logten, T., Kovacikova, L., Skrak, P., Zahorec, M., Kyle, U. G., Akcan-Arikan, A., Silva, J. C., Mackey, G., Lusk, J., Goldsworthy, M., Shekerdemian, L. S., Coss-Bu, J. A., Wood, D., Harrison, D., Parslow, R., Davis, P., Pappachan, J., Goodwin, S., Ramnarayan, P., Chernyshuk, S., Yemets, H., Zhovnir, V., Pulitano’, S. M., De Rosa, S., Mancino, A., Villa, G., Tosi, F., Franchi, P., Conti, G., Patel, B., Khine, H., Shah, A., Sung, D., Singer, L., Haghbin, S., Inaloo, S., Serati, Z., Idei, M., Nomura, T., Yamamoto, N., Sakai, Y., Yoshida, T., Matsuda, Y., Yamaguchi, Y., Takaki, S., Yamaguchi, O., Goto, T., Longani, N., Medar, S., Abdel-Aal, I. R., El Adawy, A. S., Mohammed, H. M. E. H., Mohamed, A. N., Parry, S. M., Knight, L. D., Denehy, L., De Morton, N., Baldwin, C. E., Sani, D., Kayambu, G., da Silva, V. Z. M., Phongpagdi, P., Puthucheary, Z. A., Granger, C. L., Rydingsward, J. E., Horkan, C. M., Christopher, K. B., McWilliams, D., Jones, C., Reeves, E., Atkins, G., Snelson, C., Aitken, L. M., Rattray, J., Kenardy, J., Hull, A. M., Ullman, A., Le Brocque, R., Mitchell, M., Davis, C., Macfarlane, B., Azevedo, J. C., Rocha, L. L., De Freitas, F. F. M., Cavalheiro, A. M., Lucinio, N. M., Lobato, M. S., Ebeling, G., Kraegpoeth, A., Laerkner, E., De Brito-Ashurst, I., White, C., Gregory, S., Forni, L. G., Flowers, E., Curtis, A., Wood, C. A., Siu, K., Venkatesan, K., Muhammad, J. B. H., Ng, L., Seet, E., Baptista, N., Escoval, A., Tomas, E., Agrawal, R., Mathew, R., Varma, A., Dima, E., Charitidou, E., Perivolioti, E., Pratikaki, M., Vrettou, C., Giannopoulos, A., Zakynthinos, S., Routsi, C., Atchade, E., Houzé, S., Jean-Baptiste, S., Thabut, G., Genève, C., Tanaka, S., Lortat-Jacob, B., Augustin, P., Desmard, M., Montravers, P., de Molina, F. J. González, Barbadillo, S., Alejandro, R., Álvarez-Lerma, F., Vallés, J., Catalán, R. M., Palencia, E., Jareño, A., Granada, R. M., Ignacio, M. L., Cui, N., Liu, D., Wang, H., Su, L., Qiu, H., Li, R., Jaffal, K., Rouzé, A., Poissy, J., Sendid, B., Nseir, S., Paramythiotou, E., Rizos, M., Frantzeskaki, F., Antoniadou, A., Vourli, S., Zerva, L., Armaganidis, A., Riera, J., Gottlieb, J., Greer, M., Wiesner, O., Martínez, M., Acuña, M., Rello, J., Welte, T., Atchade, E., Mignot, T., Houzé, S., Jean-Baptiste, S., Thabut, G., Lortat-Jacob, B., Tanaka, S., Augustin, P., Desmard, M., Montravers, P., Soussi, S., Dudoignon, E., Ferry, A., Chaussard, M., Benyamina, M., Alanio, A., Touratier, S., Chaouat, M., Lafaurie, M., Mimoun, M., Mebazaa, A., Legrand, M., Sheils, M. A., Patel, C., Mohankumar, L., Akhtar, N., Noriega, S. K. Pacheco, Aldana, N. Navarrete, León, J. L. Ávila, Baquero, J. Durand, Bernal, F. Fernández, Ahmadnia, E., Hadley, J. S., Millar, M., Hall, D., Hewitt, H., Yasuda, H., Sanui, M., Komuro, T., Kawano, S., Andoh, K., Yamamoto, H., Noda, E., Hatakeyama, J., Saitou, N., Okamoto, H., Kobayashi, A., Takei, T., Matsukubo, S., Rotzel, H. B., Lázaro, A. Serrano, Prada, D. Aguillón, Gimillo, M. Rodriguez, Barinas, O. Diaz, Cortes, M. L. Blasco, Franco, J. Ferreres, Roca, J. M. Segura, Carratalá, A., Gonçalves, B., Turon, R., Mendes, A., Miranda, F., Mata, P. J., Cavalcanti, D., Melo, N., Lacerda, P., Kurtz, P., Righy, C., Rosario, L. E. de la Cruz, Lesmes, S. P. Gómez, Romero, J. C. García, Herrera, A. N. García, Pertuz, E. D. Díaz, Sánchez, M. J. Gómez, Sanz, E. Regidor, Hualde, J. Barado, Hernández, A. Ansotegui, Irazabal, J. M. Guergué, Spatenkova, V., Bradac, O., Suchomel, P., Urli, T., Lazzeri, E. Heusch, Aspide, R., Zanello, M., Perez-Borrero, L., Garcia-Alvarez, J. M., Arias-Verdu, M. D., Aguilar-Alonso, E., Rivera-Fernandez, R., Mora-Ordoñez, J., De La Fuente-Martos, C., Castillo-Lorente, E., Guerrero-Lopez, F., Lesmes, S. P. Gómez, Rosario, L. E. De la Cruz, Pertuz, E. D. Díaz, Hernández, A. Ansotegui, Romero, J. C. García, Sánchez, M. J. Gómez, Herrera, A. N. García, Ramírez, J. Roldán, Sanz, E. Regidor, Hualde, J. Barado, León, J. P. Tirapu, Navarro-Guillamón, L., Cordovilla-Guardia, S., Iglesias-Santiago, A., Guerrero-López, F., Fernández-Mondéjar, E., Vidal, A., Perez, M., Juez, A., Arias, N., Colino, L., Perez, J. L., Pérez, H., Calpe, P., Alcala, M. A., Robaglia, D., Perez, C., Lan, S. K., Cunha, M. M., Moreira, T., Santos, F., Lafuente, E., Fernandes, M. J., Silva, J. G., Rosario, L. E. de la Cruz, Lesmes, S. P. Gómez, Herrera, A. N. García, Romero, J. C. García, Pertuz, E. D. Díaz, Sánchez, M. J. Gómez, Sanz, E. Regidor, Echeverría, J. G. Armando, Hernández, A. Ansotegui, Hualde, J. Barado, Podlepich, V., Sokolova, E., Alexandrova, E., Lapteva, K., Kurtz, P., Shuinotsuka, C., Rabello, L., Vianna, G., Reis, A., Cairus, C., Salluh, J., Bozza, F., Torres, J. C. Barrios, Araujo, N. J. Fernández, García-Olivares, P., Keough, E., Dalorzo, M., Tang, L. K., De Sousa, I., Díaz, M., Marcos-Zambrano, L. J., Guerrero, J. E., Gomez, S. E. Zamora, Lopez, G. D. Hernandez, Cuellar, A. I. Vazquez, Nieto, O. R. Perez, Gonzalez, J. A. Castanon, Bhasin, D., Rai, S., Singh, H., Gupta, O., Bhattal, M. K., Sampley, S., Sekhri, K., Nandha, R., Aliaga, F. A., Olivares, F., Appiani, F., Farias, P., Alberto, F., Hernández, A., Pons, S., Sonneville, R., Bouadma, L., Neuville, M., Mariotte, E., Radjou, A., Lebut, J., Chemam, S., Voiriot, G., Dilly, M. P., Mourvillier, B., Dorent, R., Nataf, P., Wolff, M., Timsit, J. F., Ediboglu, O., Ataman, S., Ozkarakas, H., Kirakli, C., Vakalos, A., Avramidis, V., Obukhova, O., Kurmukov, I. A., Kashiya, S., Golovnya, E., Baikova, V. N., Ageeva, T., Haritydi, T., Kulaga, E. V., Rios-Toro, J. J., Perez-Borrero, L., Aguilar-Alonso, E., Arias-Verdu, M. D., Garcia-Alvarez, J. M., Lopez-Caler, C., De La Fuente-Martos, C., Rodriguez-Fernandez, S., Sanchez-Orézzoli, M. Gomez, Martin-Gallardo, F., Nikhilesh, J., Joshi, V., Villarreal, E., Ruiz, J., Gordon, M., Quinza, A., Gimenez, J., Piñol, M., Castellanos, A., Ramirez, P., Jeon, Y. D., Jeong, W. Y., Kim, M. H., Jeong, I. Y., Ahn, M. Y., Ahn, J. Y., Han, S. H., Choi, J. Y., Song, Y. G., Kim, J. M., Ku, N. S., Shah, H., Kellner, F., Rezai, F., Mistry, N., Yodice, P., Ovnanian, V., Fless, K., Handler, E., Alejos, R. Martínez, Romeu, J. D. Martí, Antón, D. González, Quinart, A., Martí, A. Torres, Llaurado-Serra, M., Lobo-Civico, A., Ventura-Rosado, A., Piñol-Tena, A., Pi-Guerrero, M., Paños-Espinosa, C., Peralvo-Bernat, M., Marine-Vidal, J., Gonzalez-Engroba, R., Montesinos-Cerro, N., Treso-Geira, M., Valeiras-Valero, A., Martinez-Reyes, L., Sandiumenge, A., Jimenez-Herrera, M. F., Helyar, S., Riozzi, P., Noon, A., Hallows, G., Cotton, H., Keep, J., Hopkins, P. A., Taggu, A., Renuka, S., Sampath, S., Rood, P. J. T., Frenzel, T., Verhage, R., Bonn, M., Pickkers, P., van der Hoeven, J. G., van den Boogaard, M., Corradi, F., Melnyk, L., Moggia, F., Pienovi, R., Adriano, G., Brusasco, C., Mariotti, L., Lattuada, M., Bloomer, M. J., Coombs, M., Ranse, K., Endacott, R., Maertens, B., Blot, K., Blot, S., Amerongen, M. P. van Nieuw, van der Heiden, E. S., Twisk, J. W. R., Girbes, A. R. J., Spijkstra, J. J., Riozzi, P., Helyar, S., Cotton, H., Hallows, G., Noon, A., Bell, C., Peters, K., Feehan, A., Keep, J., Hopkins, P. A., Churchill, K., Hawkins, K., Brook, R., Paver, N., Endacott, R., Maistry, N., van Wijk, A., Rouw, N., van Galen, T., Evelein-Brugman, S., Taggu, A., Krishna, B., Sampath, S., Putzu, A., Fang, M., Berto, M. Boscolo, Belletti, A., Cassina, T., Cabrini, L., Mistry, M., Alhamdi, Y., Welters, I., Abrams, S. T., Toh, C. H., Han, H. S., Gil, E. M., Lee, D. S., Park, C. M., Winder-Rhodes, S., Lotay, R., Doyle, J., Ke, M. W., Huang, W. C., Chiang, C. H., Hung, W. T., Cheng, C. C., Lin, K. C., Lin, S. C., Chiou, K. R., Wann, S. R., Shu, C. W., Kang, P. L., Mar, G. Y., Liu, C. P., Dubó, S., Aquevedo, A., Jibaja, M., Berrutti, D., Labra, C., Lagos, R., García, M. F., Ramirez, V., Tobar, M., Picoita, F., Peláez, C., Carpio, D., Alegría, L., Hidalgo, C., Godoy, K., Bakker, J., Hernández, G., Sadamoto, Y., Katabami, K., Wada, T., Ono, Y., Maekawa, K., Hayakawa, M., Sawamura, A., Gando, S., Marin-Mateos, H., Perez-Vela, J. L., Garcia-Gigorro, R., Peiretti, M. A. Corres, Lopez-Gude, M. J., Chacon-Alves, S., Renes-Carreño, E., Montejo-González, J. C., Parlevliet, K. L., Touw, H. R. W., Beerepoot, M., Boer, C., Elbers, P. W. G., Tuinman, P. R., Abdelmonem, S. A., Helmy, T. A., El Sayed, I., Ghazal, S., Akhlagh, S. H., Masjedi, M., Hozhabri, K., Kamali, E., Zýková, I., Paldusová, B., Sedlák, P., Morman, D., Youn, A. M., Ohta, Y., Sakuma, M., Bates, D., Morimoto, T., Su, P. L., Chang, W. Y., Lin, W. C., Chen, C. W., Facchin, F., Zarantonello, F., Panciera, G., De Cassai, A., Venrdramin, A., Ballin, A., Tonetti, T., Persona, P., Ori, C., Del Sorbo, L., Rossi, S., Vergani, G., Cressoni, M., Chiumello, D., Chiurazzi, C., Brioni, M., Algieri, I., Tonetti, T., Guanziroli, M., Colombo, A., Tomic, I., Colombo, A., Crimella, F., Carlesso, E., Gasparovic, V., Gattinoni, L., Neto, A. Serpa, Schmidt, M., Pham, T., Combes, A., de Abreu, M. Gama, Pelosi, P., Schultz, M. J., Katira, B. H., Engelberts, D., Giesinger, R. E., Ackerley, C., Yoshida, T., Zabini, D., Otulakowski, G., Post, M., Kuebler, W. M., McNamara, P. J., Kavanagh, B. P., Pirracchio, R., Rigon, M. Resche, Carone, M., Chevret, S., Annane, D., Eladawy, S., El-Hamamsy, M., Bazan, N., Elgendy, M., De Pascale, G., Vallecoccia, M. S., Cutuli, S. L., Di Gravio, V., Pennisi, M. A., Conti, G., Antonelli, M., Andreis, D. T., Khaliq, W., Singer, M., Hartmann, J., Harm, S., Carmona, S. Alcantara, Almudevar, P. Matia, Abellán, A. Naharro, Ramos, J. Veganzones, Pérez, L. Pérez, Valbuena, B. Lobo, Sanz, N. Martínez, Simón, I. Fernández, Arrigo, M., Feliot, E., Deye, N., Cariou, A., Guidet, B., Jaber, S., Leone, M., Resche-Rigon, M., Baron, A. Vieillard, Legrand, M., Gayat, E., Mebazaa, A., Balik, M., Kolnikova, I., Maly, M., Waldauf, P., Tavazzi, G., Kristof, J., Herpain, A., Su, F., Post, E., Taccone, F., Vincent, J. L., Creteur, J., Lee, C., Hatib, F., Jian, Z., Buddi, S., Cannesson, M., Fileković, S., Turel, M., Knafelj, R., Gorjup, V., Stanić, R., Gradišek, P., Cerović, O., Mirković, T., Noč, M., Tirkkonen, J., Hellevuo, H., Olkkola, K. T., Hoppu, S., Lin, K. C., Hung, W. T., Chiang, C. C., Huang, W. C., Juan, W. C., Lin, S. C., Cheng, C. C., Lin, P. H., Fong, K. Y., Hou, D. S., Kang, P. L., Wann, S. R., Chen, Y. S., Mar, G. Y., Liu, C. P., Paul, M., Bougouin, W., Geri, G., Dumas, F., Champigneulle, B., Legriel, S., Charpentier, J., Mira, J. P., Sandroni, C., Cariou, A., Zimmerman, J., Sullivan, E., Noursadeghi, M., Fox, B., Sampson, D., McHugh, L., Yager, T., Cermelli, S., Seldon, T., Bhide, S., Brandon, R. A., Brandon, R. B., Zwaag, J., Beunders, R., Pickkers, P., Kox, M., Gul, F., Arslantas, M. K., Genc, D., Zibandah, N., Topcu, L., Akkoc, T., Cinel, I., Greco, E., Lauretta, M. P., Andreis, D. T., Singer, M., Garcia, I. Palacios, Cordero, M., Martin, A. Diaz, Pallás, T. Aldabó, Montero, J. Garnacho, Rey, J. Revuelto, Malo, L. Roman, Montoya, A. A. Tanaka, Martinez, A. D. C. Amador, Ayala, L. Y. Delgado, Zepeda, E. Monares, Granillo, J. Franco, Sanchez, J. Aguirre, Alejo, G. Camarena, Cabrera, A. Rugerio, Montenegro, A. Pedraza, Pham, T., Beduneau, G., Schortgen, F., Piquilloud, L., Zogheib, E., Jonas, M., Grelon, F., Runge, I., Terzi, N., Grangé, S., Barberet, G., Guitard, P. G., Frat, J. P., Constan, A., Chrétien, J. M., Mancebo, J., Mercat, A., Richard, J. C. M., Brochard, L., Soilemezi, E., Koco, E., Savvidou, S., Nouris, C., Matamis, D., Di Mussi, R., Spadaro, S., Volta, C. A., Mariani, M., Colaprico, A., Antonio, C., Bruno, F., Grasso, S., Rodriguez, A., Martín-Loeches, I., Díaz, E., Masclans, J. R., Gordo, F., Solé-Violán, J., Bodí, M., Avilés-Jurado, F. X., Trefler, S., Magret, M., Reyes, L. F., Marín-Corral, J., Yebenes, J. C., Esteban, A., Anzueto, A., Aliberti, S., Restrepo, M. I., Larsson, J. Skytte, Redfors, B., Ricksten, S. E., Haines, R., Powell-Tuck, J., Leonard, H., Ostermann, M., Berthelsen, R. E., Itenov, T. S., Perner, A., Jensen, J. U., Ibsen, M., Jensen, A. E. K., Bestle, M. H., Bucknall, T., Dixon, J., Boa, F., MacPhee, I., Philips, B. J., Doyle, J., Saadat, F., Samuels, T., Huddart, S., McCormick, B., DeBrunnar, R., Preece, J., Swart, M., Peden, C., Richardson, S., Forni, L., Kalfon, P., Baumstarck, K., Estagnasie, P., Geantot, M. A., Berric, A., Simon, G., Floccard, B., Signouret, T., Boucekine, M., Fromentin, M., Nyunga, M., Sossou, A., Venot, M., Robert, R., Follin, A., Renault, A., Garrouste, M., Collange, O., Levrat, Q., Villard, I., Thévenin, D., Pottecher, J., Patrigeon, R. G., Revel, N., Vigne, C., Mimoz, O., Auquier, P., Pawar, S., Jacques, T., Deshpande, K., Pusapati, R., Wood, B., Pulham, R. A., Wray, J., Brown, K., Pierce, C., Nadel, S., Ramnarayan, P., Azevedo, J. R., Montenegro, W. S., Rodrigues, D. P., Sousa, S. C., Araujo, V. F., Leitao, A. L., Prazeres, P. H., Mendonca, A. V., Paula, M. P., Das Neves, A., Loudet, C. I., Busico, M., Vazquez, D., Villalba, D., Lischinsky, A., Veronesi, M., Emmerich, M., Descotte, E., Juliarena, A., Bisso, M. Carboni, Grando, M., Tapia, A., Camargo, M., Ulla, D. Villani, Corzo, L., dos Santos, H. Placido, Ramos, A., Doglia, J. A., Estenssoro, E., Carbonara, M., Magnoni, S., Donald, C. L. Mac, Shimony, J. S., Conte, V., Triulzi, F., Stretti, F., Macrì, M., Snyder, A. Z., Stocchetti, N., Brody, D. L., Podlepich, V., Shimanskiy, V., Savin, I., Lapteva, K., Chumaev, A., Tjepkema-Cloostermans, M. C., Hofmeijer, J., Beishuizen, A., Hom, H., Blans, M. J., van Putten, M. J. A. M., Longhi, L., Frigeni, B., Curinga, M., Mingone, D., Beretta, S., Patruno, A., Gandini, L., Vargiolu, A., Ferri, F., Ceriani, R., Rottoli, M. R., Lorini, L., Citerio, G., Pifferi, S., Battistini, M., Cordolcini, V., Agarossi, A., Di Rosso, R., Ortolano, F., Stocchetti, N., Lourido, C. Mora, Cabrera, J. L. Santana, Santana, J. D. Martín, Alzola, L. Melián, del Rosario, C. García, Pérez, H. Rodríguez, Torrent, R. Lorenzo, Eslami, S., Dalhuisen, A., Fiks, T., Schultz, M. J., Hanna, A. Abu, Spronk, P. E., Wood, M., Maslove, D., Muscedere, J., Scott, S. H., Saha, T., Hamilton, A., Petsikas, D., Payne, D., Boyd, J. G., Puthucheary, Z. A., McNelly, A. S., Rawal, J., Connolly, B., McPhail, M. J., Sidhu, P., Rowlerson, A., Moxham, J., Harridge, S. D., Hart, N., Montgomery, H. E., Jovaisa, T., Thomas, B., Gupta, D., Wijayatilake, D. S., Shum, H. P., King, H. S., Chan, K. C., Tang, K. B., Yan, W. W., Arias, C. Castro, Latorre, J., De La Rica, A. Suárez, Garrido, E. Maseda, Feijoo, A. Montero, Gancedo, C. Hernández, Tofiño, A. López, Rodríguez, F. Gilsanz, Gemmell, L. K., Campbell, R., Doherty, P., MacKay, A., Singh, N., Vitaller, S., Nagib, H., Prieto, J., Del Arco, A., Zayas, B., Gomez, C., Tirumala, S., Pasha, S. A., Kumari, B. K., Martinez-Lopez, P., Puerto-Morlán, A., Nuevo-Ortega, P., Pujol, L. Martinez, Dolset, R. Algarte, González, B. Sánchez, Riera, S. Quintana, Álvarez, J. Trenado, Quintana, S., Martínez, L., Algarte, R., Sánchez, B., Trenado, J., Tomas, E., Brock, N., Viegas, E., Filipe, E., Cottle, D., Traynor, T., Martínez, M. V. Trasmonte, Márquez, M. Pérez, Gómez, L. Colino, Martínez, N. Arias, Muñoz, J. M. Milicua, Bellver, B. Quesada, Varea, M. Muñoz, Llorente, M. Á. Alcalá, Calvo, C. Pérez, Hillier, S. D., Faulds, M. C., Hendra, H., Lawrence, N., Maekawa, K., Hayakawa, M., Ono, Y., Kodate, A., Sadamoto, Y., Tominaga, N., Mizugaki, A., Murakami, H., Yoshida, T., Katabami, K., Wada, T., Sawamura, A., Gando, S., Silva, S., Kerhuel, L., Malagurski, B., Citerio, G., Chabanne, R., Laureys, S., Puybasset, L., Nobile, L., Pognuz, E. R., Rossetti, A. O., Verginella, F., Gaspard, N., Creteur, J., Ben-Hamouda, N., Oddo, M., Taccone, F. S., Ono, Y., Hayakawa, M., Iijima, H., Maekawa, K., Kodate, A., Sadamoto, Y., Mizugaki, A., Murakami, H., Katabami, K., Wada, T., Sawamura, A., Gando, S., Kodate, A., Katabami, K., Wada, T., Ono, Y., Maekawa, K., Hayakawa, M., Sawamura, A., Gando, S., Andersen, L. W., Raymond, T., Berg, R., Nadkarni, V., Grossestreuer, A., Kurth, T., Donnino, M., Krüger, A., Ostadal, P., Janotka, M., Vondrakova, D., Kongpolprom, N., Cholkraisuwat, J., Pekkarinen, P. T., Ristagno, G., Masson, S., Latini, R., Bendel, S., Ala-Kokko, T., Varpula, T., Vaahersalo, J., Hoppu, S., Tiainen, M., Mion, M. M., Plebani, M., Pettilä, V., Skrifvars, M.B., Son, Y., Kim, K. S., Suh, G. J., Kwon, W. Y., Ko, J. I., Park, M. J., Cavicchi, F. Zama, Iesu, E., Nobile, L., Vincent, J. L., Creteur, J., Taccone, F. S., Tanaka, H., Otani, N., Ode, S., Ishimatsu, S., Martínez, L., Algarte, R., Sánchez, B., Romero, I., Martínez, F., Quintana, S., Trenado, J., Vondrakova, D., Ostadal, P., Kruger, A., Janotka, M., Malek, F., Neuzil, P., Yeh, Y. C., Chen, Y. S., Wang, C. H., Huang, C. H., Chao, A., Lee, C. T., Lai, C. H., Chan, W. S., Cheng, Y. J., Sun, W. Z., Kaese, S., Horstmann, C., Lebiedz, P., Mourad, M., Gaudard, P., Eliet, J., Zeroual, N., Colson, P., Ostadal, P., Mlcek, M., Hrachovina, M., Kruger, A., Vondrakova, D., Janotka, M., Mates, M., Hala, P., Kittnar, O., Neuzil, P., Jacky, A., Rudiger, A., Spahn, D. R., Bettex, D. A., Kara, A., Akin, S., Dos reis Miranda, D., Struijs, A., Caliskan, K., van Thiel, R. J., Dubois, E. A., de Wilde, W., Zijlstra, F., Gommers, D., Ince, C., Marca, L., Xini, A., Mongkolpun, W., Cordeiro, C. P. R., Leite, R. T., Lheureux, O., Bader, A., Rincon, L., Santacruz, C., Preiser, J. C., Chao, A., Chao, A. S., Chen, Y. S., Kim, W., Ahn, C., Cho, Y., Lim, T. 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Agudo, León, J. P. Tirapu, Irazabal, J. M. Guergue, Pérez, A. González, Fernández, P. Alvarez, Amor, L. Lopéz, Albaiceta, G. Muñiz, Lesmes, S. P. Gómez, Rosario, L. E. De la Cruz, Hernández, A. Ansotegui, Sanz, E. Regidor, Sánchez, M. J. Gómez, Calvo, S. Aldunate, Herrera, A. N. García, Hualde, J. Barado, Pascual, O. Agudo, León, J. P. Tirapu, Corona, A., Ruffini, C., Spazzadeschi, A., Marrazzo, F., Gandola, A., Sciurti, R., Savi, C., Catena, E., Ke, M. W., Cheng, C. C., Huang, W. C., Chiang, C. H., Hung, W. T., Lin, K. C., Lin, S. C., Wann, S. R., Chiou, K. R., Tseng, C. J., Kang, P. L., Mar, G. Y., Liu, C. P., Bertini, P., De Sanctis, F., Guarracino, F., Bertini, P., Baldassarri, R., Guarracino, F., Buitinck, S. H., van der Voort, P. H. J., Oto, J., Nakataki, E., Tsunano, Y., Izawa, M., Tane, N., Onodera, M., Nishimura, M., Ghosh, S., Gupta, A., De Gasperi, A., Mazza, E., Limuti, R., Prosperi, M., Bissenova, N., Yergaliyeva, A., Talan, L., Yılmaz, G., Güven, G., Yoruk, F., Altıntas, N. D., Mukherjee, D. N., Agarwal, L. K., Mandal, K., Palomar, M., Balsera, B., Vallverdu, M., Martinez, M., Garcia, M., Castellana, D., Lopez, R., Barcenilla, F., Kaminsky, G. E., Carreño, R., Escribá, A., Fuentes, M., Gálvez, V., Del Olmo, R., Nieto, B., Vaquerizo, C., Alvarez, J., De la Torre, M. A., Torres, E., Bogossian, E., Nouer, S. Aranha, Salgado, D. Ribeiro, Brugger, S. Carvalho, Jiménez, G. Jiménez, Torner, M. Miralbés, Vidal, M. Vallverdú, Garrido, B. Balsera, Casals, X. Nuvials, Gaite, F. Barcenilla, Cabello, J. Trujillano, Martínez, M. Palomar, Doganci, M., Izdes, S., Besevli, S. Guzeldag, Alkan, A., Kayaaslan, B., Ramírez, C. Sánchez, Balcázar, L. Caipe, Santana, M. Cabrera, Viera, M. A. Hernández, Escalada, S. Hípola, Vázquez, C. F. Lübbe, Penichet, S. M. Marrero, Campelo, F. Artiles, López, M. A. De La Cal, Santana, P. Saavedra, Santana, S. Ruíz, Repessé, X., Artiguenave, M., Paktoris-Papine, S., Espinasse, F., Dinh, A., El Sayed, F., Charron, C., Géri, G., Vieillard-Baron, A., Marmanidou, K., Oikonomou, M., Nouris, C., Dimitroulakis, K., Soilemezi, E., Matamis, D., Ferré, A., Guillot, M., Teboul, J. L., Lichtenstein, D., Mézière, G., Richard, C., Monnet, X., Pham, T., Beduneau, G., Schortgen, F., Piquilloud, L., Zogheib, E., Jonas, M., Grelon, F., Runge, I., Terzi, N., Grangé, S., Barberet, G., Guitard, P. G., Frat, J. P., Constan, A., Chrétien, J. M., Mancebo, J., Mercat, A., Richard, J. C. M., Brochard, L., Prīdāne, S., Sabeļņikovs, O., Mojoli, F., Orlando, A., Bianchi, I., Torriglia, F., Bianzina, S., Pozzi, M., Iotti, G. A., Braschi, A., Beduneau, G., Pham, T., Schortgen, F., Piquilloud, L., Zogheib, E., Jonas, M., Grelon, F., Runge, I., Terzi, N., Grangé, S., Barberet, G., Guitard, P. G., Frat, J. P., Constan, A., Chrétien, J. M., Mancebo, J., Mercat, A., Richard, J. C. M., Brochard, L., Kondili, E., Psarologakis, C., Kokkini, S., Amargianitakis, V., Babalis, D., Chytas, A., Chouvarda, I., Vaporidi, K., Georgopoulos, D., Trapp, O., Kalenka, A., Mojoli, F., Orlando, A., Bianchi, I., Torriglia, F., Bianzina, S., Pozzi, M., Iotti, G. A., Braschi, A., Lozano, J. A. Benítez, Sánchez, P. Carmona, Francioni, J. E. Barrueco, Ferrón, F. Ruiz, Simón, J. M. Serrano, Spadaro, S., Karbing, D. S., Gioia, A., Moro, F., Corte, F. Dalla, Mauri, T., Volta, C. A., Rees, S. E., Petrova, M. V., Mohan, R., Butrov, A. V., Beeharry, S. D., Vatsik, M. V., Sakieva, F. I., Gobert, F., Yonis, H., Tapponnier, R., Fernandez, R., Labaune, M. A., Burle, J. F., Barbier, J., Vincent, B., Cleyet, M., Richard, J. C., Guérin, C., Shinotsuka, C. Righy, Creteur, J., Taccone, F. S., Törnblom, S., Nisula, S., Vaara, S., Poukkanen, M., Andersson, S., Pettilä, V., Pesonen, E., Xie, Z., Liao, X., Kang, Y., Zhang, J., Kubota, K., Egi, M., Mizobuchi, S., Hegazy, S., El-Keraie, A., El Sayed, E., El Hamid, M. Abd, Rodrigues, N. J., Pereira, M., Godinho, I., Gameiro, J., Neves, M., Gouveia, J., e Silva, Z. Costa, Lopes, J. A., Mckinlay, J., Kostalas, M., Kooner, G., Dudas, G., Horton, A., Kerr, C., Karanjia, N., Creagh-Brown, B., Forni, L., Yamazaki, A., Ganuza, M. Sanz, Molina, J. A. Martinez, Martinez, F. Hidalgo, Freile, M. T. Chiquito, Fernandez, N. Garcia, Travieso, P. Medrano, Bandert, A., Frithiof, R., Lipcsey, M., Smekal, D., Schlaepfer, P., Durovray, J. D., Plouhinec, V., Chiappa, C., Bellomo, R., Schneider, A. G., Mitchell, S., Durrant, J., Street, H., Dunthorne, E., Shears, J., Caballero, C. Hernandez, Hutchison, R., Schwarze, S., Ghabina, S., Thompson, E., Prowle, J. R., Kirwan, C. J., Gonzalez, C. A., Pinto, J. L., Orozco, V., Patiño, J. A., Garcia, P. K., Contreras, K. M., Rodriguez, P., Echeverri, J. E., GETGAG Working Group, JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group, CAPCRI Study, for the ReVA Research Network and the PROVE Network Investigators, from the FROG ICU Investigators, The WIND study group, Plug Working Group, GETGAG/SEMICYUC, AKI Research Group, St George’s University of London, IPREA Study Group, FINNRESUSCI Study Group, PICS- HCPA: Programa Intrahospitalar de Combate à Sepse do Hospital de Clínicas de Porto Alegre, ENVIN-HELICS Study Group, ARIAM registry of adult cardiac surgery, The Rapid Diagnosis of Infections in the Critically Ill Team, Tokyo Womens Medical University, PLUG working group, PLUG Working Group, On behalf of Okayama Research Investigation Organizing Network (ORION)investigators, PS-ICU Group, Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group, Student Research Committee - Shiraz University of Medical Sciences, ARIAM-ANDALUCIA, The WIND study group, PLUG Working Group, The WIND study group, PLUG Working Group, and Plug working group
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- 2016
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3. B-type natriuretic peptide and estimated glomerular filtration rate at ICU admission as a predictor of delirium
- Author
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Hirayama, T, Ichiba, S, Sato, K, Yumoto, T, Tsukahara, K, Terado, M, Yoshihito, U, and Ugawa, T
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- 2015
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4. 38P Effects of antiemetics on zolbetuximab-induced gastric injury and emesis frequency in ferrets
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Weng, J., Kinugasa, F., Kajikawa, S., Yamanaka, Y., Ugawa, T., Fushiki, H., and Akuzawa, S.
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- 2023
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5. New simplified criteria for predicting massive transfusion in trauma
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Yumoto, T, Iida, A, Knaup, E, Nosaka, N, Morisada, S, Hirayama, T, Shiba, N, Tsukahara, K, Nosaka, H, Kinami, Y, Terado, M, Yamanouchi, H, Sato, K, Ugawa, T, Ichiba, S, and Ujike, Y
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- 2014
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6. Predicting the return of spontaneous circulation after out-of-hospital cardiac arrest through blood gas analysis
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Umei, N, Shingo, I, Ujike, Y, Yumoto, T, Ida, A, Hirayama, T, Shiba, N, Tsukahara, K, Kinami, Y, Terado, M, Yamanouchi, H, Sato, K, and Ugawa, T
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- 2015
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7. The Clinical Application of Hydrogen as a Medical Treatment
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Iida, A., Nosaka, N., Yumoto, T., Knaup, E., Hiromichi Naito, Nishiyama, C., Yamakawa, Y., Tsukahara, K., Terado, M., Sato, K., Ugawa, T., and Nkao, A.
- Subjects
Oxidative Stress ,medical gas ,Humans ,antioxidant effect ,gaseous signaling molecule ,Gases ,clinical tests ,Antioxidants ,Hydrogen ,Signal Transduction - Abstract
In recent years, it has become evident that molecular hydrogen is a particularyl effective treatment for various disease models such as ischemia-reperfusion injury; as a result, research on hydrogen has progressed rapidly. Hydrogen has been shown to be effective not only through intake as a gas, but also as a liquid medication taken orally, intravenously, or locally. Hydrogenʼs effectiveness is thus multifaceted. Herein we review the recent research on hydrogen-rich water, and we examine the possibilities for its clinical application. Now that hydrogen is in the limelight as a gaseous signaling molecule due to its potential ability to inhibit oxidative stress signaling, new research developments are highly anticipated.
- Published
- 2016
8. Improved survival with an innovative approach to the treatment of severely burned patients: development of a burn treatment manual
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Morisada, S., Nosaka, N., Tsukahara, K., Ugawa, T., Sato, K., and Ujike, Y.
- Subjects
Research Article - Abstract
The management of severely burned patients remains a major issue worldwide as indicated by the high incidence of permanent debilitating complications and poor survival rates. In April 2012, the Advanced EmergencyCritical Care Medical Center of the Okayama University Hospital began implementing guidelines for severely burned patients, distributed as a standard burn treatment manual. The protocol, developed in-house, was validated by comparing the outcomes of patients with severe extensive burns (SEB) treated before and after implementation of these new guidelines at this institution. The patients included in this study had a burn index (BI) ≥30 or a prognostic burn index (PBI = BI + patient's age) ≥100. The survival rate of the patients with BI ≥30 was 65.2% with the traditional treatment and 100% with the new guidelines. Likewise, the survival rate of the patients with PBI ≥100 was 61.1% with the traditional treatment compared to 100% with the new guidelines. Together, these data demonstrate that the new treatment guidelines dramatically improved the treatment outcome and survival of SEB patients.La prise en charge des patients gravement brûlés est toujours un problème majeur dans le monde, avec une mortalité élevée et de lourdes séquelles chez les survivants. En Avril 2012, le Centre de l’Hôpital de l’Université d’Okayama a commencé à distribuer un manuel pour le traitement des patients gravement brûlés. Notre protocole a été validé en comparant les résultats des patients souffrant de brûlures étendues traités avant et après la mise en oeuvre de ces nouvelles lignes directrices. Les patients inclus dans cette étude avaient une surface brûlée (SB) ≥30% ou un index de Baux (IBx= SB + âge du patient) ≥100. Le taux de survie chez les patients atteints sur ≥30% SB était de 65.2% avant et 100% après. Le taux de survie chez les patients avec un IBx ≥100 était de 61.1% avant et 100% après. Ces données démontrent que les nouvelles lignes directrices de traitement ont amélioré considérablement la survie chez ces patients.
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- 2015
9. Magnetic Alignment in $\hbox{REBa}_{2}\hbox{Cu}_{3-{\rm x}}\hbox{Co}_{\rm x}\hbox{O}_{\rm y}$ Compounds
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Horii, S., primary, Ugawa, T., additional, Haruta, M., additional, Ishihara, A., additional, and Shimoyama, J., additional
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- 2013
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10. Project Report: Toward the Realization of Highly Reliable Embedded Systems.
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Katayama, T., Kishi, T., Hosoai, S., Nakajima, T., Yuasa, T., Sugaya, M., and Ugawa, T.
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- 2009
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11. Replication-Based Incremental Compaction.
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Ugawa, T., Yasugi, M., and Yuasa, T.
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- 2008
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12. Doping effects of Fe ion on magnetic anisotropy of YBa2Cu3O y.
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Ugawa, T., Horii, S., Maeda, T., Haruta, M., and Shimoyama, J.
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- *
IRON ions , *MAGNETIC anisotropy , *DOPING agents (Chemistry) , *YTTRIUM barium copper oxide , *MICROSTRUCTURE , *MAGNETIC properties of metals - Abstract
Highlights: [•] We clarified orientation effects of Fe-doped Y123 in modulated rotating fields. [•] Y123 showed two different hard magnetic axes due to twin microstructures. [•] The two hard magnetic axes in Fe-doped Y123 were [100] and [110] directions. [•] Magnetic anisotropy of the [110] grain was higher than that of the [100] grain. [ABSTRACT FROM AUTHOR]
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- 2013
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13. Enhancement of canine taste responses to umami substances by salts
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Ugawa, T., primary and Kurihara, K., additional
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- 1994
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14. Large enhancement of canine taste responses to amino acids by salts
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Ugawa, T., primary and Kurihara, K., additional
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- 1993
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15. Molecular Recognition Kinetics of Leucine and Glycyl-Leucine by β-Cyclodextrin in Aqueous Solution in Terms of Ultrasonic Relaxation
- Author
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Fukahori, T., Ugawa, T., and Nishikawa, S.
- Abstract
Ultrasonic absorption coefficients in the frequency range of 0.8−95 MHz were measured in aqueous solution of leucine and glycyl-leucine in the presence and absence of β-cyclodextrin (β-CD) at 25 °C. A single relaxational absorption was found in both solutions although it was not observed in the absence of β-CD. The cause of the relaxation was attributed to a perturbation of a chemical equilibrium associated with an interaction between β-CD and the amino acid or the dipeptide. The rate and thermodynamic constants for the association and dissociation reaction of the complex in the system of glycyl-leucine and β-CD were determined from the concentration dependence of the relaxation frequency and the maximum absorption per wavelength. On the other hand, another analysis was applied for the system with leucine and β-CD to calculate the rate and thermodynamic constants due to the indistinguishable concentration dependence of the relaxation frequency. Therefore, first the equilibrium constant was estimated from the concentration dependence of a maximum absorption per wavelength and then the rate constants were calculated. The results obtained were compared with that for the isoleucine and β-CD system. In addition, the rate constant for the formation of the complex was discussed in relation to the diffusion controlled reaction.
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- 2002
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16. Molecular Recognition Kinetics of β-Cyclodextrin for Several Alcohols by Ultrasonic Relaxation Method
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Nishikawa, S., Ugawa, T., and Fukahori, T.
- Abstract
Ultrasonic absorption coefficients in aqueous solutions of 2-propanol, 2-butanol, and 2-methyl-1-propanol (guest) in concentrations less than 0.40 mol dm-3 with β-cyclodextrin (host) in the range below 0.011 mol dm-3 were measured in the frequency range 0.8−95 MHz at 25 °C. A single Debye-type relaxational absorption was found only when both solutes coexisted. From the concentration dependences of the relaxation frequency and the amplitude of the relaxation, the cause of the observed relaxation was attributed to a perturbation of a chemical equilibrium associated with a dynamic interaction between β-cyclodextrin and the alcohols. The rate and thermodynamic parameters for the dynamic interaction were determined, and the results were compared with those for other alcoholic systems with β-cyclodextrin, which were reported previously. The isomeric effect of the guests on the dynamic interaction with β-cyclodextrin was considered and it is deduced from the experimental results that the hydrophobicity of the guests is very sensitive for recognition by the host. Also, an anchor mechanism was proposed for the complexation between the host and guest.
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- 2001
17. Kinetic Study for Molecular Recognition of Amino Acid by Cyclodextrin in Aqueous Solution
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Ugawa, T. and Nishikawa, S.
- Abstract
A system of β-cyclodextrin and
l -isoleucine in aqueous solution was studied by the ultrasonic relaxational method to obtain kinetic parameters for the complexation reaction at 25 °C. Ultrasonic absorption coefficients were measured as a function of frequency in the range 0.8−95 MHz and solute concentration at three different pH's. The frequency dependence of the absorption observed as a function of frequency was analyzed by a Debye-type equation with a single relaxation time at neutral pH. The cause of the relaxation was attributed to a perturbation of a chemical equilibrium due to formation of inclusion complex consisting of β-cyclodextrin andl -isoleucine. The forward and backward rate constants, the equilibrium constant, and the standard volume change of the reaction were determined from the ultrasonic parameters. Comparing these obtained results with those at low pH, it was found that the complexation reaction at low pH is the same as that at neutral pH range. However, at the high pH, another reaction is generated, in addition to the complexation reaction presumably due to a proton transfer reaction. Further, the results for the complexation reaction were compared with those reported previously for several nonelectrolytes, and the structure of amino acid was considered to influence the complexation reaction process considerably, especially the process for the departure of guest from the host cavity.- Published
- 2001
18. Dynamic Interaction between Cyclodextrin and Nonelectrolytes in Aqueous Solutions by Ultrasonic Relaxation Method
- Author
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Nishikawa, S. and Ugawa, T.
- Abstract
Ultrasonic absorption coefficients were measured in aqueous β-cyclodextrin (host) solutions with 1-butyramide (guest), with methyl propionate (guest) and with methyl butyrate (guest) by pulse and resonance methods in the frequency range from 0.8 to 95 MHz at 25 °C. The cause of a single relaxational absorption observed was ascribed to a perturbation of a chemical equilibrium associated with β-cyclodextrin and nonelectrolyte interaction. From the concentration dependence of the ultrasonic parameters, the rate and equilibrium constants were determined. These results were compared with those reported already in other systems with β-cyclodextrin and were discussed in relation to the β-cyclodextrin and guest molecular structures. It was found that the interactions of β-cyclodextrin with the nonelectrolytes were dependent on the characteristics of hydrophobicity and functional group of the guests.
- Published
- 2000
19. ESICM LIVES 2016: part three : Milan, Italy. 1-5 October 2016
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Velasquez, T., Mackey, G., Lusk, J., Kyle, Ug, Fontenot, T., Marshall, P., Shekerdemian, Ls, Coss-Bu, Ja, Nishigaki, A., Yatabe, T., Tamura, T., Yamashita, K., Yokoyama, M., Ruiz-Rodriguez, Jc, Encina, B., Belmonte, R., Troncoso, I., Tormos, P., Riveiro, M., Baena, J., Sanchez, A., Bañeras, J., Cordón, J., Duran, N., Ruiz, A., Caballero, J., Nuvials, X., Riera, J., Serra, J., Rutten, Am, Ieperen, Sn, Kinderen, Ep, Logten, T., Kovacikova, L., Skrak, P., Zahorec, M., Akcan-Arikan, A., Silva, Jc, Goldsworthy, M., Wood, D., Harrison, D., Parslow, R., Davis, P., Pappachan, J., Goodwin, S., Ramnarayan, P., Chernyshuk, S., Yemets, H., Zhovnir, V., Pulitano, Sm, Rosa, S., Mancino, A., Villa, G., Tosi, F., Franchi, P., Conti, G., Patel, B., Khine, H., Shah, A., Sung, D., Singer, L., Haghbin, S., Inaloo, S., Serati, Z., Idei, M., Nomura, T., Yamamoto, N., Sakai, Y., Yoshida, T., Matsuda, Y., Yamaguchi, Y., Takaki, S., Yamaguchi, O., Goto, T., Longani, N., Medar, S., Abdel-Aal, Ir, El Adawy, As, Mohammed, Hm, Mohamed, An, Parry, Sm, Knight, Ld, Denehy, L., Morton, N., Baldwin, Ce, Sani, D., Kayambu, G., Da Silva, Vz, Phongpagdi, P., Puthucheary, Za, Granger, Cl, Rydingsward, Je, Horkan, Cm, Christopher, Kb, Mcwilliams, D., Jones, C., Reeves, E., Atkins, G., Snelson, C., Aitken, Lm, Rattray, J., Kenardy, J., Hull, Am, Ullman, A., Le Brocque, R., Mitchell, M., Davis, C., Macfarlane, B., Azevedo, Jc, Rocha, Ll, Freitas, Ff, Cavalheiro, Am, Lucinio, Nm, Lobato, Ms, Ebeling, G., Kraegpoeth, A., Laerkner, E., Brito-Ashurst, I., White, C., Gregory, S., Forni, Lg, Flowers, E., Curtis, A., Wood, Ca, Siu, K., Venkatesan, K., Muhammad, Jb, Ng, L., Seet, E., Baptista, N., Escoval, A., Tomas, E., Agrawal, R., Mathew, R., Varma, A., Dima, E., Charitidou, E., Perivolioti, E., Pratikaki, M., Vrettou, C., Giannopoulos, A., Zakynthinos, S., Routsi, C., Atchade, E., Houzé, S., Jean-Baptiste, S., Thabut, G., Genève, C., Tanaka, S., Lortat-Jacob, B., Augustin, P., Desmard, M., Montravers, P., Molina, Fj, Barbadillo, S., Alejandro, R., Álvarez-Lerma, F., Vallés, J., Catalán, Rm, Palencia, E., Jareño, A., Granada, Rm, Ignacio, Ml, Getgag, Working Group, Cui, N., Liu, D., Wang, H., Su, L., Qiu, H., Li, R., Jaffal, K., Rouzé, A., Poissy, J., Sendid, B., Nseir, S., Paramythiotou, E., Rizos, M., Frantzeskaki, F., Antoniadou, A., Vourli, S., Zerva, L., Armaganidis, A., Gottlieb, J., Greer, M., Wiesner, O., Martínez, M., Acuña, M., Rello, J., Welte, T., Mignot, T., Soussi, S., Dudoignon, E., Ferry, A., Chaussard, M., Benyamina, M., Alanio, A., Touratier, S., Chaouat, M., Lafaurie, M., Mimoun, M., Mebazaa, A., Legrand, M., Sheils, Ma, Patel, C., Mohankumar, L., Akhtar, N., Noriega, Sk, Aldana, Nn, León, Jl, Baquero, Jd, Bernal, Ff, Ahmadnia, E., Hadley, Js, Millar, M., Hall, D., Hewitt, H., Yasuda, H., Sanui, M., Komuro, T., Kawano, S., Andoh, K., Yamamoto, H., Noda, E., Hatakeyama, J., Saitou, N., Okamoto, H., Kobayashi, A., Takei, T., Matsukubo, S., Jseptic, Clinical Trial Group, 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If, Soler, Ea, Vera, Ap, Pastor, Ee, Hernandis, V., Ros Martínez, J., Rubio, Rj, Torner, Mm, Brugger, Sc, Eroles, Aa, Moles, Si, Cabello, Jt, Schoenenberger, Ja, Casals, Xn, Vidal, Mv, Garrido, Bb, Martinez, Mp, Mirabella, L., Cotoia, A., Tullo, L., Stella, A., Di Bello, F., Di Gregorio, A., Dambrosio, M., Cinnella, G., Ramirez, Jr, Takahashi, H., Kazutoshi, F., Okada, Y., Oobayashi, W., Naito, T., Baidya, Dk, Maitra, S., Anand, Rk, Ray, Br, Arora, Mk, Ruffini, C., Rota, L., Corona, A., Sesana, G., Ravasi, S., Catena, E., Naumann, Dn, Mellis, C., Husheer, Sl, Bishop, J., Midwinter, Mj, Hutchings, S., Manca, T., Ramelli, A., Nicolini, F., Gherli, T., Vezzani, A., Young, A., Carmona, Af, Santiago, Ai, Guillamon, Ln, Delgado, Mj, Delgado-Amaya, M., Curiel-Balsera, E., Rivera-Romero, L., Carrero-Gómez, F., Aguayo-Dehoyos, E., Ariam, Registry Of Adult Cardiac Surgery, Healey, Aj, Cameron, C., Jiao, Lr, Pérez, A., Martin, S., Del Moral, Ol, Toval, S., Rico, J., Aldecoa, C., Oguzhan, K., Demirkiran, O., Kirman, M., Bozbay, S., Kosuk, Me, Asyralyyeva, G., Dilek, M., Duzgun, M., Telli, S., Aydin, M., Yilmazer, F., Hodgson, Le, Dimitrov, Bd, Stubbs, C., Venn, R., Vedage, D., Shawaf, S., Naran, P., Sirisena, N., Kinnear, J., Londoño, Jg, Cardenas, Cl, Ginés, As, Gubianas, Cm, Sánchez, Ec, Sirvent, Jm, Panafidina, V., Shlyk, I., Ilyina, V., Judickas, S., Kezyte, G., Urbanaviciute, I., Serpytis, M., Gaizauskas, E., Sipylaite, J., Sprung, Cl, Munteanu, G., Morales, Rc, Kasdan, H., Volker, T., Reiter, A., Cohen, Y., Himmel, Y., Meissonnier, J., Banderas-Bravo, Me, Gómez-Jiménez, C., García-Martínez, Mv, Martínez-Carmona, Jf, Fernández-Ortega, Jf, O Dwyer, Mj, Starczewska, M., Wilks, M., Rapid Diagnosis of Infections in the Critically Ill Team, Torsvik, M., Gustad, Lt, Bangstad, Il, Vinje, Lj, Damås, Jk, Solligård, E., Mehl, A., Tsunoda, M., Kang, M., Saito, M., Saito, N., Akizuki, N., Namiki, M., Takeda, M., Yuzawa, J., Yaguchi, A., Tokyo Womens Medical University, Tsirigotis, P., Chondropoulos, S., Theodorakopoulou, M., Stamouli, M., Gkirkas, K., Dimopoulou, Ik, Makiko, S., Akiduki, N., Preau, S., Ambler, M., Sigurta, A., Saeed, S., Jochmans, S., Chelly, J., Vong, Lv, Sy, O., Serbource-Goguel, J., Rolin, N., Weyer, Cm, Abdallah, Ri, Adrie, C., Vinsonneau, C., Monchi, M., Mayr, U., Huber, W., Karsten, E., Lahmer, T., Thies, P., Henschel, B., Fischer, G., Schmid, Rm, Naz, I., Yaman, G., Kou, Ps, Lozano, Ja, Sánchez, Pc, Francioni, Je, Ferrón, Fr, Simón, Jm, Riad, Z., Mezidi, M., Aublanc, M., Perinel, S., Lissonde, F., Louf-Durier, A., Yonis, H., Tapponnier, R., Louis, B., Guérin, C., Plug, Working Group, Marmanidou, K., Oikonomou, M., Loizou, C., Somhorst, P., Hayashi, K., Hirayama, T., Yumoto, T., Tsukahara, K., Iida, A., Nosaka, N., Sato, K., Ugawa, T., Nakao, A., Ujike, Y., Hirohata, S., Mojoli, F., Torriglia, F., Giannantonio, M., Orlando, A., Bianzina, S., Mongodi, S., Pozzi, M., Iotti, Ga, Braschi, A., Jansen, D., Gadgil, S., Doorduin, J., Roesthuis, L., Heunks, Lm, Chen, Gq, Sun, Xm, He, X., Yang, Yl, Shi, Zh, Xu, M., Zhou, Jx, Pereira, Sm, Tucci, MR, Tonelotto, Bf, Simoes, Cm, Morais, Cc, Pompeo, Ms, Kay, Fu, Amato, Mb, Vieira, Je, Suzuki, S., Mihara, Y., Hikasa, Y., Okahara, S., Morimatsu, H., Okayama Research Investigation Organizing Network (ORION)investigators, Kwon, Hm, Moon, Yj, Lee, Sh, Jung, Kw, Shin, Wj, Jun, Ig, Song, Jg, Hwang, Gs, Lee, S., Jung, K., Brianti, R., Fanzaghi, P., Tudor, Ba, Klaus, Da, Lebherz-Eichinger, D., Lechner, C., Schwarz, C., Bodingbauer, M., Seemann, R., Kaczirek, K., Fleischmann, E., Roth, Ga, Krenn, Cg, Malyshev, A., Sergey, S., Yoshitake, E., Kaneko, M., Tencé, N., Zaien, I., Wolf, M., Trouiller, P., Jacobs, Fm, Kelly, Jm, Veigas, P., Hollands, S., Min, A., Rizoli, S., Robles, Cm, Oca Sandoval, Ma, Tarabrin, O., Gavrychenko, D., Mazurenko, G., Tarabrin, P., Mendez, Mc, Orden, Va, Noval, Rl, Mccue, C., Gemmell, L., Luján, J., Villa, P., Llorente, B., Molina, R., Alcázar, L., Juanas, Ca, Rogero, S., Pascual, T., Cambronero, Ja, Almudévar, Pm, Domínguez, Jp, Castañeda, Dp, Lucendo, Ap, Rivas, Rf, Villamizar, Pr, Javadpour, S., Kalani, N., Amininejad, T., Jamali, S., Sobhanian, S., Laurent, A., Bonnet, M., Rigal, R., Aslanian, P., Hebert, P., Capellier, G., Ps-Icu, Group, Contreras, MR, Mejías, Cr, Ruiz, Fc, Lombardo, Md, Perez, Jc, Hoyos, Ea, Estella, A., Viciana, R., Fontaiña, Lp, Rico, T., Madueño, Vp, Recuerda, M., Fernández, L., Bonet, S., Mazo, C., Rubiera, M., Ruiz-Rodríguez, Jc, Gracia, Rm, Espinel, E., Pont, T., Kotsopoulos, A., Jansen, N., Abdo, Wf, Gopcevic, A., Gavranovic, Z., Vucic, M., Glogoski, Mz, Penavic, Lv, Horvat, A., Martin-Villen, L., Egea-Guerero, Jj, Revuelto-Rey, J., Aldabo-Pallas, T., Correa-Chamorro, E., Gallego-Corpa, Ai, Granados, Pr, Faivre, V., Wildenberg, L., Huot, B., Lukaszewicz, Ac, Simsir, M., Mengelle, C., Payen, D., La Fuente, Mv, Almudena, Pm, Muñoz, Jj, Abellan, An, Lucendo, Ma, Perez, Lp, Dominguez, Jp, Wee, S., Ong, C., Lau, Yh, Wong, Y., Olea-Jiménez, V., Mora-Ordóñez, Jm, Muñoz-Muñoz, Jl, Vallejo-Báez, J., Daga-Ruiz, D., Lebrón-Gallardo, M., Rialp, G., Raurich, Jm, Morán, I., Martín, Mc, Heras, G., Mas, A., Vallverdú, I., Hraiech, S., Bourenne, J., Guervilly, C., Forel, Jm, Adda, M., Sylla, P., Mouaci, A., Gainnier, M., Papazian, L., Bauer, Pr, Kumbamu, A., Wilson, Me, Pannu, Jk, Egginton, Js, Kashyap, R., Gajic, O., Yoshihiro, S., Sakuraya, M., Hirata, A., Kawamura, N., Tsutui, T., Yoshida, K., Hashimoto, Y., Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group, Chang, Ch, Hu, Hc, Chiu, Lc, Hung, Cy, Li, Sh, Kao, Kc, Sibley, S., Drover, J., D Arsigny, C., Parker, C., Howes, D., Moffatt, S., Erb, J., Ilan, R., Messenger, D., Ball, I., Harrison, M., Ridi, S., Andrade, Ah, Costa, Rc, Souza, Va, Gonzalez, V., Amorim, V., Rolla, F., Filho, Ca, Miranda, R., Atchasiri, S., Buranavanich, P., Wathanawatthu, T., Suwanpasu, S., Bureau, C., Rolland-Debord, C., Poitou, T., Clavel, M., Perbet, S., Kouatchet, A., Similowski, T., Demoule, A., Diaz, P., Nunes, J., Escórcio, S., Silva, G., Chaves, S., Jardim, M., Câmara, M., Fernandes, N., Duarte, R., Jardim, Jj, Pereira, Ca, Nóbrega, Jj, Chen, Cm, Lai, Cc, Cheng, Kc, Chou, W., Lee, Sj, Cha, Ys, Lee, Wy, Onodera, M., Nakataki, E., Oto, J., Imanaka, H., Nishimura, M., Khadjibaev, A., Sabirov, D., Rosstalnaya, A., Akalaev, R., Parpibaev, F., Antonucci, E., Rossini, P., Gandolfi, S., Montini, E., Orlando, S., Nes, M., Karachi, F., Hanekom, S., Pereira, Uv, Parkin, Ms, Moore, M., Carvalho, Kv, Min, Hj, Kim, Hj, Choi, Yy, Lee, Ey, Song, I., Kim, Dj, E, Yy, Kim, Jw, Park, Js, Lee, Jh, Suh, Jw, Jo, Yh, Ferrero-Calleja, J., Merino-Vega, D., González-Jiménez, Ai, Sigcha, Ms, Hernández-Tejedor, A., Martin-Vivas, A., Gabán-Díez, Á, Luna, Rr, La Calle-Pedrosa, N., Temprano-Gómez, I., Afonso-Rivero, D., Pellin-Ariño, Ji, Algora-Weber, A., Fumis, Rr, Ferraz, Ab, Junior, Jm, Kirca, H., Cakin, O., Unal, M., Mutlu, H., Ramazanoglu, A., Cengiz, M., Nicolini, Ea, Pelisson, Fg, Nunes, Rs, Da Silva, Sl, Carreira, Mm, Bellissimo-Rodrigues, F., Ferez, Ma, Basile-Filho, A., Chao, Hc, Chen, L., Hravnak, M., Clermont, G., Pinsky, M., Dubrawski, A., Varas, Jl, Montero, Rm, Sánchez-Elvira, La, Díaz, Pv, Delgado, Cp, Ruiz, Bl, Guerrero, Ap, Galache, Ja, Sherif, H., Hassanin, H., El Hossainy, R., Samy, W., Ly, H., David, H., Burtin, P., Charpentier, C., Barral, M., Courant, P., Fournel, E., Gaide-Chevronnay, L., Durand, M., Albaladejo, P., Payen, Jf, Chavanon, O., Ortiz, Ab, Pozzebon, S., Fumagalli, F., Scala, S., Affatato, R., Maglie, M., Zani, D., Novelli, D., Marra, C., Luciani, A., Luini, M., Letizia, T., Pravettoni, D., Staszewsky, L., Belloli, A., Di Giancamillo, M., Scanziani, E., Kye, Yc, Yu, Km, Babini, G., Grassi, L., Reinikainen, M., Skrifvars, M., Kappler, F., Blobner, M., Schaller, Sj, Roasio, A., Costanzo, E., Cardellino, S., Fontana, V., Park, M., You, Km, Ko, Sb, Beane, A., Thilakasiri, Mc, Silva, Ap, Stephens, T., Sigera, Cs, Athapattu, P., Jayasinghe, S., Padeniya, A., Haniffa, R., Sáez, Vc, Ruiz-Ruano, Rdel, González, As, Kunze-Szikszay, N., Wand, S., Klapsing, P., Wetz, A., Heyne, T., Schwerdtfeger, K., Troeltzsch, M., Bauer, M., Quintel, M., Moerer, O., Cook, Dj, Rutherford, Wb, Scales, Dc, Adhikari, Nk, Cuthbertson, Bh, Suzuki, T., Fushimi, K., Iwamoto, M., Nakagawa, S., Mendsaikhan, N., Begzjav, T., Lundeg, G., Dünser, Mw, Romero, Dg, Padilla, Ys, Kleinpell, R., Chouris, I., Radu, V., Stougianni, M., Lavrentieva, A., Lagonidis, D., Price, Rd, Day, A., Arora, N., Henderson, Ma, Hickey, S., Costa, Mi, Carvalho, Jp, Gomes, Aa, Mergulhão, Pj, Chan, Kk, Maghsoudi, B., Tabei, Sh, Sabetian, G., Tabatabaei, Hr, Akbarzadeh, A., Student Research Committee - Shiraz University of Medical Sciences, Saigal, S., Pakhare, A., Joshi, R., Pattnaik, Sk, Ray, B., Rousseau, Af, Michel, L., Bawin, M., Cavalier, E., Reginster, Jy, Damas, P., Bruyere, O., Zhou, Jc, Cauwenberghs, H., Backer, A., Neels, H., Deblier, I., Berghmans, J., Himpe, D., Barea-Mendoza, Ja, Portillo, Ip, Fernández, Mv, Gigorro, Rg, Vela, Jl, Mateos, Hm, Alves, Sc, Varas, Gm, Rodriguez-Biendicho, A., Carreño, Er, González, Jc, Yang, Js, Lin, Kl, Choi, Yj, Yoon, Sz, Gordillo-Brenes, A., Fernandez-Zamora, Md, Herruzo-Aviles, A., Garcia-Delgado, M., Hinojosa-Perez, R., ARIAM-ANDALUCIA, Pascual, Oa, Pérez, Ag, Fernández, Pa, Amor, Ll, Albaiceta, Gm, Calvo, Sa, Spazzadeschi, A., Marrazzo, F., Gandola, A., Sciurti, R., Savi, C., Tseng, Cj, Bertini, P., Sanctis, F., Guarracino, F., Baldassarri, R., Buitinck, Sh, Voort, Ph, Tsunano, Y., Izawa, M., Tane, N., Ghosh, S., Gupta, A., Gasperi, A., Mazza, E., Limuti, R., Prosperi, M., Bissenova, N., Yergaliyeva, A., Talan, L., Yılmaz, G., Güven, G., Yoruk, F., Altıntas, Nd, Mukherjee, Dn, Agarwal, Lk, Mandal, K., Balsera, B., Martinez, M., Garcia, M., Castellana, D., Lopez, R., Barcenilla, F., Kaminsky, Ge, Carreño, R., Escribá, A., Fuentes, M., Gálvez, V., Del Olmo, R., Nieto, B., Vaquerizo, C., Alvarez, J., La Torre, Ma, Torres, E., Bogossian, E., Nouer, Sa, Salgado, Dr, Jiménez, Gj, Gaite, Fb, Martínez, Mp, Doganci, M., Izdes, S., Besevli, Sg, Alkan, A., Kayaaslan, B., Penichet, Sm, López, Ma, Repessé, X., Artiguenave, M., Paktoris-Papine, S., Espinasse, F., Dinh, A., El Sayed, F., Charron, C., Géri, G., Vieillard-Baron, A., Dimitroulakis, K., Ferré, A., Guillot, M., Teboul, Jl, Lichtenstein, D., Mézière, G., Richard, C., Monnet, X., Prīdāne, S., Sabeļņikovs, O., Bianchi, I., Kondili, E., Psarologakis, C., Kokkini, S., Amargianitakis, V., Babalis, D., Chytas, A., Chouvarda, I., Vaporidi, K., Georgopoulos, D., Trapp, O., Kalenka, A., Karbing, Ds, Gioia, A., Moro, F., Corte, Fd, Mauri, T., Rees, Se, Plug working group, Petrova, Mv, Mohan, R., Butrov, Av, Beeharry, Sd, Vatsik, Mv, Sakieva, Fi, Gobert, F., Fernandez, R., Labaune, Ma, Burle, Jf, Barbier, J., Vincent, B., Cleyet, M., Shinotsuka, Cr, Törnblom, S., Nisula, S., Vaara, S., Poukkanen, M., Andersson, S., Pesonen, E., Xie, Z., Liao, X., Kang, Y., Zhang, J., Kubota, K., Egi, M., Mizobuchi, S., Hegazy, S., El-Keraie, A., El Sayed, E., El Hamid, Ma, Rodrigues, Nj, Pereira, M., Godinho, I., Gameiro, J., Neves, M., Gouveia, J., E Silva, Zc, Lopes, Ja, Mckinlay, J., Kostalas, M., Kooner, G., Dudas, G., Horton, A., Kerr, C., Karanjia, N., Creagh-Brown, B., Yamazaki, A., Ganuza, Ms, Molina, Ja, Martinez, Fh, Freile, Mt, Fernandez, Ng, Travieso, Pm, Bandert, A., Frithiof, R., Lipcsey, M., Smekal, D., Schlaepfer, P., Durovray, Jd, Plouhinec, V., Chiappa, C., Bellomo, R., Schneider, Ag, Mitchell, S., Durrant, J., Street, H., Dunthorne, E., Shears, J., Caballero, Ch, Hutchison, R., Schwarze, S., Ghabina, S., Thompson, E., Prowle, Jr, Kirwan, Cj, Gonzalez, Ca, Pinto, Jl, Orozco, V., Patiño, Ja, Garcia, Pk, Contreras, Km, Rodriguez, P., and Echeverri, Je
20. ESICM LIVES 2016: part three
- Author
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Velasquez, T., Mackey, G., Lusk, J., Kyle, U. G., Fontenot, T., Marshall, P., Shekerdemian, L. S., Coss-Bu, J. A., Nishigaki, A., Yatabe, T., Tamura, T., Yamashita, K., Yokoyama, M., Ruiz-Rodriguez, J. C., Encina, B., Belmonte, R., Troncoso, I., Tormos, P., Riveiro, M., Baena, J., Sanchez, A., Bañeras, J., Cordón, J., Duran, N., Ruiz, A., Caballero, J., Nuvials, X., Riera, J., Serra, J., Rutten, A. M. F., van Ieperen, S. N. M., Der Kinderen, E. P. H. M., Van Logten, T., Kovacikova, L., Skrak, P., Zahorec, M., Akcan-Arikan, A., Silva, J. C., Goldsworthy, M., Wood, D., Harrison, D., Parslow, R., Davis, P., Pappachan, J., Goodwin, S., Ramnarayan, P., Chernyshuk, S., Yemets, H., Zhovnir, V., Pulitano’, S. M., De Rosa, S., Mancino, A., Villa, G., Tosi, F., Franchi, P., Conti, G., Patel, B., Khine, H., Shah, A., Sung, D., Singer, L., Haghbin, S., Inaloo, S., Serati, Z., Idei, M., Nomura, T., Yamamoto, N., Sakai, Y., Yoshida, T., Matsuda, Y., Yamaguchi, Y., Takaki, S., Yamaguchi, O., Goto, T., Longani, N., Medar, S., Abdel-Aal, I. R., El Adawy, A. S., Mohammed, H. M. E. H., Mohamed, A. N., Parry, S. M., Knight, L. D., Denehy, L., De Morton, N., Baldwin, C. E., Sani, D., Kayambu, G., da Silva, V. Z. M., Phongpagdi, P., Puthucheary, Z. A., Granger, C. L., Rydingsward, J. E., Horkan, C. M., Christopher, K. B., McWilliams, D., Jones, C., Reeves, E., Atkins, G., Snelson, C., Aitken, L. M., Rattray, J., Kenardy, J., Hull, A. M., Ullman, A., Le Brocque, R., Mitchell, M., Davis, C., Macfarlane, B., Azevedo, J. C., Rocha, L. L., De Freitas, F. F. M., Cavalheiro, A. M., Lucinio, N. M., Lobato, M. S., Ebeling, G., Kraegpoeth, A., Laerkner, E., De Brito-Ashurst, I., White, C., Gregory, S., Forni, L. G., Flowers, E., Curtis, A., Wood, C. A., Siu, K., Venkatesan, K., Muhammad, J. B. H., Ng, L., Seet, E., Baptista, N., Escoval, A., Tomas, E., Agrawal, R., Mathew, R., Varma, A., Dima, E., Charitidou, E., Perivolioti, E., Pratikaki, M., Vrettou, C., Giannopoulos, A., Zakynthinos, S., Routsi, C., Atchade, E., Houzé, S., Jean-Baptiste, S., Thabut, G., Genève, C., Tanaka, S., Lortat-Jacob, B., Augustin, P., Desmard, M., Montravers, P., de Molina, F. J. González, Barbadillo, S., Alejandro, R., Álvarez-Lerma, F., Vallés, J., Catalán, R. M., Palencia, E., Jareño, A., Granada, R. M., Ignacio, M. L., Cui, N., Liu, D., Wang, H., Su, L., Qiu, H., Li, R., Jaffal, K., Rouzé, A., Poissy, J., Sendid, B., Nseir, S., Paramythiotou, E., Rizos, M., Frantzeskaki, F., Antoniadou, A., Vourli, S., Zerva, L., Armaganidis, A., Gottlieb, J., Greer, M., Wiesner, O., Martínez, M., Acuña, M., Rello, J., Welte, T., Mignot, T., Soussi, S., Dudoignon, E., Ferry, A., Chaussard, M., Benyamina, M., Alanio, A., Touratier, S., Chaouat, M., Lafaurie, M., Mimoun, M., Mebazaa, A., Legrand, M., Sheils, M. A., Patel, C., Mohankumar, L., Akhtar, N., Noriega, S. K. Pacheco, Aldana, N. Navarrete, León, J. L. Ávila, Baquero, J. Durand, Bernal, F. Fernández, Ahmadnia, E., Hadley, J. S., Millar, M., Hall, D., Hewitt, H., Yasuda, H., Sanui, M., Komuro, T., Kawano, S., Andoh, K., Yamamoto, H., Noda, E., Hatakeyama, J., Saitou, N., Okamoto, H., Kobayashi, A., Takei, T., Matsukubo, S., Rotzel, H. B., Lázaro, A. Serrano, Prada, D. Aguillón, Gimillo, M. Rodriguez, Barinas, O. Diaz, Cortes, M. L. Blasco, Franco, J. Ferreres, Roca, J. M. Segura, Carratalá, A., Gonçalves, B., Turon, R., Mendes, A., Miranda, F., Mata, P. J., Cavalcanti, D., Melo, N., Lacerda, P., Kurtz, P., Righy, C., Rosario, L. E. de la Cruz, Lesmes, S. P. Gómez, Romero, J. C. García, Herrera, A. N. García, Pertuz, E. D. Díaz, Sánchez, M. J. Gómez, Sanz, E. Regidor, Hualde, J. Barado, Hernández, A. Ansotegui, Irazabal, J. M. Guergué, Spatenkova, V., Bradac, O., Suchomel, P., Urli, T., Lazzeri, E. Heusch, Aspide, R., Zanello, M., Perez-Borrero, L., Garcia-Alvarez, J. M., Arias-Verdu, M. D., Aguilar-Alonso, E., Rivera-Fernandez, R., Mora-Ordoñez, J., De La Fuente-Martos, C., Castillo-Lorente, E., Guerrero-Lopez, F., Rosario, L. E. De la Cruz, Ramírez, J. Roldán, León, J. P. Tirapu, Navarro-Guillamón, L., Cordovilla-Guardia, S., Iglesias-Santiago, A., Guerrero-López, F., Fernández-Mondéjar, E., Vidal, A., Perez, M., Juez, A., Arias, N., Colino, L., Perez, J. L., Pérez, H., Calpe, P., Alcala, M. A., Robaglia, D., Perez, C., Lan, S. 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D., Stubbs, C., Venn, R., Vedage, D., Shawaf, S., Naran, P., Sirisena, N., Kinnear, J., Londoño, J. Gonzalez, Cardenas, C. Lorencio, Ginés, A. Sánchez, Gubianas, C. Murcia, Sánchez, E. Clapes, Sirvent, J. M., Panafidina, V., Shlyk, I., Ilyina, V., Judickas, S., Kezyte, G., Urbanaviciute, I., Serpytis, M., Gaizauskas, E., Sipylaite, J., Sprung, C. L., Munteanu, G., Morales, R. C., Kasdan, H., Volker, T., Reiter, A., Cohen, Y., Himmel, Y., Meissonnier, J., Banderas-Bravo, M. E., Gómez-Jiménez, C., García-Martínez, M. V., Martínez-Carmona, J. F., Fernández-Ortega, J. F., O‘Dwyer, M. J., Starczewska, M., Wilks, M., Torsvik, M., Gustad, L. T., Bangstad, I. L., Vinje, L. J., Damås, J. K., Solligård, E., Mehl, A., Tsunoda, M., Kang, M., Saito, M., Saito, N., Akizuki, N., Namiki, M., Takeda, M., Yuzawa, J., Yaguchi, A., Tsirigotis, P., Chondropoulos, S., Theodorakopoulou, M., Stamouli, M., Gkirkas, K., Dimopoulou, I. K., Makiko, S., Akiduki, N., Preau, S., Ambler, M., Sigurta, A., Saeed, S., Jochmans, S., Chelly, J., Vong, L. V. P., Sy, O., Serbource-Goguel, J., Rolin, N., Weyer, C. M., Abdallah, R. I., Adrie, C., Vinsonneau, C., Monchi, M., Mayr, U., Huber, W., Karsten, E., Lahmer, T., Thies, P., Henschel, B., Fischer, G., Schmid, R. M., Naz, I., Yaman, G., Kou, P. S., Lozano, J. A. Benítez, Sánchez, P. Carmona, Francioni, J. E. Barrueco, Ferrón, F. Ruiz, Simón, J. M. Serrano, Riad, Z., Mezidi, M., Aublanc, M., Perinel, S., Lissonde, F., Louf-Durier, A., Yonis, H., Tapponnier, R., Richard, J. C., Louis, B., Guérin, C., Marmanidou, K., Oikonomou, M., Loizou, C., Somhorst, P., Hayashi, K., Hirayama, T., Yumoto, T., Tsukahara, K., Iida, A., Nosaka, N., Sato, K., Ugawa, T., Nakao, A., Ujike, Y., Hirohata, S., Mojoli, F., Torriglia, F., Giannantonio, M., Orlando, A., Bianzina, S., Mongodi, S., Pozzi, M., Iotti, G. A., Braschi, A., Jansen, D., Gadgil, S., Doorduin, J., Roesthuis, L., Heunks, L. M. A., Chen, G. Q., Sun, X. M., He, X., Yang, Y. L., Shi, Z. H., Xu, M., Zhou, J. X., Pereira, S. M., Tucci, M. R., Tonelotto, B. F. F., Simoes, C. M., Morais, C. C. A., Pompeo, M. S., Kay, F. U., Amato, M. B. P., Vieira, J. E., Suzuki, S., Mihara, Y., Hikasa, Y., Okahara, S., Morimatsu, H., Kwon, H. M., Moon, Y. J., Lee, S. H., Jung, K. W., Shin, W. J., Jun, I. G., Song, J. G., Hwang, G. S., Lee, S., Jung, K., Brianti, R., Fanzaghi, P., Tudor, B. A., Klaus, D. A., Lebherz-Eichinger, D., Lechner, C., Schwarz, C., Bodingbauer, M., Seemann, R., Kaczirek, K., Fleischmann, E., Roth, G. A., Krenn, C. G., Malyshev, A., Sergey, S., Yoshitake, E., Kaneko, M., Tencé, N., Zaien, I., Wolf, M., Trouiller, P., Jacobs, F. M., Kelly, J. M., Veigas, P., Hollands, S., Min, A., Rizoli, S., Robles, C. M. Coronado, de Oca Sandoval, M. A. Montes, Tarabrin, O., Gavrychenko, D., Mazurenko, G., Tarabrin, P., Mendez, M. Casado, orden, V. Arellano, Noval, R. Leal, McCue, C., Gemmell, L., Luján, J., Villa, P., Llorente, B., Molina, R., Alcázar, L., Juanas, C. Arenillas, Rogero, S., Pascual, T., Cambronero, J. A., Almudévar, P. Matía, Domínguez, J. Palamidessi, Carmona, S. Alcántara, Castañeda, D. Palacios, Lucendo, A. Pérez, Rivas, R. Fernández, Villamizar, P. Rodríguez, Javadpour, S., Kalani, N., Amininejad, T., Jamali, S., Sobhanian, S., Laurent, A., Bonnet, M., Rigal, R., Aslanian, P., Hebert, P., Capellier, G., Contreras, M. R. Diaz, Mejías, C. Rodriguez, Ruiz, F. C. Santiago, Lombardo, M. Duro, Perez, J. Castaño, de Hoyos, E. Aguayo, Estella, A., Viciana, R., Fontaiña, L. Perez, Rico, T., Madueño, V. Perez, Recuerda, M., Fernández, L., Bonet, S., Mazo, C., Rubiera, M., Ruiz-Rodríguez, J. C., Gracia, R. M., Espinel, E., Pont, T., Kotsopoulos, A., Jansen, N., Abdo, W. F., Gopcevic, A., Gavranovic, Z., Vucic, M., Glogoski, M. Zlatic, Penavic, L. Videc, Horvat, A., Martin-Villen, L., Egea-Guerero, J. J., Revuelto-Rey, J., Aldabo-Pallas, T., Correa-Chamorro, E., Gallego-Corpa, A. I., Granados, P. Ruiz del Portal-Ruiz, Faivre, V., Wildenberg, L., Huot, B., Lukaszewicz, A. C., Simsir, M., Mengelle, C., Payen, D., Sanz, N. Martinez, de la Fuente, M. Valdivia, Almudena, P. Matía, Abellán, A. Navarro, Muñoz, J. J. Rubio, Abellan, A. Naharro, Lucendo, M. A. Perez, Perez, L. Perez, Dominguez, J. Palamidessi, Rivas, R. Fernandez, Villamizar, P. Rodriguez, Wee, S., Ong, C., Lau, Y. H., Wong, Y., Olea-Jiménez, V., Mora-Ordóñez, J. M., Muñoz-Muñoz, J. L., Vallejo-Báez, J., Daga-Ruiz, D., Lebrón-Gallardo, M., Rialp, G., Raurich, J. M., Morán, I., Martín, M. C., Heras, G., Mas, A., Vallverdú, I., Hraiech, S., Bourenne, J., Guervilly, C., Forel, J. M., Adda, M., Sylla, P., Mouaci, A., Gainnier, M., Papazian, L., Bauer, P. R., Kumbamu, A., Wilson, M. E., Pannu, J. K., Egginton, J. S., Kashyap, R., Gajic, O., Yoshihiro, S., Sakuraya, M., Hirata, A., Kawamura, N., Tsutui, T., Yoshida, K., Hashimoto, Y., Chang, C. H., Hu, H. C., Chiu, L. C., Hung, C. Y., Li, S. H., Kao, K. C., Sibley, S., Drover, J., D’Arsigny, C., Parker, C., Howes, D., Moffatt, S., Erb, J., Ilan, R., Messenger, D., Ball, I., Harrison, M., Ridi, S., Andrade, A. H., Costa, R. C., Souza, V. A., Gonzalez, V., Amorim, V., Rolla, F., Filho, C. A. C. Abreu, Miranda, R., Atchasiri, S., Buranavanich, P., Wathanawatthu, T., Suwanpasu, S., Bureau, C., Rolland-Debord, C., Poitou, T., Clavel, M., Perbet, S., Kouatchet, A., Similowski, T., Demoule, A., Diaz, P., Nunes, J., Escórcio, S., Silva, G., Chaves, S., Jardim, M., Câmara, M., Fernandes, N., Duarte, R., Jardim, J. J., Pereira, C. A., Nóbrega, J. J., Chen, C. M., Lai, C. C., Cheng, K. C., Chou, W., Lee, S. J., Cha, Y. S., Lee, W. Y., Onodera, M., Nakataki, E., Oto, J., Imanaka, H., Nishimura, M., Khadjibaev, A., Sabirov, D., Rosstalnaya, A., Akalaev, R., Parpibaev, F., Antonucci, E., Rossini, P., Gandolfi, S., Montini, E., Orlando, S., van Nes, M., Karachi, F., Hanekom, S., Pereira, U. V., Parkin, M. S. W., Moore, M., Carvalho, K. V. Silva, Min, H. J., Kim, H. J., Choi, Y. Y., Lee, E. Y., Song, I., Kim, D. J., E, Y. Y., Kim, J. W., Park, J. S., Lee, J. H., Suh, J. W., Jo, Y. H., Ferrero-Calleja, J., Merino-Vega, D., González-Jiménez, A. I., Sigcha, M. Sigcha, Hernández-Tejedor, A., Martin-Vivas, A., Gabán-Díez, Á., Luna, R. Ruiz-de, De la Calle-Pedrosa, N., Temprano-Gómez, I., Afonso-Rivero, D., Pellin-Ariño, J. I., Algora-Weber, A., Fumis, R. R. L., Ferraz, A. B., Junior, J. M. Vieira, Kirca, H., Cakin, O., Unal, M., Mutlu, H., Ramazanoglu, A., Cengiz, M., Nicolini, E. A., Pelisson, F. G. F., Nunes, R. S., da Silva, S. L., Carreira, M. M., Bellissimo-Rodrigues, F., Ferez, M. A., Basile-Filho, A., Chao, H. C., Chen, L., Hravnak, M., Clermont, G., Pinsky, M., Dubrawski, A., Varas, J. Luján, Montero, R. Molina, Sánchez-Elvira, L. Alcázar, Díaz, P. Villa, Delgado, C. Pintado, Ruiz, B. Llorente, Guerrero, A. Pardo, Galache, J. A. Cambronero, Sherif, H., Hassanin, H., El Hossainy, R., Samy, W., Ly, H., David, H., Burtin, P., Charpentier, C., Barral, M., Courant, P., Fournel, E., Gaide-Chevronnay, L., Durand, M., Albaladejo, P., Payen, J. F., Chavanon, O., Ortiz, A. Blandino, Pozzebon, S., Fumagalli, F., Scala, S., Affatato, R., De Maglie, M., Zani, D., Novelli, D., Marra, C., Luciani, A., De Zani, D., Luini, M., Letizia, T., Pravettoni, D., Staszewsky, L., Belloli, A., Di Giancamillo, M., Scanziani, E., Kye, Y. C., Yu, K. M., Babini, G., Grassi, L., Reinikainen, M., Skrifvars, M., Kappler, F., Blobner, M., Schaller, S. J., Roasio, A., Costanzo, E., Cardellino, S., Fontana, V., Park, M., You, K. M., Ko, S. B., Beane, A., Thilakasiri, M. C. K. T., De Silva, A. P., Stephens, T., Sigera, C. S., Athapattu, P., Jayasinghe, S., Padeniya, A., Haniffa, R., Sáez, V. Chica, Ruiz-Ruano, R. de la Chica, González, A. Sánchez, Kunze-Szikszay, N., Wand, S., Klapsing, P., Wetz, A., Heyne, T., Schwerdtfeger, K., Troeltzsch, M., Bauer, M., Quintel, M., Moerer, O., Cook, D. J., Rutherford, W. B., Scales, D. C., Adhikari, N. K., Cuthbertson, B. H., Suzuki, T., Fushimi, K., Iwamoto, M., Nakagawa, S., Mendsaikhan, N., Begzjav, T., Lundeg, G., Dünser, M. W., Romero, D. González, Padilla, Y. Santana, Kleinpell, R., Chouris, I., Radu, V., Stougianni, M., Lavrentieva, A., Lagonidis, D., Price, R. D. T., Day, A., Arora, N., Henderson, M. A., Hickey, S., Costa, M. I. Almeida, Carvalho, J. P., Gomes, A. A., Mergulhão, P. J., Chan, K. K. C., Maghsoudi, B., Tabei, S. H., Sabetian, G., Tabatabaei, H. R., Akbarzadeh, A., Saigal, S., Pakhare, A., Joshi, R., Pattnaik, S. K., Ray, B., Rousseau, A. F., Michel, L., Bawin, M., Cavalier, E., Reginster, J. Y., Damas, P., Bruyere, O., Zhou, J. C., Cauwenberghs, H., De Backer, A., Neels, H., Deblier, I., Berghmans, J., Himpe, D., Barea-Mendoza, J. A., Portillo, I. Prieto, Fernández, M. Valiente, Gigorro, R. Garcia, Vela, J. L. Perez, Mateos, H. Marín, Alves, S. Chacón, Varas, G. Morales, Rodriguez-Biendicho, A., Carreño, E. Renes, González, J. C. Montejo, Yang, J. S., Lin, K. L., Choi, Y. J., Yoon, S. Z., Gordillo-Brenes, A., Fernandez-Zamora, M. D., Herruzo-Aviles, A., Garcia-Delgado, M., Hinojosa-Perez, R., Pascual, O. Agudo, Irazabal, J. M. Guergue, Pérez, A. González, Fernández, P. Alvarez, Amor, L. Lopéz, Albaiceta, G. Muñiz, Calvo, S. Aldunate, Spazzadeschi, A., Marrazzo, F., Gandola, A., Sciurti, R., Savi, C., Tseng, C. J., Bertini, P., De Sanctis, F., Guarracino, F., Baldassarri, R., Buitinck, S. H., van der Voort, P. H. J., Tsunano, Y., Izawa, M., Tane, N., Ghosh, S., Gupta, A., De Gasperi, A., Mazza, E., Limuti, R., Prosperi, M., Bissenova, N., Yergaliyeva, A., Talan, L., Yılmaz, G., Güven, G., Yoruk, F., Altıntas, N. D., Mukherjee, D. N., Agarwal, L. K., Mandal, K., Balsera, B., Martinez, M., Garcia, M., Castellana, D., Lopez, R., Barcenilla, F., Kaminsky, G. E., Carreño, R., Escribá, A., Fuentes, M., Gálvez, V., Del Olmo, R., Nieto, B., Vaquerizo, C., Alvarez, J., De la Torre, M. A., Torres, E., Bogossian, E., Nouer, S. Aranha, Salgado, D. Ribeiro, Jiménez, G. Jiménez, Vidal, M. Vallverdú, Gaite, F. Barcenilla, Martínez, M. Palomar, Doganci, M., Izdes, S., Besevli, S. Guzeldag, Alkan, A., Kayaaslan, B., Penichet, S. M. Marrero, López, M. A. De La Cal, Santana, S. Ruíz, Repessé, X., Artiguenave, M., Paktoris-Papine, S., Espinasse, F., Dinh, A., El Sayed, F., Charron, C., Géri, G., Vieillard-Baron, A., Dimitroulakis, K., Ferré, A., Guillot, M., Teboul, J. L., Lichtenstein, D., Mézière, G., Richard, C., Monnet, X., Prīdāne, S., Sabeļņikovs, O., Bianchi, I., Kondili, E., Psarologakis, C., Kokkini, S., Amargianitakis, V., Babalis, D., Chytas, A., Chouvarda, I., Vaporidi, K., Georgopoulos, D., Trapp, O., Kalenka, A., Karbing, D. S., Gioia, A., Moro, F., Corte, F. Dalla, Mauri, T., Rees, S. E., Petrova, M. V., Mohan, R., Butrov, A. V., Beeharry, S. D., Vatsik, M. V., Sakieva, F. I., Gobert, F., Fernandez, R., Labaune, M. A., Burle, J. F., Barbier, J., Vincent, B., Cleyet, M., Shinotsuka, C. Righy, Törnblom, S., Nisula, S., Vaara, S., Poukkanen, M., Andersson, S., Pesonen, E., Xie, Z., Liao, X., Kang, Y., Zhang, J., Kubota, K., Egi, M., Mizobuchi, S., Hegazy, S., El-Keraie, A., El Sayed, E., El Hamid, M. Abd, Rodrigues, N. J., Pereira, M., Godinho, I., Gameiro, J., Neves, M., Gouveia, J., e Silva, Z. Costa, Lopes, J. A., Mckinlay, J., Kostalas, M., Kooner, G., Dudas, G., Horton, A., Kerr, C., Karanjia, N., Creagh-Brown, B., Yamazaki, A., Ganuza, M. Sanz, Molina, J. A. Martinez, Martinez, F. Hidalgo, Freile, M. T. Chiquito, Fernandez, N. Garcia, Travieso, P. Medrano, Bandert, A., Frithiof, R., Lipcsey, M., Smekal, D., Schlaepfer, P., Durovray, J. D., Plouhinec, V., Chiappa, C., Bellomo, R., Schneider, A. G., Mitchell, S., Durrant, J., Street, H., Dunthorne, E., Shears, J., Caballero, C. Hernandez, Hutchison, R., Schwarze, S., Ghabina, S., Thompson, E., Prowle, J. R., Kirwan, C. J., Gonzalez, C. A., Pinto, J. L., Orozco, V., Patiño, J. A., Garcia, P. K., Contreras, K. M., Rodriguez, P., and Echeverri, J. E.
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Meeting Abstracts - Full Text
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21. Effect of antiemetics on zolbetuximab-induced gastric injury and emesis in ferrets.
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Kinugasa F, Kajikawa S, Weng J, Ugawa T, Fushiki H, Yamanaka Y, Nagata M, Haggerty G, Akuzawa S, Nakazawa T, Suzuki H, and Sawamoto T
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- Animals, Antibodies, Monoclonal adverse effects, Antibodies, Monoclonal pharmacology, Morpholines pharmacology, Male, Dexamethasone adverse effects, Nausea chemically induced, Female, Ferrets, Vomiting chemically induced, Antiemetics pharmacology, Antiemetics therapeutic use, Gastric Mucosa drug effects, Gastric Mucosa pathology
- Abstract
Claudin-18 splice variant 2 (CLDN18.2), a tight junction protein, is a highly cell type-specific antigen that is expressed by differentiated gastric mucosa cells. The expression of CLDN18.2 in gastric mucosa cells may be retained upon malignant transformation and is displayed on the surface of several tumors, including gastric/gastroesophageal junction adenocarcinoma. Zolbetuximab is a genetically engineered, highly purified chimeric (mouse/human IgG1) antibody directed against CLDN18.2. Nausea and vomiting were observed as adverse events of zolbetuximab. To investigate the mechanism of nausea and vomiting in humans, we evaluated emesis (retching and vomiting) and conducted histopathologic assessment in ferrets after the administration of zolbetuximab. Emesis was frequently observed in all ferrets treated with zolbetuximab in the first hour after administration. Histopathologic assessment revealed the surface of the gastric mucosa was the primary site of emesis-associated tissue damage. The effect of antiemetics (dexamethasone, ondansetron, fosaprepitant, and olanzapine) on emesis induced by zolbetuximab was investigated. Fosaprepitant showed suppressive effects on emesis, and use of dexamethasone or concomitant use of fosaprepitant with other antiemetics tended to alleviate gastric tissue damage. The onset of emesis in humans receiving zolbetuximab may be associated with damage in the gastric mucosa, and antiemetics may mitigate gastrointestinal adverse events., Competing Interests: Declaration of competing interest All authors are employees of Astellas Pharma, Inc. or its affiliates., (Copyright © 2024 The Authors. Production and hosting by Elsevier B.V. All rights reserved.)
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- 2024
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22. Pharmacokinetic/pharmacodynamic modeling of roxadustat's effect on LDL cholesterol in patients in Japan with dialysis-dependent chronic kidney disease and anemia.
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Takada A, Shibata T, Shiga T, Ugawa T, Komatsu K, and Akizawa T
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- Humans, Cholesterol, LDL, Renal Dialysis, Japan, Sevelamer, Hydroxymethylglutaryl-CoA Reductase Inhibitors pharmacology, Hydroxymethylglutaryl-CoA Reductase Inhibitors therapeutic use, Anemia drug therapy, Renal Insufficiency, Chronic drug therapy
- Abstract
Aims: The objective of this analysis was to develop and evaluate a pharmacokinetic/pharmacodynamic (PK/PD) model of the effect of roxadustat on low-density lipoprotein cholesterol (LDL-C) in Japanese patients with anemia of dialysis-dependent chronic kidney disease while considering the impact of covariates on model parameters., Methods: A total of 2330 LDL-C measurements from 275 patients in 3 clinical studies were analyzed using a nonlinear-mixed effects modeling approach in NONMEM software., Results: The PK/PD relationship between roxadustat exposure and LDL-C was well described by a kinetic-pharmacodynamic model with a physiological indirect response model as the PD component. Co-administered statin usage, sevelamer usage, type of dialysis (hemodialysis or peritoneal dialysis), and sex were selected as covariates for LDL
baseline . Weight was selected as a covariate for ID50. Imax and ID50 were estimated as 0.661 and 1.51 mg/h, respectively., Conclusion: Roxadustat can decrease LDL-C independent of statins and sevelamer. Further study of the ability of roxadustat to lower LDL-C and any potential effects on outcomes is needed., Competing Interests: Declaration of competing interest AT is an employee of Astellas Pharma Global Development, Inc., Illinois, United States. TShibata reports personal fees from Astellas. TShiga is an employee of Astellas Pharma, Inc., Tokyo, Japan. TU reports personal fees from Astellas. KK reports personal fees from Astellas. TA reports personal fees from Astellas, Kyowa Kirin, Japan Tabaco, Bayer, GlaxoSmithKline, Ono Pharmaceutical, Torii Pharmaceutical, Fuso Pharmaceutical, Kissei Pharmaceutical, Sanwa Chemical, Otsuka Pharmaceutical, Nipro, and Chugai Pharmaceutical., (Copyright © 2022 The Japanese Society for the Study of Xenobiotics. Published by Elsevier Ltd. All rights reserved.)- Published
- 2022
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23. Hydrodynamic Approach for Revealing Venous Anastomotic Stenosis Formation Within a Dialysis Arteriovenous Graft.
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Sano Y, Ugawa T, Takeda A, Hyakutake T, Nakazawa T, Yanase S, Shigemitsu H, and Arai H
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- Anastomosis, Surgical adverse effects, Blood Flow Velocity, Constriction, Pathologic etiology, Humans, Renal Dialysis adverse effects, Arteriovenous Shunt, Surgical adverse effects, Hydrodynamics
- Abstract
A conventional arteriovenous graft in patients on dialysis often leads to anastomotic stenosis, which decreases the blood flow rate and increases the risk of complications. In this study, based on hydrodynamics, the pulsatile pressure at the blood vessel graft-vein junction was investigated experimentally and numerically for revealing the causes of stenosis formation and inward remodeling. In the experiments, the pulsatile pressure and displacement at the anastomotic connection were measured at a branched collapsible tube. It was revealed that the pressure becomes negative between pressure peaks of the pulsatile flow; furthermore, tube diameter changes in accordance with the pressure pulsation. Subsequently, numerical simulations revealed that a relatively large pressure difference occurs at the anastomotic connection because of flow collision and separation as compared with the other part, and the pulsatile pressure. Therefore, it is possible that vein at an anastomotic connection may change its shape under pulsating flow. Furthermore, it was found that the pressure difference slightly increased with the anastomosis angle, but the anastomosis angle did not affect the flow rate. Clinical trials in the next step are required to reveal the causal relationship between stenosis and the pulsatile pressure, but the pulsatile flow and its pressure are likely to be one factor in stenosis and inward remodeling., Competing Interests: Disclosure: The authors have no conflicts of interest to report., (Copyright © ASAIO 2021.)
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- 2021
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24. Arterial and Venous Thrombosis Complicated in COVID-19: A Retrospective Single Center Analysis in Japan.
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Oba S, Hosoya T, Amamiya M, Mitsumura T, Kawata D, Sasaki H, Kamiya M, Yamamoto A, Ando T, Shimada S, Shirai T, Okamoto T, Tateishi T, Endo A, Aiboshi J, Nosaka N, Yamanouchi H, Ugawa T, Nagaoka E, Oi K, Tao S, Maejima Y, Tanaka Y, Tanimoto K, Takeuchi H, Tohda S, Hirakawa A, Sasano T, Arai H, Otomo Y, Miyazaki Y, and Yasuda S
- Abstract
Background: Thrombosis is a characteristic complication in coronavirus disease 2019 (COVID-19). Since coagulopathy has been observed over the entire clinical course, thrombosis might be a clue to understanding the specific pathology in COVID-19. Currently, there is limited epidemiological data of COVID-19-associated thrombosis in the Japanese population and none regarding variant strains of SARS-CoV-2. Here, we elucidate the risk factors and the pattern of thrombosis in COVID-19 patients. Methods: The patients consecutively admitted to Tokyo Medical and Dental University Hospital with COVID-19 were retrospectively analyzed. SARS-CoV-2 variants of concern/interest (VOC/VOI) carrying the spike protein mutants E484K, N501Y, or L452R were identified by PCR-based analysis. All thrombotic events were diagnosed by clinical symptoms, ultrasonography, and/or radiological tests. Results: Among the 516 patients, 32 patients experienced 42 thromboembolic events. Advanced age, severe respiratory conditions, and several abnormal laboratory markers were associated with the development of thrombosis. While thrombotic events occurred in 13% of the patients with a severe respiratory condition, those events still occurred in 2.5% of the patients who did not require oxygen therapy. Elevated D-dimer and ferritin levels on admission were independent risk factors of thrombosis (adjusted odds ratio 9.39 and 3.11, 95% confidence interval 2.08-42.3, and 1.06-9.17, respectively). Of the thrombotic events, 22 were venous, whereas 20 were arterial. While patients with thrombosis received anticoagulation and antiinflammatory therapies with a higher proportion, the mortality rate, organ dysfunctions, and bleeding complications in these patients were higher than those without thrombosis. The incidence of thrombosis in COVID-19 became less frequent over time, such as during the replacement of the earlier strains of SARS-CoV-2 by VOC/VOI and during increased use of anticoagulatory therapeutics. Conclusion: This study elucidated that elevated D-dimer and ferritin levels are useful biomarkers of thrombosis in COVID-19 patients. The comparable incidence of arterial thrombosis with venous thrombosis and the development of thrombosis in less severe patients required further considerations for the management of Japanese patients with COVID-19. Further studies would be required to identify high-risk populations and establish appropriate interventions for thrombotic complications in COVID-19., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Oba, Hosoya, Amamiya, Mitsumura, Kawata, Sasaki, Kamiya, Yamamoto, Ando, Shimada, Shirai, Okamoto, Tateishi, Endo, Aiboshi, Nosaka, Yamanouchi, Ugawa, Nagaoka, Oi, Tao, Maejima, Tanaka, Tanimoto, Takeuchi, Tohda, Hirakawa, Sasano, Arai, Otomo, Miyazaki and Yasuda.)
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- 2021
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25. Efficacy of multidisciplinary team approach with extracorporeal membrane oxygenation for COVID-19 in a low volume ECMO center.
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Nagaoka E, Arai H, Ugawa T, Masuda T, Ochiai K, Tamaoka M, Kurashima N, Oi K, Fujiwara T, Yoshida M, Shigemitsu H, and Otomo Y
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- Adult, Aged, COVID-19 diagnosis, COVID-19 mortality, COVID-19 physiopathology, Cooperative Behavior, Female, Hospital Mortality, Humans, Interdisciplinary Communication, Male, Middle Aged, Recovery of Function, Respiration, Artificial, Retrospective Studies, Time Factors, Time-to-Treatment, Tokyo, Treatment Outcome, COVID-19 therapy, Extracorporeal Membrane Oxygenation adverse effects, Extracorporeal Membrane Oxygenation mortality, Hospitals, Low-Volume, Patient Care Team
- Abstract
Veno-venous extracorporeal membrane oxygenation (VV ECMO) is an effective and proven adjunct support for various severe respiratory failures requiring invasive mechanical ventilation and cardiovascular support. In response to the rapidly increasing number of COVID-19 patients in Japan, we launched an ECMO support team comprised of multidisciplinary experts including physicians, nurses, perfusionists, and bioethicists in preparation for the threat of a pandemic. From April 2 to July 15, 2020, Tokyo Medical and Dental University hospital treated 104 PCR confirmed COVID-19 patients. Among those, 34 patients were admitted to intensive care unit (ICU) and 5 patients required VV ECMO. All management related to ECMO was decided by the ECMO support team in addition to participation of the ECMO support team in daily multidisciplinary rounds in the ICU. Median age was 54 years old. Duration from onset to mechanical ventilation (MV) and MV to ECMO were 8 and 7 days, respectively. Four patients (80%) were successfully weaned off from ECMO. One patient died after 81 days of ECMO run. Four patients were discharged and recovered to their prehospital quality of life without major disability. We achieved a high survival rate using ECMO in our low volume ECMO institution during the COVID-19 pandemic. Multidisciplinary decision-making and a team approach for the unclear pathology with an emerging infectious disease was effective and contributed to the survival rate., (© 2021 International Center for Artificial Organs and Transplantation and Wiley Periodicals LLC.)
- Published
- 2021
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26. Analytical Solutions of a Two-Compartment Model Based on the Volume-Average Theory for Blood Toxin Concentration during and after Dialysis.
- Author
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Sano Y, Sato K, Iida R, Kabashima N, and Ugawa T
- Abstract
Accurate prediction of blood toxin concentration during and after dialysis will greatly contribute to the determination of dialysis treatment conditions. Conventional models, namely single-compartment model and two-compartment model, have advantages and disadvantages in terms of accuracy and practical application. In this study, we attempted to derive the mathematical model that predicts blood toxin concentrations during and after dialysis, which has both accuracy and practicality. To propose the accurate model, a new two-compartment model was mathematically derived by adapting volume-averaging theory to the mass transfer around peripheral tissues. Subsequently, to propose a practical model for predicting the blood toxin concentration during dialysis, an analytical solution expressed as algebraic expression was derived by adopting variable transformation. Furthermore, the other analytical solution that predicts rebound phenomena after dialysis was also derived through similar steps. The comparisons with the clinical data revealed that the proposed analytical solutions can reproduce the behavior of the measured blood urea concentration during and after dialysis. The analytical solutions proposed as algebraic expressions will allow a doctor to estimate the blood toxin concentration of a patient during and after dialysis. The proposed analytical solutions may be useful to consider the treatment conditions for dialysis, including the rebound phenomenon.
- Published
- 2021
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27. [Roxadustat (Evrenzo ® tablet), a therapeutic drug for renal anemia: pharmacological characteristics and clinical evidence in Japan].
- Author
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Ugawa T, Ashizaki M, Murata A, and Majikawa Y
- Subjects
- Animals, Glycine analogs & derivatives, Humans, Isoquinolines, Japan, Rats, Tablets, Anemia drug therapy, Anemia etiology, Renal Insufficiency, Chronic drug therapy
- Abstract
Roxadustat (Evrenzo
® tablet) is an oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor. Roxadustat has been approved for the treatment of renal anemia in patients on dialysis in September 2019 in Japan. By inhibiting HIF-PH, roxadustat suppresses the degradation of HIF-α, a subunit of the heterodimeric transcription factor HIF, leading to its accumulation and activation of the HIF pathway. Similar to activation of the HIF pathway in response to hypoxia, the production of endogenous erythropoietin is increased and erythropoiesis is stimulated. Moreover, roxadustat stimulates erythropoiesis efficiently by improving iron bioavailability. The efficacy and mechanism of action of roxadustat have been detailed in non-clinical pharmacology studies. Rat models of anemia demonstrated efficacy of roxadustat in correcting anemia and changes in gene expression leading to increased iron bioavailability. Four phase 3 clinical studies in Japan clearly demonstrated the efficacy of roxadustat in patients with renal anemia on dialysis. Roxadustat showed an acceptable safety profile, and the incidences and types of adverse events and serious adverse events reported in the clinical studies were similar with those predicted to occur in these patient population. Since roxadustat is an oral drug, concerns present with erythropoiesis-stimulating agents (ESAs) such as the risk of infection to the medical staff due to accidental needle-stick, pain during ESA injection in patients and burden on patients to visit a hospital, can be avoided or reduced. In November 2020, roxadustat has also been approved for the treatment of renal anemia in patients not on dialysis (data not shown in this article).- Published
- 2021
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28. Renoprotective effects of the novel prostaglandin EP4 receptor-selective antagonist ASP7657 in 5/6 nephrectomized chronic kidney disease rats.
- Author
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Mizukami K, Yoshida H, Nozawa E, Wada K, and Ugawa T
- Subjects
- Animals, Hemodynamics, Kidney drug effects, Kidney pathology, Male, Nephrectomy, Rats, Wistar, Renal Insufficiency, Chronic blood, Renal Insufficiency, Chronic pathology, Renal Insufficiency, Chronic physiopathology, Renin blood, Indoles therapeutic use, Mesylates therapeutic use, Protective Agents therapeutic use, Quinolines therapeutic use, Receptors, Prostaglandin E, EP4 Subtype antagonists & inhibitors, Renal Insufficiency, Chronic drug therapy
- Abstract
Prostaglandins (PGs) are important lipid mediators of numerous physiologic and pathophysiologic processes in the kidney. PGE
2 , the most abundant renal PG, plays a major role in renal physiology, including renin release and glomerular hemodynamics. We investigated the renoprotective properties of the novel PGE2 EP4 receptor-selective antagonist ASP7657 in 5/6 nephrectomized rats, a chronic kidney disease (CKD) model. Eight weeks of repeated administration of ASP7657 (0.001-0.1 mg/kg) dose-dependently and significantly reduced urinary protein excretion and attenuated the development of glomerulosclerosis and tubulointerstitial damage, including fibrosis and inflammatory cell infiltration, without affecting blood pressure. Additionally, ASP7657 tended to have beneficial effects on renal function, as indicated by the decrease in plasma creatinine and blood urea nitrogen levels and attenuation of the decline in creatinine clearance (Ccr). The angiotensin II receptor blocker losartan (10 mg/kg) also showed these renoprotective effects while significantly reducing blood pressure. ASP7657 dose-dependently and significantly reduced the EP4 receptor agonist-induced increase in plasma renin activity, as assessed by angiotensin I release in normal rats. Additionally, ASP7657 attenuated hyperfiltration assessed by Ccr without changing the renal blood flow or blood pressure in diabetic rats. These results suggest that ASP7657 suppresses the progression of chronic renal failure by modulating renin release and improving renal hemodynamics, and may therefore be a promising therapeutic option for inhibiting the progression of CKD.- Published
- 2019
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29. Pharmacological properties of ASP7657, a novel, potent, and selective prostaglandin EP4 receptor antagonist.
- Author
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Mizukami K, Kamada H, Yoshida H, Ishii I, Nozawa E, Wada K, and Ugawa T
- Subjects
- Albuminuria drug therapy, Animals, CHO Cells, Cell Line, Cricetulus, Cyclic AMP metabolism, Diabetes Mellitus, Type 2 drug therapy, Dinoprostone pharmacology, Humans, Indoles therapeutic use, Male, Mesylates therapeutic use, Mice, Quinolines therapeutic use, Rats, Sprague-Dawley, Receptors, Prostaglandin E, EP4 Subtype metabolism, Tumor Necrosis Factor-alpha blood, Indoles pharmacology, Mesylates pharmacology, Quinolines pharmacology, Receptors, Prostaglandin E, EP4 Subtype antagonists & inhibitors
- Abstract
We determined the pharmacologic profile of ASP7657, trans-4-[({[1-(quinolin-2-ylmethyl)-5-(trifluoromethyl)-1H-indol-7 yl] carbonyl} amino) methyl] cyclohexanecarboxylic acid methanesulfonate (1:1), a newly synthesized selective E-type prostaglandin (EP)4 receptor antagonist using several in vitro and in vivo experiments. ASP7657 exhibited high affinity for rat and human EP4 receptors, with K
i values of 6.02 nM and 2.21 nM, respectively. In addition, ASP7657 potently inhibited the PGE2 -induced cyclic adenosine monophosphate (cAMP) increase in Chinese hamster ovary (CHO) cells expressing rat EP4 receptors and human lymphoblastoid T (Jurkat) cells, with IC50 values of 0.86 nM and 0.29 nM, respectively. In contrast, ASP7657 did not inhibit the PGE2 -induced intracellular calcium increase in HEK293 cells expressing rat EP1 and EP3 receptors, or cAMP increase in CHO cells expressing rat EP2 receptors. ASP7657 showed good pharmacokinetic properties following oral dosing and dose-dependently antagonized the prostaglandin (PG)E2 -mediated inhibition of lipopolysaccharide-induced tumor necrosis factor-α release from rat whole blood culture. In addition, 4 weeks repeated oral administration of ASP7657 dose-dependently attenuated albuminuria in type 2 diabetic mice; these effects were significant at doses of 0.01 mg/kg or higher. These results demonstrate that ASP7657 is a potent and selective EP4 receptor antagonist that may be useful in future studies to help clarify the physiological and pathophysiological roles of PG.- Published
- 2018
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30. AN69ST membranes adsorb nafamostat mesylate and affect the management of anticoagulant therapy: a retrospective study.
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Hirayama T, Nosaka N, Okawa Y, Ushio S, Kitamura Y, Sendo T, Ugawa T, and Nakao A
- Abstract
Background: In Japan, nafamostat mesylate (NM) is frequently used as an anticoagulant during continuous renal replacement therapy (CRRT). The dialyzer membrane AN69ST has been reported to adsorb NM and affect the management of anticoagulant therapy. However, the adsorbed amount has not yet been quantitatively assessed. Therefore, in this study, we evaluated the pre- and post-hemofilter prolongation of the activated clotting time (ACT) in patients with AN69ST and PS membranes. We also measured the adsorption of NM in three types of CRRT membranes using an experimental model., Methods: In a study of patients who underwent CRRT using AN69ST or PS membranes in 2015 at the Advanced Emergency and Critical Care Center, Okayama University Hospital, pre- and post-hemofilter ACT measurements were extracted retrospectively, and the difference was calculated. In addition, AN69ST (sepXiris100), PS (HEMOFEEL SHG-1.0), and PMMA membranes (HEMOFEEL CH-1.0N) were used in an in vitro model of a dialysis circuit, and the concentrations of NM were measured in pre- and post-hemofilter membranes and filtrates., Results: The ACT difference was significantly lower in the group using AN69ST membranes ( p < 0.01). In the in vitro model ( n = 4) with adsorption and filtration, the post-hemofilter and filtrate concentrations of NM in AN69ST membranes were significantly lower than those in the PS and PMMA membranes ( p < 0.01). The NM adsorption clearance of the AN69ST membrane was significantly higher than that of the PS and PMMA membranes., Conclusions: The AN69ST membrane had higher NM adsorption than the PS and PMMA membranes. This may have resulted in the lower ACT difference in patients undergoing CRRT using the AN69ST membrane than in patients undergoing CRRT using PS or PMMA membranes.
- Published
- 2017
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31. Citrobacter braakii bacteremia-induced septic shock after colonoscopy preparation with polyethylene glycol in a critically ill patient: a case report.
- Author
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Yumoto T, Kono Y, Kawano S, Kamoi C, Iida A, Nose M, Sato K, Ugawa T, Okada H, Ujike Y, and Nakao A
- Subjects
- Aged, Asian People, Blood microbiology, Critical Illness, Humans, Male, Polyethylene Glycols administration & dosage, Citrobacter isolation & purification, Enterobacteriaceae Infections chemically induced, Enterobacteriaceae Infections complications, Polyethylene Glycols adverse effects, Shock, Septic etiology, Shock, Septic pathology
- Abstract
Background: Polyethylene glycol (PEG) is widely used for bowel cleaning in preparation for colonoscopy because of its safety. Septic shock after PEG preparation is an extremely rare complication. Herein, we describe a case of septic shock that occurred immediately after colonoscopy preparation with PEG., Case Presentation: A 75-year-old Japanese male who had previously developed diabetes after total pancreatectomy received PEG in preparation for colonoscopy. He had been admitted to the emergency intensive care unit 4 days earlier due to hematochezia presenting with shock. He ingested PEG to prepare for a colonoscopy examination, which was performed to identify the source of his bleeding over a 5-h period, but suddenly exhibited septic shock and markedly elevated procalcitonin levels. A blood culture subsequently revealed Citrobacter braakii. Immediate resuscitation and intensive care with appropriate antibiotics improved his condition., Conclusions: Clinicians should be aware of the possibility of deteriorating conditions after bowel preparation with PEG among severely ill patients with recent episodes of hemorrhagic shock.
- Published
- 2017
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32. Intracranial Pressure Monitoring for Pediatric Acute Encephalopathy.
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Nosaka N, Tsukahara K, Knaup E, Yabuuchi T, Kikkawa T, Fujii Y, Yashiro M, Yasuhara T, Okada A, Ugawa T, Nakao A, Tsukahara H, and Date I
- Subjects
- Acute Disease, Child, Preschool, Critical Care, Female, Humans, Infant, Male, Brain Diseases, Intracranial Pressure physiology, Monitoring, Physiologic methods
- Abstract
Newly published clinical practice guidelines recommend intracranial pressure (ICP) monitoring in critical care for the management of pediatric acute encephalopathy (pAE), but the utility of ICP monitoring for pAE has been poorly studied. We recently performed direct ICP monitoring for two patients. We observed that although the direct ICP monitoring had clinical benefits with less body weight gain and no vasopressor use in both cases, this monitoring technique is still invasive. Future studies should determine the utility of non-invasive ICP monitoring systems in pAE to further improve the quality of intensive-care management., Competing Interests: No potential conflict of interest relevant to this article was reported.
- Published
- 2017
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33. Recurrent apnea in an infant with pertussis due to household transmission.
- Author
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Ochi M, Nosaka N, Knaup E, Tsukahara K, Kikkawa T, Fujii Y, Yashiro M, Sato K, Ugawa T, Okada A, and Tsukahara H
- Abstract
Bordetella pertussis causes life-threatening apnea in infants. Lymphocytosis is an important clue for diagnosis and for determining the severity of pertussis. Antibiotics do not shorten or ameliorate the disease and only decrease the risk of transmission. Antepartum maternal immunization is important for preventing pertussis in infants.
- Published
- 2017
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34. Soft tissue hematoma of the neck due to thyroid rupture with unusual mechanism.
- Author
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Tsukahara K, Sato K, Yumoto T, Iida A, Nosaka N, Terado M, Naito H, Orita Y, Naito T, Miki K, Sugihara M, Nagao S, Ugawa T, and Nakao A
- Abstract
Introduction: Massive bleeding from the thyroid gland causing airway compromise secondary to indirect neck trauma is rare., Presentation of Case: An 89-year-old woman was transferred to our emergency department due to anterior neck pain after a traffic accident. She had been propelled forward and struck her head on the front mirror during emergency braking. Airway patency was confirmed at the first contact. Although her vital signs were stable at presentation, she gradually suffered from respiratory distress and severe dyspnea, implying airway compression, therefore requiring endotracheal intubation. Computed tomography (CT) revealed a large, encapsulated hematoma in the left thyroid gland lobe extending to the upper mediastinum. Contrast-enhanced CT demonstrated an extravasation of the contrast agent around the left superior thyroid artery. The left thyroid artery was ligated and the hematoma was removed immediately. She had a favorable course without further complications and was discharged 36days after admission., Discussion: Airway management is the most important consideration in patients with thyroid injury. Treatment should be customized depending on the degree of respiratory distress resulting from of either involvement of the direct airway or secondary compression., Conclusion: Although hemorrhage from the thyroid gland without blunt trauma is rare, emergency physicians should regard possible thyroid gland rupture in patients with swelling of the neck or acute respiratory failure after direct/indirect trauma to the neck. Observation or operative management for limited or expanding hematoma are appropriately based on fundamental neck trauma principles., (Copyright © 2016 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2016
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35. A case of cricothyroidotomy for facial trauma in a patient taking antiplatelet agents after a simple ground-level fall.
- Author
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Yumoto T, Matsumura T, Tsukahara K, Sato K, Ugawa T, and Ujike Y
- Abstract
Introduction: Cricothyroidotomy is an emergency procedure that can be used to secure the airway in situations in which intubation and ventilation are not possible., Presentation of Case: We describe a case of 79-year-old male presenting with facial trauma combined with massive upper airway bleeding and swelling in which cricothyroidotomy was required to open the airway in an elderly male patient taking antiplatelet agents who suffered a simple ground-level fall., Discussion: Although emergency airway management is often required in patients with Le Fort fractures, mandibular condyle fractures exhibit a significant relationship with ground-level falls, which are not usually associated with emergency airway management. Prophylactic intubation should be considered prior to transfer or deterioration in a trauma patient with dual antiplatelet drugs and fractures of bilateral mandibular condyle., Conclusion: Clinicians should be aware of the life-threatening injuries that can be caused by simple ground-level falls in patients taking antiplatelet agents., (Copyright © 2016 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2016
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36. Superior ophthalmic vein thrombosis associated with severe facial trauma: a case report.
- Author
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Mishima M, Yumoto T, Hashimoto H, Yasuhara T, Iida A, Tsukahara K, Sato K, Ugawa T, Otsuka F, and Ujike Y
- Subjects
- Aged, Facial Injuries diagnostic imaging, Humans, Male, Tomography, X-Ray Computed, Anticoagulants therapeutic use, Facial Injuries complications, Orbit diagnostic imaging, Venous Thrombosis diagnostic imaging, Venous Thrombosis drug therapy, Warfarin therapeutic use
- Abstract
Introduction: Superior ophthalmic vein thrombosis is a rare entity, but is associated with significant morbidities. We describe a case in which superior ophthalmic vein thrombosis occurred shortly after severe facial trauma., Case Presentation: A 77-year-old Japanese man was transferred to our tertiary hospital after a motor vehicle accident. Le Fort III facial bone fractures and a minor cerebral contusion were detected. Follow-up computed tomography scans detected dilatation of his left superior ophthalmic vein on day 3 and thrombosis on day 12; however, no causative carotid cavernous fistula was observed. As he did not present with any symptoms other than slight conjunctival congestion, a conservative management strategy was adopted along with anticoagulant therapy against deep venous thrombosis. The superior ophthalmic vein thrombosis resolved spontaneously and the conjunctival congestion also improved., Conclusions: Superior ophthalmic vein thrombosis should be taken into consideration and managed properly after severe facial injuries, and further investigation of its cause is necessary to prevent morbidities.
- Published
- 2015
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37. An unusual case of a patient who presented with haemorrhagic shock following massive subcutaneous haematomas of the lower back due to blunt trauma.
- Author
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Yumoto T, Sato K, Ugawa T, and Ujike Y
- Subjects
- Accidents, Traffic, Aged, 80 and over, Embolization, Therapeutic, Female, Hematoma therapy, Humans, Iliac Artery, Lumbar Vertebrae blood supply, Resuscitation, Shock, Hemorrhagic therapy, Back Injuries complications, Hematoma etiology, Shock, Hemorrhagic etiology, Subcutaneous Tissue injuries, Wounds, Nonpenetrating complications
- Abstract
An 83-year-old woman with no significant medical history was transferred to our tertiary hospital after being hit by a car and presenting with haemorrhagic shock. Immediate fluid resuscitation was performed; physical, chest/pelvic X-ray and echographic examinations did not detect any major sources of bleeding. However, a contrast-enhanced CT scan revealed multiple regions of significant contrast extravasation in an extensive part of the subcutaneous tissue of the patient's lower back, which is an unusual source of bleeding. Transcatheter arterial embolisation of the lumbar and internal iliac arteries and their branches was carried out. In addition, haemostatic resuscitation was performed for damage control resuscitation, which successfully resolved the patient's haemorrhagic shock., (2015 BMJ Publishing Group Ltd.)
- Published
- 2015
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38. Improved survival with an innovative approach to the treatment of severely burned patients: development of a burn treatment manual.
- Author
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Morisada S, Nosaka N, Tsukahara K, Ugawa T, Sato K, and Ujike Y
- Abstract
The management of severely burned patients remains a major issue worldwide as indicated by the high incidence of permanent debilitating complications and poor survival rates. In April 2012, the Advanced Emergency & Critical Care Medical Center of the Okayama University Hospital began implementing guidelines for severely burned patients, distributed as a standard burn treatment manual. The protocol, developed in-house, was validated by comparing the outcomes of patients with severe extensive burns (SEB) treated before and after implementation of these new guidelines at this institution. The patients included in this study had a burn index (BI) ≥30 or a prognostic burn index (PBI = BI + patient's age) ≥100. The survival rate of the patients with BI ≥30 was 65.2% with the traditional treatment and 100% with the new guidelines. Likewise, the survival rate of the patients with PBI ≥100 was 61.1% with the traditional treatment compared to 100% with the new guidelines. Together, these data demonstrate that the new treatment guidelines dramatically improved the treatment outcome and survival of SEB patients.
- Published
- 2015
39. Ditch-related falls: Need for preventive educational campaigns.
- Author
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Nosaka N, Tsukahara K, Knaup E, Ugawa T, and Ujike Y
- Published
- 2015
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40. Three cases of heparin-induced thrombocytopenia associated with polytrauma.
- Author
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Yumoto T, Sato K, Fujii N, Kinami Y, Tsukahara K, Ugawa T, Ichiba S, and Ujike Y
- Abstract
Case: We present three cases in which patients that had suffered polytrauma developed heparin-induced thrombocytopenia after the start of heparin treatment for thrombosis. All three patients had high injury severity scores and required major surgery. They all started receiving unfractionated heparin for deep venous thrombosis with or without an asymptomatic pulmonary embolism. The patients were clinically diagnosed with heparin-induced thrombocytopenia after their platelet counts fell or exhibited a delayed recovery., Outcome: Heparin-induced thrombocytopenia and the associated thromboses were successfully treated by discontinuing all forms of heparin treatment and administering argatroban followed by warfarin., Conclusion: Early recognition and clinical diagnosis of heparin-induced thrombocytopenia is necessary for clinicians in cases in which severely injured trauma patients show reductions or delayed recovery in their platelet counts in combination with thrombosis after starting heparin treatment.
- Published
- 2015
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41. Characteristics and Costs of Ladder Fall Injuries: A Report from a Single Emergency Center in Okayama.
- Author
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Nosaka N, Goda Y, Knaup E, Tsukahara K, Yumoto T, Ugawa T, and Ujike Y
- Subjects
- Adult, Aged, Aged, 80 and over, Cost of Illness, Female, Health Care Costs, Humans, Male, Middle Aged, Patient Education as Topic, Accidental Falls economics
- Abstract
We sought to identify the incidence, injury patterns, and financial burden of ladder fall injuries to provide a reference for reinforcing guidelines on the prevention of such injuries. We enrolled the patients who were injured in a ladder-related fall and required intensive care between April 2012 and March 2014 at Okayama University Hospital, a tertiary care hospital in Okayama City:9 patients injured in 7 stepladder falls and 2 straight ladder falls. The median patient age was 69 years, and 8 were males. Six falls occurred in non-occupational settings. Head injuries predominated, and the injury severity score ranged from 2 to 35 (mean=21±12). At the time of discharge from the intensive care unit, one patient had died and 5 patients had some neurological disabilities. The case fatality rate was 11%. The total cost of care during the review period was ¥16,705,794, with a mean cost of ¥1,856,199 per patient. Ladder fall injuries are associated with a high rate of neurological sequelae and pose a financial burden on the health insurance system. A prevention education campaign targeting at older-aged males in non-occupational settings may be a worthwhile health service investment in this community.
- Published
- 2015
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42. Tetanus in a 19-year-old Japanese Woman.
- Author
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Hagiya H, Hirayama T, Ugawa T, and Otsuka F
- Published
- 2015
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43. Prevalence, risk factors, and short-term consequences of traumatic brain injury-associated hyponatremia.
- Author
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Yumoto T, Sato K, Ugawa T, Ichiba S, and Ujike Y
- Subjects
- Adolescent, Adult, Aged, Female, Humans, Hyponatremia epidemiology, Intensive Care Units, Length of Stay, Male, Middle Aged, Prevalence, Retrospective Studies, Risk Factors, Brain Injuries complications, Hyponatremia etiology
- Abstract
Hyponatremia, a common electrolyte disorder associated with traumatic brain injuries (TBIs), has high mortality and morbidity rates. The aim of this study was to identify the risk factors for hyponatremia associated with TBI. We retrospectively analyzed the cases of TBI patients who were admitted to the emergency intensive care unit at Okayama University Hospital between October 2011 and September 2014. A total of 82 TBI patients were enrolled. The incidences of hyponatremia (serum sodium level of<135mEq/L) and severe hyponatremia (serum sodium level of<130mEq/L) within the first 14 days after admission were 51% (n=42) and 20% (n=16), respectively. After admission, hyponatremia took a median period of 7 days to develop and lasted for a median of 3 days. Multivariate analysis demonstrated that higher fluid intake from days 1 to 3 and the presence of cranial fractures were risk factors for hyponatremia. The 58 patients with hyponatremia experienced fewer ventilator-free days, longer intensive care unit stays, and less favorable outcomes compared to the 24 patients without hyponatremia;however, these differences were not significant. Further studies are needed to determine the optimal management strategy for TBI-associated hyponatremia in the intensive care unit setting.
- Published
- 2015
- Full Text
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44. Septic shock due to Aeromonas hydrophila bacteremia in a patient with alcoholic liver cirrhosis: a case report.
- Author
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Yumoto T, Ichiba S, Umei N, Morisada S, Tsukahara K, Sato K, Ugawa T, and Ujike Y
- Subjects
- Aged, Bacteremia microbiology, Gram-Negative Bacterial Infections microbiology, Humans, Male, Shock, Septic microbiology, Aeromonas hydrophila isolation & purification, Bacteremia complications, Gram-Negative Bacterial Infections complications, Liver Cirrhosis, Alcoholic complications, Shock, Septic complications
- Abstract
Introduction: Aeromonas hydrophila sometimes causes bacteremia, which can be fatal in compromised patients, such as those with liver cirrhosis. We present a case of septic shock due to Aeromonas hydrophila bacteremia in a patient with liver cirrhosis, which was successfully treated with rapid resuscitation and critical care., Case Presentation: A 71-year-old Japanese man with liver cirrhosis was transported to our emergency center by ambulance after presenting with gait difficulties and fever. On arrival, he exhibited shock and severe lactic acidosis, which was suggestive of sepsis, and was immediately resuscitated and administered empiric antibiotic therapy. He also displayed catecholamine-resistant hypotension, which was successfully treated with critical care including supportive therapies, such as polymyxin B hemoperfusion and cytokine-absorbing hemofiltration. Aeromonas hydrophila was detected in his initial blood cultures., Conclusions: Aeromonas septicemia should be considered in patients with alcoholic liver cirrhosis who have profound shock. In addition to goal-directed therapy and the prompt administration of empiric antibiotic therapy, aggressive critical care involving multiple supportive therapies can save such patients.
- Published
- 2014
- Full Text
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45. Mean lung pressure during adult high-frequency oscillatory ventilation: an experimental study using a lung model.
- Author
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Hirayama T, Nagano O, Shiba N, Yumoto T, Sato K, Terado M, Ugawa T, Ichiba S, and Ujike Y
- Subjects
- Adult, Equipment Design, Humans, Inhalation physiology, Respiration, Artificial instrumentation, Respiration, Artificial methods, Stroke Volume physiology, Air Pressure, High-Frequency Ventilation instrumentation, High-Frequency Ventilation methods, Lung physiology, Models, Biological, Models, Structural
- Abstract
In adult high-frequency oscillatory ventilation (HFOV), stroke volume (SV) and mean lung pressure (PLung) are important for lung protection. We measured the airway pressure at the Y-piece and the lung pressure during HFOV using a lung model and HFOV ventilators for adults (R100 and 3100B). The lung model was made of a 20-liter, airtight rigid plastic container (adiabatic compliance: 19.3 ml/cmH2O) with or without a resistor (20 cmH2O/l/sec). The ventilator settings were as follows: mean airway pressure (MAP), 30 cmH2O; frequency, 5-15 Hz (every 1 Hz); airway pressure amplitude (AMP), maximum;and % of inspiratory time (IT), 50% for R100, 33% or 50% for 3100B. The measurements were also performed with an AMP of 2/3 or 1/3 maximum at 5, 10 and 15 Hz. The PLung and the measured MAP were not consistently identical to the setting MAP in either ventilator, and decreasing IT decreased the PLung in 3100B. In conclusion, we must pay attention to the possible discrepancy between the PLung and the setting MAP during adult HFOV.
- Published
- 2014
- Full Text
- View/download PDF
46. Immediate screening method for predicting the necessity of massive transfusions in trauma patients: a retrospective single-center study.
- Author
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Yumoto T, Iida A, Hirayama T, Tsukahara K, Shiba N, Yamanouchi H, Sato K, Ugawa T, Ichiba S, and Ujike Y
- Abstract
Background: Hemostatic resuscitation might improve the survival of severely injured trauma patients. Our objective was to establish a simplified screening system for determining the necessity of massive transfusions (MT) at an early stage in trauma cases., Methods: We retrospectively analyzed the cases of trauma patients who had been transported to our institution between November 2011 and October 2013. Patients who were younger than 18 years of age or who were confirmed to have suffered a cardiac arrest at the scene or on arrival were excluded. MT were defined as transfusions involving the delivery of ≥10 units of red blood cell concentrate within the first 24 h after arrival., Results: A total of 259 trauma patients were included in this study (males: 178, 69%). Their mean age was 49 ± 20, and their median injury severity score was 14.4. Thirty-three (13%) of the patients required MT. The presence of a shock index of ≥1, a base excess of ≤ -3 mmol/L, or a positive focused assessment of sonography for trauma (FAST) result was found to exhibit sensitivity and specificity values of 0.97 and 0.81, respectively, for predicting the necessity of MT. Furthermore, this method displayed an area under the receiver operating characteristic curve of 0.934 (95% confidence interval, 0.891-0.978), which indicated that it was highly accurate., Conclusions: Our screening method based on the shock index, base excess, and FAST result is a simple and useful way of predicting the necessity of MT early after trauma.
- Published
- 2014
- Full Text
- View/download PDF
47. Characteristics and costs of ditch-related injuries: a report from a single emergency center in Okayama.
- Author
-
Nosaka N, Fujita Y, Morisada S, Ugawa T, and Ujike Y
- Abstract
Aim: This study was designed to identify the incidence, injury patterns, and financial burden of ditch-related injuries to provide a reference for establishing guidelines on the prevention of such injuries., Methods: A retrospective chart review in a tertiary care hospital in Okayama city, Japan, focused on patients injured following a ditch-related fall and requiring intensive care between April 2012 and August 2013. Analysis was carried out to describe the epidemiology of ditch-related injuries., Results: Thirteen patients (median age, 60 years) met the inclusion criteria. The median time lag between the fall and rescue was approximately 1.5 h. Ten patients were injured in residential areas, and three were injured in rural areas. Eight patients were riding a bicycle at the time of the accident. Head and spine injuries predominated, although there were two cases of drowning, of which one died. The injury severity score ranged from 1 to 50 (mean, 17.8 ± 13). At the time of discharge from the intensive care unit, 6, 4, and 1 patients were classified into cerebral performance categories 1, 3, and 4, respectively. There were two in-hospital deaths, resulting in a case fatality rate of 15.3%. The total cost during the review period was ¥27,572,630, with a mean cost of ¥2,120,971 per patient., Conclusion: Ditch-related injuries are associated with a high rate of poor neurological outcome and pose a financial burden on the health insurance system. Injury prevention efforts directed at decreasing the risk of ditch-related falls are required to minimize these outcomes.
- Published
- 2014
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48. A new classification system for evaluating patients with severe trauma using B-type natriuretic peptide levels and estimated glomerular filtration rate.
- Author
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Morisada S, Ugawa T, Nosaka N, and Ujike Y
- Subjects
- APACHE, Adolescent, Adult, Aged, Aged, 80 and over, Biomarkers blood, Female, Heart physiology, Humans, Kidney physiology, Male, Middle Aged, Survival Rate, Wounds and Injuries blood, Wounds and Injuries physiopathology, Young Adult, Glomerular Filtration Rate physiology, Natriuretic Peptide, Brain blood, Trauma Severity Indices, Wounds and Injuries classification
- Abstract
Current systems for the evaluation of trauma severity are tedious and difficult to apply in an actual emergency setting. We aimed to develop and assess the accuracy of a more efficient severity evaluation system, termed the Ugawa classification, using brain-type natriuretic peptide (BNP) measurement and the estimated glomerular filtration rate (eGFR). Two-hundred trauma patients were divided into 2 groups using an eGFR cut-off value of 90ml/min/1.73m2 as an indicator of normal renal function and 2 additional groups according to whether the BNP values were greater or less than the age in years. This resulted in 4 subject groups with different combinations of eGFR and BNP. The mean SOFA score, injury severity scores (ISS), trauma and injury severity scores (TRISS), and Acute Physiology and Chronic Health Evaluation II (APACHE II) scores of the groups were compared by Kruskal-Wallis test, and the mortality rate after 90 days was calculated. Significant intergroup differences were found in SOFA scores, ISS scores, and APACHE II-predicted mortality rates. Although no significant differences were found in the mortality rate after 90 days or TRISS-predicted mortality rate among the 4 groups, there was a trend toward increasing trauma severity from group 1 to 4. Thus, the Ugawa classification is as accurate as existing systems, has greater efficiency, and is user-friendly.
- Published
- 2014
- Full Text
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49. Evaluating the need for and effect of percutaneous transluminal angioplasty on arteriovenous fistulas by using total recirculation rate per dialysis session ("clearance gap").
- Author
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Ugawa T, Sakurama K, Yorifuji T, Takaoka M, Fujiwara Y, Kabashima N, Azuma D, Hirayama T, Tsukahara K, Morisada S, Iida A, Tada K, Shiba N, Sato N, Ichiba S, Kino K, Fukushima M, and Ujike Y
- Subjects
- Aged, Blood Flow Velocity, Female, Humans, Male, Middle Aged, Angioplasty, Arteriovenous Fistula therapy, Radial Artery physiopathology, Renal Dialysis methods
- Abstract
The functioning of an arteriovenous fistula (AVF) used for vascular access during hemodialysis has been assessed mainly by dilution methods. Although these techniques indicate the immediate recirculation rate, the results obtained may not correlate with Kt/V. In contrast, the clearance gap (CL-Gap) method provides the total recirculation rate per dialysis session and correlates well with Kt/V. We assessed the correlation between Kt/V and CL-Gap as well as the change in radial artery (RA) blood flow speed in the fistula before percutaneous transluminal angioplasty (PTA) in 45 patients undergoing continuous hemodialysis. The dialysis dose during the determination of CL-Gap was 1.2 to 1.4 Kt/V. Patients with a 10% elevation or more than a 10% relative increase in CL-Gap underwent PTA (n = 45), and the values obtained for Kt/V and CL-Gap before PTA were compared with those obtained immediately afterward. The mean RA blood flow speed improved significantly (from 52.9 to 97.5cm/sec) after PTA, as did Kt/V (1.07 to 1.30) and CL-Gap (14.1% to -0.2%). A significant correlation between these differences was apparent (r = -0.436 and p = 0.003). These findings suggest that calculating CL-Gap may be useful for determining when PTA is required and for assessing the effectiveness of PTA, toward obtaining better dialysis.
- Published
- 2012
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50. Aldosterone suppresses insulin signaling via the downregulation of insulin receptor substrate-1 in vascular smooth muscle cells.
- Author
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Hitomi H, Kiyomoto H, Nishiyama A, Hara T, Moriwaki K, Kaifu K, Ihara G, Fujita Y, Ugawa T, and Kohno M
- Subjects
- Angiotensin II pharmacology, Animals, Cells, Cultured, Insulin Receptor Substrate Proteins, Insulin Resistance physiology, Muscle, Smooth, Vascular cytology, Oncogene Protein v-akt metabolism, Phosphoproteins genetics, Phosphorylation, Proteasome Endopeptidase Complex physiology, Rats, Reactive Oxygen Species metabolism, src-Family Kinases physiology, Aldosterone physiology, Down-Regulation, Insulin physiology, Muscle, Smooth, Vascular metabolism, Phosphoproteins metabolism, Signal Transduction physiology
- Abstract
Clinical reports indicate that patients with primary aldosteronism commonly have impaired glucose tolerance; however, the relationship between aldosterone and insulin signaling pathway has not been clarified. In this study, we examined the effects of aldosterone treatment on insulin receptor substrate-1 expression and insulin signaling pathway including Akt phosphorylation and glucose uptake in rat vascular smooth muscle cells. Insulin receptor substrate-1 protein expression and Akt phosphorylation were determined by Western blot analysis with anti-insulin receptor substrate-1 and phosphorylated-Akt antibodies, respectively. Glucose metabolism was evaluated using (3)H-labeled 2-deoxy-d-glucose uptake. Aldosterone (1-100 nmol/L) dose-dependently decreased insulin receptor substrate-1 protein expression with a peak at 18 hours (n=4). Aldosterone-induced degradation of insulin receptor substrate-1 was markedly attenuated by treatment with the selective mineralocorticoid receptor antagonist eplerenone (10 micromol/L; n=4). Furthermore, degradation was blocked by the Src inhibitor PP1 (20 micromol/L; n=4). Treatment with antioxidants, N-acetylcysteine (10 mmol/L), or ebselen (40 micromol/L) also attenuated aldosterone-induced insulin receptor substrate-1 degradation (n=4). In addition, proteasome inhibitor MG132 (1 micromol/L) prevented insulin receptor substrate-1 degradation (n=4). Aldosterone treatment abolished insulin-induced Akt phosphorylation (100 nmol/L; 5 minutes; n=4). Furthermore, aldosterone pretreatment decreased insulin-stimulated (100 nmol/L; 60 minutes; n=4) glucose uptake by 50%, which was reversed by eplerenone (10 micromol/L; n=4). These data indicate that aldosterone decreases insulin receptor substrate-1 expression via Src and reactive oxygen species stimulation by proteasome-dependent degradation in vascular smooth muscle cells; thus, aldosterone may be involved in the pathogenesis of vascular insulin resistance via oxidative stress.
- Published
- 2007
- Full Text
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